bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
influenza virus	266
respiratory syndrome	232
supplemental material	184
acute respiratory	175
severe acute	155
virus infection	142
syndrome coronavirus	140
small rnas	126
rna viruses	122
infected cells	97
immune response	94
viral rna	92
middle east	91
gene expression	88
small rna	84
east respiratory	82
influenza viruses	75
rna virus	68
amino acid	67
escherichia coli	67
avian influenza	66
vero cells	66
immune responses	65
public health	64
cov ma	63
cord uid	62
previously described	62
mbio doi	62
doc id	62
cov infection	61
virus replication	59
ebola virus	59
viral replication	57
highly pathogenic	54
cell surface	54
cell responses	53
viral infection	52
data set	51
cell culture	50
mediated ifn	49
ebov gp	49
infected mice	49
dsrna viruses	47
stranded rna	46
innate immune	46
parainfluenza virus	46
respiratory disease	45
performed using	44
virus titers	44
cov nsp	44
see table	43
antiviral activity	43
host response	43
fatty acid	42
room temperature	42
viral genome	42
described previously	42
epithelial cells	42
cell lines	41
cd expression	41
virus type	41
flow cytometry	40
differentially expressed	40
protein kinase	40
bone marrow	39
veroe cells	39
amino acids	39
ko mice	39
united states	39
reverse transcription	39
pandemic influenza	38
dmv formation	38
pl flux	38
time points	38
determine whether	38
novel coronavirus	38
thermo fisher	38
receptor binding	37
time point	37
predict pdf	37
mice infected	36
bovine serum	36
spike protein	36
viroporin domain	35
cdna clone	35
infectious diseases	35
urokinase pathway	34
protein expression	33
linked glycans	33
viral proteins	33
roni cells	33
convalescent plasma	33
pl synthesis	33
closely related	33
respiratory syncytial	32
pkr mrna	32
well plates	32
cell activation	32
syncytial virus	32
human coronavirus	32
weight loss	31
human cells	31
immunodeficiency virus	31
virus infections	31
cell types	31
lgi network	31
cells infected	31
differential expression	31
clinical samples	31
lung injury	31
virus transmission	31
following sars	30
potential pandemic	30
rna polymerase	30
risk assessment	30
type i	29
respiratory tract	29
human immunodeficiency	29
buffered saline	29
infectious cdna	28
dendritic cells	28
open reading	28
significantly higher	28
see also	28
convalescent subjects	27
porcine epidemic	27
research enterprise	27
monoclonal antibody	27
ko cells	27
sars coronavirus	27
phylogenetic analysis	27
genome sequence	27
pdf file	27
genomic rna	27
coronavirus infection	27
host range	26
genome sequences	26
mouse model	26
putative small	26
endoplasmic reticulum	26
ma infection	26
dimer interface	25
data suggest	25
emc infection	25
clinical signs	25
capsid protein	25
pandemic potential	25
veroe tmprss	25
pkr protein	25
nasal swabs	25
tif file	25
unexposed subjects	25
following infection	25
class ii	24
like protease	24
total rna	24
epidemic diarrhea	24
rna synthesis	24
cynomolgus macaques	24
rna loci	24
innate immunity	24
vaccinia virus	24
nipah virus	24
tmprss cells	24
human parainfluenza	24
wt vol	23
deep sequencing	23
accession number	23
lung pathology	23
network analysis	23
dependent rna	23
plasma membrane	23
previously reported	23
bl mefs	23
complement system	23
zippered er	22
antibody titers	22
statistically significant	22
live attenuated	22
reverse genetics	22
igg mbcs	22
combo alum	22
fetal bovine	22
glycan array	22
heparan sulfate	22
genome sequencing	22
seasonal influenza	22
also observed	22
pkr degradation	21
cell epitopes	21
tissue culture	21
protease inhibitor	21
fisher scientific	21
vol vol	21
binding site	21
saudi arabia	21
adaptive immune	21
article may	21
expression levels	21
acute lung	21
host responses	21
health care	21
expression patterns	21
pathogenic avian	21
times postinfection	21
days postinfection	20
signaling pathway	20
immunized mice	20
combo smq	20
human oas	20
virus evolution	20
dromedary camels	20
may also	20
fluorescent protein	20
candida albicans	20
nonstructural protein	20
recombinant viruses	20
viral genomes	20
cd upregulation	20
lysis buffer	20
onward transmission	20
plaque assay	20
class i	20
glycan cap	19
recognition receptors	19
treated control	19
results suggest	19
clinical trials	19
mg kg	19
diarrhea virus	19
hepatitis virus	19
analyzed using	19
blot analysis	19
protein synthesis	19
reverse transcriptase	19
binding domain	19
viroporin activity	19
fusion protein	19
mrna levels	19
gp core	19
membrane structures	19
mammalian cells	19
vaccine development	18
peritoneal macrophages	18
wt mice	18
gene product	18
unknown function	18
mhc class	18
cov pathogenesis	18
knockout mice	18
host cell	18
cov spike	18
western blotting	18
codon usage	18
least one	18
murine coronavirus	18
three times	18
well plate	18
streptococcus equi	18
cells treated	18
varroa mites	18
membrane synthesis	18
national institute	18
bat cells	18
human cases	18
pattern recognition	18
control group	18
type mice	18
strand rna	18
low levels	18
immune system	18
serum samples	18
results indicate	18
large number	18
crystal structure	18
viral infections	18
novel human	18
honey bee	17
signaling pathways	17
i interferon	17
airborne transmission	17
mg ml	17
neuraminidase activity	17
genbank accession	17
antibody responses	17
ferret model	17
nsp viroporin	17
time pcr	17
codon selection	17
viral entry	17
human airway	17
inflammatory cells	17
antiviral drugs	17
disease virus	17
reading frame	17
human infection	17
biosafety level	17
puncta formation	17
vaccine candidate	17
animal model	17
late endosomes	17
immune cells	17
plant viruses	16
previous studies	16
cell immunity	16
pandemic preparedness	16
like receptor	16
st isolates	16
respiratory distress	16
distress syndrome	16
culture medium	16
clinical symptoms	16
ev infection	16
neutralizing antibodies	16
elapsed time	16
green fluorescent	16
severe disease	16
virus glycoprotein	16
complement activation	16
cells expressing	16
infected samples	16
select agent	16
transcriptome sequencing	16
determined using	16
primary antibody	16
lung samples	16
quantitative pcr	16
cultured cells	16
high levels	16
glycan determinants	16
peripheral blood	16
nsp nsp	16
protein levels	16
animal models	16
lps synthesis	16
expressing cells	16
lung disease	16
hela cells	16
cell response	16
viral particles	16
infected animals	16
alphavirus supergroup	15
human respiratory	15
mm tris	15
spike glycoprotein	15
binding sites	15
proteolytic processing	15
increased replication	15
respiratory droplets	15
viral titers	15
respiratory viruses	15
egyptian rousette	15
cell line	15
membrane insertion	15
like viruses	15
reading frames	15
posttranslational control	15
lung tissue	15
lower respiratory	15
host cells	15
dominant negative	15
pkr depletion	15
sequencing analysis	15
rdrp tree	15
national institutes	15
pfu cell	15
specific igg	15
via respiratory	15
fusion proteins	15
viral protein	15
march proteins	15
expression changes	15
viral isolation	15
critical role	15
life technologies	15
bl mice	15
recombinant virus	15
kinase inhibitors	15
adenovirus type	15
rna processing	15
infectious virus	15
inflammatory response	15
statistical analysis	15
viral dna	15
host factors	15
vaccine candidates	15
replication fidelity	15
nucleoside analogues	14
north carolina	14
samples collected	14
infected lysates	14
confocal microscopy	14
microarray data	14
optical density	14
viral sequences	14
wt cells	14
viral isolates	14
viral small	14
plsb activity	14
mbcs reactive	14
present study	14
cytopathic effect	14
cell cultures	14
healthy donors	14
nucleocapsid protein	14
membrane protein	14
disease severity	14
day postinfection	14
tracheal wash	14
host damage	14
function experiments	14
lethal dose	14
gp expression	14
igg titers	14
host genes	14
significant differences	14
case fatality	14
previous work	14
complement pathway	14
mouse strains	14
data indicate	14
western blot	14
complement signaling	14
complete genome	14
coronavirus disease	14
linked immunosorbent	14
coronavirus replication	14
histolytica infection	14
expressing mers	14
scientific catalog	13
related viruses	13
tcid ml	13
bd biosciences	13
mice immunized	13
bacterial infections	13
mouse adenovirus	13
treated ferrets	13
accessory genes	13
mycobacterium tuberculosis	13
virus strain	13
world health	13
equi subsp	13
log fc	13
serum albumin	13
cryptococcal meningitis	13
cleavage site	13
proinflammatory cytokines	13
isolates recovered	13
test compounds	13
accession numbers	13
state growth	13
measles virus	13
segmented filamentous	13
important role	13
ge healthcare	13
ml streptomycin	13
sfcs pbmcs	13
medium containing	13
reactive igg	13
antigen presentation	13
common ancestor	13
treated group	13
acid synthesis	13
active site	13
cmt cells	13
lung lesions	13
rna virome	13
transmission studies	13
neutralizing antibody	13
mouse anti	13
also found	13
health organization	13
restriction sites	13
rpmi medium	13
dna replication	13
fusion promotion	13
nucleic acid	13
oas genes	12
gene products	12
vesicular stomatitis	12
transcriptional regulation	12
viral reads	12
positive cells	12
highly conserved	12
severe respiratory	12
human transmission	12
lookup suppl	12
lung tissues	12
infectious agents	12
stomatitis virus	12
ns protein	12
taken together	12
bat coronaviruses	12
mass spectrometry	12
infected ferrets	12
monoclonal antibodies	12
gof experiments	12
cell lysates	12
data sets	12
cell lysis	12
ml penicillin	12
molecular basis	12
hn mutations	12
nucleoside analogue	12
protective immunity	12
neutral red	12
respiratory virus	12
dependent manner	12
generation sequencing	12
infectious center	12
erasmus mc	12
respiratory droplet	12
structural proteins	12
reactive mbcs	12
neutralizing activity	12
proteasomal degradation	12
viroporin mutants	12
cell entry	12
purified using	12
phylogenetic tree	12
suppl doi	12
hek cells	12
clinical sample	12
surface expression	12
virus entry	12
mouse hepatitis	12
circular profiles	12
thermo scientific	12
immune evasion	12
novel potential	12
motif i	12
nonstructural proteins	12
human infections	12
pandemic pathogen	12
protective equipment	12
host gene	12
previously observed	12
even though	12
pandemic pathogens	12
mers coronavirus	12
binding lectin	12
lc ms	12
horseradish peroxidase	12
graphpad prism	12
filamentous bacteria	12
clinical features	12
length gp	12
virus genome	12
noncoding rnas	12
body weight	12
generated using	12
hiv infection	12
staphylococcus aureus	12
distantly related	12
org lookup	12
sequence alignment	12
systems biology	11
oligoadenylate synthetase	11
accelerating factor	11
nh cl	11
like virus	11
rna release	11
time reverse	11
tumor necrosis	11
animal care	11
inherent safety	11
viral envelope	11
length infectious	11
gof studies	11
secondary antibody	11
sv mefs	11
apis mellifera	11
length cdna	11
sequence data	11
mononuclear cells	11
late times	11
average log	11
goat anti	11
infected patients	11
deficient mice	11
first time	11
mature mirnas	11
annotated loci	11
recent study	11
specific cd	11
binding receptors	11
sequence similarity	11
applied biosystems	11
histocompatibility complex	11
gene sets	11
associated molecular	11
nd nd	11
site ii	11
genomic regions	11
mediated endocytosis	11
envelope glycoproteins	11
fecal samples	11
mm nacl	11
disease control	11
blood mononuclear	11
also thank	11
coronavirus associated	11
provide protection	11
gof research	11
spike gene	11
naturally occurring	11
cd blockade	11
host immune	11
inactivated mers	11
northern blot	11
blood samples	11
ng ml	11
viral pathogens	11
lethal challenge	11
different aivs	11
cellular immune	11
candidate loci	11
mers fl	11
unc health	11
airway epithelial	11
st strains	11
virus ns	11
fatality rate	11
years ago	11
african green	11
henipavirus infection	11
gene function	11
brief exposure	11
sybr green	11
viral pathogenesis	11
major histocompatibility	11
colonized mice	11
pl pro	10
reverse transcribed	10
mouth disease	10
restriction site	10
compared using	10
exposed subjects	10
virus vaccine	10
acid sequence	10
monkey kidney	10
noncoding rna	10
whole blood	10
mirna expression	10
reference genome	10
skin fibroblasts	10
research pause	10
cell viability	10
functional analysis	10
hn protein	10
hong kong	10
dengue virus	10
growth factor	10
using primers	10
replication kinetics	10
influenza infection	10
per year	10
furin cleavage	10
protective efficacy	10
major branches	10
rectal swabs	10
mice lacking	10
copy numbers	10
sequence identity	10
gc content	10
membrane permeability	10
kindly provided	10
membrane vesicles	10
wt nsp	10
medium supplemented	10
positive control	10
cytokine production	10
protease inhibitors	10
target cells	10
tlr signaling	10
global rna	10
immune reconstitution	10
tissue damage	10
overall clinical	10
cells using	10
likely due	10
data demonstrate	10
wide range	10
cells exposed	10
upper respiratory	10
phospholipid synthesis	10
trsv isolates	10
expression profiles	10
see materials	10
results demonstrate	10
virus hemagglutinin	10
pbs containing	10
virus shedding	10
gene set	10
rna interference	10
wash fluid	10
influenza pandemic	10
genetic changes	10
community lai	10
replication complex	10
necrosis factor	10
technical assistance	10
influenza vaccine	10
santa cruz	10
cell death	10
statistical significance	10
secondary structure	10
clinical strains	10
significantly increased	10
catalytic domain	10
mutational robustness	10
new york	10
transiently transfected	10
pcr using	10
integral membrane	10
mm edta	10
superscript iii	10
care workers	10
functional receptor	9
hdpp ki	9
situ hybridization	9
like particles	9
final concentration	9
calcium levels	9
inflammatory cytokines	9
molecular mechanisms	9
analysis revealed	9
mdck cells	9
reconstitution inflammatory	9
receptor signaling	9
thermal stability	9
acp concentrations	9
higher levels	9
measured using	9
signaling cascade	9
candida glabrata	9
increased il	9
pcr analysis	9
ion channel	9
also detected	9
colony collapse	9
virus rdrps	9
droplet transmission	9
mice showed	9
culture supernatants	9
ec values	9
strongly supported	9
small interfering	9
mock infected	9
piv expressing	9
resistant bacteria	9
hyaline membranes	9
luciferase assay	9
increased delivery	9
induce dmv	9
cov replication	9
clinical isolate	9
embryonic fibroblasts	9
provide evidence	9
viruses isolated	9
sequence analysis	9
primary human	9
dna viruses	9
based vaccine	9
antibody response	9
right panel	9
specific antibody	9
mirna precursors	9
health risks	9
rna libraries	9
exon activity	9
mm hepes	9
reactive mbc	9
protein sequences	9
will allow	9
virus groups	9
laboratory workers	9
sequencing reads	9
alveolar macrophages	9
connectivity map	9
small nucleolar	9
viral genes	9
equine encephalitis	9
expressed mirnas	9
treated groups	9
viral mrna	9
matched mock	9
coronavirus nsp	9
pandemic risk	9
increased levels	9
quantitative reverse	9
weak colonies	9
analysis using	9
calcium homeostasis	9
internal proteins	9
coronavirus vaccine	9
rna genome	9
cryptococcus neoformans	9
spr analysis	9
data show	9
antiviral response	9
chain reaction	9
epa adhesins	9
modified eagle	9
oas gene	9
transmissible gastroenteritis	9
cell monolayers	9
deformed wing	9
molecular weight	9
washed twice	9
bee colonies	9
green monkey	9
envelope glycoprotein	9
eagle medium	9
kinase pkr	9
dipeptidyl peptidase	9
increased fidelity	9
virus titration	9
ebov entry	9
quantitative real	9
inflammatory syndrome	9
mock infection	9
encephalitis virus	9
healthy controls	9
immunosorbent assay	9
least three	9
cov pseudovirus	9
highly expressed	9
lung lobes	9
also used	9
considered significant	9
transfected cells	9
nl virus	9
cytoplasmic ca	9
use research	9
pcr system	9
sequencing data	9
rabbit anti	9
either niv	9
viral fusion	9
adapted sars	9
allele frequency	9
cell cross	9
venezuelan equine	9
highly connected	9
antiviral drug	9
three independent	9
rna species	9
cov challenge	9
mice exhibited	9
lethal disease	9
inhibitory effect	9
sindbis virus	9
future studies	9
iu ml	9
wing virus	9
ex vivo	9
fold changes	9
membrane pairing	8
rna polymerases	8
fungal clearance	8
causative agent	8
basal oas	8
human march	8
cov infectious	8
naked rna	8
human coronaviruses	8
sample preparation	8
fatality burden	8
influenza vaccines	8
statistical analyses	8
significantly upregulated	8
ki mice	8
per well	8
bronchoalveolar lavage	8
using anti	8
strongly suggest	8
single lab	8
among rna	8
genetics system	8
associated cryptococcosis	8
significantly decreased	8
bee pollen	8
synthesis pathways	8
virus taxonomy	8
personal protective	8
coronavirus infections	8
cell receptor	8
ecm remodeling	8
serine protease	8
cornell ahdc	8
previous study	8
low ph	8
multiple nucleoside	8
calculated using	8
smegmatis mc	8
provided protection	8
virus particles	8
pfu ml	8
test whether	8
mir hg	8
envelope protein	8
formic acid	8
type response	8
horse population	8
tree topology	8
mrna expression	8
gut microbiota	8
expression data	8
pcr amplification	8
igg levels	8
cov sequences	8
epithelial cell	8
polymerase chain	8
risk factors	8
publicly available	8
receptor cleavage	8
long transcripts	8
gp proteins	8
recombinant parainfluenza	8
dna polymerase	8
two viruses	8
virus growth	8
reaction products	8
rna copy	8
small number	8
may function	8
induced ifn	8
binding intensity	8
combo formulated	8
hn dimer	8
virus clearance	8
sfb colonization	8
factor alpha	8
polyprotein processing	8
viral titer	8
upregulate cd	8
nsp junction	8
independent manner	8
valley fever	8
murine hepatitis	8
consensus sequence	8
two different	8
healthy horses	8
evolutionary relationships	8
risks revisited	8
dmem supplemented	8
mc facility	8
infection model	8
bee viruses	8
available online	8
functional genomics	8
unclear whether	8
recent studies	8
human error	8
evolutionary history	8
heterosubtypic protection	8
array screening	8
pkr ubiquitination	8
membrane fusion	8
replicase proteins	8
zooepidemicus isolates	8
expression vector	8
cdna clones	8
genetic diversity	8
function research	8
endothelial cells	8
secondary structures	8
lysine residues	8
elispot assay	8
rna replication	8
adaptor protein	8
dmem containing	8
secreting cells	8
early viral	8
negative control	8
cd ko	8
oas proteins	8
mouse pkr	8
apical surface	8
inhibitory effects	8
lectin binding	8
sars virus	8
genomic analysis	8
using superscript	8
reported previously	8
virus titer	8
plasmid pbac	8
related signaling	8
much less	8
ringspot virus	8
rna isolation	8
human influenza	8
comparative analysis	8
st strain	8
presentation pathway	8
red blood	8
bat coronavirus	8
human betacoronavirus	8
rift valley	8
viral diversity	8
genes encoding	8
control mice	8
respiratory illness	8
coronavirus nonstructural	8
lung lobe	8
number gse	8
like receptors	8
binding specificity	8
mediated damage	8
recombinant mers	8
enzyme concentrations	8
genomic sequences	8
alexa fluor	8
outer membrane	8
fold change	8
phylogenetic analyses	8
nucleic acids	8
loci overlapped	8
deletion mutants	8
transcriptional control	8
viral rnas	8
least two	8
translation inhibition	8
acquired infection	8
functional annotation	8
beta interferon	8
postdoctoral fellows	8
cd surface	8
future plans	8
transmission via	8
clinical disease	8
lab escape	8
infected ko	8
molecular patterns	7
receptor specificity	7
attenuated viruses	7
ci wt	7
boas gene	7
different viruses	7
salmonella typhi	7
time rt	7
treated cells	7
total number	7
vaccine virus	7
nucleotide diversity	7
upstream regulators	7
pathogenic influenza	7
total pkr	7
opsonizing antibodies	7
network strategy	7
induced acute	7
pfu piv	7
entry requires	7
vaccine viruses	7
ev entry	7
lung sections	7
next day	7
type mefs	7
significant increase	7
activated protein	7
via posttranslational	7
cells per	7
convalescent individuals	7
rna locus	7
infected cell	7
mm sodium	7
type nsp	7
invasive gas	7
detectable virus	7
identified using	7
dna fragments	7
nsp expression	7
regulatory factor	7
virus genomes	7
international committee	7
docx file	7
stimulating factor	7
negative controls	7
simplex virus	7
nucleotide sequence	7
highly susceptible	7
select agents	7
cytosolic pamp	7
live virus	7
marrow cells	7
binding properties	7
mucosal immunity	7
influenza risk	7
selective pressure	7
igg antibody	7
potential targets	7
previous reports	7
sinv replication	7
vero cell	7
gof ppp	7
phosphate buffer	7
cell reactivities	7
life sciences	7
herpes simplex	7
group showed	7
bacterial coinfections	7
catb independence	7
vp antibody	7
mutation rate	7
clinical scores	7
value represents	7
time course	7
lps flux	7
structural basis	7
genome browser	7
hplc ms	7
virus isolation	7
entamoeba histolytica	7
new human	7
increased resistance	7
common ancestry	7
inflammatory responses	7
genomic sequence	7
rabbit polyclonal	7
long ncrnas	7
glycans present	7
nucleotide sequences	7
bacterial infection	7
pedv pc	7
purinergic signaling	7
main protease	7
similar results	7
positive signal	7
red arrows	7
viral genomic	7
endosomal acidification	7
recently reported	7
per group	7
pcr assay	7
origin influenza	7
mrna bound	7
previously shown	7
amplicon sequencing	7
transcriptional changes	7
sinv infection	7
ifn induction	7
step rt	7
cubic membranes	7
serial dilutions	7
complement deposition	7
interferon production	7
biomedical research	7
nucleolar rnas	7
standard deviation	7
rna silencing	7
coronavirus rna	7
mice compared	7
crystal violet	7
bhk cells	7
healthy donor	7
viral glycoproteins	7
induce ifn	7
interferon regulatory	7
virus production	7
replicate samples	7
primer sequences	7
protein may	7
expression values	7
human lung	7
use committee	7
sirnas targeting	7
infection models	7
myotis lucifugus	7
sublethal dose	7
like coronavirus	7
immunoblot analysis	7
based vaccines	7
multiple cell	7
inhibitor cocktail	7
patient plasma	7
viruses evolved	7
reagent program	7
human sars	7
respiratory coronavirus	7
expression vectors	7
antiviral immunity	7
results suggested	7
host defense	7
new coronavirus	7
rotavirus nsp	7
infectious clone	7
icelandic isolates	7
acid residues	7
like domain	7
nasal discharge	7
confidence interval	7
tobacco ringspot	7
high concentrations	7
ht sequencing	7
rna transcriptome	7
fever virus	7
cytotoxic effects	7
specific antibodies	7
days later	7
pseudotyped viral	7
natural host	7
novel small	7
cell subsets	7
heavy chain	7
immune cell	7
jackson laboratories	7
lysosomal degradation	7
streptococcus pyogenes	7
based surveillance	7
enhanced green	7
nasal washes	7
bronx zoo	7
nsp mda	7
sample collection	7
well understood	7
agent theft	7
directed mutagenesis	7
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attachment receptor	7
analysis showed	7
opsonophagocytic killing	7
minimally pathogenic	7
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hcv patient	7
cell type	7
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medical center	7
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dependent protein	7
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driving force	7
smq adjuvant	7
hiv activity	7
per person	7
significantly lower	7
bio basic	7
mrna level	7
proteins encoded	7
entry mediated	7
rna replicons	7
bat roni	7
upregulated cd	7
cytoplasmic calcium	7
genetic analysis	7
pore size	7
protein degradation	7
growth kinetics	7
vascular permeability	7
receptor avidity	7
left panel	7
envelope proteins	7
mers ma	7
oas protein	7
expressed genes	7
eptesicus fuscus	7
lysis assay	7
purinergic receptor	7
term passage	7
acid identity	7
two independent	7
human glycoproteins	7
rna expression	7
time quantitative	7
stimulated genes	7
viral load	7
sequence homology	6
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liquid chromatography	6
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hn mutation	6
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human services	6
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tlr agonist	6
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cells ml	6
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may play	6
set enrichment	6
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icosahedral capsids	6
animal species	6
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sa nsp	6
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cd mimic	6
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rneasy minikit	6
rectal swab	6
rna helicase	6
dna fragment	6
novel avian	6
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viral gene	6
human mers	6
naive mice	6
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short reads	6
type fimbriae	6
activated macrophages	6
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mbc formation	6
hcq sulfate	6
washed times	6
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pcr assays	6
human pathogens	6
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ring domain	6
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choriomeningitis virus	6
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aids research	6
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nih grant	6
rrna degradation	6
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recent years	6
funding pause	6
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stranded dna	6
ifn treatment	6
rotavirus infection	6
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hendra virus	6
serially diluted	6
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emc induced	6
patience genome	6
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culture plates	6
boas mrna	6
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protease sensitivity	6
dual use	6
human dpp	6
will help	6
protein nsp	6
electron microscopy	6
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blood cells	6
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picornavirus supergroup	6
lymphocytic choriomeningitis	6
glutamic acid	6
cell cycle	6
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glycan interaction	6
point mutation	6
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factors associated	6
mice deficient	6
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dsrna virus	6
aged mice	6
cells showed	6
streptococcus pneumoniae	6
within branch	6
later times	6
tested using	6
among different	6
virus rdrp	6
fresh medium	6
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salmonella enterica	6
roll capsid	6
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marburg virus	6
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species transmission	6
mbc populations	6
human pbmcs	6
biased cross	6
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also table	6
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animal reservoir	6
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acp species	6
similar levels	6
molecular biology	6
containing fbs	6
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pathogenic viruses	6
type virus	6
two families	6
ab levels	6
reverse primer	6
hydroxychloroquine sulfate	6
flow cell	6
human virus	6
fuscus skin	6
coli lysis	6
linked glycan	6
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forward primer	6
constructed using	6
igg antibodies	6
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ucsc genome	6
microrna host	6
collaborative cross	6
tuberculosis infection	6
cm flask	6
veterinary institute	6
interfering rna	6
institutional review	6
cleaving nsp	6
different cell	6
culture isolates	6
lion keepers	6
virus vaccines	6
higher affinity	6
adaptor proteins	6
percent gc	6
type iii	6
data indicated	6
via transcriptional	6
single jelly	6
human health	6
antiviral effect	6
binding proteins	6
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virus expressing	6
monitoring select	6
rotavirus nonstructural	6
secondary bacterial	6
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regulatory protein	6
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sequences obtained	6
prism software	6
human epithelial	6
mouse reference	6
complex class	6
minor allele	6
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delta inulin	6
virus isolates	6
actin filaments	6
sample buffer	6
endosomal maturation	6
lethal infection	6
vortex mixing	6
nonhuman primates	6
march blocks	6
infection date	6
protein structure	6
might also	6
coronavirus emc	6
approved drugs	6
per sample	6
using veroe	6
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specific mutations	6
molecularly based	6
paralysis virus	6
attenuated vaccines	6
mycobacteriophage patience	6
emerging human	6
serum igg	6
genetic variation	6
assay using	6
two compounds	6
antiviral candidates	6
lethal mutagenesis	6
two proteins	6
type infection	6
rousettus aegyptiacus	6
coding genes	6
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cell reactivity	6
related genes	6
kidney cells	6
traf expression	6
candidate vaccine	6
pathogen recognition	6
review board	6
monolayer culture	6
nonessential amino	6
throughout iceland	6
rna genomes	6
high sequence	6
diffuse alveolar	6
additional genes	6
airway epithelium	6
mouse igg	6
kda gp	6
graduate students	6
host transcription	6
uniquely mapped	6
data presented	6
conserved among	6
rna cloning	6
may help	6
genomic characterization	6
respiratory tracts	6
dependent entry	6
deletion mutant	6
gel electrophoresis	6
ammonium chloride	6
splice sites	6
order bunyavirales	6
two time	6
sn titers	6
significantly different	6
wild type	6
flavivirus supergroup	6
polyacrylamide gel	6
ppgpp concentrations	6
entry receptors	6
coding sequences	6
uninfected cells	6
glycans attached	6
glycan sites	6
honeybee colonies	6
serovar typhi	6
fusion complex	6
viruses infecting	6
initiation factor	6
central nervous	6
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genes associated	6
ec value	6
proteolytic cleavage	6
relationships among	6
entry depends	6
human emergence	6
infected pigs	6
growth medium	5
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human cell	5
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disease pathogenesis	5
research intended	5
nonhuman primate	5
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als proteins	5
infected wt	5
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cynomolgus macaque	5
genome annotation	5
dna libraries	5
complex traits	5
induced lung	5
artificial chromosome	5
upstream regulator	5
pmol od	5
synthesis pathway	5
gp glycosylation	5
cause disease	5
untreated cells	5
mirna small	5
viral populations	5
bat oas	5
control sirna	5
clathrin heavy	5
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oas fusion	5
immune signaling	5
guinea pigs	5
ns mutations	5
cell epitope	5
myeloid cells	5
targeting rab	5
intranasal route	5
general population	5
cdna libraries	5
baltimore classes	5
transcription factor	5
mumps virus	5
reactive cd	5
icelandic horses	5
identified several	5
newly generated	5
different groups	5
red infectious	5
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dendritic cell	5
murine model	5
virus rna	5
exact test	5
lpxc concentrations	5
annotated genes	5
sars pandemic	5
assay performed	5
surface hs	5
modified small	5
throughput sequencing	5
least identical	5
well tolerated	5
human receptors	5
cytokine secretion	5
nsp protein	5
care facilities	5
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cell fusion	5
honeybee viruses	5
structural modeling	5
min hold	5
associated mutations	5
pedv strain	5
virus pathogenesis	5
also known	5
abundant small	5
stem cells	5
glycoprotein gp	5
signal sequence	5
immunofluorescence microscopy	5
subcellular localization	5
sucrose gradients	5
order nidovirales	5
standard deviations	5
i signaling	5
induced disease	5
results indicated	5
lung hemorrhage	5
intestinal microbiota	5
uncleaved nsp	5
two groups	5
unc irb	5
modified vaccinia	5
several studies	5
correlation coefficient	5
pathogen interactions	5
also likely	5
newcastle disease	5
reportedly active	5
macaque model	5
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mapped reads	5
virus disease	5
er oas	5
transcript expression	5
institutional animal	5
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branch consists	5
protein fraction	5
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associated coronavirus	5
bars represent	5
gp shedding	5
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converting enzyme	5
also included	5
viral transport	5
mers virus	5
march affects	5
protein might	5
reference reagent	5
bacterial artificial	5
human enterovirus	5
remains unknown	5
eukaryotic rna	5
calf serum	5
interaction networks	5
different species	5
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lymph nodes	5
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mouse proteins	5
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bat species	5
dna virus	5
lung cells	5
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created using	5
total rnas	5
flowjo software	5
superfamily helicase	5
antiviral treatment	5
ron fouchier	5
emc strain	5
pkr activation	5
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strand synthesis	5
killing assay	5
peroxisome proliferator	5
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vaccine strain	5
fold higher	5
buffered formalin	5
infected subjects	5
multiple sequence	5
coding regions	5
purifying respirators	5
changes inventory	5
relatively low	5
binary gradient	5
protein abundance	5
plant virus	5
circular double	5
polyclonal anti	5
bsl conditions	5
array data	5
human adenovirus	5
cryptococcal disease	5
gastroenteritis virus	5
pathological host	5
gas vaccine	5
data using	5
diverse viruses	5
investigate whether	5
relatively high	5
start positions	5
dq bsa	5
synonymous codon	5
cells compared	5
trained innate	5
pcr products	5
fidelity variants	5
acid changes	5
ma pathogenesis	5
ebov igg	5
elispot assays	5
previously published	5
symptom onset	5
immortalized cells	5
min using	5
potent activity	5
significantly reduced	5
sister group	5
sequences available	5
national center	5
identical experiments	5
deoxy sequencing	5
alveolar fibrin	5
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cov genome	5
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hcv patients	5
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cycle threshold	5
arteritis virus	5
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plaque assays	5
confocal microscope	5
zoonotic influenza	5
horseshoe bats	5
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flow cytometer	5
cell suspension	5
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ml min	5
changes induced	5
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fruit bats	5
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nasal turbinate	5
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among humans	5
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bat sars	5
worker bees	5
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day period	5
mmr vaccine	5
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simian virus	5
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human monoclonal	5
hn mutants	5
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inflammatory cell	5
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nasal swab	5
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cells well	5
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nih national	5
culture conditions	5
highly divergent	5
sense rna	5
np pool	5
renal failure	5
also provide	5
identify potential	5
fold increase	5
create novel	5
lgi networks	5
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recombinant pedv	5
macaques inoculated	5
coli fimh	5
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sequence information	5
dnase i	5
center assay	5
synthetic biology	5
bal fluid	5
dimethyl sulfoxide	5
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new virus	5
viral population	5
like bodies	5
binding protein	5
polar interactions	5
gamma interferon	5
related virus	5
significantly less	5
equine arteritis	5
signaling molecules	5
high level	5
complex formation	5
cho cells	5
opposing monomer	5
subgenomic rna	5
internal standards	5
serpine expression	5
infection using	5
reference sequence	5
lung following	5
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complete medium	5
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chain acp	5
cell supernatants	5
first days	5
expression analysis	5
increased survival	5
host receptor	5
th th	5
cell recognition	5
genome segments	5
leukemia virus	5
plasmid dnas	5
nonfat milk	5
nasal turbinates	5
analogue resistance	5
asterisks indicate	5
maximum likelihood	5
innate response	5
mouse monoclonal	5
scientific community	5
agilent bioanalyzer	5
cells produced	5
capsid proteins	5
respiratory samples	5
membrane modifications	5
culture infective	5
extracellular atp	5
humanized plasminogen	5
varroa jacobsoni	5
emerging viruses	5
cells stably	5
state university	5
bacterial strains	5
quantitative rt	5
isolated pbmcs	5
group ii	5
cs values	5
single virus	5
cancer cells	5
previously identified	5
biological processes	5
michael imperiale	5
essential medium	5
purification kit	5
aligned using	5
first step	5
hyaline membrane	5
right lung	5
od value	5
completely blocks	5
lung immunopathology	5
containing mm	5
prepared using	5
amplified using	5
associated protein	5
enzymatic activity	5
derived macrophages	5
coa concentrations	5
fetal calf	5
findings suggest	5
eight hours	5
showed significantly	5
acp levels	5
adaptive mutations	5
mm ammonium	5
fimh adhesin	5
glycosylation site	5
highly virulent	5
using standard	5
virus attachment	5
mechanisms regulating	5
current study	5
mirnas showed	5
global health	5
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igg subclasses	5
common feature	5
diagnostic tests	5
antiviral role	5
pseudotyped virus	5
icelandic veterinary	5
mouse lung	5
vitro stimulation	5
disease among	5
cell memory	5
transcription factors	5
cohort study	5
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cocktail kit	5
one health	5
renilla luciferase	5
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activated receptor	5
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response framework	4
linear model	4
erasmus medical	4
scientific value	4
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preparation kit	4
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also data	4
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cell layers	4
stage lung	4
ebov vp	4
san diego	4
lethal infections	4
transmembrane domains	4
phosphate broth	4
laboratories involved	4
recombinant mouse	4
drug resistance	4
annotations among	4
activated cell	4
membrane formation	4
human peripheral	4
pedv avct	4
library preparation	4
almost entirely	4
blood cell	4
discovered coronavirus	4
infecting aivs	4
many rna	4
gp envelope	4
gross lesions	4
standard protocol	4
without affecting	4
early endosomes	4
linked glycosylation	4
causes pkr	4
ill patients	4
antiviral effects	4
several clinical	4
without ca	4
infectious clones	4
small nuclear	4
i fusion	4
transmission experiments	4
known viral	4
also shown	4
natural sars	4
whitney test	4
degrade pkr	4
respiratory tissues	4
findings indicate	4
ace receptor	4
two washes	4
genes involved	4
molecularbased surveillance	4
host tissues	4
safe vaccine	4
potential exposure	4
associated ring	4
observed increased	4
ferret gain	4
mhv nsp	4
protects mice	4
experiments involving	4
ko roni	4
type mda	4
ms system	4
natural infection	4
immunity may	4
decreased expression	4
va rnas	4
data suggested	4
function debate	4
bacterial cell	4
associated herpesvirus	4
positively stained	4
one host	4
type strain	4
intestinal colonization	4
major tail	4
ferret passage	4
scale changes	4
enhanced chemiluminescence	4
specific infectivity	4
possible role	4
sialic acid	4
molecular evolutionary	4
genome organization	4
enzyme activity	4
module eigengene	4
cause damage	4
experimentally observed	4
mouse oas	4
three major	4
largest rna	4
free water	4
three oas	4
genbank id	4
ferret adapted	4
villous enterocytes	4
gc contents	4
efficient transmission	4
antibody specific	4
observed following	4
key role	4
protein secretion	4
evolutionary genetics	4
animal experiments	4
sinv genomic	4
mediated disease	4
pathway may	4
viruses may	4
antiserum sensitivity	4
lining epithelium	4
significant upregulation	4
west nile	4
cells transfected	4
mouse cells	4
intestinal epithelial	4
study represents	4
data availability	4
mutations found	4
cerebrospinal fluid	4
single mutations	4
nonstructural glycoprotein	4
also increased	4
mycobacteriophage relatives	4
complement protein	4
cause severe	4
translation initiation	4
nrc symposium	4
periodate oxidation	4
chapel hill	4
close mycobacteriophage	4
reaction mixtures	4
uropathogenic escherichia	4
enhanced disease	4
synthesis via	4
receptor recognition	4
molecular masses	4
ngs data	4
plasma therapy	4
independent tests	4
cells transiently	4
reads directly	4
ev uncoating	4
significant difference	4
coronavirus spike	4
mass spectrometer	4
conjugated secondary	4
fatal human	4
newly identified	4
covalent bond	4
coronaviruses shows	4
dotted line	4
fibrin deposition	4
endosomal receptor	4
stranded rnadependent	4
human metapneumovirus	4
biological properties	4
interferon induction	4
lysine cluster	4
data represent	4
much lower	4
cov outbreak	4
gp interactions	4
severely ill	4
may represent	4
igg response	4
acid pathway	4
endosomal cathepsins	4
rabies virus	4
infected mouse	4
step real	4
type ii	4
protein involved	4
highly diverse	4
stable cells	4
intracellular rna	4
chemokine levels	4
charles river	4
novel virus	4
immune suppression	4
studies using	4
evolutionary model	4
previous microarray	4
transcriptase pcr	4
increasing amounts	4
molecular characterization	4
strong immune	4
indirect contact	4
risk analysis	4
marrow dendritic	4
upregulated genes	4
wt sv	4
across different	4
across iceland	4
polymerase activity	4
unintended consequences	4
leukemia cells	4
fecal specimens	4
qpcr assay	4
pfu per	4
amebic infection	4
emerging infectious	4
vaccine design	4
derived dendritic	4
adapted mers	4
nile virus	4
categorical imperative	4
draft genome	4
gp gp	4
virus capsid	4
sodium chlorate	4
virus propagation	4
cluster i	4
potential host	4
negative impact	4
parental virus	4
expiratory flow	4
genomic distribution	4
protein level	4
class pathogen	4
protein alpha	4
using raxml	4
several viruses	4
protein binds	4
mouse oasl	4
previously unannotated	4
fg program	4
genes include	4
strongly downregulated	4
serum antibodies	4
pkr steady	4
log tcid	4
mutations associated	4
data strongly	4
cold pbs	4
peak viral	4
enveloped viruses	4
crispr cas	4
viral spike	4
antiviral efficacies	4
cell growth	4
infectious respiratory	4
using flowjo	4
swine industry	4
hi dcs	4
adult bees	4
coronavirus causes	4
also possible	4
multiple comparisons	4
pandemic threats	4
data support	4
flow cytometric	4
infected lung	4
ngs within	4
tissue sections	4
march also	4
pulmonary disease	4
invasive lethal	4
two additional	4
mammalian host	4
close contact	4
provide insight	4
vaccine expressing	4
horizontal virus	4
rapid response	4
polyclonal antibody	4
cov infections	4
altered glycosylation	4
coronavirus papain	4
inactivating substitutions	4
combination therapy	4
antigenic variation	4
virus antigen	4
unclassified viruses	4
positive selection	4
mice following	4
cells expressed	4
horses residing	4
ammonium acetate	4
global spread	4
detected via	4
multiple groups	4
zooepidemicus strain	4
experimentally confirmed	4
intracellular calcium	4
quality control	4
genome using	4
rna world	4
research involving	4
growth rate	4
specific primers	4
passage experiments	4
hcv infection	4
region corresponding	4
using ingenuity	4
native virions	4
small subset	4
targeted proteomics	4
igg assay	4
now show	4
dodecyl sulfate	4
checkpoint response	4
first confirmed	4
weeks postimmunization	4
using rna	4
arturo title	4
antibody titer	4
living cells	4
either directly	4
conserved epitopes	4
long noncoding	4
different branches	4
infect humans	4
cultured alone	4
bmdcs derived	4
potential antiviral	4
mm iptg	4
cells markedly	4
human populations	4
heterosubtypic protections	4
young children	4
pathogenic sars	4
bronchial submucosal	4
host transcriptome	4
evolutionary scenario	4
ross river	4
rinderpest virus	4
activated cd	4
recent advances	4
acyl carrier	4
body plethysmography	4
accessory proteins	4
asymptomatic transmission	4
risk mitigation	4
small hydrophobic	4
virus strains	4
virus world	4
useful tool	4
lavage fluid	4
million people	4
humanely euthanized	4
host mhc	4
various concentrations	4
may therefore	4
pearson correlation	4
mutations within	4
allowing us	4
molecule inhibitors	4
therapeutic target	4
coronavirus hku	4
patience gp	4
specific gene	4
cytokine responses	4
convalescent donors	4
influenza transmission	4
flow rate	4
mdbk cells	4
lucifugus skin	4
novel host	4
views expressed	4
tail subunit	4
interface footprint	4
potential use	4
two horses	4
results show	4
coronavirus oc	4
hcov oc	4
coli cells	4
experimental adaptation	4
like gene	4
unknown viral	4
plsb inhibition	4
weighted gene	4
structural analysis	4
brief culture	4
culture supernatant	4
tryptose phosphate	4
many years	4
dmv interior	4
analysis shows	4
diverse virus	4
lesions compared	4
virus interaction	4
mrna splicing	4
transcribed using	4
cov disease	4
bd pharmingen	4
tested positive	4
bipartite network	4
differential scanning	4
sequenced using	4
cell recruitment	4
drug candidates	4
synthesis regulation	4
syndrome virus	4
rna accumulation	4
nucleotide level	4
rna transport	4
virus must	4
exudative phase	4
including microrna	4
animal health	4
mers spike	4
early studies	4
study showed	4
knowledge base	4
iron acquisition	4
virus stocks	4
virus detection	4
shows potential	4
virus isolate	4
plasmid containing	4
early time	4
samples using	4
gas infection	4
laboratory accident	4
drugs will	4
stably expressing	4
previously found	4
streptococcal vaccine	4
tris ph	4
ppgpp synthesis	4
mean od	4
competitive fitness	4
using gene	4
powered air	4
flow cells	4
rna samples	4
host transcriptional	4
mm formic	4
lung fibrosis	4
lung damage	4
fn interaction	4
three different	4
influenza research	4
initiate infection	4
mammalian viruses	4