trigram

This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

trigram	frequency
severe acute respiratory	155
the supplemental material	155
acute respiratory syndrome	149
in the supplemental	144
the presence of	142
respiratory syndrome coronavirus	140
s in the	108
as well as	95
h n influenza	87
middle east respiratory	81
east respiratory syndrome	80
influenza a virus	77
nsp and nsp	77
the number of	71
the absence of	71
in the lungs	66
analysis of the	59
the lungs of	56
in the absence	55
h n virus	53
in the presence	51
the expression of	50
in this study	50
the role of	50
as previously described	48
according to the	48
table s in	47
influenza virus infection	47
of h n	46
of rna viruses	46
in addition to	45
the use of	45
the development of	44
compared to the	44
of severe acute	44
in order to	43
see table s	43
the cells were	42
of the viral	41
due to the	41
of the virus	41
at room temperature	40
for min at	40
we found that	40
based on the	39
and h n	39
data not shown	38
it has been	37
n influenza virus	37
a and b	37
in the lung	37
was added to	36
members of the	36
was used to	36
to determine whether	36
has been shown	35
the formation of	35
the united states	35
the ability of	34
the case of	34
mice infected with	34
the h n	34
been shown to	33
to determine the	33
of rnase l	33
a number of	33
of influenza a	33
the probability of	33
is required for	33
as described previously	32
one of the	32
in the case	32
in the united	32
respiratory syncytial virus	32
for h at	31
h n and	31
the activation of	31
in response to	30
an moi of	30
consistent with the	30
cells infected with	29
human immunodeficiency virus	29
of a novel	29
the urokinase pathway	29
were infected with	28
at an moi	28
were used to	28
the lack of	27
the context of	27
c bl j	27
activation of the	27
of the host	27
the university of	27
a total of	27
shown in fig	26
the s protein	26
similar to those	26
associated with the	26
those of the	26
cov ma infection	26
present in the	26
a h n	26
were obtained from	26
t cell activation	26
the evolution of	26
in escherichia coli	26
supplemental material for	25
in the context	25
cells were infected	25
genes at hpi	25
the importance of	25
the viral genome	25
the host response	25
the viroporin domain	25
region of the	25
of small rnas	25
data suggest that	25
observed in the	25
in the same	25
suggesting that the	24
porcine epidemic diarrhea	24
in contrast to	24
veroe tmprss cells	24
virus titers in	24
as described above	24
such as the	24
small rna loci	24
c bl mefs	23
added to the	23
the p x	23
t cells were	23
the cell surface	23
of viral rna	23
the majority of	23
at the time	23
p x r	23
of influenza virus	23
the level of	23
was performed using	23
avian influenza a	23
all of the	23
the levels of	23
innate immune response	23
to that of	23
was observed in	23
the immune response	23
has not been	22
fetal bovine serum	22
be found at	22
the binding of	22
human parainfluenza virus	22
may be found	22
of middle east	22
immune response to	22
hepatitis c virus	22
cov nsp and	22
that of the	22
n influenza a	22
indicating that the	22
activation of rnase	22
a novel coronavirus	22
found to be	22
the emergence of	22
to those of	22
found in the	21
n and h	21
acute lung injury	21
this article may	21
the percentage of	21
of rna virus	21
it is possible	21
expression of the	21
thermo fisher scientific	21
p x receptor	21
article may be	21
a set of	21
material for this	21
for this article	21
changes in the	21
host response to	21
h n viruses	21
the ability to	21
is consistent with	21
were stained with	21
highly pathogenic avian	21
similar to that	20
the complement system	20
the end of	20
cells were washed	20
the time of	20
some of the	20
b and c	20
the effects of	20
of nsp and	20
were determined by	19
the fact that	19
a role in	19
were observed in	19
e and f	19
in cell culture	19
the possibility that	19
for the presence	19
the ph n	19
immunodeficiency virus type	19
results suggest that	19
epidemic diarrhea virus	19
because of the	19
each of the	19
the middle east	19
were cultured in	19
hek t cells	19
see also fig	19
putative small rna	19
in patients with	19
was used as	19
mutations in the	19
is possible that	19
was determined by	19
cells were cultured	18
virus in the	18
is known to	18
cells were incubated	18
at least one	18
the loss of	18
part of the	18
cells in the	18
our understanding of	18
in unexposed subjects	18
known to be	18
the severe acute	18
in which the	18
characterization of a	18
results indicate that	18
c and d	18
suggest that the	18
influenza virus transmission	18
in vero cells	18
pathogenic avian influenza	18
cells treated with	18
was supported by	18
related to the	18
with pandemic potential	18
structure of the	18
a in the	18
of convalescent plasma	18
used as a	17
pattern recognition receptors	17
of the viroporin	17
by plaque assay	17
the production of	17
the onset of	17
in infected cells	17
the rate of	17
large number of	17
and stored at	17
no effect on	17
the gp core	17
of unknown function	17
there is no	17
infectious cdna clone	17
understanding of the	17
responsible for the	17
but not in	17
to identify the	17
from the same	17
of ph n	17
it is important	17
the accumulation of	17
upregulation of cd	17
de genes at	17
the identification of	17
s a in	17
the results of	17
national institute of	17
response to infection	16
in vitro and	16
to investigate the	16
cells were transfected	16
we also observed	16
the innate immune	16
most of the	16
exposed to sars	16
involved in the	16
be used to	16
respiratory distress syndrome	16
s and s	16
dependent rna polymerase	16
of the cells	16
of trsv in	16
resulted in a	16
relative to the	16
balb c mice	16
of the mers	16
of the same	16
were used for	16
closely related to	16
to determine if	16
materials and methods	16
suggests that the	16
in saudi arabia	16
in terms of	16
virus infection in	16
the generation of	16
cell responses to	16
is important to	16
the pathogenesis of	16
for h n	16
multiplicity of infection	16
the lgi network	16
and that the	16
type i interferon	16
the members of	15
was detected in	15
in the future	15
are consistent with	15
mice than in	15
national institutes of	15
open reading frame	15
as shown in	15
of the two	15
avian influenza viruses	15
the effect of	15
were purchased from	15
used in the	15
and infectious diseases	15
green fluorescent protein	15
of the nsp	15
low levels of	15
were exposed to	15
predicted to be	15
the amount of	15
avian influenza virus	15
on the basis	15
response to sars	15
allergy and infectious	15
presence of the	15
the exception of	15
treated control group	15
insight into the	15
c bl mice	15
the glycan cap	15
to virus infection	15
with the exception	15
the basis of	15
were subjected to	15
the s subunit	15
was performed on	15
approved by the	15
of the complement	15
infected with sinv	15
influenza a viruses	15
on influenza virus	15
influenza virus a	15
is associated with	15
in the present	14
at the end	14
were detected in	14
were recovered from	14
obtained from the	14
were able to	14
influenza a h	14
emc and sars	14
of the sars	14
the possibility of	14
rna virus evolution	14
detected in the	14
were provided by	14
airborne transmission of	14
due to a	14
of escherichia coli	14
in table s	14
that it is	14
of allergy and	14
it is not	14
corresponding to the	14
of the urokinase	14
of the h	14
the present study	14
we hypothesized that	14
the public health	14
the research enterprise	14
pandemic h n	14
during virus infection	14
t cell responses	14
of at least	14
characterization of the	14
identified in the	14
of the lung	14
of the human	14
the fatty acid	14
were incubated with	14
at the same	14
in human cells	14
influenza virus h	14
of highly pathogenic	14
institutes of health	14
with influenza virus	14
were found to	14
many of the	14
the plasma membrane	14
of the p	14
is able to	14
infected with the	14
via respiratory droplets	14
not required for	14
virus in ferrets	13
supplemented with fetal	13
the predict pdf	13
to h n	13
of the spike	13
cytokines and chemokines	13
is dependent on	13
against h n	13
droplets or aerosols	13
in dromedary camels	13
at h postinfection	13
scientific catalog no	13
bovine serum albumin	13
respiratory droplets or	13
for min and	13
p values of	13
acute respiratory distress	13
of the protein	13
have been reported	13
x r ko	13
the specificity of	13
are shown in	13
of the genome	13
in c bl	13
are known to	13
the spike protein	13
a combination of	13
exposure to culture	13
were collected at	13
were performed using	13
and stained with	13
using the same	13
been deposited in	13
institute of allergy	13
expression in the	13
a multiplicity of	13
rna was extracted	13
mice immunized with	13
fatty acid and	13
pathogens with pandemic	13
there was no	13
role in the	13
parainfluenza virus type	13
were treated with	13
data indicate that	13
world health organization	13
cells were lysed	13
of t cell	13
well as the	13
a variety of	13
linked glycans on	13
an important role	13
changes in expression	13
open reading frames	13
cultured in the	13
high levels of	13
subunit of the	13
the induction of	13
these data suggest	13
fatty acid synthesis	13
ebola virus glycoprotein	13
streptococcus equi subsp	13
binding to the	13
were generated by	13
were transfected with	13
has been reported	13
gp and gp	13
mouse adenovirus type	12
this is a	12
after the onset	12
for the first	12
of the rna	12
we did not	12
the rdrp tree	12
the regulation of	12
m gene product	12
required for the	12
were resuspended in	12
cells were fixed	12
mbcs reactive to	12
at a multiplicity	12
and characterization of	12
of m pro	12
lookup suppl doi	12
of onward transmission	12
mouse model of	12
have shown that	12
the study of	12
org lookup suppl	12
evolution of the	12
shown to be	12
to the s	12
identification of a	12
found at http	12
segmented filamentous bacteria	12
the removal of	12
of the rdrp	12
group a streptococcus	12
infected c bl	12
from h n	12
the severity of	12
innate and adaptive	12
vesicular stomatitis virus	12
role of the	12
have been deposited	12
the detection of	12
to understand the	12
activity against sars	12
with respect to	12
replication of the	12
of de genes	12
and in vitro	12
the influenza virus	12
on the cell	12
and l of	12
the dimer interface	12
of respiratory disease	12
differential expression of	12
cov m gene	12
experiments were performed	12
a critical role	12
been shown that	12
virus replication in	12
onset of symptoms	12
mediated by the	12
in vivo and	12
pandemic influenza a	12
immune responses to	12
potential pandemic pathogens	12
of the immune	12
are required for	12
the ebola virus	12
correlated with the	12
patients with severe	12
room temperature for	12
the risk of	12
higher than that	12
likely to be	12
adaptive immune responses	12
could also be	12
in the upper	12
depending on the	12
and in vivo	12
as a control	12
was obtained from	11
end of the	11
major histocompatibility complex	11
reactive to the	11
and incubated with	11
acid and pl	11
vitro and in	11
branches of the	11
these results indicate	11
the national institutes	11
is responsible for	11
the likelihood of	11
at and hpi	11
we observed that	11
with fetal bovine	11
rnase l is	11
the small rna	11
was expressed with	11
antiviral activity of	11
in the spike	11
thermo scientific catalog	11
genes that were	11
from the national	11
were performed in	11
the course of	11
infection in a	11
recovered from the	11
to evaluate the	11
for the development	11
and influenza virus	11
isolation of a	11
determine whether the	11
development of a	11
been associated with	11
in h n	11
the same time	11
were harvested and	11
g for min	11
appear to be	11
peripheral blood mononuclear	11
it is also	11
for each sample	11
isolates of s	11
an increase in	11
a and c	11
in l of	11
the efficacy of	11
were added to	11
escape of a	11
incubated for h	11
pkr mrna levels	11
the existence of	11
the first time	11
of fatty acid	11
cells were harvested	11
the treatment of	11
coexpression of nsp	11
cells were then	11
we also thank	11
of the n	11
virus h n	11
the setting of	11
demonstrated that the	11
with pneumonia in	11
the e gene	11
mutations in nsp	11
viral small rnas	11
indicated that the	11
mouse hepatitis virus	11
and incubated at	11
the need for	11
pandemic influenza virus	11
cytokine and chemokine	11
in convalescent subjects	11
care and use	11
we compared the	11
the numbers of	11
and pl synthesis	11
to characterize the	11
crystal structure of	11
was performed by	11
of the viruses	11
to the virus	11
and g ml	11
than in the	11
we observed a	11
of dsrna viruses	11
is essential for	11
remains to be	11
were maintained in	11
novel coronavirus from	11
r ko mice	11
by flow cytometry	11
infected with sars	11
was present in	11
small rnas in	11
contributed to the	11
has shown that	11
with the same	11
tigers and lions	11
is based on	11
the replication of	11
were collected from	11
titers in the	11
was used for	11
at and dpi	11
overlapped with annotated	11
in the setting	11
igg against the	11
views of the	11
potential pandemic pathogen	11
p value of	10
removal of the	10
that may be	10
global rna virome	10
for h and	10
found at https	10
by the presence	10
bl j mice	10
member of the	10
showed that the	10
were compared using	10
of the network	10
analysis of a	10
cells were treated	10
genbank accession no	10
in mammalian cells	10
led to a	10
the construction of	10
one or more	10
activity of the	10
a wide range	10
united states and	10
none of the	10
component of the	10
to confirm the	10
a series of	10
in the middle	10
signs of disease	10
in balb c	10
transmission of influenza	10
to reduce the	10
was detected by	10
found that the	10
influenza viruses in	10
health care workers	10
min at room	10
regions of the	10
and replication of	10
for a single	10
oas and oas	10
brief exposure to	10
amino acid sequence	10
mhc class i	10
to further confirm	10
a subset of	10
referred to as	10
onward transmission from	10
recovered from horses	10
was associated with	10
host gene expression	10
rnase l activation	10
a recent study	10
cells exposed to	10
hek et cells	10
novel potential pandemic	10
tumor necrosis factor	10
on the other	10
important to note	10
function as a	10
the ko mice	10
the upregulation of	10
insertion of the	10
used for the	10
in part by	10
the interaction of	10
can be used	10
influenza virus infections	10
viruses of the	10
with m pro	10
of a laboratory	10
data set s	10
of which are	10
the alphavirus supergroup	10
is mediated by	10
coronavirus associated with	10
were determined using	10
at late times	10
tracheal wash fluid	10
of proinflammatory cytokines	10
by the use	10
cd t cells	10
to note that	10
of the most	10
northern blot analysis	10
development of an	10
nsp viroporin activity	10
cells were plated	10
had no effect	10
associated with a	10
were differentially expressed	10
view of the	10
was replaced with	10
results demonstrate that	10
following infection with	10
that can be	10
viral rna synthesis	10
was confirmed by	10
protein of sars	10
with those of	10
gain of function	10
likely due to	10
wide range of	10
the erasmus mc	10
important role in	10
see materials and	10
the complement pathway	10
show that the	10
lungs of the	10
was carried out	10
were normalized to	10
in the first	10
the discovery of	10
pkr protein levels	10
it is difficult	10
virus between ferrets	10
as a novel	10
there is a	10
assays were performed	10
domain of the	10
veroe cells were	10
kindly provided by	10
downregulated at hpi	10
t cells in	10
of the major	10
identification of the	10
the ferret model	10
for virus replication	10
the impact of	10
contribute to the	10
of the ferret	10
given that the	10
contrast to the	10
medium supplemented with	10
gene expression in	10
included in the	10
strand rna viruses	10
amino acids to	10
that there are	10
of m protein	10
response to virus	10
a group of	10
of pkr mrna	10
regulation of the	10
infection in the	10
these results suggest	10
and cultured in	10
were transferred to	10
sequence of the	10
the e protein	10
it is likely	10
for disease control	10
an rna virus	10
presence of a	10
we demonstrate that	10
the nsp nsp	10
the debate and	9
were collected and	9
absence of the	9
modified eagle medium	9
of the tree	9
research on influenza	9
we note that	9
of small rna	9
in situ hybridization	9
reconstitution inflammatory syndrome	9
glycans on gp	9
is inhibited by	9
small rna libraries	9
have not been	9
the spike gene	9
average log fc	9
immunized with combo	9
of ebola virus	9
in the erasmus	9
the m protein	9
linked immunosorbent assay	9
n virus in	9
the results were	9
novel human coronavirus	9
receptor binding site	9
the virus to	9
were similar to	9
venezuelan equine encephalitis	9
coronavirus from a	9
at this time	9
lower respiratory tract	9
public health risks	9
clinical signs of	9
pl and lps	9
g ml of	9
be associated with	9
in cynomolgus macaques	9
construction of a	9
available upon request	9
the activity of	9
viral replication and	9
is shown in	9
to be a	9
than those of	9
this suggests that	9
performed using the	9
of influenza viruses	9
into hek t	9
hpai h n	9
of a single	9
respiratory droplet transmission	9
university of north	9
of the fatty	9
total rna was	9
rnase l during	9
was found to	9
that overlapped with	9
together with the	9
tlr and tlr	9
the transmission of	9
immune response in	9
the most likely	9
of the other	9
and incubated for	9
were isolated by	9
between the two	9
confirmed that the	9
see the supplemental	9
stained with hematoxylin	9
formation of dmvs	9
to viral infection	9
in cultured cells	9
it is unclear	9
were immunized with	9
blood mononuclear cells	9
and evolution of	9
was due to	9
of the epidemic	9
cells were stained	9
the most relevant	9
length infectious cdna	9
case fatality rate	9
at h posttransfection	9
against the sars	9
demonstrate that the	9
the sequences of	9
titers were determined	9
derived from the	9
at the university	9
late times postinfection	9
african green monkey	9
but not the	9
specific t cells	9
were seeded in	9
the amino acid	9
in the viral	9
boas and boas	9
used as the	9
morbidity and mortality	9
in accordance with	9
mouth disease virus	9
the m gene	9
the receptor binding	9
and cells were	9
rna viruses and	9
the endoplasmic reticulum	9
active against sars	9
of clinical signs	9
is necessary for	9
group a streptococcal	9
t cell response	9
igg mbcs reactive	9
as described in	9
used to generate	9
and infected with	9
loss of the	9
deformed wing virus	9
to induce dmv	9
syndrome coronavirus in	9
by using the	9
the rest of	9
of the pbs	9
were fixed with	9
the outcome of	9
provide protection against	9
were analyzed by	9
genome sequence of	9
or aerosols between	9
is difficult to	9
differences in the	9
g ml streptomycin	9
isolates recovered from	9
replication in the	9
against the s	9
protein kinase pkr	9
were defined as	9
virus transmission between	9
was isolated from	9
rab and rab	9
and vero cells	9
the analysis of	9
we were able	9
to the sars	9
equine encephalitis virus	9
in this article	9
of the national	9
is important for	9
pneumonia in saudi	9
increase in the	9
vivo and in	9
infected with a	9
with g ml	9
in mice and	9
s subunit of	9
cell culture medium	9
the other hand	9
the viral rna	9
the prevalence of	9
avian h n	9
and pandemic preparedness	9
cd expression in	9
for in vitro	9
of the order	9
addition to the	9
from a man	9
rnase l and	9
has been previously	9
induce dmv formation	9
are associated with	9
performed as previously	9
a man with	9
were unable to	9
cells were exposed	9
was found in	9
of gp n	9
concentrations of ppgpp	9
of hepatitis c	9
lungs of mice	9
were incubated for	9
expression levels of	9
distribution of the	9
immune reconstitution inflammatory	9
and analyzed by	9
in the host	9
increased delivery of	9
at g ml	9
to study the	9
in the pathogenesis	9
the increase in	9
h n infection	9
said that they	9
virus infection and	9
but not by	9
led to the	9
not affect the	9
of north carolina	9
phylogenetic analysis of	9
further confirm the	9
most closely related	9
aerosols between ferrets	9
n influenza viruses	9
evidence that the	9
the immune system	9
respiratory disease in	9
differentially expressed mirnas	9
to assess the	9
of these viruses	9
at least three	9
number of years	9
these data demonstrate	9
membrane insertion of	9
man with pneumonia	9
is likely to	9
for analysis of	8
in the laboratory	8
some of these	8
reverse genetics system	8
cd surface expression	8
hek and vero	8
well as in	8
medium was replaced	8
one of these	8
syndrome coronavirus infection	8
in a previous	8
in the infected	8
were included in	8
of the er	8
control and prevention	8
were associated with	8
to examine the	8
which has been	8
bl mefs were	8
at days postinfection	8
host immune response	8
inhibition of the	8
and wt mice	8
the function of	8
a range of	8
was extracted from	8
receptor binding domain	8
in comparison to	8
of putative small	8
for pkr degradation	8
of human parainfluenza	8
to our knowledge	8
increased levels of	8
in mice infected	8
personal protective equipment	8
are critical for	8
may have been	8
results of the	8
we confirmed that	8
to those in	8
elapsed time for	8
of avian influenza	8
in expression of	8
health risks revisited	8
rift valley fever	8
critical role in	8
after influenza virus	8
of the lungs	8
indicate that the	8
is known that	8
processing of the	8
rather than the	8
expression of nsp	8
recombinant parainfluenza virus	8
debate and research	8
deposited in genbank	8
in case of	8
were analyzed for	8
the site of	8
first time that	8
transmission between ferrets	8
of the hn	8
cleavage of the	8
and h postinfection	8
been reported in	8
were grown in	8
material is available	8
be able to	8
of porcine epidemic	8
were performed with	8
infection in cis	8
this work was	8
p x ko	8
were used as	8
min of incubation	8
the national institute	8
h at room	8
compared to mock	8
exception of the	8
basis of the	8
insights into the	8
hn dimer interface	8
were measured by	8
mirna expression changes	8
of the first	8
could not be	8
levels of igg	8
polymerase chain reaction	8
to test whether	8
sequencing of the	8
dmem supplemented with	8
has previously been	8
need to be	8
text s in	8
cells were seeded	8
human airway epithelial	8
a factor of	8
binding of niv	8
supplemental material is	8
lungs of c	8
and treated with	8
it is known	8
hematoxylin and eosin	8
of vero cells	8
in agreement with	8
responses to sars	8
and does not	8
we examined the	8
are present in	8
did not affect	8
available in the	8
a mouse model	8
was performed to	8
in this model	8
by confocal microscopy	8
difference between the	8
tissues of the	8
to work on	8
erasmus mc facility	8
combo formulated with	8
from his laboratory	8
but did not	8
number of reads	8
as early as	8
cd t cell	8
als p and	8
play a role	8
the virus was	8
with pl flux	8
were fixed in	8
ph n and	8
of the university	8
were generated using	8
lower than that	8
nature of the	8
samples collected from	8
s protein of	8
consistent with our	8
in nsp and	8
in the er	8
centers for disease	8
to multiple nucleoside	8
of the wt	8
as the primary	8
were analyzed using	8
furin cleavage site	8
weight loss and	8
the functions of	8
mice were infected	8
mutation in the	8
to the small	8
of the family	8
and mortality in	8
were performed as	8
bmdcs from sfb	8
the sensitivity of	8
ko and wt	8
deletion of the	8
probability of onward	8
contact with the	8
appears to be	8
samples were collected	8
was purchased from	8
is likely that	8
by using a	8
in the ko	8
of the ifn	8
virus replication and	8
to have been	8
infection with influenza	8
the lethal dose	8
were stimulated with	8
at day p	8
of pandemic influenza	8
to test the	8
accession number gse	8
supplemented with fbs	8
human and mouse	8
upper and lower	8
performed to detect	8
the infectivity and	8
three times with	8
medium was added	8
analysis was performed	8
and it is	8
of the innate	8
the primary antibody	8
of c bl	8
based on a	8
risks and benefits	8
that at least	8
and research pause	8
at the level	8
rnase l in	8
of a potential	8
of infected cells	8
of the annotated	8
specificity of the	8
at least two	8
strongly suggest that	8
have also been	8
receptor for the	8
similar to the	8
affected by the	8
been reported to	8
the distribution of	8
after infection with	8
of the disease	8
is sufficient to	8
in ml of	8
significantly higher than	8
the large number	8
is available online	8
and nsp are	8
is a major	8
the hypothesis that	8
the increased delivery	8
we used the	8
that they are	8
in the network	8
western blot analysis	8
cov m protein	8
a measure of	8
it would be	8
a large number	8
to be highly	8
elevation of ca	8
to generate the	8
we investigated the	8
mhc class ii	8
we demonstrated that	8
this time point	8
by the virus	8
cov infectious cdna	8
from those of	8
supported by the	8
a highly pathogenic	8
and then incubated	8
in the literature	8
it will be	8
depends on the	8
transcriptome sequencing analysis	8
seem to be	8
were expressed in	8
a member of	8
a model of	8
isolated from humans	8
weeks after the	8
important for the	8
at hpi and	8
has also been	8
we showed that	8
w a mutant	8
with hematoxylin and	8
temperature for min	8
to bind to	8
available online only	8
using the following	8
in the hn	8
were found in	8
the same as	8
higher levels of	8
infection in mice	8
and should be	8
in the serum	8
we have shown	8
disease control and	8
was able to	8
response to the	8
an outbreak of	8
response in the	8
antigen presentation pathway	8
murine hepatitis virus	8
glycan array screening	8
in the nsp	8
viruses isolated from	8
is an important	8
lungs of sars	8
transmission of the	8
formation of the	8
be required to	8
glycans on the	7
structural and functional	7
cell responses against	7
suggesting that it	7
e protein in	7
in the wild	7
a decrease in	7
functional receptor for	7
and development of	7
is a functional	7
of the manuscript	7
have been shown	7
animal care and	7
that the virus	7
represents the mean	7
was analyzed by	7
do not know	7
driving force for	7
infected cells and	7
we determined the	7
amino acid identity	7
rectal swabs were	7
mrna bound to	7
the reaction products	7
the effectiveness of	7
mice compared to	7
effects of the	7
its role in	7
were harvested at	7
the history of	7
to the human	7
each time point	7
airway epithelial cells	7
the virus and	7
well of a	7
a p value	7
of cynomolgus macaques	7
was funded by	7
with ml of	7
differences between the	7
infectious cdna of	7
m pore size	7
of the coronavirus	7
susceptible to the	7
infection with sars	7
of differentially expressed	7
at a time	7
mechanisms by which	7
revealed that the	7
trsv isolates from	7
to generate a	7
in our study	7
samples from the	7
would be expected	7
the idea that	7
implications for the	7
our data suggest	7
titers in nasal	7
a receptor for	7
does not necessarily	7
to the viral	7
each of these	7
dependent rna polymerases	7
lung injury and	7
upregulation of the	7
protease inhibitor cocktail	7
patients with covid	7
s proteins of	7
of rna release	7
of p x	7
loci that overlapped	7
infected cells were	7
to ensure that	7
at the indicated	7
for entry into	7
the changes in	7
genes de at	7
suggested that the	7
class of small	7
multiple nucleoside analogues	7
hdpp ki mice	7
not in the	7
department of health	7
the veroe cells	7
of the e	7
the international committee	7
infected with pfu	7
the combination of	7
in the ferret	7
to the same	7
genes of unknown	7
viruses in the	7
is present in	7
biosafety and biosecurity	7
with severe acute	7
in hela cells	7
infection with a	7
into vero cells	7
small nucleolar rnas	7
h n challenge	7
after h of	7
the st strain	7
in the human	7
absence of complement	7
of the debate	7
or h n	7
in at least	7
small rnas and	7
the value of	7
infected p x	7
of the hcov	7
transmission via respiratory	7
protein kinase r	7
with nl virus	7
veroe cells and	7
serum samples were	7
performed on a	7
small rnas are	7
the hn protein	7
the origin of	7
to induce the	7
the result of	7
bl j and	7
do not necessarily	7
after min of	7
seen in the	7
a single lab	7
not appear to	7
we conclude that	7
cov and mers	7
we do not	7
a community lai	7
the virus titers	7
as in the	7
in the mld	7
thought to be	7
and middle east	7
influenza risk assessment	7
and lower respiratory	7
in some cases	7
quantitative reverse transcription	7
analyses were performed	7
herpes simplex virus	7
small number of	7
not seem to	7
infected or infected	7
signs of respiratory	7
bone marrow cells	7
of the interferon	7
bat roni cells	7
resuspended in l	7
pedv pc a	7
complete genome sequence	7
by northern blot	7
cells were maintained	7
on the same	7
followed by a	7
pseudotyped viral particles	7
cov and hcov	7
we show that	7
taxonomy of viruses	7
hn h q	7
length cdna clone	7
was mixed with	7
supported in part	7
studies on influenza	7
found in a	7
small rna locus	7
of the authors	7
into hek et	7
is not required	7
students and postdoctoral	7
with acute respiratory	7
interferon regulatory factor	7
as part of	7
is similar to	7
high concentrations of	7
total number of	7
tobacco ringspot virus	7
value represents the	7
may function as	7
supernatants were harvested	7
of the samples	7
accordance with the	7
in conjunction with	7
and adaptive immune	7
research of concern	7
use of highly	7
isolates were recovered	7
the next day	7
rnase l pathway	7
data show that	7
the finding that	7
from each cluster	7
of streptococcus equi	7
was purified from	7
lead to the	7
in rpmi medium	7
not essential for	7
in roni cells	7
the structure of	7
of the full	7
have been described	7
that were not	7
was extracted using	7
the notion that	7
to calculate the	7
number of de	7
select agent theft	7
transfected cells were	7
we thank the	7
to endo h	7
context of the	7
as a result	7
to severe acute	7
as a vaccine	7
enhanced green fluorescent	7
resulted in the	7
and loss of	7
the crystal structure	7
from the cell	7
and table s	7
and postdoctoral fellows	7
that this is	7
host and viral	7
of this virus	7
used to identify	7
and use committee	7
ability of the	7
prior to the	7
the concentration of	7
we were unable	7
of potential pandemic	7
coexpression of sars	7
rna copy numbers	7
was subjected to	7
indicating that m	7
functional analysis of	7
caused by a	7
the tigers and	7
was calculated as	7
than in those	7
for activation of	7
with l of	7
resulting in the	7
overall clinical scores	7
in the golgi	7
sufficient to induce	7
the frequency of	7
a result of	7
the ancestor of	7
results suggested that	7
for binding to	7
work was supported	7
at hpi in	7
of which were	7
the authors and	7
we could detect	7
and did not	7
h n avian	7
via posttranslational control	7
function of the	7
or influenza virus	7
vero cells were	7
case of lai	7
protective efficacy of	7
of the t	7
a function of	7
with a anhui	7
j and c	7
genetic analysis of	7
infection and the	7
virus a anhui	7
concentrations of the	7
in this report	7
these results demonstrate	7
it is a	7
of human respiratory	7
the sars coronavirus	7
severe respiratory disease	7
of test compounds	7
to be the	7
the rbd and	7
the wt mice	7
immune responses in	7
play an important	7
of the four	7
entry mediated by	7
s b and	7
characteristics of the	7
infection with hcov	7
to address this	7
total pkr mrna	7
within the gp	7
for the formation	7
influenza virus in	7
stranded rna viruses	7
the mechanism of	7
data were analyzed	7
than that of	7
the quality of	7
supported by nih	7
and can be	7
of the s	7
is not known	7
necrosis factor alpha	7
animal and human	7
a mixture of	7
the potential for	7
receptor p x	7
virus ns protein	7
the driving force	7
of mouse adenovirus	7
innate immune responses	7
consistent with a	7
impact of the	7
it was shown	7
associated molecular patterns	7
change in the	7
a lab escape	7
memory b cell	7
h n in	7
is used to	7
clinical samples and	7
we sought to	7
plays a role	7
of health and	7
the control of	7
virus transmission via	7
are predicted to	7
was performed in	7
from clinical samples	7
result of a	7
and public health	7
was performed as	7
a vaccine candidate	7
side of the	7
that some of	7
that m protein	7
were derived from	7
with influenza a	7
of the ebola	7
protein was detected	7
on ebov gp	7
the consequences of	7
in the gp	7
n virus between	7
a study of	7
de at hpi	7
in the cytoplasm	7
a functional receptor	7
reaction products were	7
the glycan determinants	7
in wt cells	7
hold at b	6
are involved in	6
was amplified by	6
and centrifuged at	6
and the number	6
that the oas	6
were expressed with	6
consistent with this	6
be used for	6
not necessarily reflect	6
was measured by	6
vero e cells	6
two time points	6
were classified as	6
hattori et al	6
removed from the	6
r sv mefs	6
human cases of	6
combined with the	6
infected ko mice	6
infection of a	6
to this end	6
and used for	6
infection of caco	6
in parallel with	6
upstream of rna	6
protein in trans	6
other bee viruses	6
the views of	6
on the glycan	6
university of washington	6
replication and pathogenesis	6
the elevation of	6
purified using a	6
mice were euthanized	6
and pathogenesis of	6
lab escape of	6
that they were	6
to facilitate the	6
disease in humans	6
accumulation of the	6
viral replication in	6
on taxonomy of	6
of both the	6
majority of the	6
mm by mm	6
s b in	6
for more than	6
cd ko mice	6
pandemic influenza viruses	6
in the evolution	6
in human airway	6
affinity of the	6
of cytoplasmic ca	6
posttranslational control of	6
and human services	6
of bone marrow	6
studies in the	6
of the middle	6
and in the	6
data demonstrate that	6
the cdna clone	6
the transduction of	6
the interaction between	6
antibody responses to	6
the internal proteins	6
not result in	6
was performed for	6
of infectious diseases	6
in the gut	6
proteins that are	6
be used as	6
at day postinfection	6
of the original	6
amplified by pcr	6
the icelandic horse	6
to ph n	6
be involved in	6
the probability that	6
of mhc class	6
immunization with piv	6
cultured in rpmi	6
glycan cap and	6
time reverse transcription	6
were performed on	6
cells with a	6
with h n	6
gp and furin	6
reports in the	6
amino acid sequences	6
the dsrna viruses	6
it does not	6
our data indicate	6
the molecular mechanisms	6
from each animal	6
defined by the	6
caused by the	6
a role for	6
of complement signaling	6
of the cell	6
infected mice were	6
whether or not	6
s a and	6
in these studies	6
viral rna was	6
with regard to	6
a virus infection	6
dominant negative mutants	6
have to be	6
evaluation of the	6
has been proposed	6
protection against e	6
on the viral	6
evolution of rna	6
than that in	6
the results from	6
may not be	6
loss and release	6
of e protein	6
these genes were	6
pl synthesis pathways	6
binding site ii	6
virus infections in	6
small interfering rna	6
at both time	6
against severe acute	6
were selected for	6
properties of the	6
piv expressing mers	6
using superscript iii	6
primary peritoneal macrophages	6
h n ha	6
genbank accession number	6
epidemic of respiratory	6
performed as described	6
can also be	6
is that the	6
on at least	6
and tracheal wash	6
rpmi medium supplemented	6
from the full	6
course of infection	6
as a consequence	6
to each other	6
as a function	6
red blood cells	6
reactive igg mbcs	6
at the site	6
purinergic receptor p	6
be due to	6
for min to	6
of infection with	6
be important for	6
a previous study	6
seasonal influenza viruses	6
disruption of the	6
for the virus	6
data have been	6
the antigen presentation	6
be sufficient to	6
to the formation	6
times with pbs	6
libraries were prepared	6
in less than	6
cells were grown	6
the most abundant	6
putative small rnas	6
amino acid residues	6
significant increase in	6
the magnitude of	6
analysis of variance	6
deep sequencing of	6
infected with nl	6
small rnas from	6
study of the	6
the elapsed time	6
committee on taxonomy	6
enterica serovar typhi	6
analyzed for the	6
when march was	6
to provide protection	6
of igg mbcs	6
reported to be	6
for growth in	6
to better understand	6
are likely to	6
later times postinfection	6
to be important	6
were analyzed with	6
genome sequences of	6
transmission of h	6
infection results in	6
in cells infected	6
graduate students and	6
igg titers against	6
ends of the	6
bound to the	6
convalescent subjects than	6
lethal dose of	6
and analysis of	6
nsp or nsp	6
into the cell	6
could be detected	6
challenge in mice	6
that have been	6
tmprss cells were	6
e b k	6
influenza virus ns	6
be related to	6
rbd and s	6
out of the	6
increased resistance to	6
expression of gp	6
in nasal swabs	6
the virus in	6
the nature of	6
during viral infection	6
in our analysis	6
small rna cloning	6
were allowed to	6
and epa p	6
health and human	6
assembly of the	6
to the lack	6
determined using the	6
and veroe tmprss	6
genes related to	6
activated protein kinase	6
for providing the	6
as a potential	6
under conditions of	6
like receptor signaling	6
undetected or unreported	6
for dmv formation	6
of ebov gp	6
pkr depletion by	6
level of the	6
primer sequences are	6
these data indicate	6
with g of	6
could have been	6
of the pandemic	6
urokinase pathway in	6
an animal model	6
of cd expression	6
derived small rnas	6
the d g	6
human respiratory syncytial	6
in a dose	6
international committee on	6
washed with pbs	6
valley fever virus	6
infected and infected	6
compared with those	6
necessarily reflect the	6
higher than the	6
that did not	6
possible that the	6
of a new	6
vero a and	6
viruses evolved from	6
gene expression profiles	6
m gene products	6
rna was harvested	6
to b in	6
were significantly higher	6
mice were used	6
are not well	6
among rna viruses	6
infected with mers	6
molecular basis for	6
of group a	6
about the debate	6
infected cells was	6
nonessential amino acids	6
min and then	6
levels of the	6
the entry of	6
not statistically significant	6
the influence of	6
previous work has	6
in this work	6
in humans and	6
histocompatibility complex class	6
levels of pkr	6
with cryptococcal meningitis	6
n avian influenza	6
sought to determine	6
the genome of	6
and subjected to	6
deviation from three	6
and ebola virus	6
by the unc	6
in the face	6
adaptive immune response	6
that activation of	6
is a common	6
protein expression in	6
entry depends on	6
to address the	6
incubated for min	6
of membrane synthesis	6
by quantitative reverse	6
glycans attached to	6
i and ii	6
the availability of	6
broad range of	6
and the cells	6
also contribute to	6
dynamin and clathrin	6
appear to have	6
and virulence of	6
visualization of the	6
leads to a	6
of sars coronavirus	6
be explained by	6
differences were observed	6
listed in table	6
the causative agent	6
to the er	6
the observation that	6
of zippered er	6
for detection of	6
is independent of	6
small rnas that	6
were not detected	6
of the orf	6
which are not	6
cells were collected	6
was analyzed using	6
the purinergic receptor	6
viruses that are	6
and others have	6
only a few	6
sequencing analysis of	6
serve as a	6
rna loci that	6
may have a	6
small rna transcriptome	6
pathogenic h n	6
of less than	6
henipavirus infection in	6
suppression of t	6
there has been	6
appeared to be	6
we are grateful	6
genes associated with	6
old c bl	6
that results in	6
oas protein expression	6
of incubation at	6
in influenza virus	6
the total number	6
each value represents	6
origin influenza a	6
that could be	6
in the tigers	6
an analysis of	6
b in the	6
during viral isolation	6
cells pretreated with	6
subjects than in	6
of igg against	6
in veroe cells	6
this is not	6
seasonal h n	6
the transfected cells	6
proteins such as	6
our results suggest	6
allowed us to	6
the set of	6
and release reports	6
diffuse alveolar damage	6
samples were analyzed	6
reported that the	6
human and animal	6
factors associated with	6
at least in	6
involving pathogens with	6
bat and human	6
lymphocytic choriomeningitis virus	6
in line with	6
in a mixture	6
influenza virus and	6
lgi network of	6
did not significantly	6
absence of c	6
cell activation and	6
of deformed wing	6
of the genes	6
that were differentially	6
see also table	6
cd expression on	6
cov spike protein	6
mouse reference genome	6
infections in the	6
these results suggested	6
not have a	6
size of the	6
viral isolates were	6
effect of the	6
stranded rna virus	6
in pbs with	6
for at least	6
different from those	6
the active site	6
may be used	6
of the cellular	6
upstream of the	6
calculated using the	6
were calculated as	6
use research of	6
correlates of protection	6
the kinetics of	6
in the genome	6
of the predicted	6
of neutralizing antibodies	6
are grateful to	6
the apical surface	6
against invasive gas	6
loci overlapped with	6
of honey bee	6
used in this	6
for min with	6
can lead to	6
of a h	6
bacterial and viral	6
cov infection in	6
has been observed	6
to interact with	6
were approved by	6
ng of pcaggs	6
during influenza virus	6
gene set enrichment	6
is not the	6
increased doses of	6
upper respiratory tract	6
and cloned into	6
reported to the	6
to analyze the	6
and do not	6
during the epidemic	6
more similar to	6
at and h	6
spread of sars	6
to be associated	6
dependent on the	6
the inhibition of	6
with the sars	6
proteins encoded by	6
in the natural	6
associated with severe	6
fuscus skin fibroblasts	6
the egyptian rousette	6
of the total	6
by addition of	6
the major branches	6
in the research	6
a virus in	6
a and huh	6
in a single	6
for each of	6
nd nd nd	6
this type of	6
each cluster were	6
by nih grant	6
release reports in	6
no significant differences	6
a novel human	6
bl mice were	6
glycans in the	6
in both the	6
to detect the	6
that are not	6
observed a significant	6
the differences in	6
were identified in	6
were washed and	6
molecular basis of	6
with combo smq	6
the circular profiles	6
in ferrets and	6
case of the	6
the extent of	6
of viral infection	6
were isolated from	6
we also examined	6
seasonal influenza virus	6
were transiently transfected	6
is critical for	6
the host immune	6
provided by the	6
gene expression omnibus	6
infections in humans	6
aspects of the	6
the ratio of	6
a new coronavirus	6
from three independent	6
ucsc genome browser	6
highly pathogenic influenza	6
the cell culture	6
of the m	6
may be a	6
eptesicus fuscus skin	6
required for pkr	6
the result is	6
parainfluenza virus expressing	6
in the lethal	6
both time points	6
standard deviation from	6
molecularly based surveillance	6
and found that	6
structural basis for	6
vero cells infected	6
the presence and	6
the sequence of	6
resistance to multiple	6
perspective on the	6
cells of the	6
h n vaccine	6
were present in	6
in the rna	6
proteins of the	6
binding of the	6
a broad range	6
variation in the	6
been reported that	6
the infectivity of	6
genomic characterization of	6
of the severe	6
was not detected	6
in this regard	6
could be used	6
more sensitive to	6
for human emergence	6
in hong kong	6
diversity of rna	6
protein of the	6
this study was	6
of the genomic	6
any of the	6
the face of	6
highly pathogenic h	6
rna was purified	6
we evaluated the	6
as assessed by	6
with the presence	6
binding of n	6
salmonella enterica serovar	6
in text s	6
k r sv	6
is the first	6
induced acute lung	6
dc in the	6
a review of	6
cytopathic effect of	6
in recent years	6
the background of	6
likely that the	6
infected with influenza	6
hcv patient plasma	6
of pbs u	6
as a negative	6
of the infected	6
sequences of the	6
in the study	6
and benefits of	6
of the membrane	6
in the virus	6
gene expression data	6
effective against the	6
viroporin domain is	6
influenza h n	6
of viral replication	6
and ph n	6
and influenza a	6
dependent protein kinase	6
not well understood	6
well plates were	6
to late endosomes	6
which have been	6
determined by plaque	6
monitoring select agent	6
the capacity of	6
with co for	5
were predicted to	5
address this issue	5
prompted us to	5
discovery of a	5
isolation and characterization	5
and varroa mites	5
collected from the	5
been observed in	5
involved in this	5
of the individual	5
such as influenza	5
indicating that they	5
pc a strain	5
the choice of	5
the ucsc genome	5
a significant increase	5
a common ancestor	5
serum samples from	5
determine if the	5
are also likely	5
m and np	5
rna viruses in	5
viruses and their	5
with a full	5
in vitro stimulation	5
in the number	5
proteins in the	5
a potential pandemic	5
to the lung	5
as indicated by	5
branch consists of	5
host range and	5
it was recently	5
of the small	5
catalytic domain of	5
reverse genetics with	5
the appearance of	5
is the most	5
memory t cells	5
ml of penicillin	5
human infections in	5
better understanding of	5
as described for	5
viral titers were	5
was required for	5
to investigate whether	5
early and late	5
which can be	5
infection of the	5
based on their	5
alteration of the	5
human coronavirus emc	5
to weeks after	5
rna from the	5
to rule out	5
sh and hn	5
but not with	5
set enrichment analysis	5
the infectious cdna	5
min hold at	5
by expression of	5
for the generation	5
are shown as	5
of mycobacterium tuberculosis	5
related to those	5
nucleotides of the	5
of human immunodeficiency	5
mock infected or	5
of the families	5
n h n	5
has led to	5
influenza viruses and	5
have been used	5
days and postinfection	5
for the emerging	5
risk and elapsed	5
and nsp were	5
and n proteins	5
generation of a	5
was performed with	5
were downloaded from	5
use of the	5
of the research	5
these and other	5
b cell responses	5
tissue culture infective	5
public health benefits	5
calculation of risk	5
the mrna level	5
of a conserved	5
to the development	5
associated with acute	5
pellets were resuspended	5
transiently transfected into	5
of the test	5
supernatants were collected	5
we speculate that	5
and the virus	5
of a lab	5
mg kg of	5
for viral rna	5
derived from mice	5
ebov gp and	5
microrna host genes	5
there may be	5
colonized with sfb	5
quality of the	5
have demonstrated that	5
as a measure	5
ebov entry into	5
immunized with pfu	5
are important for	5
alignment of the	5
mutants were expressed	5
were related to	5
neutrophils in the	5
cov ma pathogenesis	5
the capsid protein	5
have the same	5
the scientific community	5
to be more	5
to a global	5
rna viruses have	5
the s proteins	5
in combination with	5
were euthanized at	5
of the arterivirus	5
functional and structural	5
the catalytic domain	5
the sample was	5
for murine coronavirus	5
genetic changes inventory	5
lectin binding intensity	5
significantly higher in	5
of plant viruses	5
the size of	5
dipeptidyl peptidase is	5
measure of the	5
e orf and	5
were washed with	5
from sample sc	5
in vero a	5
of pkr is	5
compared with the	5
comparative analysis of	5
cell culture supernatants	5
pkr mrna bound	5
as a tool	5
cellular immune responses	5
significant reduction in	5
from patients with	5
u ml of	5
and may be	5
also found that	5
positive for sars	5
many of these	5
pathogenesis of influenza	5
or in the	5
highlighted in the	5
drugs against sars	5
that the host	5
novel coronavirus associated	5
central nervous system	5
higher than those	5
epa p to	5
of the rdrps	5
unable to detect	5
and identification of	5
significant differences were	5
is equal to	5
and have been	5
in materials and	5
mild to marked	5
a source of	5
the receptor for	5
can serve as	5
as it is	5
l volume of	5
in the p	5
inflammatory cells in	5
were incubated at	5
characterized by the	5
to the plasma	5
antiviral activity by	5
of the population	5
and c a	5
cov and influenza	5
previously reported that	5
of viral proteins	5
this was not	5
nsp nsp cleavage	5
risk assessment of	5
of virus replication	5
cynomolgus macaques inoculated	5
in the integral	5
acp and c	5
was based on	5
its w a	5
ph n np	5
clathrin heavy chain	5
that were recovered	5
prevalence of trsv	5
members of a	5
at to dpi	5
a better understanding	5
the first step	5
was recently shown	5
was added at	5
a reverse genetics	5
national center for	5
analyzed using the	5
the opposing monomer	5
h q mutation	5
such as sars	5
decrease in the	5
recombinant viruses were	5
that the m	5
spr analysis of	5
the region of	5
ph n m	5
the process of	5
the membrane structures	5
from horses at	5
red infectious center	5
this is the	5
homology at the	5
stained in green	5
complement system is	5
for development of	5
nih national institute	5
human infection with	5
result is representative	5
were detected by	5
of body weight	5
by pcr using	5
the design of	5
in a mouse	5
no change in	5
associated with an	5
indicates that the	5
a murine model	5
was cotransfected with	5
of infected mice	5
secondary bacterial infections	5
are as follows	5
a consequence of	5
vero cells or	5
icelandic veterinary institute	5
the antiviral activity	5
and analyzed using	5
g of pcmv	5
interaction with the	5