This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.
| identifier | question |
|---|---|
| cord-000271-812uc4w7 | Down- regulation of the macrophage lineage through interaction with OX2( CD200) Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue- specific immune tolerance? |
| cord-297760-uzzuoy9v | Rational siRNA design for RNA interference An algorithm for selection of functional siRNA sequences Noise amidst the silence: off- target effects of siRNAs? |
| cord-000363-cbzd8ybv | what are the Est proteins doing? |
| cord-000881-s90geszi | A structural and primary sequence comparison of the viral RNA- dependent RNA polymerases Stabilization of poliovirus polymerase by NTP binding and fingers- thumb interactions Dynamics: the missing link between structure and function of the viral RNA- dependent RNA polymerase? |
| cord-000294-2g471tb4 | The complete atomic structure of the large ribosomal subunit at 2.4 A resolution Structures of the bacterial ribosome at 3.5 A resolution Structure of the 80S ribosome from Saccharomyces cerevisiae- tRNA- ribosome and subunit- subunit interactions Comprehensive molecular structure of the eukaryotic ribosome Crystal structure of the ribosome at 5.5 Å resolution Structures of the ribosome in intermediate states of ratcheting The process of mRNA- tRNA translocation The conserved A- site finger of the 23S rRNA: just one of the intersubunit bridges or a part of the allosteric communication pathway? |
| cord-000435-2u49b7xo | How can our results be reconciled with previous results which indicated that only the immediately 3 0-adjacent 1- 3 nt were relevant for RT in these viruses? |
| cord-302368-uhhtvdif | What then are some of the benefits of a selectively labeled sample when uniformly labeled samples have been shown to be adequate? |
| cord-262076-b5u5hp2r | confer HIV-1 resistance Human immunodeficiency virus type 1 escapes from RNA interference- mediated inhibition Inhibition of HIV-1 replication with designed miRNAs expressed from RNA polymerase II promoters Human immunodeficiency virus type 1 escape from RNA interference HIV-1 can escape from RNA interference by evolving an alternative structure in its RNA genome RNA interference as an antiviral approach: targeting HIV-1 Silencing of HIV-1 with RNA interference: a multiple shRNA approach Specific inhibition of human immunodeficiency virus type 1 replication by antisense oligonucleotides: an in vitro model for treatment Can hammerhead ribozymes be efficient tools to inactivate gene function? |
| cord-275859-ix8du1er | If the local stability of 3- 4 bp is sufficient to determine frameshift efficiency, why does the HIV-1 frameshift site stem- loop contain 11 Watson- Crick base pairs? |
| cord-048345-m56agj4z | How reliable are the binding site predictions returned by Gibbs sampling based TFBS identification algorithms? |
| cord-048345-m56agj4z | Regulation of genes encoding subunits of the trehalose synthase complex in Saccharomyces cerevisiae: novel variations of STRE- mediated transcription control? |
| cord-011565-8ncgldaq | Quikr: a method for rapid reconstruction of bacterial communities via compressive sensing MetaPalette: a k- mer painting approach for metagenomic taxonomic profiling and quantification of novel strain variation MISSION: ultra large- scale feature selection using count- sketches Large- scale machine learning for metagenomics sequence classification How much metagenomic sequencing is enough to achieve a given goal? |
| cord-263645-wupre5uj | What is functional and what is junk? |
| cord-302895-471zei5o | Nidovirus helicase: a role in post- transcriptional quality control of viral mRNAs? |
| cord-302895-471zei5o | The nsp10 C- terminal domain: coupling ATPase and helicase activities? |
| cord-284990-klsl1nzn | The ESAT-6/ WXG100 superfamily- and a new Gram- positive secretion system? |
| cord-308331-55ge7kmr | Why do RNA viruses recombine? |
| cord-320325-sjab8zsk | divalent metal ions either promote or inhibit enzymatic reactions? |
| cord-048478-ftlb5b95 | The role of 2 0-5 0 oligoadenylate- activated ribonuclease L in apoptosis RNase L- independent specific 28S rRNA cleavage in murine coronavirus- infected cells Programmed death in yeast as adaptation? |
| cord-048478-ftlb5b95 | rRNA degradation- apoptotic or not? |
| cord-334127-wjf8t8vp | Consensus proposals for a unified system of nomenclature of hepatitis C virus genotypes Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource Is there any value to hepatitis B virus genotype analysis? |
| cord-000293-pc4x5e24 | A mechanical explanation of RNA pseudoknot function in programmed ribosomal frameshifting Progress in antisense technology Morpholino oligos: making sense of antisense? |
| cord-000293-pc4x5e24 | The global structures of a wild- type and poorly functional plant luteoviral mRNA pseudoknot are essentially identical Correlation between mechanical strength of messenger RNA pseudoknots and ribosomal frameshifting Interaction of the HIV-1 frameshift signal with the ribosome Characterization of the mechanical unfolding of RNA pseudoknots Locked nucleic acid oligonucleotides: the next generation of antisense agents? |
| cord-000293-pc4x5e24 | towards clinical reality Antisense technology: a selective tool for gene expression regulation and gene targeting Chemical modification: the key to clinical application of RNA interference? |
| cord-314877-db7tze8j | A long- range RNA- RNA interaction between the 5 and 3 ends of the HCV genome A twist in the tail: SHAPE mapping of long- range interactions and structural rearrangements of RNA elements involved in HCV replication Hepatitis C virus RNA: molecular switches mediated by long- range RNA- RNA interactions? |
| cord-319116-2ts6zpdb | Elevated levels of G- quadruplex formation in human stomach and liver cancer tissues G- quadruplex- binding small molecules ameliorate C9orf72 FTD/ ALS pathology in vitro and in vivo G- quadruplex structures and their interaction diversity with ligands Structure, location and interactions of G- quadruplexes Telomere G- quadruplex as a potential target to accelerate telomere shortening by expanding the incomplete end- replication of telomere DNA Telomeric G- quadruplex architecture and interactions with potential drugs Human telomeric G- quadruplex: the current status of telomeric G- quadruplexes as therapeutic targets in human cancer Cell cycle regulation of G- quadruplex DNA structures at telomeres G- quadruplexes in human promoters: a challenge for therapeutic applications G4 DNA in ras genes and its potential in cancer therapy Small molecules targeting c- Myc oncogene: promising anti- cancer therapeutics Making sense of G- quadruplex and i- motif functions in oncogene promoters G- quadruplex structures in the human genome as novel therapeutic targets Targeting G- quadruplexes in gene promoters: a novel anticancer strategy? |
| cord-319116-2ts6zpdb | Targeting unimolecular G- quadruplex nucleic acids: a new paradigm for the drug discovery? |
| cord-319116-2ts6zpdb | radioresistance of D. radiodurans involves G4 DNA- mediated regulation Mapping and characterization of G- quadruplexes in Mycobacterium tuberculosis gene promoter regions G- quadruplexes in pathogens: a common route to virulence control? |
| cord-304794-z2kx314h | Dr Jekyll or Mr Hyde? |
| cord-304794-z2kx314h | The Bloom's syndrome helicase unwinds G4 DNA Genome- wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability Human papillomavirus G- quadruplexes Spectrum of Epstein- Barr virus- associated diseases Role for G- quadruplex RNA binding by Epstein- Barr virus nuclear antigen 1 in DNA replication and metaphase chromosome attachment G- quadruplexes regulate Epstein- Barr virus- encoded nuclear antigen 1 mRNA translation Targeting G- quadruplexes in gene promoters: a novel anticancer strategy? |
| cord-304794-z2kx314h | The guanine- quadruplex aptamer 93del inhibits HIV-1 replication ex vivo by interfering with viral entry, reverse transcription and integration Cellular uptake of ODNs in HIV-1 human- infected cells: a role for viral particles in DNA delivery? |
| cord-009318-zt1o1bcz | Do filter parameters exhibit the same LOD minima when using Bst 2.0, as they did for Bst 3.0? |
| cord-009318-zt1o1bcz | Fifth, we asked how is LOD impacted by the concentration of hgDNA? |
| cord-009318-zt1o1bcz | First, does the ROC curve for TTP display a clear optimum? |
| cord-009318-zt1o1bcz | First, we asked: Is there a relationship between fraction of template molecules amplified in dLAMP and amplification time? |
| cord-009318-zt1o1bcz | Fourth, we asked is maximum rate impacted by the concentration of hgDNA? |
| cord-009318-zt1o1bcz | If amplification initiation is stochastic, as observed in Figures 5F and 6A-B, does longer assay time increase'efficiency'and thereby improve LOD when using T m( as seen in Figure 7C and F)? |
| cord-009318-zt1o1bcz | Second, is there an advantage to using HRM in the final assay with Bst 2.0? |
| cord-009318-zt1o1bcz | Second, we asked what is the impact of hgDNA on efficiency as a function of time? |
| cord-009318-zt1o1bcz | Third, we asked what is the impact of hgDNA and time on non- specific amplification? |