This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.
| identifier | question |
|---|---|
| cord-001773-mqk0sx5n | The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury? |
| cord-016742-y7jgjera | Which of the following statements about the cardiovascular effects of norepinephrine is correct? |
| cord-002468-onpmkjaz | The role of the renin- angiotensin system in the development of cardiovascular disease Increased ACE 2 and decreased ACE protein in renal tubules from diabetic mice: a renoprotective combination? |
| cord-017585-0llgr357 | Comparison of omapatrilat and the novel neutral endopeptidase 24.11/ angiotensin- converting enzyme inhibitor GW796406 NF- kappaB- dependent increase in intrarenal angiotensin II induced by proteinuria Angiotensin-(1- 7) inhibits growth of cardiac myocytes through activation of the mas receptor Differential regulation of cardiac angiotensin converting enzyme 2( ACE2) and ACE by aldosterone Characterization of renal Angiotensin- converting enzyme 2 in diabetic nephropathy Developmental expression of ACE2 in the SHR kidney: A role in hypertension? |
| cord-282256-lqmixm7s | Can angiotensin receptor- blocking drugs perhaps be harmful in the COVID-19 pandemic? |
| cord-259933-ggx4v0bz | key: cord-259933-ggx4v0bz authors: Dalan, Rinkoo; Bornstein, Stefan R.; El- Armouche, Ali; Rodionov, Roman N; Markov, Alexander; Wielockx, Ben; Beuschlein, Felix; Boehm, Bernhard O. title: The ACE-2 in COVID-19: Foe or Friend? |
| cord-005931-iggkxbbf | Alcohol intake ANG II induces drinking, but does it induce alcohol drinking? |
| cord-005931-iggkxbbf | But, what about renin? |
| cord-277766-rxmpi61o | The( pro)renin receptor: a new addition to the renin- angiotensin system? |
| cord-275837-2avxd80i | MERS- CoV infection Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-002307-gk84fnb9 | -friend or foe? |
| cord-002307-gk84fnb9 | The brain renin- angiotensin system: a diversity of functions and implications for CNS diseases Brain renin angiotensin in disease Angiotensin-(1- 7): a novel peptide to treat hypertension and nephropathy in diabetes? |
| cord-266289-dkxhbmic | Will the real angiotensin converting enzyme please stand up? |
| cord-306755-9q1mawfs | The testicular transcript of the angiotensin I- converting enzyme encodes for the ancestral, non- duplicated form of the enzyme VanX, a bacterial D- alanyl- D- alanine dipeptidase: resistance, immunity, or survival function? |
| cord-304742-ytf2ilw4 | The SARS- CoV-2 receptor, ACE-2, is expressed on many different cell types: implications for ACE- inhibitor- and angiotensin II receptor blocker- based cardiovascular therapies ACE 2 coding variants: a potential X- linked risk factor for COVID-19 disease Host cell proteases: critical determinants of coronavirus tropism and pathogenesis Down syndrome and COVID-19: a perfect storm? |
| cord-024076-q9fw7ch1 | Be Withdrawn in the Current Setting of COVID-19 Infection? |
| cord-024076-q9fw7ch1 | Preventing a Covid-19 pandemic: ACE inhibitors as a potential risk factor for fatal Covid-19 Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-024076-q9fw7ch1 | should inhibitors of the renin- angiotensin system be withdrawn in patients with COVID-19? |
| cord-269151-r426u5dz | Angiotensin receptor blockers do not reduce risk of myocardial infarction, cardiovascular death, or total mortality: further evidence for the ARB- MI paradox Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial The Study on Cognition and Prognosis in the Elderly( SCOPE): principal results of a randomized double- blind intervention trial Effects of candesartan in patients with chronic heart failure and reduced left- ventricular systolic function intolerant to angiotensin- converting- enzyme inhibitors: the CHARMalternative trial Angiotensin- converting enzyme inhibitors or angiotensin receptor blockers in patients without heart failure? |
| cord-269151-r426u5dz | The question therefore being posed is, should ACE inhibitors ever be used to treat hypertension? |
| cord-269151-r426u5dz | key: cord-269151-r426u5dz authors: Turner, Jeffrey M.; Kodali, Ravi title: Should Angiotensin- Converting Enzyme Inhibitors ever Be Used for the Management of Hypertension? |
| cord-006082-x1kankxd | A decade of research: what have we learned? |
| cord-006082-x1kankxd | type 2 receptor agonist compound 21 reduces vascular injury and myocardial fibrosis in stroke- prone spontaneously hypertensive rats Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin- angiotensin system in myocardial infarction? |
| cord-253862-jl1zhg13 | Teicoplanin: an alternative drug for the treatment of COVID-19? |
| cord-253862-jl1zhg13 | what next? |
| cord-291146-f3e5ynhu | A pilot clinical trial of recombinant human angiotensin- converting enzyme 2 in acute respiratory distress syndrome Sars- CoV-2 and the black population ACE2 as shield or blade? |
| cord-306739-4lokd97u | Sind ACE- Hemmer eher negativ oder doch von Vorteil bei COVID-19? |
| cord-256020-wrui3i2l | The importance of recognising early possible ocular manifestation and using protective eyewear Can the Coronavirus Disease 2019( COVID-19) affect the eyes? |
| cord-256020-wrui3i2l | Worldometers( https://www. worldometers.info/coronavirus/?). |
| cord-286825-bu7j7kdr | An essential role in molting and morphogenesis of Caenorhabditis elegans for ACN-1, a novel member of the angiotensin- converting enzyme family that lacks a metallopeptidase active site Antimicrobial peptides in insects; structure and function Sequencing and characterisation of trypsin modulating oostatic factor( TMOF) from the ovaries of the grey fleshfly b- Amyloid catabolism: Roles for neprilysin( NEP) and other metallopeptidases? |
| cord-286825-bu7j7kdr | Prohormone Processing? |
| cord-319022-1twsxzcd | : What Is the Evidence? |
| cord-319022-1twsxzcd | The angiotensin II type 2 receptor: what is its clinical significance? |
| cord-267519-a0bcmjkn | : What Is the Evidence? |
| cord-267519-a0bcmjkn | At Present There Is No Evidence to Abandon Renin- Angiotensin System Blockers COVID-19 and the cardiovascular system Inhibitors of the Renin- Angiotensin- Aldosterone System and Covid-19 Switching antihypertensive therapy in times of COVID-19: why we should wait for the evidence SARS- CoV2: should inhibitors of the renin- angiotensin system be withdrawn in patients with COVID-19? |
| cord-267519-a0bcmjkn | Can angiotensin receptor- blocking drugs perhaps be harmful in the COVID-19 pandemic? |
| cord-267519-a0bcmjkn | Hypertension Localization of ACE2 in the renal vasculature: amplification by angiotensin II type 1 receptor blockade using telmisartan Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-286638-bqxyb61p | Hypertension Dipeptidyl peptidase-4 inhibitors can inhibit angiotensin converting enzyme COVID-19 and Diabetes: can DPP4 inhibition play a role? |
| cord-286638-bqxyb61p | Virtually perfect? |
| cord-286638-bqxyb61p | a retrospective propensity- matched cohort study Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-327697-80msva10 | After Myocardial Infarction by Blockade of Angiotensin II Receptors Effect of Angiotensin- Converting Enzyme Inhibition and Angiotensin II Receptor Blockers on Cardiac Angiotensin- Converting Enzyme 2 RAAS inhibitors do not increase the risk of COVID-19 Managing hypertension during the COVID-19 pandemic COVID19 and increased mortality in African Americans: socioeconomic differences or does the renin angiotensin system also contribute? |
| cord-327697-80msva10 | Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-351567-ifoe8x28 | Did pangolins spread the China coronavirus to people? |
| cord-289477-cjm7qhr4 | Carboxyalkanoyl and mercaptoalkanoyl amino acids Inhibition of angiotensin- coverting enzyme by analogs of peptides from Bothrops jararaca venom N- domain- specific substrate and C- domain inhibitors of angiotensin- converting enzyme: angiotensin-(1- 7) and keto- ACE Neprilysin inhibitors potentiate effects of bradykinin on b2 receptor Structural requirements for B 2-agonists with improved degradation stability Potentiation of kinin analogues by ramiprilat is exclusively related to their degradation A novel protein- protein interaction between a G protein- coupled receptor and the phosphatase SHP-2 is involved in bradykinin- induced inhibition of cell proliferation Kinins, receptors, kininases and inhibitors- where did they lead us? |
| cord-289477-cjm7qhr4 | Dopamine receptor modulation by a highly rigid spiro bicyclic peptidomimetic of Pro- Leu- Gly- NH 2 Studies on the angiotensinconverting enzyme and the kinin B2 receptor in the rabbit jugular vein: modulation of contractile response to bradykinin Combination of allyl protection and HYCRAM TMlinker technology for the synthesis of peptides with problematical amino acids and sequences Potentiation of the biological efficacy of bradykinin by ACE inhibitors: a shift in the affinity of the B2 receptor? |
| cord-289477-cjm7qhr4 | angiotensin- converting enzyme inhibitors directly stimulate the kinin B1 receptor? |
| cord-006087-hynkb0a8 | Angiotensin II suppression in humans by the orally active renin inhibitor aliskiren( SPP100): comparison with enalapril Vasopeptidase inhibition and angio- oedema β- amyloid catabolism: roles for neprilysin( NEP) and other metallopeptidases? |
| cord-006087-hynkb0a8 | Human performance: a role for the ACE genotype? |
| cord-006087-hynkb0a8 | Omapatrilat-the story of Overture and Octave Vasopeptidase inhibition: a double- edged sword? |
| cord-006087-hynkb0a8 | Randomized evaluation of strategies for left ventricular dysfunction( RESOLVD) pilot study Can angiotensin receptor antagonists be used safely in patients with previous ACE inhibitor- induced angioedema? |
| cord-353707-3n2nji8l | Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-353707-3n2nji8l | Can angiotensin receptor- blocking drugs perhaps be harmful in the COVID-19 pandemic? |
| cord-355807-q3bngari | : Where are we? |
| cord-346912-o09qmp7x | An SIR model with behavior Great Recession, great recovery? |
| cord-334490-42gykxdx | ( 3) Should I use anticoagulation in patients with COVID-19? |
| cord-334490-42gykxdx | How long can invasive procedures for cardiac conditions be postponed? |
| cord-334490-42gykxdx | What now? |
| cord-015859-5kt59ose | ACE inhibitors correlates with ACE C- and N- domain blockade ACE- versus chymase- dependent angiotensin II generation in human coronary arteries: a matter of efficiency? |
| cord-015859-5kt59ose | Evidence for a C- terminal transmembrane anchor and for a proteolytic processing of the secreted recombinant and plasma enzymes Differential distribution of angiotensin AT2 receptors in the normal and failing human heart Angiotensin AT2 receptors: cardiovascular hope or hype? |
| cord-015859-5kt59ose | I Angiotensin converting enzyme is the main contributor to angiotensin I- II conversion in the interstitium of the isolated perfused rat heart Angiotensin receptors: a new role in cancer? |
| cord-015859-5kt59ose | receptor- mediated vasodilation in the heart: effect of myocardial infarction Cardiac angiotensin II: an intracrine hormone? |
| cord-015859-5kt59ose | which angiotensin receptor is the culprit in cardiac hypertrophy? |
| cord-315754-dq2empne | : Revision of screening strategies urgently needed Teicoplanin: An alternative drug for the treatment of coronavirus COVID-19? |
| cord-315754-dq2empne | A key target for antivirals Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-315754-dq2empne | COVID-19: What is next for public health? |
| cord-315754-dq2empne | Critical determinants of coronavirus tropism and pathogenesis Promising approaches for the treatment and prevention of viral respiratory illnesses The SARS, MERS and novel coronavirus( COVID-19) epidemics, the newest and biggest global health threats: What lessons have we learned? |
| cord-290148-6cxndab8 | Are there similarities between ACE-1, the target of ACEIs, and ACE-2, the target of SARS- CoV and SARS- CoV-2? |
| cord-290148-6cxndab8 | EMA Advises Continued Use of Medicines for Hypertension, Heart or Kidney Disease During COVID-19 Pandemic: EMA Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-290148-6cxndab8 | Enalapril attenuates downregulation of angiotensin- converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat Should COVID-19 concern nephrologists? |
| cord-290148-6cxndab8 | What is the role of ACE-1 and ACE-2 in infections caused by SARS- CoV and SARS- CoV-2? |
| cord-290148-6cxndab8 | why and to what extent? |
| cord-332680-zfn81hew | Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-332680-zfn81hew | Can angiotensin receptor- blocking drugs perhaps be harmful in the COVID-19 pandemic? |
| cord-332680-zfn81hew | Diabetes, Obes Metabolism Characteristics and outcomes of 21 critically ill patients with COVID-19 in Washington state Antihypertensive drugs and risk of COVID-19? ACEI/ ARB use and risk of infection or severity or mortality of COVID-19: a systematic review and meta- analysis Use of GRADE for assessment of evidence about prognosis: rating confidence in estimates of event rates in broad categories of patients Angiotensin- converting enzyme 2 protects from severe acute lung failure Renin- angiotensin- aldosterone system inhibitors in patients with COVID-19 Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury Discontinuation of and changes in drug therapy for hypertension among newly- treated patients: a population- based study in Italy |
| cord-352230-8mazd3eu | IIB inhibits antibody- dependent enhancement of dengue virus infection Immunomodulation by IVIg and the role of Fc- gamma receptors: classic mechanisms of action after all? |
| cord-352230-8mazd3eu | Is the anti- psychotic, 10-(3-(dimethylamino) propyl) phenothiazine( promazine), a potential drug with which to treat SARS infections? |
| cord-326405-3446eyi3 | Enhanced renal immunocytochemical expression of ANG-(1- 7) and ACE2 during pregnancy Renal ACE2 expression in human kidney disease? |
| cord-326405-3446eyi3 | This was the first demonstration that genetic Ace2 deficiency in diabetes is associated with ANG IIx- mediated acceleration of glomerular injury Angiotensinconverting enzyme 2 is an essential regulator of heart function Developmental expression of ACE2 in the SHR kidney: a role in hypertension? |
| cord-326405-3446eyi3 | What may be the significance of reduced ACE2 and increased ACE at the glomerular level? |
| cord-326405-3446eyi3 | a renoprotective combination? |
| cord-289144-d6fgs8qg | COVID-19: what do we need to know about ICU delirium during the SARS- CoV-2 pandemic? |
| cord-289144-d6fgs8qg | Why does ACE genotyping not predict the therapeutic efficacy of ACE inhibition? |
| cord-289144-d6fgs8qg | depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor COVID and the renin- angiotensin system: are hypertension or its treatments deleterious? |
| cord-289144-d6fgs8qg | inhibitors/ angiotensin receptor blockers have a biphasic effect? |
| cord-289144-d6fgs8qg | rting Enzyme 2)-independent Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-330093-asba80bi | ACE-2 expression in the small airway epithelia of smokers and COPD patients: implications for COVID-19 COVID-19 and smoking: is nicotine the hidden link? |
| cord-330093-asba80bi | COVID-19 and nicotine as a mediator of ACE-2 Systematic review of the prevalence of current smoking among hospitalized COVID-19 patients in China: could nicotine be a therapeutic option? |
| cord-330093-asba80bi | COVID-19 and vaping: risk for increased susceptibility to SARS- CoV-2 infection? |
| cord-330093-asba80bi | statista.com/statistics/673619/smoking-prevalence-among-men-us-by-age/ Date last accessed COVID-19 and smoking: is nicotine the hidden link? |
| cord-326820-11sl17ap | Does angiotensin- converting enzyme gene polymorphism affect blood pressure? |
| cord-326820-11sl17ap | Findings after 6 years of follow- up in healthy subjects Is the influence of variation in the ACE gene on the prospective risk of Type 2 diabetes in middle- aged men modified by obesity? |
| cord-326820-11sl17ap | key: cord-326820- 11sl17ap authors: Bousquet, Jean; Anto, Josep M.; Iaccarino, Guido; Czarlewski, Wienczyslawa; Haahtela, Tari; Anto, Aram; Akdis, Cezmi A.; Blain, Hubert; Canonica, G. Walter; Cardona, Victoria; Cruz, Alvaro A.; Illario, Maddalena; Ivancevich, Juan Carlos; Jutel, Marek; Klimek, Ludger; Kuna, Piotr; Laune, Daniel; Larenas- Linnemann, Désirée; Mullol, Joaquim; Papadopoulos, Nikos G.; Pfaar, Oliver; Samolinski, Boleslaw; Valiulis, Arunas; Yorgancioglu, Arzu; Zuberbier, Torsten title: Is diet partly responsible for differences in COVID-19 death rates between and within countries? |
| cord-311099-59pnm4fn | ACE inhibition Gradual reactivation of vascular angiotensin I to angiotensin II conversion during chronic ACE inhibitor therapy in patients with diabetes mellitus Determinants of increased angiotensin II levels in severe chronic heart failure patients despite ACE inhibition How often are angiotensin II and aldosterone concentrations raised during chronic ACE inhibitor treatment in cardiac failure? |
| cord-311099-59pnm4fn | Bradykinin, angiotensin-(1- 7), and ACE inhibitors: how do they interact? |
| cord-311099-59pnm4fn | Liver fibrosis: a balance of ACEs? |
| cord-018009-8j40876m | ( PREAMI) Study A new hormone of the angiotensin system Long- term ACE- inhibitor therapy in patients with heart failure or left- ventricular dysfunction: a systematic overview of data from individual patients Signaling by the angiotensin- converting enzyme Direct myocardial and coronary effects of enalaprilat in patients with dilated cardiomyopathy: assessment by a bilateral intracoronary infusion technique Should angiotensin- converting enzyme- inhibitors be used to improve outcome in patients with coronary artery disease and'preserved'left ventricular function? |
| cord-018009-8j40876m | Angiotensin- converting enzyme inhibitors potentiate preconditioning through bradykinin B 2 receptor activation in human heart Are ACE inhibitors a"magic bullet"against oxidative stress? |
| cord-018009-8j40876m | Does the renin- angiotensin system exert an important stimulatory influence on the sympathetic nervous system? |
| cord-018009-8j40876m | Results of the survival and ventricular enlargement trial Effect of captopril on progressive ventricular dilatation after anterior myocardial infarction Valsartan, captopril, or both in myocardial infarction complicated by heart failure, left ventricular dysfunction, or both Survival after an experimental myocardial infarction: beneficial effects of long- term therapy with captopril ACE inhibitors for patients with vascular disease without left ventricular dysfunction- may they rest in PEACE? |
| cord-018009-8j40876m | The cardiac renin- angiotensin system: conceptual, or a regulator of cardiac function? |
| cord-018009-8j40876m | prevent restenosis after percutaneous transluminal coronary angioplasty? |
| cord-318327-9sh2eksm | Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin- angiotensin system in myocardial infarction? |
| cord-318327-9sh2eksm | Do inhibitors of angiotensin- Iconverting enzyme protect against risk of cancer? |
| cord-318327-9sh2eksm | Quantitative analysis by the polymerase chain reaction Angiotensin and cell growth: a link to cardiovascular hypertrophy? |
| cord-318327-9sh2eksm | myocardial ischemia/ reperfusion Angiotensin-(1- 7) inhibits growth of cardiac myocytes through activation of the mas receptor Emerging evidence for a functional angiotensin- converting enzyme 2-angiotensin-(1- 7)-MAS receptor axis: more than regulation of blood pressure? |
| cord-346811-gorp9n1g | -United States Low incidence of daily active tobacco smoking in patients with symptomatic COVID-19 Nicotine treatment for ulcerative colitis Is smoking beneficial for granulomatous lung diseases? |
| cord-346811-gorp9n1g | How might this impact on clinical practice? |
| cord-346811-gorp9n1g | What is already known on this subject? |
| cord-346811-gorp9n1g | What might this study add? |
| cord-295041-5vpawtef | ( SARS- CoV-2) Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host- virus interaction, and proposed neurotropic mechanisms Can the enteric nervous system be an alternative entrance door in SARS- CoV2 neuroinvasion? |
| cord-295041-5vpawtef | A mechanism of virus- induced demyelination Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system? |
| cord-295041-5vpawtef | COVID-19 in a MS patient treated with ocrelizumab: does immunosuppression have a protective role? |
| cord-295041-5vpawtef | How Covid-19 can damage the brain Neurological manifestations in severe acute respiratory syndrome Guillain- Barré syndrome associated with SARS- CoV-2 infection: causality or coincidence? |
| cord-295041-5vpawtef | More Prevalent Than Acknowledged? |
| cord-295041-5vpawtef | causative or coincidental? |
| cord-266755-y2lf7ssp | 2 infection SARS- CoV-2: ACE inhibitors, disastrous or desirable? |
| cord-266755-y2lf7ssp | A H5N1 infections Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-266755-y2lf7ssp | Might renin- angiotensin system blockers play a role in the COVID-19 pandemic? |
| cord-266755-y2lf7ssp | Record- linkage study in Italy Structure analysis of the receptor binding of 2019-nCoV Soluble angiotensin- converting enzyme 2: a potential approach for coronavirus infection therapy? |
| cord-266755-y2lf7ssp | The epidemiology and pathogenesis of coronavirus disease( COVID-19) outbreak Structure, function, and antigenicity of the SARS- CoV-2 spike glycoprotein Pathogenesis of severe acute respiratory syndrome Should Covid-19 concern nephrologists? |
| cord-266755-y2lf7ssp | Why and to what extent? |
| cord-266755-y2lf7ssp | a single- centered, retrospective, observational study Clinical characteristics of 2019 novel coronavirus infection in China Is drug choice by general practitioners influenced by exposure to specialists? |
| cord-338417-7kw9lws0 | Antihypertensive drugs and risk of COVID-19? |
| cord-338417-7kw9lws0 | Antihypertensive drugs and risk of COVID-19? |
| cord-338417-7kw9lws0 | Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-338417-7kw9lws0 | JAMA Antihypertensive drugs and risk of COVID-19? |
| cord-338417-7kw9lws0 | Time to use the p- word? |
| cord-338417-7kw9lws0 | What is the evidence? |
| cord-338417-7kw9lws0 | Why and to what extent? |
| cord-338417-7kw9lws0 | mBio Should COVID-19 concern nephrologists? |
| cord-342786-dl8vjwfn | COVID-19 in the heart and the lungs: could we"Notch"the inflammatory storm? |
| cord-342786-dl8vjwfn | Can we use interleukin-6( IL-6) blockade for coronavirus disease 2019( COVID-19)-induced cytokine release syndrome( CRS)? |
| cord-342786-dl8vjwfn | Cardiovascular manifestations and treatment considerations in covid-19 Cardiac Involvement in a Patient With Coronavirus Disease 2019( COVID-19) Cardiac Valves: Another"Disaster- Hit Area"of COVID-19 Patients? |
| cord-342786-dl8vjwfn | The Myocarditis Treatment Trial Investigators The Imperfect Cytokine Storm: Severe COVID-19 with ARDS in Patient on Durable LVAD Support Corticosteroids for viral myocarditis Controlled Trial of Intravenous Immune Globulin in Recent- Onset Dilated Cardiomyopathy Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma Statin therapy in COVID-19 infection COVID-19, hypertension and cardiovascular diseases: Should we change the therapy? |
| cord-342786-dl8vjwfn | The possible mechanisms of action of 4-aminoquinolines( chloroquine/ hydroxychloroquine) against Sars- Cov-2 infection( COVID-19): A role for iron homeostasis? |
| cord-322966-o65fo853 | Circulating ACE-2 activity correlated with cardiovascular disease development Reninangiotensin- aldosterone system inhibitors in patients with COVID-19 COVID-19 and angiotensin- converting enzyme inhibitors and angiotensin receptor blockers: what is the evidence? |
| cord-322966-o65fo853 | Could these drugs – which include angiotensin converting enzyme inhibitors( ACEIs) and angiotensin receptors blockers( ARBs) – be harmful or potential key therapeutic agents in COVID-19? |
| cord-322966-o65fo853 | Could these drugs-which include angiotensin converting enzyme inhibitors( ACEIs) and angiotensin receptors blockers( ARBs)-be harmful or potential key therapeutic agents in COVID- 19? |
| cord-322966-o65fo853 | Implications for lipid metabolism remodelling upon coronavirus replication Lysophosphatidylinositol signalling and metabolic diseases Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post- SARS syndrome; a case- controlled study Altered lipid metabolism in recovered SARS patients twelve years after infection Long term bone and lung consequences associated with hospital-acquired severe acute respiratory syndrome: a 15 year follow- up from a prospective cohort study Autoantibodies against human epithelial cells and endothelial cells after severe acute respiratory syndrome( SARS)-associated coronavirus infection Are vitamin D receptor agonists like angiotensin- converting enzyme inhibitors without side effects? |
| cord-322966-o65fo853 | Why do 81% of cases have a mild disease and yet 19% have a more severe disease? |
| cord-322966-o65fo853 | do angiotensin- converting enzyme inhibitors/ angiotensin receptor blockers have a biphasic effect? |
| cord-322966-o65fo853 | key: cord-322966-o65fo853 authors: Arnold, Ruth H. title: COVID-19 – Does This Disease Kill Due to Imbalance of the Renin Angiotensin System( RAS) Caused by Genetic and Gender Differences in the Response to Viral ACE 2 Attacks? date: 2020- 05- 25 journal: Heart Lung Circ DOI: 10.1016/ |
| cord-264828-6w13xo2a | Are such effects dangerous, neutral or even useful in older, COVID-19-affected patients? |
| cord-264828-6w13xo2a | Are these two drug classes( ARBs, ACE- Is or other antihypertensive drugs) acting differently from each other in the pathogenetic evolution of SARS- CoV-2 infection? |
| cord-264828-6w13xo2a | COVID-19 pneumonia: a random association? |
| cord-264828-6w13xo2a | Could ACE- Is or ARBs eventually be resulting in neutral, useful, or even dangerous in terms of cardiovascular protection in the clinical course of SARS- CoV-2 frail, comorbid infected patients? |
| cord-264828-6w13xo2a | Do ACE- Is and ARBs display similar or quantitatively divergent effects in COVID-19 patients? |
| cord-264828-6w13xo2a | Do they act on multiple cell types? |
| cord-264828-6w13xo2a | Do they affect infection of different cell types? |
| cord-264828-6w13xo2a | How they affect infection of the numerous different type of ACE2 positive cells in the organism throughout the human body? |
| cord-264828-6w13xo2a | Vascular angiotensinconverting enzyme 2: lord of the ring? |
| cord-264828-6w13xo2a | We claim the need of adequately powered, prospective studies aimed at answering the following questions of paramount importance for cardiovascular, internal and emergency medicine: Do ACE- Is and ARBs exert similar or different effects on infection or disease course? |
| cord-264828-6w13xo2a | up- regulates angiotensin I- converting enzyme( ACE), but down- regulates ACE2 via the AT1-ERK/ p38 MAP kinase pathway Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-317878-bqpj0ey0 | Do men have a higher case fatality rate of severe acute respiratory syndrome than women do? |
| cord-317878-bqpj0ey0 | From kinetics to dynamics: are there differences between ACE inhibitors? |
| cord-317878-bqpj0ey0 | Implications to myocardial ischemia Interaction between angiotensin type 1, type 2, and Mas receptors to regulate adult neurogenesis in the brain ventricular- subventricular zone Expression of renin- angiotensin system components in the taste organ of mice COVID-19 does not lead to a"typical"acute respiratory distress syndrome Acute respiratory distress syndrome Acute respiratory distress syndrome: an update and review COVID-19 pneumonia: ARDS or not? |
| cord-317878-bqpj0ey0 | Intrarenal renin- angiotensin system: locally synthesized or taken up via endocytosis? |
| cord-317878-bqpj0ey0 | The coming of age of the angiotensin hypothesis in Alzheimer's disease: progress toward disease prevention and treatment? |
| cord-317878-bqpj0ey0 | When? |
| cord-317878-bqpj0ey0 | Which one to give? |
| cord-317878-bqpj0ey0 | Why a fast blood glucose control should be mandatory Hypertension in the African American population: a succinct look at its epidemiology, pathogenesis, and therapy Office of minority health obesity and African Americans Differences in hypertension between blacks and whites: an overview Angiotensinogen and blood pressure among blacks: findings from a community survey in Jamaica African Americans, hypertension and the renin angiotensin system Is hypertension in African- descent populations contributed to by an imbalance in the activities of the ACE2/ Ang-(1- 7)/Mas and the ACE/ Ang II/ AT 1 axes? |
| cord-317878-bqpj0ey0 | Why? |
| cord-317878-bqpj0ey0 | inhibitors of the renin- angiotensin system be withdrawn in patients with COVID-19? |
| cord-317878-bqpj0ey0 | inhibitors/ angiotensin receptor blockers have a biphasic effect? |
| cord-317878-bqpj0ey0 | patients so severely hypoxemic in the first place? |
| cord-269776-hj1s3ipp | And today? |
| cord-269776-hj1s3ipp | Bradykinin- mediated angioedema? |
| cord-269776-hj1s3ipp | Does variation in fetal production of kinin- inactivators or other factors underlie any variation in angioedema symptoms between pregnancies in the same individual, or between individuals in the same families, all with the same C1-INH mutation? |
| cord-269776-hj1s3ipp | For example, are there hormonal factors in pregnancy, not operative during estrogen therapy, that increase kinin inactivation or other factors and reduce angioedema, despite an estrogeninduced lowering of C1-INH? |
| cord-269776-hj1s3ipp | How, chemically, does one proceed from insufficient functional C1-INH to localized, full- blown angioedema? |
| cord-269776-hj1s3ipp | Is the fetus or placenta a source of kinin inactivation factors or other factors that mitigate the effects of estrogen- induced lowering of C1-INH? |
| cord-269776-hj1s3ipp | Lupus erythematosus associated with C1 inhibitor deficiency C1 inhibitor deficiency in a patient with rheumatoid arthritis- increased risk of adverse effects of penicillamine? |
| cord-269776-hj1s3ipp | Neuroendocrine connection? |
| cord-269776-hj1s3ipp | What is different about the small percentage of patients taking ACE inhibitors who have angioedema? |
| cord-269776-hj1s3ipp | What regulatory pathways are involved? |
| cord-269776-hj1s3ipp | Why should patients with ACE inhibitorinduced angioedema have this angioedema in bouts if bradykinin is constantly elevated? |
| cord-269776-hj1s3ipp | antihypertensive therapy Vasopeptidase inhibition: a double- edged sword? |
| cord-269776-hj1s3ipp | replacement therapy with C1-INH and analysis of patients'C1-INH and anti- C1-INH autoantibodies Autoimmune C1-inhibitor deficiency Acquired angioedema with C1 inhibitor deficiency: is the distinction between type I and type II still relevant? |
| cord-349445-yh6ndtgm | : What Is the Evidence? |
| cord-349445-yh6ndtgm | Are certain drugs associated with enhanced mortality in COVID-19? |
| cord-349445-yh6ndtgm | COVID-19: Epidemiology, Evolution, and Cross- Disciplinary Perspectives COVID-19 and the Renin- Angiotensin System SARS- CoV2: should inhibitors of the renin- angiotensin system be withdrawn in patients with COVID-19? |
| cord-349445-yh6ndtgm | Close to a Cure? |
| cord-349445-yh6ndtgm | Covid-19 Can angiotensin receptor- blocking drugs perhaps be harmful in the COVID-19 pandemic? |
| cord-349445-yh6ndtgm | Evidence- Based Med New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? |
| cord-349445-yh6ndtgm | Hence, the question now, may the reviewed actions of NEP pathways be sufficient to impose a new effective strategy for COVID-19 management as compared to the suggested repurposed drugs? |
| cord-349445-yh6ndtgm | Modulators of inflammation in acute lung injury? |
| cord-349445-yh6ndtgm | Neprilysin inhibition: a new therapeutic option for type 2 diabetes? |
| cord-349445-yh6ndtgm | Role in reducing β- amyloid levels Estrogen regulation of the neprilysin gene through a hormone- responsive element Influence of Selected Natural Products on Neutral Endopeptidase Activity and β- Amyloid Production in SK- N- SH Cells Possible role of Resveratrol targeting Estradiol and Neprilysin pathways in Lipopolysaccharide model of Alzheimer disease Epigallocatechin-3-gallate attenuates cognitive deterioration in Alzheimer's disease model mice by upregulating neprilysin expression Effects of Naoerkang on expressions of β- amyloid peptide 1- 42 and neprilysin in hippocampus in a rat model of Alzheimer's disease Decoding the enigma of antiviral crisis: Does one target molecule regulate all? |
| cord-349445-yh6ndtgm | So Far, Pathogens Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study COVID-19: consider cytokine storm syndromes and immunosuppression Correspondence Use of antiviral drugs to reduce COVID-19 Therapeutic options for the 2019 novel coronavirus( 2019-nCoV) Drug treatment options for the 2019-new coronavirus( 2019-nCoV) Molecular immune pathogenesis and diagnosis of COVID-19 Cytokinstormer ved covid-19? |
| cord-349445-yh6ndtgm | v2, ArXiv Prepr Acute respiratory distress syndrome leads to reduced ratio of ACE/ ACE2 activities and is prevented by angiotensin-(1- 7) or an angiotensin II receptor antagonist The Angiotensin- Converting Enzyme 2/ Angiogenesis-(1- 7)/Mas Axis Confers Cardiopulmonary Protection against Lung Fibrosis and Pulmonary Hypertension Decreased levels of serum Angiotensin-(1- 7) in patients with pulmonary arterial hypertension due to congenital heart disease Reninangiotensin- system, a potential pharmacological candidate, in acute respiratory distress syndrome during mechanical ventilation Dose- dependent, therapeutic potential of angiotensin-(1- 7) for the treatment of pulmonary arterial hypertension Angiotensin II type 2 receptor( AT2R) in renal and cardiovascular disease Angiotensin-(1- 7): A Novel Peptide to Treat Hypertension and Nephropathy in Diabetes? |