This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.
trigram | frequency |
---|---|
of ang ii | 478 |
in patients with | 324 |
angiotensin converting enzyme | 247 |
of the renin | 202 |
as well as | 199 |
of ace in | 186 |
of the ras | 181 |
the development of | 176 |
of angiotensin ii | 158 |
of the ace | 149 |
the role of | 146 |
ang ii and | 145 |
angiotensin ii type | 141 |
the expression of | 138 |
acute respiratory syndrome | 132 |
the effects of | 130 |
the presence of | 126 |
activation of the | 121 |
the at receptor | 121 |
severe acute respiratory | 120 |
ii type receptor | 118 |
is associated with | 111 |
in the brain | 110 |
ace and ace | 106 |
in the heart | 106 |
the treatment of | 106 |
of ace and | 105 |
been shown to | 104 |
expression of ace | 103 |
the use of | 103 |
angiotensin ii receptor | 102 |
role of the | 100 |
role in the | 98 |
to ang ii | 98 |
ang ii levels | 95 |
the pathogenesis of | 94 |
in addition to | 91 |
in order to | 91 |
the ace ang | 90 |
the effect of | 90 |
respiratory distress syndrome | 89 |
it has been | 87 |
acute respiratory distress | 87 |
ang ii to | 86 |
and ang ii | 85 |
converting enzyme in | 85 |
in the kidney | 85 |
effects of ang | 85 |
ace in the | 83 |
ang ii in | 83 |
patients with covid | 82 |
the synthesis of | 82 |
the regulation of | 82 |
levels of ang | 81 |
due to the | 80 |
of angiotensin converting | 80 |
involved in the | 78 |
smooth muscle cells | 78 |
acute lung injury | 77 |
the formation of | 77 |
one of the | 76 |
the ang ii | 76 |
the production of | 76 |
components of the | 75 |
respiratory syndrome coronavirus | 75 |
of the angiotensin | 74 |
has been shown | 73 |
angiotensin system in | 73 |
by ang ii | 73 |
the mas receptor | 73 |
the activation of | 73 |
an increase in | 71 |
of ang i | 70 |
actions of ang | 68 |
an important role | 66 |
role of ace | 66 |
converting enzyme inhibition | 65 |
effect of angiotensin | 65 |
in response to | 65 |
in the pathogenesis | 64 |
ang ii at | 64 |
of ace inhibitors | 63 |
was associated with | 63 |
ace expression in | 62 |
a role in | 62 |
role of angiotensin | 62 |
and angiotensin ii | 61 |
that ang ii | 61 |
converting enzyme inhibitors | 60 |
in ang ii | 59 |
ii in the | 59 |
a variety of | 59 |
have shown that | 58 |
effects of the | 58 |
of the raas | 58 |
in heart failure | 57 |
spontaneously hypertensive rats | 57 |
the progression of | 57 |
on the other | 56 |
of at r | 56 |
in the rat | 56 |
the at r | 56 |
blood pressure and | 56 |
expression in the | 55 |
in the treatment | 54 |
in the regulation | 54 |
of patients with | 54 |
based on the | 54 |
ang i and | 53 |
the angiotensin ii | 53 |
ii to ang | 53 |
induced lung injury | 53 |
functional receptor for | 53 |
formation of ang | 53 |
for the treatment | 53 |
converting enzyme and | 52 |
in the lung | 52 |
vascular smooth muscle | 52 |
renin angiotensin system | 52 |
ang i to | 51 |
of the at | 51 |
effects of ace | 51 |
of the peptide | 51 |
the other hand | 51 |
the discovery of | 51 |
the present study | 51 |
conversion of ang | 51 |
angiotensin ii in | 50 |
in the presence | 50 |
converting enzyme is | 50 |
in this study | 50 |
of the ang | 50 |
ang ii is | 50 |
from ang ii | 50 |
apelin ko mice | 49 |
levels of ace | 49 |
ii at r | 49 |
the actions of | 49 |
important role in | 49 |
the activity of | 49 |
ace and ang | 48 |
the release of | 48 |
shown to be | 48 |
the levels of | 47 |
the importance of | 47 |
after myocardial infarction | 47 |
of blood pressure | 47 |
in the lungs | 47 |
a crucial role | 47 |
blood pressure in | 47 |
expressed in the | 46 |
structure of the | 46 |
in blood pressure | 46 |
ace is a | 45 |
ace ang ii | 45 |
i to ang | 45 |
central nervous system | 45 |
ace inhibitors and | 44 |
angiotensin i to | 44 |
chronic kidney disease | 44 |
angiotensin receptor blockers | 44 |
is involved in | 44 |
found to be | 44 |
of heart failure | 44 |
with ang ii | 44 |
in the human | 44 |
i to angiotensin | 44 |
a number of | 43 |
the ace gene | 43 |
in the development | 43 |
contribute to the | 43 |
expression of the | 43 |
as a result | 43 |
the existence of | 42 |
tumor necrosis factor | 42 |
at and at | 42 |
receptor for sars | 42 |
beneficial effects of | 41 |
in animal models | 41 |
has been reported | 41 |
patients with hypertension | 41 |
the conversion of | 40 |
production of ang | 40 |
in vitro and | 40 |
in the present | 40 |
the renin angiotensin | 40 |
of ace inhibition | 40 |
effects of angiotensin | 40 |
receptor for the | 40 |
the action of | 39 |
a novel angiotensin | 39 |
be involved in | 39 |
and at r | 39 |
ace inhibitor therapy | 39 |
loss of ace | 39 |
a role for | 38 |
at r and | 38 |
activity of the | 38 |
ang ii by | 38 |
a series of | 38 |
at r axis | 38 |
reactive oxygen species | 38 |
was shown to | 37 |
of angiotensin i | 37 |
associated with the | 37 |
the generation of | 37 |
blockade of the | 37 |
actions of angiotensin | 37 |
we found that | 37 |
studies have shown | 36 |
from ang i | 36 |
of angiotensin peptides | 36 |
concentrations of ang | 36 |
a reduction in | 35 |
are associated with | 35 |
contributes to the | 35 |
mas receptor axis | 35 |
to be a | 35 |
the absence of | 35 |
related to the | 35 |
the active site | 35 |
plasma levels of | 35 |
the central nervous | 35 |
angiotensin ii and | 35 |
angiotensin type receptor | 35 |
i and ang | 35 |
responsible for the | 34 |
the pathophysiology of | 34 |
ace activity in | 34 |
axis of the | 34 |
the cardiovascular system | 34 |
is expressed in | 34 |
converting enzyme activity | 34 |
analysis of the | 34 |
converting enzyme gene | 34 |
heart failure and | 34 |
has been found | 34 |
part of the | 34 |
an ace inhibitor | 34 |
and in vivo | 34 |
distribution of ace | 33 |
associated with increased | 33 |
with heart failure | 33 |
of ace is | 33 |
in endothelial cells | 33 |
well as the | 33 |
and blood pressure | 33 |
was found to | 33 |
the increase in | 33 |
converts angiotensin i | 33 |
the level of | 33 |
according to the | 32 |
of the sars | 32 |
angiotensin system and | 32 |
inhibition of the | 32 |
converting enzyme inhibitor | 32 |
such as the | 32 |
clinical characteristics of | 32 |
downregulation of ace | 32 |
a result of | 32 |
ii and ang | 32 |
enzyme in the | 32 |
and at receptors | 32 |
a systematic review | 32 |
the g protein | 32 |
have been identified | 32 |
of the n | 32 |
ang ii infusion | 32 |
and activation of | 31 |
is an essential | 31 |
also known as | 31 |
be associated with | 31 |
vitro and in | 31 |
there is a | 31 |
to be the | 31 |
in spontaneously hypertensive | 31 |
in contrast to | 31 |
and ace in | 31 |
inhibitors and angiotensin | 31 |
has also been | 31 |
may contribute to | 31 |
regulation of the | 31 |
addition to the | 31 |
has not been | 30 |
associated with a | 30 |
understanding of the | 30 |
for ang ii | 30 |
a decrease in | 30 |
transforming growth factor | 30 |
endothelial growth factor | 30 |
coupled receptor mas | 30 |
some of the | 30 |
at receptors in | 30 |
the loss of | 30 |
vascular endothelial growth | 30 |
increased ang ii | 30 |
acute lung failure | 30 |
of ace protein | 30 |
the ras in | 30 |
activity in the | 29 |
changes in the | 29 |
that ace is | 29 |
peptides by human | 29 |
in rats with | 29 |
receptors in the | 29 |
ace and the | 29 |
and heart failure | 29 |
of the mas | 29 |
human homolog of | 29 |
cells in the | 29 |
ang ii receptor | 29 |
is an endogenous | 29 |
compared with the | 29 |
the nlrp inflammasome | 29 |
increased levels of | 29 |
expression of angiotensin | 29 |
a functional receptor | 29 |
mouse model of | 29 |
effect of ace | 28 |
levels in the | 28 |
hydrolysis of biological | 28 |
ace activity and | 28 |
of cardiac hypertrophy | 28 |
been reported to | 28 |
biological peptides by | 28 |
cardiovascular and renal | 28 |
of the two | 28 |
congestive heart failure | 28 |
showed that the | 28 |
the brain ras | 28 |
the spike protein | 28 |
the involvement of | 28 |
the degradation of | 28 |
in the central | 28 |
li et al | 28 |
for the sars | 28 |
converting enzyme protects | 28 |
severe acute lung | 28 |
of the enzyme | 28 |
effect of the | 28 |
a human homolog | 28 |
increase in ang | 28 |
of heart function | 28 |
of biological peptides | 28 |
plays an important | 28 |
the severity of | 27 |
cloning and functional | 27 |
functional expression as | 27 |
leading to the | 27 |
patients with heart | 27 |
enzyme protects from | 27 |
the fact that | 27 |
was used to | 27 |
system in the | 27 |
patients with severe | 27 |
in the ace | 27 |
in women with | 27 |
and ace activity | 27 |
ras in the | 27 |
ii receptor blockers | 27 |
to determine the | 27 |
expression as a | 27 |
cells of the | 27 |
and functional expression | 27 |
the risk of | 27 |
crucial role of | 27 |
binding to the | 27 |
in angiotensin ii | 27 |
in which the | 27 |
by angiotensin ii | 27 |
cardiac hypertrophy and | 27 |
compared to the | 27 |
have been shown | 27 |
of at receptors | 26 |
an essential regulator | 26 |
the ang tie | 26 |
and in the | 26 |
high levels of | 26 |
in combination with | 26 |
may lead to | 26 |
the inhibition of | 26 |
ang tie system | 26 |
evidence for a | 26 |
regulator of the | 26 |
this article is | 26 |
essential regulator of | 26 |
amino acid residues | 26 |
activity of ace | 26 |
increased expression of | 26 |
regulator of heart | 26 |
of the brain | 26 |
recombinant human ace | 26 |
of the disease | 26 |
of the classical | 26 |
effect of ang | 26 |
the aim of | 26 |
role of ang | 26 |
ligand for the | 26 |
the gastrointestinal tract | 25 |
in a rat | 25 |
animal models of | 25 |
a rat model | 25 |
have been reported | 25 |
to evaluate the | 25 |
found in the | 25 |
review and meta | 25 |
which can be | 25 |
the sars coronavirus | 25 |
chronic heart failure | 25 |
at r in | 25 |
play a role | 25 |
the surface of | 25 |
enzyme inhibitors and | 25 |
blood pressure regulation | 25 |
the cell surface | 25 |
effect on the | 25 |
nitric oxide synthase | 25 |
induced cardiac hypertrophy | 25 |
of diabetic nephropathy | 25 |
and at receptor | 25 |
from severe acute | 25 |
systematic review and | 25 |
angiotensin ii receptors | 25 |
is a functional | 25 |
in the ras | 25 |
a mouse model | 25 |
stimulation of the | 25 |
the ratio of | 25 |
of the human | 25 |
by human angiotensin | 25 |
and angiotensin receptor | 25 |
ang ii type | 25 |
is known to | 25 |
generation of ang | 25 |
of cyp b | 25 |
found that the | 25 |
homolog of angiotensin | 25 |
the ability of | 24 |
morbidity and mortality | 24 |
the reninangiotensin system | 24 |
have demonstrated that | 24 |
at room temperature | 24 |
deletion of the | 24 |
of ace expression | 24 |
is mediated by | 24 |
in the absence | 24 |
in cardiovascular disease | 24 |
in sars coronavirus | 24 |
enzyme and angiotensin | 24 |
due to its | 24 |
first step in | 24 |
for sars coronavirus | 24 |
of amino acids | 24 |
the balance between | 24 |
as shown in | 24 |
ace knockout mice | 24 |
and treatment of | 24 |
inflammation and fibrosis | 24 |
ang ii or | 24 |
the ras is | 24 |
differences in the | 24 |
pulmonary arterial hypertension | 24 |
the structure of | 24 |
of severe acute | 24 |
of a novel | 24 |
the cytokine storm | 24 |
sodium and water | 24 |
in the cardiovascular | 24 |
angiotensin ii at | 24 |
observed in the | 23 |
patients with chronic | 23 |
tissue distribution of | 23 |
ace as a | 23 |
enzyme is a | 23 |
an angiotensin ii | 23 |
the functional receptor | 23 |
is one of | 23 |
it is not | 23 |
the heart and | 23 |
highly expressed in | 23 |
santos et al | 23 |
a recent study | 23 |
of the reninangiotensin | 23 |
there is no | 23 |
on blood pressure | 23 |
most of the | 23 |
increase in the | 23 |
ace is also | 23 |
coronary artery disease | 23 |
an endogenous ligand | 23 |
treatment of covid | 23 |
with coronavirus disease | 23 |
enzyme is an | 23 |
acts as a | 23 |
the beneficial effects | 23 |
protects from severe | 23 |
the control of | 23 |
to the development | 23 |
the function of | 23 |
conflict of interest | 23 |
the design of | 23 |
all rights reserved | 23 |
of the kidney | 23 |
the prevention of | 23 |
protective role of | 23 |
both ace and | 22 |
high blood pressure | 22 |
and function of | 22 |
converting enzyme angiotensin | 22 |
step in understanding | 22 |
in vitro studies | 22 |
in the circulation | 22 |
to study the | 22 |
in the pathophysiology | 22 |
is an important | 22 |
protein of sars | 22 |
a first step | 22 |
the interaction of | 22 |
ang ii formation | 22 |
the classical ras | 22 |
lung injury in | 22 |
of the most | 22 |
endogenous ligand for | 22 |
as a potential | 22 |
known to be | 22 |
the lack of | 22 |
rat model of | 22 |
the upregulation of | 22 |
structure and function | 22 |
of nitric oxide | 22 |
results showed that | 22 |
increase in ace | 22 |
as a captopril | 22 |
which in turn | 22 |
the case of | 22 |
in this work | 22 |
the ace angiotensin | 22 |
the mechanism of | 22 |
ace is the | 22 |
amyotrophic lateral sclerosis | 22 |
the b receptor | 22 |
of cardiovascular disease | 22 |
caused by the | 22 |
within the kidney | 22 |
binds to the | 22 |
in individuals with | 22 |
for the g | 22 |
in understanding sars | 22 |
the concentrations of | 22 |
understanding sars pathogenesis | 22 |
this study was | 22 |
retrospective cohort study | 21 |
in the case | 21 |
the plasma membrane | 21 |
the concentration of | 21 |
of recombinant human | 21 |
the metabolism of | 21 |
ace and tmprss | 21 |
patients with coronavirus | 21 |
of the c | 21 |
hek t cells | 21 |
of acute lung | 21 |
in acute respiratory | 21 |
arm of the | 21 |
of myocardial infarction | 21 |
protected by copyright | 21 |
h c cells | 21 |
and mortality in | 21 |
thought to be | 21 |
the ras system | 21 |
of ace inhibitor | 21 |
article is protected | 21 |
ang i is | 21 |
oxidative stress and | 21 |
with normal pregnancies | 21 |
and the renin | 21 |
mrna and protein | 21 |
may be a | 21 |
as a therapeutic | 21 |
of human angiotensin | 21 |
it is possible | 21 |
suggest that the | 21 |
be due to | 21 |
is protected by | 21 |
as a receptor | 21 |
ii and na | 21 |
in the early | 21 |
in a mouse | 21 |
the number of | 21 |
ace activity was | 21 |
r and at | 21 |
of the severe | 21 |
amino acids and | 21 |
the reduction in | 20 |
campbell et al | 20 |
play an important | 20 |
present in the | 20 |
in this review | 20 |
at receptor antagonists | 20 |
the administration of | 20 |
crucial role in | 20 |
is thought to | 20 |
inhibition and angiotensin | 20 |
are presented as | 20 |
mediated by the | 20 |
h n virus | 20 |
administration of ang | 20 |
has been described | 20 |
of coronavirus disease | 20 |
in experimental models | 20 |
is increased in | 20 |
the novel coronavirus | 20 |
expression of ang | 20 |
were found to | 20 |
was carried out | 20 |
for the development | 20 |
is responsible for | 20 |
epithelial cells and | 20 |
expression and activity | 20 |
of the first | 20 |
was able to | 20 |
benefits of ace | 20 |
that can be | 20 |
ang ii was | 20 |
enzyme inhibition and | 20 |
the cell membrane | 20 |
and characterization of | 20 |
the ras and | 20 |
of inflammatory cytokines | 20 |
synthesis of the | 20 |
form of ace | 20 |
its role in | 20 |
well as in | 20 |
the ace inhibitor | 20 |
effects on the | 20 |
of the complement | 20 |
therapeutic target for | 20 |
converted to ang | 20 |
is required for | 20 |
ectodomain shedding of | 20 |
has been demonstrated | 20 |
are involved in | 20 |
of ace ang | 20 |
the majority of | 20 |
many of the | 20 |
of at receptor | 20 |
mas axis in | 20 |
ace inhibition in | 20 |
for the synthesis | 19 |
inflammatory effects of | 19 |
is reduced in | 19 |
expression of at | 19 |
been found to | 19 |
shedding of the | 19 |
as compared to | 19 |
will be presented | 19 |
those of ang | 19 |
a retrospective cohort | 19 |
alveolar epithelial cells | 19 |
endothelial cells and | 19 |
for the first | 19 |
results suggest that | 19 |
a range of | 19 |
the immune system | 19 |
the reduction of | 19 |
at r expression | 19 |
at the c | 19 |
to those of | 19 |
acei or arb | 19 |
the binding of | 19 |
data suggest that | 19 |
sympathetic nervous system | 19 |
reduction in the | 19 |
the context of | 19 |
several studies have | 19 |
and oxidative stress | 19 |
been identified in | 19 |
enzyme activity in | 19 |
in diabetic nephropathy | 19 |
a receptor for | 19 |
by ace inhibition | 19 |
ace gene expression | 19 |
protective effect of | 19 |
between ace and | 19 |
is the main | 19 |
i and ii | 19 |
shown that the | 19 |
bradykinin b receptor | 19 |
regulation of ace | 19 |
myocardial infarction in | 19 |
a key role | 19 |
the most important | 19 |
was supported by | 19 |
to angiotensin ii | 19 |
have also been | 19 |
the severe acute | 19 |
the first time | 19 |
the s protein | 19 |
on ang ii | 19 |
with ace inhibitors | 19 |
revealed that the | 19 |
may also be | 19 |
acute myocardial infarction | 19 |
the ace receptor | 19 |
infected with sars | 19 |
on the cell | 19 |
ace inhibitors or | 19 |
the amino acid | 19 |
a protective role | 18 |
at least in | 18 |
serve as a | 18 |
implicated in the | 18 |
by ace inhibitors | 18 |
in the mouse | 18 |
patients infected with | 18 |
function of the | 18 |
effects in the | 18 |
view of the | 18 |
to that of | 18 |
on the surface | 18 |
role for the | 18 |
in this regard | 18 |
ang ii effects | 18 |
transgenic mice with | 18 |
in the renal | 18 |
to generate ang | 18 |
and lung injury | 18 |
our understanding of | 18 |
the degree of | 18 |
mrna expression of | 18 |
to investigate the | 18 |
women with pe | 18 |
increased in the | 18 |
is a key | 18 |
ace levels in | 18 |
by means of | 18 |
is the most | 18 |
appears to be | 18 |
receptor blockers on | 18 |
with ace inhibitor | 18 |
has been suggested | 18 |
ace has been | 18 |
was observed in | 18 |
and expression of | 18 |
and progression of | 18 |
led to the | 18 |
women with normal | 18 |
is characterized by | 18 |
the stimulation of | 18 |
to have a | 18 |
converting enzyme type | 18 |
which is the | 18 |
of this study | 18 |
the result of | 18 |
in failing human | 17 |
levels and activity | 17 |
protective effects of | 17 |
cleavage of the | 17 |
shown in fig | 17 |
is a potent | 17 |
the angiotensin converting | 17 |
the cleavage of | 17 |
ang ii into | 17 |
leads to the | 17 |
the authors declare | 17 |
in the context | 17 |
and the at | 17 |
decrease in the | 17 |
at receptor antagonist | 17 |
of the renal | 17 |
ace expression is | 17 |
is present in | 17 |
urinary levels of | 17 |
consistent with the | 17 |
role for ace | 17 |
lung tumor tissue | 17 |
component of the | 17 |
important role of | 17 |
experimental models of | 17 |
in the renin | 17 |
were observed in | 17 |
a critical role | 17 |
use of ace | 17 |
been associated with | 17 |
vsels and hscs | 17 |
as previously described | 17 |
plasma renin activity | 17 |
this work was | 17 |
with novel coronavirus | 17 |
functions as a | 17 |
of novel coronavirus | 17 |
via the at | 17 |
levels of the | 17 |
the distribution of | 17 |
ace levels and | 17 |
regulation of blood | 17 |
resulting in the | 17 |
diabetic kidney disease | 17 |
response to ang | 17 |
identified in the | 17 |
binding of the | 17 |
vascular endothelial cells | 17 |
expression in human | 17 |
of the protein | 17 |
the combination of | 17 |
in vascular smooth | 17 |
ang ii production | 17 |
in the kidneys | 17 |
the spontaneously hypertensive | 17 |
supplementary figure s | 17 |
classical raas axis | 17 |
be related to | 17 |
action of ang | 17 |
through activation of | 17 |
a central role | 17 |
used for the | 17 |
interaction with the | 17 |
aldosterone system inhibitors | 17 |
is the first | 17 |
p r o | 17 |
hospitalized patients with | 17 |
amino acid transporter | 17 |
zhang et al | 17 |
inhibitors in patients | 17 |
ii levels in | 17 |
hypertrophy and fibrosis | 16 |
wide variety of | 16 |
the healthy individuals | 16 |
circulating levels of | 16 |
the cells were | 16 |
target for the | 16 |
to understand the | 16 |
inhibitors and arbs | 16 |
the induction of | 16 |
associated with covid | 16 |
ace activity is | 16 |
the immune response | 16 |
receptor in the | 16 |
it was found | 16 |
the blood pressure | 16 |
coronavirus spike protein | 16 |
it is known | 16 |
studies on the | 16 |
the raas is | 16 |
can be used | 16 |
the identification of | 16 |
ace levels were | 16 |
when compared with | 16 |
induced by ang | 16 |
overexpression of ace | 16 |
failing human heart | 16 |
be responsible for | 16 |
domain of ace | 16 |
been reported in | 16 |
as a consequence | 16 |
db db mice | 16 |
is located on | 16 |
in hypertensive patients | 16 |
results of the | 16 |
in the proximal | 16 |
but not in | 16 |
by the action | 16 |
normal lung tissue | 16 |
ace is an | 16 |
acute kidney injury | 16 |
and neprilysin in | 16 |
in terms of | 16 |
of the novel | 16 |
to reduce the | 16 |
the proximal tubule | 16 |
involvement of the | 16 |
activated protein kinase | 16 |
are mediated by | 16 |
mas receptor in | 16 |
basis for the | 16 |
the course of | 16 |
ace protein expression | 16 |
patients with diabetes | 16 |
left ventricular dysfunction | 16 |
gene expression in | 16 |
to produce ang | 16 |
heart and kidney | 16 |
from patients with | 16 |
heart failure patients | 16 |
in a variety | 16 |
the structure and | 16 |
ace expression and | 16 |
production of angiotensin | 16 |
roles of angiotensin | 16 |
as compared with | 16 |
donoghue et al | 16 |
mrna expression in | 16 |
no conflict of | 16 |
to play a | 16 |
cell proliferation and | 16 |
suppressed ang ii | 16 |
been detected in | 16 |
and protein expression | 16 |
ace and neprilysin | 16 |
for ace in | 16 |
in cardiovascular and | 16 |
approved by the | 16 |
function of ace | 16 |
left ventricular hypertrophy | 16 |
systolic blood pressure | 16 |
identified as a | 16 |
ang ii ang | 16 |
evidence suggests that | 15 |
with type diabetes | 15 |
the complement system | 15 |
mortality in patients | 15 |
critically ill patients | 15 |
in ace expression | 15 |
upregulation of the | 15 |
of podocyte injury | 15 |
ang ii can | 15 |
in relation to | 15 |
in the shr | 15 |
to inhibit the | 15 |
j o u | 15 |
roles of the | 15 |
been found in | 15 |
l p r | 15 |
r n a | 15 |
expression levels of | 15 |
ang i into | 15 |
n a l | 15 |
blood pressure elevation | 15 |
in association with | 15 |
oxidative stress in | 15 |
for heart failure | 15 |
in the plasma | 15 |
and regulation of | 15 |
in the angiotensin | 15 |
and septic shock | 15 |
we have shown | 15 |
p r e | 15 |
studies have demonstrated | 15 |
o u r | 15 |
and risk of | 15 |
the in vivo | 15 |
associated with an | 15 |
in the same | 15 |
ii and angiotensin | 15 |
in the liver | 15 |
characterization of a | 15 |
upregulation of ace | 15 |
at receptor stimulation | 15 |
indicate that the | 15 |
of neutral endopeptidase | 15 |
with the ace | 15 |
physiological and pathological | 15 |
did not affect | 15 |
presence of ace | 15 |
expression of mir | 15 |
concentration of ang | 15 |
r o o | 15 |
the results of | 15 |
the rate of | 15 |
to increase the | 15 |
and nitric oxide | 15 |
cd t cells | 15 |
effects of losartan | 15 |
was performed in | 15 |
regulated ectodomain shedding | 15 |
spontaneously hypertensive rat | 15 |
in critically ill | 15 |
hypertensive rats angiotensin | 15 |
phase peptide synthesis | 15 |
of ace by | 15 |
are needed to | 15 |
mediates regulated ectodomain | 15 |
negative regulator of | 15 |
of ace on | 15 |
u r n | 15 |
and cardiovascular disease | 15 |
decreased expression of | 15 |
and found that | 15 |
may be involved | 15 |
treated with ace | 15 |
presence of the | 15 |
considered to be | 15 |
and smooth muscle | 15 |
of ace to | 15 |
airway epithelial cells | 15 |
activation of ace | 15 |
previous studies have | 15 |
is a major | 15 |
cardiovascular effects of | 15 |
the onset of | 15 |
interaction of the | 15 |
a l p | 15 |
at receptor blockade | 15 |
the mineralocorticoid receptor | 15 |
ace is expressed | 15 |
a therapeutic target | 15 |
genetic deletion of | 15 |
was found that | 15 |
o o f | 15 |
insights into the | 15 |
actions of the | 15 |
ang ii were | 15 |
heart failure in | 15 |
reduction of the | 15 |
to the at | 15 |
the significance of | 15 |
a model of | 15 |
risk factors for | 15 |
of these peptides | 15 |
at receptor activation | 15 |
in the ang | 15 |
of angiotensinconverting enzyme | 15 |
it is well | 15 |
action of angiotensin | 15 |
expression in rat | 15 |
results in the | 15 |
which is a | 15 |
aim of this | 15 |
of angiotensin receptor | 15 |
can also be | 15 |
of cell volume | 15 |
ang ii has | 15 |
increased ace expression | 15 |
of oxidative stress | 15 |
rostral ventrolateral medulla | 14 |
active site of | 14 |
the mechanisms of | 14 |
upregulation of mir | 14 |
have not been | 14 |
in some cases | 14 |
individuals with diabetes | 14 |
of the protective | 14 |
in the gut | 14 |
in a study | 14 |
vickers et al | 14 |
key role in | 14 |
ang ii signaling | 14 |
may play a | 14 |
at receptor and | 14 |
degradation of ang | 14 |
ace inhibitors in | 14 |
of resveratrol on | 14 |
ischaemic heart disease | 14 |
or ang ii | 14 |
by the ace | 14 |
the possibility of | 14 |
angiotensin ii induces | 14 |
and risk factors | 14 |
ace in human | 14 |
the decrease in | 14 |
protein expression of | 14 |
patients treated with | 14 |
plasminogen activator inhibitor | 14 |
a wide variety | 14 |
is found in | 14 |
axis in the | 14 |
the hypothesis that | 14 |
metabolism in the | 14 |
patients with type | 14 |
of ace activity | 14 |
to the formation | 14 |
was reported to | 14 |
there were no | 14 |
may be an | 14 |
spike protein of | 14 |
blocked by a | 14 |
found that ace | 14 |
by binding to | 14 |
i converting enzyme | 14 |
fluid and electrolyte | 14 |
ferrario et al | 14 |
for ace and | 14 |
the recognition of | 14 |
by inhibiting the | 14 |
risk factor for | 14 |
activation of nf | 14 |
cleaved by ace | 14 |
may be due | 14 |
metabolism of angiotensin | 14 |
corresponding to the | 14 |
wide range of | 14 |
risk of covid | 14 |
a study of | 14 |
in acute lung | 14 |
stimulation of at | 14 |
syndrome coronavirus infection | 14 |
of hypertension and | 14 |
used as a | 14 |
and in vitro | 14 |
and fibrosis in | 14 |
for multiple comparisons | 14 |
be used in | 14 |
it is also | 14 |
that the expression | 14 |
have been found | 14 |
were purchased from | 14 |
demonstrated that the | 14 |
of action of | 14 |
increased blood pressure | 14 |
treatment of hypertension | 14 |
mechanism of action | 14 |
crystal structure of | 14 |
nucleus of the | 14 |
of the active | 14 |
blood pressure by | 14 |
and can be | 14 |
plasma ang ii | 14 |
development of new | 14 |
metabolism of ang | 14 |
release of vasopressin | 14 |
have been developed | 14 |
the components of | 14 |
in the spontaneously | 14 |
is known that | 14 |
the downregulation of | 14 |
addition to its | 14 |
of the study | 14 |
diseases such as | 14 |
in subjects with | 14 |
lung injury and | 14 |
central role in | 14 |
has recently been | 14 |
p and mir | 14 |
were able to | 14 |
of ras in | 14 |
than that of | 14 |
similar to those | 14 |
essential role in | 14 |
reported that the | 14 |
and clinical studies | 14 |
a combination of | 14 |
ace is not | 14 |
demonstrated that ang | 14 |
severity of covid | 14 |
be used as | 14 |
mice per group | 14 |
suggests that the | 14 |
the benefits of | 14 |
ratio of ace | 14 |
there was no | 14 |
of the alternative | 14 |
leading to a | 14 |
of hospitalized patients | 14 |
n mice per | 14 |
inhibition of ace | 14 |
decrease in ace | 14 |
the extent of | 13 |
these data suggest | 13 |
significantly higher than | 13 |
critical role in | 13 |
c bl mice | 13 |
in comparison with | 13 |
the balance of | 13 |
clinical course and | 13 |
peptide in the | 13 |
characterization of the | 13 |
significantly increased in | 13 |
inhibitors of angiotensin | 13 |
identification of a | 13 |
at receptor blockers | 13 |
is a novel | 13 |
intensive care unit | 13 |
ace inhibitor or | 13 |
the ability to | 13 |
east respiratory syndrome | 13 |
and ace levels | 13 |
effects of captopril | 13 |
may be the | 13 |
that activation of | 13 |
vascular inflammation and | 13 |
cyp b and | 13 |
the sympathetic nervous | 13 |
a role of | 13 |
and its receptor | 13 |
and is associated | 13 |
of reactive oxygen | 13 |
importance of ace | 13 |
is critical for | 13 |
with regard to | 13 |
and h c | 13 |
analysis revealed that | 13 |
in the expression | 13 |
as a key | 13 |
remodeling and pah | 13 |
brosnihan et al | 13 |
cov and sars | 13 |
to ace inhibitors | 13 |
of a new | 13 |
no effect on | 13 |
was identified as | 13 |
blockers on cardiac | 13 |
loss of angiotensin | 13 |
balance between the | 13 |
use of angiotensin | 13 |
lung injury angiotensin | 13 |
on ace and | 13 |
antihypertensive effects of | 13 |
angiotensin receptor blocker | 13 |
experimental and clinical | 13 |
has been proposed | 13 |
discovery of ace | 13 |
found that ang | 13 |
characterized by a | 13 |
i into ang | 13 |
with an increase | 13 |
in serum of | 13 |
been identified as | 13 |
have been proposed | 13 |
middle east respiratory | 13 |
contrast to the | 13 |
is blocked by | 13 |
been suggested that | 13 |
an at receptor | 13 |
bind to the | 13 |
of the rat | 13 |
that has been | 13 |
cytokines such as | 13 |
of the effects | 13 |
the biological activity | 13 |
in the pulmonary | 13 |
for treatment of | 13 |
system inhibitors in | 13 |
a potential therapeutic | 13 |
responses to ang | 13 |
and angiotensin converting | 13 |
the association of | 13 |
development of cardiac | 13 |
the classical raas | 13 |
profiling of ace | 13 |
in the s | 13 |
cytokines and chemokines | 13 |
the preparation of | 13 |
that the ace | 13 |
ang ii accumulation | 13 |
insertion deletion polymorphism | 13 |
of these drugs | 13 |
evidence for the | 13 |
and tmprss and | 13 |
in vivo and | 13 |
ii to the | 13 |
the same time | 13 |
enzyme inhibition in | 13 |
ii into ang | 13 |
been implicated in | 13 |
plays a role | 13 |
at r is | 13 |
the rostral ventrolateral | 13 |
in the nucleus | 13 |
the amount of | 13 |
studies are needed | 13 |
lung injury by | 13 |
a reduction of | 13 |
is cleaved by | 13 |
in the metabolism | 13 |
an essential role | 13 |
from the cell | 13 |
depends on ace | 13 |
and safety of | 13 |
of the heart | 13 |
in our study | 13 |
in transgenic rats | 13 |
cardiac function and | 13 |
expressed on the | 13 |
ras has been | 13 |
expression profiling of | 13 |
shedding of ace | 13 |
or at receptor | 13 |
in ace levels | 13 |
but did not | 13 |
ace ace ratio | 13 |
and chronic kidney | 13 |
has been identified | 13 |
and has been | 13 |
is highly expressed | 13 |
from the rat | 13 |
ace inhibitors are | 13 |
gs and bs | 13 |
of the nlrp | 13 |
of ace has | 13 |
for disease control | 13 |
presented as the | 13 |
in a model | 13 |
ang ii could | 13 |
acei and arb | 13 |
remains to be | 13 |
mechanism by which | 13 |
proven to be | 13 |
conversion of angiotensin | 13 |
gene expression of | 13 |
of the receptor | 13 |
with severe covid | 13 |
regulation of cardiovascular | 13 |
at the n | 13 |
to form ang | 13 |
endothelial dysfunction and | 13 |
also associated with | 13 |
at the same | 12 |
step in the | 12 |
for min at | 12 |
higher risk of | 12 |
there is an | 12 |
normotensive and hypertensive | 12 |
against ang ii | 12 |
released into the | 12 |
was confirmed by | 12 |
serum levels of | 12 |
may have a | 12 |
mortality of adult | 12 |
shown that ace | 12 |
the association between | 12 |
such as hypertension | 12 |
ii receptor antagonist | 12 |
to assess the | 12 |
was assessed by | 12 |
has been observed | 12 |
been proposed to | 12 |
homolog of ace | 12 |
inhibitors and at | 12 |
of this system | 12 |
angiotensin and bradykinin | 12 |
ang ii are | 12 |
the receptor for | 12 |
prevention and treatment | 12 |
in human airway | 12 |
specificity of the | 12 |
of cardiovascular function | 12 |
the study was | 12 |
cell entry depends | 12 |
in ace knockout | 12 |
located on the | 12 |
shown to have | 12 |
functions of the | 12 |
impact on the | 12 |
factors for mortality | 12 |
in kidney disease | 12 |
the impact of | 12 |
as a new | 12 |
or arb use | 12 |
together with the | 12 |
are shown in | 12 |
the management of | 12 |
were analyzed using | 12 |
and ace inhibitors | 12 |
to interact with | 12 |
at receptor in | 12 |
by a clinically | 12 |
role for ang | 12 |
removal of the | 12 |
synthesis of a | 12 |
such as il | 12 |
potential therapeutic target | 12 |
inhibition of sars | 12 |
members of the | 12 |
levels of angiotensin | 12 |
patients with acute | 12 |
of the glomerular | 12 |
of this peptide | 12 |
for patients with | 12 |
risk of cancer | 12 |
in the cardiac | 12 |
recombinant human angiotensin | 12 |
concentrations of resveratrol | 12 |
of the cytokine | 12 |
structural basis for | 12 |
de ang ii | 12 |
induced cellular hypertrophy | 12 |
there was a | 12 |
we have developed | 12 |
leads to a | 12 |
which could be | 12 |
the peptide in | 12 |
new class of | 12 |
by the use | 12 |
cleavage of ang | 12 |
in plasma and | 12 |
human ace in | 12 |
inhibition of ang | 12 |
between the two | 12 |
work was supported | 12 |
in severe covid | 12 |
biological activity of | 12 |
the current study | 12 |
of sars coronavirus | 12 |
formation of the | 12 |
viral entry into | 12 |
that of the | 12 |
with essential hypertension | 12 |
at or at | 12 |
angiotensin at receptor | 12 |
were incubated with | 12 |
ace plays a | 12 |
by the at | 12 |
as an important | 12 |
in the gastrointestinal | 12 |
reported to be | 12 |
at receptor gene | 12 |
is also a | 12 |
and the ace | 12 |
and activity of | 12 |
is important to | 12 |
higher than that | 12 |
to be associated | 12 |
is due to | 12 |
effects of at | 12 |
ii at receptor | 12 |
ko mice showed | 12 |
in ace and | 12 |
the interaction between | 12 |
induced acute lung | 12 |
like stem cells | 12 |
endothelial dysfunction in | 12 |
dysregulation of the | 12 |
upregulation of angiotensin | 12 |
chen et al | 12 |
not able to | 12 |
compared to ang | 12 |
as the mean | 12 |
dependent on the | 12 |
therapy in patients | 12 |
ang ii may | 12 |
there are no | 12 |
of the b | 12 |
at a receptor | 12 |
inpatients with covid | 12 |
type ii pneumocytes | 12 |
and patients with | 12 |
it is a | 12 |
the maintenance of | 12 |
control and prevention | 12 |
is possible that | 12 |
and na in | 12 |
of the peptides | 12 |
a clinically proven | 12 |
are thought to | 12 |
adult inpatients with | 12 |
evidence that the | 12 |
been shown that | 12 |
molecular mechanisms of | 12 |
of the central | 12 |
homologue of ace | 12 |
the angiotensin type | 12 |
has shown that | 12 |
angiotensin aldosterone system | 12 |
the introduction of | 12 |
activation of prorenin | 12 |
this suggests that | 12 |
of ace was | 12 |
to be involved | 12 |
data not shown | 12 |
showed that ang | 12 |
very small embryonic | 12 |
to improve the | 12 |
the influence of | 12 |
proven protease inhibitor | 12 |
in the generation | 12 |
a wide range | 12 |
clinically proven protease | 12 |
and is blocked | 12 |
by blockade of | 12 |
level of ang | 12 |
course and risk | 12 |
of type diabetes | 12 |
kidney disease and | 12 |
of somatic ace | 12 |
reduction in ace | 12 |
regulation of cell | 12 |
entry depends on | 12 |
by ace to | 12 |
the most common | 12 |
tmprss and is | 12 |
in the progression | 12 |
amino acid transporters | 12 |
mediated by at | 12 |
of adult inpatients | 12 |
mutations in the | 12 |
for mortality of | 12 |
ii is a | 11 |
have been described | 11 |
the detection of | 11 |
the renin receptor | 11 |
based on a | 11 |
the development and | 11 |
endothelial nitric oxide | 11 |
ii production and | 11 |
of the role | 11 |
complexity of the | 11 |
the complexity of | 11 |
fetal bovine serum | 11 |
in rat brain | 11 |
disease in china | 11 |
avian influenza virus | 11 |
higher levels of | 11 |
binding to ace | 11 |
is able to | 11 |
in the current | 11 |
is induced by | 11 |
activation of at | 11 |
peptide levels in | 11 |
due to their | 11 |
were synthesized and | 11 |
roles in the | 11 |
increased production of | 11 |
of an angiotensin | 11 |
polymerase chain reaction | 11 |
a cytokine storm | 11 |
enzyme in human | 11 |
pathways of the | 11 |
ii by ace | 11 |
in these patients | 11 |
may serve as | 11 |
health and disease | 11 |
smooth muscle cell | 11 |
into ang ii | 11 |
on the x | 11 |
based on these | 11 |
glomerular basement membrane | 11 |
shown that ang | 11 |
in apelin ko | 11 |
increase in blood | 11 |
study of the | 11 |
ace transgenic mice | 11 |
human angiotensinconverting enzyme | 11 |
which has been | 11 |
enzyme inhibition on | 11 |
which leads to | 11 |
binding of ang | 11 |
can lead to | 11 |
we showed that | 11 |
converting enzymerelated carboxypeptidase | 11 |
progression of diabetic | 11 |
to explore the | 11 |
to the ace | 11 |
contributed to the | 11 |
circulating ang ii | 11 |
further studies are | 11 |
angiotensin i converting | 11 |
converting enzyme homologue | 11 |
in rat and | 11 |
the expression and | 11 |
ang i by | 11 |
within the brain | 11 |
regions of the | 11 |
its interaction with | 11 |
to prevent the | 11 |
the basis of | 11 |
blood pressure control | 11 |
ace inhibition is | 11 |
and inflammation in | 11 |
of the activation | 11 |
localized to the | 11 |
cardiac and renal | 11 |
the adrenal gland | 11 |
cytokine storm and | 11 |
findings suggest that | 11 |
effects of these | 11 |
ang ii binds | 11 |
angiotensin peptides in | 11 |
gs bs patients | 11 |
ace null mice | 11 |
the synthesis and | 11 |
development of a | 11 |
the x chromosome | 11 |
left ventricular remodeling | 11 |
the metabolite formation | 11 |
ace mrna expression | 11 |
with respect to | 11 |
the antihypertensive effects | 11 |
as ang ii | 11 |
the incidence of | 11 |
innate immune response | 11 |
in the formation | 11 |
in engineered human | 11 |
effect of losartan | 11 |
referred to as | 11 |
ii binds to | 11 |
infusion of ang | 11 |
contributing to the | 11 |
was significantly reduced | 11 |
similar to that | 11 |
the attachment of | 11 |
ace mrna and | 11 |
in angiotensin peptide | 11 |
weeks of gestation | 11 |
ace may be | 11 |
gene expression and | 11 |
type receptor blockade | 11 |
suggested that the | 11 |
been linked to | 11 |
at receptor expression | 11 |
in the rostral | 11 |
on cardiac angiotensin | 11 |
blood pressure responses | 11 |
human angiotensin i | 11 |
located on chromosome | 11 |
these findings suggest | 11 |
disease control and | 11 |
administration of recombinant | 11 |
to the antihypertensive | 11 |
of the s | 11 |
angiotensin peptides and | 11 |
the growth of | 11 |
at least two | 11 |
effects of ras | 11 |
seem to be | 11 |
high level of | 11 |
modulation of the | 11 |
effect of resveratrol | 11 |
myocardial infarction and | 11 |
the setting of | 11 |
blood flow and | 11 |
in vascular endothelial | 11 |
also been shown | 11 |
ii levels were | 11 |
genetic ace deficiency | 11 |
is converted to | 11 |
the ras has | 11 |
seems to be | 11 |
and sudden death | 11 |
an upregulation of | 11 |
study showed that | 11 |
the observation that | 11 |
by activation of | 11 |
first time that | 11 |
of left ventricular | 11 |
the kidney of | 11 |
the complement cascade | 11 |
region of the | 11 |
ang ii also | 11 |
are responsible for | 11 |
efficacy and safety | 11 |
glomerular injury in | 11 |
ii and the | 11 |
blockade of angiotensin | 11 |
mechanism of the | 11 |
was determined by | 11 |
in the aorta | 11 |
salt and water | 11 |
demonstrated that ace | 11 |
blood pressure was | 11 |
pathogenesis of covid | 11 |
american heart association | 11 |
for the prevention | 11 |
et al b | 11 |
in accordance with | 11 |
forming activity in | 11 |
resulted in the | 11 |
i or ang | 11 |
role in maintaining | 11 |
a significant role | 11 |
the proximal tubules | 11 |
elevated blood pressure | 11 |
to form the | 11 |
been demonstrated to | 11 |
with acute respiratory | 11 |
two active sites | 11 |
the brain and | 11 |
with chronic heart | 11 |
ang ii concentration | 11 |
amino acid sequence | 11 |
in the production | 11 |
of h n | 11 |
a and b | 11 |
were significantly higher | 11 |
heart failure with | 11 |
homologue of angiotensin | 11 |
proximal tubular cells | 11 |
of normal and | 11 |
protein kinase c | 11 |
surface of the | 11 |
data indicate that | 11 |
activity in failing | 11 |
xu et al | 11 |
lead to a | 11 |
ace and its | 11 |
months after ot | 11 |
of the patients | 11 |
ang ii treatment | 11 |
to ang i | 11 |
suggesting that the | 11 |
it is important | 11 |
type receptor in | 11 |
the application of | 11 |
properties of the | 11 |
localization of the | 11 |
of bradykinin by | 11 |
cigarette smoke exposure | 11 |
the results showed | 11 |
were treated with | 11 |
ang i or | 11 |
monocyte chemoattractant protein | 11 |
in comparison to | 11 |
has been associated | 11 |
we demonstrated that | 11 |
ii receptor subtypes | 11 |
due to a | 11 |
avian influenza a | 11 |
of human ace | 10 |
in the setting | 10 |
the changes in | 10 |
in human plasma | 10 |
be used to | 10 |
be an important | 10 |
the nucleus tractus | 10 |
a consequence of | 10 |
effects of feb | 10 |
in diabetic rats | 10 |
axes of the | 10 |
a review of | 10 |
of ace as | 10 |
that in the | 10 |
ang ii as | 10 |
we investigated the | 10 |
evidence for upregulation | 10 |
of ace are | 10 |
solid phase synthesis | 10 |
in essential hypertension | 10 |
generation of angiotensin | 10 |
and vascular smooth | 10 |
it was shown | 10 |
been observed in | 10 |
mortality and morbidity | 10 |
formation rate of | 10 |
ii receptor blocker | 10 |
et al a | 10 |
insight into the | 10 |
of these two | 10 |
the kidney and | 10 |
isolated perfused rat | 10 |
amino acids from | 10 |
inhibits growth of | 10 |
respiratory syncytial virus | 10 |
receptor blockers and | 10 |
data are presented | 10 |
related to increased | 10 |
for upregulation of | 10 |
in normal and | 10 |
the subfornical organ | 10 |
ang ii stimulation | 10 |
of renin and | 10 |
has been detected | 10 |
belongs to the | 10 |
the protein expression | 10 |
in human and | 10 |
potential target for | 10 |
cancer cell lines | 10 |
wang et al | 10 |
h n influenza | 10 |
probably due to | 10 |
to the c | 10 |
through inhibition of | 10 |
by the angiotensin | 10 |
result in the | 10 |
driven by the | 10 |
plays a crucial | 10 |
podocyte injury in | 10 |
to ace expression | 10 |
in the prevention | 10 |
in the cell | 10 |
least in part | 10 |
following myocardial infarction | 10 |
in gs bs | 10 |
outcomes in patients | 10 |
coronavirus disease in | 10 |
tissue levels of | 10 |
to examine the | 10 |
large number of | 10 |
with the development | 10 |
the circulating ras | 10 |
the proliferation of | 10 |
vascular remodeling and | 10 |
significant reduction of | 10 |
and development of | 10 |
prevention of angiotensin | 10 |
action of ace | 10 |
cells and the | 10 |
no significant difference | 10 |
mechanisms of the | 10 |
in the cns | 10 |
expression of cyp | 10 |
the process of | 10 |
and its expression | 10 |
also showed that | 10 |
the brain of | 10 |
in line with | 10 |
actions of ace | 10 |
its ability to | 10 |
mice treated with | 10 |
and endothelial dysfunction | 10 |
rats with myocardial | 10 |
those of the | 10 |
was found in | 10 |
active sites of | 10 |
is capable of | 10 |
severe and critical | 10 |
type diabetes and | 10 |
on the structure | 10 |
the angiotensin receptor | 10 |
of severe covid | 10 |
pivotal role of | 10 |
protein in the | 10 |
studies have reported | 10 |
terminal catalytic domain | 10 |
sudden death in | 10 |
be mediated by | 10 |
derived from the | 10 |
that there is | 10 |
a previous study | 10 |
to the renin | 10 |
a potential target | 10 |
receptor is the | 10 |
with at r | 10 |
the lungs of | 10 |
beneficial effect of | 10 |
amino acid from | 10 |
results from the | 10 |
angiotensin system angiotensin | 10 |
acei and arbs | 10 |
with hypertension and | 10 |
in clinical trials | 10 |
is based on | 10 |
of cardiac myocytes | 10 |
a significant reduction | 10 |
the site of | 10 |
in the hearts | 10 |
at receptor axis | 10 |
of natriuretic peptides | 10 |
are present in | 10 |
depending on the | 10 |
to an increase | 10 |
proteolytic cleavage of | 10 |
in this context | 10 |
was performed using | 10 |
in transgenic mice | 10 |
is regulated by | 10 |
compared with non | 10 |
followed by the | 10 |
of endogenous ang | 10 |
angiotensin ii on | 10 |
world health organization | 10 |
from the c | 10 |
the protective role | 10 |
based on this | 10 |
was significantly higher | 10 |
and inhibition of | 10 |
infusion of angiotensin | 10 |
regulation of angiotensin | 10 |
with high affinity | 10 |
metabolite formation rate | 10 |
crackower et al | 10 |
angiotensin system blockers | 10 |
been found that | 10 |
of the lungs | 10 |
human heart ventricles | 10 |
in the control | 10 |
characterization of angiotensin | 10 |
that ace may | 10 |
the united states | 10 |
of patients infected | 10 |
advanced glycation end | 10 |
and water retention | 10 |
severe heart failure | 10 |
authors declare that | 10 |
is well known | 10 |
did not have | 10 |
by treatment with | 10 |
significantly different from | 10 |
of mas receptor | 10 |
were synthesized by | 10 |
injury in mice | 10 |
their ability to | 10 |
the isolated perfused | 10 |
type diabetes mellitus | 10 |
of ace may | 10 |
the brain renin | 10 |
zhou et al | 10 |
catalytic activity of | 10 |
significantly higher in | 10 |
and arbs in | 10 |
cell growth and | 10 |
the respiratory system | 10 |
this effect was | 10 |
of hypertension in | 10 |
the innate immune | 10 |
was used for | 10 |
carried out in | 10 |
member of the | 10 |
r in the | 10 |
pi k akt | 10 |
have found that | 10 |
and mas receptor | 10 |
that patients with | 10 |
as a novel | 10 |
the secretion of | 10 |
results indicated that | 10 |
ang ii receptors | 10 |
to be an | 10 |
the specificity of | 10 |
i d polymorphism | 10 |
with myocardial infarction | 10 |
in ace transgenic | 10 |
rats angiotensin ii | 10 |
of expression of | 10 |
syndrome coronavirus spike | 10 |
be explained by | 10 |
aortic smooth muscle | 10 |
internalization and degradation | 10 |
infections in engineered | 10 |
in part by | 10 |
was increased in | 10 |
protective role in | 10 |
patients with primary | 10 |
of the virus | 10 |
high concentrations of | 10 |
department of chemistry | 10 |
soluble form of | 10 |
are related to | 10 |
hypertension and diabetes | 10 |
preserved ejection fraction | 10 |
plays a key | 10 |
as evidenced by | 10 |
and mas receptors | 10 |
of pulmonary hypertension | 10 |
for the recognition | 10 |
human tissues using | 10 |
isolated from the | 10 |
because of its | 10 |
has been implicated | 10 |
the occurrence of | 10 |
in h n | 10 |
was significantly increased | 10 |
research ethics committee | 10 |
the stability of | 10 |
system in cardiovascular | 10 |
a major role | 10 |
are known to | 10 |
when compared to | 10 |
the analysis of | 10 |
existence of a | 10 |
pulmonary vascular remodeling | 10 |
the study of | 10 |
induced by the | 10 |
in the acute | 10 |
glycosylation of ace | 10 |
downregulation of the | 10 |
inhibitors of the | 10 |
ace can be | 10 |
in the adult | 10 |
the accumulation of | 10 |
the lungs and | 10 |
designed and synthesized | 10 |
was blocked by | 10 |
that the use | 10 |
on the basis | 10 |
characteristics of coronavirus | 10 |
focused on the | 10 |
in health and | 10 |
angiotensin ii signaling | 10 |
engineered human tissues | 10 |
renal ang ii | 10 |
effect of captopril | 9 |
are required to | 9 |
release of the | 9 |
c cells were | 9 |
at doses of | 9 |
plasma and tissue | 9 |
enzyme as a | 9 |
in myocardial ischemia | 9 |
the left ventricle | 9 |
tissue ang ii | 9 |
renal injury in | 9 |
and other organs | 9 |
beneficial effects in | 9 |
induced diabetic mice | 9 |
and activity in | 9 |
pneumonia in wuhan | 9 |
novel coronavirus in | 9 |
in diabetic mice | 9 |
as part of | 9 |
significant role in | 9 |
and vascular endothelial | 9 |
at tissue sites | 9 |
prevention of pulmonary | 9 |
converting enzyme by | 9 |
urinary excretion of | 9 |
and increase in | 9 |
of renin in | 9 |
studies suggest that | 9 |
role of ras | 9 |
in cardiac hypertrophy | 9 |
in cardiovascular diseases | 9 |
in the late | 9 |
which results in | 9 |
shown to inhibit | 9 |
death in ace | 9 |
in lung tumor | 9 |
there have been | 9 |
after ang ii | 9 |
on angiotensin and | 9 |
hypertension in the | 9 |
cardiac fibrosis in | 9 |
could lead to | 9 |
patients with left | 9 |
of inflammatory cells | 9 |
form of the | 9 |
learning and memory | 9 |
of the gut | 9 |
ang ii with | 9 |
well known that | 9 |
influence on the | 9 |
a member of | 9 |
an animal model | 9 |
induced cardiac fibrosis | 9 |
in normal lung | 9 |
is linked to | 9 |
biologically active peptides | 9 |
activated protein kinases | 9 |
of the cell | 9 |
receptor binding domain | 9 |
increase of endocan | 9 |
of brain ras | 9 |
depends on the | 9 |
ang ii from | 9 |
were associated with | 9 |
in the failing | 9 |
amino acids are | 9 |
system blockers and | 9 |
glomerular filtration rate | 9 |
renal function in | 9 |
of ace gene | 9 |
the university of | 9 |
of the inflammatory | 9 |
under the control | 9 |
and water transport | 9 |
statistical significance was | 9 |
detected in the | 9 |
signaling in the | 9 |
decompensated heart failure | 9 |
ace to ace | 9 |
as a carboxypeptidase | 9 |
significant increase in | 9 |
and ulcerative colitis | 9 |
in a number | 9 |
overexpression of angiotensin | 9 |
patients in the | 9 |
was approved by | 9 |
and may be | 9 |
in the intestine | 9 |
therapeutic target in | 9 |
soluble human ace | 9 |
conformation of the | 9 |
with chronic kidney | 9 |
of ace with | 9 |
diabetes mellitus and | 9 |
of the membrane | 9 |
were found in | 9 |
human coronavirus nl | 9 |
patients with coronary | 9 |
at r by | 9 |
and cardiovascular diseases | 9 |
seen in the | 9 |
on the heart | 9 |
compared with normal | 9 |
in view of | 9 |
human recombinant ace | 9 |
in ace activity | 9 |
most of these | 9 |
the physiological and | 9 |
angiotensin ii stimulates | 9 |
the last decade | 9 |
nitric oxide and | 9 |
degradation of angiotensin | 9 |
of ras inhibitors | 9 |
severity of disease | 9 |
correlated inversely with | 9 |
ferreira et al | 9 |
ii has been | 9 |
the conformation of | 9 |
the design and | 9 |
to the apical | 9 |
ace and mas | 9 |
in keeping with | 9 |
did not significantly | 9 |
increases ace expression | 9 |
b and its | 9 |
in the serum | 9 |
of local renin | 9 |
there is evidence | 9 |
cases of covid | 9 |
this study is | 9 |
be used for | 9 |
infarction in rats | 9 |
ii and its | 9 |
in regulation of | 9 |
angiotensin system inhibitors | 9 |
appeared to be | 9 |
a negative regulator | 9 |
with a reduction | 9 |
analysis of randomized | 9 |
suggesting that ace | 9 |
reduction of ace | 9 |
control of the | 9 |
receptor for ang | 9 |
inhibitors of ace | 9 |
overexpression of human | 9 |
its homologue ace | 9 |
of the three | 9 |
induced cardiac dysfunction | 9 |
of the reaction | 9 |
the addition of | 9 |
normal cardiac phenotype | 9 |
serum ace and | 9 |
cell entry and | 9 |
results are presented | 9 |
site in the | 9 |
neurons in the | 9 |
system by angiotensin | 9 |
with left ventricular | 9 |
cells were incubated | 9 |
attenuates angiotensin ii | 9 |
de la eca | 9 |
to at r | 9 |
ang ii synthesis | 9 |
in the synthesis | 9 |
cellular responses to | 9 |
significance of the | 9 |
release of cytokines | 9 |
in cardiac myocytes | 9 |
ii or ang | 9 |
in the pancreas | 9 |
center for disease | 9 |
for h at | 9 |
accumulation of ang | 9 |
as shown by | 9 |
in case of | 9 |
plasma membrane of | 9 |
design of the | 9 |
cytochrome p b | 9 |
ii as a | 9 |
ace inhibitor arb | 9 |
the incorporation of | 9 |
and as a | 9 |
peptides and proteins | 9 |
for the ace | 9 |
no significant differences | 9 |
participate in the | 9 |
ace inhibitor and | 9 |
glycation end products | 9 |
the contribution of | 9 |
mainly in the | 9 |
for h with | 9 |
consistent with our | 9 |
single amino acid | 9 |
linked to the | 9 |
chain hete metabolites | 9 |
structural and functional | 9 |
importance of the | 9 |
development of heart | 9 |
physiological roles of | 9 |
society of cardiology | 9 |
there has been | 9 |
the angiotensin iv | 9 |
act as a | 9 |
treatment with the | 9 |
deletion of angiotensin | 9 |
produced by the | 9 |
mouse and rat | 9 |
is a highly | 9 |
of spontaneously hypertensive | 9 |
system in heart | 9 |
reach statistical significance | 9 |
with the aim | 9 |
acts as an | 9 |
as a potent | 9 |
of angiotensin type | 9 |
of the system | 9 |
in rats and | 9 |
ang ii on | 9 |
of proinflammatory cytokines | 9 |
to clarify the | 9 |
aldosterone system in | 9 |
of vascular endothelial | 9 |
the crystal structure | 9 |
encoded by the | 9 |
ang ii stimulates | 9 |
the extracellular matrix | 9 |
of the lung | 9 |
care and use | 9 |
of diabetes and | 9 |
the removal of | 9 |
we report the | 9 |
angiotensin ii production | 9 |
hypotensive effect of | 9 |
of ace mrna | 9 |
deshotels et al | 9 |
and pulmonary hypertension | 9 |
a protective effect | 9 |
the human heart | 9 |
to result in | 9 |
normal pregnant women | 9 |
patients with novel | 9 |
formation of a | 9 |
with a new | 9 |
mineralocorticoid receptor antagonist | 9 |
increased risk of | 9 |
mouse models of | 9 |
neurons of the | 9 |
the transcription factor | 9 |
has led to | 9 |
blockers and the | 9 |
in recent years | 9 |
early stages of | 9 |
enzyme homologue ace | 9 |
na in serum | 9 |
independent of the | 9 |
system and the | 9 |
and kidney disease | 9 |
in human heart | 9 |
ace was identified | 9 |
been attributed to | 9 |
and severity of | 9 |
podocyte injury and | 9 |
is a critical | 9 |
on the regulation | 9 |
to increased levels | 9 |
these results suggest | 9 |
murine model of | 9 |
therapeutic potential of | 9 |
of host cells | 9 |
of biologically active | 9 |
growth factor receptor | 9 |
nature of the | 9 |
gene expression is | 9 |
in the course | 9 |
ii receptor type | 9 |
renin prorenin receptor | 9 |
and ang i | 9 |
angiotensin peptide metabolism | 9 |
have indicated that | 9 |
gene is located | 9 |
length human ace | 9 |
development of glomerulosclerosis | 9 |
coronary heart disease | 9 |
physiological and pathophysiological | 9 |
mice with downregulated | 9 |
ace functions as | 9 |
not reach statistical | 9 |
showed that ace | 9 |
could be a | 9 |
of blockade of | 9 |
ang ii degradation | 9 |
peptides in the | 9 |
at receptor is | 9 |
renin angiotensin aldosterone | 9 |
did not reach | 9 |
to activation of | 9 |
to a reduction | 9 |
enhanced expression of | 9 |
in the last | 9 |
to the mas | 9 |
interactions with the | 9 |
of this article | 9 |
in the hypothalamus | 9 |
enzyme and its | 9 |
mas r axis | 9 |
of cardiovascular and | 9 |
feb suppressed ang | 9 |
cells were treated | 9 |
treated apelin ko | 9 |
human endothelial cells | 9 |
the hearts of | 9 |
of the major | 9 |
recent studies have | 9 |
blood flow in | 9 |
in agreement with | 9 |
at r has | 9 |
was added to | 9 |
deterioration of the | 9 |
by activating the | 9 |
and h o | 9 |
is considered to | 9 |
not associated with | 9 |
significantly reduced in | 9 |
p map kinase | 9 |
the c domain | 9 |
cardiac hypertrophy in | 9 |
and ace are | 9 |
discovery of the | 9 |
of the immune | 9 |
and it is | 9 |
shown to reduce | 9 |
formation in the | 9 |
enzymatic activity of | 9 |
a disintegrin and | 9 |
with downregulated connexins | 9 |
pathological cardiac hypertrophy | 9 |
was detected in | 9 |
western blot analysis | 9 |
with increased ace | 9 |
a murine model | 9 |
is independent of | 9 |
volume and water | 9 |
change in the | 9 |
the solitary tract | 9 |
n virus infection | 9 |
captopril on mortality | 9 |
ii and at | 9 |
human airway epithelia | 9 |
a marker of | 9 |
european society of | 9 |
enzyme overexpression in | 9 |
were stained with | 9 |
potential role in | 9 |
and that the | 9 |
decreased ang ii | 9 |
by the spike | 9 |
have reported that | 9 |
epicardial adipose tissue | 9 |
is expected to | 9 |
renal blood flow | 9 |
treatment of cardiovascular | 9 |
cardiac hypertrophy is | 9 |
total rna was | 9 |
physiology and pathophysiology | 9 |
infection in the | 9 |
ang ii generation | 9 |
elucidation of the | 9 |
and healthy controls | 9 |
of the components | 9 |
ii levels and | 9 |
to regulate the | 9 |
the ras are | 9 |
against angiotensin ii | 9 |
into the circulation | 9 |
the hypotensive effect | 9 |
focus on the | 9 |
to be present | 9 |
of lung injury | 9 |
has emerged as | 9 |
is a zinc | 9 |
fold higher than | 9 |
atrial natriuretic peptide | 9 |
clinical features of | 9 |
the classical axis | 9 |
we have designed | 8 |
and renal disease | 8 |
systemic and local | 8 |
higher concentrations of | 8 |
studies have indicated | 8 |
of cardiovascular diseases | 8 |
diagnosis and treatment | 8 |
mrna expression profiling | 8 |
risk for covid | 8 |
such as ang | 8 |
s and s | 8 |
of the covid | 8 |
that administration of | 8 |
to determine whether | 8 |
type a receptor | 8 |
of circulating ace | 8 |
is important for | 8 |
of vasopressin from | 8 |
as bs type | 8 |
of the amino | 8 |
and enzymatic activity | 8 |
chinese center for | 8 |
infarction by blockade | 8 |
to the plasma | 8 |
the in vitro | 8 |
angiotensin system blockade | 8 |
is dependent on | 8 |
sex differences in | 8 |
in the covid | 8 |
studies in mice | 8 |
is the only | 8 |
reninangiotensin system in | 8 |
of pulmonary vascular | 8 |
we have previously | 8 |
axis has been | 8 |
ang iv and | 8 |
this study we | 8 |
function as a | 8 |
can induce the | 8 |
in the p | 8 |
added to the | 8 |
in normotensive and | 8 |
inhibition on angiotensin | 8 |
to be effective | 8 |
on mortality in | 8 |
and viral replication | 8 |
discovery of a | 8 |
cardiac phenotype in | 8 |
ace in cardiovascular | 8 |
and stored at | 8 |
hydrolysis of ang | 8 |
than those of | 8 |
associated with severe | 8 |
in lung diseases | 8 |
integrity of the | 8 |
linked to viral | 8 |
the concept that | 8 |
treated with the | 8 |
been demonstrated that | 8 |
epidermal growth factor | 8 |
effect of bradykinin | 8 |
and it was | 8 |
enzymes and receptors | 8 |
aceis and arbs | 8 |
randomized controlled trials | 8 |
but not by | 8 |
infected with novel | 8 |
nlrp inflammasome in | 8 |
may explain the | 8 |
samples were collected | 8 |
the potential of | 8 |
use of these | 8 |
in many tissues | 8 |
it should be | 8 |
into host cells | 8 |
novel coronavirus pneumonia | 8 |
kidney and testis | 8 |
known that the | 8 |
ace mrna levels | 8 |
the acute phase | 8 |
injury induced by | 8 |
of ras blockade | 8 |
in ace gene | 8 |
at receptor blocker | 8 |
the responses to | 8 |
reduced in the | 8 |
through binding to | 8 |
were obtained from | 8 |
cardiac dysfunction and | 8 |
deficiency is associated | 8 |
nitric oxide release | 8 |
a new target | 8 |
endoplasmic reticulum stress | 8 |
of severe cases | 8 |
of components of | 8 |
the two peptides | 8 |
myocardial infarction by | 8 |
levels were measured | 8 |
action of the | 8 |
the apical surface | 8 |
and cardiac dysfunction | 8 |
in the process | 8 |
renin and angiotensinogen | 8 |
the search for | 8 |
inhibitors or arbs | 8 |
heart function angiotensin | 8 |
because of the | 8 |
a potent vasoconstrictor | 8 |
with angiotensin ii | 8 |
altered blood pressure | 8 |
pathogenic avian influenza | 8 |
of the cells | 8 |
and endothelial cells | 8 |
reduction of ang | 8 |
angiotensin i and | 8 |
in support of | 8 |
of this receptor | 8 |
than ang ii | 8 |
were compared with | 8 |
model of hypertension | 8 |
the alternative raas | 8 |
show that the | 8 |
type i receptor | 8 |
in adipose tissue | 8 |
infected patients linked | 8 |
explained by the | 8 |
silva et al | 8 |
of both ace | 8 |
neutral amino acids | 8 |
is inhibited by | 8 |
not have any | 8 |
been described in | 8 |
the protective arm | 8 |
to the synthesis | 8 |
and its metabolites | 8 |
appear to be | 8 |
peptides and their | 8 |
with h n | 8 |
homologue ace and | 8 |
into the extracellular | 8 |
functional significance of | 8 |
studies of the | 8 |
approval of the | 8 |
with our previous | 8 |
the inflammatory response | 8 |
the lung tumor | 8 |
yet to be | 8 |
suggest that ang | 8 |
clinical trial of | 8 |
is a type | 8 |
with severe acute | 8 |
role in cardiovascular | 8 |
mas axis of | 8 |
tubular epithelial cells | 8 |
for cardiovascular diseases | 8 |
signal transduction mechanisms | 8 |
be induced by | 8 |