bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
acute respiratory	2778
respiratory distress	2497
distress syndrome	2331
intensive care	2263
lung injury	1938
mechanical ventilation	1856
critically ill	1496
septic shock	1117
care unit	1108
ill patients	1093
respiratory failure	989
acute lung	971
ards patients	827
critical care	598
risk factors	577
patients admitted	565
severe acute	542
icu admission	512
severe ards	507
organ failure	507
mg kg	505
control group	503
icu patients	475
pao fio	465
hospital mortality	463
mechanically ventilated	458
mortality rate	454
cardiac arrest	450
ml kg	446
tidal volume	442
two groups	440
prone positioning	421
apache ii	405
inflammatory response	391
membrane oxygenation	375
icu stay	373
extracorporeal membrane	369
significantly higher	361
stem cells	361
mean age	356
respiratory syndrome	343
observational study	342
coronavirus disease	340
ventilated patients	325
airway pressure	323
critical illness	317
severe sepsis	314
sofa score	309
care units	302
nitric oxide	301
induced lung	299
blood pressure	296
systematic review	294
day mortality	293
septic patients	293
blood flow	292
organ dysfunction	288
gas exchange	284
ali ards	283
cohort study	283
pulmonary edema	278
clinical trial	277
endothelial cells	275
pg ml	274
adult patients	273
clinical trials	272
statistically significant	268
cardiac surgery	267
ng ml	264
prone position	263
brain injury	260
university hospital	258
mesenchymal stem	255
cardiac output	252
arterial blood	250
significant difference	248
retrospective study	248
arterial pressure	246
ii score	243
study period	240
novel coronavirus	240
present study	238
ethics regulations	238
driving pressure	235
expiratory pressure	231
multiple organ	230
controlled trial	228
significant differences	227
cord uid	227
renal failure	227
doc id	227
positive end	223
logistic regression	222
prospective study	221
severe covid	221
adult respiratory	221
pulmonary vascular	216
body weight	215
extracellular vesicles	214
randomized controlled	213
icu mortality	212
fio ratio	205
renal replacement	203
multivariate analysis	200
spontaneous breathing	200
informed consent	199
patients received	199
immune response	199
central venous	198
patients treated	198
factors associated	198
respiratory rate	197
epithelial cells	196
patients undergoing	195
tidal volumes	194
blood samples	193
heart rate	192
associated pneumonia	191
patients receiving	191
patients without	190
replacement therapy	190
risk factor	190
growth factor	189
emergency department	188
respiratory system	188
respiratory tract	187
berlin definition	186
type ii	185
necrosis factor	183
pulmonary artery	183
kidney injury	182
acute kidney	179
statistical analysis	179
cytokine storm	178
saps ii	177
care medicine	177
endothelial cell	176
gene expression	175
hospital stay	174
clinical practice	172
stem cell	170
animal models	170
blood gas	170
mean arterial	169
inflammatory cytokines	168
high mortality	167
invasive mechanical	167
tumor necrosis	166
lung tissue	165
mortality rates	165
disease severity	164
years old	164
higher mortality	164
high risk	163
among patients	162
median age	162
clinical characteristics	161
trauma patients	160
included patients	159
one patient	159
bronchoalveolar lavage	158
antibiotic therapy	158
virus infection	157
increased mortality	157
heart failure	156
two patients	154
performed using	153
protective ventilation	152
significantly lower	152
traumatic brain	151
adverse events	150
oxygen saturation	150
hospital discharge	149
invasive ventilation	148
immune system	147
lung disease	147
increased risk	147
plateau pressure	146
clinical course	145
diffuse alveolar	142
clinical outcomes	140
vascular permeability	140
icu discharge	139
mg dl	138
acute phase	137
pulmonary hypertension	137
respiratory mechanics	136
first hours	135
inclusion criteria	135
regression analysis	135
syndrome coronavirus	134
consecutive patients	133
alveolar damage	133
within hours	133
signifi cant	133
poor outcome	133
alveolar epithelial	133
primary outcome	133
may also	132
mm hg	132
induced ards	132
prospective observational	131
life support	131
first days	131
signifi cantly	131
reactive protein	131
cardiac index	131
bone marrow	129
data suggest	128
independently associated	128
significant increase	127
cell types	127
plasma levels	127
hospitalized patients	125
acquired pneumonia	125
inflammatory mediators	125
vascular resistance	124
patients died	124
significantly increased	124
lower respiratory	123
related ards	123
ventilatory support	122
univariate analysis	122
pressure support	121
low tidal	121
fi rst	120
converting enzyme	119
clinical features	119
free days	119
clinical studies	119
pulmonary embolism	118
important role	117
previous studies	117
myocardial infarction	117
pulmonary fibrosis	116
least one	115
lung inflammation	115
blood gases	115
cardiogenic shock	114
left ventricular	114
immune cells	113
controlled trials	113
ethics committee	113
peripheral blood	113
induced acute	113
shock patients	113
severe respiratory	112
lung function	112
respiratory syncytial	112
lung compliance	112
survival rate	111
ct scan	111
lactate levels	110
ml min	110
kg min	110
oxygen therapy	110
surgical patients	110
long term	110
lung recruitment	110
syncytial virus	109
acute renal	109
pulmonary disease	109
oxidative stress	109
side effects	108
patients requiring	108
systemic inflammatory	108
month period	108
group i	107
odds ratio	107
clinical data	107
carbon dioxide	106
endotracheal tube	105
influenza virus	105
interquartile range	104
right ventricular	104
viral infection	104
significantly associated	103
nosocomial infections	103
confidence interval	103
systemic inflammation	102
icu length	102
pilot study	102
patients hospitalized	102
alveolar macrophages	101
three patients	101
high levels	101
significantly reduced	101
vascular endothelial	101
hypoxemic respiratory	101
sample size	101
year period	101
pseudomonas aeruginosa	100
endothelial barrier	100
dead space	100
plasminogen activator	100
united states	99
lung biopsy	99
severe disease	99
significantly different	98
data collection	98
computed tomography	98
neutrophil extracellular	98
exclusion criteria	98
prospective cohort	98
obese patients	98
randomized clinical	97
within days	97
respiratory support	97
healthy controls	97
predictive value	96
retrospective analysis	96
retrospective cohort	96
case series	95
ventilator settings	95
tfr cells	94
hospital admission	94
pediatric intensive	94
lung ultrasound	94
partial pressure	94
ex vivo	93
corticosteroid therapy	93
renal function	93
acute pancreatitis	93
hospital cardiac	93
viral infections	92
serum levels	91
open lung	91
poor prognosis	90
fl uid	90
cytokine release	90
failure assessment	90
demographic data	89
ards group	89
noninvasive ventilation	89
corticosteroid treatment	89
independent risk	88
beneficial effects	88
statistical significance	88
randomised controlled	88
hemorrhagic shock	88
pulmonary surfactant	88
glasgow coma	87
cell death	87
results suggest	87
study group	86
standard deviation	86
type i	86
platelet count	85
ecmo support	85
four patients	85
cell surface	85
treg cells	85
flow cytometry	85
acute physiology	85
lung volume	85
th day	84
pulmonary function	84
pediatric patients	83
severe hypoxemia	83
neurological outcome	83
patients included	83
health care	83
significant correlation	83
clinical outcome	83
pulmonary arterial	83
measured using	83
five patients	83
blood glucose	82
overall mortality	82
extracellular traps	82
patients suffering	82
significant decrease	82
innate immune	82
whole blood	82
protective effect	81
healthy volunteers	81
additional file	81
requiring mechanical	80
clinical signs	80
medical icu	80
age years	80
case report	80
inhaled nitric	80
inflammatory responses	80
cytokine production	80
infected patients	79
lavage fluid	79
adhesion molecules	79
recent study	79
mouse model	79
endotracheal intubation	79
proinflammatory cytokines	79
blood loss	79
may contribute	79
parenteral nutrition	78
positive airway	78
fluid responsiveness	78
stroke volume	78
liver transplantation	78
red blood	78
lung protective	78
hemodynamic parameters	78
heart disease	77
inspired oxygen	77
barrier function	77
higher risk	77
diff erence	77
surfactant protein	77
surgical icu	77
commonly used	77
sequential organ	77
oxygen consumption	76
may lead	76
staphylococcus aureus	76
disseminated intravascular	76
prognostic factors	76
chest ct	75
coronary artery	75
primary endpoint	75
response syndrome	75
chronic obstructive	74
care med	74
ejection fraction	74
fluid balance	74
per day	74
intravascular coagulation	74
enteral nutrition	74
exogenous surfactant	74
influenza pneumonia	74
reactive oxygen	73
several studies	73
oxygen delivery	73
average age	73
alveolar type	73
nlrp inflammasome	73
recent studies	73
collected data	72
care patients	72
lung diseases	72
determine whether	72
patients infected	72
severity score	72
cardiopulmonary bypass	72
venous blood	72
three groups	72
data analysis	71
controlled ventilation	71
mg ml	71
adverse effects	71
surface area	71
obstructive pulmonary	71
regression model	71
angiotensin ii	71
randomized trial	71
severe pneumonia	71
six patients	71
median time	71
significantly decreased	70
current study	70
blood cultures	70
extracorporeal life	70
immune responses	70
baseline characteristics	70
arterial oxygen	70
seven patients	70
intubated patients	69
study included	69
analysis showed	69
elderly patients	69
acute hypoxemic	69
consensus conference	69
flow nasal	69
significant reduction	69
esophageal pressure	69
reperfusion injury	69
receiver operating	69
glucocorticoid receptor	68
blood cell	68
nosocomial infection	68
postoperative period	68
high dose	68
host defense	68
patients showed	68
supine position	68
lower tidal	68
patients will	68
diff erent	68
bacterial pneumonia	68
patients underwent	67
analyzed using	67
acute myocardial	67
study conducted	67
chest radiograph	66
eff ect	66
host response	66
blood transfusion	66
cardiopulmonary resuscitation	65
volume ventilation	65
ii cells	65
body mass	65
per patient	65
lung perfusion	65
blood cells	65
patient data	65
study showed	65
severity scores	65
viral pneumonia	65
group ii	65
without ards	65
linear regression	65
intracranial pressure	65
cd cd	64
liver failure	64
mesenchymal stromal	64
minute ventilation	64
kg day	64
adhesion molecule	64
patients developed	64
enteral feeding	64
widely used	64
ards may	64
nervous system	63
cell proliferation	63
pulmonary inflammation	63
prognostic value	63
cancer patients	63
may improve	63
hospital length	63
bacterial infection	63
kidney disease	63
neuromuscular blockade	63
patients may	63
lung mechanics	62
nasal cannula	62
patients required	62
protective effects	62
time points	62
differentially expressed	62
cmv reactivation	62
head injury	62
beneficial effect	61
individual patient	61
mean duration	61
venous pressure	61
brain death	61
blood culture	61
oleic acid	61
viral load	61
co removal	61
skeletal muscle	61
inspiratory pressure	61
lung water	61
exact test	61
injured lungs	61
secondary outcomes	61
tfr treg	61
severe cases	61
medical intensive	60
authors declare	60
release ventilation	60
inflammasome activation	60
medical records	60
transpulmonary pressure	60
chest wall	60
leading cause	60
pressure release	60
alveolar space	60
ascorbic acid	60
system compliance	60
pandemic influenza	60
serum creatinine	60
surface tension	60
deep sedation	60
year mortality	60
lung epithelial	60
pressure ventilation	60
world health	60
risk patients	59
ischemic stroke	59
patients aged	59
mortality among	59
ventilation strategy	59
cell type	59
dendritic cells	59
stimulating factor	59
increased significantly	59
mass index	59
venous catheter	59
lung cancer	58
author funder	58
hemodynamic instability	58
granted medrxiv	58
lung damage	58
fatty acids	58
rescue therapy	58
predicted body	58
nutritional support	58
one hundred	58
patients presenting	58
roc curve	58
inflammatory cytokine	57
tertiary care	57
jugular vein	57
associated ards	57
teaching hospital	57
cardiac function	57
copyright holder	57
tissue damage	57
oxygen species	57
continuous infusion	57
herpes simplex	57
median duration	57
peep levels	57
east respiratory	57
early diagnosis	57
one case	56
time course	56
clinical study	56
multicenter study	56
circulatory failure	56
sex ratio	56
plasma concentrations	56
abdominal surgery	56
public health	56
middle east	56
fluid clearance	56
tracheal intubation	56
early phase	56
animal model	56
european consensus	56
study aimed	56
potential therapeutic	56
burn patients	55
fluid resuscitation	55
mononuclear cells	55
inflammatory lung	55
barrier dysfunction	55
eight patients	55
human lung	55
induced ali	55
endothelial permeability	55
mortality risk	55
previously described	55
pulmonary oedema	55
severe trauma	55
lpv cds	55
organ donation	55
induced pulmonary	55
multiple trauma	54
may result	54
health organization	54
chain reaction	54
gas analysis	54
retrospective observational	54
recruitment maneuver	54
support ventilation	54
placebo group	54
refractory hypoxemia	54
lung parenchyma	54
normal range	54
positive pressure	54
major surgery	54
nine patients	54
observational studies	54
polymerase chain	54
interstitial pneumonia	54
increased levels	54
treatment group	54
preliminary results	54
international congresses	54
ischemia reperfusion	54
injury severity	54
gram negative	53
phase ii	53
burn injury	53
may help	53
european society	53
prolonged mechanical	53
patient outcomes	53
data collected	53
three days	53
developed ards	53
stromal cells	53
flow rate	53
nursing staff	53
term mortality	53
surviving sepsis	53
smooth muscle	53
copd patients	53
study population	52
version posted	52
intracranial hypertension	52
cytokine levels	52
eff ects	52
cds tool	52
may play	52
animal studies	52
previously reported	52
assessed using	52
diabetes mellitus	52
operating characteristic	52
first day	52
progenitor cells	52
tract infection	52
artery catheter	52
continuous variables	52
monoclonal antibody	52
pulmonary infection	51
elevated levels	51
coma scale	51
wound healing	51
blood lactate	51
ill adults	51
spontaneously breathing	51
general hospital	51
endothelial dysfunction	51
dornase alfa	51
days later	51
predictive factors	51
treated patients	51
simplex virus	51
organ system	51
high frequency	51
endothelial growth	50
medical center	50
recent years	50
respiratory disease	50
well tolerated	50
icu admissions	50
general anesthesia	50
surfactant system	50
pleural effusion	50
high peep	50
cell count	50
single center	50
patients compared	50
high doses	50
binding protein	50
like receptor	50
two different	50
ten patients	50
clinical presentation	50
adipose tissue	50
patient care	50
reduce mortality	50
mitochondrial dna	50
investigate whether	49
sofa scores	49
patient population	49
scoring system	49
lung tissues	49
room temperature	49
chest radiography	49
liver function	49
patient safety	49
post hoc	49
two cases	49
high incidence	49
compared using	49
antibiotic treatment	49
mean apache	49
mean values	49
clinical manifestations	49
required mechanical	49
term outcomes	49
innate immunity	49
alveolar fluid	49
major cause	49
may reduce	49
sepsis campaign	49
oxygenation index	49
patients presented	48
even though	48
healthy subjects	48
ventilation strategies	48
recruitment maneuvers	48
every hours	48
experimental studies	48
central nervous	48
lung edema	48
activated protein	48
control patients	48
last years	48
interstitial lung	48
early stage	48
supplementary material	48
significant improvement	48
chronic health	48
oscillatory ventilation	48
patient characteristics	48
made available	48
lung regions	48
mechanical power	48
respiratory infection	47
per year	47
clinically relevant	47
family members	47
rat model	47
physiology score	47
mean airway	47
atrial fibrillation	47
multivariate logistic	47
descriptive study	47
ml cmh	47
one year	47
common cause	47
ii scores	47
identifi ed	47
hazard ratio	47
epithelial cell	47
white blood	47
like syndrome	47
emergency room	47
considered statistically	47
showed significant	47
impedance tomography	47
higher levels	47
ill children	47
pediatric ards	47
may provide	47
square test	47
infected mice	46
medical history	46
lps stimulation	46
associated acute	46
amino acid	46
chest radiographs	46
tissue injury	46
study protocol	46
protein kinase	46
simplified acute	46
defi ned	46
independent predictor	46
oxide synthase	46
airway pressures	46
results indicate	46
symptom onset	46
lower mortality	46
surgery patients	46
disease progression	46
cardiac failure	46
severe patients	46
intervention group	46
body temperature	46
diff erences	46
influenza infection	46
high morbidity	46
therapeutic hypothermia	46
negative bacteria	46
rheumatoid arthritis	46
observational cohort	45
one study	45
molecular weight	45
infectious diseases	45
decision making	45
cause mortality	45
blood volume	45
remains neutral	45
barrier integrity	45
study design	45
published maps	45
acinetobacter baumannii	45
hoc analysis	45
lung fibrosis	45
prospectively collected	45
niv failure	45
springer nature	45
crit care	45
randomly assigned	45
significant changes	45
frequency oscillatory	45
antimicrobial therapy	45
systolic blood	45
jurisdictional claims	45
functional status	45
institutional affiliations	45
neuromuscular blocking	45
gene therapy	45
standard care	45
right ventricle	45
fl ow	45
nature remains	45
extubation failure	45
systolic function	45
moderate ards	45
study including	44
selected patients	44
therapeutic potential	44
bal fluid	44
findings suggest	44
first week	44
monoclonal antibodies	44
written informed	44
inflammatory cells	44
per minute	44
respiratory infections	44
clinical research	44
cell membrane	44
improve survival	44
health evaluation	44
gold standard	44
right heart	44
improved survival	44
extravascular lung	44
results show	44
airway management	44
one hour	44
med doi	44
significant association	44
propensity score	44
peak inspiratory	44
results showed	44
peer review	44
convalescent plasma	44
electrical impedance	43
respiratory viruses	43
also found	43
pneumoniae pneumonia	43
ards due	43
release syndrome	43
review board	43
early acute	43
traditional tidal	43
endothelial injury	43
studied patients	43
signaling pathway	43
creatinine clearance	43
improve oxygenation	43
immune cell	43
supportive care	43
severely ill	43
ecmo initiation	43
alveolar recruitment	43
underlying disease	43
glass opacities	43
critical patients	43
cell therapy	43
severe influenza	43
neuromuscular blockers	43
chronic kidney	43
normal saline	43
enrolled patients	42
alveolar edema	42
categorical variables	42
higher peep	42
ang ii	42
berlin criteria	42
icu los	42
randomized trials	42
higher incidence	42
ill patient	42
fluid administration	42
significantly improved	42
new zealand	42
well known	42
group compared	42
first time	42
groups according	42
inflammatory diseases	42
control groups	42
escherichia coli	42
endothelial damage	42
tissue oxygenation	42
subgroup analysis	42
patients using	42
hyaline membrane	42
study demonstrated	42
vena cava	41
space fraction	41
pulmonary endothelial	41
signaling pathways	41
prospective randomized	41
future studies	41
congenital heart	41
amino acids	41
dimer levels	41
acute brain	41
liver disease	41
ecmo therapy	41
may cause	41
igg liposomes	41
strongly associated	41
respiratory symptoms	41
dysfunction syndrome	41
significantly elevated	41
body surface	41
activator inhibitor	41
fluid management	41
metabolic acidosis	41
major trauma	41
short term	41
ill covid	41
table shows	41
organ damage	41
total number	41
two hours	41
older patients	41
included studies	41
decreased significantly	41
muscle weakness	41
mycoplasma pneumoniae	41
internal jugular	41
expiratory flow	40
blocking agents	40
severe traumatic	40
hand hygiene	40
fluid challenge	40
receptor antagonist	40
phase i	40
high level	40
two studies	40
remains unclear	40
determined using	40
early detection	40
fatty acid	40
another study	40
fluid overload	40
alveolar epithelium	40
control study	40
data will	40
real time	40
high flow	40
nuclear factor	40
severe head	40
diagnostic criteria	40
recombinant human	40
cant diff	40
study will	40
key role	40
hyaline membranes	40
major role	40
group showed	40
organ failures	40
sepsis syndrome	40
bal samples	40
infectious complications	40
lactate level	39
acute onset	39
injured lung	39
intravenous infusion	39
regression models	39
may increase	39
identify patients	39
therapeutic strategies	39
cov infections	39
failure due	39
median length	39
derived mesenchymal	39
artery bypass	39
time point	39
transcription factor	39
may explain	39
clinical management	39
molecular mechanisms	39
also observed	39
including patients	39
three different	39
controlled study	39
renal dysfunction	39
inflammatory process	38
lps group	38
time period	38
positive correlation	38
neutrophil elastase	38
knockout mice	38
receiving mechanical	38
data regarding	38
medical care	38
continuous renal	38
surgical intensive	38
considered significant	38
association studies	38
pulmonary microvascular	38
coronavirus pneumonia	38
cox regression	38
blood products	38
therapeutic effects	38
arterial oxygenation	38
confidence intervals	38
may occur	38
injured patients	38
eff ective	38
case reports	38
acute exacerbation	38
edema fluid	38
significantly correlated	38
drug administration	38
previous study	38
task force	38
lung transplantation	38
peep cmh	38
urine output	38
large number	38
success rate	38
derived exosomes	38
fibrin deposition	38
systemic vascular	38
small sample	37
mcg kg	37
organizing pneumonia	37
positive blood	37
lung collapse	37
avian influenza	37
rsv infection	37
ec barrier	37
mrna expression	37
inflamed lungs	37
hong kong	37
therapeutic intervention	37
care doi	37
defense mechanisms	37
institutional review	37
cov infection	37
continuous positive	37
year old	37
immunocompromised patients	37
calculated using	37
steady state	37
receive either	37
first three	37
patients diagnosed	37
bacterial infections	37
fi ndings	37
cecal ligation	37
derived evs	37
idiopathic pulmonary	37
mean value	37
relative risk	37
acute pulmonary	37
multiorgan failure	37
icu survivors	37
mitochondrial dysfunction	36
venous thromboembolism	36
hours later	36
united kingdom	36
rights reserved	36
international license	36
preliminary data	36
icu nurses	36
cardiac dysfunction	36
failure requiring	36
breathing trial	36
data indicate	36
blood vessels	36
heart surgery	36
care physicians	36
blood mononuclear	36
mixed venous	36
organ injury	36
end expiratory	36
perfusion pressure	36
least days	36
successful weaning	36
conventional ventilation	36
rank test	36
supplementary table	36
see table	36
respiratory insufficiency	36
conventional mechanical	36
pulse oximetry	36
ards caused	36
head trauma	36
tissue factor	36
controlled clinical	36
severe lung	36
secondary infections	36
hydrogen peroxide	36
center study	36
competing interests	36
protein levels	36
coronavirus infection	36
organ support	36
hepatocellular carcinoma	36
lung surfactant	36
mortality benefit	36
syndrome acute	36
previous reports	36
cardiogenic pulmonary	36
jugular bulb	36
cerebral perfusion	36
cardiac injury	35
volume expansion	35
bilateral infiltrates	35
different phenotypes	35
bacterial sepsis	35
note springer	35
whitney test	35
prospectively studied	35
clinical evidence	35
frequently used	35
status epilepticus	35
hospital day	35
well established	35
statistical analyses	35
intravenous administration	35
days post	35
surgical procedures	35
low levels	35
sepsis patients	35
final manuscript	35
inflammatory markers	35
routine use	35
homeostatic corrections	35
chronic respiratory	35
infl ammatory	35
urinary tract	35
systemic circulation	35
died within	35
normal lung	35
improved oxygenation	35
sars patients	35
klebsiella pneumoniae	35
immune function	35
high prevalence	35
surface markers	35
control subjects	35
extracellular vesicle	35
alveolar macrophage	34
eligible patients	34
traumatic stress	34
vascular leakage	34
spontaneous circulation	34
related complications	34
early identification	34
intercellular adhesion	34
commercially available	34
reduced mortality	34
pulmonary infiltrates	34
following parameters	34
poor outcomes	34
thoracic society	34
patients survived	34
awake proning	34
disease control	34
supplemental oxygen	34
general icu	34
human lungs	34
thermal injury	34
three times	34
peak airway	34
inflammatory effects	34
burned patients	34
demographic characteristics	34
pivotal role	34
also showed	34
hemodynamic monitoring	34
willebrand factor	34
heat shock	34
patients enrolled	34
cognitive dysfunction	34
energy expenditure	34
negative predictive	34
coma score	34
stress disorder	34
aspiration pneumonia	34
expression levels	34
study shows	34
weaning failure	34
studies suggest	34
endothelial glycocalyx	33
term outcome	33
scientific studies	33
injury induced	33
free radicals	33
independent predictors	33
normal values	33
preterm infants	33
experimental study	33
fish oil	33
inflammatory processes	33
cystic fibrosis	33
respiratory function	33
pulmonary blood	33
operating room	33
studies showed	33
ii pneumocytes	33
following trauma	33
healthy control	33
differ significantly	33
experimental model	33
growth factors	33
nosocomial pneumonia	33
therapeutic interventions	33
patient died	33
stromal cell	33
medrxiv preprint	33
randomized study	33
associated lung	33
portal vein	33
infl ammation	33
ventilation mode	33
central role	33
correlation coefficient	33
pulmonary vasoconstriction	33
vascular endothelium	33
antiviral therapy	33
differential diagnosis	33
human mesenchymal	33
primary objective	33
postoperative complications	33
lps administration	33
secondary analysis	33
ventricular function	33
increased morbidity	33
pulse pressure	33
subarachnoid hemorrhage	33
positive predictive	33
von willebrand	33
general population	33
patient outcome	33
influenza viruses	33
dependent lung	33
acute care	33
transforming growth	33
patients ventilated	33
adverse event	33
study aims	33
injury score	33
arterial lactate	33
ards cases	33
longer duration	33
common risk	33
survival rates	33
peep level	33
sars coronavirus	32
hospital death	32
acquired weakness	32
congestive heart	32
pulmonary dysfunction	32
lactate dehydrogenase	32
days vs	32
wide range	32
lung endothelial	32
days following	32
murine model	32
severe form	32
therapeutic strategy	32
analysis revealed	32
previously healthy	32
apache iii	32
static compliance	32
mild disease	32
vivo lung	32
abdominal muscle	32
ards model	32
factor alpha	32
patienten mit	32
vital signs	32
complement activation	32
trend towards	32
hospital survivors	32
low dose	32
surfactant replacement	32
study performed	32
glucocorticoid treatment	32
artery pressure	32
lung microbiome	32
lps challenge	32
way anova	32
organ function	32
ventilator associated	32
disease process	32
bacterial translocation	32
blood sample	32
ards severity	32
tnf production	32
treatment strategies	32
barrier enhancement	32
increased vascular	32
adult icu	32
cardiovascular disease	31
kg body	31
abdominal sepsis	31
better understanding	31
healthcare workers	31
chronic renal	31
brain tissue	31
early recognition	31
right lung	31
clinical decision	31
macrophage activation	31
laboratory data	31
study suggests	31
different respiratory	31
research support	31
control animals	31
old male	31
wistar rats	31
medical university	31
alveolar surfactant	31
statistically signifi	31
molecular patterns	31
cerebral blood	31
upper respiratory	31
practice guidelines	31
functional outcome	31
blood vessel	31
two independent	31
improves oxygenation	31
lung ventilation	31
tertiary hospital	31
extracorporeal co	31
surfactant function	31
initial dose	31
support scientific	31
admitted patients	31
non invasive	31
pathological findings	31
potential role	31
surfactant material	31
icu care	31
emergency medicine	31
culture medium	31
mean length	31
inotropic support	31
hepatic failure	31
brain damage	31
second group	31
worse outcomes	31
one week	30
clinical diagnosis	30
incidence rate	30
patients whose	30
serum concentrations	30
developing ards	30
increased pulmonary	30
studies using	30
taken together	30
also known	30
cell barrier	30
standard treatment	30
organ systems	30
injury acute	30
outcome measures	30
negative correlation	30
children admitted	30
edema formation	30
therapeutic target	30
alveolar lavage	30
oxygen tension	30
plasma samples	30
room air	30
treated group	30
outcome data	30
mechanical ventilator	30
cell injury	30
respiratory parameters	30
alveolar hemorrhage	30
septic complications	30
may benefit	30
ct scans	30
ards network	30
high rate	30
assess whether	30
hypoxic pulmonary	30
new therapeutic	30
significant morbidity	30
pulmonary injury	30
clinical severity	30
patient groups	30
platelet counts	30
platelet activation	30
assisted ventilation	30
lung involvement	30
vasoactive drugs	30
severe adult	30
american thoracic	30
acute circulatory	30
sensitivity analysis	30
residual capacity	30
functional residual	30
associated molecular	30
seven days	30
angiotensin converting	30
lung weight	30
transcription factors	30
early stages	30
transpulmonary thermodilution	30
target genes	30
type diabetes	30
mechanical stretch	30
also increased	30
main cause	30
dependent manner	30
clinical condition	30
identify factors	30
lipid peroxidation	30
muscle cells	30
fio mmhg	30
transthoracic echocardiography	30
gene transfer	30
flow oxygen	30
clinical setting	30
analysed using	29
mild ards	29
broad spectrum	29
tissue oxygen	29
venovenous ecmo	29
epithelial injury	29
therapeutic approach	29
map mmhg	29
immune dysfunction	29
dr expression	29
single dose	29
ventilatory management	29
acute inflammation	29
gestational age	29
class ii	29
different types	29
treatment options	29
therapeutic targets	29
membrane formation	29
tract infections	29
excluded patients	29
high concentrations	29
acute inflammatory	29
light chain	29
signal transduction	29
less severe	29
weaning process	29
drug delivery	29
good outcome	29
inspiratory time	29
respiratory drive	29
alveolar spaces	29
vitro studies	29
syndrome patients	29
adaptive immune	29
studies reported	29
evaluated using	29
many patients	29
negative pressure	29
myocardial injury	29
medical staff	29
myosin light	29
function tests	29
evaluate whether	29
undergoing cardiac	29
small number	29
loading dose	29
present case	29
new york	29
serum lactate	29
lymphocyte count	29
prothrombin time	29
time spent	29
severe pulmonary	29
rbc transfusion	29
cell activation	29
muscle mass	29
effective treatment	29
pulmonary circulation	29
clinical conditions	29
evidence suggests	29
unfavorable outcome	29
older age	29
inflammatory reaction	29
mean difference	29
fold increase	29
analysis using	28
mortality compared	28
quality improvement	28
study found	28
release phase	28
hospital survival	28
decreased mortality	28
much higher	28
arterial ph	28
per se	28
authors read	28
protective mechanical	28
acute coronary	28
vascular dysfunction	28
mortality associated	28
severe forms	28
colony stimulating	28
severe tbi	28
traumatic injury	28
published data	28
therapeutic effect	28
sodium transport	28
critical role	28
cell transplantation	28
observation period	28
venous thrombosis	28
among critically	28
unit patients	28
trial coordination	28
protein expression	28
regional lung	28
ace expression	28
respiratory acidosis	28
vascular barrier	28
plasma il	28
gas flow	28
confirmed covid	28
ards mice	28
venovenous extracorporeal	28
primary cause	28
therapeutic options	28
ecmo patients	28
every patient	28
requiring icu	28
serious adverse	28
clinical use	28
inflammatory effect	28
discharged alive	28
emergency medical	28
relevant outcomes	28
probably due	28
iu ml	28
glasgow outcome	28
monocentric study	28
average time	28
apache score	28
oxygen extraction	28
laboratory findings	28
survival benefit	28
icu beds	28
confi rmed	28
left atrial	28
fluid therapy	28
ivc diameter	28
scoring systems	28
clinical significance	28
kg predicted	28
infection control	28
data obtained	28
retrospective review	28
medical patients	28
underlying diseases	28
hypoxic respiratory	28
cell line	28
altman analysis	28
hypoxemic patients	28
bed icu	27
life care	27
phase iii	27
hemodynamic effects	27
total body	27
fatal outcome	27
connective tissue	27
may influence	27
surfactant abnormalities	27
inferior vena	27
secondary endpoints	27
significantly longer	27
study clinical	27
myocardial ischemia	27
capillary barrier	27
early sepsis	27
closely related	27
will also	27
aged years	27
adjunctive therapy	27
therapeutic management	27
receptor expression	27
organ dysfunctions	27
novel therapeutic	27
related acute	27
ventricular failure	27
cohort studies	27
plasma concentration	27
pulmonary capillary	27
fatality rate	27
lymph nodes	27
bronchopulmonary dysplasia	27
several factors	27
ventilation perfusion	27
similar results	27
mean time	27
ml vs	27
corresponding author	27
angiotensin system	27
porcine model	27
infected pneumonia	27
surfactant administration	27
internal medicine	27
unfractionated heparin	27
different levels	27
protein synthesis	27
prognostic factor	27
partial thromboplastin	27
ards according	27
sublingual microcirculation	27
lining fluid	27
corticosteroid use	27
month follow	27
extracellular matrix	27
chronic lung	27
nmba infusion	27
previously published	27
acute liver	27
diaphragm dysfunction	27
within minutes	27
many studies	27
one patients	27
hepatic encephalopathy	27
surgical intervention	27
cell apoptosis	27
group versus	27
overall survival	27
available data	27
hours following	27
severe complications	27
abdominal pain	27
prone ventilation	27
capillary permeability	26
retrospectively reviewed	26
hours post	26
respiratory viral	26
without significant	26
age group	26
requiring intensive	26
venous oxygen	26
remaining patients	26
peep titration	26
respiratory diseases	26
icu treatment	26
ventilation distribution	26
diagnostic accuracy	26
recently published	26
mean sd	26
combination therapy	26
alveolar collapse	26
four groups	26
less likely	26
significantly greater	26
mean blood	26
seb veh	26
high tidal	26
baseline values	26
pulmonary dead	26
two years	26
oxygen radicals	26
cell function	26
remained unchanged	26
whole body	26
severe illness	26
thrombin generation	26
kg pbw	26
breathing pattern	26
perfusion mismatch	26
left ventricle	26
twenty patients	26
cirrhotic patients	26
year survival	26
identify risk	26
vascular injury	26
clinical parameters	26
based therapies	26
birth weight	26
dawley rats	26
spotted fever	26
new insights	26
clinical examination	26
improves survival	26
kg hr	26
secondary bacterial	26
syndrome associated	26
cure rct	26
cardiac surgical	26
may represent	26
per group	26
higher apache	26
variables associated	26
natriuretic peptide	26
cantly higher	26
improve patient	26
induced inflammation	26
medical treatment	26
authors concluded	26
clinical improvement	26
mg day	26
study groups	26
ml cm	26
cell therapies	26
venous extracorporeal	26
systemic corticosteroids	26
group without	26
severe asthma	26
cell adhesion	26
international guidelines	26
blood levels	26
femoral vein	26
wedge pressure	26
nitrogen balance	26
community acquired	26
carotid artery	26
derived mscs	26
least hours	26
sum test	26
fungal infection	26
positive patients	26
study reported	26
day survival	26
patients needed	26
twice daily	26
lung infection	26
ulvwf path	25
hepatocyte growth	25
hospital icu	25
icu days	25
eolia trial	25
pediatric acute	25
transit time	25
pneumonia patients	25
vein thrombosis	25
emergency departments	25
transplant recipients	25
marginated neutrophils	25
chest pain	25
four hours	25
statistical difference	25
lung failure	25
therapeutic approaches	25
fungal infections	25
activated neutrophils	25
term survival	25
one third	25
early corticosteroid	25
lung morphology	25
granulocyte colony	25
animal experiments	25
remains controversial	25
control mice	25
treatment groups	25
working group	25
surgical procedure	25
disease course	25
dioxide removal	25
early postoperative	25
seb thc	25
ards patient	25
serum il	25
proinflammatory cytokine	25
antiviral treatment	25
mainly due	25
early treatment	25
viral replication	25
fi brinogen	25
inspiratory effort	25
care setting	25
expert opinion	25
critical ill	25
ground glass	25
viral rna	25
peritoneal macrophages	25
also recorded	25
critical covid	25
vascular leak	25
requiring invasive	25
negative bacilli	25
patients suffered	25
continuous monitoring	25
regional strain	25
vivo studies	25
surfactant therapy	25
healthy individuals	25
done using	25
may induce	25
drug resistant	25
two days	25
vt ml	25
tissue hypoxia	25
adrenal insufficiency	25
derived extracellular	25
single cell	25
tissue perfusion	25
higher rate	25
carbon monoxide	25
infl uenza	25
narrative review	25
consecutive days	25
superoxide dismutase	25
icu physicians	25
health problem	25
fiberoptic bronchoscopy	25
also associated	25
arterial hypertension	25
spontaneous ventilation	25
bloodstream infections	24
ct findings	24
premature infants	24
confirmed cases	24
neutropenic patients	24
ct imaging	24
cell counts	24
good correlation	24
mitochondrial function	24
predict mortality	24
late phase	24
invasive procedures	24
severe brain	24
selection bias	24
ards treatment	24
trend toward	24
differential expression	24
investigated whether	24
major abdominal	24
years ago	24
main causes	24
missing data	24
severe sars	24
several limitations	24
death among	24
least two	24
postoperative day	24
human immunodeficiency	24
keratinocyte growth	24
blood coagulation	24
respiratory effort	24
kg hour	24
significant proportion	24
data show	24
cortisol levels	24
american college	24
thromboplastin time	24
making process	24
bloodstream infection	24
liver cirrhosis	24
infectious disease	24
main results	24
clinical criteria	24
tyrosine kinase	24
nk cells	24
eff ectiveness	24
ventilatory strategy	24
prolonged icu	24
mean pulmonary	24
low molecular	24
streptococcus pneumoniae	24
factors related	24
donor lungs	24
fluid loading	24
france correspondence	24
deep vein	24
gastric contents	24
adverse outcomes	24
cytokine response	24
serum samples	24
early ards	24
immunodeficiency virus	24
resource utilization	24
related quality	24
chest compressions	24
hypercapnic acidosis	24
weaning protocol	24
immune suppression	24
first study	24
specific treatment	24
multivariate regression	24
syndrome clinical	24
inflammatory state	24
clinical findings	24
patients discharged	24
prospective studies	24
reference introduction	24
patients experienced	24
icu team	24
different clinical	23
roc curves	23
median sofa	23
improve outcomes	23
thrombocytopenic purpura	23
predict outcome	23
deceased patients	23
poor neurological	23
fi brosis	23
epidemiological characteristics	23
related organ	23
left lung	23
lung protection	23
breathing patients	23
typical acute	23
weight heparin	23
practice guideline	23
nutritional status	23
common complication	23
acute interstitial	23
negative impact	23
resistant bacteria	23
endothelial activation	23
develop ards	23
male patients	23
endothelial function	23
predict fluid	23
following criteria	23
microvascular endothelial	23
base excess	23
gastric emptying	23
two main	23
interim analysis	23
system failure	23
chi square	23
recruitment manoeuvre	23
human umbilical	23
oxygen supply	23
human monocytes	23
change significantly	23
venous return	23
study patients	23
oxygen fraction	23
thrombotic thrombocytopenic	23
group patients	23
endothelial progenitor	23
renal disease	23
respiratory treatments	23
ventilation time	23
massive transfusion	23
experimental models	23
ideal body	23
respiratory management	23
recently reported	23
umbilical cord	23
venous ecmo	23
tracheostomy tube	23
natural killer	23
ventricular dysfunction	23
plateau pressures	23
acinetobacter baumanii	23
patients developing	23
two methods	23
often associated	23
risk score	23
uric acid	23
crp levels	23
treated mice	23
artery disease	23
serum albumin	23
remains high	23
protective role	23
pulmonary syndrome	23
outcome scale	23
pk pd	23
patients met	23
neutrophil activation	23
invasive mv	23
syndrome prone	23
plasma exchange	23
one month	23
right atrial	23
ards mortality	23
increased permeability	23
median days	23
treatment failure	23
severe infections	23
data showed	23
prism score	23
gastrointestinal bleeding	23
lower risk	23
saps score	23
barrier regulation	23
neutrophil infiltration	23
secondary infection	23
immune dysregulation	23
injured mice	23
sepsis septic	23
spectrum antibiotics	23
venous catheters	23
wilcoxon rank	23
clinical experience	23
stroke patients	23
respiratory variations	23
femoral artery	23
chain kinase	23
lung recruitability	23
worse outcome	23
average duration	23
san diego	23
ards diagnosis	23
control ventilation	23
mobility group	23
expiratory time	23
vascular smooth	22
ventilatory parameters	22
filtration rate	22
ards induced	22
ecmo weaning	22
may allow	22
lopinavir ritonavir	22
candidate gene	22
prospective multicenter	22
interstitial edema	22
neurological complications	22
oxygenation parameters	22
cells may	22
physical examination	22
lung assist	22
total bilirubin	22
syndrome pulmonary	22
studies demonstrated	22
recent report	22
multicenter cohort	22
arrest patients	22
ii cell	22
ventricular ejection	22
might also	22
paediatric intensive	22
currently available	22
face mask	22
induced endothelial	22
per cent	22
dry weight	22
conventional ventilatory	22
patients also	22
volume index	22
also significantly	22
results demonstrate	22
first line	22
anticoagulant therapy	22
nursing care	22
mast cells	22
coronavirus infections	22
ct images	22
average length	22
antimicrobial resistance	22
different groups	22
vs control	22
neurologic outcome	22
hypertonic saline	22
infection due	22
icu patient	22
may reflect	22
independent factors	22
studies will	22
liver enzymes	22
microcirculatory blood	22
bacterial resistance	22
remains unknown	22
pulmonary compliance	22
extracorporeal circulation	22
chest tube	22
acute hypoxic	22
group will	22
intravenous injection	22
took place	22
lung pathology	22
electronic medical	22
i min	22
free radical	22
acute ischemic	22
upper airway	22
clinical suspicion	22
repeated measures	22
lung safe	22
standard practice	22
group iii	22
posted june	22
dynamic driving	22
negative sepsis	22
defined according	22
host immune	22
zu einer	22
blood transfusions	22
outcome measure	22
syndrome network	22
shockable rhythm	22
future research	22
first group	22
also noted	22
cor pulmonale	22
icu staff	22
hemodynamic stability	22
charlson comorbidity	22
nutrition support	22
bacterial growth	22
electron microscopy	22
complement system	22
pulmonary complications	22
patients within	22
care management	22
critical illnesses	22
illness severity	22
first step	22
time pcr	22
described previously	22
tbi patients	22
severe hypoxaemia	22
arachidonic acid	21
higher doses	21
results patients	21
volume resuscitation	21
clinical aspects	21
expressed genes	21
following injury	21
survival group	21
supplementary information	21
vital capacity	21
cerebrospinal fluid	21
old female	21
expression profiling	21
china clinical	21
ivig group	21
emergency surgery	21
every day	21
experimental data	21
chronic disease	21
intraperitoneal injection	21
multivariable analysis	21
vmtd dit	21
activating factor	21
appropriate treatment	21
ards remains	21
ventricular fibrillation	21
occlusion pressure	21
rank sum	21
clinical symptoms	21
ventilator asynchrony	21
kcal kg	21
young children	21
severe septic	21
infusion rate	21
controlled mode	21
life threatening	21
preclinical studies	21
invasive aspergillosis	21
hepatic dysfunction	21
common causes	21
thrombotic complications	21
neutrophil recruitment	21
frozen plasma	21
twelve patients	21
endotoxic shock	21
airway epithelial	21
pearson correlation	21
inhibitory effect	21
mortality due	21
physical function	21
citrate anticoagulation	21
lower incidence	21
qs qt	21
day post	21
machine learning	21
rat lung	21
pulmonary endothelium	21
primary end	21
comatose patients	21
cardiac arrests	21
ventilation management	21
cd cells	21
target range	21
liquid chromatography	21
past years	21
alcohol abuse	21
prolonged glucocorticoid	21
clinical impact	21
activated partial	21
factors may	21
insulin infusion	21
induced increase	21
following major	21
curve analysis	21
tracheal tube	21
ace receptor	21
dynamic compliance	21
group received	21
macrophage colony	21
gastrointestinal tract	21
improved outcomes	21
much lower	21
current practice	21
continuously monitored	21
metabolic disorders	21
lung elastance	21
low risk	21
days alive	21
received ecmo	21
secondary objectives	21
esophageal balloon	21
patients due	21
study also	21
clot formation	21
inflammatory reactions	21
lung aeration	21
patients develop	21
multiple sclerosis	21
elevated plasma	21
day period	21
tf path	21
respiratory compliance	21
sectional study	21
kg bw	21
elective surgery	21
diffi cult	21
extracorporeal lung	21
ards existence	21
emergency physicians	21
ganz catheter	21
significant change	21
require mechanical	21
nasal oxygen	21
patients following	21
refractory cardiac	21
surfactant proteins	21
early intervention	21
clinical status	21
acid aspiration	21
early use	20
physiological parameters	20
pulmonary gas	20
interventional group	20
serum level	20
myocardial dysfunction	20
cerebral oxygenation	20
one group	20
airway obstruction	20
epithelial barrier	20
imaging findings	20
first case	20
higher icu	20
significant impact	20
data meta	20
bypass grafting	20
undergoing elective	20
ventilator support	20
poorly understood	20
renal impairment	20
may develop	20
trial design	20
ill septic	20
bed medical	20
cognitive impairment	20
xanthine oxidase	20
severe coronavirus	20
induced apoptosis	20
prospectively included	20
electrical activity	20
health status	20
mechanisms underlying	20
hematopoietic stem	20
vessel density	20
preventive measures	20
bacterial meningitis	20
increased survival	20
diaphragm thickness	20
und der	20
data available	20
main reason	20
tissue samples	20
end point	20
french icus	20
low flow	20
acute severe	20
neurological outcomes	20
chart review	20
general intensive	20
early administration	20
white cell	20
analyses will	20
coagulation parameters	20
also performed	20
neonatal respiratory	20
viral loads	20
experimental sepsis	20
directed therapy	20
ethics approval	20
several clinical	20
infl uence	20
national health	20
first dose	20
laboratory parameters	20
mechanical stress	20
sb group	20
icu readmission	20
steroid therapy	20
two weeks	20
will help	20
often used	20
vascular tone	20
injury may	20
chronic pulmonary	20
gram positive	20
group box	20
lactic acidosis	20
variable ventilation	20
metabolic pathways	20
direct examination	20
local ethics	20
resistance index	20
cytokine filter	20
pulmonary pathology	20
potential benefits	20
main objective	20
polymorphonuclear leukocytes	20
stress response	20
may become	20
mean saps	20
drug interactions	20
mean icp	20
results will	20
different cell	20
syndrome date	20
low doses	20
cell population	20
boston cohort	20
inflammatory properties	20
different stages	20
ill icu	20
survival time	20
cerebral ischemia	20
relatively high	20
plasma lactate	20
kg iv	20
healthy lungs	20
emergency care	20
liver injury	20
markedly increased	20
important cause	20
cfu ml	20
fluid infusion	20
nasogastric tube	20
laboratory tests	20
tracheal pressure	20
angiotensin i	20
general anaesthesia	20
lung wet	20
inflection point	20
isolated bacteria	20
significant risk	20
ann intensive	20
highly significant	20
secondary outcome	20
two types	20
massive pulmonary	20
lactic acid	20
performed according	20
last decade	20
multicenter prospective	20
chronic diseases	20
high volume	20
surfactant phospholipids	20
mass spectrometry	20
cd expression	20
useful tool	20
factor associated	20
total lung	20
epithelial lining	20
weight loss	20
randomly allocated	20
among others	20
hiv infection	20
acute illness	20
large amounts	20
mean pao	20
potential risk	20
ali susceptibility	20
ventilator induced	20
peak pressure	20
mouse lungs	19
prolonged weaning	19
ards associated	19
fisher exact	19
complications associated	19
lung units	19
fresh frozen	19
favorable outcome	19
results obtained	19
improve clinical	19
national institute	19
tissue disease	19
positive effects	19
better survival	19
cell extracellular	19
related infections	19
plasma endotoxin	19
arterial thrombosis	19
forced expiratory	19
gel electrophoresis	19
antibiotic use	19
ultraprotective ventilation	19
infected cells	19
volume curve	19
activator receptor	19
upar system	19
male wistar	19
recent advances	19
surgical trauma	19
bl mice	19
dna damage	19
eosinophilic pneumonia	19
muscle strength	19
continuous intravenous	19
clinical variables	19
limited number	19
cell responses	19
positive cells	19
lower levels	19
icu setting	19
first postoperative	19
oxygen transport	19
rat lungs	19
care services	19
kidney function	19
bleeding complications	19
wide variety	19
six months	19
multiple logistic	19
resp score	19
ventilation settings	19