trigram

This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

trigram	frequency
respiratory distress syndrome	2327
acute respiratory distress	2120
in patients with	1983
intensive care unit	1045
critically ill patients	1015
acute lung injury	920
as well as	833
the use of	827
of patients with	808
in critically ill	662
study was to	643
of this study	620
the aim of	615
is associated with	554
patients with severe	554
in the icu	533
of the patients	517
patients with acute	504
patients and methods	494
this study was	493
patients with ards	480
the presence of	479
length of stay	477
severe acute respiratory	475
according to the	454
was associated with	442
to evaluate the	430
in order to	416
aim of this	412
there was no	406
a total of	404
the incidence of	404
in intensive care	403
the development of	392
of mechanical ventilation	381
associated with a	376
the treatment of	375
the number of	374
the intensive care	370
extracorporeal membrane oxygenation	365
patients with covid	362
admitted to the	361
with acute respiratory	351
one of the	351
the effect of	343
of the study	339
the role of	329
in this study	328
patients admitted to	328
acute respiratory failure	322
to assess the	318
based on the	302
the effects of	299
the risk of	297
the control group	296
due to the	290
the acute respiratory	289
the severity of	288
to determine the	286
to the icu	280
acute respiratory syndrome	279
intensive care units	277
in the study	274
the most common	273
an increase in	267
in acute respiratory	267
been shown to	264
induced lung injury	263
ill patients with	262
the end of	255
of critically ill	254
morbidity and mortality	250
included in the	250
there was a	245
the management of	241
lung injury and	240
compliance with ethics	238
with ethics regulations	238
in ards patients	237
was used to	235
the time of	235
of acute respiratory	234
for patients with	233
associated with the	233
there were no	233
patients in the	231
the impact of	231
patients with a	231
the study was	231
during the first	229
the present study	228
before and after	224
mechanically ventilated patients	221
patients were included	221
were included in	219
the pathogenesis of	219
has been shown	219
in the first	213
it has been	209
was defined as	209
of intensive care	208
the need for	207
between the two	206
the two groups	206
the duration of	206
of these patients	205
in the treatment	205
in addition to	202
risk factors for	202
conflict of interest	200
a systematic review	199
of acute lung	199
and in the	197
in the intensive	196
adult respiratory distress	195
in the control	194
there is a	194
patients with sepsis	193
with septic shock	192
compared to the	191
at the time	191
in the lung	191
the study period	190
study is to	190
the results of	190
in both groups	189
lung injury in	186
factors associated with	186
related to the	185
role in the	183
to investigate the	183
of the disease	183
in our study	182
no conflict of	181
at the end	181
apache ii score	181
the diagnosis of	179
this study is	177
mesenchymal stem cells	177
associated with increased	175
the level of	175
in the lungs	173
there is no	173
for the treatment	172
the occurrence of	172
the absence of	172
acute kidney injury	171
analysis of the	169
renal replacement therapy	168
in terms of	168
in septic shock	166
was to evaluate	165
the purpose of	164
in these patients	164
as compared to	164
in of cases	164
of the lung	164
in acute lung	163
the berlin definition	163
the patients were	162
tumor necrosis factor	162
pao fio ratio	162
and septic shock	161
the rate of	160
the expression of	159
involved in the	158
invasive mechanical ventilation	158
during the study	158
cm h o	157
systematic review and	157
of our study	157
the patients with	156
the course of	156
mechanical ventilation and	155
duration of mechanical	155
are associated with	154
were associated with	154
patients with septic	154
to be a	153
total of patients	153
was observed in	152
patients who were	151
and acute respiratory	151
a number of	151
the majority of	151
in response to	149
significantly higher in	149
in the pathogenesis	149
we conducted a	148
of patients were	147
were admitted to	146
aim of the	146
traumatic brain injury	146
in icu patients	146
of lung injury	145
in all patients	144
review and meta	143
be associated with	142
the onset of	142
has not been	140
patients treated with	139
mortality in patients	139
in patients who	139
well as the	138
in the group	137
seems to be	135
we aimed to	135
multiple organ failure	134
mean arterial pressure	134
in the present	134
no significant difference	133
in mechanically ventilated	133
was performed in	133
mechanical ventilation in	133
a variety of	133
higher in the	132
the relationship between	132
of septic shock	131
end of the	131
group of patients	131
the efficacy of	131
for acute respiratory	131
respiratory syndrome coronavirus	131
severity of illness	129
in septic patients	129
on the other	128
in case of	127
were treated with	127
and mortality in	126
all patients were	126
quality of life	126
was significantly higher	126
of stay in	124
found to be	124
in the presence	124
we performed a	124
the first days	124
shown to be	122
compared with the	122
as compared with	122
can be used	122
distress syndrome in	122
associated with an	121
the emergency department	120
with severe ards	119
of ards patients	119
increased risk of	119
the first hours	119
of patients who	119
than in the	119
a period of	119
mortality rate was	119
purpose of this	119
the administration of	118
part of the	118
a decrease in	118
of icu stay	118
independently associated with	118
of severe acute	118
associated with mortality	118
the quality of	118
cause of death	117
because of the	117
not associated with	116
and outcomes of	116
patients had a	115
sepsis and septic	115
at least one	115
the other hand	115
is one of	115
diffuse alveolar damage	114
from january to	114
in the early	114
the production of	114
did not differ	114
as a result	113
more likely to	112
analysis was performed	112
mean age was	112
is characterized by	112
in of the	112
at icu admission	112
risk factor for	111
patients were admitted	111
number of patients	111
who did not	110
of the most	110
between the groups	110
icu and hospital	110
the outcome of	110
to compare the	109
our study was	109
respiratory syncytial virus	109
be used to	109
the objective of	108
we found that	108
in our icu	108
prospective observational study	108
the critically ill	108
an important role	107
are needed to	107
within the first	107
no difference in	107
a retrospective study	107
randomized controlled trial	106
may be a	106
a reduction in	106
this is a	106
has been reported	106
with a high	106
lower respiratory tract	106
was carried out	105
are shown in	105
is a common	105
have shown that	104
in the acute	104
with acute lung	104
approved by the	104
the degree of	104
was no difference	104
no significant differences	103
patients who had	103
the levels of	103
in the management	103
the influence of	103
intensive care medicine	103
for more than	102
the prevalence of	102
the release of	102
the importance of	102
admission to the	102
with severe sepsis	101
we did not	101
to study the	101
acute renal failure	101
significantly associated with	101
admitted to our	100
with regard to	100
at the same	100
was to assess	100
the patients who	100
of patients admitted	100
with or without	100
in contrast to	100
is the most	100
increase in the	99
septic shock patients	99
to describe the	99
was to determine	98
systemic inflammatory response	98
with and without	98
most of the	98
of the patient	98
the inflammatory response	98
the proportion of	98
hypoxemic respiratory failure	98
the application of	98
for at least	98
icu length of	98
important role in	97
difference between the	97
low tidal volume	97
severe sepsis and	97
used in the	96
the mortality rate	96
patients who died	96
x a x	96
patients who received	96
of the cases	96
the most frequent	96
adult patients with	95
activation of the	95
aim of our	95
appears to be	95
moderate to severe	94
were divided into	94
data suggest that	94
was the most	94
the activation of	93
was performed using	93
in of patients	93
when compared to	93
the lack of	93
severity of the	93
a prospective study	93
the primary outcome	92
of ards in	92
the percentage of	92
significant difference in	91
patients admitted in	91
objective of this	91
was no significant	91
were used to	91
the patient was	91
pediatric intensive care	91
mortality in the	91
with severe acute	91
to reduce the	90
area under the	90
the fi rst	90
defined as a	90
significant increase in	90
was found in	90
blood samples were	90
a result of	90
membrane oxygenation for	90
the ability of	90
clinical characteristics of	89
understanding of the	89
the fact that	89
the icu and	89
the first h	88
of critical care	88
the same time	88
risk of death	88
a x a	88
was higher in	88
the association between	88
a significant increase	88
the mean age	88
study was conducted	88
contribute to the	88
in the absence	87
h n influenza	87
organ failure assessment	87
between january and	87
been associated with	87
due to a	87
hospital cardiac arrest	87
we hypothesized that	87
levels of il	86
was used for	86
admitted to icu	86
the day of	85
high levels of	85
the amount of	85
and safety of	85
of all patients	85
be used as	85
to be the	85
high risk of	85
into two groups	85
and mechanical ventilation	85
was approved by	84
were no significant	84
was to investigate	84
used as a	84
the cause of	84
significant differences in	83
in children with	83
mechanical ventilation was	83
patients with obesity	83
to have a	83
to identify the	83
all patients with	83
in adult patients	83
all patients admitted	83
in critical care	83
of the respiratory	82
to the intensive	82
patients with the	82
of icu admission	82
were significantly higher	82
the frequency of	82
and hospital mortality	82
respiratory failure in	81
changes in the	81
among patients with	81
be due to	81
data were collected	81
neutrophil extracellular traps	81
with respect to	81
in severe ards	81
a role in	81
associated with higher	80
pulmonary vascular resistance	80
icu patients with	80
retrospective cohort study	80
of death in	80
inhaled nitric oxide	80
a group of	80
with a median	80
during mechanical ventilation	80
should be considered	79
is a major	79
were found in	79
the hypothesis that	79
the pathophysiology of	79
length of icu	79
was assessed by	79
of ards and	79
significant difference between	79
the increase in	79
was found to	79
found in the	78
with a mean	78
is an important	78
the basis of	78
the prognosis of	78
were observed in	78
the length of	78
objective was to	78
the respiratory system	77
were randomized to	77
study of patients	77
the acute phase	77
a prospective observational	77
injury and the	77
to our icu	77
results suggest that	77
observed in the	76
to improve the	76
distress syndrome and	76
may lead to	76
we investigated the	76
and duration of	76
of the present	76
statistical analysis was	76
studies have shown	76
in the emergency	75
considered to be	75
have been shown	75
we conclude that	75
in the united	75
positive airway pressure	75
all the patients	75
after cardiac surgery	75
in this group	75
such as the	75
ventilated patients with	75
the immune system	75
based on a	75
requiring mechanical ventilation	75
and intensive care	74
and treatment of	74
a randomized controlled	74
stay in the	74
at risk of	74
correlation between the	74
shown in table	74
the united states	74
and length of	74
showed that the	73
and the acute	73
was measured by	73
may contribute to	73
results of the	73
sequential organ failure	73
prone positioning in	73
in severe acute	73
admitted to a	73
induced acute lung	73
defined as the	73
from mechanical ventilation	73
pneumonia in wuhan	73
critical care medicine	73
in accordance with	73
and outcome of	72
resulted in a	72
of critical illness	72
in combination with	72
randomized clinical trial	72
were found to	72
for the first	72
with novel coronavirus	72
for acute lung	72
of ali ards	72
prospective cohort study	71
for treatment of	71
was present in	71
chronic obstructive pulmonary	71
compared to those	71
partial pressure of	71
for each patient	71
in the patients	71
was significantly lower	71
of stay was	71
patients were divided	71
obstructive pulmonary disease	70
and after the	70
in the alveolar	70
treatment of severe	70
by means of	70
the implementation of	70
to determine whether	70
ards patients with	70
the type of	70
did not change	70
of severe sepsis	70
it is not	70
depending on the	70
years of age	70
a diagnosis of	69
to be associated	69
hospitalized patients with	69
has also been	69
role of the	69
the current study	69
have been reported	69
patients with sars	69
is based on	68
evaluation of the	68
the correlation between	68
an increase of	68
patients infected with	68
patients at risk	68
in the literature	68
none of the	68
treatment of ards	68
was obtained from	68
in animal models	68
was not associated	68
patients suffering from	68
the evolution of	68
the most important	68
differences in the	68
to the development	68
of respiratory failure	68
multiple organ dysfunction	68
differences between the	68
among the patients	68
likely to be	67
there are no	67
in all cases	67
retrospective analysis of	67
extracorporeal life support	67
after cardiac arrest	67
associated with high	67
studies are needed	67
use of the	67
aim was to	67
further studies are	67
randomized controlled trials	67
use of corticosteroids	67
was used in	67
plasma levels of	67
the lungs of	67
on the basis	67
in the critically	66
could not be	66
may not be	66
inflammatory response syndrome	66
for critically ill	66
are presented as	66
to intensive care	66
of mortality in	66
it is a	66
disseminated intravascular coagulation	66
followed by a	66
the start of	66
arterial blood gas	66
course of the	66
with coronavirus disease	66
responsible for the	66
respiratory failure and	66
use of a	66
in ali ards	66
did not show	65
of prone positioning	65
v d v	65
was to compare	65
clinical features of	65
significant differences between	65
d v t	65
the adult respiratory	65
and h after	65
an increased risk	65
in the same	65
diagnosis of ards	65
lead to a	65
with ards and	65
in relation to	65
in the case	64
in clinical practice	64
primary outcome was	64
an intensive care	64
over a period	64
of our patients	64
the value of	64
from patients with	64
was conducted in	64
alveolar epithelial cells	64
can lead to	64
acute hypoxemic respiratory	64
hospital length of	63
difference in the	63
the effectiveness of	63
mortality rate of	63
in patients undergoing	63
with increased mortality	63
the case of	63
the extent of	63
on the day	63
icu stay and	63
associated with poor	63
in the development	63
alveolar type ii	63
be related to	63
in this setting	63
type ii cells	63
development of ards	63
and can be	63
mesenchymal stem cell	63
a recent study	63
be involved in	63
a retrospective cohort	63
of icu patients	62
hospital mortality was	62
were able to	62
was found between	62
defined by the	62
the context of	62
were higher in	62
divided into two	62
a risk factor	62
as part of	62
standard of care	62
arterial blood gases	62
randomised controlled trial	62
the addition of	62
patients who underwent	62
of patients had	62
with a higher	61
of patients in	61
animal models of	61
in the two	61
in cases of	61
mean age of	61
study was performed	61
the primary endpoint	61
of hospital stay	61
for the diagnosis	61
bronchoalveolar lavage fluid	61
on mechanical ventilation	61
to test the	61
samples were collected	61
the formation of	61
half of the	61
higher in patients	61
but not in	61
was performed to	61
in group a	61
the prone position	61
the regulation of	61
the group of	61
need to be	60
from the icu	60
of the following	60
logistic regression analysis	60
was a significant	60
of them were	60
was determined by	60
were subjected to	60
are expressed as	60
compared to patients	60
of the icu	60
suggest that the	60
work of breathing	60
obtained from the	60
correlated with the	60
prior to the	60
at the bedside	60
p f ratio	60
the association of	60
present study was	60
for severe acute	60
treatment of acute	60
medical intensive care	60
clinical course and	60
in vitro and	60
patients with moderate	60
pressure release ventilation	59
the possibility of	59
for all patients	59
we evaluated the	59
majority of patients	59
in the context	59
were enrolled in	59
stay in icu	59
have been described	59
effect on the	59
in a prospective	59
patients with and	59
cells in the	59
in group b	59
for the management	59
these patients were	59
patients were enrolled	59
the changes in	59
that can be	59
severe ards patients	59
of the two	59
at risk for	58
should not be	58
display the preprint	58
characteristics of the	58
x x x	58
leading cause of	58
granted medrxiv a	58
the most severe	58
license to display	58
play an important	58
a license to	58
to display the	58
in comparison to	58
were obtained from	58
medrxiv a license	58
the preprint in	58
the accuracy of	58
the setting of	58
were compared with	58
in which the	58
the analysis of	58
has granted medrxiv	58
a significant decrease	58
which was not	58
predicted body weight	58
who has granted	58
during icu stay	57
and patients with	57
with sepsis and	57
mechanical ventilation for	57
a series of	57
in multivariate analysis	57
who were admitted	57
were performed in	57
been reported to	57
that patients with	57
arterial blood pressure	57
the pao fio	57
in this context	57
of inspired oxygen	57
materials and methods	57
the induction of	57
of at least	57
airway pressure release	57
or septic shock	57
of the immune	57
the beginning of	57
was performed by	57
is the first	57
patients with influenza	57
all of the	57
included in this	57
is necessary to	56
been described in	56
of the first	56
the characteristics of	56
to analyze the	56
east respiratory syndrome	56
as soon as	56
admitted in icu	56
with an increased	56
risk factors associated	56
of patients infected	56
injury and acute	56
was based on	56
the copyright holder	56
has been associated	56
have not been	56
of corticosteroids in	56
a model of	56
higher risk of	56
middle east respiratory	56
serum levels of	56
in this population	56
led to a	56
increased in the	56
the introduction of	56
during the period	56
reduction in the	56
some of the	56
national or international	55
efficacy and safety	55
in the hospital	55
used for the	55
it is possible	55
test was used	55
copyright holder for	55
open lung biopsy	55
of the manuscript	55
needs to be	55
holder for this	55
it is important	55
body mass index	55
significant decrease in	55
to the study	55
respiratory system compliance	55
not significantly different	55
study was approved	55
in the ed	55
all patients had	55
in the setting	55
in survivors of	55
as shown in	55
died in the	55
patients who are	55
was performed with	55
and mechanically ventilated	55
in the blood	55
management of patients	54
a university hospital	54
review of the	54
observed in patients	54
is the author	54
to severe ards	54
mortality rate in	54
mean duration of	54
and is associated	54
the result of	54
or international congresses	54
polymerase chain reaction	54
invitation to national	54
reactive oxygen species	54
to be an	54
the combination of	54
the risk factors	54
to patients with	54
world health organization	54
the author funder	54
it should be	54
are presented in	54
to national or	54
seem to be	54
in a large	54
play a role	54
we studied the	54
the authors declare	54
in the course	53
significantly lower in	53
of the lungs	53
is known to	53
cohort of patients	53
is important to	53
the alveolar space	53
in patients admitted	53
was used as	53
risk of mortality	53
not differ between	53
within h of	53
has been proposed	53
was to describe	53
of stem cells	53
safety and efficacy	53
central venous pressure	53
tfr treg cells	53
has been demonstrated	53
risk of developing	53
of sepsis and	53
with respiratory failure	53
care units in	53
of the total	53
in severe covid	53
the identification of	52
central venous catheter	52
is known about	52
prolonged mechanical ventilation	52
septic shock and	52
and severity of	52
in critical illness	52
median age of	52
this was a	52
this version posted	52
a prospective cohort	52
care unit of	52
a significant reduction	52
known to be	52
in the following	52
survivors and non	52
with severe covid	52
oxygenation for severe	52
fraction of inspired	52
lower in the	52
pathogenesis of ards	52
of coronavirus disease	52
the area under	52
little is known	52
in the non	52
in comparison with	51
and at the	51
herpes simplex virus	51
has been used	51
the mechanism of	51
we compared the	51
patients were excluded	51
patients who developed	51
appear to be	51
the evaluation of	51
lung protective ventilation	51
with the use	51
and may be	51
definition of ards	51
after icu discharge	51
shown in fig	51
length of hospital	51
these data suggest	51
with an increase	51
a dose of	51
in the number	51
a combination of	51
more than of	51
the assessment of	51
group and in	51
risk factors of	51
january to december	51
critically ill adults	51
in icu and	51
for mechanical ventilation	51
of the alveolar	51
of the acute	51
assessment of the	51
levels in the	51
we used a	50
endothelial growth factor	50
h n virus	50
intensive care med	50
vascular endothelial growth	50
used to assess	50
a cohort of	50
first days of	50
is to evaluate	50
sepsis or septic	50
of the pulmonary	50
and of the	50
presence of a	50
in the last	50
after icu admission	50
patients were treated	50
the prevention of	50
randomized to receive	50
be explained by	50
has been described	50
no statistically significant	50
more than days	50
proportion of patients	50
associated with acute	50
did not have	49
acute myocardial infarction	49
patients who did	49
is common in	49
did not receive	49
patients were studied	49
the process of	49
to examine the	49
glasgow coma scale	49
according to a	49
the lung and	49
receiver operating characteristic	49
mortality in ards	49
median duration of	49
well as in	49
were measured in	49
patients in whom	49
groups of patients	49
discharge from the	49
lpv cds tool	49
required mechanical ventilation	49
be used for	49
the th day	49
addition to the	49
between patients with	49
out of the	49
causes of death	49
duration of mv	49
were measured by	49
was induced by	49
admitted in the	49
the activity of	49
increased levels of	49
and use of	49
informed consent was	49
a retrospective analysis	49
severe respiratory failure	49
major cause of	49
lower tidal volumes	49
age was years	49
at high risk	49
tidal volume ventilation	48
and risk factors	48
the concentration of	48
in bronchoalveolar lavage	48
were similar in	48
vitro and in	48
sensitivity and specificity	48
shown in figure	48
pressure support ventilation	48
to estimate the	48
surviving sepsis campaign	48
patients with ali	48
were collected from	48
of the data	48
we observed a	48
expression of the	48
were performed using	48
within hours of	48
enrolled in the	48
as a potential	48
reported to be	48
to predict the	48
and management of	48
inclusion criteria were	48
distress syndrome the	48
found that the	48
cd t cells	48
risk factors and	48
had a higher	48
caused by the	48
were used for	48
a history of	48
patients hospitalized in	48
systematic review of	48
and on the	47
elevated levels of	47
in univariate analysis	47
independent risk factors	47
effects of the	47
european society of	47
mortality and morbidity	47
more than one	47
we sought to	47
gas exchange and	47
retrospective observational study	47
and did not	47
the contribution of	47
of ml kg	47
no difference between	47
but did not	47
not different between	47
of more than	47
and has been	47
of ards is	47
of patients and	47
a lack of	47
moderate and severe	47
from the hospital	47
flow nasal cannula	47
has to be	47
of cmh o	47
in those with	47
the probability of	47
ventilation in the	47
retrospective study of	47
inflammatory response in	47
study showed that	46
in the analysis	46
european consensus conference	46
it can be	46
high incidence of	46
the icu stay	46
significant reduction in	46
likely to have	46
are involved in	46
of the clinical	46
pulmonary artery catheter	46
a consequence of	46
conducted a retrospective	46
the performance of	46
may also be	46
and hours after	46
when compared with	46
common cause of	46
any of the	46
of stay and	46
in the second	46
no differences in	46
were more likely	46
our understanding of	46
improvement in oxygenation	46
may be an	46
had to be	46
a marker of	46
all patients received	46
performed in patients	46
out of patients	46
we found a	46
the placebo group	46
patients admitted for	46
be able to	46
outcome of patients	46
carried out in	46
a high mortality	46
those who did	46
data are presented	46
in a patient	46
be considered as	46
the patient is	46
median age was	46
the lower respiratory	46
that there is	46
contributed to the	46
may be due	46
nitric oxide synthase	46
is a retrospective	46
not statistically significant	45
diagnosis and treatment	45
were the most	45
and in vivo	45
the leading cause	45
of novel coronavirus	45
of severe covid	45
data from the	45
neutral with regard	45
the ratio of	45
the difference between	45
published maps and	45
significantly different between	45
have been identified	45
and in patients	45
the decision to	45
the inclusion criteria	45
the mortality of	45
in published maps	45
levels were measured	45
and institutional affiliations	45
ml kg of	45
springer nature remains	45
remains neutral with	45
effect of the	45
was not significantly	45
regard to jurisdictional	45
jurisdictional claims in	45
not yet been	45
to the lung	45
considered as a	45
nature remains neutral	45
the period of	45
to investigate whether	45
icu mortality was	45
were excluded from	45
study of the	45
after the first	45
h and h	45
with high mortality	45
thought to be	45
with mortality in	45
in the clinical	45
maps and institutional	45
claims in published	45
and gas exchange	45
and chronic health	45
on the contrary	45
to jurisdictional claims	45
the average age	45
hospital mortality in	45
performed in the	45
this is the	45
of severe ards	45
blood gas analysis	45
which may be	44
a l p	44
dose of mg	44
in recent years	44
that the use	44
with lower tidal	44
ventilation with lower	44
can also be	44
red blood cells	44
independent predictor of	44
day mortality was	44
the endotracheal tube	44
under mechanical ventilation	44
systolic blood pressure	44
and the presence	44
with higher mortality	44
of h n	44
of ards was	44
society of intensive	44
expressed as mean	44
in the medical	44
was defined by	44
that of the	44
is shown in	44
consent was obtained	44
and multiple organ	44
in patients treated	44
a decrease of	44
the change in	44
of cases of	44
to the severity	44
decrease in the	44
no effect on	44
to the emergency	44
analyses were performed	44
on the use	44
frequency oscillatory ventilation	44
acute physiology score	44
chronic health evaluation	44
is related to	44
the ability to	44
more than h	44
hours after the	44
as a consequence	44
organ failure and	44
extravascular lung water	44
protective effect of	43
the median age	43
of mechanically ventilated	43
the site of	43
in each group	43
remains to be	43
clinical outcomes in	43
in patients receiving	43
conducted a prospective	43
may result in	43
could be used	43
and prognosis of	43
these results suggest	43
cytokine release syndrome	43
similar to those	43
the criteria for	43
the sofa score	43
ards due to	43
impact on the	43
o u r	43
increased mortality in	43
written informed consent	43
patients did not	43
to understand the	43
mortality for patients	43
in the past	43
with a significant	43
it is also	43
to determine if	43
the study and	43
a patient with	43
the last years	43
patients with coronavirus	43
intensive care patients	43
of inflammatory cytokines	43
been reported in	43
and sofa score	43
preprint in perpetuity	43
which can be	43
the nature of	43
of multiple organ	43
management of severe	43
and should be	43
in line with	43
are the most	43
for the development	42
associated with improved	42
our intensive care	42
r n a	42
was detected in	42
duration of the	42
o o f	42
j o u	42
activity of the	42
with a lower	42
in association with	42
two groups of	42
analysis of a	42
did not find	42
was performed on	42
due to their	42
on the first	42
high mortality rate	42
a review of	42
multivariate logistic regression	42
the median time	42
and prone positioning	42
the reduction of	42
to the patient	42
was calculated as	42
determined by the	42
a significant correlation	42
a mouse model	42
electrical impedance tomography	42
u r n	42
patients included in	42
and apache ii	42
the patients had	42
r o o	42
study aimed to	42
ards patients and	42
l p r	42
we included patients	42
the detection of	42
results of a	42
central nervous system	42
in the pulmonary	42
gas exchange in	42
an observational study	42
a median of	42
associated with hospital	42
n a l	42
mean airway pressure	42
p r e	42
could be a	42
an association between	42
correlation was found	42
there is an	42
first hours of	42
p r o	42
in this case	42
was designed to	42
in a recent	41
mortality in critically	41
was not statistically	41
is due to	41
ii score was	41
and efficacy of	41
of less than	41
an independent predictor	41
was shown to	41
the animals were	41
the first week	41
plasminogen activator inhibitor	41
mouse model of	41
tidal volumes for	41
to define the	41
this group of	41
impact of the	41
icu admission was	41
with h n	41
in trauma patients	41
january and december	41
be used in	41
been used in	41
performed using the	41
alveolar fluid clearance	41
have demonstrated that	41
with hospital mortality	41
the critical care	41
the safety and	41
ill patients in	41
acute physiology and	41
critically ill children	41
compared with traditional	41
age of the	41
novel coronavirus in	41
for septic shock	41
the early phase	41
volumes for acute	41
the immune response	41
depends on the	41
exclusion criteria were	41
in the current	41
a high risk	41
was able to	41
authors declare that	41
higher than in	41
the clinical course	41
and those with	41
cohort study of	41
patients will be	41
our study is	41
patients with suspected	41
physiology and chronic	41
days after the	40
to be more	40
our aim was	40
this retrospective study	40
leads to a	40
beneficial effects of	40
outcomes in patients	40
should be used	40
patients with pneumonia	40
in some patients	40
the icu of	40
be useful in	40
to that of	40
the care of	40
to measure the	40
in a group	40
used to identify	40
consistent with the	40
results indicate that	40
volumes as compared	40
and the use	40
positive pressure ventilation	40
up to days	40
is a key	40
the potential for	40
in ards and	40
simplified acute physiology	40
than that of	40
icu admission and	40
critically ill covid	40
are able to	40
data on the	40
with traditional tidal	40
a pilot study	40
tidal volumes as	40
it may be	40
of proinflammatory cytokines	40
prognostic value of	40
were analyzed using	40
were defined as	40
and those who	40
of nitric oxide	40
compared with those	40
characteristics and outcomes	40
approved the final	40
signifi cant diff	40
outcomes of critically	40
characterized by a	40
and approved the	40
and mortality for	40
traditional tidal volumes	40
days in the	40
were compared to	40
acute phase of	40
groups according to	40
pandemic influenza a	39
the usefulness of	39
assessed by the	39
driving pressure and	39
this article is	39
components of the	39
strongly associated with	39
and clinical data	39
respiratory mechanics and	39
the need of	39
were determined by	39
is not a	39
and the other	39
median length of	39
sofa score at	39
guidelines for the	39
cells of the	39
at room temperature	39
to play a	39
was not certified	39
significant correlation between	39
in the table	39
in the initial	39
in the right	39
syndrome in intensive	39
the icu for	39
between survivors and	39
failure due to	39
neuromuscular blocking agents	39
in spite of	39
nature of the	39
considered statistically significant	39
a control group	39
we examined the	39
of mg kg	39
by peer review	39
an average of	39
sofa score was	39
the first time	39
mechanical ventilation is	39
with poor outcome	39
observational study of	39
the safety of	39
patients were classified	39
reported in the	39
were mechanically ventilated	39
not certified by	39
was similar in	39
measurements were performed	39
certified by peer	39
a reduction of	39
was significantly associated	38
was seen in	38
according to their	38
the decrease in	38
were not significantly	38
independent risk factor	38
in a rat	38
in sepsis and	38
and development of	38
patients who survived	38
to hospital discharge	38
statistically significant difference	38
which has been	38
of organ failure	38
surgical intensive care	38
higher incidence of	38
features of patients	38
the lpv cds	38
data were analyzed	38
continuous renal replacement	38
receiving mechanical ventilation	38
we used the	38
patients have been	38
positioning in severe	38
a mean age	38
units in countries	38
of spontaneous breathing	38
hospital mortality rate	38
of hospitalized patients	38
interstitial lung disease	38
that they have	38
in adults with	38
a and b	38
study was designed	38
pulmonary arterial pressure	38
severe traumatic brain	38
management of covid	38
that in the	38
the most frequently	38
patterns of care	38
predictor of mortality	38
included patients with	38
may have a	38
in the plasma	38
and it is	38
day and day	38
similar to the	38
the patients in	38
with the severity	38
was lower in	38
a randomized clinical	38
h after the	38
the first day	38
all of them	38
similar in both	38
of the right	38
this may be	38
are known to	38
in the future	38
chronic kidney disease	38
incidence of ards	38
in most cases	38
present in the	38
and an increase	38
supported by the	38
during the last	38
was higher than	38
in the postoperative	38
to the lungs	38
in the placebo	38
all patients who	38
ards is a	37
a higher mortality	37
derived mesenchymal stem	37
resulting in a	37
large number of	37
no signifi cant	37
read and approved	37
our objective was	37
quality of care	37
is caused by	37
an improvement in	37
the lungs and	37
in clinical trials	37
study in a	37
were not different	37
in severe sepsis	37
yet to be	37
is defined as	37
coronary artery bypass	37
the university hospital	37
may be useful	37
mg kg h	37
in a mouse	37
logistic regression model	37
development of a	37
a pao fio	37
on admission to	37
were classified as	37
early acute respiratory	37
in the lower	37
high doses of	37
influenza a virus	37
of the inflammatory	37
the most commonly	37
admission to icu	37
shown in the	37
the age of	37
in patients at	37
after onset of	37
to receive either	37
is involved in	37
were compared using	37
two groups were	37
they have no	37
early phase of	37
was the only	37
for these patients	37
and lung injury	37
in patients in	37
novel coronavirus pneumonia	37
leading to a	37
been shown that	37
after discharge from	37
associated with lower	37
has been suggested	37
group than in	37
patients with novel	37
mechanical ventilation with	37
in two groups	37
measured in the	37
a sensitivity of	37
continuous positive airway	37
of morbidity and	37
of disease severity	37
of cardiac arrest	37
more than hours	37
plasma concentrations of	37
we found no	37
death in patients	37
seen in the	37
clinical and laboratory	37
outcomes of patients	37
high morbidity and	37
treatment of covid	37
the loss of	37
subgroup of patients	36
idiopathic pulmonary fibrosis	36
organ dysfunction syndrome	36
demonstrated that the	36
in the prone	36
spontaneous breathing trial	36
the icu was	36
was noted in	36
as previously described	36
of this work	36
at least days	36
severity of disease	36
data will be	36
with the development	36
at the icu	36
number of days	36
ill patients and	36
of the control	36
mortality of patients	36
therapy in the	36
apache ii scores	36
was due to	36
effects on the	36
each of the	36
the increase of	36
clinical signs of	36
after days of	36
similar to that	36
and outcome in	36
is responsible for	36
shown that the	36
regulation of the	36
may be used	36
of a large	36
stem cells and	36
were randomly assigned	36
in our cohort	36
discharged from the	36
of cases and	36
all rights reserved	36
up to of	36
mesenchymal stromal cells	36
different between the	36
total number of	36
the need to	36
significantly higher than	36
is made available	36
in two patients	36
associated with covid	36
septic shock in	36
the potential to	36
whitney u test	36
in hospitalized patients	36
results of this	36
patients and the	36
with ali ards	36
treatment of patients	36
a key role	36
of prone position	36
to decrease the	36
period of months	36
was considered statistically	36
relationship between the	36
to increase the	36
in a cohort	36
the feasibility of	36
associated with ards	36
study conducted in	36
cause of ards	36
associated with severe	36
used as an	36
of the work	35
mg kg day	35
in lung injury	35
at admission and	35
we believe that	35
the novel coronavirus	35
septic patients with	35
statistically significant differences	35
international license it	35
we assessed the	35
and to evaluate	35
a major role	35
in a medical	35
this suggests that	35
the european society	35
license it is	35
compared to controls	35
made available under	35
accordance with the	35
to confirm the	35
have been used	35
the final manuscript	35
are required to	35
was evaluated by	35
peripheral blood mononuclear	35
patients presenting with	35
not related to	35
higher levels of	35
studies have demonstrated	35
in those who	35
the apache ii	35
aimed to assess	35
in a tertiary	35
may be associated	35
the magnitude of	35
mean apache ii	35
taken into account	35
of pulmonary edema	35
predictors of mortality	35
that has been	35
to the clinical	35
patients compared to	35
no evidence of	35
of inflammatory mediators	35
the response to	35
was measured in	35
within hours after	35
to an increase	35
for management of	35
note springer nature	35
it is made	35
ards in the	35
in an intensive	35
tidal volume and	35
explained by the	35
observational study was	35
body surface area	35
a major cause	35
function of the	35
available under a	35
a mortality rate	35
with moderate to	35
a higher risk	35
had no effect	35
in a dose	35
only in the	35
have to be	35
under the curve	35
levels were significantly	35
connected to a	35
the nlrp inflammasome	34
well as a	34
were collected at	34
be responsible for	34
to the hospital	34
berlin definition of	34
the measurement of	34
leading to the	34
a post hoc	34
by flow cytometry	34
may be the	34
patients with confirmed	34
outcome of the	34
implementation of a	34
the choice of	34
endothelial cells and	34
the distribution of	34
at any time	34
is thought to	34
in out of	34
of the main	34
of the covid	34
ligation and puncture	34
in the liver	34
led to the	34
a study of	34
characteristics of patients	34
and of patients	34
its impact on	34
society of critical	34
injury in mice	34
of septic patients	34
a predictor of	34
evaluate the effect	34
component of the	34
on the th	34
care med doi	34
in the most	34
the function of	34
peep cmh o	34
in those patients	34
icu of a	34
a median age	34
critically ill patient	34
ranging from to	34
ml kg h	34
as defined by	34
the first three	34
treated with ecmo	34
an indicator of	34
knowledge of the	34
improvement in the	34
outcome was the	34
individual patient data	34
ml cmh o	34
and driving pressure	34
in an experimental	34
were no differences	34
in the diagnosis	34
more frequent in	34
was measured using	34
and mortality of	34
major role in	34
a significant difference	34
were used in	34
ards caused by	34
day mortality in	33
a statistically significant	33
prone position in	33
and clinical characteristics	33
patients with pulmonary	33
a mean of	33
differences were found	33
age of years	33
there have been	33
within h after	33
ventilation in acute	33
production of il	33
or equal to	33
to prevent the	33
not able to	33
infected with sars	33
to explore the	33
a case of	33
time course of	33
glasgow coma score	33
the results were	33
in adult respiratory	33
critical care unit	33
of the human	33
red blood cell	33
is likely to	33
von willebrand factor	33
transforming growth factor	33
is a frequent	33
used to compare	33
is essential to	33
showed a significant	33
was applied to	33
critical illness and	33
for the use	33
after initiation of	33
a p value	33
males and females	33
the icu with	33
at hospital discharge	33
to the use	33
a rat model	33
the statistical analysis	33
patients with an	33
outcome in patients	33
as high as	33
is needed to	33
the cytokine storm	33
ali ards patients	33
the goal of	33
no correlation between	33
infected with novel	33
two or more	33
may play a	33
suggests that the	33
cecal ligation and	33
of acute kidney	33
clinical and biological	33
injury severity score	33
levels of tnf	33
in our patients	33
declare that they	33
of the adult	33
institutional review board	33
in all the	33
were carried out	33
we developed a	33
in the regulation	33
levels of the	33
of the university	33
of inflammation and	33
samples were taken	33
to our knowledge	33
one or more	33
of antibiotic therapy	33
in patients without	33
due to an	33
average age of	33
should probably be	33
conventional mechanical ventilation	33
with mechanical ventilation	33
which is a	33
during this period	33
medical and surgical	33
at baseline and	33
risk of bias	33
of a new	33
observational cohort study	33
the study is	32
intensive care and	32
stay was days	32
disease severity and	32
the patient and	32
is used to	32
hours of icu	32
decreased in the	32
to cmh o	32
in patients and	32
model of acute	32
distress syndrome acute	32
the postoperative period	32
was not different	32
clinical course of	32
there was an	32
patients of the	32
for disease control	32
to be effective	32
data was collected	32
the accumulation of	32
analysis of variance	32
were measured at	32
high level of	32
in the respiratory	32
the lung injury	32
associated with decreased	32
were detected in	32
at day and	32
the study of	32
conducted in the	32
and specificity of	32
that have been	32
appeared to be	32
the world health	32
for this preprint	32
and the mean	32
during the icu	32
not show any	32
innate immune response	32
and clinical studies	32
due to its	32
on day p	32
levels of peep	32
there are several	32
for up to	32
univariate and multivariate	32
of spontaneous circulation	32
icu admission were	32
primary endpoint was	32
defined by a	32
the tidal volume	32
was induced in	32
demographic and clinical	32
in the patient	32
with a low	32
membrane oxygenation in	32
pulmonary artery pressure	32
to the control	32
period of time	32
no competing interests	32
and critical care	32
comparison of the	32
a significantly higher	32
therapy in patients	32
suggested that the	32
were measured using	32
prognosis of patients	32
the diagnosis and	32
the initiation of	32
increase of the	32
apache ii and	32
over the last	32
cytokines such as	32
blood mononuclear cells	32
the systemic inflammatory	32
the ethics committee	32
performed in a	32
added to the	32
patients were randomized	32
ventilation in patients	32
and respiratory failure	32
measured by the	32
onset of ards	32
the time course	32
were collected and	32
randomly assigned to	32
reason for admission	32
during and after	32
in our unit	32
prospective study was	32
development of acute	32
lung epithelial cells	31
of mesenchymal stem	31
regardless of the	31
after adjustment for	31
in the adult	31
congestive heart failure	31
higher than the	31
necrosis factor alpha	31
mean length of	31
severe sepsis or	31
was to identify	31
the volume of	31
support scientific studies	31
severity of ards	31
detected in the	31
research support scientific	31
is supported by	31
at least in	31
patients with chronic	31
the group with	31
on admission and	31
to identify patients	31
prone positioning and	31
and death in	31
the mechanisms of	31
is difficult to	31
months after discharge	31
due to covid	31
early detection of	31
did not affect	31
type ii pneumocytes	31
be taken into	31
at least h	31
control and prevention	31
the following parameters	31
consensus conference on	31
purpose of the	31
and to identify	31
recent studies have	31
of positive end	31
lung injury by	31
by using the	31
in one patient	31
study aims to	31
of organ dysfunction	31
statistically signifi cant	31
the university of	31
acute exacerbation of	31
the clinical and	31
with a diagnosis	31
used to determine	31
that it is	31
findings suggest that	31
defined as an	31
in arterial blood	31
in pao fio	31
this prospective study	31
shown to reduce	31
whether or not	31
the coronavirus disease	31
in a variety	31
the patient with	31
distress syndrome with	31
were present in	31
and severe ards	31
it is necessary	31
an independent risk	31
inflammation in the	31
of the procedure	31
in early acute	31
pressure of oxygen	31
cardiogenic pulmonary edema	31
the rest of	31
and that the	31
the incidence and	31
the involvement of	31
post hoc analysis	31
this work was	31
hospitalized in the	31
children with severe	31
of the literature	31
excluded from the	31
of the host	31
be a useful	31
protective effects of	31
compared to non	31
used to evaluate	31
patients and their	31
in this retrospective	31
that there was	31
of corticosteroids for	31
of respiratory distress	31
the form of	30
we aim to	30
cardiac arrest and	30
to those of	30
to be determined	30
difference in mortality	30
is consistent with	30
in our hospital	30
the data were	30
be considered in	30
cd and cd	30
weaning from mechanical	30
occurred in patients	30
measured at the	30
is to assess	30
results show that	30
after the onset	30
in group i	30
patients in group	30
of the major	30
the icu in	30
and had a	30
of this disease	30
analysis showed that	30
it was not	30
and a higher	30
diagnosis of sepsis	30
to be involved	30
in an icu	30
for patients who	30
was to analyze	30
was independently associated	30
on the icu	30
it was found	30
to the berlin	30
stem cells in	30
will not be	30
known about the	30
functional residual capacity	30
the normal range	30
the roc curve	30
as measured by	30
implementation of the	30
in pediatric patients	30
pao fio mmhg	30
a change in	30
the department of	30
will be performed	30
and to determine	30
in the uk	30
were performed by	30
better understanding of	30
congenital heart disease	30
on the management	30
incidence of vap	30
in icu for	30
was measured at	30
was the main	30
results a total	30
in the post	30
of extracellular vesicles	30
the overall mortality	30
angiotensin converting enzyme	30
be an important	30
the improvement of	30
human mesenchymal stem	30
from the ventilator	30
a report of	30
treatment of the	30
of the european	30
phase of ards	30
patients with respiratory	30
for a period	30
in a study	30
the prognostic value	30
criteria for ards	30
with the control	30
failure in the	30
and respiratory rate	30
has led to	30
lung injury score	30
is required to	30
days after admission	30
the existence of	30
response to the	30
of a tertiary	30
injury induced by	30
was similar to	30
were analyzed by	30
a rate of	30
retrospective study was	30
intercellular adhesion molecule	30
may be related	30
the study population	30
a h n	30
study suggests that	30
in the majority	30
in one case	30
the emergence of	30
no change in	30
this study we	30
caused by a	29
analysis of data	29
and for the	29
to a significant	29
early in the	29
performed a retrospective	29
patients with low	29
with at least	29
patients with high	29
this preprint this	29
vivo lung perfusion	29
of nosocomial infections	29
result in a	29
number of ventilator	29
evolution of the	29
not differ significantly	29
presented in table	29
the timing of	29
of this article	29
was in the	29
and the risk	29
rat model of	29
of extracorporeal membrane	29
pediatric patients with	29
induced acute respiratory	29
in vitro studies	29
patients diagnosed with	29
the patients and	29
criteria for the	29
lung injury acute	29
patients in intensive	29
plays an important	29
in a significant	29
a maximum of	29
the inhibition of	29
of the current	29
referred to as	29
in the ards	29
samples were obtained	29
in icu was	29
have been proposed	29
all consecutive patients	29
were due to	29
are reported in	29
on mortality in	29
host response to	29
and clinical trial	29
application of the	29
and a significant	29
significant differences were	29
and to the	29
which is associated	29
first h of	29
in the late	29
was a prospective	29
cases of covid	29
cardiac surgery with	29
tended to be	29
high prevalence of	29
the median duration	29
in the other	29
at a dose	29
had significantly higher	29
results in a	29
are likely to	29
positive predictive value	29
clinical trial of	29
after hospital discharge	29
presented as mean	29
the range of	29
if there is	29
not lead to	29
who died in	29
the dose of	29
preprint this version	29
were considered as	29
course and outcomes	29
the emergency room	29
especially in the	29
a significant improvement	29
was assessed using	29
phase of the	29
were incubated with	29
in this prospective	29
for severe ards	29
if the patient	29
and the need	29
of the time	29
the total number	29
high rate of	29
as assessed by	29
defi ned as	29
a large number	29
ards patients were	29
in a model	29
the concept of	29
american thoracic society	29
in a murine	29
this study were	29
v a q	29
a case report	29
serve as a	29
coronavirus in wuhan	29
of neutrophils in	29
with the acute	29
a pivotal role	29
analysis was used	29
significantly increased in	29
at the beginning	29
the patients included	29
studies suggest that	29
in some cases	29
is a rare	29
most common cause	29
key role in	29
a novel coronavirus	29
the progression of	29
with an average	29
were similar to	29
extracorporeal co removal	29
mechanical ventilation were	29
acute circulatory failure	29
eff ect of	29
admitted to intensive	28
time of the	28
have also been	28
the moment of	28
information about the	28
cause of mortality	28
hoc analysis of	28
endothelial cell barrier	28
associated acute respiratory	28
would like to	28
with severe respiratory	28
but it is	28
internal jugular vein	28
as a possible	28
revision of the	28
influenced by the	28
and hospital length	28
and patients were	28
patients with mild	28
those who died	28
ethics committee of	28
due to acute	28
by the use	28
for ali ards	28
average age was	28
and activation of	28
of s p	28
inflammatory lung injury	28
contributes to the	28
with high morbidity	28
to identify factors	28
in obese patients	28
icu stay was	28
development of the	28
the primary objective	28
predictive value of	28
a difference in	28
in a university	28
to be used	28
during the course	28
previous studies have	28
return of spontaneous	28
data indicate that	28
was signifi cantly	28
of group a	28
for icu admission	28
were diagnosed with	28
performed by the	28
organ failure in	28
measurement of the	28
diff erence in	28
survival in the	28
had at least	28
low levels of	28
were assessed by	28
ards may be	28
were performed with	28
management of the	28
the surface of	28
the present case	28
found to have	28
under the roc	28
as in the	28
to one of	28
damage to the	28
increase the risk	28
is protected by	28
material and methods	28
the main cause	28
small number of	28
clinical trials of	28
reduce the risk	28
in both the	28
found between the	28
of the experiment	28
its role in	28
th and th	28
may help to	28
consecutive patients with	28
was related to	28
the work of	28
along with the	28
those with a	28
were admitted in	28
was considered as	28
should also be	28
l min m	28
in a retrospective	28
is able to	28
contrast to the	28
result of the	28
provided by the	28
and icu mortality	28
hypoxic respiratory failure	28
were related to	28
the patients was	28