trigram

This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

trigram	frequency
stem cell transplantation	1644
in patients with	1283
hematopoietic stem cell	953
as well as	846
the use of	683
cd t cells	629
the presence of	623
of patients with	551
of the patients	547
conflict of interest	522
disclosure of conflict	479
of conflict of	479
the incidence of	463
the development of	431
allogeneic stem cell	418
the treatment of	408
is associated with	398
allogeneic hematopoietic stem	396
with a median	389
the time of	380
the role of	372
the risk of	369
for patients with	360
a total of	359
the number of	359
the most common	356
in order to	354
at the time	347
stem cell transplant	321
a median of	318
in this study	317
nothing to declare	316
cd and cd	306
there was no	303
was associated with	299
associated with a	298
according to the	292
a median follow	288
the absence of	283
of this study	274
cumulative incidence of	272
study was to	267
one of the	263
risk factors for	263
due to the	263
the majority of	257
morbidity and mortality	257
the impact of	254
bone marrow transplantation	249
the aim of	245
was observed in	243
at a median	237
the diagnosis of	235
peripheral blood stem	229
this study was	224
patients who received	221
the effect of	220
lung transplant recipients	218
versus host disease	217
in the first	216
the outcome of	214
graft versus host	214
were treated with	213
in the absence	212
as compared to	211
in addition to	210
median age of	208
in terms of	208
median age was	203
the median age	202
in patients who	201
to evaluate the	201
for the treatment	200
by flow cytometry	199
in the presence	196
has not been	195
patients with a	193
median time to	192
hematopoietic cell transplantation	191
the expression of	189
years of age	188
based on the	188
found to be	185
in all patients	185
there were no	184
autologous stem cell	183
cd t cell	182
aim of this	182
been shown to	180
cells in the	178
acute myeloid leukemia	176
there was a	174
the median time	171
is the most	171
compared to the	169
in combination with	169
mg kg day	168
stem cell source	167
t cells and	166
in of patients	165
has been reported	165
organ transplant recipients	165
t cells in	164
all patients received	162
to determine the	161
in the treatment	161
of the disease	159
solid organ transplant	159
median follow up	158
in response to	156
median age at	156
patients who underwent	156
of these patients	154
we found that	153
the conditioning regimen	153
reduced intensity conditioning	152
was used to	150
and in the	150
with or without	150
associated with the	150
has been shown	149
after allogeneic hematopoietic	149
was found to	149
and chronic gvhd	148
should be considered	148
the setting of	147
acute and chronic	146
there is no	146
in the setting	146
increased risk of	145
the frequency of	145
and cd t	145
were associated with	144
been associated with	143
patients in the	143
to assess the	143
it has been	143
the united states	143
are associated with	142
age was years	142
all patients were	142
t cells were	141
there is a	141
human immunodeficiency virus	140
up of months	140
role in the	140
during the first	139
risk factor for	139
a number of	138
the present study	137
of patients who	137
of acute gvhd	136
after a median	136
median time of	136
in both groups	136
in children with	135
blood stem cells	135
quality of life	134
were included in	134
patients treated with	132
in solid organ	132
median number of	131
renal transplant recipients	131
herpes simplex virus	130
of cd cells	130
be associated with	129
the most frequent	129
have been reported	129
the cumulative incidence	128
patients with acute	128
respiratory syncytial virus	128
of cmv infection	127
the management of	127
the efficacy of	127
shown to be	126
a variety of	126
bone marrow transplant	126
the results of	125
total of patients	124
the first year	124
blood stem cell	124
in lung transplant	123
in these patients	123
after allogeneic stem	123
to be a	122
in the united	121
the patients with	120
of the immune	120
a patient with	120
haematopoietic stem cell	119
the immune system	119
no significant difference	119
polymerase chain reaction	118
cell transplant recipients	118
analysis of the	118
a history of	117
months of age	117
the rate of	117
for the first	116
as part of	116
data suggest that	115
intensive care unit	115
of t cells	115
acute lymphoblastic leukemia	115
within the first	114
included in the	114
before and after	114
is a rare	113
as a result	113
the patient was	113
specific t cells	112
at time of	112
in peripheral blood	112
well as the	112
median of days	111
the onset of	111
of the study	111
was defined as	111
of cd t	111
patients who had	110
none of the	110
associated with increased	110
follow up of	110
involved in the	110
to investigate the	109
and overall survival	109
the age of	108
the risk for	108
the course of	108
was performed in	108
cell transplantation in	107
the importance of	107
the occurrence of	107
cohort of patients	107
specific cd t	107
seems to be	107
in contrast to	106
the pathogenesis of	106
was detected in	105
allogeneic hematopoietic cell	105
significant difference in	104
in of the	104
for treatment of	104
in a patient	104
in the early	104
solid organ transplantation	104
total body irradiation	104
at least one	103
infection in the	103
of patients were	103
was significantly higher	102
year overall survival	102
the lack of	102
and treatment of	102
in renal transplant	102
the need for	101
number of patients	101
a median time	100
in the study	100
a median age	100
of t cell	100
was used in	100
can be used	100
with respect to	100
conditioning regimen was	99
is one of	99
majority of patients	99
umbilical cord blood	99
in multivariate analysis	99
an increase in	99
age of years	99
associated with an	98
patients with severe	98
the first months	98
the induction of	97
to reduce the	97
patients with high	97
may be a	97
in our center	97
in immunocompromised patients	96
the end of	96
a result of	96
incidence of relapse	96
cause of death	96
number of cd	95
because of the	94
the patients who	94
patients who were	94
was seen in	94
when compared to	94
out of patients	94
a combination of	94
is characterized by	94
the effects of	93
in case of	93
central nervous system	92
part of the	92
a cohort of	92
used in the	92
been reported in	92
between january and	92
patients received a	92
regulatory t cells	92
group of patients	92
an important role	92
the level of	92
results suggest that	91
been reported to	91
patients were treated	91
all patients had	91
significantly higher in	91
and bone marrow	91
matched unrelated donor	91
the addition of	90
were used to	90
gd t cells	90
the prevalence of	90
the context of	90
related to the	90
a role in	89
iv acute gvhd	89
the case of	89
appears to be	89
are needed to	89
lower respiratory tract	88
the activation of	88
in the present	88
were able to	88
the combination of	88
of chronic gvhd	88
of stem cells	88
the two groups	87
the first days	87
this is the	87
increase in the	87
we investigated the	87
patients had a	87
after hematopoietic stem	87
significantly associated with	87
the most important	87
in the context	86
safety and efficacy	86
in complete remission	86
no difference in	86
the production of	85
high levels of	85
in recipients of	85
on the other	85
were found to	85
has also been	85
is the first	85
depending on the	85
chronic gvhd was	85
hematopoietic stem cells	84
we show that	84
the severity of	84
in vitro and	84
we report the	84
incidence of acute	84
and management of	83
were observed in	83
the duration of	83
between the two	83
expression of the	82
t cell receptor	82
not associated with	82
with a high	82
the patients were	82
in association with	82
acute gvhd was	82
the median follow	82
resulted in a	82
for the development	82
the control group	81
patients with aml	81
used as a	81
hepatitis c virus	81
who did not	81
p disclosure of	80
t cells from	80
in all cases	79
the type of	79
an increased risk	79
was treated with	79
of the most	79
we performed a	79
study is to	78
neutrophil and platelet	78
and nk cells	78
found to have	78
at our institution	78
in transplant recipients	78
of cmv reactivation	78
most of the	77
a dose of	77
in comparison to	77
the other hand	77
we aimed to	77
and efficacy of	77
the prevention of	77
with and without	76
has been associated	76
t cell activation	76
important role in	76
need to be	76
is an important	76
allogeneic bone marrow	76
the proportion of	76
to analyze the	76
was no significant	75
full donor chimerism	75
of hematopoietic stem	75
can lead to	75
have shown that	75
the bone marrow	75
due to a	75
at our center	75
occurred in patients	75
the first time	75
in breast milk	75
and mortality in	75
higher in the	74
shown in table	74
and safety of	74
are shown in	74
compared to those	74
of the patient	74
of cd and	74
in patients undergoing	74
after lung transplantation	74
the t cell	73
died due to	73
in a single	73
in patients receiving	73
was used as	73
has been used	73
t cells with	73
of cd cd	72
was no difference	72
we retrospectively analyzed	72
in the literature	72
more likely to	72
west nile virus	72
median time from	72
t cell responses	72
analysis was performed	72
high risk of	72
have been described	72
we analyzed the	72
blood and marrow	72
dose of mg	72
have not been	72
from patients with	72
overall survival was	72
no significant differences	72
memory t cells	72
in pts with	71
patients are alive	71
the ability of	71
was diagnosed with	71
is important to	71
the identification of	71
observed in patients	71
cell transplantation for	71
t and b	71
patients were transplanted	71
in the group	71
median duration of	71
the percentage of	71
was used for	71
in the pathogenesis	70
this is a	70
at years was	70
was assessed by	70
was significantly lower	70
to identify the	70
play a role	70
transplant related mortality	70
a diagnosis of	70
was to evaluate	70
and mycophenolate mofetil	70
we conclude that	70
be considered in	70
be used to	69
for the diagnosis	69
a risk factor	69
of morbidity and	69
disclosure of interest	69
in pediatric patients	69
here we report	69
months after transplantation	69
in comparison with	69
there are no	69
for at least	69
risk of relapse	69
to have a	69
in bone marrow	68
the immune response	68
difference in the	68
it is not	68
to declare background	68
adult patients with	68
the fact that	68
heart transplant recipients	68
at the same	68
compared to patients	68
and platelet engraftment	67
we hypothesized that	67
the study was	67
minimal residual disease	67
of the virus	67
cd cd cd	67
was performed by	67
no evidence of	67
all patients with	67
causes of death	67
the detection of	67
severe acute respiratory	67
the overall survival	66
in our study	66
proportion of patients	66
myeloablative conditioning regimen	66
observed in the	66
acute gvhd grade	66
the general population	66
were diagnosed with	66
could not be	66
of allogeneic hematopoietic	66
patients with chronic	66
time to neutrophil	65
acute renal failure	65
from diagnosis to	65
after bone marrow	65
at a dose	65
donor and recipient	65
cmv infection in	65
patients were included	65
major cause of	65
patients with cmv	65
in cases of	65
a retrospective analysis	65
whole exome sequencing	65
in the case	65
at high risk	65
infections in the	65
to be the	65
the introduction of	65
was found in	65
the median number	65
of peripheral blood	64
t cell depletion	64
is a major	64
risk of developing	64
the outcomes of	64
suggest that the	64
contribute to the	64
outcome of patients	64
in patients and	64
in one patient	64
in children and	64
was diagnosed in	64
of nk cells	64
between the groups	64
higher incidence of	64
peripheral blood mononuclear	64
t cell proliferation	64
in the majority	64
kidney transplant recipients	64
and in vivo	64
in the last	63
bone marrow failure	63
may lead to	63
a single center	63
the basis of	63
compared with the	63
to study the	63
for the prevention	63
in der regel	63
found in the	63
prophylaxis consisted of	63
is the only	63
after the first	63
we observed a	63
present in the	63
blood mononuclear cells	63
a retrospective study	63
in our series	63
with an increased	62
it is important	62
of patients in	62
was performed using	62
was performed with	62
in the control	62
extensive chronic gvhd	62
at the end	62
incidence of cmv	62
to be associated	62
the purpose of	62
to compare the	62
this study we	62
the fi rst	61
patients who are	61
did not have	61
the same time	61
to the development	61
was higher in	61
as gvhd prophylaxis	61
all of them	61
in this setting	61
for all patients	61
this study is	61
patients with primary	61
retrospective analysis of	61
were detected in	61
have been shown	61
in this patient	61
the regulation of	60
of the first	60
the probability of	60
included in this	60
patients and methods	60
age at transplant	60
a and b	60
the administration of	60
associated with higher	60
up to of	60
factors associated with	60
of children with	60
was determined by	60
to patients with	60
the generation of	60
disease status at	60
higher risk of	60
marrow transplant recipients	60
expressed breast milk	60
of cmv disease	60
mutations in the	60
cord blood transplantation	60
and patients with	60
high rate of	59
cause of morbidity	59
in our cohort	59
were found in	59
hepatitis b virus	59
vitro and in	59
donor t cells	59
can also be	59
acute respiratory syndrome	59
b cells and	59
be considered as	59
severe combined immunodeficiency	59
with high risk	59
did not differ	59
are the most	59
and may be	59
has been described	59
the only curative	59
the ability to	58
infection of the	58
aim of the	58
liver transplant recipients	58
the degree of	58
this retrospective study	58
may contribute to	58
did not receive	58
on the basis	58
such as the	58
changes in the	58
of the liver	58
samples were collected	58
the possibility of	58
with multiple myeloma	58
be due to	58
transplant recipients with	58
were performed in	58
at risk of	58
a significant increase	58
was the most	58
with a history	58
is based on	58
the safety and	58
was achieved in	58
in the development	57
patients with hiv	57
were used as	57
the influence of	57
we did not	57
our data suggest	57
differences in the	57
of patients had	57
cd cell count	57
a review of	57
acute or chronic	57
was present in	57
resulting in a	57
studies are needed	57
of bone marrow	56
bone marrow and	56
a case of	56
the peripheral blood	56
with regard to	56
the quality of	56
at day and	56
expression of cd	56
we evaluated the	56
age of the	56
safe and effective	55
and t cell	55
results of a	55
not statistically significant	55
matched sibling donor	55
autologous hematopoietic stem	55
end of the	55
but not in	55
significantly lower in	55
to determine whether	55
to our knowledge	55
the objective of	55
mhc class i	55
increased risk for	55
activation of the	55
results of the	55
significant differences in	55
data indicate that	55
in the patients	55
patients were in	55
chronic granulomatous disease	54
data on the	54
reported to be	54
the cause of	54
invasive fungal infections	54
mg kg kg	54
and severity of	54
little is known	54
we observed that	54
source of stem	54
we conducted a	54
or chronic gvhd	54
review of the	54
matched related donor	54
is a common	54
more than of	54
the era of	54
viral infections in	54
median age years	54
common cause of	54
who received a	54
cell source was	54
after stem cell	54
at last follow	54
to declare p	53
in patients after	53
for prevention of	53
the stem cell	53
pneumocystis carinii pneumonia	53
after renal transplantation	53
showed that the	53
in a cohort	53
a prospective study	53
likely to be	53
at the age	53
among patients with	53
pediatric patients with	53
of acute and	53
we found a	53
acute graft versus	52
in the era	52
virus infection in	52
that can be	52
of the cases	52
some of the	52
respiratory tract infections	52
the association of	52
is caused by	52
we report a	52
show that the	52
fludarabine mg m	52
more than one	52
to that of	52
may also be	52
further studies are	52
cd cells were	52
haploidentical stem cell	52
efficacy and safety	52
the amount of	52
the day of	52
one patient with	52
were used in	52
of b cells	52
respiratory distress syndrome	52
t cells was	52
the analysis of	51
more common in	51
after allogeneic hsct	51
have been identified	51
high incidence of	51
in the patient	51
in hiv patients	51
patients with relapsed	51
with hiv infection	51
for patients who	51
and can be	51
option for patients	51
in recent years	51
the source of	51
be used as	51
any of the	51
was carried out	51
only one patient	51
with a higher	50
of patients and	50
matched unrelated donors	50
patients with aids	50
of our study	50
at months of	50
and b cells	50
of all patients	50
in hematopoietic stem	50
and stem cell	50
common variable immunodeficiency	50
were used for	50
the spectrum of	50
cd cells kg	50
was started on	50
to be effective	50
and marrow transplantation	50
of stem cell	50
and cd cells	50
in this group	50
were collected from	49
in a large	49
high risk patients	49
of the two	49
patients with hematological	49
the incidence and	49
objective of this	49
known to be	49
from the same	49
in this population	49
significant increase in	49
in out of	49
critically ill patients	49
in univariate analysis	49
in t cell	49
cell transplantation is	49
and one patient	49
progression free survival	49
of the cd	49
compared to healthy	49
up was months	49
prior to hsct	49
patients suffering from	49
the patient is	49
of infectious complications	49
each of the	49
t cells are	48
thought to be	48
the function of	48
play an important	48
one patient died	48
in which the	48
in the course	48
memory b cells	48
acute gvhd and	48
antigen presenting cells	48
studies have shown	48
is an effective	48
risk of infection	48
all the patients	48
we demonstrate that	48
was able to	48
on day and	48
a reduction in	48
clinical trial registry	48
and the median	48
cd cell dose	48
with acute leukemia	48
cytomegalovirus infection in	48
at years of	48
one or more	48
on day after	48
and outcome of	48
os and pfs	48
a significantly higher	48
members of the	48
was performed on	47
tumor necrosis factor	47
and peripheral blood	47
standard of care	47
gvhd prophylaxis was	47
time of transplant	47
depends on the	47
c bl mice	47
levels of il	47
in the blood	47
summarized in table	47
upper respiratory tract	47
be involved in	47
were transplanted in	47
at risk for	47
when compared with	47
has been demonstrated	47
patients have been	47
followed by a	47
patients with advanced	47
as compared with	47
a group of	47
has to be	47
have also been	47
the gastrointestinal tract	47
a decrease in	46
seen in the	46
a trend towards	46
in the immunocompromised	46
at transplant was	46
a period of	46
from peripheral blood	46
on days and	46
mg m day	46
in of cases	46
one patient had	46
gvhd prophylaxis consisted	46
we have previously	46
in the same	46
and the use	46
an unrelated donor	46
half of the	46
not significantly different	46
the patient with	46
status of the	46
patients with multiple	46
in adult patients	46
detected in the	46
is known about	46
t cells to	46
was confirmed by	46
are alive and	46
clinical and laboratory	46
follow up was	46
in those with	45
in more than	45
from an hla	45
after liver transplantation	45
and duration of	45
the primary endpoint	45
patients with agvhd	45
prior to the	45
year os was	45
neutrophil engraftment was	45
the first month	45
balb c mice	45
of the conditioning	45
bronchiolitis obliterans syndrome	45
t cell response	45
addition to the	45
in some cases	45
evaluation of the	45
from january to	45
fungal infections in	45
is known to	45
to improve the	45
transplantation in patients	45
have been associated	45
effect on the	45
infections in patients	45
with the same	45
months after hsct	45
flow cytometry and	45
of viral infections	45
in the diagnosis	45
the remaining patients	45
impact on the	45
reduction in the	45
are summarized in	45
been described in	45
allogeneic haematopoietic stem	44
were obtained from	44
understanding of the	44
highly active antiretroviral	44
in the general	44
are able to	44
therapy in patients	44
a significant reduction	44
most common cause	44
characteristics of the	44
patients who developed	44
we present a	44
immune repertoire classification	44
with hematological malignancies	44
diagnosis and management	44
a major cause	44
diagnosis and treatment	44
time from diagnosis	44
and did not	44
patients undergoing allogeneic	44
toxic shock syndrome	44
may not be	44
active antiretroviral therapy	44
used for the	44
of invasive fungal	44
high risk for	44
of infection in	44
in t cells	44
year cumulative incidence	44
had to be	44
role of the	44
from healthy donors	44
followed by autologous	44
is involved in	44
and has been	44
primary graft failure	43
needs to be	43
of the donor	43
with the use	43
days after transplantation	43
these results suggest	43
all of the	43
and should be	43
in the number	43
disease free survival	43
in the liver	43
for these patients	43
large number of	43
renal transplant patients	43
the median duration	43
unrelated cord blood	43
independently associated with	43
data show that	43
incidence of grade	43
guidelines for the	43
peripheral blood in	43
who underwent allogeneic	43
modern hopfield networks	43
of graft failure	43
from unrelated donors	43
with the development	43
for the management	43
the patients had	43
for children with	43
invasive fungal infection	43
we present the	43
were isolated from	43
of grade ii	43
a cause of	43
the most commonly	43
total number of	43
of mg kg	43
in allogeneic hematopoietic	43
were compared with	43
prior to transplant	43
and in patients	43
is thought to	43
stem cell mobilization	43
inflammatory bowel disease	43
in patients without	42
be able to	42
we were able	42
in the future	42
the dose of	42
vg vd t	42
chronic gvhd and	42
during the study	42
reduce the risk	42
in the two	42
acute respiratory distress	42
for gvhd prophylaxis	42
considered to be	42
and graft survival	42
in heart transplant	42
of them were	42
were analyzed by	42
and months after	42
or absence of	42
males and females	42
infection in a	42
and cord blood	42
the mechanism of	42
proved to be	42
in the transplant	42
were significantly higher	42
and outcomes of	42
and cd cd	42
found that the	42
of death were	42
of overall survival	42
we sought to	42
time of the	42
were no significant	42
the cd cd	42
was well tolerated	42
prior to transplantation	41
car t cells	41
well as in	41
engraftment was days	41
occurred in of	41
severe chronic gvhd	41
in hsct recipients	41
of our patients	41
for detection of	41
the current study	41
use of the	41
and the other	41
melphalan mg m	41
compared to controls	41
significant difference between	41
responsible for the	41
have been used	41
was performed to	41
bone marrow in	41
two patients with	41
were positive for	41
patients with mm	41
case of a	41
treatment option for	41
for more than	41
in this cohort	41
out of the	41
of the skin	41
cmv reactivation was	41
the start of	41
patients did not	41
secondary graft failure	41
the respiratory tract	41
in the second	41
can be considered	41
results indicate that	41
conditioning regimen for	41
reported in the	41
led to the	41
of breast milk	41
kg kg tag	41
infection and disease	41
with acute myeloid	41
patients at risk	41
months after transplant	41
prevention and treatment	41
is able to	40
varicella zoster virus	40
we hypothesize that	40
approved by the	40
hla class i	40
response to the	40
at the university	40
may result in	40
mechanism of action	40
the relationship between	40
and for the	40
purpose of this	40
and of patients	40
did not show	40
defined as the	40
diffuse large b	40
is required for	40
no statistically significant	40
in our institution	40
in the graft	40
patients diagnosed with	40
for up to	40
in our experience	40
and use of	40
sickle cell disease	40
the emergence of	40
the association between	40
treated with a	40
at this time	40
patients who have	40
in most cases	40
children and adults	40
group and in	40
overall survival and	40
was not significantly	40
the intensive care	40
are involved in	40
led to a	40
via breast milk	40
for the patients	40
on the outcome	40
remains to be	40
presence of a	40
of the ebmt	40
no effect on	40
a matched unrelated	40
of solid organ	40
our results suggest	40
infection in patients	40
and of the	40
of the t	39
related or unrelated	39
the last years	39
adoptive transfer of	39
of the literature	39
we report on	39
in the peripheral	39
a lack of	39
and function of	39
was to assess	39
in the donor	39
and risk factors	39
of cytomegalovirus infection	39
delta t cells	39
the patient had	39
associated with high	39
higher in patients	39
even in the	39
incidence of chronic	39
patients with an	39
these data suggest	39
in the lung	39
t cell development	39
was not associated	39
time of transplantation	39
patient with a	39
cyclophosphamide mg kg	39
their ability to	39
specific t cell	39
of severe acute	39
of acute rejection	39
were the most	39
be effective in	39
in this retrospective	39
immunoglobulin replacement therapy	39
member of the	39
be used for	39
with bone marrow	39
it may be	39
platelet engraftment was	39
was measured by	39
and it is	39
chronic gvhd were	39
lead to a	39
in the icu	39
hsct in our	39
were no differences	39
cd cells in	38
should not be	38
for the presence	38
mhc class ii	38
be related to	38
study of the	38
results in a	38
we demonstrated that	38
occurred in the	38
regimen consisted of	38
of death in	38
at a single	38
gvhd grade ii	38
may have a	38
the group of	38
than in the	38
to be an	38
cd cd t	38
donor lymphocyte infusion	38
a mean of	38
of the same	38
were performed using	38
impact of the	38
was based on	38
analyses were performed	38
of patients was	38
who underwent hsct	38
as a consequence	38
patients had received	38
no differences in	38
seem to be	38
days after hsct	38
performed a retrospective	38
and b cell	38
and the risk	38
development of a	38
was peripheral blood	38
risk factors and	38
with cmv reactivation	38
be used in	38
who underwent allo	38
class i molecules	38
at months after	38
overall survival of	38
majority of the	38
we describe a	38
from a matched	38
we compared the	38
was the only	37
was not statistically	37
due to its	37
patients were enrolled	37
in the high	37
relapsed or refractory	37
the potential to	37
respiratory tract infection	37
caused by a	37
no difference between	37
high dose chemotherapy	37
difference between the	37
was evaluated by	37
and the presence	37
in high risk	37
the formation of	37
differences between the	37
were excluded from	37
obtained from the	37
conditioning regimen and	37
the risk factors	37
the activity of	37
result in a	37
increased expression of	37
sinusoidal obstruction syndrome	37
considered as a	37
the appearance of	37
human herpes virus	37
conditioning regimens were	37
was a significant	37
results demonstrate that	37
were determined by	37
the control of	37
with evidence of	37
as high as	37
blood samples were	37
after solid organ	37
was similar in	37
t cells that	37
one patient developed	37
were enrolled in	37
is essential for	37
infection has been	37
this may be	37
first year after	37
effector t cells	37
of invasive aspergillosis	37
on the use	37
viral load in	37
nature of the	37
a year old	37
patients with cd	37
in patients treated	37
we showed that	37
at increased risk	37
mesenchymal stem cells	37
in the management	37
presence or absence	36
chronic graft versus	36
significantly higher than	36
cytomegalovirus disease in	36
was analyzed by	36
a myeloablative conditioning	36
of allogeneic stem	36
overall response rate	36
peripheral blood of	36
donor lymphocyte infusions	36
and fungal infections	36
after kidney transplantation	36
in lung transplantation	36
we studied the	36
a series of	36
in neutropenic patients	36
a role for	36
be explained by	36
are known to	36
is safe and	36
the response to	36
transplant recipients and	36
a reduced intensity	36
of b cell	36
of the infection	36
in line with	36
was shown to	36
among the patients	36
of pts with	36
in two patients	36
intensity conditioning regimen	36
important cause of	36
can result in	36
the patients received	36
of the transplant	36
to be more	36
red blood cells	36
bei patienten mit	36
were compared to	36
of gvhd and	36
as early as	36
and the patient	36
it should be	36
in the pre	36
cd cd cells	36
all patients engrafted	36
mutation in the	36
and mortality after	36
stem cell transplants	36
stem cells in	36
the study period	36
innate and adaptive	36
described in the	36
may be used	36
have to be	36
findings suggest that	36
than that of	36
been used in	36
to determine if	36
at least months	36
of human immunodeficiency	35
patients who did	35
as shown in	35
was supported by	35
of infectious diseases	35
for blood and	35
appear to be	35
the range of	35
in the regulation	35
were measured by	35
mg kg on	35
a mouse model	35
the entire cohort	35
resistant staphylococcus aureus	35
years after transplantation	35
bal fluid specimens	35
aim was to	35
which may be	35
of patients undergoing	35
performed in patients	35
combined immune deficiency	35
cells from the	35
there have been	35
in kidney transplant	35
overall survival in	35
between patients with	35
age at hsct	35
cytotoxic t cells	35
patients transplanted from	35
the cell surface	35
at one year	35
results show that	35
a statistically significant	35
the patients was	35
a subset of	35
lower in the	35
of hepatitis c	35
that have been	35
derived from the	35
it can be	35
immune response to	35
which can be	35
main cause of	35
systemic lupus erythematosus	35
moderate to severe	35
in the multivariate	35
in critically ill	35
activated t cells	35
were transplanted from	35
conditioning regimen consisted	34
disease caused by	34
liposomal amphotericin b	34
the site of	34
different time points	34
abstract already published	34
mouse model of	34
cytotoxic t lymphocytes	34
in the current	34
cmv reactivation and	34
could be used	34
in the pediatric	34
risk of gvhd	34
or in combination	34
of at least	34
to test the	34
days after the	34
in patients at	34
disease in the	34
in a multivariate	34
failure to thrive	34
b and t	34
similar to that	34
single center experience	34
heart and lung	34
cmv infection and	34
for disease control	34
the availability of	34
course of the	34
presence of the	34
patients with hematologic	34
has been suggested	34
adverse events were	34
mg kg d	34
age at diagnosis	34
patients transplanted with	34
time of days	34
may be considered	34
to increase the	34
a higher risk	34
efficacy of the	34
and at the	34
hsct in patients	34
the multivariate analysis	34
of the pts	34
a panel of	34
do not have	34
free survival was	34
the levels of	34
performed in the	34
of the cmv	34
of the illness	34
patient and graft	34
in a dose	34
is a well	34
and is associated	33
cells and the	33
with an average	33
in group a	33
children and adolescents	33
patients with the	33
reactivation of latent	33
significant differences between	33
the main cause	33
which is a	33
the diagnosis and	33
primary immune deficiency	33
of the clinical	33
infections of the	33
national institute of	33
was a trend	33
significant morbidity and	33
were reported in	33
of relapse was	33
the disease is	33
caused by the	33
risk of cmv	33
of the present	33
in both the	33
successfully treated with	33
we retrospectively reviewed	33
on behalf of	33
patients in cr	33
significant reduction in	33
a matched sibling	33
x cd cells	33
these results demonstrate	33
is defined as	33
and response to	33
the progression of	33
as a cause	33
and had a	33
a matched related	33
used to treat	33
been identified in	33
incidence of agvhd	33
b and c	33
the infectious diseases	33
length of stay	33
should be given	33
decrease in the	33
will be presented	33
in bal fluid	33
similar to those	33
history of recurrent	33
there is an	33
is due to	33
statistically significant difference	33
were divided into	33
event free survival	33
often associated with	33
of patients received	33
of the following	33
factors such as	33
similar to the	33
common in the	33
a member of	33
production of il	33
prospective study of	33
we report our	33
over the last	33
of them had	33
treatment of the	32
according to our	32
from bone marrow	32
a safe and	32
seen in patients	32
in accordance with	32
lower incidence of	32
treatment of cmv	32
the goal of	32
with a low	32
the result of	32
were identified as	32
been observed in	32
or in the	32
and to the	32
was significantly associated	32
in the past	32
correlated with the	32
should be performed	32
as opposed to	32
more frequent in	32
of regulatory t	32
severe aplastic anemia	32
who had received	32
in the recipient	32
overall survival at	32
was to investigate	32
respiratory viral infections	32
can be seen	32
a consequence of	32
is a frequent	32
leading cause of	32
showed a significant	32
alloreactive t cells	32
to elucidate the	32
cells and cd	32
patients undergoing hsct	32
we examined the	32
and development of	32
these patients were	32
with increased risk	32
to those of	32
we have shown	32
clinical manifestations of	32
mg twice daily	32
compared with those	32
are at risk	32
transplanted in cr	32
risk of graft	32
the contribution of	32
the efficacy and	32
treatment of patients	32
similar in both	32
cells can be	32
isolated from the	32
due to their	32
compared to non	32
of the lung	32
data with implanted	32
of consecutive patients	32
in this case	32
is not clear	32
virus infections in	32
is necessary to	32
of the graft	32
the likelihood of	32
characterized by a	32
patients with refractory	32
developed acute gvhd	32
of these infections	32
related mortality was	32
correlation between the	31
in the bone	31
acute myeloid leukaemia	31
cells of the	31
or bone marrow	31
could be a	31
in hsct patients	31
a trend for	31
for the detection	31
t cells by	31
is to evaluate	31
a high risk	31
an increase of	31
in any of	31
significantly different between	31
to healthy controls	31
with cmv infection	31
patients affected by	31
treatment related mortality	31
d and d	31
the application of	31
based on a	31
for the entire	31
transplantation in the	31
was to determine	31
here we present	31
by western blot	31
survival in patients	31
has been identified	31
consistent with the	31
is not a	31
in conjunction with	31
it is a	31
graft failure and	31
the most frequently	31
the evaluation of	31
shown in figure	31
to confirm the	31
all patients who	31
a child with	31
the early post	31
in some patients	31
a significant difference	31
of choice for	31
was to analyze	31
in situ hybridization	31
were tested for	31
consecutive patients with	31
differences were observed	31
no conflict of	31
with the exception	31
of hepatitis b	31
at the last	31
more than months	31
significant impact on	31
is shown in	31
were in cr	31
may play a	31
of cytomegalovirus disease	31
outcomes of patients	31
and type of	31
analysis showed that	31
as measured by	31
response to treatment	31
high level of	31
we aim to	31
next generation sequencing	31
were defined as	31
patients with mds	31
an attempt to	31
low incidence of	31
for high risk	31
present study was	31
bacterial and fungal	31
small number of	31
the timing of	31
an important cause	31
should be used	31
stem cells from	30
months after the	30
with primary immunodeficiency	30
the presence or	30
to be safe	30
in all groups	30
with implanted signals	30
the median of	30
cells in a	30
school of medicine	30
to of patients	30
chronic myeloid leukemia	30
this group of	30
acquired immunodeficiency syndrome	30
with acute gvhd	30
in patients transplanted	30
the diagnosis is	30
hematopoietic cell transplant	30
the nature of	30
treatment for patients	30
day and day	30
the hypothesis that	30
patients were diagnosed	30
identification of the	30
in a prospective	30
and quality of	30
be caused by	30
in allogeneic stem	30
majority of cases	30
peripheral blood and	30
after days of	30
and lung transplantation	30
been shown that	30
also been reported	30
of human herpesvirus	30
the kinetics of	30
conflicts of interest	30
tomato leaf curl	30
disease control and	30
to examine the	30
up to years	30
without evidence of	30
bone marrow cells	30
were analyzed for	30
cmv infection is	30
primary immunodeficiency diseases	30
and at years	30
increase the risk	30
be given to	30
colony stimulating factor	30
that patients with	30
in the post	30
percent of patients	30
identified in the	30
in vivo t	30
cd t lymphocyte	30
of cmv dna	30
t cell subsets	30
to the infant	30
the last decade	30
in human immunodeficiency	30
chronic gvhd in	30
our results show	30
many of the	30
determined by the	30
the mean age	30
has been observed	30
with hematologic malignancies	30
study was conducted	30
demonstrated that the	30
but it is	30
the immunocompromised host	30
cell dose was	30
therapy in the	30
used in patients	30
were performed with	30
the in vivo	30
at different time	30
was bone marrow	30
the release of	30
up of days	30
patients were followed	30
treatment of choice	30
serve as a	30
our study was	30
use of a	30
the innate immune	30
have been developed	30
no impact on	30
is a highly	30
the period of	30
survival at years	30
to understand the	30
the intensity of	30
wide range of	30
or unrelated donor	30
well as a	30
revealed that the	30
to define the	30
progressive multifocal leukoencephalopathy	30
within days after	29
conducted a retrospective	29
immunodeficiency virus type	29
in a significant	29
were in complete	29
of cmv pneumonia	29
of the total	29
patients compared to	29
patients with cancer	29
a crucial role	29
of these cells	29
the initiation of	29
university medical center	29
of infection and	29
with median age	29
for a median	29
be treated with	29
engraftment was achieved	29
the mechanisms of	29
a multivariate analysis	29
cd cells from	29
reduction of the	29
patients receiving a	29
ranging from to	29
t cell function	29
can be a	29
significant reduction of	29
that may be	29
control of the	29
of cmv in	29
as an alternative	29
the study is	29
of inkt cells	29
leads to a	29
with a mean	29
lead to the	29
cell transplantation from	29
national institutes of	29
associated with lower	29
the cells were	29
the group with	29
were conditioned with	29
factors for the	29
based on these	29
was in the	29
as soon as	29
were more likely	29
there has been	29
of the cells	29
had a significantly	29
statistical analysis was	29
the patients in	29
first complete remission	29
and in vitro	29
patients with pid	29
may be associated	29
is a potentially	29
the value of	29
in the immune	29
part of a	29
of patients treated	29
the performance of	29
supported by the	29
with a significant	29
were not significantly	29
higher rate of	29
we describe the	29
cmv reactivation in	29
received myeloablative conditioning	29
in the atg	29
after hsct and	29
regimen was myeloablative	29
the exception of	29
cell activation and	29
recipients of allogeneic	29
and months post	29
of acute graft	29
in the non	29
median dose of	29
is likely to	29
of relapse and	29
alone or in	29
and the development	29
from day to	29
and grade iii	29
to play a	29
which has been	29
were identified in	29
in the elderly	28
developed chronic gvhd	28
was given to	28
is a risk	28
t cells is	28
is a significant	28
cd cd foxp	28
cell proliferation and	28
and days after	28
vd t cells	28
mortality in the	28
in the spleen	28
centers for disease	28
in multiple myeloma	28
in the hsct	28
primary endpoint was	28
risk factors of	28
patients with non	28
on day was	28
between and were	28
enrolled in the	28
evaluate the impact	28
a high rate	28
might be a	28
did not respond	28
of patients at	28
and a median	28
be seen in	28
a reduction of	28
gvhd occurred in	28
patient had a	28
had no effect	28
was myeloablative in	28
year after hsct	28
time of diagnosis	28
age of patients	28
stem cells were	28
b cell lymphoma	28
after weeks of	28
signs and symptoms	28
an effective treatment	28
phase of the	28
was negative for	28
of the il	28
up to months	28
infection can be	28
older than years	28
to explore the	28
patients from the	28
institutes of health	28
data not shown	28
in relation to	28
reported to the	28
has the potential	28
were similar in	28
be responsible for	28
allogeneic hsct in	28
and the number	28
the patient and	28
pfs and os	28
working party of	28
to months after	28
patients with all	28
immunodeficiency virus infection	28
kg body weight	28
in clinical trials	28
of donor t	28
conditioning regimen with	28
one of them	28
samples from patients	28
in aids patients	28
the rest of	28
of patients receiving	28
of the major	28
consecutive patients who	28
to describe the	28
of age and	28
in liver transplant	28
a large number	28
increased in the	28
can be detected	28
data were collected	28
in the cd	28
transmission of hiv	28
which could be	28
and disease free	28
with relapsed refractory	28
of allogeneic hsct	28
regardless of the	28
the donor was	28
higher levels of	28
first months after	28
the loss of	28
associated with acute	28
world health organization	28
was identified in	28
found in patients	28
of adult patients	28
we used a	28
was obtained from	27
control and prevention	27
patients with cgd	27
a significant proportion	27
ranged from to	27
well tolerated and	27
in partial remission	27
prevention of cytomegalovirus	27
therapy for patients	27
increased incidence of	27
in up to	27
may be an	27
a significant decrease	27
for acute myeloid	27
who received an	27
the feasibility of	27
pts received a	27
in the mother	27
a key role	27
graft failure was	27
complete donor chimerism	27
and activation of	27
large cohort of	27
mg kg iv	27
clinical features of	27
significant proportion of	27
with at least	27
is feasible and	27
did not influence	27
party of the	27
to develop a	27
median time for	27
year after transplantation	27
also associated with	27
one case of	27
in the urine	27
of them received	27
during the period	27
was reported in	27
associated with significant	27
t cell depleted	27
male and female	27
in vivo and	27
of viral infection	27
a range of	27
in group b	27
cd b cells	27
the infusion of	27
detected in patients	27
none of these	27
the choice of	27
of renal function	27
hemorrhagic cystitis in	27
did not affect	27
with chronic gvhd	27
first year of	27
was added to	27
the characteristics of	27
to neutrophil engraftment	27
of immune suppression	27
patients transplanted in	27
and number of	27
after allogeneic sct	27
mg m d	27
data demonstrate that	27
two of them	27
early in the	27
the first years	27
the immune status	27
in the thymus	27
a high mortality	27
serum levels of	27
comparison of the	27
gvhd was observed	27
from matched unrelated	27
with the highest	27
be found in	27
it is also	27
medical records of	27
iga and igm	27
to characterize the	27
viral infections are	27
we developed a	27
t cell counts	27
the liver and	27
and lack of	27
source was peripheral	27
t cell lymphopenia	27
area under the	27
for hematologic malignancies	27
cell transplantation with	27
at day post	27
increased susceptibility to	27
in transplant patients	27
haploidentical hematopoietic stem	27
in all the	27
univariate and multivariate	27
groups of patients	27
were performed at	27
that of the	27
mainly due to	27
and platelet recovery	27
for pts with	27
considered in the	27
median time between	27
at any time	27
of primary immunodeficiency	27
bone marrow biopsy	27
in the remaining	27
a critical role	27
of the european	27
high rates of	27
with active disease	26
was referred to	26
absolute neutrophil count	26
un trasplante de	26
received a myeloablative	26
an incidence of	26
during this period	26
may be required	26
in first complete	26
of patients are	26
as stem cell	26
gvhd prophylaxis in	26
did not reach	26
with high dose	26
specific cytotoxic t	26
on the day	26
january and december	26
all but one	26
was due to	26
curative option for	26
is a curative	26
compared to a	26
based gvhd prophylaxis	26
age at transplantation	26
patients were alive	26
invasive pulmonary aspergillosis	26
complication of allogeneic	26
the distribution of	26
likely to have	26
de un trasplante	26
higher than that	26
no signs of	26
yellow fever virus	26
innate immune system	26
human immunodefi ciency	26
to neutrophil and	26
of infection with	26
a single dose	26
essential for the	26
compared with patients	26
in our patient	26
treatment of acute	26
to decrease the	26
in the table	26
only curative treatment	26
mg kg for	26
in those patients	26
insights into the	26
diagnosis of cmv	26
regimen consisting of	26
less likely to	26
between day and	26
stem cells transplantation	26
is mediated by	26
mg m on	26
the cases of	26
reduce the incidence	26
the extent of	26
the recovery of	26
to respond to	26
significantly increased in	26
in the t	26
in spite of	26
is needed to	26
surface expression of	26
are required to	26
compared to control	26
were detected by	26
regulation of the	26
test was used	26
poor graft function	26
or unrelated donors	26
compared to that	26
in these cases	26
can be found	26
autologous peripheral blood	26
acute gvhd in	26
the ci of	26
in the induction	26
at day after	26
infections caused by	26
et al reported	26
who presented with	26
retrospective chart review	26
natural history of	26
were assessed by	26
two patients had	26
of the innate	26
a wide range	26
and viral infections	26
the transcription factor	26
and patients were	26
and t cells	26
of the human	26
an analysis of	26
and review of	26
activity of the	26
in the skin	26
independent risk factors	26
one year after	26
reduction of immunosuppression	26
using flow cytometry	26
of immune reconstitution	26
function of the	26
old male with	26
with aml in	26
was to compare	26
low levels of	26
and there was	26
for use in	26
especially in the	26
report of the	26
we have developed	26
time of hsct	26
viral infections and	26
who received hsct	26
in stem cell	26
plays an important	26
the ratio of	26
of viral load	26
were transplanted with	26
b and nk	26
emerson et al	26
in aml patients	26
cd cells was	26
cd cd ra	26
en receptores de	26
os and dfs	26
immune response in	26
el tratamiento de	26
survival in the	26
the establishment of	25
median cd cell	25
median overall survival	25
at months was	25
indicate that the	25
used to assess	25
did not develop	25
between and at	25
chez les patients	25
the form of	25
be an effective	25
undergoing allogeneic hematopoietic	25
results of this	25
of immunosuppressive therapy	25
received peripheral blood	25
infected patients with	25
survival rate was	25
cord blood in	25
of the underlying	25
incidence of gvhd	25
the transplant recipient	25
in the incidence	25
influenza a virus	25
is limited by	25
in our centre	25
early diagnosis and	25
conditioning regimen in	25
plasma levels of	25
and patient survival	25
not differ between	25
t cells for	25
features of the	25
was complicated by	25
the potential of	25
allogeneic hsct recipients	25
transplant lymphoproliferative disorder	25
of t and	25
cells in vitro	25
mortality after allogeneic	25
lung transplant patients	25
to the treatment	25
significant differences were	25
the university hospital	25
of the current	25
due to an	25
primary and secondary	25
an average of	25
must be considered	25
be safe and	25
hsct from a	25
nk cells in	25
the underlying disease	25
had at least	25
b cells were	25
as a potential	25
the last follow	25
to detect the	25
nk cells and	25
most of these	25
aim of our	25
at and months	25
natural killer cells	25
cmv viral load	25
first days after	25
cells have been	25
data are available	25
significant difference was	25
to this end	25
sensitivity and specificity	25
more than days	25
of which were	25
high prevalence of	25
leading to a	25
in subjects with	25
caused by mutations	25
is also a	25
and total body	25
goal of this	25
all patients in	25
a minimum of	25
results showed that	25
the increase in	25
for diagnosis of	25
patient died of	25
have a high	25
time to platelet	25
group compared to	25
likely due to	25
der nachweis von	25
activated b cells	25
have been performed	25
were not different	25
by cd t	25
to identify patients	25
cytokine release syndrome	25
and autologous stem	25
patients had an	25
our understanding of	25
to of the	25
received an allogeneic	25
nothing to disclose	25
nk cells were	25
and reduced intensity	25
relapse or progression	25
transplant patients with	25
the development and	25
hla identical sibling	25
cells were isolated	25
and high risk	25
la incidencia de	25
associated with better	25
mortality in patients	25
for patients in	25
who do not	25
breast milk is	25
at diagnosis was	25
the same donor	25
added to the	25
it is unclear	25
most commonly used	25
the differential diagnosis	25
months post transplant	25
the cost of	25
urinary tract infections	25
compared to in	25
renal transplant recipient	25
to those with	25
leads to the	25
on the first	25
patients with and	25
peripheral blood was	25
the cd t	25
as determined by	25
at mg kg	25
flow cytometric analysis	25
and hematopoietic stem	25
is a safe	25
in elderly patients	25
of the anti	25
were stimulated with	25
of this approach	25
were significantly lower	25
of opportunistic infections	25
the prognosis of	25
pneumocystis jirovecii pneumonia	25
transmission of hepatitis	25
mild to moderate	25
especially in patients	25
who had undergone	25
who had a	25
identical sibling donor	25
cord blood transplant	25
not been reported	25
through breast milk	25
to establish the	25
patients after allogeneic	24
to the hospital	24
disease due to	24
in a small	24
infants and children	24
foxp t cells	24
in of them	24
in severe cases	24
high mortality rate	24
was performed at	24
in the period	24
by the use	24
during the course	24
patients died of	24
of treatment with	24
is related to	24
in a mouse	24
referred to as	24
transplant recipients are	24
parvovirus b infection	24
gvhd of the	24
recipients in the	24
these data indicate	24
cd t lymphocytes	24
between both groups	24
was not different	24
the natural history	24
after initiation of	24
suggesting that the	24
incidence and severity	24
in organ transplant	24
in renal transplantation	24
was admitted to	24
for acute leukemia	24
mobilized peripheral blood	24
it is possible	24
and treated with	24
previous studies have	24
between and in	24
be considered for	24
is seen in	24
cmv and ebv	24
acute gvhd of	24
contrast to the	24
associated with severe	24
and could be	24
at hsct was	24
to control the	24
the incidences of	24
transplantation in children	24
infection in children	24
disease has been	24
mg kg and	24
followed by the	24
i and ii	24
both cd and	24
in the field	24
during the last	24
of more than	24
cells as well	24
and treatment with	24
time of months	24
the total number	24
to the ebmt	24
to obtain a	24
may be seen	24
in an infant	24
the advent of	24
and associated with	24
year os and	24
the etiology of	24
the gi tract	24
is not well	24
after allogeneic bone	24
in the late	24
diseases such as	24
detection of cmv	24
these patients are	24
in vitro studies	24
had a significant	24
of bk virus	24
leading to the	24
its role in	24
mean age at	24
has resulted in	24
of the main	24
agents such as	24
are present in	24
could lead to	24
one of these	24
of bacterial infections	24
subset of patients	24
as shown by	24
a significant risk	24
are presented in	24
cumulative incidences of	24
society of america	24