This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.
| identifier | question |
|---|---|
| cord-009261-97qegnlo | The past or future of cancer treatment? |
| cord-000104-3b8b8p61 | How many different cytosolic sensors exist for nucleic acids? |
| cord-003656-7mzsaz7a | isolated from Struthio camelus Mycoplasmas and their host: emerging and re- emerging minimal pathogens Antibiotic residues in food: the African scenario DNA- antiviral vaccines: New developments and approaches- a review Immunization of animals: from DNA to the dinner plate DNA vaccines: an historical perspective and view to the future DNA vaccines: ready for prime time? |
| cord-000988-79fp75u3 | A communitybased outbreak of severe respiratory illness caused by human adenovirus serotype 14 Severe pneumonia due to adenovirus serotype 14: a new respiratory threat? |
| cord-002441-w731ehtz | The DNA- damage response in human biology and disease Regulation of DNA damage responses by ubiquitin and SUMO Ubiquitin and its kin: how close are the family ties? |
| cord-004515-x22q1f21 | Pregnancy or breast- feeding Opposition from the patient or his/ her relatives Protected major( Guardianship) Contraindication to the use of dornase alfa Known intolerance to dornase alfa Patient whose life expectancy is less than 24 h, according to the treating physician"Do not resuscitate"order Who will take informed consent? |
| cord-003207-ow3aez9v | Does the higher order structure of the influenza virus ribonucleoprotein guide sequence rearrangements in influenza viral RNA? |
| cord-004518-jd1wxobz | Raška, Milan title: DNA vaccines: are they still just a powerful tool for the future? |
| cord-000050-tfcerilc | Molecular determinants within the surface proteins involved in the pathogenicity of H5N1 influenza viruses in chickens Are we ready for pandemic influenza? |
| cord-007613-g4s0v8ra | Cytokines and HIV infection: is AIDS a tumour necrosis factor disease? |
| cord-009571-mygj2nd4 | Activation? |
| cord-007755-o2r8ktie | Can we infer peptide recognition specifi city mediated by SH3 domains? |
| cord-002966-9z350ucm | How good are my data and what is the resolution? |
| cord-000830-jiy4cp4n | Diagnostic molecular microbiology review Rapid enterovirus molecular testing in cerebrospinal fluid reduces length of hospitalization and duration of antibiotic therapy in children with aseptic meningitis Nucleic acid amplification and related techniques in microbiological diagnosis and epidemiology Molecular detection and quantitative analysis of the entire spectrum of human adenoviruses by a two- reaction real- time PCR assay Typing of human adenoviruses in specimens from immunosupressed patients by PCR- fragment length analysis and real- time quantitative PCR Monitoring of cytomegalovirus reactivation in bone marrow tranplant recipients by real- time PCR Comparison of commercial and in- house real- time PCR assays for quantification of Epstein- Barr virus( EBV) DNA in plasma Cytomegalovirus quantification: where to next in optimising patient management? |
| cord-004181-exbs3tz7 | The Journal of Infectious Diseases Development of Streptococcus agalactiae vaccines for tilapia Streptococcal β protein has separate binding sites for human factor h and IgA- Fc Identification of group B streptococcal Sip protein, which elicits cross- protective immunity Immunotherapy of established( pre)malignant disease by synthetic long peptide vaccines A web resource for designing subunit vaccine against major pathogenic species of bacteria Prospects for control of emergimg infectious dyseases with plasmid DNA vaccines DNA vaccines: ready for prime time? |
| cord-001090-qg2r691d | Diagnostic criteria and microbial and epidemiologic associations Effect of periodontal pathogens on the metatranscriptome of a healthy multispecies biofilm model Metatranscriptomic approach to analyze the functional human gut microbiota Composition of the Vaginal Microbiota in Women of Reproductive Age-Sensitive and Specific Molecular Diagnosis of Bacterial Vaginosis Is Possible? |
| cord-001859-d62iuk72 | The second potentially druggable heat shock protein and molecular chaperone? |
| cord-007757-4mri8kyq | Duchenne muscular dystrophy and the neuromuscular junction: the utrophin link Mouse models of human genetic disease: which mouse is more like a man? |
| cord-003945-esnyjoq5 | Learn more biomedcentral.com/submissions Ready to submit your research? |
| cord-010621-d1utt8j3 | Why are allergies increasing? |
| cord-009376-a35a92gh | Different real- time PCR formats compared for the quantitative detection of human cytomegalovirus DNA Human exposure to bovine polyomavirus: a zoonosis? |
| cord-010037-1bpc8g6n | really evolutionary dead- ends( again)? |
| cord-000765-r7y1cqou | The prospect for bacteriophage therapy in Western medicine Population and evolutionary dynamics of phage therapy Bacteriophage therapy- cooked goose or phoenix rising? |
| cord-000765-r7y1cqou | rediscovery and renewed assessment of potential Phage therapy- advantages over antibiotics? |
| cord-007382-5kb16qb7 | T cells Human deoxyribonucleases STING- dependent cytosolic DNA sensing pathways CRISPR provides acquired resistance against viruses in prokaryotes A developmentally regulated activity that unwinds RNA duplexes An unwinding activity that covalently modifies its double- stranded RNA substrate Toll- like receptor 9 processing: The key event in Toll- like receptor 9 activation? |
| cord-007382-5kb16qb7 | The ribonuclease activity of SAMHD1 is required for HIV-1 restriction Trashing the genome: The role of nucleases during apoptosis Approaching the RNA ligand for RIG- I? |
| cord-014908-jys1y0k9 | derivative bearing[ Os(5,6-dimethyl-1,10-phenanthroline)2Cl]2? |
| cord-001761-yvd1n42f | Recent developments in microwave- assisted protein chemistries- can this be integrated into the drug discovery and validation process? |
| cord-001761-yvd1n42f | Why was RCA with four heat- stable DNA polymerases accelerated by microwave heating, although the overall reaction temperatures were the same? |
| cord-013837-x95r6bz8 | This finding one to wonder why a mycobacteria departs from a cozy niche to enter the cytosol where it must confront a series of cytosolic immune sensors? |
| cord-012418-6ralcn8p | Related Compounds Inhibition of virus multiplication by foreign nucleic acid Approaching the asymptote? |
| cord-014875-xhzxhwgo | Where does this lead us? |
| cord-007047-7ty9mxa9 | 2 high- risk HPV DNA testing Occurrence and documentation of low- level bacteremia in a community hospital's patient population Comparison of 9 different PCR primers for the rapid detection of severe acute respiratory syndrome coronavirus using 2 RNA extraction methods Comparison of six DNA extraction methods for recovery of fungal DNA as assessed by quantitative PCR Rapid diagnosis of tuberculous meningitis: what is the optimal method? |
| cord-007047-7ty9mxa9 | Diminishing racial disparities in early- onset neonatal group B streptococcal disease- United States Discovering new pathogens: culture- resistant bacteria Etiology of acute pharyngitis in children: is antibiotic therapy needed? |
| cord-001072-pjv3wy80 | Microneedle technologies for( trans)dermal drug and vaccine delivery Techniques of tissue handling and transfer Intradermal vaccine delivery: will new delivery systems transform vaccine administration? |
| cord-001072-pjv3wy80 | effects of dosage and route on safety and immunogenicity Electroporation as a"prime/ boost"strategy for naked DNA vaccination against a tumor antigen Vaxfectin- formulated influenza DNA vaccines encoding NP and M2 viral proteins protect mice against lethal viral challenge DNA vaccines: ready for prime time? |
| cord-010511-eoc0ex3i | Do these findings obtained in murine models correlate with human disease? |
| cord-010511-eoc0ex3i | Extensive accumulation of eosinophil extracellular traps in bullous delayed- pressure urticaria: a pathophysiological link? |
| cord-002844-jv42o789 | Chromatin remodeling, histone modifications, and DNA methylation- how does it all fit together? |
| cord-002844-jv42o789 | is the eIF4E cap- binding factor required for viral mRNA translation? |
| cord-002687-ql6zo8ka | : what should be the goal for new therapies? |
| cord-002687-ql6zo8ka | Novel mechanism of antibodies to hepatitis B virus in blocking viral particle release from cells Processing of X- ray diffraction data collected in oscillation mode Crosstalk between human IgG isotypes and murine effector cells Antiviral monoclonal antibodies: can they be more than simple neutralizing agents? |
| cord-004501-guiy89x8 | Up to now we have concluded that current antiviral therapy has not yet achieved the ideal shape and efficiency and also that the complex biological barriers are major obstacles, but can we critically say that nanotechnology could be the identified solution? |
| cord-004501-guiy89x8 | Viral pneumonia La Revue de Médecine Interne Viral myocarditis Viral infections in type 1 diabetes mellitus- Why the β cells? |
| cord-011073-uiabpbxd | of`free'DNA in PCRbased assays Development of fluorogenic probe- based PCR assays for the detection and quantification of bovine piroplasmids Influence of the biotope on the tick infestation of cattle and on the tick- borne pathogen repertoire of cattle ticks in Ethiopia PCR- based pooling of dried blood spots for detection of malaria parasites: optimization and application to a cohort of Ugandan children Development of a multiplex loop- mediated isothermal amplification( mLAMP) method for the simultaneous detection of bovine Babesia parasites Bovine theileriosis-an emerging problem in south- eastern Australia? |
| cord-000937-8vk89i4h | A novel DNA virus( TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology TT- virus infection in North American blood donors, patients with fulminant hepatic failure, and cryptogenic cirrhosis TT viruses: oncogenic or tumorsuppressive properties? |
| cord-000937-8vk89i4h | clusters of orthologous genes and reconstruction of viral genome evolution GB virus C replicates in primary T and B lymphocytes GB virus type C/ hepatitis G virus: a non- pathogenic flavivirus associated with prolonged survival in HIV- infected individuals GB virus C: the good boy virus? |
| cord-014712-5u4e00q6 | DO WE STAND NOW? |
| cord-015935-r2wd1yfa | Meeting at the synapse? |
| cord-001111-qqmj4v0u | After all, should n't cultured cells and cells in live animals have similar, if not exactly the same, genomic organization and transcriptional machinery? |
| cord-001111-qqmj4v0u | can cause dilated cardiomyopathy Is green fl uorescent protein toxic to the living cells? |
| cord-010680-lc1onm53 | Advances in mRNA vaccines for infectious diseases Administration of nucleoside- modified mRNA encoding broadly neutralizing antibody protects humanized mice from HIV-1 challenge In vivo gene delivery by nonviral vectors: overcoming hurdles? |
| cord-010680-lc1onm53 | The making of bispecific antibodies Therapeutic antibody discovery in infectious diseases using single- cell analysis Beyond natural antibodies: the power of in vitro display technologies Advances in recombinant antibody manufacturing Developability index: a rapid in silico tool for the screening of antibody aggregation propensity Five computational developability guidelines for therapeutic antibody profiling Industrialization of mAb production technology: the bioprocessing industry at a crossroads Monoclonal antibodies: magic bullets with a hefty price tag Pricing of monoclonal antibody therapies: higher if used for cancer? |
| cord-004675-n8mlxe7p | ; and whether the information is actionable( clinical utility)? |
| cord-004675-n8mlxe7p | ; whether a given variant is causative( pathogenicity)? |
| cord-004675-n8mlxe7p | Through the sharing of genetic and health data, ClinGen seeks to answer whether a given gene is associated with a disease( clinical validity)? |
| cord-005281-wy0zk9p8 | CRISPR/ Cas systems Cpf1 is a single RNA- guided endonuclease of a class 2 CRISPR- Cas system How many antiviral small interfering RNAs may be encoded by the mammalian genomes? |
| cord-005281-wy0zk9p8 | Can viruses make us human? |
| cord-005281-wy0zk9p8 | The next genetics revolution? |
| cord-015941-4fz79wzf | Comparison of a commercial IgM capture ELISA with dengue antigen focus reduction microneutralization test and the centers for disease control dengue IgM capture- ELISA PCR detection of nearly any dengue virus strain using a highly sensitive primer cocktail Do babesiosis and malaria share a common disease process? |
| cord-017838-fbotc479 | The failed HIV Merck vaccine study: a step back or a launching point for future vaccine development? |
| cord-010500-ajmj2hyj | What is the causal basis for the low levels of MHC polymorphism among the moose analysed in this study? |
| cord-010500-ajmj2hyj | a tale of incest, pestilence and sexual preference DNA'fingerprinting'reveals high levels of inbreeding in colonies of the eusocial naked mole- rat Genetic variation and differentiation in Scandinavian moose( Alces alces): are large mammals monomorphic? |
| cord-016304-uusmg786 | a review Using a pan- viral microarray assay( Virochip) to screen clinical samples for viral pathogens Cancer gene expression signatures- the rise and fall? |
| cord-017563-jkhvcjcb | PTEN-coupling tumor suppression to stem cells? |
| cord-000293-pc4x5e24 | A mechanical explanation of RNA pseudoknot function in programmed ribosomal frameshifting Progress in antisense technology Morpholino oligos: making sense of antisense? |
| cord-000293-pc4x5e24 | The global structures of a wild- type and poorly functional plant luteoviral mRNA pseudoknot are essentially identical Correlation between mechanical strength of messenger RNA pseudoknots and ribosomal frameshifting Interaction of the HIV-1 frameshift signal with the ribosome Characterization of the mechanical unfolding of RNA pseudoknots Locked nucleic acid oligonucleotides: the next generation of antisense agents? |
| cord-000293-pc4x5e24 | towards clinical reality Antisense technology: a selective tool for gene expression regulation and gene targeting Chemical modification: the key to clinical application of RNA interference? |
| cord-005400-50lmj4op | But why was the mortality rate so high? |
| cord-005400-50lmj4op | Would it be possible to repeat this outstanding success with another infectious disease? |
| cord-005400-50lmj4op | immunizations Is global measles eradication feasible? |
| cord-017752-ofzm3x3a | A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma Is cancer dangerous to the immune system? |
| cord-018145-kssjdn8y | Intracellular immunization: a new strategy for producing diseaseresistant transgenic livestock? |
| cord-014597-66vd2mdu | : Comparability study from Process Performance to Product Quality Attributes Maximizing binding capacity for protein A chromatography Protein Glycosylation and its Role in Protein Folding Afucosylated antibodies increase activation of FcγRIIIa- dependent signaling components to intensify processes promoting ADCC Sialic Acids and other Nonulosonic Acids Production of antibody in insect cells Suitability and perspectives on using recombinant insect cells for the production of virus- like particles Cloning of cDNA and characterization of anti- RNase A monoclonal antibody 3A21 Production of functional antibody Fab fragment by recombinant insect cells Optimization of HEK-293S cell cultures for the production of adenoviral vectors in bioreactors using on- line OUR measurements Enhancing heterologous protein expression and secretion in HEK293 cells by means of combination of CMV promoter and IFNα2 signal peptide HEK293 cell culture media study towards bioprocess optimization: animal derived component free and animal derived component containing platforms Comparison of control strategies for fed- batch culture of hybridoma cells based on on- line monitoring of oxygen uptake rate, optical cell density and glucose concentration Continuous bioprocessing: The real thing this time? |
| cord-014597-66vd2mdu | Eliminating canine rabies, the principal source of human infection: What will it take? |
| cord-000012-p56v8wi1 | Science Are there bugs in our genome? |
| cord-000012-p56v8wi1 | The genome of Melanoplus sanguinipes entomopoxvirus Cloning and expression of a gene encoding a Campoletis sonorensis polydnavirus structural protein A gene encoding a polydnavirus structural polypeptide is not encapsidated What does structure tell us about virus evolution? |
| cord-000012-p56v8wi1 | redox considerations for HIV and SARS- coronavirus Genetic recombination of the DNA plant virus PBCV-1 in a chlorella alga Common origin of four diverse families of large eukaryotic DNA viruses Evolutionary genomics of nucleo- cytoplasmic large DNA viruses Effects of the nonoccluded virus of Spodoptera frugiperda( Lepidoptera: Noctuidae) on the development of a parasitoid Parasitoid- mediated transmission of an iridescent virus Non- poly- DNA viruses, their parasitic wasp, and hosts The few virus- like genes of Cotesia congragata Self- synthesizing DNA transposons in eukaryotes Marvericks, a novel class of giant transposable elements widespread in eukaryotes and related to DNA viruses Evolution of viruses by acquisition of cellular RNA or DNA nucleotide sequences and genes: an introduction Microbialgenes in the human genome: lateral transfer or gene loss? |
| cord-003764-141u6ax7 | How Far From Clinical Use? |
| cord-003764-141u6ax7 | The structural basis for membrane binding and pore formation by lymphocyte perforin DNA vaccines and apoptosis: to kill or not to kill? |
| cord-003764-141u6ax7 | What if? |
| cord-010056-zfin4bko | Intestinal absorption of vitamin B12 in man Intestinal absorption of vitamin B12 in humans as studies by isotope technic Bacterial communities in the small intestine respond differently to those in the caecum and colon in mice fed low- and high- fat diets Small intestinal bacterial overgrowth and irritable bowel syndrome: a bridge between functional organic dichotomy Small intestinal bacterial overgrowth and other intestinal disorders Systematic genome assessment of B- vitamin biosynthesis suggests co- operation among gut microbes Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations • fast, convenient online submission Ready to submit your research? |
| cord-010056-zfin4bko | The InterPro protein families database: the classification resource after 15 years Identifying biologically relevant differences between metagenomic communities Drivers of microbiome biodiversity: a review of general rules, feces, and ignorance Microbiomic analysis of the bifidobacterial population in the human distal gut Exploring the diversity of the bifidobacterial population in the human intestinal tract Host- microbe interactions that facilitate gut colonization by commensal bifidobacteria Diversity of bifidobacteria within the infant gut microbiota Interaction of probiotics and pathogens- benefits to human health? |
| cord-017948-fqhl1qb4 | Emerging infectious disease agents and their potential threat to transfusion safety Detection of prion infection in variant Creutzfeldt- Jakob disease: a blood- based assay Threat of dengue to blood safety in dengue- endemic countries PCR detection of nearly any dengue virus strain using a highly sensitive primer cocktail Do babesiosis and malaria share a common disease process? |
| cord-017867-8cn4c6cu | A simple and rapid method for staining Tritrichomonas foetus and Trichomonas vaginalis Comparison of growth rates of Tritrichomonas foetus isolates from various geographic regions using three different culture media Are Tritrichomonas foetus and Tritrichomonas suis synonyms? |
| cord-016309-6mw8okmt | Combination chemotherapy: interaction of 5-methoxymethyldeoxyuridine with adenine arabinoside, 5-ethyldeoxyuridine, 5-iododeoxyuridine, and phosphonoacetic acid against herpes simplex virus types 1 and 2 Single- chain fragment variable antibody against the capsid protein of bovine immunodeficiency virus and its use in ELISA Cham Bracklein T et al( 2006) Activity of feline interferon- omega after ocular or oral administration in cats as indicated by Mx protein expression in conjunctival and white blood cells High- content screening in infectious diseases History and progress of antiviral drugs: from acyclovir to directacting antiviral agents( DAAs) for Hepatitis C Natural products to drugs: natural product- derived compounds in clinical trials Efficacy, toxicology and clinical applications of ribavirin against virulent RNA viral infections Synthesis and antiviral evaluation of trisubstituted indole N- nucleosides as analogues of 2, 5, 6-trichloro-1-(β- D- ribofuranosyl) benzimidazole( TCRB) Expression and characterization of a recombinant porcinized antibody against the E2 protein of classical swine fever virus Drug repurposing: new treatments for zika virus infection? |
| cord-016309-6mw8okmt | Synthesis and antiviral activity Is AZT/3TC therapy effective against FIV infection or immunopathogenesis? |
| cord-018526-rz7id5mt | a highly efficient, lipid- mediated DNA- transfection procedure Mechanism of oligonucleotide release from cationic liposomes Cellular and molecular barriers to gene transfer by a cationic lipid Nuclear import of plasmid DNA in digitoninpermeabilized cells requires both cytoplasmic factors and specific DNA sequences Improvement of exogenous DNA nuclear importation by nuclear localization signal- bearing vectors: a promising way for non- viral gene therapy? |
| cord-011030-o4jn5883 | Multicenter study of banked third- party virus- specific T cells to treat severe viral infections after hematopoietic stem cell transplantation Off- the- shelf virus- specific T cells to treat BK virus, human herpesvirus 6, cytomegalovirus, Epstein- Barr virus, and adenovirus infections after allogeneic hematopoietic stem- cell transplantation Long- term control of recurrent or refractory viral infections after allogeneic HSCT with third- party virus- specific T cells Adoptive immunotherapy of viral infections: should infectious disease embrace cellular immunotherapy? |
| cord-011030-o4jn5883 | Why did maribavir fail in stem- cell transplants? |
| cord-011030-o4jn5883 | a randomized, double- blind, multicenter controlled trial Maribavir and human cytomegaloviruswhat happened in the clinical trials and why might the drug have failed? |
| cord-016187-58rqc0cg | -The lessons of SARS Public health measures to control the spread of the severe acute respiratory syndrome during the outbreak in Toronto Multistate outbreak of monkeypox- Illinois Westward HO? |
| cord-016187-58rqc0cg | -The spread of West Nile virus Death from the Nile crosses the Atlantic: The West Nile fever story Hemorrhagic fever viruses as biological weapons Death due to bioterrorism- related anthrax: Report of two patients Isolation and partial molecular characterization of a strain of Ebola virus during a recent epidemic of viral haemorrhagic fever in Gabon Staphylococcus aureus resistant to Vancomycin- United States Oseltamivir- resistant infl uenza? |
| cord-016751-g46gs087 | ihre Geschichte? |
| cord-016751-g46gs087 | wagte sich der Mensch erstmals aus den ihm bekannten afrikanischen Jagdgründen in unerforschtes Land? |
| cord-013412-gj443yei | Is antimicrobial resistance a slowly emerging disaster? |
| cord-013412-gj443yei | The G- Quadruplex/ Helicase World as a Potential Antiviral Approach against COVID-19 Targets and tools in antiviral therapy G- quadruplexes in pathogens: A common route to virulence control? |
| cord-013412-gj443yei | Type III Photochemical Mechanism? |
| cord-000452-1gd006zy | Electroporation of synthetic DNA antigens offers protection in nonhuman primates challenged with highly pathogenic avian influenza virus Intradermal vaccine delivery: will new delivery systems transform vaccine administration? |
| cord-000452-1gd006zy | What happens if intradermal injections of rabies vaccine are partially or entirely injected subcutaneously? |
| cord-000452-1gd006zy | fabrication, mechanics and transdermal drug delivery Polymer microneedles for controlled- release drug delivery Jet gun or syringe? |
| cord-000452-1gd006zy | using microneedles induces superior protection to intramuscular immunization Cellular and humoral immune responses induced by intradermal or intramuscular vaccination with the major hepatitis B surface antigen Randomized controlled clinical trial of fractional doses of inactivated poliovirus vaccine administered intradermally by needle- free device in Cuba Clinical safety and efficacy of a powdered hepatitis B nucleic acid vaccine delivered to the epidermis by a commercial prototype device Intradermally administered yellow fever vaccine at reduced dose induces a protective immune response: a randomized controlled non- inferiority trial Intradermal vaccination to protect against yellow fever and influenza Penetration- enhanced ultrasharp microneedles and prediction on skin interaction for efficient transdermal drug delivery Induction of antigen- specific CD8? |
| cord-017999-saxwqc2j | How might this change in flexibility be effected? |
| cord-017999-saxwqc2j | To what extent are variations in DNA flexibility reflected in genomic organisation? |
| cord-018944-du42ho11 | do we stand? |
| cord-016313-n4ewq0pt | Neuroprotective effect of combined hypoxia- induced VEGF and bone marrowderived mesenchymal stem cell treatment Complete knockdown of CCR5 by lentiviral vector- expressed siRNAs and protection of transgenic macrophages against HIV-1 infection Speci fi c transduction of HIV- susceptible cells for CCR5 knockdown and resistance to HIV infection: a novel method for targeted gene therapy and intracellular immunization Stem cells and reprogramming: breaking the epigenetic barrier? |
| cord-016313-n4ewq0pt | TGF{beta}/ TNF{alpha}-mediated epithelial- mesenchymal transition generates breast cancer stem cells with a claudin- low phenotype Genetically engineered mesenchymal stem cells: applications in spine therapy Hyaluronan and mesenchymal stem cells: from germ layer to cartilage and bone Notch signaling as gatekeeper of rat acinar- to- beta- cell conversion in vitro Transplantation of human bone marrow- derived mesenchymal stem cells promotes Will there be a live- attenuated HIV vaccine available for human safety trials by the year 2000? |
| cord-018046-jzoykn0y | A template- free method towards conducting polymer nanostructures Bottom- up synthesis and sensor applications of biomimetic nanostructures Synthesis and characterization of water- soluble and bifunctional ZnO- Au nanocomposites Bottom- up and top- down approaches to the synthesis of monodispersed spherical colloids of low melting- point metals Molecular self- assembly and nanochemistry: a chemical strategy for the synthesis of nanostructures Self- assembled polymer nanostructures for delivery of anticancer therapeutics Controlled synthesis of ZnO nanowires or nanotubes via sol- gel template process Shape- controlled synthesis of metal nanocrystals: simple chemistry meets complex physics? |
| cord-018046-jzoykn0y | reinventing the wheel? |
| cord-018039-dw2xblyr | Higher environmental relative moldiness index values measured in homes of adults with asthma, rhinitis or both conditions Indoor bacteria and asthma in adults: a multicenter case- control study within ECRHSII Microbial content of household dust associated with exhaled NO in asthmatic children Dampness and 2-ethyl-1-hexanol in floor construction of rehabilitation center: health effects in staff Chloroanisoles may explain mold odor and represent a major indoor environment problem in Sweden Microbial volatile organic compounds- what substances can be found in sick buildings? |
| cord-018039-dw2xblyr | Sensory irritation potency of some microbial volatile organic compounds( MVOCs) and a mixture of five MVOCs Relevance of airborne fungi and their secondary metabolites for environmental, occupational and indoor hygiene Determination of selected microbial volatile organic compounds by diffusion sampling and dual- column capillary GC- FID- a new feasible approach for the detection of an exposure to indoor mould fungi? |
| cord-013223-f43hks44 | A human gut microbial gene catalogue established by metagenomic sequencing Are we really vastly outnumbered? |
| cord-013223-f43hks44 | The biology, function, and biomedical applications of exosomes Current understanding of the human microbiome Membrane vesicle release in bacteria, eukaryotes, and archaea: a conserved yet underappreciated aspect of microbial life Virulence and immunomodulatory roles of bacterial outer membrane vesicles Extracellular vesicle RNA: a universal mediator of microbial communication? |
| cord-013223-f43hks44 | The healthy human blood microbiome: fact or fiction? |
| cord-010027-r0tl01kq | Are Current Automated Approaches for Determining the Phylogeny of Multiple Deposits Capable of Interpreting the Complexity of Cancer Evolution? |
| cord-010027-r0tl01kq | Should I keep the brain? |
| cord-010027-r0tl01kq | Yet? |
| cord-010027-r0tl01kq | Molecular Pathology: The Future? |
| cord-025232-5itrsfmk | A community- derived outbreak of adenovirus type 3 in children in Taiwan between Molecular identification and epidemiological features of human adenoviruses associated with acute respiratory infections in hospitalized children in Southern China Comparative genomic analysis of re- emergent human adenovirus type 55 pathogens associated with adult severe communityacquired pneumonia reveals conserved genomes and capsid proteins Adenoviral infections in Singapore: should new antiviral therapies and vaccines be adopted? |
| cord-006860-a3b8hyyr | ( platelet count< I50/~L) or a relative decrease in platelet count(? |
| cord-006860-a3b8hyyr | The examination reveals, that Fg- Au was present in a low density on the platelet surface, in higher density in the surface connected system( SCS), in coated pits and vesicles and separated smooth vesicles( representing endosomes?) |
| cord-006860-a3b8hyyr | The superpositisn of hepatitis infections on the treatment with blood and native blood products in most of the cases has let unanswered the question related to the mechanism of the immunodeficiency: the hepatitis B or C infections or the negative impact of the itarative important alloantigenlc load? |
| cord-023369-xwclh6ih | Serological evidence for congenital transmission of human herpesvirus 6 Examination of human breast milk for evidence of human herpesvirus 6 by polymerase chain reaction Human herpesvirus 6 and neuroinflammation Human herpesvirus-6 entry into the central nervous system through the olfactory pathway Association of human herpesvirus 6 infection of the central nervous system with recurrence of febrile convulsions Human herpesvirus 6 DNA in cerebrospinal fluid specimens from allogeneic bone marrow transplant patients: does it have clinical significance? |
| cord-018437-yjvwa1ot | The size and conformation of Kaposi's sarcoma- associated herpesvirus( human herpesvirus 8) DNA in infected cells and virions Characterization of a novel coronavirus associated with severe acute respiratory syndrome Nucleotide sequence of the Kaposi sarcoma- associated herpesvirus( HHV8) Human bocavirus: passenger or pathogen in acute respiratory tract infections? |
| cord-018437-yjvwa1ot | What does virus evolution tell us about virus origins? |
| cord-015850-ef6svn8f | A compromise solution to the introns- early versus introns- late debate? |
| cord-015850-ef6svn8f | The evolution of spliceosomal introns: Patterns, puzzles and progress Genes in pieces: Were they ever together? |
| cord-015850-ef6svn8f | What kind of the relationship exists between the genome size and mutation rates? |
| cord-015850-ef6svn8f | Why genes in pieces? |
| cord-006466-e1phpqes | ; Full- body magnetic resonance imaging demonstrates generalized lymphadenomegaly and hepatosplenomegaly; PET- CT showing signs of hypoperfusion in temporal( right), occipital and cerebellum regions( suggestive of hypoperfusion-vasculitis?) |
| cord-006466-e1phpqes | A( p.=?) of unknown significance and a MEFV heterozygous variant. |
| cord-006466-e1phpqes | Acute pneumonia? |
| cord-006466-e1phpqes | Moderate diffuse changes in the renal parenchyma( toxic- inflammatory?). |
| cord-020235-stcrozdw | Are the sites of insertion of viral DNA specific? 2. |
| cord-020235-stcrozdw | What type of recombinatorial events occur in viral DNA integration? |
| cord-018969-0zrnfaad | Where have all the bees gone? cord-018969-0zrnfaad What Is Causing CCD? cord-027654-k0uby99n SIVmacinduced immunodefi ciency AAV vectors: is clinical success on the horizon? cord-015933-x5cq4k4x -= niet werkzaam;? cord-015933-x5cq4k4x : heeft de patiënt met hoge koorts die net terug is uit de tropen malaria of niet, is er bij een kind met hoofdpijn en koorts sprake van een hersenvliesontsteking? cord-015933-x5cq4k4x maakt hij een zieke indruk of is er sprake van malaise, is de patiënt alert of juist verward en minder goed aanspreekbaar? cord-020969-lh2ergpm A look to future directions in gene therapy research for monogenic diseases Update on adenovirus and its vectors Herpes simplex virus 1( HSV-1) for cancer treatment Virus vectors and their applications The use of oncolytic vaccinia viruses in the treatment of cancer: A new role for an old ally? cord-020969-lh2ergpm In addition, the expression needs to continue for the life of the patient, which means either a very stable( integrated?) cord-014685-ihh30q6f How important is protein exibility for transport through ion channels? cord-014685-ihh30q6f Should it be the autonomous course or the part of physiology and radiology courses in the problem based learning approach?! cord-014685-ihh30q6f The consistency in the formations of these conformations makes the design of peptides with alpha, beta? cord-014685-ihh30q6f a tug- ofwar or coordinated movement? cord-026518-xv03vpji A single electroporation delivery of a DNA vaccine containing the hemagglutinin gene of Asian H5N1 avian influenza virus generated a protective antibody response in chickens against a North American virus strain Electric pulses applied prior to intramuscular DNA vaccination greatly improve the vaccine immunogenicity Impact of chicken- origin cells on adaptation of a low pathogenic influenza virus Newcastle disease virus: is an updated attenuated vaccine needed? cord-022336-zqnczjpp Circular RNAs: relics of precellular evolution? cord-022336-zqnczjpp viroids escaped introns? cord-010443-4jblod8j Are statins analogues of Vitamin D? cord-010443-4jblod8j NF- κB activation by TNF via the activation of p38 mitogen- activated protein kinase Vitamin C suppresses TNFα- induced NFκB activation by inhibiting IκBα phosphorylation Ascorbate protects against vascular leakage in cecal ligation and puncture- induced septic peritonitis Glucocorticosteroids as adjunctive therapy for acute respiratory distress syndrome and sepsis? cord-010443-4jblod8j Why do we need nongenomic glucocorticoid mechanisms? cord-010443-4jblod8j an evolutionary medicine perspective Stress- induced glucocorticoids as a neuroendocrine alarm signal of danger Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis Long- term host immune response trajectories among hospitalized patients with sepsis Protracted immune disorders at one year after ICU discharge in patients with septic shock Inflammation versus glucocorticoids as purveyors of pathology during stress: have we reached the tipping point? cord-010443-4jblod8j and decreases ROS and MCP-1 and IL-8 secretion in high- glucose exposed U937 monocytes 25-Dihydroxyvitamin D3 regulates mitochondrial oxygen consumption and dynamics in human skeletal muscle cells Improving the Vitamin D status of Vitamin D deficient adults is associated with improved mitochondrial oxidative function in skeletal muscle Vitamin D kinetics in the acute phase of critical illness: a prospective observational study When not to use meta- analysis: analysing the meta- analyses on Vitamin D in critical care Effect of high- dose Vitamin D3 on hospital length of stay in critically ill patients with Vitamin D deficiency: the VITdAL- ICU randomized clinical trial Is vitamin C beneficial to patients with CAP? cord-024149-qnclsjym success and limitations Shifts in bacterial community structure associated with inputs of low molecular weight carbon compounds to soil Bacterial dehalogenases: biochemistry, genetics and biotechnological applications Towards an ecological classification of soil bacteria Multiresistance and tolerance in microbial biofilms Stabilizing mechanisms in legume- rhizobium mutualism Impact of culture- independent studies on the emerging phylogenetic view of bacterial diversity Bioremediation: techniques for cleaning up a mess Fertiliser contaminants in New Zealand grazed pasture with special reference to cadmium and fluorine: a review Microbial heavy metal resistance When do arbuscular mycorrhizal fungi protect plant roots from pathogens? cord-023830-w218ogsk Nucleic acid approaches for detection and identification of biological warfare and infectious disease agents Detection of respiratory viruses and subtype identification of influenza A viruses by GreeneChipResp oligonucleotide microarray Panmicrobial oligonucleotide array for diagnosis of infectious diseases Microarray technology: the future of blood testing? cord-026729-hn0q0sbv Thus, a future study aiming to explore the molecular mechanisms underlying intrinsic correlation between TASs( e.g., CcdAB), SOS response, and persister formation will enhance our understanding of the persistence phenomenon in EcN. Toxin- antitoxin systems, the potential regulator in EcN for bacterial interference? cord-033054-qaj1f6qq Do we really need prognostic factors for breast cancer? cord-015683-a9a82of4 How are the proteomic assays helpful in aiding diagnostics? cord-015683-a9a82of4 How has the advancement in biotechnological techniques helped in diagnosis of the diseases? cord-015683-a9a82of4 What is MALDI- TOF? cord-015683-a9a82of4 What is the importance of PCR in pathogen detection? cord-028729-vhpuvp4g : where do we come from, where do we go to? cord-018371-16zhx0ai ( Reversibility:?) cord-018371-16zhx0ai ( Reversibility:?) cord-018371-16zhx0ai ( Reversibility:?) cord-018371-16zhx0ai ( Reversibility:?) cord-023208-w99gc5nx Are aza- β3 amino acids γ- turn mimetics? cord-023208-w99gc5nx These cells were multilayered on day-3 and expressed various keratinocyte markers, including cytokeratin-1, involculin, and laminin? cord-004948-ad3i9wgj A dummy or a protagonist on the stage of inflammation? cord-004948-ad3i9wgj A dummy or a protagonist on the stage of inflammation? cord-004948-ad3i9wgj Brain α- endosulfine is manifold decreased in brains from patients with Alzheimer's disease: a tentative marker? and drug target? cord-004948-ad3i9wgj Brain α- endosulfine is manifold decreased in brains from patients with Alzheimer's disease: a tentative marker? and drug target? cord-004948-ad3i9wgj The initial question that interested us was what makes a di/ tri- peptide a substrate, but not an amino acid? cord-004948-ad3i9wgj Why are we interested in this? cord-025251-evnfvc0l Inhaled therapeutics for prevention and treatment of pneumonia Rapid- response vaccines- does DNA offer a solution? cord-025251-evnfvc0l influenza virus infection Lung epithelial GM- CSF improves host defense function and epithelial repair in influenza virus pneumonia- a new therapeutic strategy? cord-031565-mos619wp Can multiple- copy sequences of prey DNA be detected amongst the gut contents of invertebrate predators? cord-004879-pgyzluwp A50$ 14- 28 Neutralization rates of TNF- a from eight animal species by a monoclonal antibody against human TNF: implication for receptor action? cord-004879-pgyzluwp Are these two activities encoded by a single mRNA? cord-004879-pgyzluwp Do their protein- chemical structure and organisation decipher us certain clues and parts of the path by which they have been selected and derived from a possible primordial reaction centre polypeptide? cord-004879-pgyzluwp Does the ALEP1 germ- line specific protein have a homologue in the somatic ribosomes? cord-004879-pgyzluwp However, in the presence of 1000 U/ ml interferon? cord-004879-pgyzluwp Is membranebound enzyme preferentially associated with a given cellular membrane? cord-004879-pgyzluwp What is the function of rpS 19? cord-014397-7b88ycv8 A sialoglycopeptide from human erythrocytes with receptor- like properties for encephalomyocarditis and influenza viruses Resistance in transgenic tobacco plants expressing a nonstructural gene sequence of tobacco mosaic virus is a consequence of markedly reduced virus replication Does the beta- andrenergic factor receptor function as reovirus receptor? cord-014397-7b88ycv8 Determinants essential for the transmissible gastroenteritis virus receptor interaction reside within a domain of aminopeptidase N that is distinct from the enzymatic site Molecular characterization of gene- for- gene systems in plant fungus interactions and the application of avirulence genes in control of plant pathogens Risk assessment: do we let history repeat itself? cord-014397-7b88ycv8 Plant viral resistance Will transgenic crops generate new viruses and new diseases? cord-014397-7b88ycv8 The mammalian cell- virus relationship Attachment of poliovirus to cultivated cells of primate and nonprimate origin Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily Binding to sialic acids is not an essential step for entry of animal rotaviruses to epithelial cells in culture Genetic exchange between bacteriophage T4 and filamentous fungi? cord-014397-7b88ycv8 Why did certain mechanisms develop and others not? cord-103563-7a3wdduq do hollow networks form in a polycrystalline infinite nanoplane by the Kirkendall effect? cord-103892-v6gkubd4 Since the TL folding can account only for a fraction of the inhibitory effect, what other factors make the 2'-endo conformers of 2'dNTPs catalytically inert? cord-104321-fpoztmcl Is the amelogenin gene reliable for gender identification in forensic casework and prenatal diagnosis? cord-023592-w96h4rir tigecycline the answer? cord-023928-9a1w174h Given the tens of thousands of genes in the human genome and the millions of genetic polymorphisms, on which polymorphisms and in which genes should investigators focus? cord-023928-9a1w174h I LLN ESS severity between two children with pneumonia be associated with variations in their genes coding for one of the surfactant proteins? cord-023928-9a1w174h In considering this possibility, which of the following is true? cord-016713-pw4f8asc ( review) Pathogen recognition and development of particulate vaccines: does size matter? cord-016713-pw4f8asc : what are the benefits for the elderly? cord-016713-pw4f8asc I( IGF- I) Immunogenicity in mice of a cationic microparticle- adsorbed plasmid DNA encoding Japanese encephalitis virus envelope protein Vaccine potential of cytosolic proteins loaded fibrin microspheres of Cryptococcus neoformans in BALB/ c mice Plasmid DNA loaded chitosan nanoparticles for nasal mucosal immunization against hepatitis B Comparing the effect of IL-12 genetic adjuvant and alum non- genetic adjuvant on the efficiency of the cocktail DNA vaccine containing plasmids encoding SAG-1 and ROP-2 of Toxoplasma gondii Nasal immunization with plasmid DNA encoding P6 protein and immunostimulatory complexes elicits nontypeable Haemophilus influenzaespecific long- term mucosal immune responses in the nasopharynx Nanoparticles as carriers for nasal vaccine delivery DNA vaccines: ready for prime time? cord-016713-pw4f8asc basic studies and applications Immune responses against a new HIV-1 p24-gp41/ pCAGGS- IL-12 DNA vaccine in Balb/ c mice Enhancement of cellular immune response to a prostate cancer DNA vaccine by intradermal electroporation Live attenuated AIDS viruses as vaccines: promise or peril? cord-016713-pw4f8asc human immunodeficiency virus type 1 Anionic PAMAM dendrimers rapidly cross adult rat intestine in vitro: a potential oral delivery system? cord-004534-jqm1hxps -Single molecule biophysics- Is there a specific erythrocyte membrane receptor for fibrinogen? cord-004534-jqm1hxps A generalized quantitative FRAP method with no restriction on the size of the photobleached area Heterochromatin protein 1 in DNA damage response-recruitment or dissociation from repair sites? cord-004534-jqm1hxps Application of the methodology to binding of various aromatic drugs with DNA provides an answer to the question'What forces are the main contributors to the stabilization of aromatic ligand- DNA complexes'? cord-004534-jqm1hxps Do retinal rod outer segments carry out oxydative phosphorylation? cord-004534-jqm1hxps Does the lysosomal membrane need triglycerides? cord-004534-jqm1hxps What about the force? cord-004534-jqm1hxps pN. Pushing on microtubules: dominant spindle centering mechanism in C. elegans embryo? cord-252147-bvtchcbt Is declining innovation in the pharmaceutical industry a myth? cord-009615-xcz8m9a7 An electron microscopic study Are astrocytes infected in progressive multifocal leukoencephalopathy( PML)? cord-009615-xcz8m9a7 Can they also be accommodated by a latent- virus model? cord-009615-xcz8m9a7 Could brain infection with a latent virus capable of limited reactivation in glial cells explain this wealth of data? cord-009615-xcz8m9a7 Is it time to change the paradigm? cord-009615-xcz8m9a7 Sclerose en plaques et gliome cerebral Glioblastoma associated with multiple sclerosis: Coincidence or induction? cord-009615-xcz8m9a7 The development of rational strategies for selective immunotherapy against autoimmune demyelinating disease T cell vaccination in multiple sclerosis: A preliminary report Multiple sclerosis: Additional thoughts Debate: Do TCR genes influence susceptibility to autoimmune disease in humans? cord-009615-xcz8m9a7 What would determine whether a latent virus infection remains entirely benign, or erupts as a chronic demyelinating disease such as MS? cord-019050-a9datsoo Ductal epithelial proliferations of the breast: A biologic continuum? cord-019050-a9datsoo Exploiting the potential of gene expression profiling: Is it ready for the clinic? cord-019050-a9datsoo Gene expression profiling: Does it add predictive accuracy to clinical characteristics in cancer prognosis? cord-019050-a9datsoo How can the specificity of the experiment be controlled? cord-252536-gfx4cq03 Gene therapy for obesity? cord-023120-jcgf2401 Filled-s represent mWA8 and pro&? cord-023120-jcgf2401 In addition to these patterns, we&? cord-023120-jcgf2401 both fragments are rich in hydrophobic amino acids, but? cord-023120-jcgf2401 events? cord-022177-j0qcjbxg Sequenzierung der Genome von Tieren gewonnen? cord-022177-j0qcjbxg Was ist mit den übrigen Genen? cord-022177-j0qcjbxg all dessen Gene zum Leben unentbehrlich? cord-022177-j0qcjbxg der Fotografie dargestellt ist, und dem Vorgang der Translation mit Polysomen( 7 Abb. 14.15)? cord-104030-eb29t38n If aging indeed impacts Treg cell- mediated recovery, is it a Treg cell- autonomous phenomenon or is it because the aging lung microenvironment is resistant to Treg cell- mediated repair? cord-104030-eb29t38n What are the molecular mechanisms underpinning the age- associated Treg cell gain or loss- of pro- reparative function in the lung following influenza infection? cord-023727-ahbnchj9 Is NotSimple"? |
| cord-023727-ahbnchj9 | Why does the genotype not congeal? |
| cord-023727-ahbnchj9 | o n Event, a n d H o w M u c h is Necessary? |
| cord-016588-f8uvhstb | Are we measuring the right thing? |
| cord-016588-f8uvhstb | Estimating phenotypic drug resistance from HIV-1 genotypes Mycobacterium du jour: what's on tomorrow's menu? |
| cord-016588-f8uvhstb | How do we compare hundreds of bacterial genomes? |
| cord-016588-f8uvhstb | Mauve: multiple alignment of conserved genomic sequence with rearrangements Harnessing bioinformatics to discover new vaccines Integration of omics data: how well does it work for bacteria? |
| cord-016588-f8uvhstb | Microb Infect Ten years of bacterial genome sequencing: comparative- genomics- based discoveries Integration and mining of malaria molecular, functional and pharamacological data: how far are we from a chemogenomic knowledge space? |
| cord-016588-f8uvhstb | What would you do if you could sequence everything? |
| cord-102661-lh7992rl | -Transgenic Rodent Somatic and Germ Cell Gene Mutation Assays, adopted 26 Genotoxicity and Carcinogenicity Testing of Pharmaceuticals Mutation as a toxicological endpoint for regulatory decision- making A compendium of mutational signatures of environmental agents Detection of ultra- rare mutations by next- generation sequencing Enhancing the accuracy of next- generation sequencing for detecting rare and subclonal mutations Highthroughput sequencing in mutation detection: A new generation of genotoxicity tests? |
| cord-102661-lh7992rl | For example, what would define the optimal subset of the genome to be used for drug and chemical safety testing? |
| cord-253115-ekgdsv4f | In vivo tumor targeting via nanoparticlemediated therapeutic siRNA coupled to inflammatory response in lung cancer mouse models Novobrantseva, siRNA and the lung: research tool or therapeutic drug? |
| cord-103735-nil1vv6h | A pneumonia outbreak associated with a new coronavirus of probable bat origin The SARS, MERS and novel coronavirus( COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? |
| cord-103735-nil1vv6h | Cold Spring Harb Surveillance of wild birds for avian influenza virus Chances and limitations of wild bird monitoring for the avian influenza virus H5N1-detection of pathogens highly mobile in time and space African swine fever epidemic Tracking zoonotic pathogens using blood- sucking flies as'flying syringes Empty forests, empty stomachs? |
| cord-252302-qi9dtaow | A perpective of traditional methods and biosensors Advances towards integrated bioelectron systems for environmental molecular microbiology Nucleic acid- based detection of bacterial pathogens using integrated microfluidic platform systems Detection and identification of biological threat agents in environmental samples Detecting and responding to bioterrorism Principles and Practice of Infectious Diseases Clinical recognition and management of patients exposed to biological warfare agents Microbial characterization during composting of biowaste Chemical sensors: A global market report Point- of- care testing of proteins Microfluidics for Biological Applications Agroterrorism: Where are we in the ongoing war on terrorism? |
| cord-252302-qi9dtaow | Scaling Principles and Asymptonic Analysis Digital microfluidics: Is a true lab- on- a- chip possible? |
| cord-013415-110b95cg | Critical events in the pathogenesis of periodontitis? |
| cord-013415-110b95cg | Die by Apoptosis or Survive in a Senescence- Like State? |
| cord-013415-110b95cg | Gingival fibroblasts resist apoptosis in response to oxidative stress in a model of periodontal diseases LPS- induced premature osteocyte senescence: Implications in inflammatory alveolar bone loss and periodontal disease pathogenesis Senescence and apoptosis: Dueling or complementary cell fates? |
| cord-013415-110b95cg | Repeated lipopolysaccharide stimulation promotes cellular senescence in human dental pulp stem cells( DPSCs) Effect of lipopolysaccharides on adipogenic potential and premature senescence of adipocyte progenitors Telomeres, oxidative stress and inflammatory factors: Partners in cellular senescence? |
| cord-013415-110b95cg | Role of the Aggregatibacter actinomycetemcomitans Cytolethal Distending Toxin in Oral Infectious Disease Do bacterial genotoxins contribute to chronic inflammation, genomic instability and tumor progression? |
| cord-013415-110b95cg | What happens to those healthy cells that reside in this harmful environment? |
| cord-013415-110b95cg | cord-013415- 110b95cg authors: Aquino- Martinez, Ruben; Khosla, Sundeep; Farr, Joshua N.; Monroe, David G. title: Periodontal Disease and Senescent Cells: New Players for an Old Oral Health Problem? |
| cord-255536-x1z2o9gs | Targeting G- quadruplexes in gene promoters: a novel anticancer strategy? |
| cord-023844-3flfngu0 | Wie sollte der eigene Arbeitsplatz aussehen? |
| cord-023844-3flfngu0 | Wie sollte man arbeiten? |
| cord-023844-3flfngu0 | unweigerlich die Frage stellen würde: » Wozu machst du das dann überhaupt? |
| cord-023844-3flfngu0 | «? |
| cord-253894-4u5yt7b7 | Assuming the latter scenario, what is the acquired new function of the poxvirus F16 homologs? |
| cord-017817-ztp7w9yh | Bacteria, the endoplasmic reticulum and the unfolded protein response: friends or foes? |
| cord-017817-ztp7w9yh | Endocytosis and autophagy: exploitation or cooperation? |
| cord-017817-ztp7w9yh | How can this be? |
| cord-017817-ztp7w9yh | Such"ROS- induced ROS release"might permit small ROS signals generated by mitochondria to activate ROS signalling throughout the cell, thereby avoiding mitochondrial damage that might arise if the entire cellular oxidant signal originated from that organelle[ 83]( or even leading to excessive ROS production?). |
| cord-017817-ztp7w9yh | What's the damage? |
| cord-017817-ztp7w9yh | an essential component of universal oxygen sensing machinery? |
| cord-027865-p1epjn51 | ( FKHR) gene break- apart by fluorescence in situ hybridization in formalin- fixed, paraffin- embedded alveolar rhabdomyosarcomas and its clinicopathologic correlation In situ hybridization: a review of methodologies and applications in the biomedical sciences Three- color fluorescence in situ hybridization for the simultaneous detection of multiple nucleic acid sequences Numerical chromosome aberrations in bladder cancer detected by in situ hybridization Molecular testing? |
| cord-027865-p1epjn51 | So, the question arises, why not just do IHC? |
| cord-027865-p1epjn51 | Two major choices must be made for the preparation of a probe: • What type of nucleic acid is to be used( DNA or RNA, single or double stranded)? |
| cord-027865-p1epjn51 | What type of label is to be incorporated into the probe? |
| cord-258623-9evwcs32 | That is, is topology of the DNAzyme important for binding of hemin or the actual oxidation of peroxidase substrates or both? |
| cord-030369-4dn02a35 | If the strict definition of acute and subacute liver failure as"no past history of liver disease"is executed, how to name the patients who had a history of chronic liver disease( caused by HBV from mother to child transmission in China)? |
| cord-030369-4dn02a35 | When should"I"consider a new hepatitis B virus genotype? |
| cord-030369-4dn02a35 | is tenofovir the answer? |
| cord-016293-pyb00pt5 | : Is There Ample Evidence? |
| cord-016293-pyb00pt5 | According to anecdotal evidence when visiting his namesake centre, Sanger asked:"What does this machine do then?""Dideoxy sequencing"came the reply, to which Fred retorted:"Have n't they come up with anything better yet?" |
| cord-016293-pyb00pt5 | According to anecdotal evidence when visiting his namesake centre, Sanger asked:"What does this machine do then?""Dideoxy sequencing"came the reply, to which Fred retorted:"Have n't they come up with anything better yet?" |
| cord-016293-pyb00pt5 | Issues of justice and resource allocation also have been raised: In a time of strain on our health care system, can we afford such expensive therapy? |
| cord-016293-pyb00pt5 | That finding led plant pathologist Roger Beachy, then at Washington University in Saint Louis, to wonder exactly how such"cross- protection"worked-did part of the virus prompt it? |
| cord-016293-pyb00pt5 | When Steve Fodor was asked in 2003"How do you really take the Human genome sequence and transform it into knowledge?" |
| cord-016293-pyb00pt5 | Who should receive gene therapy? |
| cord-260422-z22t57ju | a cysteine- rich peptide mimics the normal metal- linked dimer interface Fuzzy complexes: a more stochastic view of protein function HIV-1 Tat, apoptosis and the mitochondria: a tubulin link? |
| cord-259738-yuqc6dk0 | Selective in vitro growth of T lymphocytes from normal human bone marrows DNA vaccines: back in the saddle again? |
| cord-258035-2tk7maqk | Drosophila cells Role for a bidentate ribonuclease in the initiation step of RNA interference Evidence that siRNAs function as guides, not primers, in the Drosophila and human RNAi pathways ATP requirements and small interfering RNA structure in the RNA interference pathway Phenotypic silencing of cytoplasmic genes using sequence- specific double- stranded short interfering RNA and its application in the reverse genetics of wild type negative- strand RNA viruses Short interfering RNA confers intracellular antiviral immunity in human cells siRNA- directed inhibition of HIV-1 infection Modulation of HIV-1 replication by RNA interference Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference RNA interference directed against viral and cellular targets inhibits human immunodeficiency virus type 1 replication Selective silencing of viral gene expression in HPV- positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs RNA interference: the new somatic cell genetics? |
| cord-258035-2tk7maqk | The future of cancer management: translating the genome, transcriptome, and proteome Long- term infection and transformation of dermal microvascular endothelial cells by human herpesvirus 8 Kaposi's sarcoma- associated herpesvirusinduced upregulation of the c- kit proto- oncogene, as identified by gene expression profiling, is essential for the transformation of endothelial cells Altered patterns of cellular gene expression in dermal microvascular endothelial cells infected with Kaposi's sarcoma- associated herpesvirus Inhibition of c- kit receptor tyrosine kinase activity by STI 571, a selective tyrosine kinase inhibitor Gene silencing in mammals by small interfering RNAs Morpholino oligos: making sense of antisense? |
| cord-261417-4pf5nsw2 | Noncoding RNA- guided recruitment of transcription factors: A prevalent but undocumented mechanism? |
| cord-253826-63dgq551 | ( RDT) Use and limitations of light microscopy for diagnosing malariaattheprimaryhealthcarelevel Fluorescence versus conventional sputum smear microscopy for tuberculosis: a systematic review Microscopy as a diagnostic tool in pulmonary tuberculosis Diagnosis of urinary tract infection in children: fresh urine microscopy or culture? |
| cord-253826-63dgq551 | Why do we have so many definitions for nanoscience and nanotechnology? |
| cord-256130-zhlvvuj4 | Are we there yet? |
| cord-259748-x7dq1sy4 | interferon response reduces microglial reactivity and neuroinflammation Modulation of the immune system by UV radiation: more than just the effects of vitamin D? |
| cord-014368-4nasrbs6 | A typical search asks a question such as"What can be found out about the negative regulatory aspects of a genetic network in the pharynx?" |
| cord-014368-4nasrbs6 | But how realistic is this venture? |
| cord-014368-4nasrbs6 | But why stop there? |
| cord-014368-4nasrbs6 | If you have ever spent an evening hoisting brews with your pals at the corner pub, chances are you never stopped to think- gee, how do I lift my glass now that it's only half full? |
| cord-014368-4nasrbs6 | Running the same search three times on three different subsets of content might be better than running it 15 times- but would n't it be easier to run it just once? |
| cord-014368-4nasrbs6 | So naturally, neuroscientists wonder, does the architectural organization of the motor system reveal an underlying functional organization? |
| cord-014368-4nasrbs6 | The question is, how soon can these levels be achieved for biology? |
| cord-014368-4nasrbs6 | The question is, how soon can these levels be achieved for biology? |
| cord-259929-02765q5j | Driving the Scalability of DNA- Based Information Storage Systems Big data, but are we ready? |
| cord-259929-02765q5j | Machines Smarter Than Men? |
| cord-260345-ugd8kkor | ( 1992) H ow does photodynamic therapy work? |
| cord-260345-ugd8kkor | ~e growth factor? |
| cord-270637-4zphlpks | Toxicity of antiretroviral nucleoside and nucleotide analogues: is mitochondrial toxicity the only mechanism? |
| cord-253295-82ydczid | ( diagnosis),"how it going to behave?" |
| cord-253295-82ydczid | ( prognosis), and"how do I treat it?" |
| cord-253295-82ydczid | Pathologists collect the data needed to answer patients'and clinicians'questions, simply phrased as"what is it?" |
| cord-260705-huyyw5z6 | How do viruses interact with stress- associated RNA granules? |
| cord-260705-huyyw5z6 | Virus factories: Associations of cell organelles for viral replication and morphogenesis A guide to viral inclusions, membrane rearrangements, factories, and viroplasm produced during virus replication Virus factories, double membrane vesicles and viroplasm generated in animal cells Aggresomes and pericentriolar sites of virus assembly: Cellular defense or viral design? |
| cord-265764-h4zg0q8x | Shrinking the malaria map: progress and prospects Thousands of chemical starting points for antimalarial lead identification Artemisinin resistance in Plasmodium falciparum malaria Malaria chemotherapeutics, part I: history of antimalarial drug development, currently used therapeutics, and drugs in clinical development Hybrid molecules with a dual mode of action: dream or reality? |
| cord-267714-ji88tvsl | The Century Foundation'Are bioterrorism dollars making us safer? |
| cord-017297-q3qtgrfc | A ring- opening mechanism for DNA binding in the central channel of the T7 helicase- primase protein Polypyrimidine- tract- binding protein is a component of the HCV RNA replication complex and necessary for RNA synthesis Helicase inhibition by anthracycline anticancer agents Specific interaction of hepatitis C virus protease/ helicase NS3 with the 3-terminal sequences of viral positive- and negative- strand RNA Host defense, viruses and apoptosis Opening of nucleic- acid double strands by helicases: active versus passive opening Helicases: a unifying structural theme? |
| cord-017297-q3qtgrfc | Does NTP binding alter the enzyme's affinity for nucleic- acid binding? |
| cord-017297-q3qtgrfc | Does the enzyme interact with only one strand of the nucleic acid or both? |
| cord-017297-q3qtgrfc | N7-chloroethyl- guanosine N9-chloroethyl- guanosine Competitive activation of helicase Feedback inhibition by ssNA? |
| cord-017297-q3qtgrfc | Why are these interactions with the cellular factors important? |
| cord-017297-q3qtgrfc | binding by the enzyme could help answer questions like: does the enzyme require a single- stranded region to initiate unwinding? |
| cord-017297-q3qtgrfc | the case of hepatitis C Structure of the replicative helicase of the oncoprotein SV40 large tumour antigen Mechanochemistry of t7 DNA helicase Use of an in vitro model and yeast two- hybrid system to investigate the pathogenesis of hepatitis C Quick guide: DEAD- box proteins Are DEAD- box proteins becoming respectable helicases? |
| cord-018737-1h84yi2i | A live attenuated Listeria monocytogenes vaccine vector expressing SIV Gag is safe and immunogenic in macaques and can be administered repeatedly Heterologous prime- boost immunizations with different Salmonella serovars for enhanced antigen- specific CD8 T- cell induction Development of a live and highly attenuated Listeria monocytogenes- based vaccine for the treatment of Her2/ neuoverexpressing cancers in human Live recombinant Salmonella typhi vaccines constructed to investigate the role of rpoS in eliciting immunity to a heterologous antigen Recombinant Bacillus subtilis spores expressing MPT64 evaluated as a vaccine against tuberculosis in the murine model Construction and screening of attenuated?? |
| cord-018737-1h84yi2i | A live attenuated Listeria monocytogenes vaccine vector expressing SIV Gag is safe and immunogenic in macaques and can be administered repeatedly Heterologous prime- boost immunizations with different Salmonella serovars for enhanced antigen- specific CD8 T- cell induction Development of a live and highly attenuated Listeria monocytogenes- based vaccine for the treatment of Her2/ neuoverexpressing cancers in human Live recombinant Salmonella typhi vaccines constructed to investigate the role of rpoS in eliciting immunity to a heterologous antigen Recombinant Bacillus subtilis spores expressing MPT64 evaluated as a vaccine against tuberculosis in the murine model Construction and screening of attenuated?? |
| cord-018737-1h84yi2i | impact of malnutrition with preservation of cytokine secretion Salmonella enterica serovar typhimurium vaccine strains expressing a nontoxic shigalike toxin 2 derivative induce partial protective immunity to the toxin expressed by enterohemorrhagic escherichia coli Protective immunity against Clostridium difficile toxin A induced by oral immunization with a live, attenuated Vibrio cholerae vector strain In vivo expression and immunoadjuvancy of a mutant of heat- labile enterotoxin of Escherichia coli in vaccine and vector strains of Vibrio cholerae Development of a?? |
| cord-018737-1h84yi2i | impact of malnutrition with preservation of cytokine secretion Salmonella enterica serovar typhimurium vaccine strains expressing a nontoxic shigalike toxin 2 derivative induce partial protective immunity to the toxin expressed by enterohemorrhagic escherichia coli Protective immunity against Clostridium difficile toxin A induced by oral immunization with a live, attenuated Vibrio cholerae vector strain In vivo expression and immunoadjuvancy of a mutant of heat- labile enterotoxin of Escherichia coli in vaccine and vector strains of Vibrio cholerae Development of a?? |
| cord-018737-1h84yi2i | now and forever Induction of protective cellular immunity against Mycobacterium tuberculosis by recombinant attenuated selfdestructing Listeria monocytogenes strains harboring eukaryotic expression plasmids for antigen 85 complex and MPB/ MPT51 Immune responses to Bacillus Calmette- Guerin vaccination: why do they fail to protect against mycobacterium tuberculosis? |
| cord-018737-1h84yi2i | that express antigens from enterotoxigenic Escherichia coli Bacterial virulence, proinflammatory cytokines and host immunity: how to choose the appropriate Salmonella vaccine strain? |
| cord-017188-d3xg05ty | Do the diamagnetic( decomposition or transformed) products of a spin trap adduct accumulate to sufficient levels for detection by NMR? |
| cord-017188-d3xg05ty | Does the resultant NMR spectrum allow extrapolation back to a specific radical adduct? |
| cord-017188-d3xg05ty | In vivo evidence of free radical formation in the rat lung after exposure to an emission source air pollution particle Consequences of nitric oxide generation in epileptic- seizure rodent models as studied by in vivo EPR Is the vulnerability of neurons in the substantia nigra of patients with Parkinson's disease related to their neuromelanin content? |
| cord-017188-d3xg05ty | Is cocoa the best beverage? |
| cord-017188-d3xg05ty | The retinal pigmented epithelium is required for development and maintenance of the mouse neural retina Cell- free hemoglobin limits nitric oxide bioavailability in sicklecell disease Low levels of reactive oxygen species as modulators of cell function How many mutations are required for tumorgenesis? |
| cord-017188-d3xg05ty | The roles of neuromelanin, binding of metal ions, and oxidative cytotoxicity in the pathogenesis of Parkinson's disease: a hypothesis Is the incidence of registrable age- related macular degeneration increasing? |
| cord-017188-d3xg05ty | What's the use of generating melanin? |
| cord-266670-jxgywvwx | New mosaic subgenotype of varicella- zoster virus in the USA: VZV detection and genotyping by oligonucleotidemicroarray Genotyping of hepatitis B virus( HBV) by oligonucleotides microarray Protecting public health from the impact of body- contact recreation Towards a unified system for detecting waterborne pathogens Manual of Clinical Microbiology Seasonal distribution of adenoviruses, enteroviruses and reoviruses in urban river water Experimental evaluation of the FluChip diagnostic microarray for influenza virus surveillance Community outbreak of adenovirus type 7a infections associated with a swimming pool United Nations Educational, Scientific and Cultural Organizations Identification of a novel gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant Hearing on Meeting the Nation's Wastewater Infrastructure Needs Incidence of adenoviruses in raw and treated water Prevalence, quantification and typing of adenoviruses detected in river and treated drinking water in South Africa Environmental Protection Agency water quality guidelines for recreational waters prevent gastrointestinal illness? |
| cord-271241-w1q46y63 | Can We Contain the COVID-19 Outbreak With the Same Measures as for SARS? |
| cord-023095-4dannjjm | ABSTRACT E-60 DOES CEFQUINOME PENETRATE THE BLOOD BRAIN BARRIER IN THE NORMAL HORSE? |
| cord-263570-6notzm6s | A real- time PCR assay for rapid detection and quantitation of canine parvovirus type 2 DNA in the feces of dogs Genotyping- specific fluorogenic RT- PCR assays for the detection and quantitation of canine coronavirus type I and II RNA in faecal samples of dogs Infectious canine hepatitis: an"old"disease reemerging in Italy Characterisation of the canine parvovirus type 2 variants using minor groove binder probe technology First detection of canine parvovirus type 2c in pups with haemorrhagic enteritis in Spain Tissue distribution of the antigenic variants of canine parvovirus type 2 in dogs Canine parvovirus infection: which diagnostic test for virus? |
| cord-263570-6notzm6s | Do canine parvoviruses affect canine neurons? |
| cord-272579-aenuyht0 | the nucleolus- a gateway to viral infection? |
| cord-267733-fuz8r3vj | The world health organization and global smallpox eradication Vaccinia virus transcription Vaccinia virus vectors: New strategies for producing recombinant vaccines Poxvirus genome evolution by gene gain and loss Poxvirus cell entry: How many proteins does it take? |
| cord-011053-gza05hsv | : What is Aspergillus? |
| cord-011053-gza05hsv | An outbreak of colistinresistant Klebsiella pneumoniae carbapenemase- producing Klebsiella pneumoniae in the Netherlands Actionable diagnosis of neuroleptospirosis by next- generation sequencing Identification of prosthetic joint infection pathogens using a shotgun metagenomics approach Chronic meningitis investigated via metagenomic next- generation sequencing A human gut microbial gene catalogue established by metagenomic sequencing Optimisation and benchmarking of targeted amplicon sequencing for mycobiome analysis of respiratory specimens Bacterial genome sequencing in the clinic: bioinformatic challenges and solutions Engineering bioinformatics: building reliability, performance and productivity into bioinformatics software Accelerating in silico research with workflows: a lesson in simplicity Tissue penetration of antifungal agents Drug- drug interactions of antifungal agents and implications for patient care Azole resistance in Aspergillus fumigatus: a side- effect of environmental fungicide use? |
| cord-011053-gza05hsv | Antifungal resistance: current trends and future strategies to combat Species identification and antifungal susceptibility testing of Candida bloodstream isolates from population- based surveillance studies in two U.S. cities from Risk factors for fluconazole- resistant invasive candidiasis in intensive care unit patients: an analysis from the China Survey of Candidiasis study Epidemiology of candidemia and antifungal susceptibility in invasive Candida species in the Asia- Pacific region Azole resistance in Aspergillus fumigatus: can we retain the clinical use of mold- active antifungal azoles? |
| cord-011053-gza05hsv | In addition, Malassezia may induce cutaneous inflammation via a Th-17 response, with increased CCR6? |
| cord-011053-gza05hsv | Response to fungal dysbiosis by gut- resident CX3CR1? |
| cord-011053-gza05hsv | Skin fungal community and its correlation with bacterial community of urban Chinese individuals Effect of an emollient on the mycobiome of atopic dermatitis patients A fungal world: could the gut mycobiome be involved in neurological disease? |
| cord-011053-gza05hsv | The human lung and Aspergillus: You are what you breathe in? |
| cord-011053-gza05hsv | The( 1,3){beta}-D- glucan test as an aid to early diagnosis of invasive fungal infections following lung transplantation Diagnostic performance of the( 1? 3)-beta- D- glucan assay for invasive fungal disease Difficulties in using 1,3-{beta}-D- glucan as the screening test for the early diagnosis of invasive fungal infections in patients with haematological malignancies- high frequency of falsepositive results and their analysis Molecular and nonmolecular diagnostic methods for invasive fungal infections |
| cord-011053-gza05hsv | in hematopoietic stem cell transplant recipients? |
| cord-011053-gza05hsv | key to respiratory Ills? |
| cord-272357-fxe49zen | What is nanomedicine? |
| cord-008588-4eu9v5d3 | An important question not yet satisfactorily answered is: Which distances and torsion angles must be measured with what accuracy to specify a three- dimensional structure for RNA molecules? |
| cord-008588-4eu9v5d3 | Can unpaired nucleotides in all of the secondary structure loop types engage in tertiary pairing? |
| cord-008588-4eu9v5d3 | Do the surrounding base- pairs break to form an internal loop instead of a bulge? |
| cord-008588-4eu9v5d3 | Does a single base bulge that is looped out of the helix create a bend? |
| cord-008588-4eu9v5d3 | Finally, the effects of symmetrical and asymmetrical internal loops on the sugar- phosphate backbone must be explored: Do bends occur at internal loops? |
| cord-008588-4eu9v5d3 | For example, from the cloverleaf secondary structure of tRNA, how would the algorithm know that the junction conformation brings the D loop close to the T loop, but not to the anticodon loop? |
| cord-008588-4eu9v5d3 | How much does a bulge bend or kink the helix? |
| cord-008588-4eu9v5d3 | The main structural questions of interest are:( 1) Does one unpaired base intercalate into the helix, or is it extrahelical, with the base- pairs on either side stacked on each other? |
| cord-008588-4eu9v5d3 | What is the effect of very large bulge loops? |
| cord-269426-82g5eiyg | A replication- incompetent adenovirus vector with the preterminal protein gene deleted efficiently transduces mouse ears Nucleotide sequencing and generation of an infectious clone of adeno- associated virus 3 Live- attenuated HIV vaccines: how safe is safe enough? |
| cord-000436-k1hwh640 | An efficient approach to the production of vaccines against the malaria parasite Clinical application of surface- linked liposomal antigens Vaccine manufacturing: challenges and solutions Pathogen recognition and development of particulate vaccines: does size matter? |
| cord-000436-k1hwh640 | Antigen chemically coupled to the surface of liposomes are cross- presented to cd8? |
| cord-000436-k1hwh640 | Personalized vaccines: the emerging field of vaccinomics Strategies for the cell- free expression of membrane proteins Inability to immunize patients with metastatic melanoma using plasmid DNA encoding the gp100 melanoma- melanocyte antigen Correlates of antibody- mediated protection against hiv infection Cell- free translation reconstituted with purified components Cell- free synthetic biology: a bottom- up approach to discovery by design Botulism and vaccines for its prevention Femtoliter compartment in liposomes for in vitro selection of proteins Synthesis of functional proteins within liposomes Size effect on systemic and mucosal immune responses induced by oral administration of biodegradable microspheres Highly efficient antiviral cd8(?) |
| cord-000436-k1hwh640 | Preparation of PEG- liposomes and Ni 2? |
| cord-000436-k1hwh640 | The amount of encapsulated b- galactosidase as well as expressed b- galactosidase in bulk, inside the PEG- liposomes or bound onto Ni 2? |
| cord-000436-k1hwh640 | The expressed b- galactosidase has a 6-histidine residue which binds to Ni 2? |
| cord-000436-k1hwh640 | To prepare b- galactosidase- bound onto Ni 2? |
| cord-000436-k1hwh640 | hiv-1: Can we elicit them with vaccines and how much do we need? |
| cord-000436-k1hwh640 | i trial of a human papillomavirus DNA vaccine for hpv16? |
| cord-000436-k1hwh640 | ions of Ni 2?-NTA liposomes. |
| cord-022501-9wnmdvg5 | Is erysipelas- associated Tinea pedis a site of streptococcal colonisation? |
| cord-022501-9wnmdvg5 | Is it necessary to incubate the BacT/ Alert blood culture bottles more than 3 days? |
| cord-022501-9wnmdvg5 | Regarding MEPM, it was 85.9% for 500 mg gid? and |
| cord-006230-xta38e7j | 2´-deoxy- cAMP in human cell lines: Another second messenger? |
| cord-006230-xta38e7j | > Ser Extra- adrenal glucocorticoid synthesis in the intestinal epithelium: more than a drop in the ocean? |
| cord-006230-xta38e7j | Converging of the classical mitochondria- related pathway in Parkinson and nuclear DNA- repair signaling? |
| cord-006230-xta38e7j | Detoxification by conjugation of glutathione? |
| cord-006230-xta38e7j | Is formaldehyde a good example for a"genotoxic carcinogen"with a threshold mode of action? |
| cord-006230-xta38e7j | The transcriptome analyses of human cells showed that additionally to the 30.000 protein coding sequences the human DNA codes for much more( 450.000?) |
| cord-006230-xta38e7j | possible link between diabetes and cancer? |
| cord-017156-ximzvqbm | Do thermophiles have high( G+ C)% DNA? |
| cord-017156-ximzvqbm | In 1954 he set his students an essay"How does the Watson- Crick model account for synapsis?"[ II]. |
| cord-017156-ximzvqbm | Or did the ancestor not have isochores, which were therefore freshly acquired by the eukaryotic lineage after its divergence from the prokaryotic lineage( isochores- late)? |
| cord-017156-ximzvqbm | Since prokaryotes( e.g. bacteria) and eukaryotes( e.g. primates) are considered to have evolved from a common ancestor, does this mean that the ancestor had isochores that were subsequently lost by prokaryotes during or after their divergence from the eukaryote lineage( isochores- early)? |
| cord-017156-ximzvqbm | So how do nucleic acid s survive in thermophil es? |
| cord-017156-ximzvqbm | What role does the( G+C)%"accent"play in meiotic pairing? |
| cord-017156-ximzvqbm | ce ll, thu s releasin g four geno mes into an environment conducive to recombination? |
| cord-017156-ximzvqbm | rRNA genes) preserve their similarity to each other? |
| cord-267671-ys43n672 | Veterinary Microbiology and Microbial Disease Uteroovarian infection in aged B6C3F1 mice Breast cancer: should gastrointestinal bacteria be on our radar screen? |
| cord-274707-mxh38hwd | How will country- based mitigation measures influence the course of the COVID-19 epidemic? |
| cord-273993-rkqijcxn | How would the future of farm animals be with novel production traits, with resistance to transmissible diseases, or even with the eradication of pests that have harmed livestock throughout the history? |
| cord-273993-rkqijcxn | Is gene editing an acceptable alternative to castration in pigs? |
| cord-270082-byxd4o4m | Kinetochore Aid the Understanding of Kinetochore Function in More Complex Eukaryotes? |
| cord-279503-w4tn03w0 | Design of Gold Nanoparticle- Based Colorimetric Biosensing Assays Spontaneously formed sulfur adlayers on gold in electrolyte solutions: Adsorbed sulfur or gold sulfide? |
| cord-273347-eyxc4rt0 | An update Progress and problems with the use of viral vectors for gene therapy A tragic setback After Glybera's withdrawal, what's next for gene therapy? |
| cord-273347-eyxc4rt0 | Novel Strategies for Targeting Prostate Cancer Targeted nonviral gene therapy in prostate cancer Preparation of nanobubbles carrying androgen receptor siRNA and their inhibitory effects on androgen- independent prostate cancer when combined with ultrasonic irradiation Interleukin-27 gene delivery for modifying malignant interactions between prostate tumor and bone DNA/ Lipid complex incorporated with fibronectin to cell adhesion enhances transfection efficiency in prostate cancer cells and xenografts Autophagy modulators: mechanistic aspects and drug delivery systems Which one performs better for targeted lung cancer combination therapy: pre- or postbombesin- decorated nanostructured lipid carriers? |
| cord-278249-vvhq9vgp | Is a"cytokine storm"relevant to COVID-19? |
| cord-261028-sxux2ujo | combined with novel STING- targeting oligonucleotides results in regression of established tumors MHC class I endosomal and lysosomal trafficking coincides with exogenous antigen loading in dendritic cells Cross- presentation of viral and self antigens by skin- derived CD103+ dendritic cells Intestinal dendritic cells in the regulation of mucosal immunity Cross- priming for a secondary cytotoxic response to minor H antigens with H-2 congenic cells which do not cross- react in the cytotoxic assay Cross- priming Silencing of Irf7 pathways in breast cancer cells promotes bone metastasis through immune escape Apoptotic cell recognition: will the real phosphatidylserine receptor(s) please stand up? |
| cord-261028-sxux2ujo | radiotherapy- induced tumour immunogenicity Antigen- presentation properties of plasmacytoid dendritic cells cGAS is essential for the antitumor effect of immune checkpoint blockade Radiotherapy and immunotherapy: a beneficial liaison? |
| cord-261028-sxux2ujo | which signals induce tolerance or immunity Tumor associated regulatory dendritic cells Dendritic cells in the cancer microenvironment Do not let death do us part:'find- me'signals in communication between dying cells and the phagocytes The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting Dendritic cell development: a choose- your- own- adventure story Transcriptional priming of intrathymic precursors for dendritic cell development STING mediates neuronal innate immune response following Japanese encephalitis virus infection Antigen cross- presentation by dendritic cell subsets: one general or all sergeants? |
| cord-006068-w3if1hns | And does activation of TLRs contribute to the pathogenesis of systemic autoimmune diseases that are IFNα dependent to different extents? |
| cord-006068-w3if1hns | And, if so, to what extent would such therapeutics compromise the protective capacity of the immune system? |
| cord-006068-w3if1hns | And, if these ligands exist, what is their role in health and disease? |
| cord-006068-w3if1hns | Furthermore, mammalian DNA is a very weak immunogen in normal mice, so why are DNAand chromatin- specific antibodies so common in patients and mice with autoimmune disease? |
| cord-006068-w3if1hns | Given the many genetic and environmental factors that are likely to contribute to SLE in humans, will the contribution of TLR9( or TLR7) to disease activity in humans be equally variable? |
| cord-006068-w3if1hns | If endogenous DNA and RNA contribute to the development of systemic autoimmune disease, then are there endogenous ligands for other TLR- family members? |
| cord-006068-w3if1hns | So how does autoantibody specificity relate to disease mechanisms? |
| cord-006068-w3if1hns | Targeting Toll- like receptor signaling in plasmacytoid dendritic cells and autoreactive B cells as a therapy for lupus Lupus erythematosus treated with a combination of quinacrine, hydroxychloroquine, and chloroquine Antagonism of immunostimulatory CpG- oligodeoxynucleotides by quinacrine, chloroquine and structurally related compounds CpG- DNA- specific activation of antigen- presenting cells requires stress kinase activity and is preceded by non- specific endocytosis and endosomal maturation CpG motifs in bacterial DNA activate leukocytes through the pH- dependent generation of reactive oxygen species CpG motifs: the active ingredient in bacterial extracts? |
| cord-006068-w3if1hns | Will blockade of TLR7 and TLR9 prevent and/or ameliorate the clinical features of SLE and related diseases? |
| cord-006068-w3if1hns | effectively? |
| cord-005147-mvoq9vln | -how do we manage the extreme costs of these products, especially in light of the many unsolved issues with respect to effectiveness? |
| cord-005147-mvoq9vln | -what is the influence of antibody generation on clinical effectiveness? |
| cord-005147-mvoq9vln | -what is the natural history and"point of no return"for subgroups of patients within one LSD's? |
| cord-005147-mvoq9vln | > G;p.?) |
| cord-005147-mvoq9vln | And then: what is early? |
| cord-005147-mvoq9vln | Congenital myopathies and congenital muscular dystrophies: Will genetic testing replace muscle biopsy in the near future? |
| cord-005147-mvoq9vln | Disproportioned short stature and multiple anomalies in a patient with a homozygous PIK3C2A mutation-a new ciliopathy? |
| cord-005147-mvoq9vln | Inherited DNA repair mutations: are they modifiers of BRCA1 and BRCA2 penetrance and age at onset of hereditary breast and ovarian cancer? |
| cord-005147-mvoq9vln | Many unresolved questions exist at this stage, including the following:-what is the natural history and"point of no return"for the different LSD's? |
| cord-005147-mvoq9vln | What is the functional role of these ectopically expressed olfactory receptors? |
| cord-279084-bbae1qyx | cord-279084-bbae1qyx authors: Liu, Bin title: Free DNA, a reason for severe COVID-19 infection? |
| cord-278397-u33x4jaw | why so many receptors? |
| cord-022128-r8el8nqm | A unique intra- molecular fidelity- modulating mechanism identified in a viral RNA- dependent RNA polymerase Defective or effective? |
| cord-022128-r8el8nqm | Coxsackievirus B3 mutator strains are attenuated in vivo A single- nucleotide synonymous mutation in the gag gene controlling human immunodeficiency virus type 1 virion production Is sex necessary for the proliferation and transmission of Pneumocystis? |
| cord-022128-r8el8nqm | Linking RNA sequence, structure, and function on massively parallel highthroughput sequences Defective interfering influenza virus RNAs: time to reevaluate their clinical potential as broad- spectrum antivirals? |
| cord-022128-r8el8nqm | Pnemocystis genetic variability: cryptic biological species or clonal near- clades? |
| cord-022128-r8el8nqm | Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population Replication slippage involves DNA polymerase pausing and dissociation Genome instability: a conserved mechanism of ageing? |
| cord-022128-r8el8nqm | Ribavirin resistance in hepatitis C virus replicon- containing cell lines conferred by changes in the cell line or mutations in the replicon RNA Altering the intracellular environment increases the frequency of tandem repeat deletion during Moloney murine leukemia virus reverse transcription Transfection- mediated generation of functionally competent Tula hantavirus with recombinant S RNA segment Low- fidelity polymerases of alphaviruses recombine at higher rates to overproduce defective interfering particles Mechanisms of retroviral mutation Reproductive clonality in protozoan pathogens ─ truth or artefact? |
| cord-022128-r8el8nqm | reveals the dynamic nature of viral genome evolution Molecular Basis of Virus Evolution Functional and genetic plasticities of the poliovirus genome: quasi- infectious RNAs modified in the 5'-untranslated region yield a variety of pseudorevertants Nonreplicative homologous RNA recombination: promiscuous joining of RNA pieces? |
| cord-280549-bsnz24jx | a consequence of lesions to the chromatin? |
| cord-023698-wvk200j0 | A seroepidemiologic study of Chlamydia pneumoniae in Rhode Island Acute respiratory infection due to Chlamydia pneumoniae: current status of diagnostic methods Incidence of respiratory pathogens in persons hospitalized with pneumonia in two provinces in Thailand Etiology of community- acquired pneumonia: increased microbiological yield with new diagnostic methods Does respiratory infection due to Chlamydia pneumoniae still exist? |
| cord-023698-wvk200j0 | Conflicting results Is Chlamydia pneumoniae present in the cerebral spinal fluid of multiple sclerosis patients? |
| cord-023698-wvk200j0 | In- house nucleic acid amplification assays in research: how much quality control is needed before one can rely upon the results? |
| cord-023698-wvk200j0 | In- house nucleic acid amplification assays in research: how much quality control is needed before one can rely upon the results? |
| cord-023698-wvk200j0 | a meta- analysis Multiple sclerosis associated with Chlamydia pneumoniae infection of the CNS Infectious agents and multiple sclerosis: are Chlamydia pneumoniae and human herpes virus 6 involved? |
| cord-023698-wvk200j0 | fact or fiction Is Chlamydia pneumoniae found in spinal fluid samples from multiple sclerosis patients? |
| cord-023698-wvk200j0 | fact or fiction Is Chlamydia pneumoniae found in spinal fluid samples from multiple sclerosis patients? |
| cord-016808-gy8d8285 | , i.e., is there a single evolutionary tree or branch of viruses? |
| cord-016808-gy8d8285 | Do viruses form lineages across different domains of life? |
| cord-016808-gy8d8285 | Here a virus, there a virus, everywhere the same virus? |
| cord-016808-gy8d8285 | In other words, is there a place(s) for viruses on universal trees of life proposed for its three kingdoms, Archea, Eubacteria, and Eukarya? |
| cord-016808-gy8d8285 | Three RNA cells for ribosomal lineages and three DNA viruses to replicate their genomes: A hypothesis for the origin of cellular domain Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes Functional and genetic plasticities of the poliovirus genome: Quasi- infectious RNAs modified in the 5-untranslated region yield a variety of pseudorevertants Nonreplicative RNA recombination in poliovirus Nonreplicative homologous RNA recombination: Promiscuous joining of RNA pieces? |
| cord-016808-gy8d8285 | To what extent is the Muller's ratchet inevitable and irreversible? |
| cord-016808-gy8d8285 | What are relationships between viruses and cellular organisms? |
| cord-016808-gy8d8285 | What does then force them to evolve and to form new species and genera? |
| cord-016808-gy8d8285 | how does virus X remain virus X? |
| cord-279229-2226jnfl | What's in that band? |
| cord-277293-eo3bei9x | encodes a unique replication protein having both plasmid- and virus- like domains: clue to viral ancestry or result of virus/ plasmid recombination? |
| cord-281565-v8s2ski3 | Role in Escherichia coli global regulation Control of bacterial nitrate assimilation by stabilization of G- quadruplex DNA Case studies on potential G- quadruplexforming sequences from the bacterial orders Deinococcales and Thermales derived from a survey of published genomes The Presence and Localization of G- Quadruplex Forming Sequences in the Domain of Bacteria RNA G- Quadruplex Structures Mediate Gene Regulation in Bacteria Structural polymorphism of the four- repeat Oxytricha nova telomeric DNA sequences G- Quadruplexes in Pathogens: A Common Route to Virulence Control? |
| cord-282618-tjvjlyn9 | HEK293 cells were transfected with NTC7485-EGFP( same backbone as NTC8485, except for kanR instead of RNA- OUT) and NTC7485-EGFP- modified to contain: VA1( PKR+RNAI+ADAR+inhibitor); VA1-PKR3( PKRÀRNAI+ADAR?inhibitor), in which VA1 incorporated the L3 point mutation, 26( the designation'ADAR?'was used, as the effect of L3 on ADAR inhibition has not been established); or VA1-PKR5( PKRÀRNAI+ADAR+inhibitor) in which VA1 incorporated a 1 bp change( pm91) in the central domain. |
| cord-274080-884x48on | Molecular mechanism of divalentmetal- induced activation of NS3 helicase and insights into Zika virus inhibitor design HCV infection by cell- to- cell transmission: choice or necessity? |
| cord-274080-884x48on | Novel ESCRT functions in cell biology: spiraling out of control? |
| cord-272943-q09i8fqu | Do quinolones bind to DNA? |
| cord-272943-q09i8fqu | The anti- HIV-1 activity of chloroquine Anti- HIV effects of chloroquine: mechanisms of inhibition and spectrum of activity Effects of chloroquine on viral infections: an old drug against today's diseases? |
| cord-272943-q09i8fqu | key: cord-272943-q09i8fqu authors: Dalhoff, A. title: Antiviral, antifungal, and antiparasitic activities of fluoroquinolones optimized for treatment of bacterial infections: a puzzling paradox or a logical consequence of their mode of action? |
| cord-279267-iyobsuvz | Rational vector design and multi- pathway modulation of HEK 293E cells yield recombinant antibody titers exceeding 1 g/ l by transient transfection under serum- free conditions Glycoproteins from insect cells: sialylated or not? |
| cord-279267-iyobsuvz | the CAP- T(R) cell system Serum- free transient protein production system based on adenoviral vector and PER.C6 technology: high yield and preserved bioactivity A highly conserved neutralizing epitope on group 2 influenza A viruses Highly conserved protective epitopes on influenza B viruses Versatile expression system for rapid and stable production of recombinant proteins Use of orbital shaken disposable bioreactors for mammalian cell cultures from the milliliter- scale to the 1000-liter scale Disposable bioreactors: the current state- of- the- art and recommended applications in biotechnology Innovative, non- stirred bioreactors in scales from milliliters up to 1000 liters for suspension cultures of cells using disposable bags and containers- a Swiss contribution Disposable bioreactor for cell culture using wave- induced agitation Optimisation of protein expression and establishment of the wave bioreactor for baculovirus/ insect cell culture Serum- free suspension large- scale transient transfection of CHO cells in WAVE bioreactors High- level protein expression in scalable CHO transient transfection Development of a shaking bioreactor system for animal cell cultures Scalable transient gene expression in Chinese hamster ovary cells in instrumented and non- instrumented cultivation systems Efficient oxygen transfer by surface aeration in shaken cylindrical containers for mammalian cell cultivation at volumetric scales up to 1000L Advances in shaking technologies TubeSpin bioreactor 50 for the high- density cultivation of Sf-9 insect cells in suspension Small- scale bioreactor system for process development and optimization Multiplexed expression and screening for recombinant protein production in mammalian cells Determination of a scale- up factor from mixing time studies in orbitally shaken bioreactors Efficient and reproducible mammalian cell bioprocesses without probes and controllers? |
| cord-253466-7gpije5d | , 2004) induces vesicles and dispersal of the Golgi apparatus, which begs the questions, does this mutant use a different process for forming the replication complex, or do the mutations in 3A allow the proteins to compete with BFA for GBF1 recruitment? |
| cord-253466-7gpije5d | African swine fever virus is wrapped by the endoplasmic reticulum Cellular COPII proteins are involved in production of the vesicles that form the poliovirus replication complex Vaccinia virus membrane proteins p8 and p16 are cotranslationally inserted into the rough endoplasmic reticulum and retained in the intermediate compartment Daxx: Death or survival protein? |
| cord-253466-7gpije5d | Biogenesis from scratch? |
| cord-253466-7gpije5d | Hijacking components of the secretory pathway for replication of poliovirus RNA Does common architecture reveal a viral lineage spanning all three domains of life? |
| cord-253466-7gpije5d | Viral interactions with the cytoskeleton of mammalian cells Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex Assembly of vaccinia virus revisited: De novo membrane synthesis or acquisition from the host? |
| cord-258014-lzzi4rnz | ( 2) Can differences in microbiome metabolic capabilities explain metabolite variation? |
| cord-258014-lzzi4rnz | It answers questions such as:( 1) Do the metabolites in a given dataset appear to vary depending on microbiome composition? |
| cord-258014-lzzi4rnz | Which ones? |
| cord-258014-lzzi4rnz | Which taxa, genes, and reactions appear to be playing a role in metabolite differences? |
| cord-262870-r3w44mg0 | Before evaluating the delivery capabilities of your vector, the first question you may ask is:''The vector which I use, can it be responsible for a toxic phenomenon?'' |
| cord-262870-r3w44mg0 | This approach obliges you to use microscopy techniques: fluorescence microscopy will just allow you to verify if the transfection succeeded( i.e. were cells transfected?); the confocal microscopy will allow you to see exactly in which cellular compartment is located the labeling( i.e. cytoplasmic, nuclear...); and finally you can even use flow cytometry which will allow you to determine, more rapidly than a manual counting, your efficiency of transfection( i.e. how many cells were transfected?)... |
| cord-262870-r3w44mg0 | This approach obliges you to use microscopy techniques: fluorescence microscopy will just allow you to verify if the transfection succeeded( i.e. were cells transfected?); the confocal microscopy will allow you to see exactly in which cellular compartment is located the labeling( i.e. cytoplasmic, nuclear...); and finally you can even use flow cytometry which will allow you to determine, more rapidly than a manual counting, your efficiency of transfection( i.e. how many cells were transfected?)... |
| cord-286684-2xmd3jfo | through TaqMan polymerase chain reaction targeting the LipL32 gene Causes of equine abortion, stillbirth and neonatal death in central Italy Investigation of coxiella burnetii occurrence in dairy sheep flocks by molecular analysis in Umbrian area: a pilot study Serological surveillance of Leptospirosis in Italy: two- year national data Survey of seroprevalence of Q fever in dogs in the southeast of France Serological survey of leptospiral infection in kennelled dogs in Italy Seroprevalence of Coxiella burnetii infections among cats in different living environments Serologic and urinary PCR survey of leptospirosis in healthy cats and in cats with kidney disease Canine and feline abortion diagnostics Funisitis associated with leptospiral abortion in an equine placenta Q fever: a zoonosis Canine leptospirosisÀdo we have a problem? |
| cord-285982-1a5u7uux | recent advances in the cytotoxic T- Iymphocyte platform"spotty business DNA vaccines: ready for prime time? |
| cord-286719-1xjmlwqr | Cytomegalovirus: pathogen, paradigm, and puzzle International consensus guidelines on the management of cytomegalovirus in solid organ transplantation Neonatal cytomegalovirus blood load and risk of sequelae in symptomatic and asymptomatic congenitally infected newborns Is HCMV a tumor promoter? |
| cord-023209-un2ysc2v | And, is Abeta modifi ed by 1( 2) able to aggregate at low concentrations on a biologically relevant time scale? |
| cord-023209-un2ysc2v | Because these compounds were rationally designed by using the co- crystallized structure of VEGF with the immunoglobulin like fragment 2 of VEGFR-1, we raise the following question: do these antagonists really target the immunoglobulin like domain 2 of VEGFR-1? |
| cord-023209-un2ysc2v | C more or less resistant to denaturation conditions? |
| cord-023209-un2ysc2v | Conformational preferences of investigated systems were obtained on base of ROESY and NOESY experiments and calculations by use of X- PLOR and quantum chemical calculation Is concentration overload or volume overload the best strategy for synthetic peptide purifi cation? |
| cord-023209-un2ysc2v | Peptido2.rotaxanes: can a tetramide macrocycle travel to a station by wrapping up around a helical peptide thread? |
| cord-023209-un2ysc2v | lower the CC of Abeta aggregation into the PC range? |
| cord-288444-0vv4neq6 | A thin- layer model for viscoelastic, stress- relaxation testing of cells using atomic force microscopy: do cell properties reflect metastatic potential? |
| cord-277665-ac8txr3h | In vitro studies of new prosthesis coatings Synthesis and antimicrobial activity of new adamantane derivatives III Quantum dots and other nanoparticles: What can they offer to drug discovery? |
| cord-291749-revhbd0q | What do we know about ribosomal RNA methylation in Escherichia coli? |
| cord-277318-cwuls6xs | How then do translocating ribosomes unwind the downstream mRNA structure they encounter? |
| cord-277318-cwuls6xs | However, can such a condensed 1D projection capture the relevant thermodynamics and kinetics of the systems studied? |
| cord-277318-cwuls6xs | In other words, what makes a"good"reaction coordinate? |
| cord-288879-rj03dsib | This leads to the question: what possible functions could they serve for the virus itself or interaction with host cells? |
| cord-292794-okh6i4l1 | Five micrometer sections were cut and stained with hematoxylin and eosin( H&E), and reviewed for histopathologic changes. 2006BAD06A04/03), and the Chinese Research Fund for Non- profit Research Institutions Dual infections of feeder pigs with porcine reproductive and respiratory syndrome virus followed by porcine respiratory coronavirus or swine influenza virus: a clinical and virological study Molecular basis for the generation in pigs of influenza A viruses with pandemic potential Emergence and pandemic potential of swine- origin H1N1 influenza virus Emergence of a novel swine- origin influenza A( H1N1) virus in humans Immunization of pigs with a particle- mediated DNA vaccine to influenza A virus protects against challenge with homologous virus Isolation and genetic analysis of human origin H1N1 and H3N2 influenza viruses from pigs in China Emergence of avian H1N1 influenza viruses in pigs in China Cocirculation of avian H9N2 and contemporary"human"H3N2 influenza A viruses in pigs in southeastern China: potential for genetic reassortment? |
| cord-006229-7yoilsho | But what would happen if the HFD was switched to normal pellet diet in these diabetic rats? |
| cord-006229-7yoilsho | Core or coating material? |
| cord-006229-7yoilsho | Increased GABA release in human neocortex at high intracellular sodium and low extracellular calcium-an anti- seizure mechanism?] |
| cord-006229-7yoilsho | Occasionally there are specific questions occurring on the ruminant xenobiotic metabolism: 1) are the observed metabolites ruminant specific and formed directly in the rumen? 2) are ruminants able to cleave plant specific metabolites like glycosides to the respective aglycon? |
| cord-006229-7yoilsho | Occasionally there are specific questions occurring on the ruminant xenobiotic metabolism: 1) are the observed metabolites ruminant specific and formed directly in the rumen? 2) are ruminants able to cleave plant specific metabolites like glycosides to the respective aglycon? |
| cord-006229-7yoilsho | The data point to a role of Rac1-regulated filamentous( nuclear?) |
| cord-006229-7yoilsho | The γH2AX Assay for Genotoxic and Nongenotoxic Agents: Comparison of H2AX Phosphorylation with Cell Death Response Perturbation of mitosis through inhibition of histone acetyltransferases: the key to ochratoxin a toxicity and carcinogenicity? |
| cord-006229-7yoilsho | Vitamin D metabolism-Involved in triazole fungicide toxicity? |
| cord-006229-7yoilsho | What dictates the uptake and translocation of nanoparticles in vitro? |
| cord-006229-7yoilsho | What would happen without this exception? |
| cord-254527-zddwajzg | An improved manufacturing process for Xyntha/ ReFacto AF Evaluation of the virus clearance capacity and robustness of the manufacturing process for the recombinant factor VIII protein, turoctocog alfa Alternative affinity ligands for immunoglobulins Protein A chromatography for antibody purification Trends in upstream and downstream process development for antibody manufacturing The role of more than 40 years of improvement in protein A chromatography in the growth of the therapeutic antibody industry Quality by design approach for viral clearance by protein A chromatography Identification of protein A media performance attributes that can be monitored as surrogates for retrovirus clearance during extended reuse Robustness of virus removal by protein A chromatography is independent of media lifetime Clearance of the rodent retrovirus, XMuLV, by protein A chromatography Virus elimination during the purification of monoclonal antibodies by column chromatography and additional steps Many factor VIII products available in the treatment of hemophilia A: an embarrassment of riches? |
| cord-254527-zddwajzg | Pathogen inactivation and removal methods for plasma- derived clotting factor concentrates A review of the invasive mosquitoes in Europe: ecology, public health risks, and control options Viral vaccines and their manufacturing cell substrates: new trends and designs in modern vaccinology Vaccination against dengue: challenges and current developments Ebola virus vaccines: where do we stand? |
| cord-254527-zddwajzg | Production of recombinant coagulation factors: Are humans the best host cells? |
| cord-254527-zddwajzg | Recent developments in chromatographic purification of biopharmaceuticals Evolving trends in mAb production processes Affinity chromatography for vaccines manufacturing: finally ready for prime time? |
| cord-254527-zddwajzg | What perspectives for PS- based chromatography materials in this background of technological development? |
| cord-291960-1is0rv6c | Consensus Group ECIL guidelines for the diagnosis of Pneumocystis jirovecii pneumonia in patients with haematological malignancies and stem cell transplant recipients Clinical manifestations of graft- versus- hostmdisease in human recipients of marrow from HL- A- matched sibling donors Are we there yet? |
| cord-271635-tydlyc1q | Can methanolic extract of Nigella sativa seed affect glyco- regulatory enzymes in experimental hepatocellular carcinoma? |
| cord-271635-tydlyc1q | Resveratrol down- regulates Myosin light chain kinase, induces apoptosis and inhibits diethylnitrosamine- induced liver tumorigenesis in rats Inflammation and cancer: back to Virchow? |
| cord-271635-tydlyc1q | What do we know so far? |
| cord-271635-tydlyc1q | a potential biomarker of mitochondrial dysfunction? |
| cord-283880-lrrkuist | A novel rhabdovirus associated with acute hemorrhagic fever in central Africa Viral evolution: beyond drift and shift Rapid metagenomic identification of viral pathogens in clinical samples by real- time nanopore sequencing analysis Depletion of Abundant Sequences by Hybridization( DASH): using Cas9 to remove unwanted high- abundance species in sequencing libraries and molecular counting applications Viral metagenomics: are we missing the giants? |
| cord-283880-lrrkuist | a paradigm shift in evolutionary biology? |
| cord-014462-11ggaqf1 | Both ATP and GTP were utilized as phosporyl donors and Mn 2? |
| cord-014462-11ggaqf1 | Cut off was calculated as Mean negative control? |
| cord-014462-11ggaqf1 | FMDV P1- 3CD''O''vaccine gene constructs in pCDNA3.1? entrapped by the nanoparticles was prepared by using different molarity of calcium chloride and disodium hydrogen orthophosphate. |
| cord-014462-11ggaqf1 | Helicase activity of NSs was absolutely dependent on ATP and Mg 2? |
| cord-014462-11ggaqf1 | How do Indian journals perform in Maintaining quality? |
| cord-014462-11ggaqf1 | How do motivate the scientists to improve their scientific output? |
| cord-014462-11ggaqf1 | How to motivate the scientists to improve their scientific output? |
| cord-014462-11ggaqf1 | In this regard, rNSs is a unique enzyme which does not have the canonical helicase motifs but can catalyze dsDNA/ dsRNA unwinding in an ATP and Mg 2? |
| cord-014462-11ggaqf1 | Should we compare the growth of Indian science with other developed countries? |
| cord-014462-11ggaqf1 | What ails Indian Science? |
| cord-014462-11ggaqf1 | What criteria should be adopted to judge the quality and standard of scientific research? |
| cord-288445-6i5fbdcu | Can graphene be used as a substrate for Raman enhancement? |
| cord-282251-r4on3lpr | Directing evolution: the next revolution in drug discovery? |
| cord-282251-r4on3lpr | How were new medicines discovered? |
| cord-008777-i2reanan | ( 2) Is adhesion between leukocytes and endothelial cells affected by VCAM-1-specific siRNA? |
| cord-008777-i2reanan | (??). |
| cord-008777-i2reanan | (??). |
| cord-008777-i2reanan | A recent EcoNexus report underlined the potential for the process of plant transformation to result in genetic damage to the transformed plant( Genome Scrambling- Myth or Reality? |
| cord-008777-i2reanan | Arabidopsis thaliana- Distinct function in gene transcription dynamics? |
| cord-008777-i2reanan | Are they being adsorbed to the core cellulose chain or partly solubilized to a hydrolysis broth?" |
| cord-008777-i2reanan | Extending life by alternative respiration? |
| cord-008777-i2reanan | For example, one of the often asked questions is:"What is happening with shorter cellooligosacharides( DP 7 and up) laying on the surface of cellulose chain? |
| cord-008777-i2reanan | In order to further substantiate the potential use of siRNA for therapeutic purposes, we have set out to investigate two things:( 1) Does VCAM-1-specific siRNA affect the amount of VCAM-1 on the surface of HUVEC? |
| cord-008777-i2reanan | Is this realistic? |
| cord-008777-i2reanan | Two days of open discussions were organized in the context of the Austrian Genome Research Program GEN- AU( 3): topics were"Gene Diagnosis"( 2002) and"Genome Research- what is in it for me?"( 2004). |
| cord-008777-i2reanan | Will we switch from a petrochemical industry to a biobased chemistry within the next years? |
| cord-032183-yqqqe325 | An integration of deep viral suppression with sequential immune modulation( cocktail therapy) to restore antiviral capacity: the future of chronic hepatitis B? |
| cord-032183-yqqqe325 | Dissecting the divergent effects of interferon- alpha on immune cells: time to rethink combination therapy in chronic hepatitis B? |
| cord-032183-yqqqe325 | Does antiviral therapy reduce complications of cirrhosis? |
| cord-032183-yqqqe325 | Entecavir treatment prevents disease progression in hepatitis B virus- related acute- on- chronic liver failure: establishment of a novel logistical regression model Management of severe acute to fulminant hepatitis B: to treat or not to treat or when to treat? |
| cord-032183-yqqqe325 | HBV cure- can we pin our hopes on immunotherapy? |
| cord-032183-yqqqe325 | What MELD score mandates use of entecavir for ACLF- HBV HBeAg- negative patients? |
| cord-032183-yqqqe325 | hepatitis B immunoglobulin necessary in prophylaxis of hepatitis B recurrence after liver transplantation? |
| cord-032183-yqqqe325 | the effect of preventive lamivudine on hepatitis B reactivation during chemotherapy Management of the HBV reactivation in isolated HBcAb positive patients affected with Non Hodgkin Lymphoma Hepatitis B virus reactivation associated with anti- neoplastic therapy Thyroid abnormalities in chronic viral hepatitis and their relationship to interferon alfa therapy Can pegylated interferon alpha 2a cause development of thyroid disorders in patients with chronic hepatitis B? |
| cord-285262-690kpupt | Natural killer and lymphokine- activated killer cells require granzyme B for the rapid induction of apoptosis in susceptible target cells A cytomegalovirus- encoded inhibitor of apoptosis that suppresses caspase-8 activation Pseudomonas aeruginosa quorumsensing metabolite induces host immune cell death through cell surface lipid domain dissolution Murine cytomegalovirus IE3-dependent transcription is required for DAI/ ZBP1-mediated necroptosis Is receptor- interacting protein kinase 3 a viable therapeutic target for Mycobacterium tuberculosis infection? |
| cord-254646-psolkrom | Are vitamin D guidelines a"one size fits all"or should they be more nuanced to respect the range of human pigmentation and culture? |
| cord-254646-psolkrom | But what about other conditions for which vitamin D may have some modifying actions? |
| cord-254646-psolkrom | Can the average person finely calibrate 0.2 minimal erythema dose, the point at which vitamin D synthesis occurs without perceptible DNA damage? |
| cord-254646-psolkrom | Is there such a thing as"sensible"sun exposure? |
| cord-254646-psolkrom | World Health Organization Sunlight and dietary contributions to the seasonal vitamin D status of cohorts of healthy postmenopausal women living at northerly latitudes: a major cause for concern? |
| cord-254646-psolkrom | systematic review and meta- analysis of individual participant data Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths COVID-19 and vitamin D- is there a link and an opportunity for intervention? |
| cord-280429-4fota9rl | A new DNA binding protein highly conserved in diverse crenarchaeal viruses Structure of A197 from Sulfolobus turreted icosahedral virus: A crenarchaeal viral glycosyltransferase exhibiting the GT- A fold The bacterial conjugation protein TrwB resembles ring helicases and F1-ATPase Structure of the VirB4 ATPase, alone and bound to the core complex of a type IV secretion system Polintons: A hotbed of eukaryotic virus, transposon and plasmid evolution Virophages or satellite viruses? |
| cord-280429-4fota9rl | Archaeal viruses: Living fossils of the ancient virosphere? |
| cord-280429-4fota9rl | What does structure tell us about virus evolution? |
| cord-022888-dnsdg04n | /CRTAM on gd T cells? |
| cord-022888-dnsdg04n | As the results show, could there not be a direct relationship between the HLA system and the development of SA or TBC, or in contrast, was the first patient missdiagnosed of TBC being a good prognosis SA? |
| cord-022888-dnsdg04n | Could Carabin play a role of negative regulator of B cell function? |
| cord-022888-dnsdg04n | How is the IGSF4-CRTAM axis regulated in T cells? |
| cord-022888-dnsdg04n | a one- year prospective birth cohort study PC09/16 TO WHAT EXTENT T- SPOT.TB COULD BE USED IN THE DIAGNOSIS OF TUBERCULOSIS IN CHILDREN EXPOSED TO TB INFECTION? |
| cord-284690-ogu1gmcb | Antimicrobial and host- defense peptides as new anti- infective therapeutic strategies Antimicrobial peptides( AMPs) as drug candidates: a patent review Quality specifications for peptide drugs: a regulatorypharmaceutical approach Antimicrobial peptides stage a comeback Future directions for peptide therapeutics development Rational design of engineered cationic antimicrobial peptides consisting exclusively of arginine and tryptophan, and their activity against multidrug- resistant pathogens Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? |
| cord-284690-ogu1gmcb | Can innate immunity be enhanced to treat microbial infections? |
| cord-023724-5at0rhqk | ( Long- term) pathogenic consequences? |
| cord-023724-5at0rhqk | A high proportion of the human population has already been vaccinated- lifelong protection may result in poor response to recombinant vaccines(?). |
| cord-023724-5at0rhqk | Difficult to grow to high titer and purify for direct administration( patient cells must be cultured in vitro); can not infect nondividing cells- most somatic cells( except lentiviruses?); insertional mutagenesis/ activation of cellular oncogenes. |
| cord-023724-5at0rhqk | How do CRISPRs work? |
| cord-023724-5at0rhqk | How do plant viruses induce disease? |
| cord-023724-5at0rhqk | How do viruses avoid inhibition by endogenous cellular microRNAs? |
| cord-023724-5at0rhqk | Integrate into cell genome, giving long- lasting( lifelong?) |
| cord-023724-5at0rhqk | So how do bacteria survive against this constant onslaught? |
| cord-023724-5at0rhqk | So who( apart from bacteria) cares about CRISPRs? |
| cord-290617-45be6gxe | G cytidine deaminase association with coronavirus nucleocapsid protein Evidence for host- dependent RNA editing in the transcriptome of SARS- CoV-2 Human coronaviruses: what do they cause? |
| cord-290617-45be6gxe | Why is CpG suppressed in the genomes of virtually all small eukaryotic viruses but not in those of large eukaryotic viruses? |
| cord-298697-v1qdizwx | Front Diversity and distribution of intertidal marine species in Singapore From marine park to future genomic observatory? |
| cord-284582-xwedgllw | But does this cfDNA have a physiological role? |
| cord-284582-xwedgllw | This raises the following question: What is the fundamental role of cfDNA in healthy organisms? |
| cord-291349-tq2n4mx3 | ( b) If so, how? |
| cord-291349-tq2n4mx3 | Transgene expression in the provirus is driven by the viral 5? |
| cord-285077-okwck5sv | Otolaryngol Head Neck Surg Comparison of in vitro inactivation of SARS CoV-2 with hydrogen peroxide and povidone- iodine oral antiseptic rinses Is povidone iodine mouthwash effective against SARS- CoV-2? |
| cord-285077-okwck5sv | Surgical smoke and ultrafine particles Is surgical smoke harmful to theater staff? |
| cord-285077-okwck5sv | a systematic review Use of powered air- purifying respirator( PAPR) by healthcare workers for preventing highly infectious viral diseases- a systematic review of evidence How well do N95 respirators protect healthcare providers against aerosolized influenza virus? |
| cord-015348-qt0worsl | ( 2) ABMR but no C4d? |
| cord-015348-qt0worsl | ( 3) Are"atypical"staining patterns of diagnostic relevance? |
| cord-015348-qt0worsl | ** Germany How to scale image information in virtual slides? |
| cord-015348-qt0worsl | Expression of MMP-2 and PTEN in laryngeal squamous cell carcinoma- biological predictors? |
| cord-015348-qt0worsl | How to separate follicular adenoma from follicular carcinoma and follicular variant PTC? |
| cord-015348-qt0worsl | In my talk, I will address the following issues:( 1) C4d deposits but no ABMR? |
| cord-015348-qt0worsl | Is this entirely new? |
| cord-015348-qt0worsl | The association between neoplasia of the endometrium and others benign genital lesions: independent or similar mechanism? |
| cord-015348-qt0worsl | The first question to be considered when handling a problematic pleural biopsy is: Is the biopsy material adequate and representative as can be judged from clinical, imaging and thoracoscopic findings? |
| cord-015348-qt0worsl | Updates of TNM classification: for the better or worse? |
| cord-015348-qt0worsl | antigens reliable markers of stem cells in squamous cell carcinoma of vulva? |
| cord-302486-z36hcvrx | Negative staining method for high resolution electron microscopy of viruses Detection of prions in blood Multiplex realtime quantitative RT- PCR assay for hepatitis B virus, hepatitis C virus, and human immunodeficiency virus type 1 DNA microarrays of the complex human cytomegalovirus genome: profiling kinetic class with drug sensitivity of viral gene expression A role for arrays in clinical virology: fact or fiction? |
| cord-293421-0ksn0fc7 | I? |
| cord-293421-0ksn0fc7 | spir{}chete Borrelia blt~:&~dorfi, Ji itsing th{: i}{}lymerase clmi, t reaction P{}h'nlerase chain reaction: a rev{}l- uti{}n ill diagn{}sis{'} f ocular lcishmaniosis? |
| cord-271504-t3y1w9ef | , its homologue ACE2 and neprilysin in angiotensin peptide metabolism COVID-19 and angiotensinconverting enzyme inhibitors and angiotensin receptor Blockers Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-271504-t3y1w9ef | : lessons from severe acute respiratory syndrome and Middle East respiratory syndrome Radiology of severe acute respiratory syndrome( SARS): the emerging pathologic- radiologic correlates of an emerging disease Middle East respiratory syndrome coronavirus: what does a radiologist need to know? |
| cord-271504-t3y1w9ef | A human monoclonal antibody blocking SARS- CoV-2 infection Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes IgM in microbial infections: taken for granted? |
| cord-271504-t3y1w9ef | The SARS- coronavirus papain- like protease: structure, function and inhibition by designed antiviral compounds Crystal Structures of the Main Peptidase from the SARS Coronavirus Inhibited by a Substrate- like Aza- peptide Epoxide Simultaneous treatment of human bronchial epithelial cells with serine and cysteine protease inhibitors prevents severe acute respiratory syndrome coronavirus entry Protease inhibitors targeting coronavirus and filovirus entry Efficacy of camostat mesilate compared with famotidine for treatment of functional dyspepsia: is camostat mesilate effective? |
| cord-271504-t3y1w9ef | The broad- spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen Signatures of nucleotide analog incorporation by an RNA- dependent rna polymerase revealed using high- throughput magnetic tweezers Ribavirin in the treatment of SARS: a new trick for an old drug? |
| cord-271504-t3y1w9ef | What happens to people's lungs when they get coronavirus? |
| cord-304375-l5gvpat3 | alkanediamines with potential against chloroquine- resistant malaria Chloroquine and hydroxychloroquine as inhibitors of human immunodeficiency virus( HIV-1) activity Effects of chloroquine on viral infections: an old drug against today's diseases? |
| cord-303319-v3iyur78 | The interferon response to intracellular DNA: why so many receptors? |
| cord-283461-xcyvisqu | TMEM173 Drives lethal coagulation in sepsis Clinical and immunological features of severe and moderate coronavirus disease Inflammasome activation triggers blood clotting and host death through pyroptosis Effect of antiplatelet agents clopidogrel, aspirin, and cilostazol on circulating tissue factor procoagulant activity in patients with peripheral arterial disease Potential therapeutic effects of dipyridamole in the severely ill patients with COVID-19 Classical and pleiotropic actions of dipyridamole: not enough light to illuminate the dark tunnel? |
| cord-283461-xcyvisqu | a potential role in the risk to develop heart vascular abnormalities? |
| cord-283461-xcyvisqu | authors: Berthelot, Jean- Marie; Drouet, Ludovic; Lioté, Frédéric title: Kawasaki- like diseases and thrombotic coagulopathy in COVID-19: delayed over- activation of the STING pathway? |
| cord-304283-nv4ret1f | Matrilysin( matrix metalloproteinase-7): a new promising drug target in cancer and inflammation? |
| cord-031907-ilhr3iu5 | Extracellular Vesicle- based liquid biopsy in Acute Myeloid Leukaemia: a reliable source of residual disease biomarkers? |
| cord-298183-cisrvghj | Are there other microbial pathogens that are significant causes of human disease and await discovery? |
| cord-298183-cisrvghj | If microbes are the cause of some idiopathic diseases, why have we not discovered them yet? |
| cord-302880-sizk6mk6 | The role of endemic plants in Mauritian traditional medicine- Potential therapeutic benefits or placebo effect? |
| cord-298051-ej8qxkce | How is DNA amplification monitored in real time during qPCR? |
| cord-298051-ej8qxkce | What about viruses with an RNA genome? |
| cord-304188-1nm1tbig | Papers of particular interest, published within the annual period of review, have been highlighted as: Immune stimulation systemic inflammation Safety fewer side effects? |
| cord-296886-0bma2749 | ( IHN) virus DNA vaccine in Chinook Oncorhynchus tshawytscha and sockeye O. nerka salmon DNA and RNA- based vaccines: Principles, progress and prospects DNA vaccines- A modern gimmick or a boon to vaccinology? |
| cord-296886-0bma2749 | Progress and challenges Synthetic DNA vaccine strategies against persistent viral infections DNA vaccines: Ready for prime time? |
| cord-306780-9xelf8oh | possible links with the international trade in small carnivores What has molecular epidemiology ever done for wildlife disease research? |
| cord-304685-s0bfhwtn | Virol Quantitative studies of amino acid and growth factor requirements of transformed and nontransformed cells in high concentrations of serum or lymph CTL: virus control ceils first and cytolytic cells second? |
| cord-301128-woe6knpv | A fingerprint of DNA/ RNA demixing? |
| cord-301128-woe6knpv | The question that remains to be answered is consequently: What additional constraint must the DNA- bridging protein exert on its binding sites in order to preserve not only the difference in torsional stress between the two moieties of the DNA chain, but rather the precise initial torsional stress in each moiety? |
| cord-280605-2i4gk7et | A SYSDIET Sub- Study Eicosapentaenoic acid and prevention of thrombosis and atherosclerosis? |
| cord-280605-2i4gk7et | Do You Remember Mitochondria? |
| cord-280605-2i4gk7et | What is a healthy Nordic diet? |
| cord-280605-2i4gk7et | attenuates atherosclerotic plaque formation in diet and inflammation- induced atherogenesis Human CNS immune senescence and neurodegeneration Microglial senescence: does the brain's immune system have an expiration date? |
| cord-307768-xx46w6dc | What is next generation sequencing? |
| cord-316534-ep7ezoko | The failed HIV Merck vaccine study: a step back or a launching point for future vaccine development? |
| cord-274128-kgtr77e7 | A revolutionary tool for mechanobiology? |
| cord-274128-kgtr77e7 | How do these techniques work? |
| cord-274128-kgtr77e7 | Microfluidic Devices for Drug Assays Presegmentation Procedure Generates Smooth- Sided Microfluidic Devices: Unlocking Multiangle Imaging for Everyone? |
| cord-274128-kgtr77e7 | Simple approaches to minimally- instrumented, microfluidic- based point- of- care Nucleic Acid Amplification Tests Malaria and the"last"parasite: How can technology help? |
| cord-274128-kgtr77e7 | What can we detect? 2. |
| cord-274128-kgtr77e7 | Which detection technologies are used in which setting? 3. |
| cord-297203-f3f31h4r | Replication- deficient ebolavirus as a vaccine candidate Single- dose immunization with virus replicon particles confers rapid robust protection against Rift Valley fever virus challenge Virus- like particles in vaccine development Virus- like particles as particulate vaccines Formulation and stabilization of recombinant protein based virus- like particle vaccines Vaccines for the 21st century DNA vaccines: recent developments and future possibilities DNA vaccines-back in the saddle again? |
| cord-297203-f3f31h4r | The yellow fever 17D virus as a platform for new live attenuated vaccines From research to hase III: preclinical, industrial and clinical development of the Sanofi Pasteur tetravalent dengue vaccine Creation of a recombinant Rift Valley fever virus with a two- segmented genome IRES dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells IRES- based Venezuelan equine encephalitis vaccine candidate elicits protective immunity in mice Modulation of poliovirus replicative fitness in HeLa cells by deoptimization of synonymous codon usage in the capsid region Development of live attenuated arenavirus vaccines based on codon deoptimization Adenoviruses as vaccine vectors Pre- existing immunity against Ad vectors: humoral, cellular, and innate response, what's important? |
| cord-285505-8norumv6 | : What opportunity exists for a better nucleoside/ nucleotide to treat hepatitis C? |
| cord-285505-8norumv6 | In contrast, there was far less protection in clinical trials-why? |
| cord-285505-8norumv6 | Is it possible that raltegravir is inducing a single round of HIV replication, to give an increase in HIV circles? |
| cord-285505-8norumv6 | What is the role of T- cell responses? |
| cord-252871-qfrpuy3t | : do we need a fourth domain of life to explain the origin of eukaryotes? |
| cord-252871-qfrpuy3t | Can protein structure- based methods improve the evolutionary studies of viruses? |
| cord-252871-qfrpuy3t | Do well defined boundaries exist between cellular and viral lineages? |
| cord-252871-qfrpuy3t | How are RNA and DNA viruses evolutionarily related? |
| cord-252871-qfrpuy3t | How do we explain the origin and abundance of virus- specific genes in viral genomes? |
| cord-252871-qfrpuy3t | How to visualize and illustrate viruses( virus factories) if virions can not and should not be used to describe viruses? |
| cord-252871-qfrpuy3t | The path from the RNA world Three RNA cells for ribosomal lineages and three DNA viruses to replicate their genomes: A hypothesis for the origin of cellular domain Mimivirus: The emerging paradox of quasi- autonomous viruses Phylogenetic tree building in the genomic age Benefits of using molecular structure and abundance in phylogenomic analysis Can sequence phylogenies safely infer the origin of the global virome? |
| cord-252871-qfrpuy3t | Viral eukaryogenesis: was the ancestor of the nucleus a complex DNA virus? |
| cord-278081-tk7vn1v1 | And what is the distribution and composition of RNAs and proteins in nucleolar fragments compared to intact nucleoli? |
| cord-278081-tk7vn1v1 | And, perhaps most important, what does this new hypothesis present as far as therapeutic targets? |
| cord-278081-tk7vn1v1 | For example, what is the effect of acetylated polyamines if they were to compete with spermidine and spermine in the nucleolar folding and assembly of RNPs? |
| cord-278081-tk7vn1v1 | Is it, for example, a conformational alteration of the ribosomal subunits stabilized by polyamines, or incomplete assembly of an RNP? |
| cord-278081-tk7vn1v1 | SSA/ Ro bound to misfolded RNAs stabilized with polyamines that prevent proper refolding? |
| cord-278081-tk7vn1v1 | What are the interactions and resulting structures of intronic Alu RNA with nucleolin? |
| cord-313161-07iwwsfz | The essential question is: which vector system to use? |
| cord-287286-4l963z2q | Are these changes in gene expression a result of a virus- host interaction disruption? |
| cord-287286-4l963z2q | But why are such changes occurring at a low frequency in infected populations? |
| cord-287286-4l963z2q | But why do only a few HPV infections result in malignancy? |
| cord-287286-4l963z2q | If the immature virus contains an incomplete shell, how is the virus released from the cell? |
| cord-000083-3p81yr4n | Between patients with HOMA- IR positive and negative, however, statistically no significant difference was found in terms of age, sex, etiology, Child- Pugh classification, spleen size, TNF-?, |
| cord-000083-3p81yr4n | Do we all failed in addressing socio- economic issues of cancer- sufferers? |
| cord-000083-3p81yr4n | IL-1? |
| cord-000083-3p81yr4n | IL-1? |
| cord-000083-3p81yr4n | IL-1? |
| cord-000083-3p81yr4n | IL-1? |
| cord-000083-3p81yr4n | In additon, we aimed to investigate the relation of insulin resistance in liver cirrhosis with such parameters as age, sex, etiology, Child- Pugh classification, spleen size, TNF-?, IL-1? |
| cord-000083-3p81yr4n | In additon, we aimed to investigate the relation of insulin resistance in liver cirrhosis with such parameters as age, sex, etiology, Child- Pugh classification, spleen size, TNF-?, IL-1? |
| cord-000083-3p81yr4n | In liver cirrhosis group, glucose, insulin, C- peptid, HOMA- IR, TNF-? |
| cord-000083-3p81yr4n | In patients with liver cirrhosis, the levels of glucose, insulin, C- peptid, HOMA- IR, TNF-?, IL-2RES, IL-6, CRP and Hs- CRP increase with respect to normal population. |
| cord-000083-3p81yr4n | In the study, it was also determined that the mechanism of insulin resistance development occurs independent of age, sex, etiology, Child- Pugh classification, spleen size, TNF-?, |
| cord-000083-3p81yr4n | The two groups were compared with each other in terms of glucose, insulin, C- peptid, HOMA- IR, TNF-?, |
| cord-000083-3p81yr4n | These two groups, i.e., HOMA- IR positive and HOMA- IR negative, were compared in terms of age, sex, etiology, Child- Pugh classification, spleen size, TNF-?, |
| cord-316434-mz4y5am2 | How will HPV vaccines affect cervical cancer? |
| cord-302895-471zei5o | Nidovirus helicase: a role in post- transcriptional quality control of viral mRNAs? |
| cord-302895-471zei5o | The nsp10 C- terminal domain: coupling ATPase and helicase activities? |
| cord-309642-wwaa6ls0 | Some aspects of pulmonary defence Retroviral transforming genes in normal cells? |
| cord-309642-wwaa6ls0 | The immunopathogenesis of dengue haemorrhagic fever Virally induced alterations in cellular permeability: A basis of cellular and physiological damage? |
| cord-313957-hviv5zar | The papain- like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme Biomolecules 2020 Deubiquitination, a new function of the severe acute respiratory syndrome coronavirus papain- like protease? |
| cord-315570-khm1veuv | How Far From Clinical Use? |
| cord-312001-8p7scli8 | Re- evaluation of the immunological Big Bang Pattern recognition receptors and control of adaptive immunity Approaching the asymptote? |
| cord-312001-8p7scli8 | The interferon response to intracellular DNA: Why so many receptors? |
| cord-308497-zltp8ei4 | An immediate connection from the heating coil to the coil submerged in ice should be used to avoid excess lysis.? |
| cord-308497-zltp8ei4 | When the bacteria are treated with the lysis buffer, the stirring should be very gentle and stirring is recommended at 10- 20 rpm; otherwise, the cells will be overlysed during the heating process.? |
| cord-310734-6v7oru2l | A comparison of bats and rodents as reservoirs of zoonotic viruses: Are bats special? |
| cord-310734-6v7oru2l | Important Reservoir Hosts of Emerging Viruses Bats and zoonotic viruses: Can we confidently link bats with emerging deadly viruses? |
| cord-319799-h9kot3og | : What is functional and what is junk? |
| cord-292031-weiwksh6 | : Can we kill them all? |
| cord-292031-weiwksh6 | : Is it possible? |
| cord-292031-weiwksh6 | The importance of the viable but non- culturable state in human bacterial pathogens Recent findings on the viable but nonculturable state in pathogenic bacteria Viable but non- culturable forms of food and waterborne bacteria: Quo vadis? |
| cord-292031-weiwksh6 | Where do emerging pathogens come from? |
| cord-314642-oobbdgzh | First, if this and other'alien'DNA came from some distantly related donor species of bacteria, what was the donor? |
| cord-314642-oobbdgzh | Second, is the potential mobility of the element in its present host a significant factor in the epidemiology of the diseases? |
| cord-304794-z2kx314h | Dr Jekyll or Mr Hyde? |
| cord-304794-z2kx314h | The Bloom's syndrome helicase unwinds G4 DNA Genome- wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability Human papillomavirus G- quadruplexes Spectrum of Epstein- Barr virus- associated diseases Role for G- quadruplex RNA binding by Epstein- Barr virus nuclear antigen 1 in DNA replication and metaphase chromosome attachment G- quadruplexes regulate Epstein- Barr virus- encoded nuclear antigen 1 mRNA translation Targeting G- quadruplexes in gene promoters: a novel anticancer strategy? |
| cord-304794-z2kx314h | The guanine- quadruplex aptamer 93del inhibits HIV-1 replication ex vivo by interfering with viral entry, reverse transcription and integration Cellular uptake of ODNs in HIV-1 human- infected cells: a role for viral particles in DNA delivery? |
| cord-306904-8iteddug | Properties of the decarboxylated gamma- carboxyglutamic acid protein from calf bone Coordinated transcriptional regulation of Hspa1a gene by multiple transcription factors: crucial roles for HSF-1 Plasma levels of Hsp70 and anti- Hsp70 antibody predict risk of acute coronary syndrome Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology Heat shock proteins in breast cancer progression- a suitable case for treatment? |
| cord-306904-8iteddug | Reconstituted human myosin light chain phosphatase reveals distinct roles of two inhibitory phosphorylation sites of the regulatory subunit, MYPT1 Structural and functional analysis of the GerD spore germination protein of Bacillus species Spores of Bacillus subtilis: their resistance to and killing by radiation, heat and chemicals Germination of spores of Bacillales and Clostridiales species: mechanisms and proteins involved Spore germination How do spores germinate? |
| cord-306904-8iteddug | The deletion of exon 3 in the cardiac ryanodine receptor is rescued by beta strand switching ATPinduced dimerization of the FF epsilon subunit from Bacillus PS3: a hydrogen exchange- mass spectrometry study Crystal structure of the epsilon subunit of the proton- translocating ATP synthase from Escherichia coli Phosphorylation of the cyclin CaPcl5 modulates both cyclin stability and specific recognition of the substrate Principles of CDK regulation Cyclin specificity: how many wheels do you need on a unicycle? |
| cord-282610-zim7nond | Archaea are interactive components of complex microbiomes Measuring the archaeome: detection and quantification of archaea signatures in the human body Uncovering Earth's virome Bacteriophage transcytosis provides a mechanism to cross epithelial cell layers Does the microbiome and virome contribute to myalgic encephalomyelitis/ chronic fatigue syndrome? |
| cord-282610-zim7nond | Bacteria- tohuman protein networks reveal origins of endogenous DNA damage Extracellular vesicles and viruses: Are they close relatives? |
| cord-282610-zim7nond | IMG/ VR: a database of cultured and uncultured DNA Viruses and retroviruses IMG/ VR Database Triples in Size Persistent elevated expression of cytokine transcripts in ganglia latently infected with herpes simplex virus in the absence of ganglionic replication or reactivation Function and functional redundancy in microbial systems Functional redundancy of soil microbiota-does more always mean better? |
| cord-282610-zim7nond | Stealth Pathogens Parallels between post- polio fatigue and chronic fatigue syndrome: a common pathophysiology? |
| cord-282610-zim7nond | The Jarisch- Herxheimer reaction in syphilis: could molecular typing help to understand it better? |
| cord-282610-zim7nond | The human microbiome project Does blood of healthy subjects contain bacterial ribosomal DNA? |
| cord-311349-145kwny3 | Is anti- doping analysis so far from clinical, legal or forensic targets? |
| cord-311349-145kwny3 | what next? |
| cord-264456-wjpc6zgq | ( C6ORF130, OARD1) Hydrolase DNA repair? |
| cord-264456-wjpc6zgq | ( PARP12) MAR Translation[ 31] NF- κB signaling? |
| cord-264456-wjpc6zgq | A ribonucleoprotein particle involved in drug resistance? |
| cord-264456-wjpc6zgq | Autophagy? |
| cord-264456-wjpc6zgq | Multidrug resistance? |
| cord-264456-wjpc6zgq | [ 15][ 16] Innate immunity? |
| cord-264456-wjpc6zgq | [ 32] GSK3β signaling? |
| cord-264456-wjpc6zgq | [ 33] Regulation of apoptosis[ 34] Inflammation? |
| cord-264456-wjpc6zgq | [ 35] Autophagy? |
| cord-312278-rin733w4 | COVID-19: what is next for public health? |
| cord-312278-rin733w4 | The SARS, MERS and novel coronavirus( COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? |
| cord-312278-rin733w4 | are they closely related? |
| cord-324944-ixh3ykrc | Not Applicable;"?": unknown;"NAATs": |
| cord-325280-4whzcmqv | what's the future holding for us? |
| cord-319884-d8n0aokl | Is SELDI- TOF a valid tool for diagnostic biomarkers? |
| cord-319884-d8n0aokl | Why 3-D? |
| cord-318276-so5jooj0 | Borst, l?( 1986). |
| cord-318276-so5jooj0 | How do eucaryotic ribosomes select initiation regions in messenger RNA? |
| cord-001835-0s7ok4uw | 3) Can an exhaustive statistical scan of a large, recent dataset identify new side chain interactions at helix termini? |
| cord-001835-0s7ok4uw | A Promoter or Inhibitor for IAPP aggregation? |
| cord-001835-0s7ok4uw | An empirical framework for binary interactome mapping Estimating the size of the human interactome Coming to peace with protein complexes? |
| cord-001835-0s7ok4uw | Are they essential in carrying out a specific cellular function? |
| cord-001835-0s7ok4uw | But the general effects on traits relevant at atomic/ residue resolutions have been less studied, and one fundamental issue remains unsolved: to what extent are proteins forced into interactions with highly concentrated solutes, and with what direct consequences? |
| cord-001835-0s7ok4uw | Can Bio- functionalities be deciphered from protein sequence information using computational approaches? |
| cord-001835-0s7ok4uw | Can site- directed mutagenesis shed light on the refolding pattern of human glucose 6-phosphate dehydrogenase( G6PD)? |
| cord-001835-0s7ok4uw | Can the structure of a protein( H3.1) depend on the treatment of a solvent medium( explicit vs effective) in a coarse- grained computer simulation? |
| cord-001835-0s7ok4uw | Do they play a regulatory role in controlling the on and off of a certain cellular process? |
| cord-001835-0s7ok4uw | How did enzymes, the catalysts of many crucial cellular processes, achieve this cold adaptation? |
| cord-001835-0s7ok4uw | In a protein engineering context, do we need to take into account the dynamics in order to maximize the fitness and function of the resulting proteins? |
| cord-001835-0s7ok4uw | Is there evolutionary pressure to conserve dynamics? |
| cord-001835-0s7ok4uw | Is this necessary to retain functionality, as it has been suggested? |
| cord-001835-0s7ok4uw | Protein engineering: what's next? |
| cord-001835-0s7ok4uw | Questions under- investigation includes what are the effects of mutations( e.g. b- and g- synuclein), how does the structure of an isolated ASN chain change in presence of many interacting protein chains, and how do they organize over the multiple length scales? |
| cord-001835-0s7ok4uw | To what extent are helix- terminal motifs that include multiple amino acids likely to represent genuine cooperative interactions between side chains, rather than chance alignments? |
| cord-001835-0s7ok4uw | Which particular helix- terminal loop geometries are favored by each side chain interaction? |
| cord-328206-iylw1bvw | Then we optimized annealing temperature( from 52uC260uC) and determined the compromise annealing temperature used for multiplex detection was 58?. |
| cord-321762-7kiahjyy | What appears to be lost in the process is the target: How useful are these representations to the practicing biologist? |
| cord-312522-mymgnf8z | In other words, a patient with intrinsically high levels of mef(A) in her healthy microbiome would The question of whether our RPA assay would distinguish infection from colonization is related to a larger debate in the diagnostic field: when is a molecular assay too sensitive? |
| cord-312522-mymgnf8z | The microbiome in precision medicine: the way forward Precision antimicrobial therapeutics: the path of least resistance? |
| cord-320015-lbr2q4qh | Characterization of primary and memory CD8 T- cell responses against ranavirus( FV3) in Xenopus laevis Xenopus laevis: A possible vector of Ranavirus infection? |
| cord-320015-lbr2q4qh | a purine nucleoside phosphorylase Genomic sequence of a ranavirus( family Iridoviridae) associated with salamander mortalities in North America Poxviruses: past, present, and future How similar are poxviruses? |
| cord-328899-kog99kk5 | Animals receiving corrected to achieve clinical benefit? |
| cord-023055-ntbvmssh | -%~~ specific? |
| cord-023055-ntbvmssh | D61 and D62 are 9 and 13 bp long, are frequently recombine as D,1/ D62? and reveal exonucleolytic trimning with extensive"N"segment addition. |
| cord-023055-ntbvmssh | In support of this possibility, thymectomized&+( a x b)F1 chimeras given strain J? marrow cells and a strain thymus graft( irradiated) show no detectable tolerance to host- type strain b determinants: the strain& CD4+ cells differentiating in these chimeras give strong MLR to strain b and do not show deletion of v 11+ cells. |
| cord-023055-ntbvmssh | The efect of these TCR differences on recognition was assessed using a pane? |
| cord-023055-ntbvmssh | The existence of"primed"T cells in phenotypically tolerant animals raises the possibility that precocious activation of TR1( by neonatal exposure to tolerogen?) suppresses the later emergence of T,,, which would be expected to contain the cells responsible for graft rejection. |
| cord-023055-ntbvmssh | The increase peaked at 2 min and returned almost to baseline by 10 mi?. |
| cord-023055-ntbvmssh | Us& this tecfinolosy we have begun to characterize the irmnUne reqonse to individual peptide antigens.? |
| cord-023055-ntbvmssh | Us& this& logy we have begun to characterize the innume response to individual Peptide antigens.? |
| cord-023055-ntbvmssh | We have extended these exper- to inta? |
| cord-023055-ntbvmssh | We reasoned that given the potential for direct peptide/ class?'&$% ation observed in vifro, OVA2s,-2ra may induce CTL after in vivo priming. |
| cord-023055-ntbvmssh | c a l l y autoreactive T cell:? |
| cord-023055-ntbvmssh | e human nutoinimiine tlisrases maintdin:? |
| cord-288187-84oj3xtp | Emergence, Detection and Response Mail- order CRISPR kits allow absolutely anyone to hack DNA The ins and outs of DNA fingerprinting of infectious fungi Laboratory procedures for the epidemiological analysis of microorganisms PulseNet: the molecular subtyping network for foodborne bacterial disease surveillance, United States How to select and interpret molecular strain typing methods for epidemiological studies of bacterial infections: a review for healthcare epidemiologists Overview and significance of molecular methods: what role for molecular epidemiology? |
| cord-288187-84oj3xtp | The occurrence of a disease at more than an endemic level may stimulate an investigation during which investigators may ask three questions( Gordis, 1996): Who has the disease? |
| cord-288187-84oj3xtp | What is next generation sequencing? |
| cord-288187-84oj3xtp | When did the disease occur? |
| cord-288187-84oj3xtp | When should fingerprinting be used? |
| cord-288187-84oj3xtp | Where did the cases arise? |
| cord-330581-g5r2b043 | Role of immune activation HIV-1 infection and AIDS dementia are influenced by a mutant MCP-1 allele linked to increased monocyte infiltration of tissues and MCP-1 levels Tumor necrosis factor- a induced expression of monocyte chemoattractant JE via fos and jun genes in clonal osteoblastic MC3T3-E1 cells Activation of AP-1 signal transduction pathway by SARS coronavirus nucleocapsid protein Macrophage activation and HIV infection: can the Trojan horse turn into a fortress? |
| cord-316033-xg8eb2nm | A deep insight into the sialotranscriptome of the gulf coast tick, Amblyomma maculatum PCR- RFLP analyses of leishmania species causing cutaneous and mucocutaneous leishmaniasis revealed distribution of genetically complex strains with hybrid and mito- nuclear discordance in Ecuador Phylogenomic and biogeographic reconstruction of the Trichinella complex Circos: an information aesthetic for comparative genomics Fast gapped- read alignment with bowtie 2 Inference of population structure using dense haplotype data Signatures of mito- nuclear discordance in Schistosoma turkestanicum indicate a complex evolutionary history of emergence in Europe Popart: full- feature software for haplotype network construction Are Ascaris lumbricoides and Ascaris suum a single species? |
| cord-316033-xg8eb2nm | The genome of Onchocerca volvulus, agent of river blindness Disentangling hybridization and host colonization in parasitic roundworms of humans and pigs Landscape genetics reveals focal transmission of a human macroparasite Ascaris lumbricoides, Ascaris suum, or"Ascaris lumbrisuum"? |
| cord-328940-8vtcochx | We applied mFold( http://unafold.rna.albany.edu/? qϭmfold/ dna- folding- form) to model the secondary structures of ssDNA surrounding and including Chi AD, within the GC/ AT transition zone at HVL2. |
| cord-300061-l2pfl776 | Does Z- curve have over dimensionality? |
| cord-300061-l2pfl776 | Inscribed sphere or circumscribed sphere? |
| cord-300061-l2pfl776 | Is S equivalent to H? |
| cord-300061-l2pfl776 | Mutational patterns can not explain genome composition: are there any neutral sites in the genomes of bacteria? |
| cord-300061-l2pfl776 | Mutational patterns can not explain genome composition: are there any neutral sites in the genomes of bacteria? |
| cord-323973-wszo9s3d | Once- in- a- Century Pandemic? |
| cord-323973-wszo9s3d | One can not help but wonder: why has the development and deployment of practical POC- PCR testing taken so much time? |
| cord-315164-nidgnvvi | A Review of the Evidence Les adénovirus non- humains: Un risque zoonotique? |
| cord-315164-nidgnvvi | Neutralizing antibodies against 33 human adenoviruses in normal children in Rome Are adenoviruses zoonotic? |
| cord-315164-nidgnvvi | nonhuman primate or bat adenoviruses pose a risk for human health? |
| cord-332844-2se4d1yp | Fauquet Japanese encephalitis virus: molecular biology and vaccine development Control of Japanese encephalitis- within our grasp? |
| cord-328460-thx9zh11 | : Is a true lab- on- a- chip possible? |
| cord-328460-thx9zh11 | What's next? |
| cord-308687-wrzzb9cy | Canada( ECCC)'s import restrictions on salamanders Will trade bans stop a deadly salamander plague from invading the US? |
| cord-308687-wrzzb9cy | The question in this paper is therefore: can pooling swab samples or using eDNA place routine surveillance in reach? |
| cord-308687-wrzzb9cy | Trends in US imports of amphibians in light of the potential spread of chytrid fungus,( Bd), and implications for conservation Qualitative risk analysis of introducing Batrachochytrium dendrobatidis to the UK through the importation of live amphibians Can environmental dna be used for aquatic biosecurity in the aquarium fish trade To pool or not to pool? |
| cord-308687-wrzzb9cy | how can global spread be prevented? |
| cord-331557-8axi74nn | key: cord-331557- 8axi74nn authors: Raoult, Didier; Fournier, Pierre Edouard; Drancourt, Michel title: What does the future hold for clinical microbiology? |
| cord-335607-gv96hlw6 | But what is the fate of DNA materials in the future? |
| cord-294877-bbs8a8jz | A novel organic- inorganic hybrid monolith for trypsin immobilization Advances in enzyme immobilisation Strategy and success for the directed evolution of enzymes Chemical modification in the creation of novel biocatalysts Enzyme engineering for enantioselectivity: from trial- and- error to rational design? |
| cord-294877-bbs8a8jz | For example, how can we find or create enzymes that catalyze the desired chemical reaction of interest, even those not existing in nature? |
| cord-294877-bbs8a8jz | How can we create multiple- enzyme biocatalytic systems required for multistep biosynthesis of complex natural and unnatural products? |
| cord-294877-bbs8a8jz | How can we effectively integrate non- native pathways into the metabolism of a host? |
| cord-294877-bbs8a8jz | How can we improve the stress tolerance of biocatalytic systems to industrial reaction conditions? |
| cord-294877-bbs8a8jz | Thus, they often fail to address a fundamental scientific question: how are biological processes, most of which are chemical reactions catalyzed by enzymes, coordinated in space and time to produce a living organism[ 2]? |
| cord-334082-fyxn0g3v | Expression of animal virus genomes Here a virus, there a virus, everywhere the same virus? |
| cord-309083-ew9cwiw0 | An etiological study on mass mortality of cultured colorcarp juveniles showing edema A survey of koi herpesvirus and carp edema virus in colorcarp cultured in Niigata Prefecture Situation and tendency of the fishery vaccine development A herpesvirus associated with mass mortality of juvenile and adult koi, a strain of common carp Current knowledge on koi herpesvirus( KHV): a review KHV, CNGV or CyHV-3, which is the koi/ carp killer? |
| cord-309083-ew9cwiw0 | Another potential carp killer? |
| cord-309083-ew9cwiw0 | Do wild fish species contribute to the transmission of koi herpesvirus to carp in hatchery ponds? |
| cord-309083-ew9cwiw0 | What happens to the DNA vaccine in fish? |
| cord-319116-2ts6zpdb | Elevated levels of G- quadruplex formation in human stomach and liver cancer tissues G- quadruplex- binding small molecules ameliorate C9orf72 FTD/ ALS pathology in vitro and in vivo G- quadruplex structures and their interaction diversity with ligands Structure, location and interactions of G- quadruplexes Telomere G- quadruplex as a potential target to accelerate telomere shortening by expanding the incomplete end- replication of telomere DNA Telomeric G- quadruplex architecture and interactions with potential drugs Human telomeric G- quadruplex: the current status of telomeric G- quadruplexes as therapeutic targets in human cancer Cell cycle regulation of G- quadruplex DNA structures at telomeres G- quadruplexes in human promoters: a challenge for therapeutic applications G4 DNA in ras genes and its potential in cancer therapy Small molecules targeting c- Myc oncogene: promising anti- cancer therapeutics Making sense of G- quadruplex and i- motif functions in oncogene promoters G- quadruplex structures in the human genome as novel therapeutic targets Targeting G- quadruplexes in gene promoters: a novel anticancer strategy? |
| cord-319116-2ts6zpdb | Targeting unimolecular G- quadruplex nucleic acids: a new paradigm for the drug discovery? |
| cord-319116-2ts6zpdb | radioresistance of D. radiodurans involves G4 DNA- mediated regulation Mapping and characterization of G- quadruplexes in Mycobacterium tuberculosis gene promoter regions G- quadruplexes in pathogens: a common route to virulence control? |
| cord-330800-s91zfzfi | Molecular diagnosis of infectious diseases using cytological specimens Point- counterpoint: is the era of viral culture over in the clinical microbiology laboratory? |
| cord-330800-s91zfzfi | Where do we go from here? |
| cord-329155-ddpfox68 | Could intermittent energy restriction and intermittent fasting reduce rates of cancer in obese, overweight, and normal- weight subjects? |
| cord-329155-ddpfox68 | The connection for cancer therapy? |
| cord-340781-z348xbn0 | Worldwide burden of cancer attributable to HPV by site, country and HPV type Estimate of the global burden of cervical adenocarcinoma and potential impact of prophylactic human papillomavirus vaccination HPV vaccination: the promise& problems Pros, cons, and ethics of HPV vaccine in teens- Why such controversy? |
| cord-341062-k3vjqumq | its roles in cyclin D1 expression and cancer progression Subtype- specific alterations of the Wnt signaling pathway in breast cancer: clinical and prognostic significance N- Myc interactor) inhibits Wnt/ beta- catenin signaling and retards tumor growth Dick- kopf1: a tumor suppressor or metastasis promoter? |
| cord-297790-tpjxt0w5 | A comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special? |
| cord-297790-tpjxt0w5 | A molecular phylogeny for bats illuminates biogeography and the fossil record Host and viral traits predict zoonotic spillover from mammals Are disease reservoirs special? |
| cord-297790-tpjxt0w5 | Are bats exceptional viral reservoirs? |
| cord-297790-tpjxt0w5 | Do our life history traits make us susceptible to generating damaging immune responses to RNA viruses or does the physiology of bats make them particularly tolerant or resistant? |
| cord-297790-tpjxt0w5 | Mass extinctions, biodiversity and mitochondrial function: are bats'special'as reservoirs for emerging viruses? |
| cord-297790-tpjxt0w5 | What links bats to emerging infectious diseases? |
| cord-331718-rjggiklf | Meeting at the synapse? |
| cord-331718-rjggiklf | What do we know? |
| cord-332654-nav15g8k | Can we use interleukin-6( IL-6) blockade for coronavirus disease 2019( COVID-19)-induced cytokine release syndrome( CRS)? |
| cord-332654-nav15g8k | hsa- miR-25- 3p suppresses the expression and drug induction of CYP2B6 in human hepatocytes Hydroxychloroquine cardiotoxicity presenting as a rapidly evolving biventricular cardiomyopathy: key diagnostic features and literature review Impact of OATP transporters on pharmacokinetics Phagocytosis of retinal rod and cone photoreceptors Retinopathy due to antimalarial drugs in patients with connective tissue diseases: are they so innocent? |
| cord-335864-392xmrq0 | How are circRNAs translated by non- canonical initiation mechanisms? |
| cord-335864-392xmrq0 | The trimethylguanosine cap structure of U1 snRNA is a component of a bipartite nuclear targeting signal Non- coding RNA: what is functional and what is junk? |
| cord-328518-umvk59dc | A comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special? |
| cord-328518-umvk59dc | Do nonhuman primate or bat adenoviruses pose a risk for human health? |
| cord-328518-umvk59dc | Mammal species of the world: a taxonomic and geographic reference How many species of mammals are there? |
| cord-332379-340wczmq | How do general practitioners manage eye disease in the community? |
| cord-332379-340wczmq | Human adenovirus species D types 15, 29, 56, and 69 Association of adenovirus with the microtubule organizing center Endocytosis via caveolae: Alternative pathway with distinct cellular compartments to avoid lysosomal degradation? |
| cord-297078-pxggjaby | Did DNA replication evolve twice independently? |
| cord-297078-pxggjaby | Early evolution: prokaryotes, the new kids on the block Methyl- RNA: an evolutionary bridge between RNA and DNA? |
| cord-297078-pxggjaby | On one hand the late stages of the RNP world appear complex, so how could a small RNA genome have supported both protein synthesis and have evolved enzymes as chemically''sophisticated''as ribonucleotide reductases( Poole, Penny, and Sjöberg 2000)? |
| cord-297078-pxggjaby | On the other hand, how feasible is the contention that the LUCA had an RNA genome? |
| cord-297078-pxggjaby | The third is somewhat dependent on the first; assuming RNA repair was present, was it involved in quality control, genome replication, or both? |
| cord-297078-pxggjaby | mRNA Proofreading and Repair: Clues that the Last Universal Common Ancestor Possessed an RNA Genome? |
| cord-343029-85ga6r7d | COVID-19, an infertility risk? |
| cord-327170-rv0efgg2 | A minor groove binder probe real- time PCR assay for discrimination between type 2-based vaccines and field strains of canine parvovirus Characterisation of the canine parvovirus type 2 variants using minor groove binder probe technology Diagnostic tools based on minor groove binder technology for rapid identification of vaccine and field strains of canine parvovirus type 2b First detection of canine parvovirus type 2c in pups with haemorrhagic enteritis in Spain Canine parvovirus infection: which diagnostic test for virus? |
| cord-327170-rv0efgg2 | A simple touch- down polymerase chain reaction for the detection of canine parvovirus and feline panleukopenia virus in feces Antigenic and genetic analysis of canine parvoviruses in southern Africa Emergence and recent evolution of canine parvovirus Evolution of canine parvovirus- a need for new vaccines? |
| cord-327170-rv0efgg2 | Characterization of the feline host range and a specific epitope of feline panleukopenia virus Evolution of the feline- subgroup parvoviruses and the control of canine host range in vivo Antigenic type distribution among canine parvoviruses in dogs and cats in Germany Survey on viral pathogens in wild red foxes( Vulpes vulpes) in Germany with emphasis on parvoviruses and analysis of a DNA sequence from a red fox parvovirus Distribution of antigenic types of canine parvovirus in Switzerland, Austria and Germany Evidence of parvovirus replication in cerebral neurons of cats Do canine parvoviruses affect canine neurons? |
| cord-343775-tcljwdlo | A multiplex PCR for detection of poxvirus and papillomavirus in cutaneous warts from live birds and museum skins 110 years of Avipoxvirus in the Galapagos Islands Monkeypox: an emerging infection for humans? |
| cord-345494-8lcdx719 | The past and present threat of rickettsial diseases to military medicine and international public health Rickettsial infections- a threat to travellers? |
| cord-342782-xty16m8w | Severe Community- Acquired Pneumonia Caused by Human Adenovirus in Immunocompetent Adults: A Multicenter Case Series Severe Infections with Human Adenovirus 7d in 2 Adults in Family Etiology of severe pneumonia in Ecuadorian children Severe community- acquired adenovirus pneumonia treated with oral ribavirin: a case report Antiadenovirus drug discovery: potential targets and evaluation methodologies Repurposing of Anticancer Drugs for the Treatment of Bacterial Infections Drug Repurposing: New Treatments for Zika Virus Infection? |
| cord-338812-q24jycgk | What's new in the nucleolus? |
| cord-344749-omzhhr0k | The pathogenesis of infection with minute virus of mice depends on expression of the small nonstructural protein NS2 and on the genotype of the allotropic determinants VP1 and VP2 Viruses Immunity to Avian leukosis virus: where are we now and what should we do? |
| cord-347992-coby2m6e | In vitro selection procedures for identifying DNA and RNA aptamers targeted to nucleic acids and proteins Berzal- Herranz, A. RNA selection and evolution in vitro: powerful techniques for the analysis and identification of new molecular tools Aptamers: a new class of oligonucleotides in the drug discovery pipeline? |
| cord-345903-ggkn1w5y | Do mutator mutations fuel tumorigenesis? |
| cord-307914-lgprrwee | ( Gowen et al., 2007)? |
| cord-307914-lgprrwee | , 2009)? |
| cord-307914-lgprrwee | -I given that RIG- I senses the 5 0 diphosphate terminus? |
| cord-307914-lgprrwee | : DNase II deficiency prevents activation of autoreactive B cells by double- stranded DNA endogenous ligands Toll- like receptor 3 in viral pathogenesis: friend or foe? |
| cord-307914-lgprrwee | C a robust activator of MDA5 while many other defined, long dsRNAs such as poly(A: U) are not( Colby and Chamberlin, 1969; Pichlmair et al., 2009)? |
| cord-307914-lgprrwee | The interferon response to intracellular DNA: why so many receptors? |
| cord-305143-mqd4ioj4 | Do they function in host interaction? |
| cord-305143-mqd4ioj4 | Do they possess as of yet undiscovered, but shared protein domains? |
| cord-305143-mqd4ioj4 | Do they result in altered pathology or clinical symptoms? |
| cord-305143-mqd4ioj4 | Our automated approach provides a starting point for the systematic computational and experimental study of these species- and strain- specific proteins- studies, which eventually will provide answers to such questions as: Are these species- and strain- specitic proteins essential under certain conditions? |
| cord-305143-mqd4ioj4 | Similarly, what would be the consequence of adding a Cterminal GlyL_C domain to the gL protein of VZV( which contains one Herpes_UL1 domain), and so making it similar to the gL protein found in HSV-1 and HSV-2( which has a Herpes_UL1--GlyL_C architecture)? |
| cord-305143-mqd4ioj4 | This raises the question-are such share named truly justified for proteins composed of unrelated domains? |
| cord-347569-9fvbshz2 | A review on current status of antiviral siRNA Combinatorial RNAi: a winning strategy for the race against evolving targets? |
| cord-344321-fjer281d | Sequential loss of tumor vessel pericytes and endothelial cells after inhibition of platelet- derived growth factor B by selective aptamer AX102 PDGFR? |
| cord-346965-0oq2n0af | Protein clefts in molecular recognition and function From protein structure to biochemical function? |
| cord-016095-jop2rx61 | What can teaching, ex cathedra, do to guide the researcher? cord-016095-jop2rx61 , Stanislas DEHAENE( b. 1965), Daniel DENNETT( b. 1942) and others, that thought is not transcendent, and that it is intrinsically dependent on the brain, which is considered to be a neurochemical system, and thus look for the secret of the individuation of the human being in brain information storage mechanisms with retrocontrol loops associated with subtle neuron architectures, or, in short, refer to a sort of TURING machine? cord-016095-jop2rx61 Are the stakes involved in a particular experiment, in terms of the acquisition of new knowledge, worth the suffering of an animal used in that experiment? cord-016095-jop2rx61 At a scientific meeting held in Sheffield, England, in January of 2005 63, with the theme Systems biology: will it work?, an argumentative discussion of the advantages as well as the disadvantages of an integrated, mathematized biology was useful in that it included a reminder that most of the parameters used insystems biology"come from studies that are carried out in vitro on purified enzymes, and that it is not sufficient to know the value of the Michaelian parameters( V max and K m) in order to reach biological reality. |
| cord-016095-jop2rx61 | At what stage of embryo development is it possible to remove ES cells for experimental purposes? |
| cord-016095-jop2rx61 | How can the sum of the scattered experimental data that we have concerning the catalytic capabilities of a multitude of enzymes of cellular origin be integrated into the operation of a cell? |
| cord-016095-jop2rx61 | How can we envisage the gene- enzyme relationship according to current evidence concerning the complexity of the genetic message? |
| cord-016095-jop2rx61 | How could this be true if the teaching faculty did not itself participate in scientific creation? |
| cord-016095-jop2rx61 | In a text entitled Why genetic engineering should continue its battle 31, James WATSON writes of his confusion when faced with a choice that is likely to become more and more insistent over the years:"Dare we be entrusted with improving on the results of several million years of Darwinian natural selection? |
| cord-016095-jop2rx61 | In his What is Bioethics? |
| cord-016095-jop2rx61 | Innumerable cargoes have already reached port, but what will be the destiny of this precious merchandise? |
| cord-016095-jop2rx61 | Is it not necessary to ensure that the experimental protocol is well- documented, that it is not redundant, or even that it has been the subject of previous studies carried out on cells in culture? |
| cord-016095-jop2rx61 | Should"systems biology"be regarded as a resurgence of a physiology that has been somewhat neglected over the last few decades, but has been reinvigorated by a salutary hybridization of biologists and model- makers? |
| cord-016095-jop2rx61 | This example highlights a harrowing ethical dilemma: should we not treat a patient whose illness is likely to be fatal, or attempt a therapy that may save the patient, without having any formal assurance of its success? |
| cord-016095-jop2rx61 | With such an innovation, an unexpected field of exploration has opened up to research in domains as far apart as pharmacology and the science of evolution, giving rise to burning questions: could such non- natural proteins have therapeutic properties? |
| cord-016095-jop2rx61 | could they give a selective advantage to the organisms that host them? |
| cord-016095-jop2rx61 | or do the human germ cells represent on the contrary Rubicons that geneticists will never dare to cross? |
| cord-350807-qdq96723 | Human herpesvirus 6 Herpesvirus infections in organ transplant recipients Clinical impact of HSV-1 detection in the lower respiratory tract from hospitalized adult patients Quantitative detection of Epstein- Barr virus in bronchoalveolar lavage from transplant and nontransplant patients Detection of herpesvirus EBV DNA in the lower respiratory tract of ICU patients: a marker of infection of the lower respiratory tract? |
| cord-335839-wgdqu1s1 | The next century of children's health care Communication as a bridge to build a sound doctor- patient/ parent relationship The human genome project Implications of human genome project for pediatrics Prenatal diagnosis and selective abortion: a challenge to practice and policy Gene therapy: principles, practice, problems and prospects Sheep cloned by nuclear transfer from a cultured cell line Viable offspring derived from fetal and adult mammalian cells Clinical applications of bloodderived and marrow- derived stem cells for non- malignant diseases Hematopoietic stem cell transplantation: a global perspective Multi- organ multi- lineage engraftment by a single bone marrow derived stem cell Diagnostic applications of DNA probes DNA vaccines for non- infectious diseases: new treatments for tumour and allergy Improved non- contact optimal sensor for detection of glucose concentration and indication of dehydration level Wearable electronic devices monitor vital signs, activity level, and more Single- pulse standoff Raman detection of chemicals from 120 m distance during daytime A new definition of functional foods by FFC: what makes the new definition unique? |
| cord-335839-wgdqu1s1 | recent developments Lasers used in dermatology Artificial blood Broad- spectrum antiviral therapeutics Robot- assisted surgery: the future is here Telepediatrics in Canada: an overview One hundred years of telemedicine: does this new technology have a place in pediatrics Telemedicine and Child Health Blessing or curse? |
| cord-264814-v4wnmg03 | Antigenspecific human T- cell responses and T cell- dependent production of human antibodies in a humanized mouse model A mouse model of SARS- CoV-2 infection and pathogenesis Adaptation of SARS- CoV-2 in BALB/ c mice for testing vaccine efficacy Vaccine adjuvants: smart components to boost the immune system Correlates of adjuvanticity: a review on adjuvants in licensed vaccines Potential adjuvants for the development of a SARS- CoV-2 vaccine based on experimental results from similar coronaviruses Development of SARS- CoV-2 vaccines: should we focus on mucosal immunity? |
| cord-264814-v4wnmg03 | Available online at A single- dose live- attenuated YF17D- vectored SARS- CoV2 vaccine candidate DNA vaccines- how far from clinical use? |
| cord-264814-v4wnmg03 | COVID-19: are neutralizing antibodies neutralizing enough? |
| cord-264814-v4wnmg03 | Is BCG vaccination causally related to reduced COVID-19 mortality? |
| cord-264814-v4wnmg03 | Protection or Hyper- Activation? |
| cord-264814-v4wnmg03 | T Cell Adaptive Immunity: Protection, Immune Suppression or Disease Enhancement? |
| cord-264814-v4wnmg03 | The Spread of COVID-19 and the BCG Vaccine: a Natural Experiment in Reunified Germany SARS- CoV-2 rates in BCGvaccinated and unvaccinated young adults BCG- induced trained immunity: can it offer protection against COVID-19? |
| cord-264814-v4wnmg03 | With Task Force Vaccine Safety Expert A controlled human infection model of group a streptococcus pharyngitis: which strain and why? |
| cord-264814-v4wnmg03 | a six- year follow- up study Recovery from the middle east respiratory syndrome is associated with antibody and T- cell responses Immune cell profiling of COVID-19 patients in the recovery stage by single- cell sequencing Immunology of COVID-19: current state of the science Molecular basis of coronavirus virulence and vaccine development SARS vaccines: where are we? |
| cord-264814-v4wnmg03 | how first exposure shapes lifelong anti- influenza virus immune responses Original antigenic sin and respiratory syncytial virus vaccines What about the original antigenic sin of the humans versus SARS- CoV-2? |
| cord-264814-v4wnmg03 | mSphere Regulatory T cells in arterivirus and coronavirus infections: do they protect against disease or enhance it? |
| cord-288960-v6l6o5va | I interferon responses in vivo Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-?? |
| cord-288960-v6l6o5va | I interferon responses in vivo Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-?? |
| cord-288960-v6l6o5va | Recent approaches to intracellular delivery of drugs and dna and organelle targeting IFN?? |
| cord-288960-v6l6o5va | Recent approaches to intracellular delivery of drugs and dna and organelle targeting IFN?? |
| cord-288960-v6l6o5va | The regional function of cGAS/ STING signal in multiple organs: one of culprit behind systemic lupus erythematosus? |
| cord-288960-v6l6o5va | Type I interferon in the pathogenesis of lupus Type I interferon: friend or foe? |
| cord-288960-v6l6o5va | interferon responses are impaired in latently HIV infected cells HIV-1 and interferons: who's interfering with whom? |
| cord-288960-v6l6o5va | lessons learned from antagonism of STING signalling during RNA virus infection E2 proteins of high risk human papillomaviruses down- modulate STING and IFN-?? |
| cord-288960-v6l6o5va | lessons learned from antagonism of STING signalling during RNA virus infection E2 proteins of high risk human papillomaviruses down- modulate STING and IFN-?? |
| cord-351197-xv6ymc4l | What is for dinner? |
| cord-352619-s2x53grh | A review of porcine circovirus 2-associated syndromes and diseases Porcine circovirus diseases Experimental reproduction of severe wasting disease by co- infection of pigs with porcine circovirus and porcine parvovirus Concurrent infections are important for expression of porcine circovirus associated disease Circovirus in domestic and wild carnivores: An important opportunistic agent? |
| cord-353297-jizitnfl | Did bioweapons test cause a deadly smallpox outbreak? |
| cord-346450-x1u567ss | How do all those signals integrate? |
| cord-346450-x1u567ss | There are still open questions on what determines the activating or regulatory outcome; Is it conditioned by the PRR expression profile of surrounding cells? |
| cord-325750-x7jpsnxg | , Mandrillus leucophaeus Isolation of a cDNA from the virus responsible for enterically transmitted non- A, non- B hepatitis Quantitative monitoring of gene expression patterns with a complementary DNA microarray Viral discovery and sequence recovery using DNA microarrays Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant Prostate cancer: XMRV-contaminant, not cause? |
| cord-325750-x7jpsnxg | For example, how far has this new viral metagenomics discipline evolved in its first decade? |
| cord-325750-x7jpsnxg | The discovery of the poliovirus Smallpox and Its Eradication The Greatest Killer-Smallpox in History Discovery of the first virus, the tobacco mosaic virus: 1892 or 1898? |
| cord-325750-x7jpsnxg | What has been learned so far that can be applied to viral discovery and the forecasting of future viral outbreaks? |
| cord-349672-2kt7xw8i | A Novel Candidate Gene in Juvenile Myoclonic Epilepsy? |
| cord-349672-2kt7xw8i | topoisomerase I conserved for interaction with a specific cytosine base to facilitate DNA cleavage Synthesizing topological structures containing RNA Type IA topoisomerases: A simple puzzle? |
| cord-347472-n6811ens | Controls are useful; why not add more? |
| cord-347472-n6811ens | Why change the assay when one could fix the input? |
| cord-000718-7whai7nr | : Are they the clues in determination of tumor grade? |
| cord-000718-7whai7nr | : Do we need a cut- off? |
| cord-000718-7whai7nr | A marker for BRAF mutated colorectal carcinomas? |
| cord-000718-7whai7nr | After two mediastinal biopsies with unspecific features( Castleman disease?), the diagnostic one showed fibrosis, abundant small reactive lymphocytes( CD20+/CD3+) and areas with diffuse small- medium size lymphocytes positive for CD3, TdT, CD34, CD7, LMO2 and high Ki67. |
| cord-000718-7whai7nr | Are HMB-45 and MIB1 results reliable for safe diagnosis of nevi? |
| cord-000718-7whai7nr | Can we rely on alternative sampling method of radical prostatectomy specimens? |
| cord-000718-7whai7nr | Could the appearance of this tumor be related either to transplanted pneumocytes or it is inmunosupression the main risk factor? |
| cord-000718-7whai7nr | Could these AIPs provide the way to escape the cell death? |
| cord-000718-7whai7nr | Is the contusion a cause of death per se? |
| cord-000718-7whai7nr | More than it meets the eye? |
| cord-000718-7whai7nr | OFP-03- 002 Tumor budding in pancreatic cancer: Are we missing important prognostic information? |
| cord-000718-7whai7nr | OFP-09- 002 Is quality of histological and cytological slides a palatable issue?: |
| cord-000718-7whai7nr | Present study investigated; could nuclear morphometery differentiate histomorphologically similar paediatric malignant small round cell tumors in H& E stained sections for using in a poor resource country? |
| cord-000718-7whai7nr | Telomerase expression in urothelial carcinomas of the urinary bladder: Does it make sense for carcinogenesis or prognosis? |
| cord-000718-7whai7nr | Turkey Objective: Is there an effect of the length of appendix vermiformis on the settlement of the bowel parasites? |
| cord-000718-7whai7nr | Which is the best method to measure multiple breast cancer? |
| cord-000718-7whai7nr | Which morphological criteria ensure the diagnosis? |
| cord-000718-7whai7nr | and CyclinD3 useful to characterize oncocytic adenomas and carcinomas? |
| cord-000718-7whai7nr | usual finding in gastrointestinal specimen? |
| cord-306798-f28264k3 | A balance between clinical expression and epidemiological silence Tissue and cellular tropism, pathology and pathogenesis of Ebola and Marburg viruses Clinical features and pathobiology of Ebolavirus infection Ebola virus disease in Africa: epidemiology and nosocomial transmission Are adaptive randomised trials or non- randomised studies the best way to address the Ebola outbreak in west Africa? |
| cord-306798-f28264k3 | How can blood operators best prepare for emerging threats? |
| cord-306798-f28264k3 | The Future of Pathogen Testing? |
| cord-306798-f28264k3 | The risk- based decision- making framework Risk- based decisionmaking for blood safety: preliminary report of a consensus conference How safe is safe enough, who decides and how? |
| cord-306798-f28264k3 | WHO commends Sierra Leone for stopping Ebola virus transmission What factors might have led to the emergence of Ebola in West Africa? |
| cord-306798-f28264k3 | Why do some emerging infections impact blood safety? |
| cord-306798-f28264k3 | Why is Ebola less deadly in America than in Africa? |
| cord-326785-le2t1l8g | Bronchial biopsies were taken from right upper and middle lobe carinas lmmunastaining was performed on acetone fixed cells and frozen tissue Sections using alkaline phosphatase and immunoperoxidase techniques All biopsies showed strong positive staining of epithelium for alphe? |
| cord-326785-le2t1l8g | Roberts? |
| cord-326785-le2t1l8g | There was striking plasma cell differentiation and COlonisation of lymphad folllcks by monacytoid cell?. |
| cord-326785-le2t1l8g | buta-2and~-4showednosignificantdifferencefromnormal Thelncreasedlntegrin expression by keratinocytes seems to be a reflection of awered epidermal differentiation rather than increased keratinoc? |
| cord-326785-le2t1l8g | may h e up to 1001oid duriLg?& erehkpoxic; tress. |
| cord-347221-g98q9cga | Front Immunol Immune response in severe infection: could life- saving drugs be potentially harmful? |
| cord-347221-g98q9cga | Hype or Hope? 2020: |
| cord-347221-g98q9cga | J o u r n a l P r e-p r o o f Epidemiologic clues to SARS origin in China Surveillance of influenza pandemic( H1N1) 2009 in Spain Middle East respiratory syndrome coronavirus: epidemic potential or a storm in a teacup? |
| cord-348860-zaimorg0 | Kaposi's sarcoma- associated herpesvirus: a new DNA tumor virus A genomic perspective on protein families Microarrays under the microscope Microarray techniques in pathology: tool or toy? |
| cord-348860-zaimorg0 | Many experimental studies have gone into establishing the different cellular pathways modulated by the virus, and whether a common theme exists for all viruses or each virus behaves differently? |
| cord-339152-wfakzb6w | : where are we? |
| cord-339152-wfakzb6w | COVID-19 Trained innate immunity not always amicable Scores of coronavirus vaccines are in competition-how will scientists choose the best? |
| cord-339152-wfakzb6w | Covid-19: what do we know so far about a vaccine? |
| cord-339152-wfakzb6w | How severe and prevalent are Ebola and Marburg viruses? |
| cord-298136-mel9fxw8 | ( Office for Official Publications of the European Communities Re- examining the role of patents in appropriating the value of DNA sequences Bioinformatics-a patenting view Are you ready for the revolution? |
| cord-298136-mel9fxw8 | Are any special uses attributed to genomes that are not attributed to isolated fragments of DNA? |
| cord-298136-mel9fxw8 | But what is the difference between wholegenome patents and patents that have been issued on whole microorganisms? |
| cord-298136-mel9fxw8 | Evidence and Policies SARS genome patent: symptom or disease? |
| cord-298136-mel9fxw8 | Is the genome just a concept that is used to unite several nucleotide sequences into a single invention, or is it a causally efficacious phenomenon that does something more than an aggregation of genes can do? |
| cord-298136-mel9fxw8 | Is the genome just … used to unite several nucleotide sequences into a single invention, or … a causally efficacious phenomenon that does something more than an aggregation of genes can do?" |
| cord-298136-mel9fxw8 | Is the genome sequence the representative of the organism? |
| cord-298136-mel9fxw8 | The minimal gene complement of Mycoplasma genitalium Whole- genome random sequencing and assembly of Haemophilus influenzae Rd Complete genome sequence of the methanogenic archaeon, Methanococcus jannaschii Can patents deter innovation? |
| cord-298136-mel9fxw8 | What is the relationship between the utility of a part( a gene) and any utility associated with the whole( the genome)? |
| cord-342819-p8wp6yvo | 33 Need for adjuvants? |
| cord-342819-p8wp6yvo | A potential solution for emerging pathogens and biodefense? |
| cord-342819-p8wp6yvo | How many epitopes? |
| cord-342819-p8wp6yvo | What happened and what lessons can we learn? |
| cord-336749-qbko22vf | A new role for PAR: a label for subsequent ubiquitylation- mediated proteosomal degradation? |
| cord-336749-qbko22vf | How do macrodomains recognize PAR? |
| cord-336749-qbko22vf | However, in light of what has been discussed throughout this review, the major open question is: why is there a need for( at least) four different PARbinding modules? |
| cord-336749-qbko22vf | One final question is, what is the role of PARG in PARylation- coupled, ubiquitylation- mediated protein degradation, such as in the DNA damage response? |
| cord-336749-qbko22vf | This also raises the question of how can so many proteins endowed with PAR- binding domains and capable of binding free PAR, at least in vitro, discriminate between their PARylated protein targets( or even free PAR) in vivo? |
| cord-342737-hhs3owvr | First, can the presence of HBoV1 in the NPA represent only passive, nonreplicating mucosal contamination from a family member? |
| cord-342737-hhs3owvr | Last, does immunity to HBoV2 or HBoV3 cross- protect against HBoV1 and vice versa? |
| cord-342737-hhs3owvr | Second, can HBoV1 establish true latency, and if so, can other respiratory viruses reactivate the virus? |
| cord-342737-hhs3owvr | Third, how often does HBoV1 cause symptomatic reinfections? |
| cord-268122-74nj66vb | Are there any tissue specificities for NAD+ boosting, such tissue preferences of distinct NAD+ precursors? |
| cord-268122-74nj66vb | Delivering widespread BRCA testing and PARP inhibition to patients with ovarian cancer Synthetic lethal therapies for cancer: what's next after PARP inhibitors? |
| cord-268122-74nj66vb | Enhanced SIRT6 activity abrogates the neurotoxic phenotype of astrocytes expressing ALS- linked mutant SOD1 Region- specific changes in the immunoreactivity of SIRT1 expression in the central nervous system of SOD1(G93A) transgenic mice as an in vivo model of amyotrophic lateral sclerosis SIRT1 deacetylase in aging- induced neuromuscular degeneration and amyotrophic lateral sclerosis SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/ HSP70i chaperone system Differential sirtuin expression patterns in amyotrophic lateral sclerosis( ALS) postmortem tissue: neuroprotective or neurotoxic properties of sirtuins in ALS? |
| cord-268122-74nj66vb | Free Rad Efficacy and tolerability of EH301 for amyotrophic lateral sclerosis: a randomized, double- blind, placebo- controlled human pilot study Dietary metabolism, the gut microbiome, and heart failure Epidemiology and aetiology of heart failure Raising NAD in heart failure: time to translate? |
| cord-268122-74nj66vb | How, when, and where do human β- cells regenerate? |
| cord-268122-74nj66vb | NAD+/NADH balance regulate breast cancer progression Regulation of cancer cell metabolism Metastasis and oxidative stress: are antioxidants a metabolic driver of progression? |
| cord-268122-74nj66vb | SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis Could sirtuin activities modify ALS onset and progression? |
| cord-268122-74nj66vb | What is the crosstalk with the NAD+ systems of each organ? |
| cord-268122-74nj66vb | What is the distinct NAD+ metabolome in each tissue? |
| cord-268122-74nj66vb | Why do viruses cause cancer? |
| cord-268122-74nj66vb | a novel target for modulating NAD(+) homeostasis Is the enzyme ACMSD a novel therapeutic target in Parkinson's disease? |
| cord-268122-74nj66vb | how is alcohol metabolized by the body? |
| cord-268122-74nj66vb | signaling pathway Non- alcoholic fatty liver disease as a cause and a consequence of metabolic syndrome Nicotinamide and NAFLD: is there nothing new under the Sun? |
| cord-289535-srrfr1es | CD8+ T- cell responses after rAd5 boost in a randomized clinical trial BCG- induced trained immunity: can it offer protection against COVID-19? |
| cord-289535-srrfr1es | Can existing live vaccines prevent COVID-19? |
| cord-289535-srrfr1es | Could an unrelated live attenuated vaccine serve as a preventive measure to dampen septic inflammation associated with COVID-19 infection? |
| cord-289535-srrfr1es | How immune T- cell augmentation can help prevent COVID-19: a possible nutritional solution using ketogenic lifestyle jri/ vol4without altering disease transmission work? |
| cord-289535-srrfr1es | How to achieve equitable global distribution? |
| cord-289535-srrfr1es | Is human challenge part of the pathway to a licensed product? |
| cord-289535-srrfr1es | Is there an ideal animal model for SARS? |
| cord-289535-srrfr1es | Mammalian microRNAs predominantly act to decrease target mRNA levels AU- rich elements and associated factors: are there unifying principles? |
| cord-289535-srrfr1es | Nonspecific protection of mice against influenza virus infection by local or systemic immunization with bacille Calmette- Guerin Is global BCG vaccination coverage relevant to the progression of SARS- CoV-2 pandemic? |
| cord-289535-srrfr1es | What is the risk of immunopathology? |
| cord-289535-srrfr1es | Why Norwood? |
| cord-320005-i30t7cvr | How can we define the limits between what is permitted and what is prohibited, or between privacy and responsibility towards third parties? |
| cord-320005-i30t7cvr | How will it influence medicine? |
| cord-320005-i30t7cvr | If only 1% to 2% of the bases in the human genome code for proteins, then what do the rest do? |
| cord-320005-i30t7cvr | What ethical problems does it pose? |
| cord-320005-i30t7cvr | What general lessons has it taught us so far? |
| cord-320005-i30t7cvr | What was the genesis of this project? |
| cord-320005-i30t7cvr | Why are there so many repetitive sequences in the human genome not found in the genomes of invertebrates? |
| cord-320005-i30t7cvr | has it given rise to? |
| cord-347710-ff64y6ef | : where do we stand? |
| cord-347710-ff64y6ef | Hsp90 inhibitors: a potential treatment for latent EBV infection? |
| cord-347710-ff64y6ef | The hepatitis E virus open reading frame 3 product interacts with microtubules and interferes with their dynamics The ins and outs of tubulin acetylation: more than just a post- translational modification? |
| cord-347710-ff64y6ef | diagnostic, prognostic, predictive, and treatment implications Altered states: selectively drugging the Hsp90 cancer chaperone Heat shock proteins promote cancer: it's a protection racket Heat shock proteins and cancer: intracellular chaperones or extracellular signalling ligands? |
| cord-281188-0cql96hu | A numbers game: ribosome densities, bacterial growth, and antibiotic- mediated stasis and death Cause and effect in biology Cause and effect in biology revisited: is Mayr's proximate- ultimate dichotomy still useful? |
| cord-281188-0cql96hu | But is it worth the effort? |
| cord-281188-0cql96hu | Could high- concentration rifampicin kill rifampicin- resistant M. tuberculosis? |
| cord-281188-0cql96hu | For example, why do some ribosome- targeting drugs, such as most but not all aminoglycosides, rapidly kill bacteria, whereas others, such as the macrolides, prevent replication and kill at low rates if at all? |
| cord-281188-0cql96hu | How antibiotics kill bacteria: new models needed? |
| cord-281188-0cql96hu | Is there a unique mechanism by which antibiotics prevent the replication of bacteria? |
| cord-281188-0cql96hu | Is this information, which is critical to the clinical applications of these drugs, not entirely sufficient? |
| cord-281188-0cql96hu | The rate of killing of Escherichia coli by beta- lactam antibiotics is strictly proportional to the rate of bacterial growth Kinetics of antimicrobial activity Mechanisms of antimicrobial action of antiseptics and disinfectants: an increasingly important area of investigation Bacterial target sites for biocide action Antibiotic combinations: should they be tested? |
| cord-281188-0cql96hu | What are the causes of death? |
| cord-281188-0cql96hu | What does the relationship between the concentration of antibiotics and the rate of growth and death of bacteria( that is, pharmacodynamics) tell us about how antibiotics do their bacteriostatic and bactericidal actions? |
| cord-281188-0cql96hu | When is a bacterium dead? |
| cord-281188-0cql96hu | When, how and why? |
| cord-281188-0cql96hu | Why is inhibition of protein synthesis lethal in some cases and only static in others? |
| cord-281188-0cql96hu | Why is the loss of cell wall integrity and lysis the result of reduced peptidoglycan biogenesis? |
| cord-315616-pvt0amth | 2P P- O- Methylation in the RNA world? |
| cord-315616-pvt0amth | A methyl- RNA genome? |
| cord-315616-pvt0amth | Although ribonucleotide reduction is a crucial link in the transition from RNA to DNA, is this single step suf¢cient? |
| cord-315616-pvt0amth | Can 2P P- O- methylation be carried out by a ribozyme? |
| cord-315616-pvt0amth | How can the model be tested? |
| cord-315616-pvt0amth | If 2P- O- methyl RNA is a candidate intermediate between RNA and DNA, what selection was there to go from methyl- RNA to DNA? |
| cord-315616-pvt0amth | Pyrococcus furiosus: a critical enzyme in the evolution of DNA genomes? |
| cord-315616-pvt0amth | Where is there suf¢cient space to encode simple proteins, then more complex catalytic proteins capable of generating and controlling protein radicals? |
| cord-315616-pvt0amth | title: Methyl- RNA: an evolutionary bridge between RNA and DNA? |
| cord-022476-g826uiqx | A clinical and pathologic study of chronic sinusitis: the role of the eosinophil Eosinophils in nasal polyps and nasal mucosa: an immunohistochemical study Toxicity of eosinophil cationic proteins for guinea pig tracheal epithelium in vitro Chronic sinusitis: risk factors for extensive disease Allergic aspergillosis of the maxillary sinuses Allergic fungal sinusitis: allergic, infectious, or both? |
| cord-022476-g826uiqx | Are Eosinophils Contributing to the Pathophysiology? |
| cord-022476-g826uiqx | But how are DNA traps formed? |
| cord-022476-g826uiqx | Can they be used as biomarkers of eosinophil activation? |
| cord-022476-g826uiqx | Do they prevent exaggerated eosinophil- mediated tissue pathology? |
| cord-022476-g826uiqx | For example: are eosinophils protective against fungal colonization or infection in humans? |
| cord-022476-g826uiqx | For instance: l Do eosinophils play a role in the fight against pathogens in asthma and other allergic diseases? |
| cord-022476-g826uiqx | How do DNA traps correlate with other markers of inflammation? |
| cord-022476-g826uiqx | How do eosinophils recognize and respond to fungal products within the Alternaria extracts? |
| cord-022476-g826uiqx | How do human eosinophils become activated in diseased tissues or at the site of the immune response, resulting in tissue damage? |
| cord-022476-g826uiqx | In SAFS or CRS, do antifungal immune responses and the aberrant activation of eosinophils play major roles in disease pathophysiology? |
| cord-022476-g826uiqx | The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo: a novel'alarmin'? |
| cord-022476-g826uiqx | The burden of respiratory syncytial virus infection in young children RSV 2007: recent advances in respiratory syncytial virus research Human genetic factors and respiratory syncytial virus disease severity High affinity IgE receptor on eosinophils is involved in defence against parasites Allergen- induced recruitment of FcεRIþ eosinophils in human atopic skin Increased expression of high affinity IgE( Fcep- silonRI) receptor- alpha chain mRNA and protein- bearing eosinophils in human allergen- induced atopic asthma Does IgE bind to and activate eosinophils from patients with allergy? |
| cord-022476-g826uiqx | The diagnosis and incidence of allergic fungal sinusitis Eosinophilic fungal rhinosinusitis': a common disorder in Europe? |
| cord-022476-g826uiqx | The link between fungi and severe asthma: a summary of the evidence Asthma cases attributable to atopy: results from the Third National Health and Nutrition Examination Survey Are atopy and specific IgE to mites and molds important for adult asthma? |
| cord-022476-g826uiqx | Thus, a fundamental and important question still remains: what triggers eosinophil activation and proinflammatory mediator release in human disease? |
| cord-022476-g826uiqx | Two highly homologous ribonuclease genes expressed in mouse eosinophils identify a larger subgroup of the mammalian ribonuclease superfamily Eosinophil degranulation: an evolutionary vestige or a universally destructive effector function? |
| cord-022476-g826uiqx | Under which conditions do eosinophil cationic proteins exhibit antimicrobial properties? |
| cord-022476-g826uiqx | Which molecules in fungi and host receptors play a pivotal role in antifungal immune responses? |
| cord-022476-g826uiqx | how long do DNA traps remain in tissues? |
| cord-014794-yppi30a0 | Are MUC 2 and MUC 5AC reliable markers in the differential diagnosis of primary and metastatic ovarian carcinomas? |
| cord-014794-yppi30a0 | Are there any relationship between Bellini duct carcinoma and urothelial cell carcinoma? |
| cord-014794-yppi30a0 | Can a pleomorphic vulvar leiomyoma be a tumor with local aggressive behavior? |
| cord-014794-yppi30a0 | Case report The full- term female patient-3100 g/49 cm-has been developing well with the exception of early( intrauterine?) |
| cord-014794-yppi30a0 | Chromophobe renal cell carcinoma: the variant with the best outcome? |
| cord-014794-yppi30a0 | Do human papillomaviruses infect proximal parts of the male genital tract? |
| cord-014794-yppi30a0 | Does HPV play a role in the development of bladder TCC? |
| cord-014794-yppi30a0 | Does TGF- α1 prevent carcinoma spreading? |
| cord-014794-yppi30a0 | Ezrin immunoreactivity: Is it a usefull marker for the prognosis and grading of astrocytoma? |
| cord-014794-yppi30a0 | Is telomerase catalytic subunit gene re- expression an early event in gallbladder carcinogenesis? |
| cord-014794-yppi30a0 | Is the activation of Akt a prognostic parameter in colorectal cancer? |
| cord-014794-yppi30a0 | Is there any prognostic significance for HER2 protein in urothelial tumors of the upper urinary tract? |
| cord-014794-yppi30a0 | It has been speculated that secondary iron overload( heavy alcohol, chronic hepatitis,?-thalassemia) may be a critical co- factor in those heterozygotes that develop symptoms of HH. |
| cord-014794-yppi30a0 | Measurements of DNA amount and nuclear size by image cytometry: are these two features sufficient for diagnosis of early lung cancer? |
| cord-014794-yppi30a0 | Primary or metastatic? |
| cord-014794-yppi30a0 | Trichoblastic fibroma or primary soft tissue adamantinoma? |
| cord-014794-yppi30a0 | Two questions are to be studied: 1. does FH, HP, Adenoma( A) and Carcinoma( Ca) represent a continuum in terms of Ki-67 proliferative activity? |
| cord-014794-yppi30a0 | What is the relation of age, gender and histological types to the subsite location of colon carcinoma? |
| cord-014794-yppi30a0 | carcinoma( HP- Ca)? |
| cord-014794-yppi30a0 | it possible to predict clinical behaviour? |
| cord-304424-048xo7jn | A novel paramyxovirus? |
| cord-304424-048xo7jn | And what exactly did the host look like then? |
| cord-304424-048xo7jn | Are we missing half of the viruses in the ocean? |
| cord-304424-048xo7jn | At what point in host evolution does an RNA viral pathogen arrive? |
| cord-304424-048xo7jn | CRISPR- Cas9 Species- level deconvolution of metagenome assemblies with Hi- C- based contact probability maps Virus discovery: are we scientists or genome collectors? |
| cord-304424-048xo7jn | Metagenomics for the discovery of novel human viruses Global epidemiology of noninfluenza RNA respiratory viruses: data gaps and a growing need for surveillance Viral metagenomics on animals as a tool for the detection of zoonoses prior to human infection? |
| cord-304424-048xo7jn | Other than sampling more broadly and maintaining the exponential growth in Genbank, what are orthogonal challenges for future RNA virus metagenomic studies? |
| cord-304424-048xo7jn | Tombusviridae and Nodaviridae? |
| cord-304424-048xo7jn | What do you get when you cross a picornavirus and a calicivirus? |
| cord-304424-048xo7jn | Where do we begin with RNA virus metagenomics? |
| cord-304424-048xo7jn | Why has RNA virus metagenomics been so successful? |
| cord-021966-5m21bsrw | > Having chosen an antigen and presentation system, what is the best way to produce it on a large scale? |
| cord-021966-5m21bsrw | A review of the Vaccine Adverse Event Reporting System database Vaccine safety surveillance using large linked databases: opportunities, hazards and proposed guidelines Permanent brain damage and pertussis vaccination: is the end of the saga in sight? |
| cord-021966-5m21bsrw | Can a specific antigen( or antigens) be identified that represents the target of protective host immune responses? |
| cord-021966-5m21bsrw | Can the pathogen be grown in culture? |
| cord-021966-5m21bsrw | Even larger phase IIb studies can provide additional data on vaccine safety and immunogenicity in subjects generally representative of those for whom the vaccine might be recommended, but importantly, also provide the first opportunity to address to answer the question,'Does this vaccine work in humans?' |
| cord-021966-5m21bsrw | If natural immunity capable of preventing re- infection follows an initial infection with the pathogen, can a specific host immune effector mechanism( e.g., antibody, CD8 T- cell) be identified as the likely agent( or'correlate') of immune protection? |
| cord-021966-5m21bsrw | If so, can a threshold level of this specific immune correlate needed for protection from re- infection be defined? |
| cord-021966-5m21bsrw | If so, does the pathogen cause such a life- threatening disease that an attenuated version of the virus would face an impossible barrier for demonstration of safety? |
| cord-021966-5m21bsrw | If the infection occurs relatively rarely in an overall population, can a subset of the population be identified that has a higher risk of infection so as to accelerate the achievement of statistically significant protection? |
| cord-021966-5m21bsrw | If the protective immune response is mediated by antibodies, can the target antigen( be it a protein or polysaccharide) be produced in scalable quantities in a form that mimics its native structure so that it can effectively elicit antibody responses that can block the key functional role(s) of the target molecule in the pathogen lifecycle or otherwise lead to the clearance of an incipient pathogen infection? |
| cord-021966-5m21bsrw | Is immunity to a given antigen associated with protection against disease following re- exposure in the context of natural infection? |
| cord-021966-5m21bsrw | Is the antigen of interest sufficiently immunogenic on its own, or is augmentation of the desired immune response by conjugation to a specific carrier or addition of an adjuvant necessary to elicit a sufficient and sufficiently durable immune response in individuals in the target population for vaccination? |
| cord-021966-5m21bsrw | Is this subset sufficiently similar to the rest of the population to enable extrapolation of the clinical results to the broader target population as a whole? |
| cord-021966-5m21bsrw | Recent advances in the development of HIV-1 vaccines using replication- incompetent adenovirus vectors One step forward, two steps back-will there ever be an AIDS vaccine? |
| cord-021966-5m21bsrw | The MMR vaccination and autism controversy in United Kingdom 1998- 2005: inevitable community outrage or a failure of risk communication? |
| cord-021966-5m21bsrw | What are the major unmet medical and public health needs today? |
| cord-021966-5m21bsrw | What is known about the natural history and pathogenic mechanisms of the infection of interest? |
| cord-021966-5m21bsrw | What is the attack rate of the infection in the general population? |
| cord-021966-5m21bsrw | What is the most effective way to present the antigens of the pathogen of interest to the immune system? |
| cord-021966-5m21bsrw | What tests to evaluate vaccine immunogenicity will need to carried out on clinical samples obtained from participants in the clinical trials? |
| cord-021966-5m21bsrw | What types of potential safety concerns can be anticipated for the vaccine in question? |
| cord-021966-5m21bsrw | Will measurement of antibody titers, T- cell responses, pathogen presence and quantity, pathogen serotype, and any other parameter peculiar to the disease in question represent the primary criteria for vaccine effect? |
| cord-015368-a0qz4tb9 | 009 State- of- the- art 2007: mitral valve repairminimally invasive or median sternotomy? |
| cord-015368-a0qz4tb9 | 115 Prophylactic operations in palliativ surgerya conflict? |
| cord-015368-a0qz4tb9 | 201 Is TME an adequate treatment for low rectal cancer? |
| cord-015368-a0qz4tb9 | 229 Teaching means learning-who benefits from academic teaching duties? |
| cord-015368-a0qz4tb9 | 233 Single- port appendectomy in obese children-a useful alternative? |
| cord-015368-a0qz4tb9 | 253 Does lifting of the abdominal wall for the set up of the pneumoperitoneum for laparoscopy increase the safetiness? |
| cord-015368-a0qz4tb9 | 333 Breast cancer centres-can quality only be achieved in high- volume- institutions? |
| cord-015368-a0qz4tb9 | 354 Fast track surgery without thoracic peridural anaesthesia? |
| cord-015368-a0qz4tb9 | 368 Segmental duodenectomy at periampullary lesions-an adequate therapy? |
| cord-015368-a0qz4tb9 | 380 Oversewing of gastric pull up staple line in reconstruction after esophageal resection: counterproductive or helpful procedure? |
| cord-015368-a0qz4tb9 | A protective effect towards myocyte damage was further underlined by reduced troponin levels in groups receiving B- beta 15- 42. 081 Acute cellular rejection after cardiac transplantation-is there a way to reduce the number of biopsies? |
| cord-015368-a0qz4tb9 | Based on our case we like to discuss the indication for surgery, incidence of malignant change, risk factors, discovery and diagnosis, detection and prevention, the surgical procedures for the treatment of chledochal cysts and especially whether the typ of surgery have an impact on malignant transformation? |
| cord-015368-a0qz4tb9 | But how can the terms''malpractice''or medical error be defined at all? |
| cord-015368-a0qz4tb9 | But what is the standard treatment in recurrent pneumothorax after primary operation in the era of VATS? |
| cord-015368-a0qz4tb9 | Does the lunar phase influence the incidence of postoperative haemorrhage after thyroid surgery? |
| cord-015368-a0qz4tb9 | Does the route of gastric pull- up influence the oxygen supply of the anastomosis? |
| cord-015368-a0qz4tb9 | However, the question remains, which fields of specialisation are realistic for a general surgical department with a limited staff? |
| cord-015368-a0qz4tb9 | Is the laparoscopic sigmoid resection with a primary anastomosis in acute sigmoid diverticulitis the optimal surgical therapy? |
| cord-015368-a0qz4tb9 | P08 Stamm- Kader gastrostomy or PEG W. H. Weissenhofer Time- honoured or forgotten? |
| cord-015368-a0qz4tb9 | P21 Lymphatic vessel invasion in upper GI cancer: an indication for an additive or adjuvant therapy? |
| cord-015368-a0qz4tb9 | P33 Lipocalin-2, regulator or byproduct during ischemia and reperfusion? |
| cord-015368-a0qz4tb9 | Pure esophageal atresia with normal outer appearance-a new subtype? |
| cord-015368-a0qz4tb9 | Stenosis and occlusion of the proximal subclavian artery-surgical or interventional treatment? |
| cord-015368-a0qz4tb9 | Which conditions must be fulfilled for the motion to court or the medical arbitration committee? |
| cord-321697-yua3apfi | : cord-321697-yua3apfi authors: Crigna, Adriana Torres; Samec, Marek; Koklesova, Lenka; Liskova, Alena; Giordano, Frank A.; Kubatka, Peter; Golubnitschaja, Olga title: Cell- free nucleic acid patterns in disease prediction and monitoring — hype or hope? |
| cord-321697-yua3apfi | Alu repeat sequences are present in increased proportions compared to a unique gene in plasma/ serum DNA: evidence for a preferential release from viable cells? |
| cord-321697-yua3apfi | Cham: Advances in Predictive, Preventive and Personalised Medicine Mitochondrial dysfunction in the aging retina Parkinson disease epidemiology, pathology, genetics, and pathophysiology Mitochondria and autophagy dysfunction in glucocorticoidinduced ocular hypertension/ glaucoma mice model Cancer predisposition in diabetics: risk factors considered for predictive diagnostics and targeted preventive measures Cell cycle checkpoints: the role and evaluation for early diagnosis of senescence, cardiovascular, cancer, and neurodegenerative diseases Feeling cold and other underestimated symptoms in breast cancer: anecdotes or individual profiles for advanced patient stratification? |
| cord-321697-yua3apfi | Consequently, the question is- how to distinguish between beneficial physical activity on one hand and damaging exercise- induced oxidative stress on the other hand, when providing recommendations at individual level? |
| cord-321697-yua3apfi | From Phenotype to Associated Pathologies, Prediction, Prevention and Personalisation Flammer syndrome Risks associated with the stroke predisposition at young age: facts and hypotheses in light of individualized predictive and preventive approach Pre- metastatic niches"in breast cancer: are they created by or prior to the tumour onset Mystery of the brain metastatic disease in breast cancer patients: improved patient stratification, disease prediction and targeted prevention on the horizon? |
| cord-321697-yua3apfi | MicroRNAs in human diseases: from cancer to cardiovascular disease MicroRNA function in cancer: oncogene or a tumor suppressor? |
| cord-321697-yua3apfi | More answers or More confusion? MicroRNA |
| cord-321697-yua3apfi | What is known about CFNAs signature utility in COVID-19 management? |
| cord-321697-yua3apfi | Why the gold standard approach by mammography demands extension by multiomics? |
| cord-321697-yua3apfi | effective and affordable cancer care hsa- miR-135a-1 inhibits prostate cancer cell growth and migration by targeting EGFR Covid-19 pandemic by the"realtime"monitoring: the Tunisian case and lessons for global epidemics in the context of 3PM strategies COVID-19 what have we learned? |
| cord-321697-yua3apfi | primary and recurrent colorectal cancer Establishment of tumor- specific copy number alterations from plasma DNA of patients with cancer Is the role of circulating DNA as a biomarker of cancer being prematurely overrated? |
| cord-303265-v6ci69n0 | An optimal degree of physical and chemical heterogeneity for the origin of life? |
| cord-303265-v6ci69n0 | Did they originate before or after a cellular world was in place? |
| cord-303265-v6ci69n0 | Do viruses exist essentially as selfish parasites, or have they played constructive roles in the biosphere? |
| cord-303265-v6ci69n0 | Does virus variation play a role in the unfolding of viral disease processes? |
| cord-303265-v6ci69n0 | Have viruses been maintained as modulators of the population numbers of their host species? |
| cord-303265-v6ci69n0 | How did replicating and coding RNAs first get together? |
| cord-303265-v6ci69n0 | Is cyanoacetylene prebiotic? |
| cord-303265-v6ci69n0 | Is it quasispecies dynamics that characterize RNA and many DNA viruses, a remnant of an adaptive strategy that presided all life forms in the remote past? |
| cord-303265-v6ci69n0 | Is the behavior of present- day viruses at the population level only an inheritance of their origins or a present- day necessity? |
| cord-303265-v6ci69n0 | Or have they? |
| cord-303265-v6ci69n0 | Origin of hepatitis delta virus Bacteriophages and pathogenicity: more than just providing a toxin? |
| cord-303265-v6ci69n0 | What is the origin of viruses? |
| cord-303265-v6ci69n0 | What selective forces have maintained multiple viruses as parasites of unicellular and multicellular organisms? |
| cord-303265-v6ci69n0 | What selective forces might have led to the integration of these features? |
| cord-303265-v6ci69n0 | Why have a few viral forms not outcompeted most other forms? |
| cord-303265-v6ci69n0 | Why should we feel disappointed by our inability to even foresee the possible answers to these luring questions? |
| cord-280691-nzc8ir0n | : The war to seize the genes Shiji Zhi Zhang: Jiyin Qian Duo Zhan[ war of the century: The war to seize the genes Asthma gene discovered Cultural boundaries of science: Credibility on the line Common genetic variation and human traits Just one child: Science and policy in Deng's China Gene war of the century? |
| cord-280691-nzc8ir0n | As war is invariably a continuation of politics by other means, what was the politics behind it? |
| cord-280691-nzc8ir0n | But what is it? |
| cord-280691-nzc8ir0n | Did these precious genetic resources actually exist? |
| cord-280691-nzc8ir0n | How Harvard University exploited rural Chinese villagers for their DNA Appellate Court weighs'obvious'patents Genetic risk prediction- are we there yet? |
| cord-280691-nzc8ir0n | How did this''war''end? |
| cord-280691-nzc8ir0n | If a person strikes a deal with a drug company, or acts simply out of genuine altruism, and is willing to give away his blood sample, does the state have the right to intervene? |
| cord-280691-nzc8ir0n | If so, would such intervention infringe on the donor's human rights? |
| cord-280691-nzc8ir0n | If the state does have the right to intervene, where can we draw the line? |
| cord-280691-nzc8ir0n | The Harvard case of Xu Xiping: Exploitation of the people, scientific advance, or genetic theft? |
| cord-280691-nzc8ir0n | What constitutes a genetic resource, then? |
| cord-280691-nzc8ir0n | What constitutes a genetic resource? |
| cord-280691-nzc8ir0n | What happened after the conflict? |
| cord-280691-nzc8ir0n | What happened to the people who were embroiled in the''war''? |
| cord-280691-nzc8ir0n | What was at stake? |
| cord-280691-nzc8ir0n | Who was the most likely beneficiary of the gene- hunting endeavor? |
| cord-280691-nzc8ir0n | Who were the winners and losers, if there were any in the first place? |
| cord-346853-0c1qdjb5 | Although the focus on changing human ecology and phylogenetic history was an important and necessary first step, and it will often be impossible to disentangle ecology and genetics when explaining the emergence of a specific pathogen, it is also essential to ask what evolutionary processes are responsible for the appearance and spread of pathogens? |
| cord-346853-0c1qdjb5 | Are certain types of virus more likely to emerge than others? |
| cord-346853-0c1qdjb5 | Are viruses from phylogenetically related host species more likely to undergo cross- species transmission than those viruses from distantly related host species? |
| cord-346853-0c1qdjb5 | Does viral emergence require adaptation to the new host species? |
| cord-346853-0c1qdjb5 | Is recombination a prerequisite for viral emergence? |
| cord-346853-0c1qdjb5 | Perhaps the central question in this respect is whether, following cross- species transmission, emergent viruses must adapt to replicate in their new species, or whether the process of emergence is essentially blind to natural selection? |
| cord-346853-0c1qdjb5 | Specifically, are those viruses from our closest relatives, the simian primates, more able to infect us than those from other mammalian orders? |
| cord-346853-0c1qdjb5 | The key question, therefore, is whether these mutations appear de novo in humans, in the short transmission networks of people who initially suffer avian influenza, or whether they preexist in the avian population, and if the appropriate strain is transmitted, then will emergence follow? |
| cord-346853-0c1qdjb5 | Why might this be so? |
| cord-009664-kb9fnbgy | ( Symposium arranged with EFWISG) S460 MRSA in food products: cause for concern or case for complacency? |
| cord-009664-kb9fnbgy | And are we gaining or losing? |
| cord-009664-kb9fnbgy | And the equally valid question: to what extent does biological science benefit from study of fungi that are opportunistic pathogens? |
| cord-009664-kb9fnbgy | Are we aware? |
| cord-009664-kb9fnbgy | Are we in command? |
| cord-009664-kb9fnbgy | Clinical microbiology − is outsourcing the way to go? |
| cord-009664-kb9fnbgy | Do the efflux pump inhibitors reserpine and verapamil reduce the mutation frequency? |
| cord-009664-kb9fnbgy | Do we have a choice? |
| cord-009664-kb9fnbgy | Do we know where we are going? |
| cord-009664-kb9fnbgy | Do we recognise a driving force other than money? |
| cord-009664-kb9fnbgy | Does efflux phenotype impose a fitness cost? |
| cord-009664-kb9fnbgy | Emerging infections: can we cope with them? |
| cord-009664-kb9fnbgy | Furthermore, is there a pathophysiological impact of viral replication in individuals with CIHHV-6? |
| cord-009664-kb9fnbgy | If you do n't look for them, you wo n't find them: anaerobes revisited S481 Anaerobic microbiota of the mouth − friend or foe? |
| cord-009664-kb9fnbgy | Is it good, bad or just plain necessary? |
| cord-009664-kb9fnbgy | MRSA screening − will we ever agree? |
| cord-009664-kb9fnbgy | O391 Throwing caution to the winds? |
| cord-009664-kb9fnbgy | PBP 3 − SOS response? |
| cord-009664-kb9fnbgy | Patient management: the era of rapid diagnostic results( Symposium organised by Cepheid) S161 Will community MRSA and Clostridium difficile change infection control in hospitals? |
| cord-009664-kb9fnbgy | S485 Is culture still the gold standard, really? |
| cord-009664-kb9fnbgy | Should we oppose or cooperate? |
| cord-009664-kb9fnbgy | So, it is unclear how the transcription and translation of viral genes is influenced? |
| cord-009664-kb9fnbgy | The( r)evolution of clinical microbiology in Europe − is it good or bad? |
| cord-009664-kb9fnbgy | To what extent do patients benefit from translation of basic research into tools for clinical management? |
| cord-009664-kb9fnbgy | What about Europe? |
| cord-009664-kb9fnbgy | What is driving the evolution? |
| cord-009664-kb9fnbgy | or gyrA QRDR mutation frequencies than efflux negative isolates? |
| cord-009664-kb9fnbgy | which antifungal treatment for which patient? |
| cord-341029-49360l2a | : Inferences on protein evolution Are viruses a source of new protein folds for organisms? |
| cord-341029-49360l2a | Applying both comparative genomic and phylogenomic strategies, we asked a number of crucial questions: Can we quantify viral diversity? |
| cord-341029-49360l2a | Are viruses infecting different organisms evolutionarily related? |
| cord-341029-49360l2a | Are viruses monophyletic or polyphyletic? |
| cord-341029-49360l2a | Can we identify protein folds that define viral lineages based on common virion architectures? |
| cord-341029-49360l2a | Here, the more relevant question was asked: Do viruses infecting distantly related hosts share common protein folds? |
| cord-341029-49360l2a | How many unique protein folds exist in the virosphere? |
| cord-341029-49360l2a | The origins and ongoing evolution of viruses Viral proteins functioning in organelles: A cryptic origin? |
| cord-341029-49360l2a | What is the predominant direction of gene transfer( cell- to- virus or virus- to- cell)? |
| cord-341029-49360l2a | What were the earliest replicons? |
| cord-341029-49360l2a | Where do viruses lie on the tree of life? |
| cord-023364-ut56gczm | ( with a selfadministered questionnaire with an open- ended question: How does blood donation affect you? |
| cord-023364-ut56gczm | /socially during or after blood donation?) revealed that perceived negative effects( fatigue, diminished physical working capacity, vertigo/ dizziness, susceptibility to infections etc) |
| cord-023364-ut56gczm | : will it become reality? |
| cord-023364-ut56gczm | After the first 10 years with haemovigilance in the European countries, what has been the outcome of this big effort? |
| cord-023364-ut56gczm | Against this background where should our attentions focus? |
| cord-023364-ut56gczm | Aim: Does the interpretation of reports obtained through Outcome Review lead to an increase in the number of products per run and the overall productivity of the apheresis center? |
| cord-023364-ut56gczm | An ISO standard for blood transfusion? |
| cord-023364-ut56gczm | Are transfusion guidelines evidence- based? |
| cord-023364-ut56gczm | Being anti- D immunoglobulin a product that has the potential risk of infection transmission, is it appropriate to use indiscriminately as a routine antenatal prophylaxis? |
| cord-023364-ut56gczm | In addition, how much are we willing to pay for protection against emerging viruses? |
| cord-023364-ut56gczm | Is it a mutual decision making between physician and patient? |
| cord-023364-ut56gczm | Mobilization is also seen following the use of other cytokines( i.e. kit- L, Flt-3 L, IL-3) or chemokines( i.e. IL-8, Gro?), complement activation, etc., but the detailed mechanisms or the interdependence of these other pathways with the ones already proposed have not been worked out. |
| cord-023364-ut56gczm | Scientific evidence to fully answer the questions'when are platelet components clinically effective'and'what do we really know?'is limited. |
| cord-023364-ut56gczm | Should patients with thalassemia intermedia be regularly transfused? |
| cord-023364-ut56gczm | The research theme of this questionnaire is as follows:'What is the level of knowledge and of motivation in the non- remunerated and voluntary blood donation at students?' |
| cord-023364-ut56gczm | The subjects selected and debated were( i) what are the medical considerations for reducing the rate of mistransfusion? |
| cord-023364-ut56gczm | These ties to industry create a tension that actually is or can be perceived as • work internationally; • send young volunteers to international youth forums; • employ young people in your organisation; Why use volunteers in blood donor recruitment? |
| cord-023364-ut56gczm | We therefore resorted to developing our own model but ask the question: Why not have one international standard for blood transfusion? |
| cord-023364-ut56gczm | What is however the meaning of informed consent? |
| cord-023364-ut56gczm | Who cares about the quality of life of the chronic patients treated with blood products? |
| cord-023364-ut56gczm | Who will hear it? |
| cord-023364-ut56gczm | and( ii) what are the medical considerations for managing a limited blood inventory? |
| cord-023364-ut56gczm | to apply which screening method? |
| cord-023364-ut56gczm | your Trima ® can be? |
| cord-015394-uj7fe5y6 | : Do They Change during Pregnancy? |
| cord-015394-uj7fe5y6 | A Role for Intrahepatic GLUT1? |
| cord-015394-uj7fe5y6 | Androgens Influence Human Luteal Cells Function? |
| cord-015394-uj7fe5y6 | Are Contractions at 24- 32 weeks Gestation Less Painful Than Those at Full Term? |
| cord-015394-uj7fe5y6 | Could Confined Placental Mosaicism Account for Adverse Perinatal Outcomes in IVF Pregnancies? |
| cord-015394-uj7fe5y6 | Fact or Fiction? |
| cord-015394-uj7fe5y6 | Following Periconceptional Undernutrition or Twinning in Sheep? |
| cord-015394-uj7fe5y6 | In these experiments we sought to answer the question,'Does anandamide( AEA) work in the same manner as THC?' |
| cord-015394-uj7fe5y6 | Is There Evidence for Aromatase Activity in the Stroma of Postmenopausal Ovaries? |
| cord-015394-uj7fe5y6 | Is There a Role for Fatty Acids in the Pathogenesis of Pre- Eclampsia? |
| cord-015394-uj7fe5y6 | Is There a Seasonal Pattern in the Incidence of Post- Cesarean Endometritis? |
| cord-015394-uj7fe5y6 | Necessary? |
| cord-015394-uj7fe5y6 | Pregnancy Outcome? |
| cord-015394-uj7fe5y6 | Reason To Change Intrauterine Referral Practice in the Netherlands? |
| cord-015394-uj7fe5y6 | Term Preeclampsia: Any Risk for the Neonate? |
| cord-015394-uj7fe5y6 | and What Are the Roles Played by Peroxynitrite in Preeclamptic Women? |
| cord-324137-nau83mjv | , are the plasmids of other bacteria also devoid of G4s? |
| cord-324137-nau83mjv | Are the differences in the density and distribution of G4s in pathogens influenced by the ecological relationship they share with the host? |
| cord-324137-nau83mjv | Are the prokaryotic ORFs devoid of G4s to cut down on the energy cost of resolution of G4 for translation? |
| cord-324137-nau83mjv | As in D. radiodurans, are the unique adaptations of other extremophiles regulated by G4s? |
| cord-324137-nau83mjv | Do G4s represent structural elements for conservation of energy in bacterial metabolism? |
| cord-324137-nau83mjv | Do the pathogenicity islands in bacterial genomes have unique G4 profiles? |
| cord-324137-nau83mjv | Does the presence of G4s as an additional level of coordinated gene control in operons also signify the same? |
| cord-324137-nau83mjv | In other words, are there differences in the genomic densities of G4s among parasites, symbionts, commensals, and mutualists? |
| cord-324137-nau83mjv | Is G4-mediated control of gene expression exercised only in the early stages of central dogma to conserve energy? |
| cord-324137-nau83mjv | Microbiol G- quadruplexes in pathogens: a common route to virulence control? |
| cord-324137-nau83mjv | Stability and kinetics of G- quadruplex structures High- throughput sequencing of DNA G- quadruplex structures in the human genome How long is too long? |
| cord-324137-nau83mjv | Supplemental information associated with this article can be found Do G4-unwinding helicases encoded by the host interact with G4s in pathogens during infection? |
| cord-324137-nau83mjv | and the ability of G4s to pause replication, are they selectively eliminated from extrachromosomal elements to minimize interference, if any, in vertical transmission? |
| cord-324137-nau83mjv | mRNA translation Is the Epstein- Barr virus EBNA-1 protein an oncogen? |
| cord-324137-nau83mjv | such host- microbe interactions doubleedged swords that help the host to defend some infections and prove to be detrimental in others? |
| cord-317213-vhprfb1o | 13.1 pg/ ml Clinical/ real- world samples tested? |
| cord-317213-vhprfb1o | : what's new? |
| cord-317213-vhprfb1o | An electrochemical DNA hybridization detection assay based on a silver nanoparticle label HIV viral load monitoring in resource- limited regions: optional or necessary? |
| cord-317213-vhprfb1o | Cisplatin- tethered gold nanoparticles that exhibit enhanced reproducibility, drug loading, and stability: a step closer to pharmaceutical approval? |
| cord-317213-vhprfb1o | Clinical/ real- world samples tested? |
| cord-317213-vhprfb1o | Clinical/ real- world samples tested? |
| cord-317213-vhprfb1o | Clinical/ real- world samples tested? |
| cord-317213-vhprfb1o | Clinical/ real- world samples tested? |
| cord-317213-vhprfb1o | Clinical/ real- world samples tested? |
| cord-317213-vhprfb1o | Clinical/ real- world samples tested? |
| cord-317213-vhprfb1o | ECM: LOD of 260 pg/ ml Clinical/ real- world samples tested? |
| cord-317213-vhprfb1o | LOD slightly varied between antigen types, ranging from 0.8 ng/ ml for HBV to 1.5 ng/ ml for HCV and HEV • same upper limit of linear range( 350 ng/ ml) Clinical/ real- world samples tested? |
| cord-317213-vhprfb1o | no amplification or enrichment required Assay time: 20 min Clinical/ real- world samples tested? |
| cord-317213-vhprfb1o | • 100 viral particles in 100 μl samples Clinical/ real- world samples tested? |
| cord-317213-vhprfb1o | • amplification using PCR Detection range: 10 2-10 5 cells Clinical/ real- world samples tested? |
| cord-317213-vhprfb1o | • amplification using PCR • dilution with TE buffer solution, followed by denaturation in boiling water bath Detection range: • 1 fM-10 nM of nuc gene • 10- 10 6 CFU ml −1 for real- world samples Clinical/ real- world samples tested? |
| cord-023346-8sqbqjm1 | ( with a selfadministered questionnaire with an open- ended question: How does blood donation affect you? |
| cord-023346-8sqbqjm1 | /socially during or after blood donation?) revealed that perceived negative effects( fatigue, diminished physical working capacity, vertigo/ dizziness, susceptibility to infections etc) |
| cord-023346-8sqbqjm1 | : will it become reality? |
| cord-023346-8sqbqjm1 | After the first 10 years with haemovigilance in the European countries, what has been the outcome of this big effort? |
| cord-023346-8sqbqjm1 | Against this background where should our attentions focus? |
| cord-023346-8sqbqjm1 | Aim: Does the interpretation of reports obtained through Outcome Review lead to an increase in the number of products per run and the overall productivity of the apheresis center? |
| cord-023346-8sqbqjm1 | An ISO standard for blood transfusion? |
| cord-023346-8sqbqjm1 | Are transfusion guidelines evidence- based? |
| cord-023346-8sqbqjm1 | Being anti- D immunoglobulin a product that has the potential risk of infection transmission, is it appropriate to use indiscriminately as a routine antenatal prophylaxis? |
| cord-023346-8sqbqjm1 | In addition, how much are we willing to pay for protection against emerging viruses? |
| cord-023346-8sqbqjm1 | Is it a mutual decision making between physician and patient? |
| cord-023346-8sqbqjm1 | Mobilization is also seen following the use of other cytokines( i.e. kit- L, Flt-3 L, IL-3) or chemokines( i.e. IL-8, Gro?), complement activation, etc., but the detailed mechanisms or the interdependence of these other pathways with the ones already proposed have not been worked out. |
| cord-023346-8sqbqjm1 | Scientific evidence to fully answer the questions'when are platelet components clinically effective'and'what do we really know?'is limited. |
| cord-023346-8sqbqjm1 | Should patients with thalassemia intermedia be regularly transfused? |
| cord-023346-8sqbqjm1 | The research theme of this questionnaire is as follows:'What is the level of knowledge and of motivation in the non- remunerated and voluntary blood donation at students?' |
| cord-023346-8sqbqjm1 | The subjects selected and debated were( i) what are the medical considerations for reducing the rate of mistransfusion? |
| cord-023346-8sqbqjm1 | These ties to industry create a tension that actually is or can be perceived as • work internationally; • send young volunteers to international youth forums; • employ young people in your organisation; Why use volunteers in blood donor recruitment? |
| cord-023346-8sqbqjm1 | We therefore resorted to developing our own model but ask the question: Why not have one international standard for blood transfusion? |
| cord-023346-8sqbqjm1 | What is however the meaning of informed consent? |
| cord-023346-8sqbqjm1 | Who cares about the quality of life of the chronic patients treated with blood products? |
| cord-023346-8sqbqjm1 | Who will hear it? |
| cord-023346-8sqbqjm1 | and( ii) what are the medical considerations for managing a limited blood inventory? |
| cord-023346-8sqbqjm1 | to apply which screening method? |
| cord-023346-8sqbqjm1 | your Trima ® can be? |
| cord-018133-2otxft31 | Equally important, how are the proteins turned off? |
| cord-018133-2otxft31 | For example, they could provide:( 1) the ability to guess the function of a new protein by assessing its similarity to E. coli genes with a similar sequence,( 2) the ability to ask what the effect on an organism would be if a critical component of a pathway were removed( would other pathways be used to create the desired function, or would the organism lose a vital function and die?), and( 3) the ability to provide a rich user interface to the literature on E. coli metabolism. |
| cord-018133-2otxft31 | GENBANK can be searched efficiently with a number of algorithms and is usually the first stop for a scientist with a new sequence who wonders"Has a sequence like this ever been observed before? |
| cord-018133-2otxft31 | Given two sets of threedimensional coordinates for a set of atoms, what is the best way to superimpose them so that the similarities and differences between the two structures are clear? |
| cord-018133-2otxft31 | How can we analyze the structures of molecules to learn their associated function? |
| cord-018133-2otxft31 | How can we extend the limited structural data by using information in the sequence databases about closely related proteins from different organisms( or within the same organism, but performing a slightly different function)? |
| cord-018133-2otxft31 | How do the proteins function once there? |
| cord-018133-2otxft31 | How does it respond to these medications? |
| cord-018133-2otxft31 | How has the age of genomics changed the landscape of bioinformatics? |
| cord-018133-2otxft31 | How should structures be grouped for the purposes of classification? |
| cord-018133-2otxft31 | If one has, what is known about it? |
| cord-018133-2otxft31 | In addition, the neighbors of a sequence element are also critical, and it is important to be able to perform queries such as,"What sequence elements are seen 20 elements to the left of this element? |
| cord-018133-2otxft31 | It is necessary to support queries such as,"What sequence motifs are present in this sequence? |
| cord-018133-2otxft31 | It provides an excellent introduction to basic molecular biology and biochemistry what ways will bioinformatics and medical informatics interact in the future? |
| cord-018133-2otxft31 | Once genes are transcribed and translated into proteins, into what cellular compartment are the proteins directed? |
| cord-018133-2otxft31 | One of the critical questions facing the genome- sequencing projects is"Can genetic information be misused?" |
| cord-018133-2otxft31 | Should a chapter on bioinformatics appear in a clinical informatics textbook? |
| cord-018133-2otxft31 | Should a patient be informed that he or she is likely to get a disease for which there is no treatment? |
| cord-018133-2otxft31 | The simulation would be a complex mathematical model in which all the molecular details of each organ system would be represented in sufficient detail to allow complex"what if?" |
| cord-018133-2otxft31 | What are two computational challenges in bioinformatics for the future? |
| cord-018133-2otxft31 | What are two problems encountered in analyzing biological sequence, structure, and function? |
| cord-018133-2otxft31 | What is the standard course for this disease? |
| cord-018133-2otxft31 | What more natural user interface could there be for exploring physiology, anatomy, genetics, and biochemistry than the universally recognizable structure of a human that could be browsed at both macroscopic and microscopic levels of detail? |
| cord-018133-2otxft31 | What two changes should we anticipate in the medical record as a result of these new information sources? |
| cord-018133-2otxft31 | When are genes turned on? |
| cord-018133-2otxft31 | Where on the Internet should you look for a DNA sequence, a protein sequence, or a protein structure? |
| cord-018133-2otxft31 | Why have biologists and bioinformaticians embraced the Web as a vehicle for disseminating data so quickly, whereas clinicians and clinical informaticians have been more hesitant to put their primary data online? |
| cord-018133-2otxft31 | Why is sequence, structure, and biological pathway information relevant to medicine? |
| cord-018133-2otxft31 | Why should an awareness of bioinformatics be expected of clinical informatics professionals? |
| cord-018133-2otxft31 | Will the introduction of DNA and protein sequence information change the way that medical records are managed in the future? |
| cord-018133-2otxft31 | Will the same problems arise in basic biomedical research? |
| cord-023354-f2ciho6o | ( with a selfadministered questionnaire with an open- ended question: How does blood donation affect you? |
| cord-023354-f2ciho6o | /socially during or after blood donation?) revealed that perceived negative effects( fatigue, diminished physical working capacity, vertigo/ dizziness, susceptibility to infections etc) |
| cord-023354-f2ciho6o | : will it become reality? |
| cord-023354-f2ciho6o | After the first 10 years with haemovigilance in the European countries, what has been the outcome of this big effort? |
| cord-023354-f2ciho6o | Against this background where should our attentions focus? |
| cord-023354-f2ciho6o | Aim: Does the interpretation of reports obtained through Outcome Review lead to an increase in the number of products per run and the overall productivity of the apheresis center? |
| cord-023354-f2ciho6o | An ISO standard for blood transfusion? |
| cord-023354-f2ciho6o | Are transfusion guidelines evidence- based? |
| cord-023354-f2ciho6o | Being anti- D immunoglobulin a product that has the potential risk of infection transmission, is it appropriate to use indiscriminately as a routine antenatal prophylaxis? |
| cord-023354-f2ciho6o | In addition, how much are we willing to pay for protection against emerging viruses? |
| cord-023354-f2ciho6o | Is it a mutual decision making between physician and patient? |
| cord-023354-f2ciho6o | Mobilization is also seen following the use of other cytokines( i.e. kit- L, Flt-3 L, IL-3) or chemokines( i.e. IL-8, Gro?), complement activation, etc., but the detailed mechanisms or the interdependence of these other pathways with the ones already proposed have not been worked out. |
| cord-023354-f2ciho6o | Scientific evidence to fully answer the questions'when are platelet components clinically effective'and'what do we really know?'is limited. |
| cord-023354-f2ciho6o | Should patients with thalassemia intermedia be regularly transfused? |
| cord-023354-f2ciho6o | The research theme of this questionnaire is as follows:'What is the level of knowledge and of motivation in the non- remunerated and voluntary blood donation at students?' |
| cord-023354-f2ciho6o | The subjects selected and debated were( i) what are the medical considerations for reducing the rate of mistransfusion? |
| cord-023354-f2ciho6o | These ties to industry create a tension that actually is or can be perceived as • work internationally; • send young volunteers to international youth forums; • employ young people in your organisation; Why use volunteers in blood donor recruitment? |
| cord-023354-f2ciho6o | We therefore resorted to developing our own model but ask the question: Why not have one international standard for blood transfusion? |
| cord-023354-f2ciho6o | What is however the meaning of informed consent? |
| cord-023354-f2ciho6o | Who cares about the quality of life of the chronic patients treated with blood products? |
| cord-023354-f2ciho6o | Who will hear it? |
| cord-023354-f2ciho6o | and( ii) what are the medical considerations for managing a limited blood inventory? |
| cord-023354-f2ciho6o | to apply which screening method? |
| cord-023354-f2ciho6o | your Trima ® can be? |
| cord-023211-kt5gt26t | 2) Were there any adverse haematological effects with the use of oral chloramphenicol at RBH? |
| cord-023211-kt5gt26t | 4) Was the parent diagnosed before or after pregnancy was confirmed? |
| cord-023211-kt5gt26t | 6) Was the parent's diagnosis a result of prenatal testing? |
| cord-023211-kt5gt26t | Do pre- packaged salt packets contain a precise amount of sodium and thus could be recommended to fulfill the daily requirement of sodium in patients with CF? |
| cord-023211-kt5gt26t | Do you presently care for any patients with CF who have given birth to, or fathered a CF affected child? |
| cord-023211-kt5gt26t | Does CF patient age or ethnicity increase the likelihood of hearing loss as determined by a hearing questionnaire? |
| cord-023211-kt5gt26t | Does gender play a role in perception of CF quality of life domains before and after lung transplantation? |
| cord-023211-kt5gt26t | Fukushima, L.K.; Hsu, E.; Woo, M.S. Division of Pediatric Pulmonology, Childrens Hospital Los Angeles, Los Angeles, CA, USA Do Hispanic and Caucasian CF patients share the same frequency of pulmonary exacerbations? |
| cord-023211-kt5gt26t | How effective is chloramphenicol in comparison to ciprofloxacin? |
| cord-023211-kt5gt26t | How many patients at your center have had CF affected children? |
| cord-023211-kt5gt26t | If parent's diagnosis came after conception, was this after child was diagnosed? |
| cord-023211-kt5gt26t | Is the increased morbidity/ mortality risk due to decreased access to outpatient CF care? |
| cord-023211-kt5gt26t | The potentially protective effects of the now available HPV vaccination in females and males? |
| cord-023211-kt5gt26t | Thirty- five% of parents in group A and 53% in group B changed their family planning projects following the diagnosis PHYSICAL HEALTH AND ANXIETY SYMPTOMS: DOES MONITORING MEDIATE THE RELATION? |
| cord-023211-kt5gt26t | This study aimed to address three questions: 1) What proportion of PSA is sensitive to ciprofloxacin and/or chloramphenicol? |
| cord-023211-kt5gt26t | What are the results of hearing questionnaires administered to pediatric CF patients? |
| cord-023211-kt5gt26t | What is the estimated incidence of CF patients having CF affected children attending accredited CF centers in the United States? |
| cord-022940-atbjwpo5 | , What is the role of Ministry of Health? |
| cord-022940-atbjwpo5 | Are antibiotics against which the strain is resistant inducing the changes in bacterial proteome? |
| cord-022940-atbjwpo5 | Can YKL-40 be an inflammatory biomarker in vitamin D deficiency? |
| cord-022940-atbjwpo5 | Hemolysis and test rejection: are we following a reliable process? |
| cord-022940-atbjwpo5 | His- flag tag as a fusion partner in insect expression systemgain or loss? |
| cord-022940-atbjwpo5 | How does different lead levels affect TSH, FT3, FT4, vitamin B12 and folate? |
| cord-022940-atbjwpo5 | How preeclampsia affects oxidant status and antiinflammatory potential of breast milk? |
| cord-022940-atbjwpo5 | Is this strain characterized by other differences on a proteome level? |
| cord-022940-atbjwpo5 | It was intended to shed light on some questions such as, what is the place and importance of IVD in Turkey? |
| cord-022940-atbjwpo5 | MRM transitions used were m/ z? 250/164 for 8-iso- PGF 2a and m/ z? |
| cord-022940-atbjwpo5 | MRM transitions used were m/ z? 250/164 for 8-iso- PGF 2a and m/ z? |
| cord-022940-atbjwpo5 | Medical and biological illustrations for life sciences education: Is'a picture worth a thousand words'in visualizing medicine and science? |
| cord-022940-atbjwpo5 | P-04.01.1- 006 Host- pathogen interactions: is there a relationship between TLR 4 polymorphisms and tuberculosis in a group of Turkish patients? |
| cord-022940-atbjwpo5 | P-05.01.1- 015 Does causes 1800 MHz magnetic field application KRAS and P53 mutations in colon?: |
| cord-022940-atbjwpo5 | P-09.04.4- 108 Is there any relation between 50 g oral glucose challenge test and serum total oxidant- antioxidant status in pregnant woman? |
| cord-022940-atbjwpo5 | What are the responsibilities of educational institutions? |
| cord-022940-atbjwpo5 | What is extra to learn from protein drying measurements? |
| cord-264746-gfn312aa | & What is the chance of seeing a block of high G+C nucleotides shorter than 5000? |
| cord-264746-gfn312aa | ( e.g., is it likely for a block of high G+C to follow a block of low G+C?). |
| cord-264746-gfn312aa | 13.17? |
| cord-264746-gfn312aa | Do any of them have similar profiles? |
| cord-264746-gfn312aa | Furthermore, how does one select the scores for matches, mismatches, and indels? |
| cord-264746-gfn312aa | How does one determine which of the 129 possibilities is best? |
| cord-264746-gfn312aa | How large( or small) must the ratio be to say that the expression levels are really different?'' |
| cord-264746-gfn312aa | How long would it take to find the best alignment of two 1000 bp sequences by exhaustive search? |
| cord-264746-gfn312aa | How many chromosomes does it have? |
| cord-264746-gfn312aa | How many genes does it have? |
| cord-264746-gfn312aa | How many mammalian genomes have been completely sequenced? |
| cord-264746-gfn312aa | How many matches to that oligonucleotide would one expect to find in the human genome? |
| cord-264746-gfn312aa | How many possible proteins could be formed by a gene region containing four exons? |
| cord-264746-gfn312aa | How might this fact be used in gene finding algorithms? |
| cord-264746-gfn312aa | If each of the 13 SSR markers used by the FBI for identification purposes has 20 equally frequent alleles, what is the chance that two randomly chosen individuals have the same collection of alleles at those 13 markers? |
| cord-264746-gfn312aa | If one of these synonymous codons is energetically more efficient for the organism to use, what effect would that have on the organism's genome content? |
| cord-264746-gfn312aa | If the quantities are measured at the level of entire exons( e.g., did the algorithm correctly predict the location of the entire exon or not?), the values drop to around 70%. |
| cord-264746-gfn312aa | Phrased differently, would a ratio near 0.27 for spot 4 be likely if the experiment were repeated? |
| cord-264746-gfn312aa | The expression levels for two genes measured at four times are: implication of the correlation coefficient? |
| cord-264746-gfn312aa | This database makes it possible to take a query sequence and, for each of the 7500 families and their associated profile HMMs, ask the question,''Is the query sequence a member of this gene family?'' |
| cord-264746-gfn312aa | What are possible advantages and disadvantages of introns? |
| cord-264746-gfn312aa | What are they? |
| cord-264746-gfn312aa | What does the result tell you about zinc finger genes? |
| cord-264746-gfn312aa | What is the chance that a 20-nucleotide oligonucleotide matches a sequence other than the one it was designed to match? |
| cord-264746-gfn312aa | What is the length of the Drosphila melanogaster alcohol dehydrogenase gene? 9. |
| cord-264746-gfn312aa | What is the size of the Anopheles gambiae genome? |
| cord-000248-zueoyesj | /ml undergoing radical prostatectomy for prostate cancer? |
| cord-000248-zueoyesj | : What's new?]. |
| cord-000248-zueoyesj | A natural question arises:''Which is the significance of another set, now arbitrarily chosen to be also of the same cardinality( i.e 44 genes) with the complementary behavioural pattern?''We have now listed all the probes according to Diff. |
| cord-000248-zueoyesj | A thermodynamic interpretation of malignancy: do the genes come later? |
| cord-000248-zueoyesj | After observing that Figure 14 shows a correlation of Gleason pattern score with Normalized Shannon Entropy, we asked ourselves:'which are the genes that most positively and negatively correlate with the transitions of Normalized Shannon Entropy?' |
| cord-000248-zueoyesj | Another natural question can be asked: Which is the extra information that we can obtain the by analysing the correlations with the MPR- Statistical Complexity in this case? |
| cord-000248-zueoyesj | Can Entropy and''order''increase together? |
| cord-000248-zueoyesj | Can Shannon Entropy increase while the Normalized Shannon Entropy decrease?'' |
| cord-000248-zueoyesj | Can we quantify the chaos observed in the genome from the increasingly available transcriptional data and relate it to tumour progression?'' |
| cord-000248-zueoyesj | Could changes of key physical parameters for metabolic processes of the cytoplasm and cell's organelles like temperature, volume, pH or electrochemical potentials be also implicated in cancer progression? |
| cord-000248-zueoyesj | Could it be possible that we can track cancer progression by looking at some of these''Maxwell demons''? |
| cord-000248-zueoyesj | Could this be another hallmark for oncosystems indentification? |
| cord-000248-zueoyesj | Does a similar pattern of aquaporin downregulation exist in prostate cancer? |
| cord-000248-zueoyesj | However, in a manuscript entitled''Can Entropy and'order'increase together?'' |
| cord-000248-zueoyesj | In a letter to Peter Guthrie Tait, Maxwell writes about the''demons'':''Is the production of an inequality of temperature their only occupation? |
| cord-000248-zueoyesj | Is aquaporin-3 just a glycerol transporter Physiological roles of glyceroltransporting aquaporins: the aquaglyceroporins A role for mitochondrial aquaporins in cellular life- and- death decisions? |
| cord-000248-zueoyesj | Multifunctional proteins or just regulators of desmosomal adhesion? |
| cord-000248-zueoyesj | Multivariate gene expression analysis reveals functional connectivity changes between normal/ tumoral prostates PSA response signatures-a powerful new prognostic indicator after radiation for prostate cancer? |
| cord-000248-zueoyesj | Osteopontin expression correlates with melanoma invasion Osteopontin in melanocytic lesions- a first step towards invasion? |
| cord-000248-zueoyesj | Possible immunoprotective and angiogenesis- promoting roles for malignant cell- derived prostasomes: a new paradigm for prostatic cancer? |
| cord-000248-zueoyesj | Reactive oxygen species: a breath of life or death? |
| cord-000248-zueoyesj | The rate of lymph node invasion( LNI) in men with PSA values less than 10 ng/ ml Pelvic lymph node irradiation for prostate cancer: who, why, and when? |
| cord-000248-zueoyesj | The story of the discovery of aquaporins: convergent evolution of ideas- but who got there first? |
| cord-000248-zueoyesj | This poses the question: What can we observe while looking at the genes that most positively correlate with the loss of Normalized Shannon Entropy? |
| cord-000248-zueoyesj | What are the consequences if cancer cells are a different type of open system which also operates at a different temperature than a normal cell? |
| cord-000248-zueoyesj | What consequences is this''system''delivering? |
| cord-000248-zueoyesj | What do we learn from molecular dynamics simulations? |
| cord-000248-zueoyesj | What really prevents proton transport through aquaporin? |
| cord-000248-zueoyesj | Which key mechanisms might be impaired? |
| cord-000248-zueoyesj | Which types of mechanisms exist in biological systems, and particularly in individual cells, to control these differential values in key parameters? |
| cord-000248-zueoyesj | Why is it the case that we observe the Normalized Shannon Entropy of the transcriptional profile decreasing with cancer progression when intuitively our average expected surprisal( Shannon Entropy) should increase with progression? |
| cord-000248-zueoyesj | implications for Dunnigan- type familial partial lipodystrophy A- type lamins: guardians of the soma? |
| cord-000248-zueoyesj | nonclassic CCAAT enhancer element binding protein binding site contributes to alpha- methylacyl- CoA racemase expression in prostate cancer Sequence variants of alpha- methylacyl- CoA racemase are associated with prostate cancer risk How often does alphamethylacyl- CoA- racemase contribute to resolving an atypical diagnosis on prostate needle biopsy beyond that provided by basal cell markers? |
| cord-000248-zueoyesj | nuclear mRNA export is coupled to ongoing gene transcription Splicing speckles are not reservoirs of RNA polymerase II, but contain an inactive form, phosphorylated on serine2 residues of the C- terminal domain Regulating gene expression through RNA nuclear retention P54nrb forms a heterodimer with PSP1 that localizes to paraspeckles in an RNA- dependent manner Dynamics of the mammalian nucleus: can microscopic movements help us to understand our genes? |
| cord-000248-zueoyesj | relationship to melanocyte and keratinocyte carcinogenesis Contribution of p53, p63, and p73 to the developmental diseases and cancer and p63: why do we still need them? |
| cord-000248-zueoyesj | the possibility of exporting entropy'', could it lead to some type of''genetic alterations''? |
| cord-000248-zueoyesj | tumors Plakoglobin is required for effective intermediate filament anchorage to desmosomes Plakophilins- hard work in the desmosome, recreation in the nucleus? |
| cord-010092-uftc8inx | Can you confirm my genotype? cord-010092-uftc8inx Who is a blood donor recruiter?"was the topic of ABD- VII at 9- 11 March 2018. |
| cord-010092-uftc8inx | 4A- S18- 05 WHO IS SYPHILIS TESTING EXCLUDING? |
| cord-010092-uftc8inx | : IS IT TIME TO LABEL EACH UNIT WITH HB CONTENT? |
| cord-010092-uftc8inx | A donor was classified as"tired"if they responded"all the time"or"most of the time"to the question"how often do you feel that you lacked energy and strength?". |
| cord-010092-uftc8inx | ALL TOGETHER? |
| cord-010092-uftc8inx | Are we alone in the Universe? |
| cord-010092-uftc8inx | As a consequence, questions asked 30 years ago have changed: Today, molecular biologists looking at hundreds of newly discovered blood group alleles find themselves not being asked by serologists any more:"Can you confirm my serology?", but instead, pose their question to the experts for the blood group phenotype: |
| cord-010092-uftc8inx | But can we apply the metaphor as successfully into donating blood for research? |
| cord-010092-uftc8inx | Donors and Donation-Donor Adherence-are we doing the Right Thing? |
| cord-010092-uftc8inx | How can we start using this tool in unison with our existing tools to improve science and clinical practice in our respective( bio)medical fields? |
| cord-010092-uftc8inx | So is there a future for new anti- platelet agents? |
| cord-010092-uftc8inx | To evaluate self- rated health we used the well- validated single question:"How would you rate your health in general?". |
| cord-010092-uftc8inx | WHAT CAN WE LEARN FROM HOW ADVERSE EVENTS ARE DETECTED? |
| cord-010092-uftc8inx | What is the optimal balance between iron supplementation and prolongation of interdonation intervals? |
| cord-010092-uftc8inx | What then is the best approach to use? |
| cord-010092-uftc8inx | Where are we from? |
| cord-010092-uftc8inx | Where are we going? |
| cord-010092-uftc8inx | Will serologic typing be replaced by DNAbased typing? |
| cord-010092-uftc8inx | but how does this affect health? |
| cord-010119-t1x9gknd | Among all potential causes investigated, only the gel card lot number was associated with the number of"?"generated( table 1). |
| cord-010119-t1x9gknd | Assuming 30 seconds of technologist time per"?", we estimate that 13.6 hours were needed to resolve and update these results. |
| cord-010119-t1x9gknd | Can Texting Decrease Wastage? |
| cord-010119-t1x9gknd | Interference: More Than Just Kell? |
| cord-010119-t1x9gknd | Is Its Use Inappropriate? |
| cord-010119-t1x9gknd | Of 19,647 columns run as part of antibody screens, 1,633( 8.3%) columns generated"? |
| cord-010119-t1x9gknd | Patient 1 was a 29 yo female, C2E2c1e1, whose RBCs reacted 11 by ECHO and 31 by NEO with anti- D4, and'?' |
| cord-010119-t1x9gknd | Platelet Rich Plasma and Quality Control: Is There a Role for the Blood Bank? |
| cord-010119-t1x9gknd | Shortly after implementation, technologists reported increased time spent performing manual resolution of indeterminate( designated as"?") results. |
| cord-010119-t1x9gknd | Study Design/ Method: We analyzed allogeneic interview responses to the screening question,"In the past 12 months have you had a tattoo?" |
| cord-010119-t1x9gknd | Study Design/ Methods: With assistance from Ortho Diagnostics, analyzer archives were queried to identify the number of gel card columns used for screens, the number of columns with"?"results, and the gel card lot numbers used for testing from 1/29/2017 to 3/31/2017. |
| cord-010119-t1x9gknd | Testing Worth the Headache? |
| cord-010119-t1x9gknd | Texas Children's Hospital, 2 Baylor College of Medicine AP127 Vision Titers--Easier or Problematic? |
| cord-010119-t1x9gknd | The Future of Plasma Therapy? |
| cord-010119-t1x9gknd | The incidence of"?"and visually negative analyzer positive results is dependent on the specific lot of MTS- Gel TM cards used. |
| cord-010119-t1x9gknd | The objective of this study was to investigate the cause of"?"and apparent false positive results on VisionV R three- cell antibody screens. |
| cord-010119-t1x9gknd | Variations in Biochemical Markers of Bone Metabolism during Plateletpheresis: Impact of Socio- Demographic and Lifestyle Factors? |
| cord-010119-t1x9gknd | Were Patients Transfused after Testing? |
| cord-010119-t1x9gknd | What Is the Best Practice for Testing Residual White Blood Cells in Blood Components for Monthly Routine Quality Control? |
| cord-010119-t1x9gknd | Where We Go? |
| cord-026025-xqj877en | : Are they resolvable? |
| cord-026025-xqj877en | : Is there a link? |
| cord-026025-xqj877en | : Is there an association? |
| cord-026025-xqj877en | : Pathologic and histochemical study of mucosal biopsy specimens Pouchitis: Is it a wastebasket diagnosis? |
| cord-026025-xqj877en | : Why does it only occur in parts of Europe? |
| cord-026025-xqj877en | A clinicopathologic study of 33 cases of focal active colitis: Does it ever represent Crohn's disease? |
| cord-026025-xqj877en | A clinicopathological confrontation of lymphocytic and collagenous colitis Drug- induced lymphocytic colitis Ranitidine, diarrhea, and lymphocytic colitis Focal lymphocytic colitis and collagenous colitis: Patterns of Crohn's colitis? |
| cord-026025-xqj877en | A condition different from ulcerative proctitis? |
| cord-026025-xqj877en | A nonspecific finding related to mucosal prolapse Histologic features of mycophenolate mofetil- related colitis: A graft- versus- host diseaselike pattern The Pathology of Bone Marrow Transplantation Gastrointestinal pathology in patients with common variable immunodeficiency and X- linked agammaglobulinemia Small intestinal lesion resembling graft- vs- host disease: A case report in immunodeficiency and review of the literature Graft- versus- host disease- like syndrome in malignant thymoma Enteropathy associated with the acquired immunodeficiency syndrome Ultrastructural features of epithelial degeneration in rectal crypts of patients with AIDS Collagenous colitis"with watery diarrhea: A new entity? |
| cord-026025-xqj877en | A rational decision concerning management of a patient with an endoscopically removed malignant colorectal polyp( one containing invasive adenocarcinoma) requires weighing the chances of finding residual or metastatic cancer with a follow- up surgical excision( whom do I help?) |
| cord-026025-xqj877en | Aganglionosis and related disorders Does zonal aganglionosis really exist? |
| cord-026025-xqj877en | An indication for colectomy The fate of low- grade dysplasia in ulcerative colitis Observer study of the grading of dysplasia in ulcerative colitis: Comparison with clinical outcome Inter- observer variation between general and specialist pathologists when grading dysplasia in ulcerative colitis Colonoscopic surveillance for cancer in patients with chronic ulcerative colitis: Is it working? |
| cord-026025-xqj877en | Are abnormalities present? |
| cord-026025-xqj877en | Are colonic tubules straight? |
| cord-026025-xqj877en | Are crypt abscesses present? |
| cord-026025-xqj877en | Are inflammatory cells increased in the lamina propria or epithelium? |
| cord-026025-xqj877en | Are we telling patients the truth about surveillance colonoscopy in ulcerative colitis? |
| cord-026025-xqj877en | Are"solitary"rectal ulcer syndrome and"localized"colitis cystica profunda analogous syndromes caused by rectal prolapse? |
| cord-026025-xqj877en | Can we stop looking? |
| cord-026025-xqj877en | Clinicopathologic study of 18 patients in comparison to collagenous colitis Collagenous colitis: Pathogenesis and management Short- and long- term follow- up of treatment for lymphocytic and collagenous colitis Systematic review: Microscopic colitis Collagenous colitis in the setting of nonsteroidal anti- inflammatory drugs and antibiotics Lymphocytic colitis: A distinct clinical entity? |
| cord-026025-xqj877en | Cure by colonoscopy or colectomy? |
| cord-026025-xqj877en | Do the colonic tubules reach the muscularis mucosae or are they short, branched, or budded? |
| cord-026025-xqj877en | Does the lesion represent a harmless sporadic adenoma or is it a dangerous DALM? |
| cord-026025-xqj877en | How closely are they related to inflammatory fibroid polyps? |
| cord-026025-xqj877en | If intracellular mucin is depleted, is this change focal or diffuse? |
| cord-026025-xqj877en | If present, are the changes diffuse or focal? |
| cord-026025-xqj877en | Is intraepithelial mucin( the goblet cell population) preserved or depleted? |
| cord-026025-xqj877en | Is the lamina propria obliterated by fibrous or fibromuscular tissue? |
| cord-026025-xqj877en | Is the luminal border of the specimen straight or irregular? |
| cord-026025-xqj877en | Is this increase diffuse or focal? |
| cord-026025-xqj877en | Mucosal pseudolipomatosis of the colon A case of colonic pseudolipomatosis: A rare complication of colonoscopy? |
| cord-026025-xqj877en | Pathology working group report Chronic mucosal changes of the colon in graft- versus- host disease Emerging concepts of proctosigmoiditis Observations on idiopathic proctitis Diagnosis and treatment of ulcerative proctitis Diverticular disease and chronic idiopathic inflammatory bowel disease: Associations and masquerades Crohn's disease of the colon and its distinction from diverticulitis Granulomatous inflammation in sigmoid diverticulitis: Two diseases or one? |
| cord-026025-xqj877en | The care of patients with colorectal polyps that contain invasive adenocarcinoma: Endoscopic polypectomy or colectomy? |
| cord-026025-xqj877en | What does it mean? |
| cord-026025-xqj877en | What kind of inflammatory cells are they? |
| cord-026025-xqj877en | against the risk of surgical mortality and morbidity( whom do I hurt?). |
| cord-026025-xqj877en | gastrointestinal mucosal mast cells increased in patients with systemic mastocytosis? |
| cord-026025-xqj877en | predicts future development of dysplasia in ulcerative colitis Flow cytometric and histological progression to malignancy in Barrett's esophagus: Prospective endoscopic surveillance of a cohort Dysplasia in ulcerative colitis: Aneuploidy versus morphology Colonoscopic surveillance for cancer in patients with chronic ulcerative colitis: Is it working? |
| cord-264884-ydkigome | ,, 2005? |
| cord-264884-ydkigome | A subset of human immunodefi ciency virus type 1 long- term nonprogressors is characterized by the unique presence of ancestral sequences in the viral population Does common architecture reveal a viral lineage spanning all three domains of life? |
| cord-264884-ydkigome | Accordingly, when contemplating the amazing complexity of the P1 immunity and how it evolved, Yarmolinsky posed the question;"Could the byzantine complexity of the controls at ImmI be the outcome, not of successive host- parasite accommodations, but of competition among related phages?" |
| cord-264884-ydkigome | Also, how do we defi ne information content or integrity of a consortia? |
| cord-264884-ydkigome | Can cooperation( or consortia behavior) result from any of these models? |
| cord-264884-ydkigome | Can this be considered an example of symbiosis in the accepted sense? |
| cord-264884-ydkigome | Could the adaptation to a host- specifi c persistence- based basal life strategy provide some explanations for the evolution of the higher fi delity RNA replicase of these coronaviruses? |
| cord-264884-ydkigome | DNA Viral eukaryogenesis: was the ancestor of the nucleus a complex DNA virus? |
| cord-264884-ydkigome | Did the need and selection for a larger genome override the use of error to generate adaptability as seen in poliovirus and HIV-1? |
| cord-264884-ydkigome | Does such a distributed pattern of evolution and gene novelty also apply to the phycodnaviruses? |
| cord-264884-ydkigome | Here a virus, there a virus, everywhere the same virus? |
| cord-264884-ydkigome | How can genetic complexity be created in such a circumstance? |
| cord-264884-ydkigome | How do we defi ne such fi tness since the mixture clearly matters? |
| cord-264884-ydkigome | How does MHV attain such stable and prevalent persistence in natural population yet retain the ability to cause disease in naive populations? |
| cord-264884-ydkigome | How generally important is this poliovirus in vivo quasispecies result? |
| cord-264884-ydkigome | How important are viruses in general to evolutionary biology? |
| cord-264884-ydkigome | How is information stability and higher fi tness attained with such errors? |
| cord-264884-ydkigome | How might such selection operate in natural populations? |
| cord-264884-ydkigome | How might we explain the increased fi delity and genome size of the nidoviruses? |
| cord-264884-ydkigome | How then do we link poxvirus evolution to other more ancient DNA viruses, such as PBCV-1 which has the same DNA replication mechanism, but distinct replication proteins? |
| cord-264884-ydkigome | If so, what selective pressures might have changed this seemingly basic feature? |
| cord-264884-ydkigome | If so, why is it that in sheep a distinctly different lineage of retrovirus( enJSRV) was also selected to provide a related placental function to a another mammal with signifi cantly different placental reproductive biology? |
| cord-264884-ydkigome | If we can accept the above conclusion concerning the role for viruses in the evolution of prokaryotes, we must then ask why such a successful evolutionary strategy was not apparently maintained in eukaryotes? |
| cord-264884-ydkigome | Is there any evidence that this result with poliovirus indeed represents a general virus- host evolutionary relationship in natural settings? |
| cord-264884-ydkigome | Protein repertoire of double- stranded DNA bacteriophages Characterization of the primary immunity region of the Escherichia coli linear plasmid prophage N15 Parvovirus variation for disease: a difference with RNA viruses? |
| cord-264884-ydkigome | Was there some change in viral adaptation in which quasispecies and generation of mixtures was no longer as important for adaptation? |
| cord-264884-ydkigome | Was this ERVL colonization of relevance to the ancient co- speciation of simian foamy virus and their primate host( Switzer et al., 2005)? |
| cord-264884-ydkigome | What could be more fascinating than a green sea slug- an animal that can use light for photosynthesis? |
| cord-264884-ydkigome | What do we know about the natural biology of these viruses, which might provide some insight into this? |
| cord-264884-ydkigome | What does structure tell us about virus evolution? |
| cord-264884-ydkigome | What exactly was the relevance of HERV endogenization to human survival and adaptations? |
| cord-264884-ydkigome | What is the fi tness consequence to the colony harboring MHV relative to its uninfected neighbor? |
| cord-264884-ydkigome | What maintains the MHV fi tness of natural persistence? |
| cord-264884-ydkigome | What then is the evolutionary relationship that links all of these seemingly distinct viruses? |
| cord-264884-ydkigome | What then is the fi tness and evolutionary consequence to E. coli harboring P1? |
| cord-264884-ydkigome | What was the role for SIV in the evolution of primate MHC( Vogel et al., 1999)? |
| cord-264884-ydkigome | Why is this relationship stable? |
| cord-264884-ydkigome | Why should prokaryotes and eukaryotes differ is such a fundamental way? |
| cord-264884-ydkigome | Why? |
| cord-264884-ydkigome | Why? |
| cord-264884-ydkigome | human and chimpanzee MHC I( Watkins, 1995; Kulski et al., 1999)? |
| cord-264884-ydkigome | tailed DNA bacteriophages Do viruses form lineages across different domains of life? |
| cord-017208-7oew461e | ( For replication- selective vectors, what is the molecular basis of the selectivity and the conditions under which the vector would replicate?) |
| cord-017208-7oew461e | Are alternative methods of selection available? |
| cord-017208-7oew461e | Are data available evaluating the genetic stability of the recombinant vector? |
| cord-017208-7oew461e | Are data available evaluating the potential for genetic recombination with other organisms in the patient or in the environment? |
| cord-017208-7oew461e | Are the biological features of the vector, and its transgene when applicable, clearly similar in the animal species used for safety studies and in the human, at least as far as this can be ascertained? |
| cord-017208-7oew461e | Are there any safety issues connected with the production, purification, and/or handling of the product? |
| cord-017208-7oew461e | Are there issues of formulation that must be resolved? |
| cord-017208-7oew461e | Are there reproducible assays for the product? |
| cord-017208-7oew461e | Can successive batches of the material be made reproducibly in the quantity to support clinical development, and how is this known? |
| cord-017208-7oew461e | Do you have any information regarding the estimated costs of this production project? |
| cord-017208-7oew461e | Does the construct contain an antibiotic resistance gene or other selectable marker? |
| cord-017208-7oew461e | Does the vector have an altered cell tropism? |
| cord-017208-7oew461e | For example, are the safety issues primarily related to the vector, the transgene product, the method of administration, the formulation/ excipient, or some combination of the above? |
| cord-017208-7oew461e | For example, would there be an advantage to performing the studies in rodents when larger numbers of animals might be more practical, or is there a necessity for a large animal model, such as a canine or nonhuman primate? |
| cord-017208-7oew461e | Has a source of funding been identified for performing the clinical trial with this product? |
| cord-017208-7oew461e | Has this construct been sequenced? |
| cord-017208-7oew461e | Has this material been produced in a related or other production system? |
| cord-017208-7oew461e | Has this material ever been produced for laboratory or clinical studies using this production system? |
| cord-017208-7oew461e | Have there been any meetings scheduled with regulatory agencies, such as a pre- IND meeting with the FDA or a presentation to the NIH RAC? |
| cord-017208-7oew461e | Have you identified any possible sources of production with any commercial firms? |
| cord-017208-7oew461e | How does one know that a lot of product is qualified for use? |
| cord-017208-7oew461e | How does this scale to anticipated quantities for clinical trial? |
| cord-017208-7oew461e | How might existing published or unpublished nonclinical or clinical data address the questions mentioned above? |
| cord-017208-7oew461e | How much material is available as a reference standard? |
| cord-017208-7oew461e | How will the presence and distribution of the gene therapy agent be followed in the patient? |
| cord-017208-7oew461e | If nonhuman primate studies are proposed, is it clear that another large animal or rodent model would not provide the same information? |
| cord-017208-7oew461e | If not, is there a qualified cell line available for propagation of this vector? |
| cord-017208-7oew461e | If you have had a pre- IND or RAC meeting, were any issues concerning manufacturing, safety, or stability raised that will have an impact on producing your product? |
| cord-017208-7oew461e | In broad strokes, these involve approaches to answering the following questions: Is the identity of the agent clearly defined? |
| cord-017208-7oew461e | In what form( lyophilized, formulated product, and so on) and fill size is the desired final product? |
| cord-017208-7oew461e | Is material available as bulk biological substance for preliminary pharmacology and toxicology studies? |
| cord-017208-7oew461e | Is the organism currently grown in a qualified cGMP cell line? |
| cord-017208-7oew461e | Is the vector replication competent or replication defective? |
| cord-017208-7oew461e | Is there a cGMP- qualified virus seed bank? |
| cord-017208-7oew461e | Is there a danger of producing directly( as the therapeutic agent itself) or indirectly( through recombination and/or replication) an infectious agent that acts horizontally in the population or vertically across generations? |
| cord-017208-7oew461e | Is toxicity after repeated doses of agent likely to be attenuated or magnified by immunological response to the agent? |
| cord-017208-7oew461e | Some of the questions that should be answered by preclinical pharmacology/ toxicology studies are the following( 43): What is the relationship of the dose to the biologic activity? |
| cord-017208-7oew461e | Was the cell line genetically modified to support this vector? |
| cord-017208-7oew461e | What are the consequences of long- term presence of the therapeutic agent in the recipient? |
| cord-017208-7oew461e | What are to be the release criteria for the product? |
| cord-017208-7oew461e | What dose is likely to be required for therapeutic effect? |
| cord-017208-7oew461e | What is known about the product stability with respect to physical integrity and activity? |
| cord-017208-7oew461e | What is the average yield of the production system before and after purification? |
| cord-017208-7oew461e | What is the desired final product formulation? |
| cord-017208-7oew461e | What is the effect of altered tropism on anticipated host toxicity? 6. |
| cord-017208-7oew461e | What is the largest amount of material that you have produced in your laboratory in a single production batch? |
| cord-017208-7oew461e | What is the relationship of the dose to the toxicity? |
| cord-017208-7oew461e | What is the status of the product(s) regarding intellectual property issues? |
| cord-017208-7oew461e | What level of gene expression or replication is necessary to attain a therapeutic effect? |
| cord-017208-7oew461e | What risks can be identified for the clinical trial? |
| cord-017208-7oew461e | When toxicity occurs because of the agent, what is the evidence the toxicity will be reversible? |
| cord-017208-7oew461e | Who will sponsor the IND for the proposed study? |
| cord-017208-7oew461e | Why was the proposed selection chosen? |
| cord-017208-7oew461e | Would there be any utility in a genetically deficient model, and would this deficient model be more relevant to the proposed study either because of the potential for adverse immunologic consequences or because of the biological effects in the deficient condition? |
| cord-017208-7oew461e | and/or rates of reversion to either wild- type or alternate viral genomes? |
| cord-017208-7oew461e | and/or toxicity? |
| cord-004584-bcw90f5b | ( Na? dependent)[ 4]. |
| cord-004584-bcw90f5b | / H? |
| cord-004584-bcw90f5b | /H? |
| cord-004584-bcw90f5b | /H? |
| cord-004584-bcw90f5b | /H? |
| cord-004584-bcw90f5b | /H? |
| cord-004584-bcw90f5b | 4000 lmol photons m-2 s-1) have shown that fast component of ms- DF was inhibited faster with time than in case of action of Co 2? and excess light. |
| cord-004584-bcw90f5b | 7, 1518 Budapest, HungaryWide- line proton NMR FID, echoes, spin- lattice and spin- spin relaxation times were measured at 82.55 MHz frequency in the-70 ° C to? |
| cord-004584-bcw90f5b | A putative outer- membrane cytochrome, OmcF, is crucial for Fe 3? |
| cord-004584-bcw90f5b | A recent candidate for pH regulation within early endosomes and TGN is the highly conserved intracellular Na? |
| cord-004584-bcw90f5b | Acyl transfer from lipids without enzyme catalysis: a new paradigm for membrane protein ageing? |
| cord-004584-bcw90f5b | Additional studies have shown that although neither the catalytic reaction nor the establishment of the DpH requires the presence of Na?, the presence of this ion increased the proton transport. |
| cord-004584-bcw90f5b | Analyzing the fluorescence relaxation kinetics,? |
| cord-004584-bcw90f5b | Ca 2? |
| cord-004584-bcw90f5b | Ca 2? and Mn 2?, that can be attributed to their sizes and coordination properties to specific ligands. |
| cord-004584-bcw90f5b | Ca 2? and Mn 2?, that can be attributed to their sizes and coordination properties to specific ligands. |
| cord-004584-bcw90f5b | Ca?? |
| cord-004584-bcw90f5b | Ca?? |
| cord-004584-bcw90f5b | Cell migration or proliferation? |
| cord-004584-bcw90f5b | ClpB is a hexameric AAA? |
| cord-004584-bcw90f5b | Combining all these results, a model for the coupling mechanism of complex I was proposed, suggesting the presence of two different energy coupling sites, one that works only as a proton pump( Na? independent), and the other functioning as a Na? |
| cord-004584-bcw90f5b | Combining all these results, a model for the coupling mechanism of complex I was proposed, suggesting the presence of two different energy coupling sites, one that works only as a proton pump( Na? independent), and the other functioning as a Na? |
| cord-004584-bcw90f5b | Compared to these channels, the voltage- dependence of TRPA1 is very weak( apparent number of gating charges* 0.4 versus 12 in K? channels) and its putative voltage- sensing domain most likely lies outside the S4 because TRPA1 completely lacks positively charged residues in this region. |
| cord-004584-bcw90f5b | Cytoplasmic dynein moves through uncoordinated action of the AAA1 ring domains Ahmet Yildiz Department of Physics, and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 USA Cytoplasmic dynein is a homodimeric AAA? |
| cord-004584-bcw90f5b | During action on chloroplasts only of Cd 2? |
| cord-004584-bcw90f5b | Forward and reverse transport directions were investigated at zero membrane potential using preparations with inside out and right side out oriented transporters with Na? or H? |
| cord-004584-bcw90f5b | Furthermore, Na? |
| cord-004584-bcw90f5b | Generalized epilepsy with febrile seizures plus( GEFS?, OMIM 604233) is a childhood genetic epilepsy syndrome correlated to mutations in the ancillary b- subunit of neuronal voltage- gated sodium channels( NaChs). |
| cord-004584-bcw90f5b | I reduce ubiquinone, it is suggested that the Na?/H? |
| cord-004584-bcw90f5b | I reduce ubiquinone, it is suggested that the Na?/H? |
| cord-004584-bcw90f5b | In addition, our systematic and quantitative analysis( in combination with genetic modifications) provides a tool to study the role of? |
| cord-004584-bcw90f5b | In both strains the pH dependence was associated with a systematic increase of the K m for Na? |
| cord-004584-bcw90f5b | In the photosynthetic reaction center( RC) of Rhodobacter sphaeroides, fast formation of the charge separated state P? |
| cord-004584-bcw90f5b | In the present work, Al 3? induced conformational change and instant oligomerization of aS have been studied using FRET and FCS as main techniques. |
| cord-004584-bcw90f5b | In the shorter(\ 1 ms) time scale, the dominating effect is the re- reduction of the oxidized primary donor( P?? |
| cord-004584-bcw90f5b | In the shorter(\ 1 ms) time scale, the dominating effect is the re- reduction of the oxidized primary donor( P?? |
| cord-004584-bcw90f5b | Initial expression levels were determined by either partial purification using Ni 2?-NTA |
| cord-004584-bcw90f5b | It was observed that the Na? |
| cord-004584-bcw90f5b | It was observed that this bacterial complex I is able of H? |
| cord-004584-bcw90f5b | K? |
| cord-004584-bcw90f5b | Nigericin, a peptide that acts as an H?-K? |
| cord-004584-bcw90f5b | Nigericin, a peptide that acts as an H?-K? |
| cord-004584-bcw90f5b | Result indicates that damage sites of action Cd 2? |
| cord-004584-bcw90f5b | Simultaneous action of Cd 2? and photoinhibitory illumination( |
| cord-004584-bcw90f5b | Taken together with our results on the subcellular localization of the native NHE7, these unique biochemical features provide new insights on the biological function and pathological implications of this intracellular Na? |
| cord-004584-bcw90f5b | The aim of these studies was to clarify whether the specific crystalline structure of protein and protein- substrate interactions are significant for H? |
| cord-004584-bcw90f5b | The available data are restricted and only the re- oxidation of the reduced primary quinone( Q A-? |
| cord-004584-bcw90f5b | The average lifetime of donor in the presence of acceptor increases with the increase of Al 3? |
| cord-004584-bcw90f5b | The coupling ion of the system was shown to be the H? |
| cord-004584-bcw90f5b | The first and best characterized GEFS? |
| cord-004584-bcw90f5b | The intrinsic Tyr fluorescence rises sharply within the mixing dead time, reflecting an enhanced hydrophobicity of the Tyr environment and a fast conformational change of aS. Al 3? |
| cord-004584-bcw90f5b | The simultaneous effect of photoinhibitory illumination and toxic action of heavy metals ions( Cd 2? |
| cord-004584-bcw90f5b | The steadystate level at Cd 2? |
| cord-004584-bcw90f5b | The transmembrane part of the tetrameric TRPA1 is structurally related to the voltagegated K? channels in which the conserved charged residues within the fourth transmembrane region( S4) constitute part of a voltage sensor. |
| cord-004584-bcw90f5b | These data allowed to advance a transport mechanism based on competing Na? |
| cord-004584-bcw90f5b | This inner structure transmits local signals due to ATP binding and hydrolysis by AAA? domains. |
| cord-004584-bcw90f5b | This model was reinforced by further studies performed in the presence of the Na? |
| cord-004584-bcw90f5b | This work was supported by the Italian Association for Cancer Research( AIRC), the Istituto Toscano Tumori and the Associazione Noi per Voi Differential hydration, void volume: which factor provides the main contribution to DV u? |
| cord-004584-bcw90f5b | Thus, notable variations in the RNA binding specificity was observed for the divalent ions of Mg 2? |
| cord-004584-bcw90f5b | Under symmetrical Na? |
| cord-004584-bcw90f5b | Under symmetrical pH conditions with a Na? |
| cord-004584-bcw90f5b | We assume that binding site of Cd 2? is Y Z or CaMn 4-cluster, one of the recombination partners with P 680? |
| cord-004584-bcw90f5b | We assume that binding site of Cd 2? is Y Z or CaMn 4-cluster, one of the recombination partners with P 680? |
| cord-004584-bcw90f5b | We have developed somatic cell genetic techniques that enable the selection of variant cells able to resist H? |
| cord-004584-bcw90f5b | We reported previously that the increase of the cholesterol content of the cell membrane( in vitro) modified the biophysical parameters of the gating of Kvl.3 K? ion channels in human T- lymphocytes. |
| cord-004584-bcw90f5b | What makes an amyloid toxic: morphology, structure or interaction with membranes? |
| cord-004584-bcw90f5b | Whole- cell K? |
| cord-004584-bcw90f5b | and Co 2? are donor and acceptor side of PS2, accordingly. |
| cord-004584-bcw90f5b | and Co 2?) |
| cord-004584-bcw90f5b | and H? |
| cord-004584-bcw90f5b | and Na? |
| cord-004584-bcw90f5b | and U 6? reduction and also for microbial electricity production( 4). |
| cord-004584-bcw90f5b | being transported to the periplasm, contributing in this way to the establishment of the electrochemical potential difference, while Na? is translocated to the cytoplasm[ 4]. |
| cord-004584-bcw90f5b | both alkaline pH and Na? |
| cord-004584-bcw90f5b | by extracellular Ca 2? entry probably through mechanosensitive channels. |
| cord-004584-bcw90f5b | concentration, indicating aS adopts a more extended conformation upon Al 3? |
| cord-004584-bcw90f5b | hERG K? channels is associated with increased risk of arrhythmias. |
| cord-004584-bcw90f5b | killing through plasma membrane expression of H? extruders. |
| cord-004584-bcw90f5b | the fast component of ms- DF, which originates via radiative recombination of reaction center with the CaMn 4-cluster or Y Z on donor side of PS2, is inhibited stronger than at action of only Co 2?. |
| cord-004584-bcw90f5b | treatment is remain stable, while at Co 2? |