bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
ebola virus	1510
ebov gp	464
marburg virus	258
virus infection	257
virus disease	252
hemorrhagic fever	242
ebov infection	237
virus glycoprotein	174
nonhuman primates	134
type i	128
respiratory syndrome	118
vesicular stomatitis	113
dendritic cells	110
ebola hemorrhagic	107
sierra leone	105
host cell	99
stomatitis virus	97
virus entry	95
amino acid	92
public health	91
west africa	88
cell surface	88
antiviral activity	85
democratic republic	85
infected cells	84
like particles	83
immune responses	83
plasma membrane	81
viral replication	80
rna viruses	80
cell lines	80
viral load	79
syndrome coronavirus	79
immune response	78
target cells	76
guinea pigs	76
pseudotyped virus	76
viral entry	75
haemorrhagic fever	75
cell entry	74
acute respiratory	73
marburg viruses	72
zaire ebolavirus	71
infectious diseases	70
monoclonal antibodies	68
neutralizing antibodies	68
influenza virus	68
middle east	67
viral rna	66
immunodeficiency virus	66
severe acute	65
neutralizing antibody	63
filovirus infection	61
virus vp	60
evd patients	59
cord uid	58
doc id	58
filovirus entry	58
east respiratory	57
fruit bats	55
rhesus macaques	55
human immunodeficiency	54
west african	54
rna polymerase	53
binding site	53
cell types	52
previously described	52
ebov vp	52
membrane fusion	52
viral infection	52
i ifn	52
marburg hemorrhagic	52
matrix protein	51
ebov entry	51
fever virus	51
cell culture	50
virus replication	49
mg kg	48
cell fusion	48
virus infections	48
gp pseudotyped	47
low ph	46
room temperature	46
endothelial cells	46
ebola viruses	46
clinical trials	46
enveloped viruses	45
gp cl	45
cynomolgus macaques	45
effector cells	45
ebola outbreak	45
world health	45
health organization	45
host cells	43
approved drugs	43
fruit bat	42
infectious disease	41
mg ml	41
ebola haemorrhagic	41
infected patients	41
marv gp	40
united states	39
vp protein	39
monoclonal antibody	39
class i	38
cell line	38
viral proteins	38
thermo fisher	38
tetherin antagonism	37
based vaccine	37
western africa	37
animal models	36
evd outbreak	36
small molecule	35
positive cells	35
mouse model	35
virus particles	35
cellular entry	35
amino acids	35
colored fruit	35
live ebov	34
african straw	34
envelope glycoprotein	34
fisher scientific	34
described previously	34
fusion protein	34
avian influenza	34
lethal ebola	33
gene expression	33
virus transmission	33
phase i	33
case fatality	33
biosafety level	32
ebov genome	32
zaire ebola	32
virus type	32
pseudotyped hiv	32
fecal samples	32
health care	32
fatality rate	32
antibody titers	32
glycan cap	32
antibody responses	32
viral envelope	32
dendritic cell	31
nipah virus	31
genome sequences	31
stranded rna	31
ifn signaling	31
viral fusion	31
recombinant vesicular	31
dependent rna	31
clinical trial	31
huh cells	31
viral particles	31
respiratory tract	31
rna virus	30
cell epitope	30
viral genome	30
lethal challenge	30
highly pathogenic	30
host immune	30
purifying selection	30
fusion loop	30
immune system	30
pfu ml	30
equine antisera	30
may also	30
receptor binding	30
i interferon	29
innate immune	29
virus gp	29
viral infections	29
blood samples	29
life cycle	29
hela cells	29
ebov replication	29
human infection	29
npc domain	29
pseudotyped viruses	29
data sets	29
sars coronavirus	29
vaccine candidates	28
hendra virus	28
filovirus disease	28
like particle	28
gp i	28
nonhuman primate	28
ebov glycoprotein	27
based vaccines	27
bat cells	27
viral protein	27
guinea pig	27
cell responses	27
host range	27
human primates	26
cell epitopes	26
virus challenge	26
influenza viruses	26
sexual transmission	26
mucin domain	26
reporter gene	26
tnc mutations	26
dna conjugates	26
ebolavirus glycoprotein	25
antibody response	25
linked immunosorbent	25
vaccine development	25
glycoprotein gp	25
human cases	25
population coverage	25
virus glycoproteins	25
cholesterol transporter	25
rna synthesis	24
ebov infected	24
animal model	24
complete protection	24
nucleic acid	24
highly conserved	24
vaccine design	24
statistically significant	24
negative control	24
rhesus monkeys	24
viral glycoprotein	24
ebov outbreak	24
incubation period	24
proteolytic processing	24
infected animals	24
dengue virus	24
ifn system	23
fusion proteins	23
rousettus aegyptiacus	23
emerging pathogens	23
viral spread	23
electron microscopy	23
vlp entry	23
marv vp	23
binding domain	23
reverse transcription	23
cov infection	23
minigenome rna	23
soluble non	23
ng ml	23
important role	23
zaire ebov	22
protein vp	22
innate immunity	22
virus outbreak	22
human cells	22
ebov infections	22
ifitm proteins	22
lethal ebov	22
wide range	22
ebola vaccine	22
like domain	22
peptide vaccine	22
viral hemorrhagic	22
high levels	22
western blot	22
previous studies	22
protects nonhuman	22
virus neutralization	22
toremifene citrate	21
performed using	21
exporting country	21
i ifns	21
ebola viral	21
african green	21
mediated cell	21
blood ebov	21
trvlp infection	21
human transmission	21
vaccine protects	21
lassa virus	21
protein expression	21
marv infection	21
virus input	21
present study	21
well plates	21
spectrum antiviral	21
mediated fusion	21
experimentally infected	21
therapeutic agents	21
flow cytometry	21
entry requires	21
human travel	21
disease outbreaks	21
immunosorbent assay	21
prime boost	20
zika virus	20
drnpc domain	20
entry mediated	20
replication cycle	20
heptad repeat	20
tetherin expression	20
cells via	20
molecular dynamics	20
fatality rates	20
clinical signs	20
time point	20
yellow fever	20
sequence alignment	20
weight loss	20
endoplasmic reticulum	20
peripheral blood	20
myeloid cells	20
transporter niemann	20
competing interests	20
disease control	20
time points	20
risk factors	20
protective efficacy	20
cathepsin activity	20
bovine serum	20
per well	20
creative commons	20
evd survivors	20
transmembrane domain	20
small molecules	20
directional changes	19
immune evasion	19
dependent manner	19
transfected cells	19
helix bundle	19
late endosomes	19
samples collected	19
inflammatory responses	19
cleavage site	19
ebov mak	19
proinflammatory cytokines	19
encephalitis virus	19
primary human	19
emerging infectious	19
molecule inhibitors	19
based assay	19
furin cleavage	19
supplementary material	19
life technologies	19
cell viability	19
emerging viral	19
gp expression	19
luciferase reporter	19
days post	19
adaptive immune	19
family filoviridae	19
specific antibodies	19
plate reader	19
crystal structure	19
supportive care	19
branch lengths	18
infected mice	18
human ebov	18
host factors	18
natural reservoir	18
single dose	18
postexposure protection	18
plasmids encoding	18
based assays	18
passive transfer	18
cytokine dysregulation	18
results suggest	18
commonly used	18
tissue culture	18
log tcid	18
endosomal membrane	18
necrosis factor	18
type lectin	18
viral membrane	18
kcal mol	18
viral pathogens	18
tissue factor	18
rna interference	18
infection ebola	18
vaccinia virus	18
clinical features	18
fda approved	18
envelope glycoproteins	18
three times	18
like receptor	18
immune activation	18
ebov vlps	18
protein kinase	18
central africa	18
south korea	17
signaling pathways	17
neutralisation assay	17
gp subunit	17
severe disease	17
com scientificreports	17
reverse genetics	17
ebov challenge	17
pseudotyped vsv	17
nile virus	17
adverse events	17
rhesus macaque	17
secondary structure	17
significant difference	17
cleaved gp	17
structural proteins	17
ebov activity	17
positive selection	17
ebov genomes	17
human infections	17
final concentration	17
microfluidic cartridge	17
gp furin	17
cell lysates	17
ri rna	17
elevated levels	17
virus vaccine	17
plasma samples	17
west nile	17
mpxv infection	17
human survivor	17
conformational changes	17
respiratory syncytial	16
reservoir hosts	16
exposure treatment	16
ebola infection	16
virus neutralisation	16
data set	16
lassa fever	16
syncytial virus	16
cell activation	16
target cell	16
type lectins	16
gxxxg motif	16
least one	16
ebov neutralisation	16
information regarding	16
tumor necrosis	16
hemorrhagic fevers	16
reston virus	16
fusion pore	16
human macrophages	16
ic values	16
emerging viruses	16
reston ebolavirus	16
hspa motif	16
family members	16
ebov rna	16
filovirus glycoproteins	16
recombinant vsv	16
viral loads	16
cell cultures	16
envelope protein	16
lake victoria	16
human ebola	16
three areas	16
kinase inhibitors	16
mediated protection	16
green monkey	16
molecular mechanisms	15
lymphoid tissues	15
humoral immunity	15
intravascular coagulation	15
folate receptor	15
nucleocapsid proteins	15
march proteins	15
gp gene	15
rna editing	15
antigen presentation	15
restriction factor	15
extracellular vesicles	15
african outbreak	15
ebov disease	15
virus strains	15
control group	15
small animal	15
lethal infection	15
expression plasmid	15
single particle	15
equine encephalitis	15
rna genome	15
cell signaling	15
substitution rates	15
endothelial cell	15
filoviridae family	15
isg induction	15
secondary antibody	15
recent years	15
authors declare	15
binding affinity	15
virus envelope	15
plaque assay	15
previously reported	15
cells expressing	15
bodily fluids	15
neutralization assay	15
african ebola	15
ebolavirus infection	15
cysteine proteases	15
significantly higher	15
filovirus infections	15
fatal cases	15
virus vaccines	15
vero cells	15
african countries	15
neutralisation assays	15
survival rate	15
single amino	15
legal trade	15
lethal dose	15
insect cells	15
disease onset	15
entry inhibitors	15
spike protein	15
ebola treatment	14
surface protein	14
vaccine vectors	14
recombinant human	14
length gp	14
side effects	14
fetal bovine	14
ebola zaire	14
valley fever	14
inhibitors reveal	14
ebov makona	14
high degree	14
specific antibody	14
gp mrna	14
rift valley	14
goat anti	14
transcriptional editing	14
disease outbreak	14
ebov negative	14
great ape	14
saharan africa	14
glycoprotein bound	14
vectors expressing	14
internal branches	14
jui government	14
ebola epidemic	14
protective immunity	14
copies ml	14
filovirus gp	14
sudan ebola	14
infected nhps	14
even though	14
ebov igg	14
animal studies	14
reveal niemann	14
virus detection	14
serum panel	14
npc binding	14
may provide	14
virus ebola	14
mhc class	14
clinical manifestations	14
generation sequencing	14
dna vaccine	14
min ph	14
recent studies	14
fused scfv	14
tcid ml	14
vp proteins	14
recent outbreak	14
forming units	14
infection control	14
gp contains	14
buffered saline	14
body fluids	14
control antigen	13
i interferons	13
protective equipment	13
virus isolation	13
lymph nodes	13
ng pcaggs	13
host responses	13
substitution models	13
pathogenic avian	13
new world	13
acid residues	13
sequence analysis	13
experimental infection	13
three different	13
internal fusion	13
different cell	13
victoria marburgvirus	13
swab samples	13
wild type	13
whole blood	13
mammalian cells	13
rna secondary	13
multiorgan failure	13
directional change	13
human disease	13
expressing ebola	13
saudi arabia	13
entry receptor	13
evd survivor	13
causative agent	13
theraflex mb	13
inhibit ebov	13
human tetherin	13
taken together	13
determine whether	13
image analysis	13
currently available	13
endosomal proteolysis	13
culture medium	13
neutralizing activity	13
disseminated intravascular	13
inhibit ebola	13
gp proteins	13
multiple sequence	13
congo basin	13
government hospital	13
lymphocyte apoptosis	13
experimental ebola	13
secondary structures	13
human evd	13
increased risk	13
cov outbreak	13
sense rna	13
transcription factor	13
including ebov	13
expression vector	13
response curves	13
convalescent plasma	13
cellular responses	13
without vlps	13
clinical management	13
higher levels	13
epithelial cells	13
cell immunoglobulin	13
ebov virus	13
humoral immune	13
great apes	13
host proteins	13
infected individuals	12
genbank accession	12
cleaved ebov	12
nucleoside analogues	12
late endosomal	12
dromedary camels	12
particle release	12
current study	12
raw product	12
three independent	12
ph pulse	12
web server	12
virus shedding	12
abdominal pain	12
ah conditions	12
mers coronavirus	12
mortality rates	12
vaccine expressing	12
viral dissemination	12
positive control	12
human dendritic	12
serial dilutions	12
detected using	12
exposure protection	12
large number	12
virus nucleoprotein	12
egyptian fruit	12
cell membrane	12
polymerase chain	12
branch length	12
authentic ebov	12
intracellular receptor	12
healthy adults	12
thermofisher scientific	12
gfp minigenome	12
dna sequences	12
may result	12
nh cl	12
hong kong	12
measured using	12
high viral	12
confirmed cases	12
ebolavirus vp	12
dna vaccines	12
years ago	12
eu mss	12
chain reaction	12
ebola vaccines	12
surface hspa	12
mva ebov	12
plasmacytoid dendritic	12
data indicate	12
commons license	12
common marmoset	12
simian immunodeficiency	12
conformational change	12
cell immunity	12
viral glycoproteins	12
primate models	12
pick type	12
drug administration	12
also showed	12
endosomal cathepsins	12
low levels	12
post infection	12
clomiphene citrate	12
mortality rate	12
vsv pseudotypes	12
drug target	12
personal protective	12
negative serum	12
nucleic acids	12
controlled trial	12
genome replication	12
graphpad prism	12
evd outbreaks	12
venezuelan equine	12
virus nucleocapsid	12
virus titers	12
log reduction	12
i clinical	12
national institutes	12
bearing ebov	12
central african	12
fatal disease	12
cell cytoplasm	12
disease ebola	12
ebov vaccine	12
terminal heptad	12
thermolysin treatment	11
quantified using	11
recombinant adenovirus	11
post transfection	11
entry driven	11
sodium dodecyl	11
throughput screening	11
dependent enhancement	11
ebov strains	11
zaire strain	11
adapted ebov	11
clinical data	11
regulatory factor	11
one study	11
gel electrophoresis	11
mononuclear cells	11
disease progression	11
virus enters	11
coagulation abnormalities	11
surviving patients	11
phylogenetic analysis	11
broad range	11
protein interactions	11
ebov lifecycle	11
likely due	11
day post	11
cohort study	11
healthcare workers	11
enveloped virus	11
eidolon helvum	11
patients infected	11
different ebov	11
decreasing trend	11
pseudotypes bearing	11
within days	11
animal species	11
nhp model	11
transferrin receptor	11
host response	11
ebov np	11
cell layer	11
binding protein	11
disease surveillance	11
late endosome	11
polymerase cofactor	11
rate variation	11
presenting cells	11
vaccinated mice	11
hydrogen bond	11
pbs group	11
day postexposure	11
nucleoside analogs	11
convalescent patients	11
neutral ph	11
strand rna	11
protein sequences	11
antiviral activities	11
therapeutic antisera	11
postexposure prophylaxis	11
human antibody	11
using pseudotyped	11
electron tomography	11
mb light	11
iav ha	11
introduction event	11
ebov fusion	11
preliminary report	11
proposed epitope	11
virus specific	11
existing immunity	11
based ebola	11
bat species	11
virus genomes	11
sudan virus	11
cell tropism	11
advanced ebola	11
infectious virus	11
specific igg	11
expression levels	11
tnc substitutions	11
ebolavirus species	11
ebov particles	11
influenza vaccine	11
respiratory disease	11
associated proteins	11
fusion events	11
substitution model	11
encoding ebov	11
first time	11
direct contact	11
virion glycoproteins	11
error bars	11
imported case	11
national institute	11
correlation coefficients	11
nonendemic countries	11
inflammatory cytokines	11
successful treatment	11
heavily glycosylated	11
fusion pores	11
np i	11
tetherin counteraction	11
inflammatory response	11
two different	11
laboratory studies	11
adaptive immunity	11
soluble gp	11
viral life	11
lectins dc	10
serum panels	10
inhibition assay	10
igg antibody	10
host endosomal	10
recent study	10
also used	10
mev rpv	10
viral genomes	10
mouse igg	10
confirmed evd	10
binding free	10
novel coronavirus	10
kinome analysis	10
peptide arrays	10
infection resulted	10
nucleotide substitution	10
different viruses	10
strains isolated	10
acute infection	10
clinical presentation	10
high mortality	10
cytoplasmic tail	10
software package	10
independent experiments	10
molecular basis	10
expression vectors	10
functional analysis	10
egyptian rousettes	10
regression analysis	10
infected cynomolgus	10
marv entry	10
open reading	10
treated animals	10
via macropinocytosis	10
total antibody	10
also found	10
statistical analysis	10
specific cd	10
cellular immunity	10
ebov epidemic	10
cleaved form	10
contact tracing	10
viral transcription	10
rpv pprv	10
sigma adjuvant	10
medium containing	10
tetherin antagonist	10
vaccine platforms	10
ebov spread	10
luciferase signal	10
genome sequencing	10
inhibitory activity	10
sustained targets	10
cellular membranes	10
initial viral	10
cell response	10
fused scfvs	10
potential therapeutic	10
leukemia virus	10
well plate	10
inhibit filovirus	10
estrogen receptor	10
ebola outbreaks	10
acid residue	10
open access	10
repeat region	10
cell type	10
clinical observations	10
receptor niemann	10
reading frame	10
genomic surveillance	10
ctl vaccine	10
way anova	10
fusion induced	10
bundibugyo ebolavirus	10
human papillomavirus	10
confocal microscopy	10
evd cases	10
epitope prediction	10
alpha beta	10
makona variant	10
vp may	10
culture supernatant	10
virus fusion	10
global health	10
cell death	10
dce sum	10
platelet concentrates	10
patients treated	10
fever viruses	10
antiviral effects	10
therapeutic targets	10
wt mice	10
interferon response	10
reproductive tract	10
free energy	10
cellular membrane	10
vaccine efficacy	10
monkey kidney	10
infected cell	10
reading frames	10
acidic ph	10
structural basis	10
particles produced	10
ebov isolate	10
eu ms	10
genomic rna	10
treatment group	10
decay rates	10
humoral responses	10
tyrosine kinase	10
antiviral response	10
expressing ebov	10
also shown	10
significant differences	10
common features	10
gp sequences	10
standard error	10
cationic amphiphiles	10
direct effect	10
viral diseases	10
serum samples	10
statistical significance	10
virus density	10
endemic areas	10
cell receptor	10
primate model	10
cathepsin cleavage	10
antibodies directed	10
virus persistence	10
substitutions site	10
expressing cells	10
ebov proteins	10
endosomal membranes	10
host protein	10
functional characterization	9
plasma concentrations	9
activated protein	9
united kingdom	9
proteolytic cleavage	9
respiratory distress	9
horseradish peroxidase	9
ebov minigenome	9
shock protein	9
stably expressing	9
endocytic pathway	9
average number	9
converting enzyme	9
human fatal	9
early stages	9
aberrant innate	9
asymptomatic ebola	9
first months	9
virus particle	9
virus prevalence	9
mediate cellular	9
flag antibody	9
fibrin deposition	9
shed gp	9
blood transfusions	9
ebov trailer	9
mm tris	9
human macrophage	9
rapid diagnosis	9
boost vaccination	9
whether ebov	9
wild great	9
significantly reduced	9
virus matrix	9
virus origin	9
high dose	9
european union	9
total number	9
geometric mean	9
surveillance elucidates	9
dynamics simulation	9
human monocytes	9
ring vaccination	9
distinct mechanisms	9
factor viia	9
ebola patients	9
rna binding	9
ebola glycoprotein	9
natural host	9
cells treated	9
macaque model	9
chimpanzee adenovirus	9
pandemic influenza	9
ebov viral	9
ifn induction	9
disease severity	9
situation report	9
big data	9
mediated immune	9
selective estrogen	9
supplementary data	9
recombinant nematode	9
fusion mediated	9
passive immunization	9
complex formation	9
endosomal acidification	9
lineage dual	9
discovery studio	9
massive lymphocyte	9
ebov vlp	9
expression plasmids	9
ebola response	9
derived dendritic	9
symptom onset	9
viral titers	9
penicillin streptomycin	9
membrane protein	9
closely related	9
within endosomes	9
md simulations	9
filovirus family	9
aegyptiacus bats	9
may play	9
channel blocker	9
ad vaccine	9
virus proteins	9
plasmid encoding	9
gp gp	9
viral vectors	9
elisa plates	9
pbs containing	9
data analysis	9
mediated endocytosis	9
blood mononuclear	9
mayinga strain	9
therapeutic efficacy	9
important factor	9
virus infectivity	9
chikungunya virus	9
inhibitory concentration	9
filoviral entry	9
filoviral hemorrhagic	9
affected countries	9
using recombinant	9
plasma levels	9
international scientific	9
molecular weight	9
infectious agents	9
substitution rate	9
ebov trvlp	9
using different	9
takes place	9
commercially available	9
modified vaccinia	9
current outbreak	9
nucleocapsid protein	9
proinflammatory cytokine	9
recombinant ebov	9
transfection reagent	9
i fusion	9
morpholino oligomers	9
south africa	9
external solution	9
elucidates ebola	9
disease epidemiology	9
mechanical ventilation	9
antiviral immunity	9
early stage	9
vsv vectors	9
van der	9
cellular proteins	9
safety profile	9
calcium channel	9
three subtypes	9
total rna	9
fold higher	9
binding pocket	9
cellular receptors	9
mediated restriction	9
cleave ebov	9
endosomal proteases	9
cells infected	9
weeks post	9
common feature	9
metagenomic sequencing	9
deficient mice	9
binding sites	9
virus spread	9
dependent protein	9
total gp	9
receptor modulators	9
der waals	9
mpxv infections	9
critical role	9
results indicate	9
turned negative	9
ct values	9
virus genome	9
post disease	9
gp processing	9
like structures	9
poorly understood	9
viral disease	9
attenuated recombinant	9
passive microfluidic	9
emerging infections	9
neutralizing monoclonal	9
sucrose cushion	9
fever ebola	9
phage display	9
dodecyl sulfate	9
human antibodies	9
theraflex uv	9
virus load	9
live virus	9
vascular permeability	9
care workers	9
may reflect	8
virus polymerase	8
length ebov	8
tested positive	8
antibody kz	8
drug targets	8
i studies	8
virus rna	8
drug resistance	8
dependent inhibition	8
replication promoter	8
two weeks	8
needle stick	8
npc orthologs	8
ec values	8
functional antibody	8
described elsewhere	8
ebov may	8
data suggest	8
lesser extent	8
human march	8
postexposure antibody	8
antibody immobilization	8
protein sequence	8
antigenic protein	8
marburg haemorrhagic	8
regulatory approval	8
health response	8
acid changes	8
commons attribution	8
multiple cell	8
dynamics simulations	8
crystal structures	8
receptor alpha	8
ready form	8
molecular docking	8
drug discovery	8
vivo studies	8
bars indicate	8
outbreak setting	8
suspected cases	8
greatly reduced	8
ribonucleoprotein complex	8
content imaging	8
readily available	8
supplementary table	8
ill patients	8
filoviral gp	8
cell lysate	8
determined using	8
severe covid	8
log day	8
filovirus cell	8
anticoagulant protein	8
neutralizing human	8
endo lysosomal	8
selective pressure	8
therapeutic approaches	8
igy antibodies	8
one outbreak	8
monocytes macrophages	8
phase iii	8
expression system	8
acute phase	8
recovery process	8
viruses ebola	8
dcs may	8
eahy cells	8
africa ebola	8
clinical studies	8
findings suggest	8
gp protein	8
bat populations	8
treatment center	8
ebov antibody	8
experimental inoculation	8
fluorescent protein	8
cells transfected	8
sudv gp	8
bat npc	8
also observed	8
neutralising antibodies	8
graphpad software	8
viral data	8
fps sum	8
host membrane	8
renilla luciferase	8
mouse models	8
cell system	8
pathogenic viruses	8
murine leukemia	8
western african	8
heat shock	8
cellular targets	8
culture supernatants	8
african evd	8
ebov species	8
previous work	8
gp cleavage	8
technical committee	8
human monoclonal	8
protect nonhuman	8
viral haemorrhagic	8
different species	8
growth factor	8
genome sequence	8
sequence data	8
mechanisms underlying	8
kindly provided	8
nns rna	8
live animal	8
human igg	8
nitric oxide	8
antibody titres	8
similar results	8
virus surface	8
will require	8
also demonstrated	8
type calcium	8
previous study	8
molecular events	8
fatal outcome	8
chain termination	8
acid sequences	8
congo hemorrhagic	8
molecular dating	8
antibody prophylaxis	8
endosomal lysosomal	8
gene inhibition	8
gp alone	8
dimensional structure	8
provide protection	8
polyacrylamide gel	8
us department	8
clinical presentations	8
vaccine candidate	8
fatal zaire	8
given ip	8
normal distribution	8
one year	8
bats may	8
full text	8
nematode anticoagulant	8
gb virus	8
infected marmosets	8
green monkeys	8
endosomal cysteine	8
ge healthcare	8
cos cells	8
reduced ebov	8
medical countermeasures	8
animals infected	8
mem medium	8
inhibitory effect	8
highly immunogenic	8
single nucleotide	8
increasing amounts	8
green fluorescent	8
supplemental table	8
molecular mechanism	8
disease virus	8
block ebov	8
common among	8
pregnant women	8
clinical symptoms	8
seven genes	8
least two	8
iris chip	8
lymph node	8
kinome peptide	8
ebolavirus disease	8
also detected	8
higher doses	8
ebov transmission	8
forward projections	8
viia tissue	8
data presented	8
north america	8
endosomal receptor	8
npc gene	8
provides protection	8
nucleoside analogue	8
lassa viruses	8
distress syndrome	8
cells using	8
cellular cholesterol	8
another important	8
viral antigens	8
monkeypox virus	8
human populations	8
antibody prevalence	8
gp fusion	8
interferon signaling	8
interferon regulatory	8
cells stably	8
high sensitivity	8
firefly luciferase	8
genetically diverse	8
acid amplification	8
human asymptomatic	8
viral gp	8
measles virus	8
mouse anti	8
evidence suggests	8
previous reports	8
human population	7
antigen capture	7
passive immunotherapy	7
borne viruses	7
hiv gag	7
positive patients	7
ammonium sulfate	7
cho cells	7
clinically approved	7
mutation rate	7
lethal disease	7
seasonal pulses	7
potent neutralizing	7
fold serial	7
respiratory symptoms	7
response team	7
environmental conditions	7
gp residues	7
remains neutral	7
directly immobilized	7
igg responses	7
via siglec	7
two groups	7
current epidemic	7
respiratory failure	7
protein gp	7
different strategies	7
calcium channels	7
virus nonstructural	7
first immunization	7
mutant lxxxl	7
np protein	7
surface accessibility	7
host species	7
point mutations	7
recombinant vp	7
marburg agent	7
another study	7
vp interaction	7
scfv format	7
vsv particles	7
short stretches	7
cell binding	7
stomatitis viruses	7
sialic acid	7
clinical illness	7
sequencing data	7
severe sepsis	7
body weight	7
hospitalized patients	7
neutralization assays	7
proprotein convertase	7
patient viral	7
ebov infects	7
small interfering	7
test whether	7
quality control	7
protective effect	7
recombinant protein	7
important step	7
outbreak response	7
igg ebov	7
virus binding	7
enters host	7
pcr primers	7
gilead sciences	7
beta turn	7
also inhibited	7
tyro family	7
cellular immune	7
common directional	7
oral swab	7
control measures	7
ongoing outbreak	7
reactive oxygen	7
twice daily	7
dye spread	7
conserved region	7
mediated immunity	7
recently shown	7
secondary lymphoid	7
fei company	7
jurisdictional claims	7
analyses showed	7
word count	7
infectious dose	7
thank dr	7
coronavirus infection	7
directed mutagenesis	7
antiviral host	7
mm nacl	7
transmission events	7
silico docking	7
basin mpxv	7
binding energy	7
inhibitors targeting	7
mice vaccinated	7
peptide binding	7
respiratory viruses	7
rabies virus	7
vp binding	7
kda gp	7
flow cartridge	7
aids reagent	7
past outbreaks	7
supplementary file	7
inner leaflet	7
higher ah	7
features pharmacophore	7
human patients	7
interferon responses	7
standard deviations	7
human activated	7
co incubator	7
viral mutation	7
golgi apparatus	7
detection limit	7
coding regions	7
standard deviation	7
died within	7
assay using	7
cytopathic effect	7
terminal domain	7
infect cells	7
treatment regimen	7
vsv spread	7
study demonstrated	7
mice treated	7
current ebola	7
recombinant vaccine	7
acid change	7
phase trial	7
entry inhibitor	7
positive serum	7
clinical research	7
infection results	7
counteract tetherin	7
case scenario	7
specific activity	7
previously shown	7
forest virus	7
using lipofectamine	7
receiver operating	7
fatal human	7
np antibodies	7
published maps	7
go soluble	7
sign mediate	7
studies using	7
dpi survived	7
ocular fluid	7
antibody levels	7
helvum npc	7
transmission dynamics	7
may occur	7
per milliliter	7
fatal evd	7
kj mol	7
virus life	7
rabbit sera	7
purification process	7
cd cells	7
severe ebola	7
much lower	7
cynomolgus monkeys	7
clinical development	7
virus circulation	7
active metabolite	7
lipid bilayer	7
therapeutic strategies	7
human influenza	7
lower respiratory	7
human cell	7
fresh medium	7
dose vaccination	7
dependent entry	7
scoring function	7
molecular biology	7
serological assays	7
polymerase complex	7
prophylaxis protects	7
bombali virus	7
viruses using	7
broad antiviral	7
viper npc	7
filoviral infection	7
current knowledge	7
fps es	7
persistent infection	7
fusion peptide	7
macaques infected	7
metabolite deaq	7
visualized using	7
sl reference	7
reduced fusion	7
hsnpc domain	7
ebolavirus antibodies	7
increased vascular	7
intracellular compartments	7
ligand pharmacophores	7
two reading	7
five different	7
secondary cases	7
nature remains	7
ifn response	7
membrane proteins	7
three viral	7
vlp release	7
disease patients	7
use authorization	7
entry via	7
infectious ebov	7
fold dilutions	7
infection may	7
absolute humidity	7
viral shedding	7
results demonstrate	7
antiviral strategies	7
vectored vaccine	7
viruses doi	7
filovirus vaccine	7
callithrix jacchus	7
diverse marburg	7
inhibit viral	7
ifn antagonism	7
proinflammatory responses	7
vp scfvs	7
different strains	7
series changes	7
i binding	7
post onset	7
nucleoside analog	7
based vectors	7
zoonotic rna	7
viral antigen	7
infected nonhuman	7
antibody cocktail	7
chronic diseases	7
zoonotic viruses	7
molecular evidence	7
institutional affiliations	7
signal intensity	7
study team	7
past years	7
factor tetherin	7
human serum	7
previous outbreaks	7
docking simulation	7
marv replication	7
permissive cells	7
ifn responses	7
investigate whether	7
blocks ebov	7
several different	7
ebov using	7
vaccine platform	7
intensive care	7
gold standard	7
nhp models	7
wild animal	7
antiviral responses	7
will discuss	7
methylene blue	7
viral clearance	7
serological survey	7
gp subunits	7
virus growth	7
vp forms	7
acid sequence	7
based substitution	7
spillover events	7
ebov outbreaks	7
surface gp	7
deficient cell	7
ebola vp	7
expressing phage	7
control mice	7
recombinant inhibitor	7
molecule inhibitor	7
direct antiviral	7
conservancy analysis	7
accession number	7
african mpxv	7
igg antibodies	7
fatal outcomes	7
specific monoclonal	7
ebola situation	7
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loading dose	7
genetic material	7
transmission chains	7
negative regulatory	7
soluble mediators	7
barrier function	7
world arenavirus	7
restriction sites	7
reagent program	7
sense single	7
candidate vaccines	7
humans infected	7
calculated using	7
septic shock	7
lung pathogenesis	7
vaccines based	7
significantly different	7
erk mapk	7
pediatric patients	7
antiviral agents	7
induced transmembrane	7
ebov patients	7
polymerase inhibitor	7
experimental testing	7
dna spots	7
clustered together	7
virus genomic	7
viral nucleoprotein	7
gp structure	7
dsrna binding	7
transmembrane proteins	7
rnp complex	7
cells well	7
egyptian rousette	7
nucleocapsid formation	7
frequently used	7
surface proteins	7
drug screen	7
springer nature	7
specific binding	7
severe hemorrhagic	7
coiled coil	7
retinoic acid	6
force field	6
health measures	6
hypsignathus monstrosus	6
vectors encoding	6
may affect	6
luciferase assay	6
tai forest	6
interferon antagonism	6
clinical samples	6
jsrv env	6
long oligonucleotides	6
mm mgcl	6
efficient entry	6
induced cytolysis	6
bats coincide	6
evolutionary dynamics	6
genome length	6
nuclear import	6
effectively neutralized	6
either ebov	6
ebov attachment	6
mediated tetherin	6
cathepsin inhibitors	6
three human	6
phase ii	6
virus antigen	6
natural hosts	6
available data	6
also known	6
glycoprotein sgp	6
calcium phosphate	6
ebov nucleocapsid	6
mrna stability	6
chest pain	6
viral receptor	6
vlp treatment	6
small soluble	6
mutations within	6
pcr products	6
adjuvanted ebov	6
macaque models	6
wt gp	6
fluorescent assay	6
antibody produced	6
cell pairs	6
infectious pathogens	6
adjuvanted microsphere	6
bat genomes	6
human embryonic	6
male reproductive	6
expressing hafl	6
much higher	6
isothermal amplification	6
culture media	6
cholesterol clearance	6
sequence similarity	6
data collected	6
weeks later	6
adult patients	6
ebov detection	6
intramuscular injection	6
dual model	6
median age	6
virus assays	6
solved structure	6
gp binding	6
viral elements	6
stimulated genes	6
fresh growth	6
libdock scores	6
th century	6
patients may	6
expressing marv	6
one introduction	6
viral genes	6
randomized controlled	6
junin virus	6
decay rate	6
histocompatibility complex	6
mice without	6
infectious ebola	6
high level	6
homogeneous assay	6
tetherin inhibits	6
natural history	6
plasmodium falciparum	6
hla molecule	6
gp antibodies	6
expressing phages	6
antibody binding	6
epitope identification	6
may contribute	6
hydrophobic residues	6
live attenuated	6
natural human	6
combination therapy	6
human outbreaks	6
march inhibits	6
adenovirus serotype	6
prolongs survival	6
plos one	6
protect mice	6
liver enzymes	6
small glycoprotein	6
africa outbreak	6
data obtained	6
animal origin	6
two distinct	6
direct exposure	6
pore formation	6
care worker	6
phosphorodiamidate morpholino	6
macropinocytic pathway	6
human pathogens	6
glycosylated mucin	6
virus strain	6
therapy prolongs	6
multiple cationic	6
positive results	6
syndrome virus	6
nonstructural small	6
promising candidates	6
nonporous surfaces	6
march expression	6
virus families	6
hiv gp	6
virus densities	6
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induce fusion	6
sequence changes	6
cancer therapy	6
kind gift	6
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covalent modifications	6
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human clinical	6
virus vector	6
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mediated entry	6
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modulators inhibit	6
fps vdw	6
coomassie blue	6
viral persistence	6
new insights	6
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viral genomic	6
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virus sample	6
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infected humans	6
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ebov persistence	6
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structural integrity	6
conjugated secondary	6
obtained using	6
ravv ravn	6
nk cells	6
transmembrane protein	6
bacterial translocation	6
major histocompatibility	6
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ebolavirus challenge	6
peer review	6
type virus	6
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genomic replication	6
virus makona	6
precursor gp	6
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surface glycoprotein	6
clinical efficacy	6
enhance infection	6
entry pathway	6
potential targets	6
associated coronavirus	6
basic amino	6
immunosorbent assays	6
grand island	6
infection status	6
virus reduction	6
diagnostic tests	6
active form	6
genus ebolavirus	6
exporting countries	6
antigen expression	6
pig model	6
completely protects	6
ic value	6
high case	6
phylogenetic tree	6
embryonic kidney	6
bacteriophage phi	6
phase clinical	6
deleted ebov	6
ucsf chimera	6
hemorrhagic manifestations	6
recombinant ad	6
filovirus receptor	6
virus outbreaks	6
march blocks	6
akt mtor	6
fever outbreak	6
mtor signaling	6
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virus variants	6
interferon system	6
virus assembly	6
interim analysis	6
protect guinea	6
two independent	6
multivariate analyses	6
infection prevention	6
previously identified	6
vp inhibits	6
image processing	6
fda drugs	6
fresh culture	6
assay conditions	6
hyperimmune sera	6
viruses may	6
relative importance	6
research facility	6
blot analysis	6
filovirus species	6
clomiphene blocks	6
lectin specific	6
ml rvsv	6
genetic diversity	6
average virus	6
purified igg	6
cytopathic effects	6
systematic review	6
virus vectors	6
study showed	6
mediated viral	6
log pfu	6
effective antiviral	6
additional days	6
analyzed using	6
affinity chromatography	6
rnp formation	6
series word	6
infected pigs	6
also tested	6
also contribute	6
ring domain	6
molecular characterization	6
large outbreaks	6
directed expression	6
short stretch	6
epitope conservancy	6
different assays	6
luminal domain	6
approved selective	6
extracellular vesicle	6
worst case	6
specific parameters	6
pcr confirmed	6
lethal experimental	6
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endemic countries	6
total protein	6
phi may	6
convertase furin	6
fusion form	6
peptide sequence	6
postexposure treatment	6
pathogen reduction	6
among patients	6
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cell targeting	6
ebov rt	6
filovirus host	6
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entry factor	6
risk analysis	6
mediated isothermal	6
per group	6
protein data	6
biological weapons	6
animal care	6
data bank	6
pump inhibitors	6
convalescent sera	6
ifn antagonist	6
biochemical analysis	6
leone ebola	6
pick disease	6
highly lethal	6
currently circulating	6
proteases cathepsin	6
conjugated goat	6
person transmission	6
serum dilution	6
kidney cells	6
relatively high	6
conditions tested	6
life sciences	6
remains unclear	6
ebov exposure	6
antiviral drug	6
potently neutralizing	6
fold greater	6
haemorrhagic fevers	6
small nonhuman	6
mononucleotide composition	6
natural infection	6
gabonese bat	6
oxygen species	6
survival rates	6
arms races	6
pseudotype viruses	6
targeting gp	6
mean time	6
ebov variant	6
leader panhandle	6
least three	6
outbreak strain	6
protects guinea	6
newly discovered	6
endosomal pathway	6
adenovirus vectors	6
done using	6
scientificreports www	6
inducible gene	6
human survivors	6
strong inflammatory	6
screening assay	6
helical nucleocapsid	6
disease outcome	6
ph dependence	6
recent report	6
axl enhances	6
productively infected	6
lipid raft	6
coronavirus disease	6
infection via	6
ns protein	6
significantly lower	6
mutational analysis	6
sensor surface	6
posttranslational modification	6
inhibit hiv	6
activated dcs	6
protein interaction	6
vp expression	6
human npc	6
integrated research	6
bundibugyo virus	6
rna silencing	6
risk assessment	6
human mpxv	6
molecule entry	6
mediated phosphorylation	6
visible light	6
available online	6
tetherin bst	6
stabilized matrix	6
oligonucleotide composition	6
phase trials	6
verapamil inhibit	6
mediate viral	6
viruses causing	6
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another approach	6
accidental exposure	6
cocktail antibodies	6
particle formation	6
ebov igy	6
human filovirus	6
alexa fluor	6
favorable interactions	6
african fruit	6
infected rhesus	6
juvenile rousettus	6
go scfv	6
average weight	6
second luminal	6
mature dendritic	6
kinome data	6
reduce viral	6
protective monotherapy	6
vsv infection	6
laboratory animal	6
endogenous viral	6
gp shedding	6
computational analysis	6
using two	6
rna interactions	6
immunized intramuscularly	6
serum albumin	6
breast cancer	6
liver function	6
particles containing	6
immune mediators	6
virus polymerases	6
viral release	6
novel therapeutic	6
minigenome system	6
strain mayinga	6
vp blocks	6
genomic analysis	6
online version	6
infected monocytes	6
rinderpest virus	6
matrix proteins	6
breast milk	6
nucleotide variations	6
productive infection	6
convalescent blood	6
animal mortality	6
diagnostic performance	6
chronic hepatitis	6
surface glycoproteins	6
approved drug	6
employ different	6
disease symptoms	6
like phenotype	6
may lead	6
new ebola	6
pathogen inactivation	6
relative humidity	6
antibody titer	5
rna polymerases	5
shown previously	5
novel broad	5
based analyses	5
genomic sequencing	5
observational study	5
luciferase activity	5
interferon production	5
broad spectrum	5
diagnostic assays	5
dc subsets	5
vaccines protect	5
purified equine	5
protect nhps	5
antiviral factor	5
glycosylated gp	5
sera collected	5
cellular factors	5
significance level	5
ebola rna	5
evolutionary history	5
receptor activity	5
buffered formalin	5
hepatic lesions	5
antibody fails	5
efficient growth	5
coding region	5
transfection medium	5
relatively short	5
viruses replicate	5
cytotoxic effects	5
analogue bcx	5
endosomal ph	5
visit http	5
santa cruz	5
two major	5
tmrca estimates	5
ape populations	5
nucleotide changes	5
amphiphiles induce	5
multiple ebola	5
extensive intravascular	5
human anti	5
reverse transcriptase	5
tetherin restriction	5
highly glycosylated	5
lung tissue	5
sporadic outbreaks	5
many viruses	5
threshold values	5
analysis using	5
three mabs	5
cell factors	5
antigen presenting	5
may influence	5
hydrophobic interactions	5
ebov dissemination	5
asialoglycoprotein receptor	5
reservoir host	5
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virus marburg	5
ebov pathogenesis	5
early treatment	5
immune globulin	5
underlying coagulation	5
derived macrophages	5
adenovirus vector	5
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vlp injection	5
greater fusion	5
cells may	5
pathogen recognition	5
without inducing	5
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dna microarrays	5
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epitope database	5
solid substrates	5
emerging diseases	5
thermal stability	5
neutralising activity	5
pandemic potential	5
sudv outbreak	5
antiviral effectors	5
gorilla fecal	5
limited number	5
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antibody capture	5
virus protein	5
suspected evd	5
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kinase axl	5
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jac online	5
pseudoparticles bearing	5
old world	5
human primate	5
relatively small	5
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four compounds	5
clinical syndromes	5
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ddi technique	5
wild apes	5
arise independently	5
unless otherwise	5
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leader interaction	5
stick injury	5
significant inhibition	5
ion channel	5
indicated drug	5
confidence interval	5
key event	5
different times	5
san diego	5
research institute	5
one virus	5
note springer	5
linked glycosylation	5
surface expression	5
may contain	5
relative ranking	5
mediated cleavage	5
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evd pathogenesis	5
accessibility prediction	5
promote fusion	5
patient care	5
human cytomegalovirus	5
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dimethyl sulfoxide	5
np oligomerization	5
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interferon alpha	5
growth medium	5
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clinical care	5
primarily via	5
four hours	5
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gp mediates	5
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scientific reports	5
tm domains	5
sl ebov	5
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wag i	5
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cells per	5
protease inhibitors	5
index case	5
integrated density	5
marv particles	5
newly synthesized	5
trvlp system	5
core structure	5
experimentally validated	5
borne zoonotic	5
fatal ebola	5
secondary infections	5
vectored vaccines	5
thermo scientific	5
four fda	5
complete genome	5
proton pump	5
biological processes	5
blood viral	5
reduce ebov	5
enhances macropinocytosis	5
different steps	5
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mediated neutralization	5
npc ortholog	5
pcr assay	5
class ii	5
day course	5
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high concentrations	5
therapeutic oligonucleotides	5
efficacy studies	5
mva boost	5
rvsv ebola	5
fusion kinetics	5
negative septicemia	5
relative risk	5
biological samples	5
aerosol transmission	5
convalescent ebola	5
seven structural	5
baseline model	5
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lsectin interacts	5
pv assays	5
inflammatory mediators	5
virus involves	5
without vlp	5
ebola gp	5
based ebov	5
several viruses	5
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mean hospitalization	5
ongoing evd	5
control serum	5
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vp matrix	5
will need	5
viral growth	5
secretory pathway	5
antibody spots	5
protein structures	5
direct evidence	5
later stages	5
emini surface	5
upregulates siglec	5
virus survival	5
intravascular apoptosis	5
inhibitory domain	5
additional file	5
viral budding	5
ebov zaire	5
adenine analogues	5
gp interaction	5
days prior	5
multiple comparison	5
structure prediction	5
linear epitope	5
mouse antibody	5
primate monocytes	5
vsv expressing	5
filoviral gps	5
six animals	5
promotes filovirus	5
rate estimates	5
atcc crl	5
two years	5
smaller form	5
phi persisted	5
persisted longer	5
important factors	5
washed times	5
mathematical modeling	5
sudan ebov	5
studies indicate	5
side chains	5
suitable surrogate	5
nipah viruses	5
china friendship	5
subunits gp	5
fusion experiments	5
nhps survived	5
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induced disease	5
ravn virus	5
ebov trvlps	5
test values	5
antibody treatment	5
filovirus pathogenesis	5
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atcc ccl	5
health emergency	5
vlp preparations	5
based pseudotyped	5
immobilization step	5
vp virus	5
glycoproteins enhances	5
high prevalence	5
binding assays	5
concept study	5
elisa using	5
glycoprotein counteracts	5
viral nucleocapsid	5
emerging viraly	5
defective recombinant	5
disease treatment	5
ebov transduction	5
may shed	5
may indicate	5
electronic supplementary	5
tumor virus	5
egg yolk	5
arabian peninsula	5
human respiratory	5
may represent	5
safety data	5
case management	5
virtual screening	5
blood urea	5
virus decay	5
conserved among	5
naturally infected	5
reporter vlps	5
receptor npc	5
footprint similarity	5
safety concerns	5
binding buffer	5
gene assay	5
fever associated	5
rapid detection	5
final volume	5
ebov itu	5
female mice	5
hamster model	5
authorized users	5
tmprss expression	5
type mice	5
comprehensive analysis	5
absorbent pad	5
natural killer	5
randomized trials	5
collected blood	5
inactivated ebov	5
stainless steel	5
vp structure	5
complementary dna	5
liver pathology	5
experiments performed	5
work suggests	5
persistent ebov	5
feature pharmacophore	5
survival time	5
disease epidemic	5
virus amplification	5
particle vaccine	5
mobile laboratory	5
serum proteins	5
evd vaccine	5
offered protection	5
host adaptation	5
newcastle disease	5
different viral	5
virus dissemination	5
household contacts	5
ccd camera	5
test serum	5
background level	5
propensity score	5
compassionate use	5
linear regression	5
using artificial	5
may include	5
proteins inhibit	5
highly effective	5
elapsed months	5
effective treatment	5
filovirus budding	5
future work	5
unpublished essential	5
marv ci	5
ebov via	5
three species	5
vp impairs	5
geographic areas	5