bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
stem cell	1702
cell transplantation	1185
bone marrow	956
hematopoietic stem	720
median age	663
peripheral blood	650
mg kg	650
barr virus	608
overall survival	580
patients received	536
one patient	486
conditioning regimen	467
cd cells	466
chronic gvhd	456
cd cd	439
acute gvhd	431
host disease	417
multiple sclerosis	411
flow cytometry	391
nk cells	371
stem cells	369
median follow	369
median time	360
mg dl	349
allogeneic hematopoietic	338
free survival	322
design method	318
high risk	310
gvhd prophylaxis	299
risk factors	297
two patients	282
years old	271
immune response	270
significantly higher	270
case report	269
cell lines	265
pediatric patients	261
united states	251
immune system	249
statistically significant	246
viral infections	238
cord blood	228
complete remission	228
allogeneic hsct	223
unrelated donor	220
transplant recipients	219
graft failure	213
primary immunodeficiency	211
ng ml	210
allogeneic stem	209
cell transplant	203
lymph node	203
control group	201
cmv reactivation	197
myeloid leukemia	195
graft versus	195
cell lymphoma	195
cumulative incidence	194
introduction background	193
three patients	193
multiple myeloma	191
mean age	189
tumor cells	187
acute myeloid	185
increased risk	184
gene expression	182
nk cell	181
versus host	180
significant difference	177
patients receiving	175
myeloablative conditioning	174
lymph nodes	169
four patients	169
kg day	167
cell proliferation	167
old male	164
ebv infection	164
cd cell	163
retrospective study	162
immune responses	161
blood stem	161
hodgkin lymphoma	161
breast cancer	160
patients undergoing	160
exome sequencing	158
dendritic cells	156
donor chimerism	155
multivariate analysis	155
immune deficiency	153
lymphoblastic leukemia	153
grade ii	153
acute lymphoblastic	152
autologous stem	152
two groups	152
risk factor	151
class i	151
patients treated	150
hematopoietic cell	150
related mortality	149
states background	148
matched unrelated	148
university hospital	147
cd ra	146
adult patients	145
conditioning regimens	144
side effects	143
patients developed	141
grade iii	140
significant differences	140
old female	139
epithelial cells	137
immune reconstitution	137
sickle cell	137
reduced intensity	137
virus infection	134
intensity conditioning	134
combined immunodeficiency	134
five patients	134
hemophagocytic lymphohistiocytosis	133
report text	132
abstract case	132
marrow transplantation	131
year old	130
infected cells	130
adverse events	130
patients without	127
pg ml	127
months post	127
cell line	126
high dose	126
cell activation	126
protein expression	126
mononuclear cells	125
ex vivo	125
important role	124
cell receptor	123
cell source	122
acute leukemia	122
relapse mortality	121
cmv infection	121
healthy controls	121
year os	121
unrelated donors	119
immune dysregulation	119
chart review	119
significantly lower	116
neutrophil engraftment	116
cell responses	115
present study	115
differential diagnosis	115
cell carcinoma	115
patients died	113
genetic testing	113
infectious complications	113
nervous system	112
platelet engraftment	112
performed using	112
respiratory tract	111
cell disease	110
recurrent infections	110
abdominal pain	109
viral load	109
whole exome	109
disease progression	108
medical center	107
results suggest	107
acute graft	107
renal function	105
healthy donors	105
replacement therapy	105
cell count	105
disease status	104
central nervous	104
matched sibling	103
viral infection	102
lung disease	100
patient developed	100
year overall	99
median number	99
data suggest	97
clinical features	97
cell subsets	97
monoclonal antibodies	97
blood cell	96
clinical trials	96
well tolerated	96
single center	96
one year	96
autosomal recessive	96
age years	96
hematological malignancies	95
patients underwent	95
previously reported	95
significantly increased	95
least one	95
mycophenolate mofetil	95
days post	94
significantly associated	93
blood samples	93
high levels	93
bacterial infections	93
univariate analysis	92
long term	92
matched related	92
endothelial cells	92
cell dose	92
specific cd	91
clinical trial	91
six patients	91
nkt cells	91
retrospective chart	91
retrospectively analyzed	90
hsct recipients	90
cell counts	90
copies ml	89
sibling donor	89
consecutive patients	88
aplastic anemia	88
monoclonal antibody	88
infectious diseases	88
seven patients	88
platelet count	88
cell therapy	88
cell surface	88
mhc class	87
retrospective analysis	87
family history	87
infectious mononucleosis	87
statistical analysis	86
cell death	86
prospective study	85
red blood	85
herpes simplex	84
marrow failure	84
patients aged	84
autoimmune diseases	84
transcription factor	84
haploidentical donor	83
clinical presentation	83
patient died	83
first year	83
natural killer	83
patients transplanted	82
cytokine production	82
newly diagnosed	82
time points	82
cell lymphopenia	81
whole blood	81
severe combined	81
dose chemotherapy	81
complete response	81
western blot	81
statistical significance	81
median duration	80
hemophagocytic syndrome	80
aml patients	80
medical records	80
cell development	80
may also	80
time pcr	80
progressive disease	79
mast cells	79
blood cells	78
cells ul	78
eight patients	78
cells kg	78
transplant patients	78
partial response	78
plasma cells	77
patients showed	77
myelodysplastic syndrome	76
significantly reduced	76
renal failure	76
fungal infections	76
induction therapy	76
copy number	76
marrow transplant	76
grade i	76
intensive care	75
renal transplant	75
poor prognosis	75
mixed chimerism	74
nine patients	74
clinical course	74
two cases	74
response rate	74
generation sequencing	74
severe acute	74
immune suppression	74
old woman	74
cd count	73
inkt cells	73
residual disease	73
analysis showed	73
solid organ	73
ct scan	73
post transplant	73
hematologic malignancies	73
human herpesvirus	73
common variable	73
high grade	73
positive cells	73
chronic graft	72
clinical manifestations	72
th cells	72
soft tissue	72
squamous cell	72
mm patients	72
body weight	72
among patients	71
cell function	71
related donor	71
nasopharyngeal carcinoma	71
patients presented	71
determine whether	71
human immunodeficiency	71
turkey objective	71
cell depletion	71
median cd	71
innate immune	71
urinary tract	70
kidney injury	70
acute respiratory	69
granulomatous disease	69
survival rate	69
primary immune	69
informed consent	69
based conditioning	68
significant increase	68
patient received	68
ebv reactivation	68
transplant cyclophosphamide	68
mortality rate	68
cvid patients	67
immunodeficiency virus	67
immune cells	67
situ hybridization	67
immunosuppressive therapy	67
cd expression	67
cell cycle	67
patients diagnosed	67
graft rejection	67
kidney disease	67
nephrotic syndrome	67
last follow	66
active disease	66
first days	66
higher risk	66
inflammatory bowel	66
full donor	65
treatment option	65
hiv infection	65
chain reaction	65
lymphocyte subsets	65
immunoglobulin replacement	65
transplanted patients	65
significantly different	65
assay system	65
gene therapy	64
previous studies	64
disease free	64
umbilical cord	64
variable immunodeficiency	64
organ transplantation	64
one case	64
donor lymphocyte	64
survival rates	64
primary immunodeficiencies	64
relapsed refractory	64
first time	64
pediatric oncology	63
declare background	63
type i	63
growth factor	63
hemolytic anemia	63
disease relapse	63
lung cancer	63
amino acid	63
polymerase chain	63
tyrosine kinase	63
previously described	63
respiratory infections	63
allogeneic hct	63
simplex virus	62
bowel disease	62
serum levels	62
underwent hsct	62
donor type	62
analysis revealed	62
clinical data	61
cells showed	61
blood cultures	61
study period	61
transplant related	61
weight loss	61
blood mononuclear	61
patients achieved	61
lymphoproliferative disease	61
otitis media	61
young adults	61
line therapy	61
old man	60
relapse rate	60
gastrointestinal tract	60
autologous hsct	60
cell lymphomas	60
old boy	60
iv acute	60
total body	59
old girl	59
body irradiation	59
wild type	59
patient presented	59
deficient mice	59
cell depleted	59
prospective studies	59
immunocompromised patients	59
included patients	59
fungal infection	59
chronic granulomatous	59
bk virus	59
newborn screening	58
cells expressing	58
logistic regression	58
presenting cells	58
compound heterozygous	58
hsct patients	58
solid tumors	58
case series	58
marrow biopsy	58
inflammatory response	58
tract infections	58
signaling pathway	58
renal transplantation	57
next generation	57
curative treatment	57
months later	57
care unit	57
may lead	56
died due	56
ml min	56
autosomal dominant	56
diffuse large	56
autologous hematopoietic	56
specific antibodies	56
risk patients	56
expression levels	56
related complications	55
colorectal cancer	55
signaling pathways	55
salvage therapy	55
specific antibody	55
clinical symptoms	55
respiratory failure	55
haematopoietic stem	55
antibody deficiency	55
acute kidney	55
cell differentiation	55
pts received	55
prognostic factors	54
infectious disease	54
lymphoproliferative disorders	54
partial remission	54
invasive fungal	54
normal range	54
higher incidence	54
cell response	54
pid patients	54
patient population	54
extremely rare	54
two years	54
underwent allogeneic	54
risk group	54
opportunistic infections	53
gvhd grade	53
doc id	53
inclusion criteria	53
serum creatinine	53
viral dna	53
may contribute	53
antithymocyte globulin	53
physical examination	53
blood pressure	53
cord uid	53
examination revealed	53
intravenous immunoglobulin	53
underlying disease	53
clinical outcomes	53
day post	53
post hsct	53
identical sibling	53
hemorrhagic cystitis	53
organ transplant	53
minimal residual	52
results indicate	52
also found	52
diagnostic criteria	52
vod sos	52
atopic dermatitis	52
treatment options	52
supportive care	52
first case	52
lymphoproliferative disorder	52
haploidentical hsct	52
may help	52
renal biopsy	52
within months	51
patients experienced	51
plasma membrane	51
inflammatory cytokines	51
class ii	51
pediatric hematology	51
tract infection	51
high incidence	51
family members	51
lupus erythematosus	51
study group	51
adverse effects	51
early diagnosis	51
male patients	51
first line	51
developed acute	51
cell numbers	51
ten patients	51
retrospectively reviewed	50
significantly decreased	50
significant reduction	50
associated hemophagocytic	50
mouse model	50
graft function	50
prophylaxis consisted	50
national institute	50
cell types	50
antibody response	50
renal disease	50
dependent manner	50
vg vd	50
analyzed using	50
also observed	50
low dose	50
severe infections	50
medical history	50
cmv disease	50
mg day	49
two weeks	49
findings suggest	49
ebv dna	49
undergoing hsct	49
successfully treated	49
within days	49
allogeneic sct	49
study included	49
signal transduction	49
respiratory distress	49
results showed	49
clinical practice	49
phase i	49
three cases	48
cd positive	48
primary infection	48
igg levels	48
autoimmune disease	48
cell populations	48
virus replication	48
disease control	48
recent studies	48
healthy individuals	48
breast carcinoma	48
sos vod	48
haploidentical donors	48
haploidentical transplantation	48
cell population	48
childhood cancer	48
cd ro	48
term follow	48
adaptive immune	48
occlusive disease	48
systemic lupus	47
cohort study	47
retrospective review	47
relapse incidence	47
respiratory syndrome	47
cancer patients	47
per day	47
allogeneic transplantation	47
zoster virus	47
general population	47
case reports	47
myeloma patients	47
white blood	46
viral reactivation	46
older patients	46
undergoing allogeneic	46
lymphoma patients	46
iron overload	46
antigen presentation	46
th percentile	46
underwent allo	46
induction chemotherapy	46
clinical characteristics	46
progression free	46
amino acids	46
lower respiratory	46
iu ml	46
results demonstrate	46
last years	45
uric acid	45
patients engrafted	45
patient underwent	45
cytokine release	45
neutrophil count	45
stimulating factor	45
text introduction	45
surface expression	45
cell reconstitution	44
higher levels	44
skin lesions	44
cancer cells	44
increased susceptibility	44
case presentation	44
flow cytometric	44
prognostic factor	44
results show	44
line treatment	44
septic shock	44
developed grade	44
histological examination	44
data indicate	44
year survival	44
antigen presenting	44
immune cell	44
reaction norm	44
median day	44
mechanical ventilation	44
quantitative pcr	44
immunoglobulin levels	44
low levels	44
preliminary results	44
hla class	43
may play	43
increased expression	43
severe chronic	43
effective treatment	43
hla matched	43
biopsy showed	43
molecular mechanisms	43
median os	43
mrna expression	43
related donors	43
stage iii	43
treatment related	43
antibody titers	43
regression analysis	43
iv agvhd	43
secondary graft	43
malignant disease	43
year period	42
year post	42
diabetes mellitus	42
clinically significant	42
thymocyte globulin	42
median days	42
icu admission	42
membrane protein	42
low grade	42
viral replication	42
tumor cell	42
varicella zoster	42
platelet recovery	42
maintenance therapy	42
liver disease	42
two different	42
graft source	42
remaining patients	42
sinopulmonary infections	42
weight gain	42
progenitor cells	42
influenza virus	42
upper respiratory	42
major cause	42
per patient	42
prostate cancer	41
clinical outcome	41
positive patients	41
genetic correlations	41
pulmonary function	41
gene transfer	41
calcineurin inhibitors	41
missense mutation	41
antifungal prophylaxis	41
refractory disease	41
oncology patients	41
patient characteristics	41
innate immunity	41
chronic kidney	41
pediatric population	41
significantly better	41
late effects	41
examination showed	41
i molecules	41
burkitt lymphoma	40
stage i	40
patients suffering	40
health care	40
significant correlation	40
febrile neutropenia	40
fludarabine mg	40
pet ct	40
target cells	40
organ failure	40
liver biopsy	40
factors associated	40
received myeloablative	40
matched donor	40
antiviral therapy	40
hepatocellular carcinoma	40
protein levels	40
recent years	40
study aimed	40
bacterial infection	40
clinical phenotype	40
gene mutation	40
significant impact	40
center experience	40
one month	39
low cd	39
magnetic resonance	39
extensive chronic	39
overall response	39
significant association	39
tumor growth	39
hearing loss	39
macrophage activation	39
developed chronic	39
scid patients	39
positive correlation	39
cmv viremia	39
cell culture	39
developed severe	39
lymphocyte count	39
tumor necrosis	39
widely used	39
extracorporeal photopheresis	39
per year	39
recurrent respiratory	39
cd kg	39
critical role	39
necrosis factor	39
hematology oncology	39
treatment group	39
mast cell	39
sanger sequencing	39
clinical improvement	38
stable disease	38
primary graft	38
group compared	38
cell type	38
aged years	38
high level	38
liver transplantation	38
serum igg	38
average age	38
haploidentical transplant	38
animal models	38
inflammatory disease	38
spinal cord	38
confidence interval	38
sibling donors	38
infected patients	38
mismatched unrelated	38
ms risk	38
grade iv	38
three months	38
significant decrease	38
patients relapsed	38
critically ill	38
surgical resection	38
clinical response	38
liver transplant	38
patients required	38
leading cause	38
ms patients	38
treated patients	38
mesenchymal stem	38
immunohistochemical staining	37
lymphocyte infusion	37
six months	37
radiation therapy	37
transplant recipient	37
taken together	37
deficient patients	37
elderly patients	37
main cause	37
years post	37
effector cells	37
smooth muscle	37
patients compared	37
term survival	37
protective effect	37
study showed	37
agvhd grade	37
specific ctls	36
among children	36
high mortality	36
young children	36
cell mobilization	36
curative option	36
neutrophil recovery	36
may provide	36
crucial role	36
light chain	36
within hours	36
severe cgvhd	36
renal cell	36
immunosuppressive treatment	36
high rate	36
received hsct	36
combined immune	36
data show	36
three groups	36
national institutes	36
dock deficiency	36
dna repair	36
virus type	35
retrospective cohort	35
one patients	35
autoimmune cytopenias	35
yellow fever	35
thalassemia major	35
pediatric cancer	35
il rg	35
real time	35
haploidentical stem	35
epithelial cell	35
biopsy revealed	35
interstitial lung	35
absolute neutrophil	35
submission id	35
also known	35
one hundred	35
herpes virus	35
genetic analysis	35
cox regression	35
transplant lymphoproliferative	35
family donor	35
platelet counts	35
aldrich syndrome	35
first months	35
melphalan mg	35
patients may	35
electron microscopy	35
commonly used	35
potential therapeutic	35
disclosure background	35
consecutive days	35
sequencing revealed	35
serum samples	35
dendritic cell	35
cell viability	35
first month	34
initial presentation	34
two months	34
function mutations	34
ewing sarcoma	34
clinical immunology	34
stromal cells	34
broad spectrum	34
kg cd	34
female patients	34
lymphocyte infusions	34
trend towards	34
united kingdom	34
igg level	34
ebv replication	34
heterozygous mutation	34
adoptive transfer	34
current study	34
total number	34
nd allo	34
cells infused	34
elevated serum	34
oxidative stress	34
preliminary data	34
measured using	34
recurrent sinopulmonary	34
safety profile	34
heterozygous mutations	34
biological activity	34
older age	34
immune deficiencies	34
achieved cr	34
transcription factors	34
successful treatment	34
patient age	33
i ii	33
different time	33
median dose	33
cells mm	33
lymphocyte counts	33
liver enzymes	33
text background	33
following hsct	33
study population	33
latent membrane	33
human monoclonal	33
potentially curative	33
antibiotic therapy	33
rare disease	33
cgd patients	33
pathogenic variant	33
resonance imaging	33
cgvhd patients	33
well known	33
host immune	33
leukemia patients	33
even though	33
healthy control	33
may occur	33
plasma levels	33
renal allograft	33
medical university	33
atg group	33
autoimmune hemolytic	33
significantly improved	33
transplant outcomes	33
computed tomography	33
significant risk	33
liver failure	33
group patients	33
younger patients	33
effector memory	33
underwent asct	33
cancer cell	33
clinical diagnosis	33
term outcome	32
regimen consisted	32
low risk	32
lymphocyte proliferation	32
achieved complete	32
nuclear antigen	32
one week	32
thrombotic microangiopathy	32
adipose tissue	32
genomic dna	32
autologous sct	32
virus infections	32
age group	32
studies showed	32
previously healthy	32
key role	32
poor outcome	32
factor viii	32
therapeutic option	32
greece objective	32
vs days	32
significant improvement	32
transplant period	32
time period	32
well established	32
high prevalence	32
metastatic disease	32
cells per	32
solid tumor	32
tumor size	32
neutropenic fever	32
predictive value	32
neoplastic cells	32
human endogenous	32
second line	32
early onset	32
mg ml	31
three times	31
developmental delay	31
better understand	31
age groups	31
second transplant	31
nkt cell	31
reverse transcriptase	31
myeloid cells	31
low igg	31
herpes zoster	31
skin infections	31
blood transfusion	31
humoral immunity	31
cancer survivors	31
obstruction syndrome	31
respiratory syncytial	31
age range	31
kaposi sarcoma	31
colony stimulating	31
complete blood	31
function tests	31
heavy chain	31
human cd	31
pathogenic variants	31
portugal objective	31
mds patients	31
targeted therapy	31
many patients	31
specific cytotoxic	31
respiratory viruses	31
salvage chemotherapy	31
alkaline phosphatase	31
cell adhesion	31
malignant diseases	31
curative therapy	31
twice daily	31
switched memory	31
eligible patients	31
cell membrane	31
apoptotic cells	31
cell carcinomas	31
first day	31
significant morbidity	31
may represent	30
associated herpesvirus	30
red cell	30
antibody levels	30
cell growth	30
microscopic examination	30
patient group	30
acute chest	30
igg mg	30
eleven patients	30
large cell	30
complete resolution	30
staphylococcus aureus	30
refractory acute	30
patients affected	30
adaptive immunity	30
latent infection	30
high frequency	30
better os	30
male patient	30
spindle cells	30
severe aplastic	30
human cytomegalovirus	30
neutralizing antibodies	30
rheumatoid arthritis	30
showed normal	30
small cell	30
response rates	30
trial registry	30
lung tissue	30
animal model	30
expression level	30
years ago	30
intermediate risk	30
cells mcl	30
common cause	30
mouse models	30
binding site	30
reactive protein	30
within normal	30
case highlights	30
patient showed	30
immunodeficiency diseases	30
molecular weight	30
following allogeneic	30
spindle cell	29
laboratory data	29
small number	29
hct recipients	29
therapeutic strategy	29
iga nephropathy	29
steroid refractory	29
affected patients	29
significantly correlated	29
blood transplantation	29
wound healing	29
antibody responses	29
without significant	29
remains unclear	29
nitric oxide	29
chest syndrome	29
primary human	29
clinical findings	29
nucleic acid	29
may result	29
received allo	29
sinusoidal obstruction	29
cells may	29
cell products	29
cell tumors	29
side effect	29
release syndrome	29
gold standard	29
risk acute	29
decision making	29
dna levels	29
laboratory findings	29
humoral immune	29
sample size	29
using flow	29
female patient	29
treatment strategies	29
antiviral activity	29
haemophagocytic syndrome	29
syncytial virus	29
prognostic significance	29
bronchoalveolar lavage	29
allogeneic transplant	28
first report	28
nocturnal enuresis	28
also showed	28
stage ii	28
immune evaluation	28
conventional chemotherapy	28
cd lymphocytes	28
future studies	28
ulcerative colitis	28
wilms tumor	28
antigen processing	28
standard treatment	28
showed significant	28
cd depleted	28
pulmonary fibrosis	28
transgenic mice	28
first patient	28
lung transplantation	28
electronic medical	28
lamina propria	28
ataxia telangiectasia	28
cell survival	28
memory cells	28
severe neutropenia	28
brain tumors	28
gestational age	28
per week	28
pik cd	28
authors declare	28
ebv genome	28
plasma cell	28
normal levels	28
like receptor	28
patients included	28
cell recovery	28
cellular immunity	28
urinary bladder	28
control study	28
alpha beta	28
single centre	28
published data	28
research funding	28
pediatric patient	28
inborn errors	28
better understanding	28
salvage treatment	28
mg daily	28
zu einer	28
term outcomes	28
healthy subjects	28
uncertain significance	28
jazz pharmaceuticals	28
antifungal therapy	28
engraftment occurred	28
blood count	28
proinflammatory cytokines	28
single cell	27
performance status	27
early detection	27
cerebrospinal fluid	27
acute phase	27
infected individuals	27
young adult	27
genes involved	27
cell number	27
mycobacterium tuberculosis	27
like receptors	27
may affect	27
virus associated	27
early post	27
antigen receptor	27
physical exam	27
time point	27
dc leu	27
acute rejection	27
chemotherapy alone	27
adoptive immunotherapy	27
every weeks	27
cell immunity	27
scoring system	27
month old	27
patient cohort	27
often associated	27
still alive	27
determined using	27
stage renal	27
disease severity	27
median survival	27
entire cohort	27
leukemia cells	27
identify patients	27
unknown significance	27
immunohistochemical analysis	27
inflammatory cytokine	27
chemotherapy followed	27
genetic diagnosis	27
blood culture	27
gvhd occurred	27
brain mri	27
related toxicity	27
serum ferritin	27
hek cells	27
recurrent pneumonia	27
kinase inhibitor	27
febrile episodes	27
life threatening	27
will help	27
disease activity	27
heart disease	27
chimeric antigen	27
central venous	27
cyclophosphamide mg	27
related disease	27
increased frequency	27
rank test	27
infectious agents	27
low incidence	27
dna replication	27
preparative regimen	26
study suggests	26
chronic myeloid	26
renal tubular	26
environmental factors	26
medical record	26
dna load	26
event free	26
organ damage	26
stat gof	26
producing cells	26
negative control	26
studies revealed	26
days later	26
central role	26
disease caused	26
node metastasis	26
retrospectively evaluated	26
year cumulative	26
different types	26
van het	26
gata deficiency	26
autologous transplantation	26
homozygous mutation	26
surgical excision	26
nucleated cells	26
tumour cells	26
limited data	26
blood vessels	26
several studies	26
study shows	26
kidney transplantation	26
normal controls	26
university medical	26
post hct	26
twelve patients	26
liver function	26
intensive chemotherapy	26
hla identical	26
cell replete	26
regression model	26
old caucasian	26
cd dose	26
reported cases	26
haploidentical hematopoietic	26
causative agent	26
children undergoing	26
patients responded	26
cells infected	26
lymphocytic leukemia	26
dna binding	26
early childhood	26
risk stratification	26
salivary gland	26
therapeutic strategies	26
natural history	26
lymphoblastoid cell	26
infused cd	26
hospital stay	26
beam group	26
allogeneic haematopoietic	26
growth factors	26
literature review	26
female ratio	26
advanced disease	26
per kg	26
immunosuppressive drugs	26
allogeneic bone	25
reactive oxygen	25
donor age	25
dose steroids	25
preemptive therapy	25
may cause	25
higher rate	25
unrelated cord	25
chronic renal	25
negative patients	25
results obtained	25
western blotting	25
specific igg	25
data demonstrate	25
pulmonary disease	25
spectrum antibiotics	25
post asct	25
alternative donor	25
promising results	25
oxygen species	25
poorly understood	25
parenteral nutrition	25
primary endpoint	25
cardiovascular disease	25
paraffin embedded	25
posttransplant lymphoproliferative	25
cell repertoire	25
treatment failure	25
severe gvhd	25
large cohort	25
analyzed patients	25
intestinal gvhd	25
model group	25
highly conserved	25
blood counts	25
without evidence	25
steroid therapy	25
wide range	25
new york	25
urothelial carcinoma	25
multicenter study	25
assessed using	25
patient experienced	25
mean number	25
lung biopsy	25
fold increase	25
igg positive	25
plasmodium falciparum	25
cd ratio	25
granulocyte colony	25
healthy donor	25
clinical signs	25
primary tumor	25
rare case	25
phase ii	25
interferon gamma	25
mean time	25
gastric cancer	25
somatic mutations	25
receptor excision	25
viral proteins	25
three years	25
new therapeutic	25
female presented	25
treatment modality	25
less likely	25
calculated using	25
control groups	25
immunohistochemical expression	25
left ventricular	25
donor source	25
hazard ratio	25
exact test	25
post transplantation	25
skin biopsy	25
identified patients	24
days vs	24
possible role	24
prrs outbreak	24
patients years	24
cytokine levels	24
therapeutic options	24
advanced stage	24
protein kinase	24
inhibitory effect	24
high rates	24
also significantly	24
immunosuppressive agents	24
chronic lung	24
binding protein	24
synovial sarcoma	24
viral hepatitis	24
observational study	24
bis zu	24
body mass	24
type diabetes	24
steroid treatment	24
healthy children	24
cellular immune	24
chronic inflammatory	24
small molecule	24
paediatric patients	24
czech republic	24
host cells	24
invasive aspergillosis	24
evans syndrome	24
showed significantly	24
acute renal	24
blood donors	24
comorbidity index	24
ae ae	24
transplant complications	24
ct scans	24
prophylactic antibiotics	24
birth weight	24
fusion protein	24
combination therapy	24
mri showed	24
revealed normal	24
genetic evaluation	24
cell compartment	24
rag deficiency	24
groups according	24
cancer center	24
induced apoptosis	24
haematological malignancies	24
lymphoproliferative syndrome	24
vascular malformations	24
heterogeneous group	24
hematopoietic cells	24
cell subset	24
descriptive statistics	24
adhesion molecules	24
clinical studies	24
patients met	24
better survival	24
studies suggest	24
peripheral stem	24
lymphoma cells	24
myeloid malignancies	24
colon cancer	24
lower incidence	24
western blots	24
respiratory symptoms	24
hies patients	24
young patients	24
mantle cell	23
similar results	23
fully matched	23
specific immune	23
severe sepsis	23
node biopsy	23
platelet transfusions	23
relapse free	23
inflammatory responses	23
streptococcus pneumoniae	23
brazil objective	23
relapsed disease	23
hsct using	23
previously published	23
independent prognostic	23
ko mice	23
data regarding	23
based regimen	23
severe disease	23
dominant negative	23
leukemic cells	23
kommt es	23
clinical parameters	23
targeted therapies	23
portal hypertension	23
average number	23
average time	23
lower risk	23
functional studies	23
already published	23
thyroid carcinoma	23
salivary glands	23
family donors	23
longer follow	23
cik cells	23
immune globulin	23
improved survival	23
baseline characteristics	23
genetic correlation	23
donor cells	23
latently infected	23
gene mutations	23
relapsed aml	23
malignant cells	23
median interval	23
organ dysfunction	23
single dose	23
th cytokines	23
cancer therapy	23
male presented	23
differentially expressed	23
spain objective	23
clinical significance	23
dna polymerase	23
renal impairment	23
patients will	23
positively correlated	23
first reported	23
overall mortality	23
lung transplant	23
abstract already	23
serious adverse	23
marginal zone	23
refractory agvhd	23
tumor suppressor	23
independently associated	23
evaluation revealed	23
stat phosphorylation	23
viral genome	23
patients reported	23
significantly elevated	23
endogenous retrovirus	23
clinical management	23
icu mortality	23
viral antigens	23
conditioning therapy	23
poor mobilizers	23
gi tract	23
scan showed	23
clinical background	23
ecp treatment	23
mitotic activity	23
first complete	23
antibody production	22
reduced toxicity	22
different clinical	22
ige syndrome	22
high morbidity	22
pediatric hsct	22
human genome	22
plasma samples	22
common complication	22
nucleic acids	22
russia objective	22
cumulative incidences	22
molecular basis	22
measles virus	22
undergoing allo	22
linear regression	22
received chemotherapy	22
mass spectrometry	22
meier method	22
virus reactivation	22
cells within	22
antigen specific	22
mutation analysis	22
biopsy specimens	22
trough levels	22
study aims	22
neutralizing activity	22
cells ml	22
patients following	22
actin cytoskeleton	22
th day	22
autoimmune disorders	22
tlr ligands	22
germinal center	22
cells expressed	22
clinical presentations	22
allogenic hematopoietic	22
compared using	22
primary tumors	22
higher expression	22
mass index	22
disease burden	22
previously shown	22
disease onset	22
cell lung	22
large number	22
clear cell	22
immune recovery	22
novel mutation	22
cytomegalovirus infection	22
vast majority	22
ric regimen	22
igg antibodies	22
evaluable patients	22
initial evaluation	22
laboratory evaluation	22
gene products	22
graft survival	22
severe complication	22
cell collection	22
short stature	22
cell tumor	22
chronic lymphocytic	22
tumor progression	22
cells using	22
studies show	22
initially presented	22
genetic defect	22
years later	22
infected mice	22
urinary protein	22
antibiotic treatment	22
pain control	22
poor graft	22
cd monoclonal	22
cmv dna	22
histopathological examination	21
complement activation	21
allograft recipients	21
public health	21
brentuximab vedotin	21
iv antibiotics	21
conditioned patients	21
graft vs	21
inflammatory diseases	21
median overall	21
frequently used	21
germany objective	21
epstein barr	21
cell maturation	21
cell infusion	21
functional assays	21
abstract withdrawn	21
virus dna	21
human peripheral	21
data collection	21
testing revealed	21
transplant outcome	21
data collected	21
newborn screen	21
sectional study	21
treatment modalities	21
absolute lymphocyte	21
nutritional status	21
linked cgd	21
splice site	21
disorder characterized	21
showed diffuse	21
cd antibody	21
primary disease	21
high expression	21
pilot study	21
second patient	21
showed high	21
cardiac surgery	21
times per	21
serum immunoglobulin	21
early relapse	21
iron deficiency	21
histological features	21
multivariable analysis	21
immune activation	21
severe thrombocytopenia	21
threatening complication	21
first dose	21
lung function	21
cell immune	21
influenza viruses	21
mrd group	21
breast carcinomas	21
major role	21
iii iv	21
csf group	21
low level	21
likely pathogenic	21
higher cd	21
expression profile	21
differential expression	21
distress syndrome	21
serum level	21
breast milk	21
kidney transplant	21
children treated	21
higher rates	21
pediatric renal	21
single agent	21
remission status	21
risk cytogenetics	21
month post	21
transplant centers	21
thymic epithelial	21
serious complication	21
blot analysis	21
agvhd patients	21
antibiotic prophylaxis	21
type ii	21
stranded rna	21
least months	21
extracellular matrix	21
dose melphalan	21
cells compared	21
mhc i	21
showed severe	21
marrow aspirate	21
rna interference	21
gi agvhd	21
mutant mice	21
cell expansion	21
early death	21
prognostic value	21
respiratory virus	21
male female	21
year follow	21
disease risk	21
pediatric nephrology	21
single institution	21
total cd	21
negative selection	21
therapeutic targets	21
previous reports	21
early mortality	21
first years	21
national university	21
lower gi	21
received allogeneic	21
selected patients	21
kg bw	21
human leukocyte	21
healthy volunteers	21
reported case	20
high index	20
pts died	20
absolute number	20
engraftment failure	20
clinical phenotypes	20
cd depletion	20
case description	20
thrombocytopenic purpura	20
received rituximab	20
laboratory studies	20
clinical study	20
post allo	20
cells obtained	20
gastric carcinoma	20
good response	20
mutational status	20
cytokine secretion	20
young age	20
peritoneal dialysis	20
closely related	20
patients submitted	20
treg cells	20
complete donor	20
heart transplant	20
treatment response	20
center study	20
cytogenetic risk	20
statistically different	20
medical sciences	20
mobilized peripheral	20
renal involvement	20
chronic inflammation	20
met een	20
cells transplantation	20
type mice	20
mechanisms underlying	20
lower levels	20
hematopoetic stem	20
sixteen patients	20
likely due	20
patients presenting	20
high resolution	20
sle patients	20
data suggests	20
better outcome	20
disease course	20
transplant characteristics	20
four years	20
lymphoid cells	20
papillary thyroid	20
porcine reproductive	20
cell transplants	20
avian influenza	20
past medical	20
statistical difference	20
ill patients	20
mononuclear cell	20
bl mice	20
intraepithelial neoplasia	20
corticosteroid therapy	20
patients admitted	20
chronic diarrhea	20
adverse reactions	20
bal samples	20
early stages	20
initial diagnosis	20
two days	20
therapeutic approach	20
cox proportional	20
remained stable	20
immunodeficiency disease	20
cell lysates	20
china objective	20
viral particles	20
gastrointestinal symptoms	20
recent study	20
mrd negative	20
north america	20
relapse risk	20
heart failure	20
cystic fibrosis	20
based regimens	20
nonrelapse mortality	20
systemic treatment	20
evaluation showed	20
iran objective	20
drug interactions	20
elevated ige	20
antimicrobial therapy	20
target genes	20
one episode	20
related infections	20
gata mutation	20
cell cultures	20
von willebrand	20
independent risk	20
end point	20
immunohistochemical study	20
lof stat	20
based gvhd	20
dengue virus	20
three pts	20
arterial hypertension	20
absolute cd	20
scd patients	20
gene amplification	20
group vs	20
patient samples	20
risk disease	20
immune status	20
syndrome virus	20
study demonstrates	20
romania objective	20
clinical history	20
except one	20
remains controversial	20
malignant transformation	20
adverse event	20
increased incidence	20
patients also	20
gene encoding	20
data obtained	20
ebv pcr	20
elevated levels	20
regulatory cells	20
cell mediated	20
cd car	19
linked agammaglobulinemia	19
pathogenic mutation	19
induction treatment	19
factor receptor	19
cancer diagnosis	19
aspergillus fumigatus	19
patients develop	19
heterozygous missense	19
cases showed	19
described previously	19
fourteen patients	19
enzyme replacement	19
also performed	19
kg per	19
acid levels	19
acute infection	19
tumor grade	19
among individuals	19
ferritin levels	19
may serve	19
graft loss	19
short course	19
receptor expression	19
lymphocyte subpopulations	19
alive without	19
severe anemia	19
mycobacterial infections	19
clinically relevant	19
autologous hct	19
cd foxp	19
kinase inhibitors	19
connective tissue	19
immune function	19
hsct setting	19
het virus	19
inflammatory cells	19
cellular therapy	19
treatment strategy	19
ebv viral	19
vaccinia virus	19
absolute counts	19
potential role	19
immunodeficiency syndrome	19
risk neuroblastoma	19
phase study	19
transgene expression	19
plerixafor group	19
ebv transformation	19
lymphocyte subset	19
quality control	19
proteins involved	19
cell sources	19
cell epitopes	19
survival analysis	19
well documented	19
mud mmud	19
vitro studies	19
effective therapy	19
report two	19
worse prognosis	19
children aged	19
cd levels	19
may benefit	19
recombinant human	19
immune tolerance	19
recurrent bacterial	19
relapse rates	19
five cases	19
complete chimerism	19
cases reported	19
risk aml	19
specific treatment	19
patients using	19
weeks later	19
developed cmv	19
familial hemophagocytic	19
patient care	19
full length	19
enrolled patients	19
definitive diagnosis	19
results support	19
received dli	19
needle biopsy	19
gvhd patients	19
old patient	19
risk features	19
also reported	19
every months	19
primary cutaneous	19
cells play	19
genetic alterations	19
well described	19
four cases	19
frequently associated	19
central memory	19
donor cell	19
mainly due	19
total rna	19
specific anti	19
novel therapeutic	19
life cycle	19
blood transplant	19
lentiviral vector	19
autoimmune lymphoproliferative	19
elevated liver	19
commercially available	19
primary ebv	19
unknown origin	19
bronchiolitis obliterans	19
research center	19
antibody deficiencies	19
blood volume	19
patient groups	19
hematological recovery	19
higher frequency	19
seasonal influenza	19
severe complications	19
health status	19
reference range	19
may improve	19
active infection	19
blood flow	19
done using	19
tertiary care	19
host defense	18
human herpes	18
data support	18
ada deficiency	18
revealed low	18
crispr cas	18
red cross	18
immune evasion	18
relatively low	18
serum immunoglobulins	18
immunodeficiency disorders	18
viral mirnas	18
phox cgd	18
ebv transformed	18
phage library	18
months old	18
pediatric transplant	18
primary outcome	18
cd counts	18
fanconi anemia	18
post sct	18
cells express	18
laboratory parameters	18
mediated immunity	18
cell sorting	18
rna sequencing	18
stat mutations	18
dna methylation	18
may explain	18
caucasian male	18
pts receiving	18
following hematopoietic	18
chronic infection	18
ccr expression	18
gi gvhd	18
mrna levels	18
investigate whether	18
alternative donors	18
evaluated using	18
multivariate analyses	18
apoptotic cell	18
function mutation	18
mg twice	18
rare autosomal	18
double negative	18
underwent haplo	18
endothelial cell	18
allergy immunology	18
pneumocystis jirovecii	18
recently described	18
cases diagnosed	18
developed agvhd	18
day survival	18
first described	18
log rank	18
node metastases	18
skin rash	18
respiratory infection	18
sh domain	18
significant changes	18
liver toxicity	18
emergency department	18
allogenic hsct	18
index patient	18
randomly selected	18
therapeutic target	18
ra cd	18
study provides	18
also included	18
inflammatory markers	18
also detected	18
virus latent	18
tissue microarray	18
heavily pretreated	18
consanguineous parents	18
hospital universitario	18
excision circles	18
clinical picture	18
standard therapy	18
years overall	18
four weeks	18
early recognition	18
liposomal amphotericin	18
candida albicans	18
pediatric intensive	18
human papillomavirus	18
multiorgan failure	18
malignant tumors	18
donor lymphocytes	18
chemotherapeutic agents	18
using elisa	18
surviving patients	18
raji cells	18
previously treated	18
rare complication	18
mice showed	18
twenty patients	18
rare tumor	18
frequent complication	18
risk groups	18
molecular analysis	18
collected data	18
pleural effusion	18
ebv viremia	18
highly active	18
normal control	18
time quantitative	18
calcineurin inhibitor	18
kg body	18
norm model	18
also received	18
axillary lymph	18
adv infection	18
total dose	18
patients whose	18
transfected cells	18
mental status	18
renal injury	18
also present	18
younger age	18
flow cytometer	18
platelet aggregation	18
treated mice	18
additional patients	18
may influence	18
room temperature	18
hospital medical	18
oncology group	18
congenital heart	18
recurrent skin	18
higher number	18
data analysis	18
adhesion molecule	18
immunological synapse	18
trec levels	18
risk score	18
institutional review	18
activation syndrome	18
relatively high	18
malignant melanoma	18
threatening complications	18
endogenous retroviruses	18
systematic review	18
several years	18
prognostic impact	18
largely unknown	18
protein level	17
remains unknown	17
least two	17
patients suffered	17
different stages	17
correlation coefficient	17
donor transplant	17
cell cytotoxicity	17
received peripheral	17
cervical lymphadenopathy	17
close monitoring	17
times daily	17
culture system	17
os rates	17
cancer treatment	17
cell transplantations	17
elevated igg	17
low iga	17
recessive disorder	17
subsequently developed	17
posttransplant cyclophosphamide	17
fusion proteins	17
showed complete	17
italy objective	17
world health	17
treatment groups	17
pivotal role	17
first two	17
steady state	17
second hsct	17
lower extremity	17
myeloid leukaemia	17
four months	17
immunologic evaluation	17
patients present	17
haploidentical family	17
ige levels	17
pulmonary infection	17
effector functions	17
myelomonocytic leukemia	17
transplant candidates	17
whereas patients	17
cytomegalovirus reactivation	17
larger cohort	17
mechanisms involved	17
acquired immunodeficiency	17
refractory gvhd	17
transplantation cyclophosphamide	17
adenovirus infection	17
infection associated	17
invasive breast	17
limited number	17
beta thalassemia	17
increased significantly	17
reactivation occurred	17
major complication	17
significant proportion	17
light microscopy	17
sequence analysis	17
oral mucositis	17
germ cell	17
retrospectively analysed	17
strongly associated	17
neutropenic patients	17
recently identified	17
live vaccines	17
cytokine response	17
host cell	17
helper cells	17
wbc count	17
vascular endothelial	17
kir dl	17
complex karyotype	17
highly expressed	17
classified according	17
ductal carcinoma	17
unmanipulated haploidentical	17
activated cd	17
term survivors	17
protective immunity	17
signet ring	17
growth hormone	17
tumor development	17
molecular diagnosis	17
fold higher	17
glomerular filtration	17
hodgkin lymphomas	17
cell clones	17
poor outcomes	17
therapy may	17
without gvhd	17
die diagnose	17
gene rearrangement	17
ctla ig	17
extracellular vesicles	17
positive plasma	17
antiviral agents	17
sore throat	17
cd memory	17
mcg kg	17
morpholino oligomers	17
patient survival	17
negative bacteria	17
blood cd	17
past years	17
two children	17
aml mds	17
allo hsct	17
multivariate cox	17
autoimmune manifestations	17
antiviral drugs	17
recurrent episodes	17
ec ii	17
surgical specimens	17
low doses	17
hematological diseases	17
considered statistically	17
lipid rafts	17
intracellular cytokine	17
cancer institute	17
mortality rates	17
year later	17
lytic cycle	17
dose therapy	17
located within	17
nadph oxidase	17
ebv infectivity	17
good partial	17
well circumscribed	17
two pts	17
clinical manifestation	17
globin gene	17
cell grafts	17
carcinoma cells	17
novel agents	17
investigated whether	17
igm levels	17
infection may	17
gvhd incidence	17
phage display	17
lymphoid organs	17
three different	17
confocal microscopy	17
sct group	17
increased levels	17
autologous peripheral	17
quantitative real	17
irb approval	17
systemic steroids	17
positive blood	17
surface markers	17
serum albumin	17
received bone	17
cytotoxic activity	17
donor hsct	17
net state	17
two cohorts	17
using standard	16
group received	16
blood transfusions	16
month period	16
different cell	16
hla antibodies	16
binding domain	16
hsct performed	16
activation markers	16
developing countries	16
copy numbers	16
responded well	16
igm mg	16
treatment regimens	16
laboratory tests	16
using spss	16
cells stimulated	16
cells also	16
dna damage	16
early stage	16
gram negative	16
philadelphia chromosome	16
day mortality	16
hla typing	16
myelodysplastic syndromes	16
survivin expression	16
major severe	16
high doses	16
six weeks	16
embedded tissue	16
ctla haploinsufficiency	16
prophylaxis regimens	16
vgamma vdelta	16
frequently observed	16
small bowel	16
dose cyclophosphamide	16
positive cases	16
organ toxicity	16
one day	16
complement pathway	16
financial support	16
days prior	16
larger studies	16
fas ligand	16
fully understood	16
regression models	16
cell histiocytosis	16
pidd patients	16
small sample	16
grade vur	16
haploidentical transplants	16
bei kindern	16
last decade	16
lymphocytic interstitial	16
mean value	16
square test	16
phase iii	16
normal limits	16
segmental glomerulosclerosis	16
growth pattern	16
platelet transfusion	16
based therapy	16
leukocyte antigen	16
brain injury	16
genetic defects	16
cytokine profile	16
late onset	16
useful tool	16
hematology department	16
immediate early	16
toxicity profile	16
oral cavity	16
treatment lines	16
vaccine responses	16
histological type	16
syndrome associated	16
primary refractory	16
consecutive adult	16
three weeks	16
may reflect	16
like phenotype	16
one child	16
otherwise healthy	16
wt mice	16
showed increased	16
matched healthy	16
rabbit atg	16
related toxicities	16
clostridium difficile	16
lytic replication	16
cd neg	16
langerhans cell	16
acute otitis	16
cik cell	16
celiac disease	16
reproductive performance	16
systemic inflammation	16
inhibitory effects	16
frequent cause	16
histological grade	16
effector function	16
cell activity	16
early phase	16
one died	16
cytometric analysis	16
quantitative analysis	16
potential risk	16
dilating vur	16
metastatic potential	16
human disease	16
survival outcomes	16
clinimacs prodigy	16
distant metastases	16
hematopoietic recovery	16
derived dendritic	16
treated cells	16
health organization	16
igg trough	16
respiratory viral	16
odds ratio	16
patient also	16
thirteen patients	16
cells transfected	16
also associated	16
longer time	16
ml kg	16
diagnostic tool	16
severe hemophilia	16
received mg	16
clinical research	16
single nucleotide	16
chest ct	16
review board	16
sequential conditioning	16
posttransplant period	16
systemic disease	16
less severe	16
luciferase reporter	16
results confirm	16
surgical treatment	16
csa treatment	16
patients characteristics	16
effective therapeutic	16
case study	16
also analyzed	16
extremely low	16
bleeding episodes	16
childrens hospital	16
systemic corticosteroids	16
health outcomes	16
influenza vaccine	16
marrow derived	16
allowed us	16
exclusion criteria	16
disease associated	16
analysis using	16
group showed	16
fluid overload	16
improve outcomes	16
low rates	16
antimicrobial agents	16
recipient cells	16
specific ctl	16
mice compared	16
synovial sarcomas	16
imaging showed	16
pbsc grafts	16
plasma exchange	16
included children	16
using anti	16
international prognostic	16
infection risk	16
recipient weight	16
immunology clinic	16
depleted haploidentical	16
patients remain	16
high serum	16
unclear whether	16
first hours	16
lower extremities	16
received either	16
retrospectively collected	16
enzymatic activity	16
hematologic diseases	16
myelogenous leukemia	16
month follow	16
donor recipient	16
risk mds	16
physical functioning	16
one third	16
medical faculty	16
including patients	16
facs analysis	16
negative impact	16
transplantation unit	16
oxidative burst	16
interstitial fibrosis	16
initially treated	16
cell transformation	16
cell doses	16
previously unreported	16
oral ulcers	16
pseudomonas aeruginosa	16
significantly shorter	15
severe congenital	15
without agvhd	15
ecp procedures	15
disease manifestations	15
pleural effusions	15
ucsf benioff	15
two doses	15
six cases	15
negative correlation	15
recombinant factor	15
formalin fixed	15
genetic disorder	15
retrospectively studied	15
classical hodgkin	15
may require	15
idiopathic pulmonary	15
helicobacter pylori	15
skin abscesses	15
commonly associated	15
schonlein purpura	15
gastrointestinal stromal	15
severe infection	15
strong correlation	15
several months	15
induction regimens	15
urine ngal	15
nhl patients	15
also seen	15
renal insufficiency	15
immune escape	15
allogenic stem	15
duffy null	15
thyroid cancer	15
ui ml	15
physical therapy	15
prospective trials	15