This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.
| identifier | question |
|---|---|
| cord-007261-b5fgb9wf | reticulum Iscytochrome P-450 transported from the endoplasmic reticulum to the Golgi apparatus in rat hepatocytes? |
| cord-017866-h5ttoo0z | Multiple trimeric G- proteins on the trans- Golgi network exert stimulatory and inhibitory effects on secretory vesicle formation T rimeric G- proteins of the trans- Golgi network are involved in the formation of constitutive secretory vesicles and immature secretory granules Formation of nascent secretory vesicles from the trans- Golgi network of endocrine cells is inhibited by tytosine kinase and phosphatase inhibitors Cooperativity of phosphatidylinositol transfer protein and phospholipase D in secretory vesicle formation from the TGN- phosphoinositides as a common denominator? |
| cord-017866-h5ttoo0z | Secondly, how are granule cargo proteins sorted to the same destination as other proteins that are essential for DCG function, such as membrane fusion machinery? |
| cord-003761-ikni2acz | A viral strategy to survive? |
| cord-003761-ikni2acz | The convergence of multiple signalling pathways on ROS production? |
| cord-272467-8heg5iql | How are these proteins confined to their appropriate destinations, rather than migrating onward to the plasma membrane? |
| cord-272467-8heg5iql | What features of each protein might be involved in determining its intracellular destination, and what are the mechanisms involved in each case? |
| cord-104279-choywmwd | The rate of bulk flow from the Golgi to the plasma membrane Protein degradation in the endoplasmic reticulum Membrane protein sorting: biosynthesis, transport, and processing of yeast vacuolar alkaline phosphatase A new class of lysosomal/ vacuolar protein sorting signals Protein glycosylation in yeast Rapid and efficient sitespecific mutagenesis without phenotypic selection Structure of a yeast pheromone gene( MFa): a putative a- factor precursor contains four tandem copies of mature c~-factor Mutations in the cytoplasmic domain of the 275 kd mannose 6-phosphate receptor differentially alter lysosomal enzyme sorting and endoeytosis Golgi retention signals: do membranes hold the key? |
| cord-104223-ht3ry9i0 | How are these intermediates segregated before formation of a dense core? |
| cord-007353-qg2pb884 | Inward- rectifying potassium channels in retinal glial( Muller) cells lntracellular aspects of the process of protein transport Glial cell diversification in the rat optic nerve A glial progenitor cell that develops in vitro into an astrocyte depending on culture medium Perturbation of the morphology of the trans Golgi network following Brefeldin A treatment: redistribution of a TGN- specific integral membrane protein, TGN38 Reactive astrocyte and axonal overgrowth in the injured CNS: is gliosis really an impediment to regeneration? |
| cord-007353-qg2pb884 | The in vivo and in vitro synthesis of sulphatides during development Preparation of separate astroglial and oligodendroglial cell cultures from rat cerebral tissue Pharmacologically- distinct subsets of astroglia can be identified by their calcium response to neuroligands ls reactive gliosis a property of a distinct subpopulation of astrocytes? |
| cord-296416-q0rsfzgw | In vitro veritas? |
| cord-016971-7esuj4ye | Does COPI go both ways? |
| cord-299281-5z1xminb | Glycophorin A dimerization is driven by specific interactions between transmembrane a- helices Polarized apical distribution of glycosyl- phosphatidylinositolanchored proteins in a renal epithelial cell line Golgi retention signals: do membranes hold the key? |
| cord-255981-3zvwu5bd | cAMP- PKA signaling? |
| cord-022499-7d58f1k3 | The structure of the potassium channel: Molecular basis of K+ conduction and selectivity Molecular sorting of lipids by bacteriorhodopsin in dilauroylphophatidylcholine/ distearoylphosphatidylcholine lipid bilayers Is the protein/ lipid hydrophobic matching principle relevant to membrane organization and functions? |
| cord-102964-zh737cjk | The shear stress- induced transcription factor KLF2 affects dynamics and angiopoietin-2 content of Weibel- Palade bodies Cell adhesion mechanisms in platelets Thrombosis in diabetes: a shear flow effect? |
| cord-317070-awip52k7 | The Golgi complex: in vitro veritas? |
| cord-319626-f1b3ygg0 | Is cytochrome P-450 transported from the endoplasmic reticulum to the Golgi apparatus in rat hepatocytes? |
| cord-018572-e2qq4ngq | What is the unifying principle in the broad range of functions defined for each one? |
| cord-018572-e2qq4ngq | Why so few? |
| cord-355580-4pv1zu1g | A signal sequence receptor in the endoplasmic reticulum raembrane Is cytochrome P-450 transported from the endoplasmic reticulum to the Golgi apparatus in rat hepatocytes? |
| cord-022354-aqtceqqo | Thus even in this well- defined situation, where an amino acid sequence is known to play a functional role in the sorting process, it can be impossible to predict with confidence its location in the protein; how then might we expect to identify additional sorting sequences that may or may not exist within the structural domain of a transported protein? |
| cord-022354-aqtceqqo | What then is the function of the cytoplasmic domain of the env glycoprotein? |
| cord-264468-3oxzzxnd | How then does translocated SseG account for bacterial association with the Golgi? |
| cord-104239-xxlcdbqi | The Gotgi complex: in vitro veritas? |
| cord-104231-fi8pskod | : the cytoplasmic domain contains two tyrosinedependent targeting determinants The Golgi complex: in vitro veritas? |
| cord-104231-fi8pskod | Golgi retention signals: do membranes hold the key? |
| cord-354726-b9xvycyk | Disulfide bonds in folding and transport of mouse hepatitis coronavirus glycoproteins Formation and intracellular transport of a heterodimeric viral spike protein complex Protein localization and virus assembly at intracellular membranes Coronavirus E1 glycoprotein expressed from cloned cDNA localizes in the Golgi region Viral protein synthesis in mouse hepatitis virus strain A59-infected cells: effects of tunicamycin Signal recognition particledependent insertion of coronavirus El, an intracellular membrane glycoprotein The budding of enveloped viruses: a paradigm for membrane sorting? |
| cord-298251-u36lb44w | ELMOD2 is an Arl2 GTPase- activating protein that also acts on Arfs Trafficking to the ciliary membrane: how to get across the periciliary diffusion barrier? |
| cord-313694-p2sgaypq | Decreased transfer of oligosaccharide from oligosaccharideqipid to protein acceptors in regenerating rat liver Stimulation of lipid- linked oligosaccharide assembly duing oviduct differentiation Cell- type- related segregation of surface galactosyl- containing components at an early developmental stage in hemopoietic bone marrow cells in the rabbit Changes in asparagine- linked sugar chains of human promyelocytic leukemic cells( HL-60) during monocytoid differentiation and myeloid differentiation Are glycoproteins and glycosaminoglycans components of the eukaryotic genome? |
| cord-313694-p2sgaypq | The accesibility to trypsin of the susceptible bonds in ovine submaxillary land mucoproteins Influenza C virus uses 9- 0-Acetyl- N- Acetylneuraminic Acid as a high affinity receptor determinant for attachment to cells Carbohydrate- binding sites of the mannose- specific fimbrial lectins of enterobacteria The mouse egg's receptor for sperm; What is it and how does it work? |
| cord-008590-xivnsldf | ( 1) the ionic content of the GC is unlike that the the RER and as a consequence a conformational change is induced in such membrane proteins which reduces their mobility- the possibility that the Golgi content may have unique ionic properties has recently been discussed( 136), or( 2) the protein encounters, within the membrane of Golgi cisternae, certain stable residents( proteins?) |
| cord-008590-xivnsldf | For example, is the compartment responsible for proteoglycan sulfation the same as that responsible for galactose addition to asparagine- linked oligosaccharides? |
| cord-008590-xivnsldf | How does the cell determine whether or not to add the blocked phosphate to a given oligosaccharide? |
| cord-008590-xivnsldf | What is the impact of housing these processing events on the GC, and what are some of the dividends for the cell? |
| cord-008590-xivnsldf | Why do these proteins, synthesized in the RER, exit only as far as this portion of the GC and migrate, if at all, only much more slowly to the cell surface? |
| cord-287477-aios0h8s | How can CoV-2 divert them to its advantage? |
| cord-326015-ky4y2xjt | Do other Golgi resident proteins display similar signals? |
| cord-265887-g5zhoyo9 | Alternatively, does the lipid- composition specificity of the C- terminal determine the conformational uptake and the eventual functional topology? |
| cord-265887-g5zhoyo9 | Do these hydrophobic interactions prompt the downstream oligomerization events to the formation of the membrane- associated multimers? |
| cord-265887-g5zhoyo9 | Does the C- terminal induce the initial docking of the protein to the host membranes? |
| cord-269011-230p8rsf | How, in the face of this enormous flexibility in accommodating all these various numbers and combinations of viral components, do coronaviruses manage to maintain specificity? |
| cord-022313-2675sjlf | Can we find, or synthesize, more specific inhibitors that act only on one enzyme? |
| cord-022313-2675sjlf | Could this compartment be the ER? |
| cord-022313-2675sjlf | How can we find better inhibitors? |
| cord-022313-2675sjlf | The puzzle here is the same as that mentioned earlier; i.e., Why is the formation of dolichyl- P- mannose inhibited, but not that of dolichyl- P- glucose? |
| cord-005034-wyipzwo4 | A number of glycosyltransferases have restricted distributions within the Golgi apparatus, notably/~1,4 galactosyltransferase(/? 1,4GalT) |
| cord-005034-wyipzwo4 | How could the three domains of a glycosyltransferase play a role in aggregation? |
| cord-005034-wyipzwo4 | What are the possible mechanisms for the compartmentspecific localization of the membrane- bound glycosyltransferases? |
| cord-005034-wyipzwo4 | What could be the basis of an active Golgi retention mechanism? |
| cord-005034-wyipzwo4 | What do we know about the sorting signals and mechanisms for the localization of non- Golgi proteins within the secretory and endocytic pathways? |
| cord-306067-ldn17pj8 | ;( c) does the L- chain play a role in the formation of the 30-kDa fhx/ P25? |
| cord-306067-ldn17pj8 | In the present study, we aimed at answering the following three specific questions:( a) where is the site of assembly of the elementary unit in PSG cells?;( b) what is the difference between 30-kDa and 27-kDa |
| cord-306067-ldn17pj8 | fhx/ P25? |
| cord-257754-pqxkyg8z | Biogenesis from scratch? |
| cord-257754-pqxkyg8z | Cvt17/ Aut5p aVect its function? |
| cord-257754-pqxkyg8z | Evidence for fusion of autophagosomes with both early and late endosomes Developmental features of autophagy in aging secretory cells of Tamarix aphylla salt glands Protein degradation in mitochondria: Implications for oxidative stress, aging and disease: A novel etiological classification of mitochondrial proteolytic disorders PpATG9 encodes a novel membrane protein that traYcs to vacuolar membranes which sequester peroxisomes during pexophagy in Pichia pastoris Identification of Icm protein complexes that play distinct roles in the biogenesis of an organelle permissive for Legionella pneumophila intracellular growth Fulvio Reggiori Autophagy and aging: The importance of maintaining Does autophagy contribute to cell death? |
| cord-257754-pqxkyg8z | These factors have no counterparts in S. cerevisiae or the homologs do not have a role in pexophagy.? |
| cord-322516-wekvet6f | A suggests an ER recycling pathway Golgi retention signals: do membranes hold the key? |
| cord-322516-wekvet6f | CA and FB1 do not? |
| cord-322516-wekvet6f | How does this fit with our model that ceramide mediates PDMP effects? |
| cord-322516-wekvet6f | in vitro veritas? |
| cord-022235-6ircruag | Do polarized cells sort and direct proteins directly to their target mem branes, or are they all first randomly targeted to both domains, or specifi cally to one or other domain, and then transcytosed? |
| cord-022235-6ircruag | How are proteins specifically retained in individual Golgi cisternae? |
| cord-022235-6ircruag | How then do secretory proteins move between these compart ments, and is the secretory pathway a continuous gradient of secretory organelles or are they functionally and structurally independent? |
| cord-022235-6ircruag | This raises two of the fundamental questions which will be addressed in this chapter, namely, what determines whether a protein will be taken out of circulation at a particular step in the pathway, and how tight is the separation between secretory organelles? |
| cord-022235-6ircruag | What happens to incorrectly folded proteins in the ER? |
| cord-268527-wbfnhedy | Rats in groups of six injected intravitreally with[ 35S]methionine only or[? 3]methionine and either catanospermine or swainsonine were dark adapted for 1 hr at which time retinas were collected for subcellular fractionation. |
| cord-268527-wbfnhedy | Six rats were injected intravitreally with[?! |
| cord-329515-ra20actc | A reveals an ER cycling pathway Immunocytochemical analysis of the transfer of vesicular stomatitis virus G glycoprotein from the intermediate compartment to the Golgi complex Golgi retention signals: do membranes hold the key? |
| cord-329515-ra20actc | What is the role of the cytoplasmic tail in conferring proper intracellular retention of p63? |
| cord-351964-hduv0ur4 | We can then ask at what level do the two pathways diverge? |
| cord-351964-hduv0ur4 | When both virions and condensing secretory proteins share the same dilation, they are well separated( lower leJ? and inset). |
| cord-351964-hduv0ur4 | proteins and are the two markers segregated into different populations of transport vesicles at the exit from this compartment? |
| cord-253466-7gpije5d | , 2004) induces vesicles and dispersal of the Golgi apparatus, which begs the questions, does this mutant use a different process for forming the replication complex, or do the mutations in 3A allow the proteins to compete with BFA for GBF1 recruitment? |
| cord-253466-7gpije5d | African swine fever virus is wrapped by the endoplasmic reticulum Cellular COPII proteins are involved in production of the vesicles that form the poliovirus replication complex Vaccinia virus membrane proteins p8 and p16 are cotranslationally inserted into the rough endoplasmic reticulum and retained in the intermediate compartment Daxx: Death or survival protein? |
| cord-253466-7gpije5d | Biogenesis from scratch? |
| cord-253466-7gpije5d | Hijacking components of the secretory pathway for replication of poliovirus RNA Does common architecture reveal a viral lineage spanning all three domains of life? |
| cord-253466-7gpije5d | Viral interactions with the cytoskeleton of mammalian cells Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex Assembly of vaccinia virus revisited: De novo membrane synthesis or acquisition from the host? |
| cord-264996-og3sg0qw | But how does a specific protein''know''how to reach a specific cellular destination when hundreds of newly synthesized, diVerent molecules require 2 specific transport and targeting? |
| cord-264996-og3sg0qw | The Next Generation of Medical Treatment? |
| cord-264996-og3sg0qw | The secrets of secretory lysosomes The biogenesis of lysosomes: Is it a kiss and run, continuous fusion and fission process? |
| cord-264996-og3sg0qw | This raises a key question: how do protein and lipid cargo move through the Golgi apparatus while resident enzymes retain their localization? |
| cord-264996-og3sg0qw | Where is it and what does it do? |
| cord-292688-w4zvfkyl | How does this signal- less type of cargo enter the CCVs allowing it to be removed? |
| cord-292688-w4zvfkyl | This raises a very intriguing set of questions: are there multiple classes of CCVs forming from the ISG all with a di¡erent cargo?, would these CCVs all have a di¡erent destination? |
| cord-292688-w4zvfkyl | This raises a very intriguing set of questions: are there multiple classes of CCVs forming from the ISG all with a di¡erent cargo?, would these CCVs all have a di¡erent destination? |
| cord-292688-w4zvfkyl | or is there a single species of CCVs forming with a mixed cargo? |
| cord-292688-w4zvfkyl | the membrane tra¤c police? |
| cord-292688-w4zvfkyl | would this CCV deliver its cargo to one destination, for example, the endosome, from where further sorting would occur? |
| cord-020788-a33vcapl | Are different signals recognized by the different epithelial cells or is the same signal interpreted differently? |
| cord-020788-a33vcapl | But if the VSVG ectodomain is randomly secreted and the VSVG tail domain fused to HA is apical, which domain of VSVG encodes basolateral sorting information? |
| cord-020788-a33vcapl | For example, is this cell derived from a tissue specialized for apical secretion or apical endocytosis? |
| cord-020788-a33vcapl | For the epithelial cell biologist, the obvious question is,"What brings about the pathway- specific localizations of rab proteins in polarized epithelial cells?" |
| cord-020788-a33vcapl | Is the sorting machinery itself different between polarized cells, or is the sorting machinery basically conserved between different cell- types while its regulation, adaptation, or wiring to the targeting machinery is different? |
| cord-020788-a33vcapl | Is the tight junction a barrier to diffusion in the plasma membrane? |
| cord-020788-a33vcapl | What does the LDLR gain by expressing two basolateral localization signals? |
| cord-020788-a33vcapl | Why do these proteins need multiple signals? |
| cord-323331-80d01l6f | A cause or a consequence? |
| cord-323331-80d01l6f | ARA160 is a BC- box- containing protein that mediates the degradation of Stat3 Onco- Golgi: is fragmentation a gate to cancer progression? |
| cord-323331-80d01l6f | Caspase- resistant Golgin-160 disrupts apoptosis induced by secretory pathway stress and ligation of death receptors Golgi disassembly in apoptosis: cause or effect? |
| cord-323331-80d01l6f | For example, is there an unfolded protein response( UPR)-like mechanism at the Golgi to cope with different stresses? |
| cord-323331-80d01l6f | How do the signaling pathways on the Golgi sense and transduce stress signals? |
| cord-323331-80d01l6f | Is there a common stress sensor on the Golgi? |
| cord-309384-vlk8cebh | Crystal structure of β- hexosaminidase B in complex with pyrimethamine, a potential pharmacological chaperone Induced secretion of β- hexosaminidase by human brain endothelial cells: a novel approach in Sandhoff disease? |
| cord-309384-vlk8cebh | Do mitochondria act as"cargo boats"in the journey of GD3 to the nucleus during apoptosis? |
| cord-309384-vlk8cebh | Galectin-1 is a major receptor for ganglioside GM1, a product of the growth- controlling activity of a cell surface ganglioside sialidase, on human neuroblastoma cells in culture Carbohydrate- to- carbohydrate interaction, through glycosynapse, as a basis of cell recognition and membrane organization Carbohydrate- Carbohydrate interaction in basic cell biology Carbohydrate- carbohydrate interactions in cell recognition Specific interaction between gangliotriaosylceramide( Gg3) and sialosyllactosylceramide( G(M3) as a basis for specific cellular recognition between lymphoma and melanoma cells Brain gangliosides in axon- myelin stability and axon regeneration Gangliosides and the multiscale modulation of membrane structure Receptor modifications in glycobiology Neural functions of glycolipids Lipid rafts: keys to neurodegeneration Regulation of human EGF receptor by lipids Gangliosides as components of lipid membrane domains Membrane organization and lipid rafts Revitalizing membrane rafts: new tools and insights Lipid rafts as a membraneorganizing principle Lipids and cholesterol as regulators of traffic in the endomembrane system Principles of microdomain formation in biological membranes- are there lipid liquid ordered domains in living cellular membranes? |
| cord-309384-vlk8cebh | MDR1 Pglycoprotein is a lipid translocase of broad specificity, while MDR3 P- glycoprotein specifically translocates phosphatidylcholine ABC lipid transporters: extruders, flippases, or flopless activators? |
| cord-309384-vlk8cebh | Pathogenic cascades in lysosomal diseasewhy so complex? |
| cord-309384-vlk8cebh | origin and function Nomenclature of glycolipids Neuronal dysfunction with aging and its amelioration Are globoseries glycosphingolipids SSEA-3 and-4 markers for stem cells derived from human umbilical cord blood? |
| cord-004521-25t4s7fr | ( synthesized in ERC?) |
| cord-004521-25t4s7fr | COP- free subways? |
| cord-004521-25t4s7fr | Chicken erythroid AE1 anion exchangers associate with the cytoskeleton during recycling to the Golgi Non- coordinate regulation of ENaC: paradigm lost? |
| cord-004521-25t4s7fr | For example, do they involve the new types of coats( membrane- shaping proteins) that recently have been suggested to operate in organelle formation and membrane traffic[ 83, 181]? |
| cord-004521-25t4s7fr | How to circumvent the central station? |
| cord-004521-25t4s7fr | If the TGN is not the principal recipient of ER- derived secretory cargo and the major site of its sorting in the Golgi apparatus, how is this system then organized? |
| cord-004521-25t4s7fr | Immunocytochemical analysis of Uukuniemi virus budding compartments: role of the intermediate compartment and the Golgi stack in virus maturation Structural maturation of the transmissible gastroenteritis coronavirus Assembly of vaccinia virus revisited: de novo membrane synthesis or acquisition from the host? |
| cord-004521-25t4s7fr | Or, what are the fusion factors( e.g. SNAREs) that function in the required intercompartmental transport events? |
| cord-004521-25t4s7fr | Retrograde transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol Surfing on a retrograde wave: how does Shiga toxin reach the endoplasmic reticulum? |
| cord-004521-25t4s7fr | The Golgi apparatus: 100 years of progress and controversy What can yeast tell us about N- linked glycosylation in the Golgi apparatus? |
| cord-004521-25t4s7fr | The Golgi apparatus: balancing new with old The Golgi complex: in vitro veritas? |
| cord-004521-25t4s7fr | The debate about transport in the Golgi-two sides of the same coin? |
| cord-004521-25t4s7fr | how many Ypt/ Rab- GTPases make a eukaryotic cell? |
| cord-271501-yjobthaj | Are there diseases related to the above Golgi membrane transporters? |
| cord-271501-yjobthaj | Can intrinsic activities of these different transporters be modulated by different effectors including cytosolic and lumenal nucleotides that are known to be competitive inhibitors of nucleotide sugar transport( Capasso and Hirschberg, 1984)? |
| cord-271501-yjobthaj | Do many of the Golgi membrane transporters have common structural features? |
| cord-271501-yjobthaj | Do transporters recycle between the Golgi and the ER? |
| cord-271501-yjobthaj | Is the expression of the different transporter proteins subject to transcriptional or translational regulation during different physiological conditions and development? |
| cord-271501-yjobthaj | Is this a general observation? |
| cord-271501-yjobthaj | Is this of relevance? |
| cord-271501-yjobthaj | To what extent may this be another regulatory mechanism of nucleotide sugar transport in mammals which use uridine and guanosine nucleotide sugars? |
| cord-271501-yjobthaj | To what extent will transporters for the same solute, which are localized in different organelles, differ in structure? |
| cord-271501-yjobthaj | What structural features determine that these transporters become localized in the Golgi apparatus and/or the endoplasmic reticulum and not another organelle? |
| cord-271501-yjobthaj | Where next? |
| cord-271501-yjobthaj | Will there be Golgi apparatuses in which there is major overlapping of these different proteins? |
| cord-271501-yjobthaj | Will there be polarization in the Golgi apparatus of these transporters in the same general manner as glycosyltransferases in some cells? |
| cord-271501-yjobthaj | Within the Golgi membrane, do the transporters and the transferases exist as structural or functional complexes? |
| cord-287815-alv30uk5 | Anyway? |
| cord-287815-alv30uk5 | Are There? |
| cord-287815-alv30uk5 | Are compartment boundaries defined by specific protein frameworks? |
| cord-287815-alv30uk5 | Does Transport through the Golgi Require Vesicular Carriers? |
| cord-287815-alv30uk5 | Does transport between Golgi compartments require vesicular carriers? |
| cord-287815-alv30uk5 | How Good Is the Evidence for the Current View of the Golgi? |
| cord-287815-alv30uk5 | How do microtubules interact with the Golgi elements? |
| cord-287815-alv30uk5 | How does lipid composition and organization affect transport? |
| cord-287815-alv30uk5 | How does the machinery responsible for forward traffic relate to the machinery controlling homotypic fusion? |
| cord-287815-alv30uk5 | How is specificity of forward and backward traffic regulated? |
| cord-287815-alv30uk5 | How many Golgi compartments are there? |
| cord-287815-alv30uk5 | If so, how do they function and how are they regulated? |
| cord-287815-alv30uk5 | If the medial Golgi serves only to mediate glycosylation reactions, why the characteristic cisternal morphology? |
| cord-287815-alv30uk5 | If vesicles are not involved, is transfer from donor to acceptor Golgi mediated by direct fusion, perhaps via tubular extensions? |
| cord-287815-alv30uk5 | In vitro veritas? |
| cord-287815-alv30uk5 | Is Transport through the Golgi Selective or Nonselective? |
| cord-287815-alv30uk5 | Is transport in vitro ever completely dependent on vesicle formation, even in the absence of BFA? |
| cord-287815-alv30uk5 | The fact that"transport"( i.e., G protein glycosylation) can occur in the absence of vesicle formation raises a number of important questions: What transport step(s) is actually being measured in vitro? |
| cord-287815-alv30uk5 | Vesicular Transport or Golgi Fusion? |
| cord-287815-alv30uk5 | What function does the stack structure have? |
| cord-287815-alv30uk5 | What is the relationship of the events reconstituted in vitro to those found in intact cells? |
| cord-287815-alv30uk5 | What is the role of tubules? |
| cord-287815-alv30uk5 | While transport vesicles may represent the most likely mechanism to accomplish transfer between compartments and/or individual cisternae, how strong is the evidence that they actually perform this function? |