bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
acute respiratory	388
coronavirus disease	374
en el	359
respiratory syndrome	337
clinical trials	309
pacientes con	300
severe acute	293
clinical trial	258
cq hcq	249
en pacientes	240
novel coronavirus	235
syndrome coronavirus	230
se recomienda	222
qt interval	221
los pacientes	212
systematic review	209
lupus erythematosus	203
qtc prolongation	202
severe covid	196
hospitalized patients	192
author funder	191
granted medrxiv	191
con covid	187
rheumatoid arthritis	186
copyright holder	184
systemic lupus	184
antiviral activity	166
patients treated	165
randomized clinical	160
side effects	158
version posted	157
viral load	153
made available	146
international license	144
qt prolongation	140
en los	137
adverse effects	136
observational study	134
intensive care	129
controlled trial	128
critically ill	122
el uso	121
control group	120
adverse events	118
lopinavir ritonavir	115
del paciente	113
medrxiv preprint	109
doc id	108
cord uid	108
peer review	106
hcq treatment	102
ill patients	102
observational studies	101
mg kg	100
randomized controlled	100
para el	97
cohort study	96
el paciente	95
clinical studies	95
viral replication	95
por covid	94
twice daily	93
mechanical ventilation	92
con el	92
respiratory distress	92
care unit	91
risk factors	89
interval prolongation	88
hcq use	88
type i	86
mg twice	86
distress syndrome	81
sample size	81
patients receiving	77
increased risk	76
con sospecha	76
hcq group	75
united states	74
immune response	72
case series	71
paciente con	71
antiviral effects	71
sin embargo	71
hcq alone	71
rheumatic diseases	70
antimalarial drugs	70
qtc interval	69
convalescent plasma	68
viral infections	67
chloroquine phosphate	67
patients hospitalized	66
vitro antiviral	66
significant difference	66
con un	66
host cell	65
hcq may	64
rights reserved	63
clinical improvement	63
cytokine storm	63
virus infection	62
viral entry	62
en un	62
autoimmune diseases	62
hcq azm	61
sars coronavirus	61
middle east	60
received hcq	60
heart failure	59
east respiratory	59
viral clearance	58
viral shedding	58
con una	58
spike protein	58
systematic reviews	58
standard care	58
label non	57
treating covid	57
health organization	57
world health	57
per day	57
new york	57
less toxic	56
viral rna	56
clinical efficacy	56
higher risk	56
disease severity	55
optimized dosing	55
el manejo	55
inflammatory cytokines	54
two groups	54
mg day	54
converting enzyme	54
se debe	54
clinical characteristics	54
por sars	53
dosing design	53
statistically significant	52
posted june	52
ventricular arrhythmia	52
without azithromycin	52
supplementary table	52
respiratory tract	52
el riesgo	52
pacientes en	52
coronavirus infection	52
un estudio	51
binding energy	51
mg daily	51
se ha	51
receiving hcq	51
mortality rate	51
drug administration	50
por el	50
moderate covid	50
hospital mortality	50
respiratory failure	49
infected patients	49
inhibiting sars	48
among patients	48
antiviral drugs	47
combination therapy	47
hospitalized covid	47
ebola virus	47
patients infected	47
hcq therapy	47
immune system	46
small sample	46
severe disease	46
el tratamiento	46
se puede	46
ec values	45
health care	45
cuidados intensivos	45
randomized trial	45
infectious diseases	44
retrospective cohort	44
en las	44
cell entry	44
el grupo	43
cardiovascular disease	43
clinical benefit	43
controlled trials	43
experimental studies	42
healthcare workers	41
effectively inhibit	41
viral infection	41
cardiac complications	41
virus replication	41
hcq az	41
lung injury	41
associated pneumonia	41
ventricular arrhythmias	40
safety profile	40
emergency use	40
emerged novel	40
loading dose	40
performed using	40
diabetes mellitus	40
recently emerged	40
propensity score	40
randomised controlled	40
clinical outcomes	39
chloroquine effectively	39
significant differences	39
public health	39
plasma convaleciente	39
toxic derivative	39
ng ml	39
por lo	39
retrospective study	39
high dose	38
epithelial cells	38
hydroxychloroquine sulfate	38
logistic regression	38
disease progression	38
apparent efficacy	38
necrosis factor	38
en cuenta	38
en una	38
vitro studies	38
total aes	37
shown apparent	37
low dose	37
present study	37
confirmed covid	37
host cells	37
human coronavirus	36
clinical course	36
included studies	36
exposure prophylaxis	36
cardiac arrest	36
heart disease	36
serious adverse	36
posted november	36
may also	35
treatment group	35
controlled clinical	35
molecular docking	34
high risk	34
animal models	34
label use	34
tumor necrosis	34
several studies	34
patients received	34
clinical data	34
antiviral effect	34
pilot study	33
antimalarial drug	33
treat covid	33
first day	33
human immunodeficiency	33
coronavirus pneumonia	33
con los	33
spike glycoprotein	33
posted may	33
body weight	33
i ifn	33
ventricular tachycardia	33
significant effect	32
hcq plus	32
mg per	32
retinal toxicity	32
significantly higher	32
immunodeficiency virus	32
hydroxychloroquine use	32
todos los	32
hcq monotherapy	32
case report	32
another study	32
hcq mono	32
disease course	31
treatment options	31
drug repurposing	31
use authorization	31
primary outcome	31
one patient	31
corrected qt	31
connective tissue	31
antiviral agents	31
en su	30
myocardial infarction	30
en uci	30
severe cases	30
cardiac toxicity	30
within days	30
immune responses	30
clinical practice	30
chloroquine hydroxychloroquine	30
se han	30
day follow	30
early treatment	30
long qt	30
sle patients	30
potent inhibitor	30
su uso	29
antiphospholipid syndrome	29
protease inhibitors	29
open label	29
pao fio	29
study design	29
clinical features	29
trial hydroxychloroquine	29
odds ratio	29
included patients	29
day mortality	29
cov infection	29
influenza virus	29
two drugs	29
los estudios	29
daily dose	29
inflammatory response	28
debe ser	28
con sdra	28
chloroquine diphosphate	28
taking hcq	28
rna viruses	28
among hospitalized	28
adjunctive therapy	28
como el	28
dosing regimen	28
compassionate use	28
shedding duration	28
mg bid	28
control arm	28
study conducted	28
clinical evidence	28
puede ser	27
induced hyperpigmentation	27
coronavirus infections	27
study using	27
icu admission	27
updated meta	27
prolonging drugs	27
dosing regimens	27
like receptor	27
healthy volunteers	27
critical care	27
pk pd	27
cardiac side	27
hcq azi	27
nucleic acid	27
new insights	27
recent study	27
del virus	27
immune cells	27
rna polymerase	27
es un	27
using hcq	27
new coronavirus	27
patients admitted	27
retrospective analysis	26
lower mortality	26
vitro activity	26
hcq mg	26
adult patients	26
dose group	26
microbiological effect	26
ace receptor	26
antirheumatic drugs	26
dendritic cells	26
old drug	26
hospital stay	26
el cual	26
type diabetes	26
inclusion criteria	26
study showed	26
mouse model	26
posted july	26
creative commons	26
authors declare	26
blood levels	25
main protease	25
york state	25
molecular dynamics	25
antiviral clearance	25
therapeutic options	25
cuidado intensivo	25
chloroquine inhibits	25
control groups	25
el momento	25
rapid antiviral	25
widely used	25
symptom onset	25
prolonged qt	25
en este	25
three times	25
heart rhythm	25
el inicio	25
cl pro	25
cardiac aes	25
one study	25
congestive heart	24
cardiac arrhythmias	24
en contra	24
several clinical	24
infection treated	24
testing positive	24
virus entry	24
sobre el	24
kcal mol	24
viral carriage	24
endosomal ph	24
en caso	24
comparison group	24
results showed	24
pilot observational	24
baseline qtc	24
teniendo en	24
moderate coronavirus	24
studies included	24
statistical analysis	24
hydroxychloroquine treatment	24
original paper	24
also found	24
side effect	24
el tiempo	23
postexposure prophylaxis	23
renal impairment	23
cell culture	23
even though	23
informed consent	23
membrane fusion	23
cytokine production	23
qt prolonging	23
antigen presentation	23
ongoing clinical	23
prolongation associated	23
hcq also	23
si el	23
kg day	23
severely ill	23
el personal	23
oxygen therapy	23
acute lung	23
cytokine release	23
adverse reactions	23
confirmed cases	23
hcq azithromycin	23
review board	23
viral particles	23
available data	22
consentimiento informado	22
es una	22
hydroxychloroquine azithromycin	22
potential therapeutic	22
high doses	22
del estado	22
corona virus	22
prolonged qtc	22
narrative review	22
interim guidance	22
patients testing	22
significant reduction	22
cell activation	22
untested patients	22
positive effect	22
plasma concentrations	22
selection bias	22
atrial fibrillation	22
sars cov	22
institutional review	22
tratamiento con	22
cardiac injury	22
clinical management	22
drug therapy	22
virus disease	22
recent studies	21
also showed	21
qt intervals	21
dosing schemes	21
para los	21
upper respiratory	21
tissue diseases	21
heart rate	21
studies showed	21
prolonging medications	21
los casos	21
weak bases	21
public profile	21
mcg ml	21
reactive protein	21
factors associated	21
drug interactions	21
protective effect	21
coronary artery	21
para pacientes	21
i interferon	21
falla respiratoria	21
states veterans	20
veterans hospitalized	20
tissue distribution	20
cardiovascular events	20
preliminary results	20
hydroxychloroquine usage	20
qt syndrome	20
en china	20
lung tissue	20
mortality rates	20
rheumatic disorders	20
es el	20
oxidative stress	20
without concomitant	20
para evitar	20
chain reaction	20
statistical significance	20
concomitant azithromycin	20
higher doses	20
mainly mild	20
es importante	20
adults hospitalized	20
blood concentrations	20
estos pacientes	20
median time	20
chikungunya virus	20
proinflammatory cytokines	20
antiphospholipid antibodies	20
case reports	20
low doses	20
severe respiratory	20
mean age	20
lung inflammation	20
nasopharyngeal swab	20
adverse event	20
sudden cardiac	20
hospital admission	20
cardiac death	20
significantly lower	20
disease control	20
mild covid	20
release syndrome	20
virus type	19
protease inhibitor	19
azithromycin among	19
los cuales	19
infected cells	19
infectious peritonitis	19
higher mortality	19
del covid	19
treated patients	19
hcq arm	19
feline infectious	19
qtc ms	19
plus azithromycin	19
large number	19
breast cancer	19
cual se	19
entre los	19
type ii	19
alto flujo	19
mrna expression	19
included reviews	19
cell lines	19
recovery trial	19
patients without	19
cardiovascular system	19
cardiovascular risk	19
zika virus	19
hasta el	19
lo tanto	19
primary studies	19
mortality risk	19
spectrum antiviral	19
una serie	19
drug discovery	18
comparative study	18
con enfermedad	18
reporting items	18
study population	18
forma rutinaria	18
cuando se	18
tratados con	18
cell line	18
vitro inhibition	18
durante el	18
global pandemic	18
preliminary report	18
dose cq	18
recomienda en	18
significant arrhythmias	18
therapeutic effect	18
chest ct	18
hcq showed	18
therapeutic efficacy	18
polymerase chain	18
six patients	18
currently available	18
preferred reporting	18
rmd patients	18
median age	18
insulin sensitivity	18
baseline characteristics	18
artery disease	18
terminal glycosylation	18
las recomendaciones	18
acuerdo con	18
ischemic heart	18
cell membrane	18
study found	18
regression model	18
commonly used	18
current evidence	18
risk patients	18
beneficial effects	18
receptor binding	18
se sugiere	18
qt ratio	18
either cq	18
solidarity trial	18
neither drug	18
interferon beta	18
increased mortality	18
task force	18
risk factor	18
viral loads	18
cyclic gmp	18
los efectos	18
high vs	18
severe pneumonia	18
lower respiratory	17
en covid	17
also reported	17
cq treatment	17
without az	17
cell death	17
reported using	17
common coronavirus	17
infective agents	17
dosage regimens	17
vivo studies	17
una estrategia	17
clinically significant	17
control study	17
ecg monitoring	17
hcq administration	17
whether hcq	17
two studies	17
hcq concentrations	17
dependent manner	17
two patients	17
relative risk	17
supportive care	17
rheumatic disease	17
organ failure	17
times daily	17
sialic acid	17
active site	17
vitro data	17
lo cual	17
contar con	17
ill covid	17
clinical study	17
hydroxychloroquine inhibits	17
clinical symptoms	17
nervous system	17
vitro study	17
antiviral drug	17
membrane oxygenation	17
el estudio	17
nasopharyngeal swabs	17
extracorporeal membrane	17
induced qt	17
cumulative dose	17
effective treatment	17
primary care	17
complications attributed	17
side chain	17
class ii	17
urgent need	17
analysis revealed	17
accepted article	17
viral genome	16
available evidence	16
long half	16
cols en	16
pacientes hospitalizados	16
las condiciones	16
five days	16
protein binding	16
comparado con	16
antiviral therapy	16
inhibit viral	16
del tratamiento	16
gene expression	16
virological cure	16
pharmacologic treatments	16
manejo del	16
hospitalised patients	16
sudden death	16
antiviral activities	16
routine care	16
infectious disease	16
clinical use	16
hcq blood	16
hcq doses	16
han sido	16
effect model	16
antiviral treatment	16
hcq prophylaxis	16
avian influenza	16
drug use	16
los trabajadores	16
hcq cq	16
low risk	16
hcq might	16
chronic treatment	16
vs low	16
hydroxychloroquine retinopathy	16
time points	16
ventricular fibrillation	16
carga viral	16
allowed without	16
collected data	16
without permission	16
qtc intervals	16
en estado	16
study hydroxychloroquine	16
continuous variables	16
reuse allowed	16
patients taking	16
docking studies	16
registry analysis	16
insulin resistance	16
without diabetes	16
adverse effect	16
myocardial injury	16
desde el	16
plasmodium falciparum	16
times higher	16
subgroup analysis	16
least one	16
day followed	16
literature review	16
compromiso pulmonar	16
multinational registry	16
broad spectrum	16
una vez	16
innate immune	16
randomized trials	16
inflammatory drugs	15
i fipv	15
effective concentration	15
hcq combined	15
target cells	15
clinical experience	15
septic shock	15
plasmodium vivax	15
ii fipv	15
pbs group	15
cell surface	15
negative conversion	15
taken together	15
pueden ser	15
positive patients	15
national institutes	15
emitir una	15
mediated endocytosis	15
post hoc	15
peripheral blood	15
cardiac arrhythmia	15
para su	15
iron homeostasis	15
life cycle	15
care alone	15
longest daily	15
trial clinical	15
exclusion criteria	15
los niveles	15
pacientes covid	15
significant risk	15
hcq chloroquine	15
like receptors	15
inhibit sars	15
measured qtc	15
patients died	15
binding energies	15
dificultad respiratoria	15
amp synthase	15
respiratory infections	15
using cq	15
proteolytic processing	15
randomized control	15
el estado	15
choudhary sharma	15
single center	15
macrophage activation	15
si se	15
renal failure	15
data regarding	15
recomienda realizar	15
significant qtc	15
hydroxychloroquine alone	15
treatment groups	15
controlled studies	15
las cuales	15
cardiovascular death	15
modifying antirheumatic	15
daily measured	15
immunomodulatory effects	15
pulmonary disease	15
potential treatment	15
las personas	15
los servicios	15
virologic cure	15
scientific community	15
favor fundamento	15
iron metabolism	15
study also	15
structural proteins	15
lymphocyte count	15
los recursos	15
monoclonal antibody	14
supplementary material	14
asymptomatic patients	14
hazard ratio	14
sensitivity analysis	14
significant decrease	14
dose chloroquine	14
endosomal acidification	14
lead ecg	14
clinical status	14
fight covid	14
antiviral agent	14
faers aers	14
study period	14
term treatment	14
drug chloroquine	14
es necesario	14
assessed using	14
data collection	14
sustained ventricular	14
beneficial effect	14
del personal	14
qtc prolonging	14
treatment strategies	14
optimal dosing	14
unfavorable outcome	14
ha sido	14
pcr test	14
categorical variables	14
first case	14
amino acid	14
pandemia covid	14
confidence interval	14
viral diseases	14
presenting cells	14
effective treatments	14
clinical recovery	14
entre el	14
con pacientes	14
pediatric patients	14
asociado con	14
high levels	14
pooled analysis	14
ms ms	14
infection control	14
mg times	14
safety profiles	14
virus adsorption	14
sample sizes	14
hospitalised covid	14
care data	14
deben ser	14
el traslado	14
renal disease	14
como una	14
donde se	14
congenital malformations	14
intravenous immunoglobulin	14
cardiovascular complications	14
flow nasal	14
para evaluar	14
del uso	14
medical care	14
entry depends	14
potential risk	14
infected pneumonia	14
phase iii	14
coronavirus sars	14
respiratory support	14
invasive ventilation	14
controlled study	14
decreased mortality	14
significantly associated	14
en paciente	14
nasal cannula	14
electronic medical	14
el sars	14
data extraction	14
previous studies	14
patient population	14
ra patients	14
binding affinity	14
hcq dose	14
un mayor	13
negative effect	13
el consentimiento	13
estancia en	13
para sars	13
cq may	13
nadph oxidase	13
placebo group	13
patients showed	13
human monocytes	13
serine protease	13
respiratory disease	13
confidence intervals	13
cellular iron	13
hcq treated	13
using routine	13
patients given	13
sars patients	13
low ph	13
care units	13
term use	13
viral decline	13
viral activity	13
tested positive	13
genetic polymorphisms	13
los criterios	13
therapeutic effects	13
approved drug	13
cause mortality	13
fatality rate	13
el objetivo	13
among covid	13
secondary outcomes	13
noninvasive ventilation	13
lysosomotropic agents	13
chronic obstructive	13
medical records	13
dependent rna	13
ivermectin prophylaxis	13
approved drugs	13
disminuir el	13
nan doi	13
con hipoxemia	13
inhibitory effect	13
drug treatment	13
falla renal	13
inflammatory effects	13
observational comparative	13
first trimester	13
load reduction	13
ocular toxicity	13
coxiella burnetii	13
en cuanto	13
rpe cells	13
clinically proven	13
based pharmacokinetic	13
endothelial cells	13
receive hcq	13
long term	13
systemic inflammation	13
del sistema	13
con respecto	13
require oxygen	13
pk model	13
higher rate	13
basado en	13
nitric oxide	13
vero cells	13
autoimmune rheumatic	13
american college	13
lysosomal activity	13
alto riesgo	13
health emergency	13
reduced mortality	13
endothelial dysfunction	13
plasma therapy	13
cancer cells	13
con las	13
dendritic cell	13
small number	13
kidney disease	13
strong evidence	13
severe patients	13
therapeutic agents	13
veroe cells	13
mg dl	13
un protocolo	13
hospitalizados con	13
missing data	13
like protease	13
data suggest	13
clinical outcome	13
viral proteins	12
fold increase	12
erythematosus patients	12
psoriatic arthritis	12
trial conducted	12
random effects	12
standard deviation	12
cohort studies	12
commons licence	12
studies hydroxychloroquine	12
several limitations	12
clinical implications	12
adaptive immune	12
treatment effects	12
either alone	12
los primeros	12
significantly reduced	12
early phase	12
google scholar	12
ethics committee	12
current knowledge	12
given hcq	12
frecuencia respiratoria	12
significant increase	12
therapeutic use	12
care medicine	12
hcq groups	12
use hcq	12
concomitant use	12
left ventricular	12
hcq based	12
intervention arm	12
en salud	12
three patients	12
oral administration	12
health commission	12
mental health	12
tener en	12
rheumatic drugs	12
mild cases	12
las muestras	12
primary endpoint	12
cleavage site	12
available weapons	12
one day	12
central nervous	12
los resultados	12
grupo control	12
promising results	12
coronavirus replication	12
general population	12
patients may	12
potential role	12
cuenta con	12
pacientes recibieron	12
patient outcomes	12
receptor ace	12
dengue virus	12
widespread use	12
observational cohort	12
findings suggest	12
randomized study	12
iron deficiency	12
routinely collected	12
antiviral efficacy	12
plasma levels	12
well tolerated	12
el rendimiento	12
retinal pigment	12
arthritis patients	12
las medidas	12
patient characteristics	12
proven protease	12
renal aguda	12
may increase	12
early stage	12
uso del	12
el contexto	12
cardiac disease	12
rna synthesis	12
treatment option	12
quality evidence	12
obstructive pulmonary	12
multivariate analysis	12
drug effect	12
original data	12
may lead	12
vivax malaria	12
label nonrandomized	12
las primeras	12
methodological quality	12
puede emitir	12
physical activity	12
mayor riesgo	12
studies reported	12
hydroxychloroquine dosing	12
way anova	12
including patients	12
south korea	12
effective drug	12
innate immunity	12
mhc class	12
metabolic syndrome	12
antiviral properties	11
randomized studies	11
oral hcq	11
efectos adversos	11
guangdong province	11
recomienda el	11
related coronavirus	11
french study	11
sepsis campaign	11
este estudio	11
el nivel	11
urgently needed	11
positive pcr	11
baseline ecg	11
current pandemic	11
maintenance dose	11
determine whether	11
four days	11
ha demostrado	11
taking cq	11
cells infected	11
treating sars	11
induced myopathy	11
pacientes tratados	11
treatment guidelines	11
mild moderate	11
two different	11
statistical evidence	11
immune activation	11
also suggested	11
viral pneumonia	11
inflammatory arthritis	11
staphylococcus aureus	11
el fin	11
existe una	11
stable binding	11
using routinely	11
aumento en	11
forest plots	11
como los	11
malaria treatment	11
respiratorio agudo	11
prolonged viral	11
modifying anti	11
higher proportion	11
composite endpoint	11
protective equipment	11
inflammatory responses	11
deteriorated patients	11
enfermedad severa	11
plus az	11
action potential	11
signalling pathways	11
clinical research	11
antigen processing	11
chronic kidney	11
drug concentrations	11
chronic hydroxychloroquine	11
un paciente	11
untreated cells	11
mortality associated	11
competing risks	11
also used	11
adult inpatients	11
surviving sepsis	11
viral particle	11
placebo controlled	11
cuidados paliativos	11
arrhythmic manifestations	11
mononuclear cells	11
might also	11
drug discontinuation	11
ct findings	11
viral envelope	11
endosomal tlr	11
significantly longer	11
induced cardiomyopathy	11
cardiovascular mortality	11
saudi arabia	11
animal toxicity	11
covid infection	11
estudio retrospectivo	11
higher rates	11
matched cohort	11
inflammatory cytokine	11
day course	11
publication bias	11
organic anion	11
prospective cohort	11
data sets	11
ml min	11
los siguientes	11
icu patients	11
without hcq	11
severe side	11
inhibitory effects	11
por un	11
alveolar macrophages	11
care workers	11
risk covid	11
liver injury	11
angiotensin converting	11
oxygen saturation	11
conformational changes	11
although hcq	11
vitro hydroxychloroquine	11
commons attribution	11
patient treated	11
vitro efficacy	11
prolonging agents	11
three studies	11
del equipo	11
con tcz	11
trial efficacy	11
search terms	11
sialic acids	11
possible role	11
including sars	11
national health	11
los medicamentos	11
prospective study	11
con mayor	11
hcq compared	11
respiratory infection	11
antimalarial agents	11
concerns regarding	11
either hcq	11
hospital discharge	11
herpes simplex	11
disease exacerbation	11
mechanically ventilated	11
also shown	11
por coronavirus	11
inflammatory diseases	10
psychiatric disorders	10
una mayor	10
potential drug	10
medical conditions	10
raw data	10
higher incidence	10
infection chloroquine	10
effects model	10
el primer	10
less likely	10
low cost	10
hcq pk	10
therapeutic option	10
first study	10
diseases hydroxychloroquine	10
patients suspected	10
realizar el	10
laboratory tests	10
clinical setting	10
cell fusion	10
tomar decisiones	10
fever endocarditis	10
cardiac adverse	10
functional receptor	10
target trial	10
hydroxychloroquine therapy	10
disease activity	10
search strategy	10
renal clearance	10
regression analyses	10
en tiempos	10
viral spike	10
global health	10
social media	10
los respiradores	10
data analysis	10
anecdotal evidence	10
negative pcr	10
heart block	10
statistical analyses	10
mg three	10
posted april	10
oral dose	10
currently used	10
expression levels	10
recomienda utilizar	10
based treatment	10
hydroxychloroquine reduces	10
virus cell	10
ser una	10
mg hcq	10
oxygen requirement	10
se pueden	10
higher dose	10
systemic sclerosis	10
early endosomes	10
induced lqt	10
feline coronavirus	10
rhythm society	10
also observed	10
emerging evidence	10
salud mental	10
eventos adversos	10
nonrandomized clinical	10
limited data	10
reference group	10
published data	10
treatment initiation	10
chloroquine hcq	10
como un	10
chloroquine treatment	10
mild symptoms	10
proportional hazards	10
patients affected	10
significantly decreased	10
recomienda considerar	10
virological clearance	10
major congenital	10
puede considerar	10
known risk	10
las horas	10
plasmacytoid dendritic	10
confirmed sars	10
infect dis	10
experimental group	10
usual care	10
well known	10
cardiac risk	10
mortality among	10
discharge home	10
states food	10
study included	10
tumor growth	10
systematic search	10
also known	10
total dose	10
dis doi	10
lung involvement	10
use associated	10
airway epithelial	10
potentially lethal	10
sprotein rbd	10
drug development	10
single dose	10
hcq users	10
pulmonary ct	10
conduction disorders	10
new drug	10
simplex virus	10
drug ivermectin	10
compound library	10
binding domain	10
cardiotoxic effects	10
early stages	10
repurposed drugs	10
hipoxemia refractaria	10
hcq conjugate	10
proteolytic cleavage	10
tracto respiratorio	10
los epp	10
key role	10
higher probability	10
vaccine development	10
ivermectin inhibits	10
prone positioning	10
relacionadas con	10
drugs used	10
el virus	10
en algunos	10
dose hcq	10
study reported	10
important role	10
york city	10
multicenter randomized	10
healthcare settings	10
study group	10
concomitant qt	10
lung exposure	10
treatment regimen	10
negative rt	10
significantly different	10
pcr para	10
including hcq	10
quality assessment	10
ace expression	10
nucleic acids	10
en estos	10
clinical decision	10
drugs chloroquine	10
debe considerar	10
estancia hospitalaria	10
molecular mechanism	10
personal protective	10
one month	10
healthy individuals	10
respiratoria aguda	10
del plasma	10
md simulation	10
life threatening	10
hydroxychloroquine tablets	10
event reporting	10
en esta	10
medical community	10
branch block	10
used hcq	10
inflammatory rheumatic	10
elimination half	10
atrioventricular block	10
sensitivity analyses	10
data variants	10
high concentrations	10
open access	10
el punto	10
raised concerns	10
regression analysis	10
clinical presentation	10
lower risk	10
cox proportional	9
human airway	9
review hydroxychloroquine	9
autoimmune disease	9
study performed	9
like behavior	9
en wuhan	9
mass index	9
lung model	9
ill adults	9
seguridad del	9
medical research	9
widely available	9
long time	9
refractory ventricular	9
drug interaction	9
para determinar	9
early covid	9
copies ml	9
preventing infection	9
az combination	9
induced lung	9
reduced risk	9
greater risk	9
dentro del	9
therapeutic potential	9
erythematosus hydroxychloroquine	9
lysosome fusion	9
prophylactic drug	9
placebo control	9
body mass	9
compared hcq	9
ventilated patients	9
term care	9
wide range	9
bundle branch	9
previously published	9
el procedimiento	9
statistical computing	9
hospital death	9
evitar el	9
malignant ventricular	9
evaluar el	9
regression models	9
un grupo	9
national institute	9
chronic hepatitis	9
todas las	9
dosing scheme	9
green monkey	9
phase i	9
studies conducted	9
small molecule	9
el proceso	9
outcome measures	9
standard treatment	9
mg cq	9
different dosing	9
corticosteroid therapy	9
prolong qtc	9
health systems	9
pacientes sin	9
electrolyte abnormalities	9
acidic ph	9
severe adverse	9
pcr results	9
iron starvation	9
population pk	9
clinical effects	9
times day	9
health crisis	9
el retiro	9
existe evidencia	9
plasma protein	9
will need	9
drug safety	9
envelope protein	9
analyzed using	9
potential inhibitors	9
hcq exposed	9
first days	9
arm studies	9
mortalidad en	9
among healthcare	9
transporting polypeptide	9
short period	9
activated protein	9
possible mechanisms	9
respiratory illness	9
replication cycle	9
protein kinase	9
severe qtc	9
kidney injury	9
muscle cells	9
en medicina	9
human subject	9
ic del	9
limited evidence	9
pregnant women	9
genomic rna	9
drugs strongly	9
patients suffering	9
antibody responses	9
targeting endosomal	9
developing countries	9
acute kidney	9
large volume	9
older age	9
cardiac safety	9
iib clinical	9
el marco	9
corticosteroid treatment	9
three groups	9
may cause	9
hcq dosing	9
plasma membrane	9
tlr signaling	9
much higher	9
transcription factor	9
significantly inhibited	9
active metabolite	9
study protocol	9
moderate grade	9
animal studies	9
studies show	9
supplemental oxygen	9
moderate cases	9
kj mol	9
acidic organelles	9
large randomized	9
lysosomal ph	9
cardiac events	9
por encima	9
monkey kidney	9
del compromiso	9
contra el	9
personalized medicine	9
dos veces	9
dependent entry	9
del estudio	9
radiological progression	9
hydroxychloroquine chloroquine	9
high mortality	9
group compared	9
whole blood	9
also inhibit	9
adverse outcomes	9
entry stages	9
descriptive study	9
odds ratios	9
lung concentrations	9
binding sites	9
protein complex	9
risk ratio	9
analysis showed	9
animal model	9
recently published	9
immunomodulatory properties	9
con sars	9
study outcomes	9
current study	9
coronavirus spike	9
el plasma	9
springer nature	9
cells via	9
study used	9
receptor signaling	9
retrospective observational	9
todo el	9
control trials	9
phase iib	9
pulmonary embolism	9
hoc analysis	9
acute myocardial	9
pharmacokinetic studies	9
pk parameters	9
new england	9
clinical progression	9
del tracto	9
calculated using	9
hcq exposure	9
critical illness	9
del inicio	9
one hundred	9
se considera	9
pharmacological properties	9
del recurso	9
may help	9
disease caused	9
total number	9
therapeutic drugs	9
hydrogen bonding	9
overall effect	9
early outpatient	9
se deben	9
betulinic acid	9
drug combination	9
por los	9
results suggest	9
macrolide antibiotics	9
significantly increased	9
crucial role	9
expert consensus	9
activation syndrome	9
soporte ventilatorio	9
pooled risk	9
pacientes adultos	9
macaque model	9
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potential anti	9
reported data	9
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icu care	9
risk score	9
inflammatory properties	9
clinical effectiveness	9
th day	9
recovery time	9
subject research	9
sobre los	9
clinical manifestations	9
hcq appears	9
en todos	9
th cells	9
dna methylation	9
hcq dosage	9
outcomes included	8
suspected covid	8
data available	8
el plan	8
immunomodulatory effect	8
five patients	8
different cell	8
oral clefts	8
hcq combination	8
treated group	8
therapeutic agent	8
also associated	8
subgroup analyses	8
prm protein	8
relatively low	8
vitro experiments	8
concomitant pneumonia	8
published maps	8
novel severe	8
cuales se	8
hcq efficacy	8
en falla	8
human ace	8
standard therapy	8
negative patients	8
personal sanitario	8
including age	8
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potential antiviral	8
lung disease	8
computed tomography	8
hcq inhibits	8
invasive mechanical	8
inhibiting viral	8
also included	8
cancer patients	8
strategic national	8
jurisdictional claims	8
published studies	8
stem cells	8
blood hydroxychloroquine	8
nervioso central	8
coronavirus entry	8
uso en	8
lung cells	8
urgent guidance	8
severe coronavirus	8
por su	8
hospital setting	8
aquellos pacientes	8
closely related	8
ongoing trials	8
serum creatinine	8
blood pressure	8
used cq	8
authors concluded	8
two main	8
lupus anticoagulant	8
better understand	8
hcq include	8
los elementos	8
pulmonary inflammation	8
hubei province	8
march th	8
pneumonia outbreak	8
dry cough	8
post exposure	8
among others	8
torsadogenic potential	8
global rheumatology	8
trial chloroquine	8
effect size	8
hydroxychloroquine sulphate	8
treatment effect	8
los diferentes	8
therapeutic drug	8
human influenza	8
experimental study	8
may reduce	8
mpro enzyme	8
different countries	8
ace receptors	8
se le	8
term hydroxychloroquine	8
death rate	8
pooled incidence	8
un modelo	8
institutional affiliations	8
chloroquine chloroquine	8
day post	8
disease states	8
cardiac ae	8
pandemia por	8
adjusted odds	8
endoplasmic reticulum	8
original author	8
potential adverse	8
many countries	8
con falla	8
specific treatment	8
se presenta	8
newborn mice	8
enfermedad por	8
vitro chloroquine	8
alveolar epithelial	8
endosomal nadph	8
incubation period	8
laboratory confirmed	8
intracellular bacteria	8
human organic	8
reduce mortality	8
discontinuation due	8
complex system	8
reporting system	8
qtc msec	8
arrhythmic safety	8
qrs duration	8
anion transporting	8
en salas	8
lung damage	8
weak base	8
primeras horas	8
ec value	8
coronavirus pandemic	8
therapeutic strategies	8
log copies	8
med doi	8
convaleciente en	8
virologic efficacy	8
study designs	8
maximal effective	8
sistema nervioso	8
ordinal scale	8
cell viability	8
first report	8
gastrointestinal symptoms	8
national stockpile	8
cq base	8
acidic environment	8
rheumatic autoimmune	8
los cambios	8
hiv infection	8
still ongoing	8
potentially fatal	8
infection rate	8
despite lack	8
cq group	8
structural basis	8
antimalarial agent	8
adverse drug	8
scientific evidence	8
skeletal muscle	8
significant improvement	8
immunomodulatory drugs	8
el efecto	8
diseases treated	8
genotoxic effects	8
two large	8
hong kong	8
short courses	8
vena cava	8
comorbid conditions	8
disease modifying	8
two major	8
es posible	8
rhesus macaques	8
interquartile range	8
total cholesterol	8
trial design	8
target mpro	8
rheumatology alliance	8
increased qtc	8
novel covid	8
may affect	8
pacientes se	8
hcq per	8
hepatitis virus	8
mg loading	8
interaction diagrams	8
authors also	8
end point	8
qtc monitoring	8
nature remains	8
insulin secretion	8
crp level	8
hcq studies	8
moderate disease	8
falsos negativos	8
retrospective case	8
histocompatibility complex	8
en situaciones	8
also indicated	8
lupus patients	8
hospital settings	8
several countries	8
tubular secretion	8
different types	8
lung ph	8
patients also	8
important lessons	8
escala news	8
patients requiring	8
remains neutral	8
entre otros	8
plasma concentration	8
las unidades	8
significant association	8
tocilizumab therapy	8
molecular weight	8
con base	8
base en	8
furosemide treatment	8
monitoring protocol	8
en sdra	8
first time	8
para establecer	8
kawasaki disease	8
hydroxychloroquine prophylaxis	8
index date	8
trials will	8
vitro results	8
remained significant	8
hace protein	8
ventricular repolarization	8
soporte respiratorio	8
lysosomal function	8
los protocolos	8
major histocompatibility	8
human epithelial	8
controlled case	8
cq inhibits	8
induced toxic	8
diseases like	8
con alta	8
potential confounders	8
many drugs	8
sao fio	8
malarial drugs	8
potential conflicts	8
ammonium chloride	8
el equipo	8
next days	8
para lograr	8
healthy subjects	8
imaging findings	8
fda approved	8
van den	8
low incidence	8
se encontraban	8
se realiza	8
se encuentran	8
todo paciente	8
within hours	8
may improve	8
day one	8
bat origin	8
los participantes	8
future studies	8
cell receptor	8
las decisiones	8
least days	8
autophagic flux	8
symptom severity	8
conduction abnormalities	8
dosage regimen	8
vesicular stomatitis	8
chest pain	8
positive sars	8
china clinical	8
death due	8
del procedimiento	8
indian council	8
either drug	8
associated coronavirus	8
reduce viral	8
nonrandomized studies	8
hydroxyferroquine derivatives	8
blood cells	7
vina score	7
hcq trials	7
steady state	7
analysis date	7
data cleaning	7
patient died	7
participants took	7
mediated diseases	7
hydrogen bonds	7
combinational therapy	7
chinese clinical	7
therapeutic role	7
familial mediterranean	7
sinha balayla	7
limited sample	7
consensus statement	7
grade ventricular	7
continuous telemetry	7
treatment regimens	7
treat patients	7
aldosterone system	7
infection hydroxychloroquine	7
cutaneous lupus	7
un total	7
serum concentrations	7
conventional treatment	7
troponin i	7
phase trial	7
drug used	7
las manifestaciones	7
chinese center	7
tocilizumab may	7
treatment compared	7
irb approval	7
un hospital	7
hydrogen bond	7
stranded rna	7
infection among	7
complete heart	7
nuclear factor	7
para predecir	7
soporte vital	7
bajo flujo	7
two small	7
renal excretion	7
excluded patients	7
special reference	7
pcr testing	7
cell cultures	7
review date	7
different modes	7
disease virus	7
threatening covid	7
hcq mox	7
like disease	7
used early	7
discovery trial	7
johns hopkins	7
chloroquine analogs	7
fold higher	7
viral transmission	7
data set	7
inflammatory agent	7
double blind	7
los valores	7
bloqueo neuromuscular	7
drug concentration	7
data show	7
lower dose	7
una herramienta	7
prescribed hcq	7
evidence suggests	7
hydroxyl analogue	7
investigators found	7
assessing risk	7
puede tener	7
apl antibodies	7
see table	7
acute coronary	7
ventricular hypertrophy	7
i ku	7
como en	7
cause acute	7
note springer	7
approved compound	7
safety results	7
las metas	7
proven effective	7
recently reported	7
trial observational	7
respiratory specimens	7
debe realizarse	7
histoplasma capsulatum	7
resource allocation	7
significant change	7
immunomodulatory agents	7
data obtained	7
oral doses	7
respiratory viral	7
library identifies	7
en promedio	7
eular recommendations	7
large observational	7
lung ct	7
volumen corriente	7
using different	7
consecutive patients	7
modeling approach	7
tissue concentrations	7
locomotor activity	7
en cuidado	7
african green	7
common adverse	7
scientific statement	7
linear regression	7
un procedimiento	7
critical covid	7
large uncertainty	7
submitted work	7
tract infections	7
se cuenta	7
concurrent use	7
host defense	7
previously mentioned	7
old woman	7
index studies	7
intracellular pathogens	7
pero se	7
pigment epithelium	7
macrolide antibiotic	7
numerous studies	7
cumulative doses	7
american heart	7
human body	7
high cumulative	7
old female	7
hcq due	7
viral life	7
authors report	7
related diseases	7
basada en	7
study results	7
identificar pacientes	7
del esfuerzo	7
los hallazgos	7
done using	7
el seguimiento	7
hcq levels	7
block viral	7
durante su	7
fulminant myocarditis	7
hipoxemia severa	7
recurso humano	7
estudio observacional	7
safety data	7
control studies	7
may still	7
phase ii	7
blood samples	7
hcq prep	7
dose selection	7
viral nucleic	7
antirheumatic drug	7
para identificar	7
physicochemical properties	7
virus clearance	7
potential effect	7
current status	7
social distancing	7
el remdesivir	7
decision making	7
liver enzymes	7
enrolled patients	7
por esto	7
como las	7
dose hydroxychloroquine	7
para mejorar	7
en mayo	7
site residues	7
human subjects	7
hcq regimens	7
peritonitis virus	7
kawasaki syndrome	7
safety signals	7
cell transfer	7
preliminary safety	7
pooled prevalence	7
el compromiso	7
rhesus macaque	7
baseline use	7
identifies four	7
para definir	7
low molecular	7
cardiovascular aes	7
discharge rates	7
mouse hepatitis	7
relatively high	7
treated cells	7
las siguientes	7
pandemic influenza	7
significativa en	7
outbreak associated	7
similar findings	7
hcq concentration	7
relatively safe	7
study date	7
cq also	7
endocytic pathway	7
class i	7
viral effects	7
pregnancy outcomes	7
cardiac involvement	7
moderate risk	7
st century	7
potential conflict	7
authors found	7
older patients	7
epigenetic mechanisms	7
unchanged drug	7
premature ventricular	7
drugs inhibit	7
medication use	7
underlying cardiovascular	7
golgi vesicles	7
menor complejidad	7
organ damage	7
cardiovascular risks	7
epub ahead	7
robust evidence	7
available clinical	7
oc infection	7
preclinical studies	7
late endosomes	7
international committee	7
drug may	7
disease patients	7
hospitalized adults	7
overall rr	7
previously reported	7
also increase	7
severe lung	7
los biomarcadores	7
luego del	7
thrombotic events	7
see supplementary	7
effect profile	7
colchicine therapy	7
intracellular organelles	7
study showing	7
neurological manifestations	7
ion channel	7
ataque cerebrovascular	7
limited number	7
low toxicity	7
chronic use	7
mediterranean fever	7
una unidad	7
series study	7
troponina i	7
heart association	7
treat malaria	7
hospital admissions	7
plasma proteins	7
del sars	7
study cohort	7
conflicting results	7
realizaron un	7
host immune	7
asociados con	7
received mg	7
protein levels	7
dynamics simulation	7
medical record	7
probable bat	7
sectional study	7
causal inference	7
pcr positive	7
el hospital	7
negative results	7
en dos	7
gastrointestinal side	7
still lacking	7
inhibitor use	7
qtc relationship	7
line treatment	7
lesser extent	7
readily available	7
del riesgo	7
square test	7
excess risk	7
estudios han	7
azithromycin alone	7
treatment outcomes	7
risk assessment	7
thrombotic effects	7
iron retention	7
data sources	7
inmunoglobulina hiperinmune	7
may explain	7
group showed	7
cells chloroquine	7
lessons learned	7
first two	7
million people	7
outpatient setting	7
renal en	7
un tratamiento	7
ejection fraction	7
study aimed	7
nucleoside analog	7
drugs like	7
malaria drug	7
strong antiviral	7
improves survival	7
cancer cell	7
hcq versus	7
hydroxychloroquine concentration	7
methodological flaws	7
clinical guidelines	7
una enfermedad	7
un tiempo	7
tropheryma whipplei	7
las diferentes	7
reported cases	7
impaired clearance	7
tissue concentration	7
el soporte	7
case studies	7
guinea pig	7
phosphate dehydrogenase	7
inhibits proinflammatory	7
pacientes infectados	7
symptomatic disease	7
ph levels	7
level evidence	7
corona viruses	7
manuscript www	7
line represents	7
antiarrhythmic drugs	7
cell types	7
study clinical	7
full text	7
considerar en	7
preliminary data	7
showed significant	7
plasma hcq	7
withdrawals due	7
high rate	7
pcr tests	7
preprint servers	7
underlying diseases	7
prophylactic role	7
recent report	7
without azn	7
multicentre trial	7
induced qtc	7
high quality	7
xanthine oxidase	7
single oral	7
trial data	7
possible pharmacotherapies	7
monoclonal antibodies	7
entre otras	7
riesgo para	7
average treatment	7
drug reactions	7
las estrategias	7
cellular receptor	7
encouraging results	7
cellular uptake	7
glucose homeostasis	7
potential candidates	7
inflammatory markers	7
therapeutic targets	7
potential drugs	7
platelet aggregation	7
reduces fatality	7
el ingreso	7
tissue damage	7
ill patient	7
among hcws	7
sinus bradycardia	7
lys hotspot	7
vacuolar myopathy	7
body temperature	7
drugs may	7
generally considered	7
recommended doses	7
viral fusion	7
studies found	7
dose mg	7
mg orally	7
hcq seems	7
un nivel	7
inhibits viral	7
emergency approval	7
reduced lung	7
growth factor	6
igiv en	6
nucleotide analogs	6
congenital heart	6
healthcare personnel	6
realizado por	6
respiratory rate	6
therapeutic regimen	6
otros pacientes	6
para las	6
worse outcomes	6
dimer levels	6
population pharmacokinetics	6
tratamiento del	6
like sars	6
multiple organ	6
effective vaccine	6
influenza prevention	6
los riesgos	6
rna replication	6
loop diuretics	6
los procedimientos	6
several inflammatory	6
diferencias en	6
hydroxychloroquine despite	6
talento humano	6
treatment efficacy	6
potential risks	6
clinical findings	6
las pruebas	6
healthcare system	6
erythematosus due	6
travel medicine	6
retraso en	6
label design	6
orally administered	6
showed good	6
endothelial cell	6
como se	6
respondents reported	6
cursan con	6
evidencia directa	6
hace complex	6
docking analysis	6
wide spectrum	6
life support	6
april th	6
treatment assignment	6
much less	6
relacionados con	6
el coronavirus	6
good results	6
en lo	6
interindividual variability	6
studies using	6
based assays	6
surface area	6
del consentimiento	6
three cohorts	6
peer reviewed	6
del respirador	6
commonly reported	6
donde el	6
versus hcq	6
endosome fusion	6
gives emergency	6
potential mechanisms	6
reducing mortality	6
en donde	6
multifaceted effects	6
mechanisms underlying	6
en estudios	6
several drugs	6
data included	6
detectable viral	6
lung cancer	6
como lo	6
english language	6
los factores	6
patient care	6
permits use	6
proinflammatory signalling	6
four patients	6
early pregnancy	6
drug response	6
cell therapy	6
prospective observational	6
ltec values	6
possible treatment	6
situation report	6
potent inhibitors	6
falla cardiaca	6
towards optimization	6
immunomodulatory activity	6
close monitoring	6
data acquisition	6
fatal outcomes	6
un efecto	6
ifn response	6
respuesta inflamatoria	6
first week	6
especialmente en	6
paro cardiaco	6
cardiovascular adverse	6
cutting edge	6
many years	6
patients years	6
study demonstrated	6
extracellular traps	6
malformations associated	6
renal injury	6
analysis using	6
similar effect	6
son el	6
pulmonar en	6
en general	6
intracellular iron	6
score matching	6
literature search	6
recibieron tcz	6
esta estrategia	6
pulseless electrical	6
research project	6
como tratamiento	6
mg dose	6
day hcq	6
outpatient treatment	6
espacio muerto	6
neither hcq	6
plaquenil smpc	6
biological parameters	6
embo molecular	6
alanine metabolite	6
financial support	6
safe dose	6
prolongation ms	6
severidad del	6
potential benefits	6
possible mechanism	6
interim analysis	6
showed clinical	6
king county	6
evidence regarding	6
potential duration	6
antiretroviral therapy	6
nlrp inflammasome	6
hcq sulfate	6
plasma ratio	6
prolongation among	6
el volumen	6
institutional policy	6
con aumento	6
contra para	6
received remdesivir	6
care group	6
drug candidates	6
likely due	6
high prevalence	6
small studies	6
higher hcq	6
requiring oxygen	6
hiv aids	6
forest plot	6
signaling pathways	6
lower bound	6
potential therapies	6
con menor	6
interval monitoring	6
systematically searched	6
develop severe	6
evaluated using	6
upper bound	6
one week	6
asociada con	6
terapia en	6
findings may	6
el covid	6
renal elimination	6
electrical activity	6
fipv replication	6
molecular descriptors	6
analysis hydroxychloroquine	6
reportaron una	6
laboratory data	6
medications used	6
clinical factors	6
chronic diseases	6
con resultados	6
elevated troponin	6
hydroxychloroquine levels	6
six studies	6
esto se	6
acute phase	6
pp ab	6
docking results	6
series analysis	6
interferon genes	6
novel sars	6
gov identifier	6
safety surveillance	6