This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.
trigram | frequency |
---|---|
in patients with | 619 |
the treatment of | 442 |
patients with covid | 441 |
treatment of covid | 377 |
cq and hcq | 356 |
severe acute respiratory | 289 |
for the treatment | 281 |
acute respiratory syndrome | 265 |
the use of | 263 |
respiratory syndrome coronavirus | 228 |
chloroquine and hydroxychloroquine | 196 |
display the preprint | 191 |
who has granted | 191 |
license to display | 191 |
medrxiv a license | 191 |
the preprint in | 191 |
to display the | 191 |
has granted medrxiv | 191 |
hydroxychloroquine and azithromycin | 191 |
a license to | 191 |
granted medrxiv a | 191 |
in the treatment | 189 |
of hydroxychloroquine in | 184 |
the copyright holder | 184 |
the risk of | 183 |
copyright holder for | 179 |
holder for this | 179 |
systemic lupus erythematosus | 176 |
the author funder | 170 |
is the author | 170 |
as well as | 159 |
this version posted | 157 |
of patients with | 155 |
preprint in perpetuity | 154 |
with or without | 153 |
a systematic review | 148 |
patients treated with | 146 |
is made available | 145 |
of cq and | 144 |
for this preprint | 143 |
it is made | 141 |
made available under | 141 |
available under a | 141 |
international license it | 139 |
license it is | 139 |
en pacientes con | 138 |
treated with hcq | 133 |
of hydroxychloroquine and | 130 |
randomized clinical trial | 128 |
hospitalized patients with | 120 |
in combination with | 120 |
use of hcq | 118 |
patients with severe | 114 |
pacientes con covid | 113 |
of chloroquine and | 112 |
under a is | 111 |
a is the | 111 |
hcq and cq | 109 |
the effect of | 109 |
of severe acute | 108 |
this preprint this | 108 |
preprint this version | 108 |
due to the | 108 |
which was not | 103 |
hydroxychloroquine in patients | 102 |
of hcq in | 99 |
of hcq and | 98 |
in hospitalized patients | 98 |
with severe covid | 96 |
efficacy and safety | 95 |
of cq hcq | 95 |
of action of | 93 |
certified by peer | 91 |
by peer review | 91 |
not certified by | 91 |
was not certified | 91 |
of these drugs | 90 |
el uso de | 89 |
as a treatment | 89 |
intensive care unit | 88 |
systematic review and | 87 |
cq or hcq | 85 |
and safety of | 84 |
in this study | 83 |
effect of hcq | 83 |
for treatment of | 82 |
respiratory distress syndrome | 81 |
de los pacientes | 80 |
was associated with | 78 |
acute respiratory distress | 78 |
in order to | 77 |
the control group | 77 |
in the hcq | 76 |
critically ill patients | 76 |
a total of | 75 |
in treatment of | 75 |
followed by mg | 75 |
is associated with | 75 |
treatment of severe | 75 |
one of the | 75 |
the combination of | 74 |
p r e | 74 |
o o f | 73 |
a l p | 73 |
j o u | 73 |
u r n | 73 |
it has been | 73 |
r n a | 73 |
l p r | 73 |
p r o | 73 |
n a l | 73 |
o u r | 73 |
use of hydroxychloroquine | 73 |
r o o | 73 |
associated with a | 72 |
treated with hydroxychloroquine | 72 |
a treatment of | 72 |
the efficacy of | 72 |
mechanism of action | 70 |
effects of chloroquine | 70 |
based on the | 70 |
mg twice daily | 69 |
and azithromycin as | 69 |
review and meta | 69 |
dose of mg | 69 |
been shown to | 68 |
with coronavirus disease | 68 |
azithromycin as a | 67 |
and azithromycin in | 67 |
efficacy of hydroxychloroquine | 66 |
results of an | 66 |
a combination of | 66 |
in vitro antiviral | 66 |
for patients with | 66 |
patients in the | 65 |
hydroxychloroquine and chloroquine | 65 |
included in the | 64 |
this article is | 64 |
increased risk of | 64 |
of the patients | 64 |
of an open | 63 |
all rights reserved | 63 |
vitro antiviral activity | 63 |
los pacientes con | 63 |
or in combination | 63 |
con sospecha o | 63 |
qt interval prolongation | 63 |
of hydroxychloroquine for | 63 |
the qt interval | 62 |
a randomized clinical | 62 |
hydroxychloroquine for the | 62 |
alone or in | 60 |
there was no | 60 |
of coronavirus disease | 60 |
of the disease | 60 |
east respiratory syndrome | 59 |
results of a | 59 |
to evaluate the | 58 |
the time of | 58 |
middle east respiratory | 58 |
study of hydroxychloroquine | 58 |
torsade de pointes | 57 |
treatment with hydroxychloroquine | 57 |
the management of | 57 |
patients with coronavirus | 56 |
in vitro and | 56 |
the efficacy and | 55 |
mild to moderate | 55 |
ill patients with | 55 |
review of the | 55 |
antiviral activity and | 55 |
the number of | 55 |
world health organization | 55 |
mechanisms of action | 54 |
the context of | 54 |
the role of | 54 |
the effects of | 54 |
in the control | 54 |
dosing design of | 53 |
of optimized dosing | 53 |
design of hydroxychloroquine | 53 |
with systemic lupus | 53 |
projection of optimized | 53 |
the hcq group | 53 |
en los pacientes | 53 |
of the study | 53 |
and projection of | 53 |
optimized dosing design | 53 |
standard of care | 53 |
activity and projection | 53 |
hcq with or | 52 |
for coronavirus disease | 52 |
version posted june | 52 |
en el paciente | 52 |
combination of hydroxychloroquine | 52 |
with hydroxychloroquine and | 52 |
hcq in covid | 51 |
randomized controlled trial | 51 |
treatment with hcq | 51 |
efficacy of hcq | 51 |
treatment of patients | 50 |
and hydroxychloroquine in | 50 |
has been shown | 50 |
use of cq | 49 |
at the time | 49 |
infection in vitro | 49 |
protected by copyright | 49 |
de pacientes con | 49 |
is protected by | 49 |
the presence of | 49 |
article is protected | 49 |
the results of | 49 |
mortality in patients | 49 |
in systemic lupus | 49 |
or without azithromycin | 49 |
with rheumatoid arthritis | 49 |
hcq has been | 48 |
to assess the | 48 |
patients with sars | 48 |
of novel coronavirus | 48 |
gautret et al | 48 |
in the context | 48 |
and hcq in | 48 |
according to the | 47 |
in addition to | 47 |
combination with azithromycin | 47 |
compared to the | 47 |
in inhibiting sars | 47 |
antiviral activity of | 46 |
the absence of | 46 |
patients infected with | 46 |
was used to | 46 |
antiviral effects of | 46 |
no significant difference | 45 |
and hcq are | 45 |
systematic review of | 45 |
found to be | 45 |
the united states | 45 |
used in the | 45 |
in terms of | 45 |
of qtc prolongation | 44 |
of a randomized | 44 |
effects of hcq | 44 |
observational study of | 44 |
hydroxychloroquine in hospitalized | 44 |
no evidence of | 44 |
risk of bias | 44 |
were treated with | 44 |
risk factors for | 43 |
has been reported | 43 |
the fact that | 43 |
of hcq on | 43 |
the lack of | 43 |
de la enfermedad | 43 |
daily for days | 42 |
safety and efficacy | 42 |
treatment for covid | 42 |
el riesgo de | 42 |
on the other | 42 |
patients with rheumatoid | 42 |
vitro and in | 41 |
effective in inhibiting | 41 |
a less toxic | 41 |
patients hospitalized with | 41 |
twice daily for | 41 |
effectively inhibit the | 40 |
higher risk of | 40 |
the antiviral effects | 40 |
hospitalized with covid | 40 |
the recently emerged | 40 |
derivative of chloroquine | 40 |
qt prolongation and | 40 |
of the drugs | 40 |
in new york | 40 |
emerged novel coronavirus | 40 |
there is no | 40 |
torsades de pointes | 40 |
vero e cells | 40 |
retrospective cohort study | 40 |
remdesivir and chloroquine | 40 |
the host cell | 40 |
in clinical studies | 40 |
inhibit the recently | 39 |
dose of hcq | 39 |
the other hand | 39 |
associated pneumonia in | 39 |
and chloroquine effectively | 39 |
less toxic derivative | 39 |
clinical characteristics of | 39 |
toxic derivative of | 39 |
chloroquine effectively inhibit | 39 |
is effective in | 39 |
effect of hydroxychloroquine | 39 |
recently emerged novel | 39 |
of the drug | 39 |
in critically ill | 38 |
as compared to | 38 |
used to treat | 38 |
of the virus | 38 |
of treatment with | 38 |
has shown apparent | 37 |
and in vivo | 37 |
patients with systemic | 37 |
use of chloroquine | 37 |
combination of hcq | 37 |
apparent efficacy in | 37 |
of critically ill | 37 |
the development of | 37 |
the two groups | 37 |
small sample size | 37 |
shown apparent efficacy | 37 |
pneumonia in clinical | 37 |
efficacy in treatment | 37 |
se recomienda no | 37 |
food and drug | 37 |
chloroquine phosphate has | 36 |
en el grupo | 36 |
there is a | 36 |
for this this | 36 |
preprint the copyright | 36 |
this this version | 36 |
the novel coronavirus | 36 |
both cq and | 36 |
between the two | 36 |
the present study | 36 |
and drug administration | 36 |
systematic reviews and | 36 |
and treatment of | 36 |
was found to | 36 |
in patients treated | 36 |
the need for | 36 |
pharmacokinetics of hydroxychloroquine | 36 |
phosphate has shown | 36 |
clinical efficacy of | 36 |
effect of chloroquine | 36 |
patients with mild | 36 |
in the study | 36 |
version posted november | 36 |
of chloroquine on | 36 |
hospitalized with severe | 35 |
hcq and azithromycin | 35 |
qt interval in | 35 |
with severe acute | 35 |
has also been | 35 |
hydroxychloroquine in the | 35 |
effects of cq | 35 |
of hospitalized patients | 35 |
and efficacy of | 34 |
de la salud | 34 |
in a patient | 34 |
a patient with | 34 |
hcq and rfifn | 34 |
of qt interval | 34 |
hydroxychloroquine with or | 34 |
in vitro studies | 34 |
tumor necrosis factor | 34 |
of clinical trials | 34 |
used for the | 34 |
a retrospective cohort | 34 |
a dose of | 34 |
significant difference in | 33 |
the inhibition of | 33 |
effect of a | 33 |
version posted may | 33 |
supplementary table s | 33 |
type i ifn | 33 |
time to clinical | 33 |
than that of | 33 |
of this study | 33 |
the incidence of | 33 |
with at least | 33 |
not associated with | 33 |
the mechanism of | 33 |
in patients hospitalized | 33 |
infected with sars | 32 |
any of the | 32 |
for cq and | 32 |
the replication of | 32 |
shown to be | 32 |
risk of qt | 32 |
of the viral | 32 |
novel coronavirus pneumonia | 32 |
el manejo de | 32 |
most of the | 32 |
the case of | 32 |
treatment of sars | 32 |
an increase in | 32 |
of the included | 32 |
side effects of | 32 |
hcq in the | 32 |
it should be | 32 |
patients receiving hcq | 31 |
the expression of | 31 |
human immunodeficiency virus | 31 |
role in the | 31 |
with novel coronavirus | 31 |
pacientes con sospecha | 31 |
of hcq is | 31 |
during the covid | 31 |
the most common | 31 |
and hcq have | 31 |
the world health | 31 |
the effectiveness of | 31 |
the intensive care | 31 |
interval in patients | 31 |
of the literature | 31 |
action of hydroxychloroquine | 31 |
the production of | 30 |
number of patients | 30 |
la presencia de | 30 |
in rheumatoid arthritis | 30 |
potent inhibitor of | 30 |
azithromycin in covid | 30 |
an increased risk | 30 |
with the combination | 30 |
has not been | 30 |
the viral load | 30 |
of cq or | 30 |
yao et al | 30 |
se recomienda la | 30 |
on the efficacy | 30 |
the first day | 30 |
the rate of | 30 |
with hcq and | 30 |
mg per day | 30 |
in the early | 30 |
involved in the | 30 |
a randomized trial | 30 |
have been reported | 30 |
the activation of | 30 |
was defined as | 30 |
hospital mortality in | 30 |
use of these | 30 |
the safety of | 29 |
outcomes of hydroxychloroquine | 29 |
rheumatoid arthritis and | 29 |
increase the risk | 29 |
at least a | 29 |
of hcq was | 29 |
clinical trials are | 29 |
at a dose | 29 |
of a combination | 29 |
activity against sars | 29 |
the majority of | 29 |
in the absence | 29 |
randomized controlled trials | 29 |
to treat covid | 29 |
there are no | 29 |
have shown that | 29 |
in clinical trials | 29 |
mg daily for | 28 |
randomized clinical trials | 28 |
the severe acute | 28 |
or clinical benefit | 28 |
with the use | 28 |
de cuidados intensivos | 28 |
randomised controlled trial | 28 |
due to its | 28 |
with use of | 28 |
prophylaxis for covid | 28 |
management of covid | 28 |
least a six | 28 |
of the studies | 28 |
patients with at | 28 |
patients who received | 28 |
well as the | 28 |
los pacientes que | 28 |
there was a | 28 |
to clinical improvement | 28 |
day follow up | 28 |
in severe covid | 28 |
in the lung | 28 |
association of treatment | 28 |
reviews and meta | 28 |
in the united | 28 |
the duration of | 27 |
of the sars | 27 |
the coronavirus disease | 27 |
inhibitor of sars | 27 |
the immune system | 27 |
safety of hcq | 27 |
is important to | 27 |
clearance or clinical | 27 |
of sars coronavirus | 27 |
increase in the | 27 |
series of patients | 27 |
the impact of | 27 |
of hydroxychloroquine with | 27 |
a higher risk | 27 |
been reported to | 27 |
evidence for the | 27 |
emergency use authorization | 27 |
conflict of interest | 27 |
of hcq with | 27 |
a pilot study | 27 |
related to the | 27 |
effect of cq | 27 |
as shown in | 27 |
as adjunctive therapy | 27 |
microbiological effect of | 26 |
the course of | 26 |
with hydroxychloroquine or | 26 |
of chloroquine against | 26 |
chloroquine or hydroxychloroquine | 26 |
this study was | 26 |
drugs in the | 26 |
viral shedding duration | 26 |
there were no | 26 |
who received hcq | 26 |
hydroxychloroquine or azithromycin | 26 |
benefit with the | 26 |
in treating covid | 26 |
or azithromycin with | 26 |
have also been | 26 |
a novel coronavirus | 26 |
a potent inhibitor | 26 |
to the control | 26 |
effects of hydroxychloroquine | 26 |
version posted july | 26 |
need to be | 26 |
it is important | 26 |
and microbiological effect | 26 |
to have a | 26 |
compared to those | 26 |
mode of action | 26 |
studies have shown | 26 |
azithromycin in patients | 26 |
in vitro activity | 26 |
evidence of rapid | 26 |
associated with the | 26 |
clinical and microbiological | 26 |
some of the | 26 |
patients who were | 26 |
of the treatment | 26 |
controlled clinical trials | 25 |
wang et al | 25 |
in animal models | 25 |
new york state | 25 |
the qtc interval | 25 |
per day for | 25 |
chloroquine is a | 25 |
in the management | 25 |
in light of | 25 |
hcq in patients | 25 |
a number of | 25 |
of hydroxychloroquine on | 25 |
the safety and | 25 |
be associated with | 25 |
these drugs in | 25 |
as a result | 25 |
associated with use | 25 |
clinical benefit with | 25 |
treated with cq | 25 |
was no significant | 25 |
qtc prolongation in | 25 |
antiviral clearance or | 25 |
have been shown | 25 |
in the case | 25 |
chloroquine for the | 25 |
shown in figure | 25 |
showed that the | 25 |
a case series | 25 |
azithromycin with in | 25 |
were included in | 25 |
the antiviral activity | 25 |
of rapid antiviral | 25 |
rapid antiviral clearance | 25 |
in a recent | 25 |
the possibility of | 24 |
a pilot observational | 24 |
a review of | 24 |
patients with a | 24 |
of the data | 24 |
case series of | 24 |
and hydroxychloroquine as | 24 |
an old drug | 24 |
has been used | 24 |
trial of hydroxychloroquine | 24 |
the release of | 24 |
moderate coronavirus disease | 24 |
sars coronavirus infection | 24 |
pilot observational study | 24 |
teniendo en cuenta | 24 |
congestive heart failure | 24 |
the end of | 24 |
the ph of | 24 |
on the use | 24 |
was not associated | 24 |
hydroxychloroquine or chloroquine | 24 |
analysis of the | 24 |
a randomized controlled | 24 |
to be effective | 24 |
the original paper | 24 |
cases of covid | 24 |
who did not | 23 |
of hydroxychloroquine as | 23 |
associated with an | 23 |
implications for rheumatology | 23 |
the study was | 23 |
serious adverse events | 23 |
and rheumatoid arthritis | 23 |
the primary outcome | 23 |
with mild to | 23 |
prolongation associated with | 23 |
cq hcq in | 23 |
been associated with | 23 |
due to covid | 23 |
treatment of malaria | 23 |
it is also | 23 |
hcq alone or | 23 |
for the management | 23 |
coronavirus infection and | 23 |
hcq and az | 23 |
of hcq for | 23 |
recomienda no utilizar | 23 |
of hcq to | 23 |
should not be | 23 |
para el manejo | 23 |
activation of the | 23 |
not included in | 23 |
paciente con sospecha | 23 |
infection treated with | 23 |
in vitro in | 23 |
during the first | 23 |
novel coronavirus in | 23 |
between hcq and | 23 |
risk of adverse | 23 |
did not show | 23 |
cov and sars | 23 |
activity of cq | 23 |
of convalescent plasma | 23 |
acute lung injury | 23 |
pilot study of | 23 |
of the hcq | 23 |
of patients infected | 22 |
was not peer | 22 |
institutional review board | 22 |
study of patients | 22 |
in this review | 22 |
patients testing positive | 22 |
hcq have been | 22 |
cq has been | 22 |
was observed in | 22 |
the severity of | 22 |
inhibition of the | 22 |
hydroxychloroquine in treatment | 22 |
in the covid | 22 |
we did not | 22 |
the included studies | 22 |
in patients receiving | 22 |
of adverse events | 22 |
el grupo de | 22 |
hospitalized for covid | 22 |
effects of the | 22 |
en caso de | 22 |
use in covid | 22 |
associated with hcq | 22 |
is a potent | 22 |
infection and spread | 22 |
mg kg day | 22 |
therapy for patients | 22 |
of chloroquine in | 22 |
the in vitro | 22 |
difference in the | 22 |
data from the | 22 |
as a potential | 22 |
appears to be | 22 |
se recomienda que | 22 |
in the present | 21 |
of the covid | 21 |
of this drug | 21 |
qt interval and | 21 |
to be a | 21 |
a recent study | 21 |
a reduction in | 21 |
el paciente con | 21 |
none of the | 21 |
corrected qt interval | 21 |
are needed to | 21 |
factors associated with | 21 |
action of cq | 21 |
that of the | 21 |
mortality in covid | 21 |
of the two | 21 |
testing positive for | 21 |
risk of death | 21 |
patients with acute | 21 |
and outcomes of | 21 |
of the qt | 21 |
of systemic lupus | 21 |
of qt prolongation | 21 |
ongoing clinical trials | 21 |
due to their | 21 |
chloroquine and hcq | 21 |
la necesidad de | 21 |
risk of mortality | 21 |
and systemic lupus | 21 |
a clinical trial | 21 |
day for days | 21 |
of the pandemic | 21 |
a retrospective analysis | 21 |
resulted in a | 21 |
in hospitalized covid | 21 |
to reduce the | 21 |
of severe covid | 21 |
of observational studies | 21 |
to moderate coronavirus | 21 |
hydroxychloroquine in covid | 21 |
diseases such as | 21 |
that there was | 21 |
connective tissue diseases | 21 |
and in the | 21 |
of chloroquine diphosphate | 21 |
and mortality in | 20 |
were found to | 20 |
hcq for the | 20 |
interval prolongation associated | 20 |
a narrative review | 20 |
the authors declare | 20 |
no significant differences | 20 |
hcq or cq | 20 |
showed that hcq | 20 |
of rheumatoid arthritis | 20 |
among hospitalized patients | 20 |
hydroxychloroquine usage in | 20 |
in adults hospitalized | 20 |
of the first | 20 |
a author funder | 20 |
course of covid | 20 |
results showed that | 20 |
doses of hcq | 20 |
was performed using | 20 |
has been demonstrated | 20 |
usage in united | 20 |
is based on | 20 |
in the first | 20 |
united states veterans | 20 |
viral load in | 20 |
the outcome of | 20 |
to our knowledge | 20 |
patients with mainly | 20 |
hcq was associated | 20 |
in united states | 20 |
was used for | 20 |
associated with increased | 20 |
seems to be | 20 |
patients hospitalized for | 20 |
veterans hospitalized with | 20 |
mainly mild to | 20 |
type i interferon | 20 |
states veterans hospitalized | 20 |
adverse effects of | 20 |
el tratamiento de | 20 |
significant effect of | 20 |
early treatment of | 20 |
it is not | 20 |
drugs have been | 20 |
be due to | 20 |
of antimalarial drugs | 20 |
pneumonia in wuhan | 20 |
el inicio de | 20 |
morbidity and mortality | 20 |
with respect to | 20 |
on patients with | 20 |
under a author | 20 |
of lopinavir ritonavir | 20 |
approved by the | 20 |
of hydroxychloroquine usage | 20 |
with hydroxychloroquine azithromycin | 20 |
an observational study | 20 |
with mainly mild | 20 |
of chloroquine for | 20 |
activity of hcq | 20 |
of torsade de | 19 |
could not be | 19 |
del paciente con | 19 |
en un estudio | 19 |
prophylactic and therapeutic | 19 |
that the use | 19 |
for the prevention | 19 |
use authorization for | 19 |
diphosphate as adjunctive | 19 |
chloroquine on viral | 19 |
administration of hcq | 19 |
sudden cardiac death | 19 |
can be used | 19 |
of hydroxychloroquine sulfate | 19 |
needs to be | 19 |
combination with other | 19 |
adjunctive therapy for | 19 |
concomitant azithromycin among | 19 |
should be noted | 19 |
feline infectious peritonitis | 19 |
for mechanical ventilation | 19 |
are associated with | 19 |
and azithromycin on | 19 |
of type i | 19 |
as a prophylactic | 19 |
of patients were | 19 |
mg bid for | 19 |
de la uci | 19 |
or hcq with | 19 |
hospitalized patients testing | 19 |
pacientes con sdra | 19 |
such as the | 19 |
hcq use in | 19 |
caused by the | 19 |
the treatment group | 19 |
old drug against | 19 |
is one of | 19 |
azithromycin among hospitalized | 19 |
prolongation of the | 19 |
significant differences in | 19 |
chloroquine diphosphate as | 19 |
to inhibit the | 19 |
in coronavirus disease | 19 |
therapy in covid | 19 |
on viral infections | 19 |
each of the | 19 |
of cq in | 19 |
or without concomitant | 19 |
with azithromycin in | 19 |
cardiac side effects | 19 |
without concomitant azithromycin | 19 |
in the liver | 19 |
for patients hospitalized | 19 |
lupus erythematosus and | 19 |
in accordance with | 19 |
also been reported | 19 |
vitro in vitro | 19 |
compared with the | 19 |
were observed in | 19 |
the findings of | 19 |
the availability of | 19 |
novel coronavirus disease | 19 |
de pointes in | 19 |
por lo tanto | 19 |
positive for coronavirus | 19 |
no utilizar de | 18 |
glycosylation of ace | 18 |
low doses of | 18 |
hcq did not | 18 |
paciente con covid | 18 |
lower than that | 18 |
the prevention of | 18 |
and qt prolongation | 18 |
in the high | 18 |
for systematic reviews | 18 |
as postexposure prophylaxis | 18 |
on the first | 18 |
no conflict of | 18 |
t cells and | 18 |
coronary artery disease | 18 |
be used to | 18 |
the comparison group | 18 |
doses of chloroquine | 18 |
with a macrolide | 18 |
en el tratamiento | 18 |
reported to be | 18 |
the occurrence of | 18 |
of lpv r | 18 |
of these studies | 18 |
a trial of | 18 |
qtc prolongation and | 18 |
because of the | 18 |
by mg twice | 18 |
by hcq and | 18 |
the viral shedding | 18 |
used as a | 18 |
to be more | 18 |
conflicts of interest | 18 |
controlled trial of | 18 |
to moderate covid | 18 |
a cohort of | 18 |
randomized trial of | 18 |
vitro activity against | 18 |
acute respiratory failure | 18 |
to investigate the | 18 |
days of treatment | 18 |
risk of qtc | 18 |
of the most | 18 |
were used to | 18 |
of high vs | 18 |
in vitro inhibition | 18 |
cq and or | 18 |
included in this | 18 |
the binding energy | 18 |
reduction in the | 18 |
for disease control | 18 |
responsible for the | 18 |
effect of high | 18 |
volume of distribution | 18 |
when compared to | 18 |
with rheumatic diseases | 18 |
se recomienda en | 18 |
were performed using | 18 |
ischemic heart disease | 18 |
from patients with | 18 |
polymerase chain reaction | 18 |
are shown in | 18 |
with hcq or | 18 |
preferred reporting items | 18 |
cytokine release syndrome | 18 |
in a study | 18 |
del estado de | 18 |
a retrospective study | 18 |
is mediated by | 18 |
in intensive care | 18 |
efficacy of cq | 18 |
clinical features of | 18 |
a variety of | 18 |
nature of the | 18 |
reporting items for | 18 |
the quality of | 18 |
in our study | 18 |
in vero e | 18 |
and or hcq | 18 |
it is possible | 18 |
large number of | 18 |
analyses were performed | 18 |
the control arm | 18 |
de forma rutinaria | 18 |
of hcq as | 18 |
with acute respiratory | 18 |
the association between | 18 |
clinical trials have | 18 |
de alto flujo | 18 |
the treatment and | 18 |
obtained from the | 17 |
to note that | 17 |
significant difference between | 17 |
safety of hydroxychloroquine | 17 |
the association of | 17 |
vitro inhibition of | 17 |
hydroxychloroquine as postexposure | 17 |
cardiac complications attributed | 17 |
effect of the | 17 |
significant reduction in | 17 |
inicio de los | 17 |
the time to | 17 |
the level of | 17 |
common coronavirus disease | 17 |
de acuerdo con | 17 |
the s protein | 17 |
its ability to | 17 |
to determine the | 17 |
of hcq use | 17 |
has been proposed | 17 |
mediated by the | 17 |
several clinical trials | 17 |
in the hippocampus | 17 |
the need to | 17 |
study showed that | 17 |
reported in the | 17 |
trial of lopinavir | 17 |
for the use | 17 |
clinical course and | 17 |
savarino et al | 17 |
the hcq arm | 17 |
a series of | 17 |
with common coronavirus | 17 |
in the current | 17 |
of the immune | 17 |
these drugs are | 17 |
patients with rheumatic | 17 |
e qt ratio | 17 |
in patients who | 17 |
de la terapia | 17 |
in vitro data | 17 |
insights into the | 17 |
patients with novel | 17 |
patients with common | 17 |
total of patients | 17 |
associated with lower | 17 |
to that of | 17 |
be noted that | 17 |
extracorporeal membrane oxygenation | 17 |
with lopinavir ritonavir | 17 |
long qt syndrome | 17 |
of patients in | 17 |
of hcq or | 17 |
a significant effect | 17 |
and risk factors | 17 |
in the risk | 17 |
the addition of | 17 |
a result of | 17 |
results of the | 17 |
with cq and | 17 |
complications attributed to | 17 |
cq hcq may | 17 |
of viral rna | 17 |
we found that | 17 |
proportion of patients | 17 |
lower respiratory tract | 17 |
have not been | 17 |
be used in | 17 |
analysis was performed | 17 |
m a n | 17 |
an intensive care | 17 |
interval prolongation in | 17 |
been reported in | 17 |
such as systemic | 17 |
of adverse effects | 17 |
adults hospitalized with | 17 |
of mg twice | 17 |
hydroxychloroquine for covid | 17 |
inhibition of human | 17 |
compassionate use of | 17 |
hcq for covid | 17 |
or without a | 17 |
systematic review on | 16 |
there is an | 16 |
in the meta | 16 |
considered to be | 16 |
that in the | 16 |
geleris et al | 16 |
have been proposed | 16 |
treatments for coronavirus | 16 |
been reported that | 16 |
si el paciente | 16 |
prophylaxis of covid | 16 |
vincent et al | 16 |
is known to | 16 |
in a case | 16 |
treatment of novel | 16 |
have been used | 16 |
the corrected qt | 16 |
of hcq treatment | 16 |
it is a | 16 |
of the original | 16 |
showed that cq | 16 |
did not receive | 16 |
high vs low | 16 |
viral replication and | 16 |
y cols en | 16 |
vs low doses | 16 |
on the basis | 16 |
a case report | 16 |
with and without | 16 |
u s c | 16 |
which is a | 16 |
in of patients | 16 |
postexposure prophylaxis for | 16 |
with regard to | 16 |
treated with a | 16 |
the disease course | 16 |
hcq may be | 16 |
interval prolongation and | 16 |
observed in the | 16 |
no reuse allowed | 16 |
in the original | 16 |
in these patients | 16 |
need for mechanical | 16 |
the strength of | 16 |
day followed by | 16 |
a multinational registry | 16 |
absence of a | 16 |
to the intensive | 16 |
multinational registry analysis | 16 |
fuerte a favor | 16 |
data on the | 16 |
at least one | 16 |
with qtc prolongation | 16 |
s c r | 16 |
duration of treatment | 16 |
of patients had | 16 |
prolonged qt interval | 16 |
was shown to | 16 |
r i p | 16 |
uso de la | 16 |
that cq and | 16 |
in the presence | 16 |
c r i | 16 |
should be taken | 16 |
of hcq azm | 16 |
the basis of | 16 |
on the antiviral | 16 |
de cuidado intensivo | 16 |
a n u | 16 |
high risk of | 16 |
there have been | 16 |
be related to | 16 |
the proportion of | 16 |
allowed without permission | 16 |
n u s | 16 |
ritonavir in adults | 16 |
the pharmacokinetics of | 16 |
virus infection in | 16 |
retrospective analysis of | 16 |
of the s | 16 |
replication of sars | 16 |
clinical management of | 16 |
the cardiovascular system | 16 |
admitted to the | 16 |
a report of | 16 |
control and prevention | 16 |
the frequency of | 16 |
reuse allowed without | 16 |
terminal glycosylation of | 16 |
that they have | 16 |
i p t | 16 |
or hcq in | 16 |
into host cells | 16 |
increase in qtc | 16 |
is the most | 16 |
for chloroquine and | 16 |
a new coronavirus | 15 |
a lack of | 15 |
intubation or death | 15 |
in healthy volunteers | 15 |
that there is | 15 |
to be the | 15 |
of the participants | 15 |
been used for | 15 |
are involved in | 15 |
association between hcq | 15 |
safety of cq | 15 |
action of chloroquine | 15 |
what to expect | 15 |
unidad de cuidados | 15 |
a favor fundamento | 15 |
interfere with the | 15 |
been shown that | 15 |
without a macrolide | 15 |
of these patients | 15 |
in vitro study | 15 |
cd t cells | 15 |
insights on the | 15 |
be effective in | 15 |
to be safe | 15 |
binding of the | 15 |
hcq combined with | 15 |
national institutes of | 15 |
with other drugs | 15 |
either cq or | 15 |
as systemic lupus | 15 |
patients were treated | 15 |
se recomienda realizar | 15 |
ingreso a uci | 15 |
the beginning of | 15 |
to examine the | 15 |
added to the | 15 |
studies have been | 15 |
entry into host | 15 |
of hospital stay | 15 |
as a therapeutic | 15 |
with hcq alone | 15 |
in line with | 15 |
by interfering with | 15 |
daily measured qtc | 15 |
those treated with | 15 |
of patients who | 15 |
no se puede | 15 |
have been identified | 15 |
in the prevention | 15 |
disease control and | 15 |
adult patients with | 15 |
an in vitro | 15 |
the binding of | 15 |
is the first | 15 |
found that the | 15 |
presented in table | 15 |
it can be | 15 |
effect on the | 15 |
differences in the | 15 |
la toma de | 15 |
in agreement with | 15 |
ace and tmprss | 15 |
associated with covid | 15 |
cohort study of | 15 |
una serie de | 15 |
part of the | 15 |
safe and effective | 15 |
and hcq is | 15 |
ra and sle | 15 |
prevention of covid | 15 |
hcq or hcq | 15 |
risk of cardiovascular | 15 |
the solidarity trial | 15 |
the mrna expression | 15 |
longest daily measured | 15 |
the included reviews | 15 |
liu et al | 15 |
the ability of | 15 |
and hcq for | 15 |
use of remdesivir | 15 |
azithromycin in the | 15 |
qtc interval prolongation | 15 |
end of the | 15 |
a pesar de | 15 |
analysis of cases | 15 |
this study is | 15 |
modifying antirheumatic drugs | 15 |
the viral replication | 15 |
in relation to | 15 |
for the covid | 15 |
clinical course of | 15 |
the updated meta | 15 |
to the icu | 15 |
no se ha | 15 |
pharmacologic treatments for | 15 |
the study by | 15 |
has been associated | 15 |
to be associated | 15 |
followed by a | 15 |
influenza a virus | 15 |
the influence of | 15 |
or without az | 15 |
a history of | 14 |
expect for covid | 14 |
a mouse model | 14 |
treatments for covid | 14 |
and torsade de | 14 |
may not be | 14 |
lpv r and | 14 |
treatment options for | 14 |
the reduction of | 14 |
cases in marseille | 14 |
of remdesivir in | 14 |
items for systematic | 14 |
the pbs group | 14 |
favor o en | 14 |
to chloroquine and | 14 |
a macrolide for | 14 |
and hcq with | 14 |
replication in vitro | 14 |
macrolide for treatment | 14 |
infected with novel | 14 |
low dose of | 14 |
chloroquine against coronavirus | 14 |
higher than the | 14 |
cq hcq have | 14 |
this is a | 14 |
label use of | 14 |
and management of | 14 |
clinical trial hydroxychloroquine | 14 |
up to days | 14 |
by mg daily | 14 |
or chloroquine with | 14 |
showed no significant | 14 |
was conducted to | 14 |
assessment of qt | 14 |
a favor o | 14 |
that have been | 14 |
patients admitted to | 14 |
to expect for | 14 |
of the qtc | 14 |
studies on the | 14 |
and risk of | 14 |
in vivo studies | 14 |
a global pandemic | 14 |
manejo de la | 14 |
for the novel | 14 |
of patients treated | 14 |
diagnosis and treatment | 14 |
found to have | 14 |
patients with hydroxychloroquine | 14 |
intervals in a | 14 |
was based on | 14 |
likely to be | 14 |
interpretation of the | 14 |
loading dose of | 14 |
effective and safe | 14 |
with a total | 14 |
two of the | 14 |
it may be | 14 |
inhibition of viral | 14 |
chloroquine with or | 14 |
should be considered | 14 |
clinical trials and | 14 |
with an increased | 14 |
of chloroquine or | 14 |
of cases in | 14 |
in case of | 14 |
infection with sars | 14 |
chen et al | 14 |
is required for | 14 |
and severe acute | 14 |
y en el | 14 |
pacientes en el | 14 |
significant qtc prolongation | 14 |
performed using the | 14 |
among patients with | 14 |
patients with diabetes | 14 |
of qt intervals | 14 |
is involved in | 14 |
hydroxychloroquine alone or | 14 |
patient with systemic | 14 |
is responsible for | 14 |
attributed to chloroquine | 14 |
to predict the | 14 |
more likely to | 14 |
corona virus disease | 14 |
the standard of | 14 |
hcq is a | 14 |
entry depends on | 14 |
la carga viral | 14 |
azithromycin on the | 14 |
in rheumatic diseases | 14 |
treatment of coronavirus | 14 |
associated with qtc | 14 |
that cq hcq | 14 |
coronavirus disease in | 14 |
as part of | 14 |
of hcq therapy | 14 |
in the lungs | 14 |
study was conducted | 14 |
and hydroxychloroquine for | 14 |
o en contra | 14 |
mg once daily | 14 |
with hydroxychloroquine alone | 14 |
fact that the | 14 |
the magnitude of | 14 |
of a study | 14 |
the glycosylation of | 14 |
new insights on | 14 |
hcq against sars | 14 |
the hcq treatment | 14 |
patients at risk | 14 |
induced qt prolongation | 14 |
into the host | 14 |
qt intervals in | 14 |
been used in | 14 |
difference between the | 14 |
and mechanical ventilation | 14 |
hydroxychloroquine and its | 14 |
risk factor for | 14 |
cq hcq are | 14 |
tlr and tlr | 14 |
severity of covid | 13 |
there has been | 13 |
servicios de salud | 13 |
that treatment with | 13 |
in cell culture | 13 |
infection and progression | 13 |
the relationship between | 13 |
of the coronavirus | 13 |
in the brain | 13 |
dependent rna polymerase | 13 |
a treatment for | 13 |
patients who did | 13 |
study of the | 13 |
on ace and | 13 |
with lower mortality | 13 |
associated with qt | 13 |
were more likely | 13 |
who require oxygen | 13 |
authors declare no | 13 |
de dificultad respiratoria | 13 |
to be used | 13 |
cytokine storm and | 13 |
recommendations for the | 13 |
course of the | 13 |
in another study | 13 |
we evaluated the | 13 |
in the usa | 13 |
and pharmacokinetics of | 13 |
for use of | 13 |
of the host | 13 |
been found to | 13 |
reported that the | 13 |
is blocked by | 13 |
routine care data | 13 |
los servicios de | 13 |
urgent need for | 13 |
antiviral activity against | 13 |
to compare the | 13 |
change in qtc | 13 |
a range of | 13 |
significantly associated with | 13 |
severely ill patients | 13 |
to estimate the | 13 |
onset of symptoms | 13 |
american college of | 13 |
of hcq has | 13 |
for prophylaxis of | 13 |
to fight covid | 13 |
of all the | 13 |
changes in the | 13 |
features of patients | 13 |
safety of chloroquine | 13 |
in some patients | 13 |
comparative study using | 13 |
the formation of | 13 |
depends on ace | 13 |
in an intensive | 13 |
dentro de las | 13 |
reduction of the | 13 |
with these drugs | 13 |
was obtained from | 13 |
outcomes in patients | 13 |
study using routine | 13 |
lopinavir ritonavir in | 13 |
and it is | 13 |
pneumonia who require | 13 |
calidad de vida | 13 |
effective in the | 13 |
with hcq was | 13 |
the spread of | 13 |
more common in | 13 |
of the infection | 13 |
treatment and prophylaxis | 13 |
critically ill covid | 13 |
important to note | 13 |
shortness of breath | 13 |
of middle east | 13 |
based on a | 13 |
using routine care | 13 |
light of the | 13 |
of the medications | 13 |
ability to inhibit | 13 |
lack of evidence | 13 |
infected with covid | 13 |
be used as | 13 |
patients with pneumonia | 13 |
these two drugs | 13 |
sars and mers | 13 |
the amount of | 13 |
were excluded from | 13 |
el tratamiento con | 13 |
small number of | 13 |
with convalescent plasma | 13 |
the spike protein | 13 |
ph of the | 13 |
with mild covid | 13 |
which this version | 13 |
azithromycin in an | 13 |
results of this | 13 |
yang et al | 13 |
which has been | 13 |
observational comparative study | 13 |
in a mouse | 13 |
of remdesivir for | 13 |
is possible that | 13 |
patients with chronic | 13 |
borba et al | 13 |
use of corticosteroids | 13 |
and cyp a | 13 |
a loading dose | 13 |
be explained by | 13 |
a role in | 13 |
clinical trials in | 13 |
flow nasal cannula | 13 |
the inclusion criteria | 13 |
review on the | 13 |
in a retrospective | 13 |
todos los pacientes | 13 |
arthritis and systemic | 13 |
three times daily | 13 |
for use in | 13 |
a and b | 13 |
prophylaxis and treatment | 13 |
have been published | 13 |
in the literature | 13 |
in the disease | 12 |
associated with reduced | 12 |
immunodeficiency virus type | 12 |
as a possible | 12 |
rheumatoid arthritis patients | 12 |
than cq in | 12 |
through the inhibition | 12 |
benefit of hcq | 12 |
in a randomized | 12 |
therapeutic efficacy of | 12 |
patients received hcq | 12 |
antiviral effect of | 12 |
an analysis of | 12 |
coronavirus in wuhan | 12 |
response to the | 12 |
central nervous system | 12 |
hydroxychloroquine as available | 12 |
erythematosus and rheumatoid | 12 |
defined as the | 12 |
the risk for | 12 |
in which the | 12 |
a reduction of | 12 |
that of cq | 12 |
weapons to fight | 12 |
chronic obstructive pulmonary | 12 |
la disponibilidad de | 12 |
risk of serious | 12 |
compared with placebo | 12 |
an urgent need | 12 |
mayor riesgo de | 12 |
new insights into | 12 |
outcomes of patients | 12 |
higher rate of | 12 |
similar to the | 12 |
for treating covid | 12 |
can result in | 12 |
lupus erythematosus patients | 12 |
the importance of | 12 |
en la uci | 12 |
the general population | 12 |
cell entry depends | 12 |
in subjects with | 12 |
patients on hcq | 12 |
characteristics of the | 12 |
patients were included | 12 |
in comparison with | 12 |
concomitant use of | 12 |
inhibition of sars | 12 |
disease severity and | 12 |
a control group | 12 |
puede emitir una | 12 |
majority of the | 12 |
were obtained from | 12 |
found in the | 12 |
during treatment of | 12 |
studies hydroxychloroquine and | 12 |
a dosis de | 12 |
are presented in | 12 |
of these medications | 12 |
result of the | 12 |
and the risk | 12 |
of hcq against | 12 |
of the manuscript | 12 |
this is the | 12 |
at the same | 12 |
its use in | 12 |
para el uso | 12 |
with a reduction | 12 |
and is blocked | 12 |
leads to the | 12 |
has been found | 12 |
viruses such as | 12 |
of azithromycin and | 12 |
study conducted in | 12 |
characteristics of coronavirus | 12 |
del paciente y | 12 |
we believe that | 12 |
the positive effect | 12 |
was approved by | 12 |
has been suggested | 12 |
en el manejo | 12 |
first case of | 12 |
available weapons to | 12 |
was significantly lower | 12 |
a large number | 12 |
for each of | 12 |
chloroquine in the | 12 |
use of the | 12 |
the activity of | 12 |
of action is | 12 |
and chloroquine in | 12 |
clinically proven protease | 12 |
in the included | 12 |
daily dose of | 12 |
by a clinically | 12 |
and tmprss and | 12 |
studies included in | 12 |
in association with | 12 |
the recovery trial | 12 |
prolongation and torsade | 12 |
se puede emitir | 12 |
hcq on the | 12 |
compared to patients | 12 |
beneficial effect of | 12 |
of hcq mono | 12 |
efficacy of these | 12 |
high dose of | 12 |
clinical trials for | 12 |
the differences in | 12 |
the spike glycoprotein | 12 |
safety profile of | 12 |
to standard care | 12 |
report of cases | 12 |
interfering with the | 12 |
efficacy of chloroquine | 12 |
of the evidence | 12 |
are weak bases | 12 |
without azithromycin in | 12 |
may have been | 12 |
that hcq has | 12 |
the percentage of | 12 |
clinical trials to | 12 |
tissue distribution of | 12 |
risk of cardiac | 12 |
in the plasma | 12 |
creative commons licence | 12 |
in the amygdala | 12 |
entry into the | 12 |
as long as | 12 |
that hcq is | 12 |
the preferred reporting | 12 |
as available weapons | 12 |
blocked by a | 12 |
either alone or | 12 |
personal de salud | 12 |
factores de riesgo | 12 |
a decrease in | 12 |
the two drugs | 12 |
los pacientes en | 12 |
did not have | 12 |
a clinically proven | 12 |
type i fipv | 12 |
greater than ms | 12 |
been demonstrated to | 12 |
across the globe | 12 |
the study period | 12 |
of intubation or | 12 |
high levels of | 12 |
tmprss and is | 12 |
effectiveness of hcq | 12 |
compared to placebo | 12 |
alone and in | 12 |
than in the | 12 |
clinical studies hydroxychloroquine | 12 |
proven protease inhibitor | 12 |
not show any | 12 |
may lead to | 12 |
viral load reduction | 12 |
and of the | 12 |
de pacientes en | 12 |
el de los | 12 |
of these two | 12 |
with a combination | 12 |
studies have reported | 12 |
with hcq in | 12 |
identified as a | 12 |
with the glycosylation | 12 |
that the anti | 12 |
would like to | 12 |
did not find | 12 |
institutes of health | 12 |
been linked to | 12 |
interferes with the | 12 |
hcq was not | 12 |
hcq in combination | 12 |
hepatitis c virus | 12 |
evidence to support | 11 |
this drug is | 11 |
characteristics and outcomes | 11 |
by the spike | 11 |
the scientific community | 11 |
has been observed | 11 |
dosis de mg | 11 |
higher in the | 11 |
have been conducted | 11 |
expression of crh | 11 |
a subset of | 11 |
use of other | 11 |
final de la | 11 |
no significant effect | 11 |
convalescent plasma therapy | 11 |
and the use | 11 |
effects on the | 11 |
the interpretation of | 11 |
shown in table | 11 |
hepatitis b virus | 11 |
s and s | 11 |
the mean age | 11 |
after symptom onset | 11 |
higher rates of | 11 |
factors for mortality | 11 |
and duration of | 11 |
likely to have | 11 |
efficacy of the | 11 |
disease in china | 11 |
the original data | 11 |
the start of | 11 |
is likely to | 11 |
of action and | 11 |
clinical improvement in | 11 |
glycosylation of the | 11 |
of the sprotein | 11 |
treatment in the | 11 |
role of chloroquine | 11 |
among patients who | 11 |
en la mortalidad | 11 |
of cq on | 11 |
hydroxychloroquine as an | 11 |
mg twice a | 11 |
transfer to the | 11 |
creative commons attribution | 11 |
lead to the | 11 |
of systematic reviews | 11 |
and patients with | 11 |
the cytokine storm | 11 |
sobre el uso | 11 |
hydroxychloroquine and covid | 11 |
crh in the | 11 |
risk of covid | 11 |
que los pacientes | 11 |
before and after | 11 |
in this article | 11 |
hcq was found | 11 |
higher proportion of | 11 |
study found that | 11 |
adult inpatients with | 11 |
lessons from the | 11 |
was reported by | 11 |
in the studies | 11 |
it is difficult | 11 |
daily on day | 11 |
el tiempo de | 11 |
utilizar de forma | 11 |
can lead to | 11 |
of bias in | 11 |
shown that the | 11 |
in a small | 11 |
asai et al | 11 |
on day and | 11 |
the creative commons | 11 |
from malaria to | 11 |
all authors have | 11 |
animal toxicity and | 11 |
prolongation in covid | 11 |
drugs for the | 11 |
there is currently | 11 |
into the antiviral | 11 |
and more than | 11 |
trial no evidence | 11 |
is necessary to | 11 |
defined as a | 11 |
mortality rate of | 11 |
patients with moderate | 11 |
found that hcq | 11 |
case of covid | 11 |
hcq has a | 11 |
mortality rate in | 11 |
and severity of | 11 |
in the same | 11 |
angiotensin converting enzyme | 11 |
of which are | 11 |
in clinical practice | 11 |
the data of | 11 |
de salud y | 11 |
at risk for | 11 |
hcq plus az | 11 |
term treatment with | 11 |
and cq have | 11 |
of clinical efficacy | 11 |
in autoimmune diseases | 11 |
had no significant | 11 |
the study of | 11 |
in supplementary table | 11 |
cq hcq on | 11 |
but not in | 11 |
was not significantly | 11 |
cytokines such as | 11 |
was a significant | 11 |
taking into account | 11 |
in the number | 11 |
the antiviral effect | 11 |
the aim of | 11 |
viral load and | 11 |
the active site | 11 |
and in combination | 11 |
was performed to | 11 |
a code for | 11 |
a protective effect | 11 |
at higher risk | 11 |
and cq in | 11 |
prevention and treatment | 11 |
clinical trial clinical | 11 |
in acute respiratory | 11 |
the institutional review | 11 |
the ability to | 11 |
li et al | 11 |
was not different | 11 |
chloroquine and its | 11 |
efficacy against sars | 11 |
the current pandemic | 11 |
this is an | 11 |
on the corrected | 11 |
en el contexto | 11 |
and chloroquine during | 11 |
symptoms of covid | 11 |
with cq or | 11 |
age and gender | 11 |
be more effective | 11 |
con el fin | 11 |
is difficult to | 11 |
those who received | 11 |
in a cohort | 11 |
chronic treatment with | 11 |
twice a day | 11 |
fold increase in | 11 |
data suggest that | 11 |
association of hcq | 11 |
treatment in patients | 11 |
to hcq and | 11 |
positive effect of | 11 |
activity of chloroquine | 11 |
risk of tdp | 11 |
viral entry and | 11 |
the same time | 11 |
of patients from | 11 |
model was used | 11 |
fuera de la | 11 |
at the beginning | 11 |
doses of cq | 11 |
analysis revealed that | 11 |
a study using | 11 |
use for the | 11 |
chloroquine for covid | 11 |
of cytochrome p | 11 |
novel coronavirus from | 11 |
in vitro hydroxychloroquine | 11 |
clinical trial of | 11 |
the purpose of | 11 |
we do not | 11 |
because of its | 11 |
initiation of hcq | 11 |
excluded from the | 11 |
with a code | 11 |
el fin de | 11 |
hcq to treat | 11 |
a day for | 11 |
with pneumonia in | 11 |
in the intensive | 11 |
of viral particles | 11 |
once daily for | 11 |
of t cells | 11 |
resolution of symptoms | 11 |
toxicity and pharmacokinetics | 11 |
of mg kg | 11 |
and its derivative | 11 |
related to covid | 11 |
sample size of | 11 |
prevention and control | 11 |
and congestive heart | 11 |
using routinely collected | 11 |
surviving sepsis campaign | 11 |
lower in the | 11 |
cells of the | 11 |
in a large | 11 |
the patients in | 11 |
suggests that the | 11 |
side effects and | 11 |
of retinal toxicity | 11 |
the first trimester | 11 |
de la vida | 11 |
studies are needed | 11 |
risk of developing | 11 |
obstructive pulmonary disease | 11 |
trial clinical and | 11 |
shown to inhibit | 11 |
risk of hcq | 11 |
ministry of health | 11 |
in any of | 11 |
viral entry into | 11 |
especially in the | 11 |
significant differences between | 11 |
routinely collected data | 11 |
was conducted in | 11 |
no difference in | 11 |
based on these | 11 |
more than one | 11 |
the ace receptor | 11 |
mortality associated with | 11 |
length of hospital | 11 |
stages of the | 11 |
a median of | 11 |
with qt prolongation | 11 |
prior to the | 11 |
and inhibition of | 11 |
been proposed as | 11 |
and hydroxychloroquine are | 11 |
a significant reduction | 11 |
side effect of | 11 |
or treatment of | 11 |
personal protective equipment | 10 |
and use of | 10 |
been suggested as | 10 |
with hcq monotherapy | 10 |
appear to be | 10 |
the objective of | 10 |
thought to be | 10 |
los niveles de | 10 |
these drugs for | 10 |
higher than that | 10 |
in a dose | 10 |
a cohort study | 10 |
patients with ra | 10 |
data to emulate | 10 |
authors declare that | 10 |
as it is | 10 |
drugs for covid | 10 |
compared to control | 10 |
herpes simplex virus | 10 |
en los que | 10 |
suggest that hcq | 10 |
hcq should be | 10 |
in the experimental | 10 |
the initiation of | 10 |
used in combination | 10 |
assessment of the | 10 |
use in the | 10 |
college of cardiology | 10 |
with a median | 10 |
label nonrandomized clinical | 10 |
qt prolongation in | 10 |
and did not | 10 |
in the intervention | 10 |
decreased mortality in | 10 |
stable binding of | 10 |
and prophylaxis of | 10 |
in view of | 10 |
la posibilidad de | 10 |
lee et al | 10 |
adverse events in | 10 |
differences between the | 10 |
hcq and the | 10 |
known to be | 10 |
suggested that the | 10 |
of patients receiving | 10 |
el uso del | 10 |
hcq may also | 10 |
are known to | 10 |
for qtc prolongation | 10 |
inhibits the replication | 10 |
were used for | 10 |
no conflicts of | 10 |
se recomienda el | 10 |
the dose of | 10 |
serie de casos | 10 |
un estudio retrospectivo | 10 |
the mortality rate | 10 |
in vitro efficacy | 10 |
to account for | 10 |
use of this | 10 |
the studies included | 10 |
between the hcq | 10 |
in this context | 10 |
dose of cq | 10 |
for more than | 10 |
related to hcq | 10 |
for age and | 10 |
health commission of | 10 |
mortality of adult | 10 |
more potent than | 10 |
of this article | 10 |
a group of | 10 |
de estos pacientes | 10 |
with a high | 10 |
higher risk for | 10 |
both hcq and | 10 |
severity of illness | 10 |
statement from the | 10 |
la unidad de | 10 |
disease in the | 10 |
diagnosis of covid | 10 |
of human immunodeficiency | 10 |
emulate a target | 10 |
con el uso | 10 |
of this review | 10 |
that of hcq | 10 |
size of the | 10 |
of the human | 10 |
of mg day | 10 |
of corticosteroids in | 10 |
proteolytic processing of | 10 |
that it is | 10 |
trials for the | 10 |
studies showed that | 10 |
states food and | 10 |
days in the | 10 |
para el personal | 10 |
de la mortalidad | 10 |
pacientes que recibieron | 10 |
of the potential | 10 |
cyp a and | 10 |
inflammatory cytokines and | 10 |
mg three times | 10 |
and in vitro | 10 |
a key role | 10 |
study was not | 10 |
use associated with | 10 |
to emulate a | 10 |
clinical trials with | 10 |
inflammatory rheumatic diseases | 10 |
the endosomal ph | 10 |
of chloroquine phosphate | 10 |
por lo que | 10 |
hcq plus azithromycin | 10 |
on in vitro | 10 |
higher probability of | 10 |
the onset of | 10 |
and b cells | 10 |
collected data to | 10 |
decrease in the | 10 |
with human immunodeficiency | 10 |
by increasing the | 10 |
that could be | 10 |
the reference group | 10 |
en cuenta la | 10 |
prolonged viral shedding | 10 |
evidence of clinical | 10 |
are reported in | 10 |
by the fact | 10 |
yet to be | 10 |
en el momento | 10 |
treatment of systemic | 10 |
type ii fipv | 10 |
inpatients with covid | 10 |
an overview of | 10 |
whether or not | 10 |
and acute respiratory | 10 |
with a significant | 10 |
mortality in hospitalized | 10 |
the inflammatory response | 10 |
on viral load | 10 |
el manejo del | 10 |
such as rheumatoid | 10 |
when compared with | 10 |
of our study | 10 |
the progression of | 10 |
of cardiovascular death | 10 |
the drug is | 10 |
efficacy against covid | 10 |
lopinavir ritonavir and | 10 |
los trabajadores de | 10 |
was assessed using | 10 |
significant increase in | 10 |
united states food | 10 |
options for covid | 10 |
in contrast to | 10 |
virus replication in | 10 |
se debe considerar | 10 |
we found no | 10 |
than those in | 10 |
for severe covid | 10 |
con sospecha de | 10 |
pointes in patients | 10 |
been used as | 10 |
the metabolism of | 10 |
cq hcq could | 10 |
se recomienda considerar | 10 |
of tocilizumab in | 10 |
under a perpetuity | 10 |
are likely to | 10 |
of ebola virus | 10 |
did not reduce | 10 |
as rheumatoid arthritis | 10 |
they have no | 10 |
which is the | 10 |
el consentimiento informado | 10 |
on the clinical | 10 |
hcq compared to | 10 |
is not known | 10 |
mhc class ii | 10 |
impact on the | 10 |
cumulative dose of | 10 |
chronic kidney disease | 10 |
are summarized in | 10 |
combined with azithromycin | 10 |
due to hydroxychloroquine | 10 |
could lead to | 10 |
of both cq | 10 |
an antimalarial drug | 10 |
it was not | 10 |
exposure to the | 10 |
bioavailability of hydroxychloroquine | 10 |
the stable binding | 10 |
trial efficacy of | 10 |
shown to have | 10 |
higher in patients | 10 |
an ec of | 10 |
early phase of | 10 |
are currently being | 10 |
adverse event reporting | 10 |
there are several | 10 |
risk of hospitalization | 10 |
is due to | 10 |
as prophylaxis for | 10 |
in patients in | 10 |
centers for disease | 10 |
study conducted by | 10 |
contributed to the | 10 |
pacientes hospitalizados con | 10 |
in the analysis | 10 |
of hydroxychloroquine tablets | 10 |
study using routinely | 10 |
risk of intubation | 10 |
pacientes con enfermedad | 10 |
patients who died | 10 |
a study of | 10 |
of a novel | 10 |
inicio de la | 10 |
of hydroxychloroquine treatment | 10 |
of hcq az | 10 |
the generation of | 10 |
qt prolonging medications | 10 |
patients with autoimmune | 10 |
and sudden death | 10 |
has been a | 10 |
cohort of patients | 10 |
observed in patients | 10 |
nonrandomized clinical trial | 10 |
the study population | 10 |
can be seen | 10 |
q fever endocarditis | 10 |
were transferred to | 10 |
el punto de | 10 |
in adult patients | 10 |
a target trial | 10 |
key role in | 10 |
not yet been | 10 |
we used the | 10 |
heart rhythm society | 10 |
of rheumatic diseases | 10 |
for mortality of | 10 |
and heart failure | 10 |
the small sample | 10 |
se recomienda utilizar | 10 |
upper respiratory tract | 10 |
as evidenced by | 10 |
was added to | 10 |
characteristics of hospitalized | 10 |
the in vivo | 10 |
new york city | 10 |
the lpv r | 10 |
hydroxychloroquine as a | 10 |
with cq hcq | 10 |
patients suspected of | 10 |
evidence of a | 10 |
found that cq | 10 |
of the combination | 10 |
effective in reducing | 10 |
in this meta | 10 |
the potential to | 10 |
the experimental group | 10 |
of adult inpatients | 10 |
and lopinavir ritonavir | 10 |
evaluation of the | 10 |
findings suggest that | 10 |
and antiviral activities | 10 |
se puede considerar | 10 |
a single center | 10 |
did not include | 10 |
course and risk | 10 |
a period of | 10 |
in conjunction with | 10 |
pcr para sars | 10 |
that cq could | 9 |
r and hcq | 9 |
and cardiac arrest | 9 |
plasma levels of | 9 |
of these agents | 9 |
remdesivir for patients | 9 |
critically ill adults | 9 |
of total aes | 9 |
viral replication in | 9 |
en todos los | 9 |
we aimed to | 9 |
in preventing infection | 9 |
patients with confirmed | 9 |
pneumonia in china | 9 |
concentrations in the | 9 |
web of science | 9 |
in the majority | 9 |
no statistically significant | 9 |
incidence of adverse | 9 |
therapy for covid | 9 |
syndrome coronavirus infection | 9 |
when combined with | 9 |
the form of | 9 |
the type of | 9 |
from in vitro | 9 |
coronavirus replication in | 9 |
levels in patients | 9 |
de los casos | 9 |
hcq blood levels | 9 |
the potential for | 9 |
profesionales de la | 9 |
cox proportional hazards | 9 |
to the lack | 9 |
in the blood | 9 |
and side effects | 9 |
within the first | 9 |
prevention or treatment | 9 |
to be considered | 9 |
en pacientes que | 9 |
the result of | 9 |
the intervention arm | 9 |
more than ms | 9 |
the relative risk | 9 |
on days and | 9 |
use of convalescent | 9 |
with autoimmune diseases | 9 |
activity of the | 9 |
la pandemia covid | 9 |
macrophage activation syndrome | 9 |
reported that hcq | 9 |
a statistically significant | 9 |
la incidencia de | 9 |
the survey was | 9 |
reduction of covid | 9 |
up to of | 9 |
associated with acute | 9 |
of remdesivir and | 9 |
a systematic search | 9 |
median age of | 9 |
did not result | 9 |
during the study | 9 |
it is still | 9 |
in these studies | 9 |
associated with sars | 9 |
qtc prolongation was | 9 |
for the diagnosis | 9 |
compared with a | 9 |
hospitalised patients with | 9 |
syndrome coronavirus by | 9 |
outside of the | 9 |
were performed in | 9 |
and torsades de | 9 |
a h n | 9 |
a descriptive study | 9 |
hcq treatment in | 9 |
in response to | 9 |
for the next | 9 |
hydroxychloroquine tablets in | 9 |
in mice and | 9 |
with oxygen requirement | 9 |
clinical benefit of | 9 |
lupus erythematosus hydroxychloroquine | 9 |
drugs to treat | 9 |
hydroxychloroquine use associated | 9 |
the most commonly | 9 |
desde el inicio | 9 |
and have a | 9 |
preliminary results from | 9 |
rbd of sars | 9 |
of cyclic gmp | 9 |
drug for the | 9 |
ec values for | 9 |
in severe cases | 9 |
metabolism of chloroquine | 9 |
for this study | 9 |
in the low | 9 |
analysis of data | 9 |
concentrations of cq | 9 |
mortality in the | 9 |
for acute respiratory | 9 |
the clinical efficacy | 9 |
required for the | 9 |
into two groups | 9 |
frequency of lqt | 9 |
not in the | 9 |
in the time | 9 |
and lpv r | 9 |
and hcq use | 9 |
observational cohort study | 9 |
admission to the | 9 |
in patients at | 9 |
a significant increase | 9 |
clinical trial efficacy | 9 |
use for covid | 9 |
the mice were | 9 |
and clinical characteristics | 9 |
replication in cell | 9 |
protective effect of | 9 |
maintenance dose of | 9 |
cov and mers | 9 |
the middle east | 9 |
attributed to the | 9 |
infection with oxygen | 9 |
as a binary | 9 |
of disease severity | 9 |
to describe the | 9 |
and qtc prolongation | 9 |
en tiempos de | 9 |
has shown that | 9 |
moderate to severe | 9 |
in the pbs | 9 |
and synthesis of | 9 |
course of disease | 9 |
hcq and azm | 9 |
el momento de | 9 |
mrna expression of | 9 |
major congenital malformations | 9 |
early in the | 9 |
de pointes and | 9 |
durante la pandemia | 9 |
there is still | 9 |
were associated with | 9 |
to an increased | 9 |
is essential for | 9 |
in healthcare settings | 9 |
of this combination | 9 |
due to a | 9 |
these drugs strongly | 9 |
mg on day | 9 |
potential inhibitors of | 9 |
years of age | 9 |
el cual se | 9 |
adverse events were | 9 |
to severe acute | 9 |
treatment in covid | 9 |
at increased risk | 9 |
evaluate the efficacy | 9 |
properties of hcq | 9 |
positive for sars | 9 |
led to a | 9 |
discontinuation of hcq | 9 |
of the total | 9 |
los efectos adversos | 9 |
in saudi arabia | 9 |
for critically ill | 9 |
by using the | 9 |
to increase the | 9 |
and hcq as | 9 |
lack of randomisation | 9 |
observational study conducted | 9 |
that hcq can | 9 |
observational studies and | 9 |
influenza a h | 9 |
lopinavir and ritonavir | 9 |
that the combination | 9 |
toma de decisiones | 9 |
action of hcq | 9 |
the growth of | 9 |
indicated that the | 9 |
of the ace | 9 |
that cq is | 9 |
severe cases of | 9 |
studies with a | 9 |
of either cq | 9 |
cleavage of the | 9 |
the american college | 9 |
inhibited by hcq | 9 |
the assessment of | 9 |
controlled clinical trial | 9 |
clinical trials of | 9 |
green monkey kidney | 9 |
the host cells | 9 |
una estrategia de | 9 |
used in covid | 9 |
with a special | 9 |
assess the efficacy | 9 |
mild to severe | 9 |
coronavirus by chloroquine | 9 |
examine the effect | 9 |
outcomes of critically | 9 |
not been reported | 9 |
of in vitro | 9 |
trials are currently | 9 |
risk of malformations | 9 |
prolongation and refractory | 9 |
hcq with azithromycin | 9 |
from the coronavirus | 9 |
clinical studies have | 9 |
la capacidad de | 9 |
effective against sars | 9 |
to use hcq | 9 |
to patients with | 9 |
approved for the | 9 |
viral rna synthesis | 9 |
from a single | 9 |
of drug treatment | 9 |
may be due | 9 |
in the in | 9 |
seen in the | 9 |
en cuanto a | 9 |
acute kidney injury | 9 |
to the virus | 9 |
shown that hcq | 9 |
is related to | 9 |
ivermectin inhibits the | 9 |
hydroxychloroquine in preventing | 9 |
cases and controls | 9 |
which may be | 9 |
is an urgent | 9 |
been identified as | 9 |
high doses of | 9 |
was determined to | 9 |
hcq appears to | 9 |
be inhibited by | 9 |
the difference in | 9 |
innate and adaptive | 9 |
it is unclear | 9 |
patients who have | 9 |
que no se | 9 |
to the small | 9 |
in hospitalised patients | 9 |
respiratory failure in | 9 |
around the world | 9 |
hydroxychloroquine is associated | 9 |
in observational studies | 9 |
for inhibition of | 9 |
is used in | 9 |
for novel coronavirus | 9 |
these drugs have | 9 |
recommendation to examine | 9 |
potential risk of | 9 |
tener en cuenta | 9 |
disease caused by | 9 |
and combination in | 9 |
of viral load | 9 |
transporting polypeptide a | 9 |
with hcq with | 9 |
boulware et al | 9 |
intensive care units | 9 |
hcq mg twice | 9 |
virological and clinical | 9 |
line with the | 9 |
of intensive care | 9 |
the patients were | 9 |
in reducing the | 9 |
expression levels of | 9 |
summarized in table | 9 |
patients suffering from | 9 |
luego de la | 9 |
treatment of rheumatic | 9 |
of which were | 9 |
total number of | 9 |
for statistical computing | 9 |
time of writing | 9 |
of data from | 9 |
dados de alta | 9 |
after a single | 9 |
and tumor necrosis | 9 |
and prevention of | 9 |
a broad spectrum | 9 |
are included in | 9 |
structure of the | 9 |
phase of the | 9 |
it is worth | 9 |
hcq is not | 9 |
the critically ill | 9 |
combination of these | 9 |
spike glycoprotein and | 9 |
of viral replication | 9 |
the safety profile | 9 |
studies have also | 9 |
with mg kg | 9 |
exposed to hcq | 9 |
associated with disease | 9 |
were reported in | 9 |
wide range of | 9 |
viral clearance and | 9 |
the administration of | 9 |
management of patients | 9 |
inhibition of severe | 9 |
used to predict | 9 |
caused by severe | 9 |
therapy in the | 9 |
the early phase | 9 |
host cells through | 9 |
of transfer to | 9 |
in t cells | 9 |
of the results | 9 |
en el de | 9 |
the high dose | 9 |
management of the | 9 |
of the lung | 9 |
was used in | 9 |
use of a | 9 |
plasma and lung | 9 |
the immune response | 9 |
chronic hydroxychloroquine use | 9 |
should be used | 9 |
in the form | 9 |
human subject research | 9 |
iib clinical trial | 9 |
the propensity score | 9 |
baseline qtc was | 9 |
in plasma and | 9 |
infection in a | 9 |
severe qtc prolongation | 9 |
manejo de pacientes | 9 |
and cq can | 9 |
a recommendation to | 9 |
en el marco | 9 |
la calidad de | 9 |
risk of retinopathy | 9 |
in the past | 9 |
a wide range | 9 |
that the effect | 9 |
chloroquine and covid | 9 |
we need to | 9 |
matched cohort study | 9 |
el personal de | 9 |
of acute respiratory | 9 |
and refractory ventricular | 9 |
with an ec | 9 |
body mass index | 9 |
the prevention and | 9 |
all of the | 9 |
their use in | 9 |
strength of the | 9 |
an et al | 9 |
del uso de | 9 |
randomized controlled studies | 9 |
safety of the | 9 |
large volume of | 9 |
to support the | 9 |
with severe respiratory | 9 |
in an in | 9 |
combination in patients | 9 |
virus replication by | 9 |
been demonstrated that | 9 |
a difference in | 9 |
outcomes such as | 9 |
be responsible for | 9 |
which leads to | 9 |
the process of | 9 |
such as il | 9 |