trigram

This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

trigram frequency
in patients with619
the treatment of442
patients with covid441
treatment of covid377
cq and hcq356
severe acute respiratory289
for the treatment281
acute respiratory syndrome265
the use of263
respiratory syndrome coronavirus228
chloroquine and hydroxychloroquine196
display the preprint191
who has granted191
license to display191
medrxiv a license191
the preprint in191
to display the191
has granted medrxiv191
hydroxychloroquine and azithromycin191
a license to191
granted medrxiv a191
in the treatment189
of hydroxychloroquine in184
the copyright holder184
the risk of183
copyright holder for179
holder for this179
systemic lupus erythematosus176
the author funder170
is the author170
as well as159
this version posted157
of patients with155
preprint in perpetuity154
with or without153
a systematic review148
patients treated with146
is made available145
of cq and144
for this preprint143
it is made141
made available under141
available under a141
international license it139
license it is139
en pacientes con138
treated with hcq133
of hydroxychloroquine and130
randomized clinical trial128
hospitalized patients with120
in combination with120
use of hcq118
patients with severe114
pacientes con covid113
of chloroquine and112
under a is111
a is the111
hcq and cq109
the effect of109
of severe acute108
this preprint this108
preprint this version108
due to the108
which was not103
hydroxychloroquine in patients102
of hcq in99
of hcq and98
in hospitalized patients98
with severe covid96
efficacy and safety95
of cq hcq95
of action of93
certified by peer91
by peer review91
not certified by91
was not certified91
of these drugs90
el uso de89
as a treatment89
intensive care unit88
systematic review and87
cq or hcq85
and safety of84
in this study83
effect of hcq83
for treatment of82
respiratory distress syndrome81
de los pacientes80
was associated with78
acute respiratory distress78
in order to77
the control group77
in the hcq76
critically ill patients76
a total of75
in treatment of75
followed by mg75
is associated with75
treatment of severe75
one of the75
the combination of74
p r e74
o o f73
a l p73
j o u73
u r n73
it has been73
r n a73
l p r73
p r o73
n a l73
o u r73
use of hydroxychloroquine73
r o o73
associated with a72
treated with hydroxychloroquine72
a treatment of72
the efficacy of72
mechanism of action70
effects of chloroquine70
based on the70
mg twice daily69
and azithromycin as69
review and meta69
dose of mg69
been shown to68
with coronavirus disease68
azithromycin as a67
and azithromycin in67
efficacy of hydroxychloroquine66
results of an66
a combination of66
in vitro antiviral66
for patients with66
patients in the65
hydroxychloroquine and chloroquine65
included in the64
this article is64
increased risk of64
of the patients64
of an open63
all rights reserved63
vitro antiviral activity63
los pacientes con63
or in combination63
con sospecha o63
qt interval prolongation63
of hydroxychloroquine for63
the qt interval62
a randomized clinical62
hydroxychloroquine for the62
alone or in60
there was no60
of coronavirus disease60
of the disease60
east respiratory syndrome59
results of a59
to evaluate the58
the time of58
middle east respiratory58
study of hydroxychloroquine58
torsade de pointes57
treatment with hydroxychloroquine57
the management of57
patients with coronavirus56
in vitro and56
the efficacy and55
mild to moderate55
ill patients with55
review of the55
antiviral activity and55
the number of55
world health organization55
mechanisms of action54
the context of54
the role of54
the effects of54
in the control54
dosing design of53
of optimized dosing53
design of hydroxychloroquine53
with systemic lupus53
projection of optimized53
the hcq group53
en los pacientes53
of the study53
and projection of53
optimized dosing design53
standard of care53
activity and projection53
hcq with or52
for coronavirus disease52
version posted june52
en el paciente52
combination of hydroxychloroquine52
with hydroxychloroquine and52
hcq in covid51
randomized controlled trial51
treatment with hcq51
efficacy of hcq51
treatment of patients50
and hydroxychloroquine in50
has been shown50
use of cq49
at the time49
infection in vitro49
protected by copyright49
de pacientes con49
is protected by49
the presence of49
article is protected49
the results of49
mortality in patients49
in systemic lupus49
or without azithromycin49
with rheumatoid arthritis49
hcq has been48
to assess the48
patients with sars48
of novel coronavirus48
gautret et al48
in the context48
and hcq in48
according to the47
in addition to47
combination with azithromycin47
compared to the47
in inhibiting sars47
antiviral activity of46
the absence of46
patients infected with46
was used to46
antiviral effects of46
no significant difference45
and hcq are45
systematic review of45
found to be45
the united states45
used in the45
in terms of45
of qtc prolongation44
of a randomized44
effects of hcq44
observational study of44
hydroxychloroquine in hospitalized44
no evidence of44
risk of bias44
were treated with44
risk factors for43
has been reported43
the fact that43
of hcq on43
the lack of43
de la enfermedad43
daily for days42
safety and efficacy42
treatment for covid42
el riesgo de42
on the other42
patients with rheumatoid42
vitro and in41
effective in inhibiting41
a less toxic41
patients hospitalized with41
twice daily for41
effectively inhibit the40
higher risk of40
the antiviral effects40
hospitalized with covid40
the recently emerged40
derivative of chloroquine40
qt prolongation and40
of the drugs40
in new york40
emerged novel coronavirus40
there is no40
torsades de pointes40
vero e cells40
retrospective cohort study40
remdesivir and chloroquine40
the host cell40
in clinical studies40
inhibit the recently39
dose of hcq39
the other hand39
associated pneumonia in39
and chloroquine effectively39
less toxic derivative39
clinical characteristics of39
toxic derivative of39
chloroquine effectively inhibit39
is effective in39
effect of hydroxychloroquine39
recently emerged novel39
of the drug39
in critically ill38
as compared to38
used to treat38
of the virus38
of treatment with38
has shown apparent37
and in vivo37
patients with systemic37
use of chloroquine37
combination of hcq37
apparent efficacy in37
of critically ill37
the development of37
the two groups37
small sample size37
shown apparent efficacy37
pneumonia in clinical37
efficacy in treatment37
se recomienda no37
food and drug37
chloroquine phosphate has36
en el grupo36
there is a36
for this this36
preprint the copyright36
this this version36
the novel coronavirus36
both cq and36
between the two36
the present study36
and drug administration36
systematic reviews and36
and treatment of36
was found to36
in patients treated36
the need for36
pharmacokinetics of hydroxychloroquine36
phosphate has shown36
clinical efficacy of36
effect of chloroquine36
patients with mild36
in the study36
version posted november36
of chloroquine on36
hospitalized with severe35
hcq and azithromycin35
qt interval in35
with severe acute35
has also been35
hydroxychloroquine in the35
effects of cq35
of hospitalized patients35
and efficacy of34
de la salud34
in a patient34
a patient with34
hcq and rfifn34
of qt interval34
hydroxychloroquine with or34
in vitro studies34
tumor necrosis factor34
of clinical trials34
used for the34
a retrospective cohort34
a dose of34
significant difference in33
the inhibition of33
effect of a33
version posted may33
supplementary table s33
type i ifn33
time to clinical33
than that of33
of this study33
the incidence of33
with at least33
not associated with33
the mechanism of33
in patients hospitalized33
infected with sars32
any of the32
for cq and32
the replication of32
shown to be32
risk of qt32
of the viral32
novel coronavirus pneumonia32
el manejo de32
most of the32
the case of32
treatment of sars32
an increase in32
of the included32
side effects of32
hcq in the32
it should be32
patients receiving hcq31
the expression of31
human immunodeficiency virus31
role in the31
with novel coronavirus31
pacientes con sospecha31
of hcq is31
during the covid31
the most common31
and hcq have31
the world health31
the effectiveness of31
the intensive care31
interval in patients31
of the literature31
action of hydroxychloroquine31
the production of30
number of patients30
la presencia de30
in rheumatoid arthritis30
potent inhibitor of30
azithromycin in covid30
an increased risk30
with the combination30
has not been30
the viral load30
of cq or30
yao et al30
se recomienda la30
on the efficacy30
the first day30
the rate of30
with hcq and30
mg per day30
in the early30
involved in the30
a randomized trial30
have been reported30
the activation of30
was defined as30
hospital mortality in30
use of these30
the safety of29
outcomes of hydroxychloroquine29
rheumatoid arthritis and29
increase the risk29
at least a29
of hcq was29
clinical trials are29
at a dose29
of a combination29
activity against sars29
the majority of29
in the absence29
randomized controlled trials29
to treat covid29
there are no29
have shown that29
in clinical trials29
mg daily for28
randomized clinical trials28
the severe acute28
or clinical benefit28
with the use28
de cuidados intensivos28
randomised controlled trial28
due to its28
with use of28
prophylaxis for covid28
management of covid28
least a six28
of the studies28
patients with at28
patients who received28
well as the28
los pacientes que28
there was a28
to clinical improvement28
day follow up28
in severe covid28
in the lung28
association of treatment28
reviews and meta28
in the united28
the duration of27
of the sars27
the coronavirus disease27
inhibitor of sars27
the immune system27
safety of hcq27
is important to27
clearance or clinical27
of sars coronavirus27
increase in the27
series of patients27
the impact of27
of hydroxychloroquine with27
a higher risk27
been reported to27
evidence for the27
emergency use authorization27
conflict of interest27
of hcq with27
a pilot study27
related to the27
effect of cq27
as shown in27
as adjunctive therapy27
microbiological effect of26
the course of26
with hydroxychloroquine or26
of chloroquine against26
chloroquine or hydroxychloroquine26
this study was26
drugs in the26
viral shedding duration26
there were no26
who received hcq26
hydroxychloroquine or azithromycin26
benefit with the26
in treating covid26
or azithromycin with26
have also been26
a novel coronavirus26
a potent inhibitor26
to the control26
effects of hydroxychloroquine26
version posted july26
need to be26
it is important26
and microbiological effect26
to have a26
compared to those26
mode of action26
studies have shown26
azithromycin in patients26
in vitro activity26
evidence of rapid26
associated with the26
clinical and microbiological26
some of the26
patients who were26
of the treatment26
controlled clinical trials25
wang et al25
in animal models25
new york state25
the qtc interval25
per day for25
chloroquine is a25
in the management25
in light of25
hcq in patients25
a number of25
of hydroxychloroquine on25
the safety and25
be associated with25
these drugs in25
as a result25
associated with use25
clinical benefit with25
treated with cq25
was no significant25
qtc prolongation in25
antiviral clearance or25
have been shown25
in the case25
chloroquine for the25
shown in figure25
showed that the25
a case series25
azithromycin with in25
were included in25
the antiviral activity25
of rapid antiviral25
rapid antiviral clearance25
in a recent25
the possibility of24
a pilot observational24
a review of24
patients with a24
of the data24
case series of24
and hydroxychloroquine as24
an old drug24
has been used24
trial of hydroxychloroquine24
the release of24
moderate coronavirus disease24
sars coronavirus infection24
pilot observational study24
teniendo en cuenta24
congestive heart failure24
the end of24
the ph of24
on the use24
was not associated24
hydroxychloroquine or chloroquine24
analysis of the24
a randomized controlled24
to be effective24
the original paper24
cases of covid24
who did not23
of hydroxychloroquine as23
associated with an23
implications for rheumatology23
the study was23
serious adverse events23
and rheumatoid arthritis23
the primary outcome23
with mild to23
prolongation associated with23
cq hcq in23
been associated with23
due to covid23
treatment of malaria23
it is also23
hcq alone or23
for the management23
coronavirus infection and23
hcq and az23
of hcq for23
recomienda no utilizar23
of hcq to23
should not be23
para el manejo23
activation of the23
not included in23
paciente con sospecha23
infection treated with23
in vitro in23
during the first23
novel coronavirus in23
between hcq and23
risk of adverse23
did not show23
cov and sars23
activity of cq23
of convalescent plasma23
acute lung injury23
pilot study of23
of the hcq23
of patients infected22
was not peer22
institutional review board22
study of patients22
in this review22
patients testing positive22
hcq have been22
cq has been22
was observed in22
the severity of22
inhibition of the22
hydroxychloroquine in treatment22
in the covid22
we did not22
the included studies22
in patients receiving22
of adverse events22
el grupo de22
hospitalized for covid22
effects of the22
en caso de22
use in covid22
associated with hcq22
is a potent22
infection and spread22
mg kg day22
therapy for patients22
of chloroquine in22
the in vitro22
difference in the22
data from the22
as a potential22
appears to be22
se recomienda que22
in the present21
of the covid21
of this drug21
qt interval and21
to be a21
a recent study21
a reduction in21
el paciente con21
none of the21
corrected qt interval21
are needed to21
factors associated with21
action of cq21
that of the21
mortality in covid21
of the two21
testing positive for21
risk of death21
patients with acute21
and outcomes of21
of the qt21
of systemic lupus21
of qt prolongation21
ongoing clinical trials21
due to their21
chloroquine and hcq21
la necesidad de21
risk of mortality21
and systemic lupus21
a clinical trial21
day for days21
of the pandemic21
a retrospective analysis21
resulted in a21
in hospitalized covid21
to reduce the21
of severe covid21
of observational studies21
to moderate coronavirus21
hydroxychloroquine in covid21
diseases such as21
that there was21
connective tissue diseases21
and in the21
of chloroquine diphosphate21
and mortality in20
were found to20
hcq for the20
interval prolongation associated20
a narrative review20
the authors declare20
no significant differences20
hcq or cq20
showed that hcq20
of rheumatoid arthritis20
among hospitalized patients20
hydroxychloroquine usage in20
in adults hospitalized20
of the first20
a author funder20
course of covid20
results showed that20
doses of hcq20
was performed using20
has been demonstrated20
usage in united20
is based on20
in the first20
united states veterans20
viral load in20
the outcome of20
to our knowledge20
patients with mainly20
hcq was associated20
in united states20
was used for20
associated with increased20
seems to be20
patients hospitalized for20
veterans hospitalized with20
mainly mild to20
type i interferon20
states veterans hospitalized20
adverse effects of20
el tratamiento de20
significant effect of20
early treatment of20
it is not20
drugs have been20
be due to20
of antimalarial drugs20
pneumonia in wuhan20
el inicio de20
morbidity and mortality20
with respect to20
on patients with20
under a author20
of lopinavir ritonavir20
approved by the20
of hydroxychloroquine usage20
with hydroxychloroquine azithromycin20
an observational study20
with mainly mild20
of chloroquine for20
activity of hcq20
of torsade de19
could not be19
del paciente con19
en un estudio19
prophylactic and therapeutic19
that the use19
for the prevention19
use authorization for19
diphosphate as adjunctive19
chloroquine on viral19
administration of hcq19
sudden cardiac death19
can be used19
of hydroxychloroquine sulfate19
needs to be19
combination with other19
adjunctive therapy for19
concomitant azithromycin among19
should be noted19
feline infectious peritonitis19
for mechanical ventilation19
are associated with19
and azithromycin on19
of type i19
as a prophylactic19
of patients were19
mg bid for19
de la uci19
or hcq with19
hospitalized patients testing19
pacientes con sdra19
such as the19
hcq use in19
caused by the19
the treatment group19
old drug against19
is one of19
azithromycin among hospitalized19
prolongation of the19
significant differences in19
chloroquine diphosphate as19
to inhibit the19
in coronavirus disease19
therapy in covid19
on viral infections19
each of the19
of cq in19
or without concomitant19
with azithromycin in19
cardiac side effects19
without concomitant azithromycin19
in the liver19
for patients hospitalized19
lupus erythematosus and19
in accordance with19
also been reported19
vitro in vitro19
compared with the19
were observed in19
the findings of19
the availability of19
novel coronavirus disease19
de pointes in19
por lo tanto19
positive for coronavirus19
no utilizar de18
glycosylation of ace18
low doses of18
hcq did not18
paciente con covid18
lower than that18
the prevention of18
and qt prolongation18
in the high18
for systematic reviews18
as postexposure prophylaxis18
on the first18
no conflict of18
t cells and18
coronary artery disease18
be used to18
the comparison group18
doses of chloroquine18
with a macrolide18
en el tratamiento18
reported to be18
the occurrence of18
of lpv r18
of these studies18
a trial of18
qtc prolongation and18
because of the18
by mg twice18
by hcq and18
the viral shedding18
used as a18
to be more18
conflicts of interest18
controlled trial of18
to moderate covid18
a cohort of18
randomized trial of18
vitro activity against18
acute respiratory failure18
to investigate the18
days of treatment18
risk of qtc18
of the most18
were used to18
of high vs18
in vitro inhibition18
cq and or18
included in this18
the binding energy18
reduction in the18
for disease control18
responsible for the18
effect of high18
volume of distribution18
when compared to18
with rheumatic diseases18
se recomienda en18
were performed using18
ischemic heart disease18
from patients with18
polymerase chain reaction18
are shown in18
with hcq or18
preferred reporting items18
cytokine release syndrome18
in a study18
del estado de18
a retrospective study18
is mediated by18
in intensive care18
efficacy of cq18
clinical features of18
a variety of18
nature of the18
reporting items for18
the quality of18
in our study18
in vero e18
and or hcq18
it is possible18
large number of18
analyses were performed18
the control arm18
de forma rutinaria18
of hcq as18
with acute respiratory18
the association between18
clinical trials have18
de alto flujo18
the treatment and18
obtained from the17
to note that17
significant difference between17
safety of hydroxychloroquine17
the association of17
vitro inhibition of17
hydroxychloroquine as postexposure17
cardiac complications attributed17
effect of the17
significant reduction in17
inicio de los17
the time to17
the level of17
common coronavirus disease17
de acuerdo con17
the s protein17
its ability to17
to determine the17
of hcq use17
has been proposed17
mediated by the17
several clinical trials17
in the hippocampus17
the need to17
study showed that17
reported in the17
trial of lopinavir17
for the use17
clinical course and17
savarino et al17
the hcq arm17
a series of17
with common coronavirus17
in the current17
of the immune17
these drugs are17
patients with rheumatic17
e qt ratio17
in patients who17
de la terapia17
in vitro data17
insights into the17
patients with novel17
patients with common17
total of patients17
associated with lower17
to that of17
be noted that17
extracorporeal membrane oxygenation17
with lopinavir ritonavir17
long qt syndrome17
of patients in17
of hcq or17
a significant effect17
and risk factors17
in the risk17
the addition of17
a result of17
results of the17
with cq and17
complications attributed to17
cq hcq may17
of viral rna17
we found that17
proportion of patients17
lower respiratory tract17
have not been17
be used in17
analysis was performed17
m a n17
an intensive care17
interval prolongation in17
been reported in17
such as systemic17
of adverse effects17
adults hospitalized with17
of mg twice17
hydroxychloroquine for covid17
inhibition of human17
compassionate use of17
hcq for covid17
or without a17
systematic review on16
there is an16
in the meta16
considered to be16
that in the16
geleris et al16
have been proposed16
treatments for coronavirus16
been reported that16
si el paciente16
prophylaxis of covid16
vincent et al16
is known to16
in a case16
treatment of novel16
have been used16
the corrected qt16
of hcq treatment16
it is a16
of the original16
showed that cq16
did not receive16
high vs low16
viral replication and16
y cols en16
vs low doses16
on the basis16
a case report16
with and without16
u s c16
which is a16
in of patients16
postexposure prophylaxis for16
with regard to16
treated with a16
the disease course16
hcq may be16
interval prolongation and16
observed in the16
no reuse allowed16
in the original16
in these patients16
need for mechanical16
the strength of16
day followed by16
a multinational registry16
absence of a16
to the intensive16
multinational registry analysis16
fuerte a favor16
data on the16
at least one16
with qtc prolongation16
s c r16
duration of treatment16
of patients had16
prolonged qt interval16
was shown to16
r i p16
uso de la16
that cq and16
in the presence16
c r i16
should be taken16
of hcq azm16
the basis of16
on the antiviral16
de cuidado intensivo16
a n u16
high risk of16
there have been16
be related to16
the proportion of16
allowed without permission16
n u s16
ritonavir in adults16
the pharmacokinetics of16
virus infection in16
retrospective analysis of16
of the s16
replication of sars16
clinical management of16
the cardiovascular system16
admitted to the16
a report of16
control and prevention16
the frequency of16
reuse allowed without16
terminal glycosylation of16
that they have16
i p t16
or hcq in16
into host cells16
increase in qtc16
is the most16
for chloroquine and16
a new coronavirus15
a lack of15
intubation or death15
in healthy volunteers15
that there is15
to be the15
of the participants15
been used for15
are involved in15
association between hcq15
safety of cq15
action of chloroquine15
what to expect15
unidad de cuidados15
a favor fundamento15
interfere with the15
been shown that15
without a macrolide15
of these patients15
in vitro study15
cd t cells15
insights on the15
be effective in15
to be safe15
binding of the15
hcq combined with15
national institutes of15
with other drugs15
either cq or15
as systemic lupus15
patients were treated15
se recomienda realizar15
ingreso a uci15
the beginning of15
to examine the15
added to the15
studies have been15
entry into host15
of hospital stay15
as a therapeutic15
with hcq alone15
in line with15
by interfering with15
daily measured qtc15
those treated with15
of patients who15
no se puede15
have been identified15
in the prevention15
disease control and15
adult patients with15
an in vitro15
the binding of15
is the first15
found that the15
presented in table15
it can be15
effect on the15
differences in the15
la toma de15
in agreement with15
ace and tmprss15
associated with covid15
cohort study of15
una serie de15
part of the15
safe and effective15
and hcq is15
ra and sle15
prevention of covid15
hcq or hcq15
risk of cardiovascular15
the solidarity trial15
the mrna expression15
longest daily measured15
the included reviews15
liu et al15
the ability of15
and hcq for15
use of remdesivir15
azithromycin in the15
qtc interval prolongation15
end of the15
a pesar de15
analysis of cases15
this study is15
modifying antirheumatic drugs15
the viral replication15
in relation to15
for the covid15
clinical course of15
the updated meta15
to the icu15
no se ha15
pharmacologic treatments for15
the study by15
has been associated15
to be associated15
followed by a15
influenza a virus15
the influence of15
or without az15
a history of14
expect for covid14
a mouse model14
treatments for covid14
and torsade de14
may not be14
lpv r and14
treatment options for14
the reduction of14
cases in marseille14
of remdesivir in14
items for systematic14
the pbs group14
favor o en14
to chloroquine and14
a macrolide for14
and hcq with14
replication in vitro14
macrolide for treatment14
infected with novel14
low dose of14
chloroquine against coronavirus14
higher than the14
cq hcq have14
this is a14
label use of14
and management of14
clinical trial hydroxychloroquine14
up to days14
by mg daily14
or chloroquine with14
showed no significant14
was conducted to14
assessment of qt14
a favor o14
that have been14
patients admitted to14
to expect for14
of the qtc14
studies on the14
and risk of14
in vivo studies14
a global pandemic14
manejo de la14
for the novel14
of patients treated14
diagnosis and treatment14
found to have14
patients with hydroxychloroquine14
intervals in a14
was based on14
likely to be14
interpretation of the14
loading dose of14
effective and safe14
with a total14
two of the14
it may be14
inhibition of viral14
chloroquine with or14
should be considered14
clinical trials and14
with an increased14
of chloroquine or14
of cases in14
in case of14
infection with sars14
chen et al14
is required for14
and severe acute14
y en el14
pacientes en el14
significant qtc prolongation14
performed using the14
among patients with14
patients with diabetes14
of qt intervals14
is involved in14
hydroxychloroquine alone or14
patient with systemic14
is responsible for14
attributed to chloroquine14
to predict the14
more likely to14
corona virus disease14
the standard of14
hcq is a14
entry depends on14
la carga viral14
azithromycin on the14
in rheumatic diseases14
treatment of coronavirus14
associated with qtc14
that cq hcq14
coronavirus disease in14
as part of14
of hcq therapy14
in the lungs14
study was conducted14
and hydroxychloroquine for14
o en contra14
mg once daily14
with hydroxychloroquine alone14
fact that the14
the magnitude of14
of a study14
the glycosylation of14
new insights on14
hcq against sars14
the hcq treatment14
patients at risk14
induced qt prolongation14
into the host14
qt intervals in14
been used in14
difference between the14
and mechanical ventilation14
hydroxychloroquine and its14
risk factor for14
cq hcq are14
tlr and tlr14
severity of covid13
there has been13
servicios de salud13
that treatment with13
in cell culture13
infection and progression13
the relationship between13
of the coronavirus13
in the brain13
dependent rna polymerase13
a treatment for13
patients who did13
study of the13
on ace and13
with lower mortality13
associated with qt13
were more likely13
who require oxygen13
authors declare no13
de dificultad respiratoria13
to be used13
cytokine storm and13
recommendations for the13
course of the13
in another study13
we evaluated the13
in the usa13
and pharmacokinetics of13
for use of13
of the host13
been found to13
reported that the13
is blocked by13
routine care data13
los servicios de13
urgent need for13
antiviral activity against13
to compare the13
change in qtc13
a range of13
significantly associated with13
severely ill patients13
to estimate the13
onset of symptoms13
american college of13
of hcq has13
for prophylaxis of13
to fight covid13
of all the13
changes in the13
features of patients13
safety of chloroquine13
in some patients13
comparative study using13
the formation of13
depends on ace13
in an intensive13
dentro de las13
reduction of the13
with these drugs13
was obtained from13
outcomes in patients13
study using routine13
lopinavir ritonavir in13
and it is13
pneumonia who require13
calidad de vida13
effective in the13
with hcq was13
the spread of13
more common in13
of the infection13
treatment and prophylaxis13
critically ill covid13
important to note13
shortness of breath13
of middle east13
based on a13
using routine care13
light of the13
of the medications13
ability to inhibit13
lack of evidence13
infected with covid13
be used as13
patients with pneumonia13
these two drugs13
sars and mers13
the amount of13
were excluded from13
el tratamiento con13
small number of13
with convalescent plasma13
the spike protein13
ph of the13
with mild covid13
which this version13
azithromycin in an13
results of this13
yang et al13
which has been13
observational comparative study13
in a mouse13
of remdesivir for13
is possible that13
patients with chronic13
borba et al13
use of corticosteroids13
and cyp a13
a loading dose13
be explained by13
a role in13
clinical trials in13
flow nasal cannula13
the inclusion criteria13
review on the13
in a retrospective13
todos los pacientes13
arthritis and systemic13
three times daily13
for use in13
a and b13
prophylaxis and treatment13
have been published13
in the literature13
in the disease12
associated with reduced12
immunodeficiency virus type12
as a possible12
rheumatoid arthritis patients12
than cq in12
through the inhibition12
benefit of hcq12
in a randomized12
therapeutic efficacy of12
patients received hcq12
antiviral effect of12
an analysis of12
coronavirus in wuhan12
response to the12
central nervous system12
hydroxychloroquine as available12
erythematosus and rheumatoid12
defined as the12
the risk for12
in which the12
a reduction of12
that of cq12
weapons to fight12
chronic obstructive pulmonary12
la disponibilidad de12
risk of serious12
compared with placebo12
an urgent need12
mayor riesgo de12
new insights into12
outcomes of patients12
higher rate of12
similar to the12
for treating covid12
can result in12
lupus erythematosus patients12
the importance of12
en la uci12
the general population12
cell entry depends12
in subjects with12
patients on hcq12
characteristics of the12
patients were included12
in comparison with12
concomitant use of12
inhibition of sars12
disease severity and12
a control group12
puede emitir una12
majority of the12
were obtained from12
found in the12
during treatment of12
studies hydroxychloroquine and12
a dosis de12
are presented in12
of these medications12
result of the12
and the risk12
of hcq against12
of the manuscript12
this is the12
at the same12
its use in12
para el uso12
with a reduction12
and is blocked12
leads to the12
has been found12
viruses such as12
of azithromycin and12
study conducted in12
characteristics of coronavirus12
del paciente y12
we believe that12
the positive effect12
was approved by12
has been suggested12
en el manejo12
first case of12
available weapons to12
was significantly lower12
a large number12
for each of12
chloroquine in the12
use of the12
the activity of12
of action is12
and chloroquine in12
clinically proven protease12
in the included12
daily dose of12
by a clinically12
and tmprss and12
studies included in12
in association with12
the recovery trial12
prolongation and torsade12
se puede emitir12
hcq on the12
compared to patients12
beneficial effect of12
of hcq mono12
efficacy of these12
high dose of12
clinical trials for12
the differences in12
the spike glycoprotein12
safety profile of12
to standard care12
report of cases12
interfering with the12
efficacy of chloroquine12
of the evidence12
are weak bases12
without azithromycin in12
may have been12
that hcq has12
the percentage of12
clinical trials to12
tissue distribution of12
risk of cardiac12
in the plasma12
creative commons licence12
in the amygdala12
entry into the12
as long as12
that hcq is12
the preferred reporting12
as available weapons12
blocked by a12
either alone or12
personal de salud12
factores de riesgo12
a decrease in12
the two drugs12
los pacientes en12
did not have12
a clinically proven12
type i fipv12
greater than ms12
been demonstrated to12
across the globe12
the study period12
of intubation or12
high levels of12
tmprss and is12
effectiveness of hcq12
compared to placebo12
alone and in12
than in the12
clinical studies hydroxychloroquine12
proven protease inhibitor12
not show any12
may lead to12
viral load reduction12
and of the12
de pacientes en12
el de los12
of these two12
with a combination12
studies have reported12
with hcq in12
identified as a12
with the glycosylation12
that the anti12
would like to12
did not find12
institutes of health12
been linked to12
interferes with the12
hcq was not12
hcq in combination12
hepatitis c virus12
evidence to support11
this drug is11
characteristics and outcomes11
by the spike11
the scientific community11
has been observed11
dosis de mg11
higher in the11
have been conducted11
expression of crh11
a subset of11
use of other11
final de la11
no significant effect11
convalescent plasma therapy11
and the use11
effects on the11
the interpretation of11
shown in table11
hepatitis b virus11
s and s11
the mean age11
after symptom onset11
higher rates of11
factors for mortality11
and duration of11
likely to have11
efficacy of the11
disease in china11
the original data11
the start of11
is likely to11
of action and11
clinical improvement in11
glycosylation of the11
of the sprotein11
treatment in the11
role of chloroquine11
among patients who11
en la mortalidad11
of cq on11
hydroxychloroquine as an11
mg twice a11
transfer to the11
creative commons attribution11
lead to the11
of systematic reviews11
and patients with11
the cytokine storm11
sobre el uso11
hydroxychloroquine and covid11
crh in the11
risk of covid11
que los pacientes11
before and after11
in this article11
hcq was found11
higher proportion of11
study found that11
adult inpatients with11
lessons from the11
was reported by11
in the studies11
it is difficult11
daily on day11
el tiempo de11
utilizar de forma11
can lead to11
of bias in11
shown that the11
in a small11
asai et al11
on day and11
the creative commons11
from malaria to11
all authors have11
animal toxicity and11
prolongation in covid11
drugs for the11
there is currently11
into the antiviral11
and more than11
trial no evidence11
is necessary to11
defined as a11
mortality rate of11
patients with moderate11
found that hcq11
case of covid11
hcq has a11
mortality rate in11
and severity of11
in the same11
angiotensin converting enzyme11
of which are11
in clinical practice11
the data of11
de salud y11
at risk for11
hcq plus az11
term treatment with11
and cq have11
of clinical efficacy11
in autoimmune diseases11
had no significant11
the study of11
in supplementary table11
cq hcq on11
but not in11
was not significantly11
cytokines such as11
was a significant11
taking into account11
in the number11
the antiviral effect11
the aim of11
viral load and11
the active site11
and in combination11
was performed to11
a code for11
a protective effect11
at higher risk11
and cq in11
prevention and treatment11
clinical trial clinical11
in acute respiratory11
the institutional review11
the ability to11
li et al11
was not different11
chloroquine and its11
efficacy against sars11
the current pandemic11
this is an11
on the corrected11
en el contexto11
and chloroquine during11
symptoms of covid11
with cq or11
age and gender11
be more effective11
con el fin11
is difficult to11
those who received11
in a cohort11
chronic treatment with11
twice a day11
fold increase in11
data suggest that11
association of hcq11
treatment in patients11
to hcq and11
positive effect of11
activity of chloroquine11
risk of tdp11
viral entry and11
the same time11
of patients from11
model was used11
fuera de la11
at the beginning11
doses of cq11
analysis revealed that11
a study using11
use for the11
chloroquine for covid11
of cytochrome p11
novel coronavirus from11
in vitro hydroxychloroquine11
clinical trial of11
the purpose of11
we do not11
because of its11
initiation of hcq11
excluded from the11
with a code11
el fin de11
hcq to treat11
a day for11
with pneumonia in11
in the intensive11
of viral particles11
once daily for11
of t cells11
resolution of symptoms11
toxicity and pharmacokinetics11
of mg kg11
and its derivative11
related to covid11
sample size of11
prevention and control11
and congestive heart11
using routinely collected11
surviving sepsis campaign11
lower in the11
cells of the11
in a large11
the patients in11
suggests that the11
side effects and11
of retinal toxicity11
the first trimester11
de la vida11
studies are needed11
risk of developing11
obstructive pulmonary disease11
trial clinical and11
shown to inhibit11
risk of hcq11
ministry of health11
in any of11
viral entry into11
especially in the11
significant differences between11
routinely collected data11
was conducted in11
no difference in11
based on these11
more than one11
the ace receptor11
mortality associated with11
length of hospital11
stages of the11
a median of11
with qt prolongation11
prior to the11
and inhibition of11
been proposed as11
and hydroxychloroquine are11
a significant reduction11
side effect of11
or treatment of11
personal protective equipment10
and use of10
been suggested as10
with hcq monotherapy10
appear to be10
the objective of10
thought to be10
los niveles de10
these drugs for10
higher than that10
in a dose10
a cohort study10
patients with ra10
data to emulate10
authors declare that10
as it is10
drugs for covid10
compared to control10
herpes simplex virus10
en los que10
suggest that hcq10
hcq should be10
in the experimental10
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used in combination10
assessment of the10
use in the10
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qt prolongation in10
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decreased mortality in10
stable binding of10
and prophylaxis of10
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la posibilidad de10
lee et al10
adverse events in10
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of patients receiving10
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for qtc prolongation10
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se recomienda el10
the dose of10
serie de casos10
un estudio retrospectivo10
the mortality rate10
in vitro efficacy10
to account for10
use of this10
the studies included10
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related to hcq10
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health commission of10
mortality of adult10
more potent than10
of this article10
a group of10
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higher risk for10
both hcq and10
severity of illness10
statement from the10
la unidad de10
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diagnosis of covid10
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that it is10
trials for the10
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to emulate a10
clinical trials with10
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the endosomal ph10
of chloroquine phosphate10
por lo que10
hcq plus azithromycin10
on in vitro10
higher probability of10
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and b cells10
collected data to10
decrease in the10
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the reference group10
en cuenta la10
prolonged viral shedding10
evidence of clinical10
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by the fact10
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en el momento10
treatment of systemic10
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inpatients with covid10
an overview of10
whether or not10
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with a significant10
mortality in hospitalized10
the inflammatory response10
on viral load10
el manejo del10
such as rheumatoid10
when compared with10
of our study10
the progression of10
of cardiovascular death10
the drug is10
efficacy against covid10
lopinavir ritonavir and10
los trabajadores de10
was assessed using10
significant increase in10
united states food10
options for covid10
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virus replication in10
se debe considerar10
we found no10
than those in10
for severe covid10
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pointes in patients10
been used as10
the metabolism of10
cq hcq could10
se recomienda considerar10
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under a perpetuity10
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they have no10
which is the10
el consentimiento informado10
on the clinical10
hcq compared to10
is not known10
mhc class ii10
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chronic kidney disease10
are summarized in10
combined with azithromycin10
due to hydroxychloroquine10
could lead to10
of both cq10
an antimalarial drug10
it was not10
exposure to the10
bioavailability of hydroxychloroquine10
the stable binding10
trial efficacy of10
shown to have10
higher in patients10
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early phase of10
are currently being10
adverse event reporting10
there are several10
risk of hospitalization10
is due to10
as prophylaxis for10
in patients in10
centers for disease10
study conducted by10
contributed to the10
pacientes hospitalizados con10
in the analysis10
of hydroxychloroquine tablets10
study using routinely10
risk of intubation10
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patients who died10
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of a novel10
inicio de la10
of hydroxychloroquine treatment10
of hcq az10
the generation of10
qt prolonging medications10
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we used the10
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and heart failure10
the small sample10
se recomienda utilizar10
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was added to10
characteristics of hospitalized10
the in vivo10
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the lpv r10
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with cq hcq10
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evidence of a10
found that cq10
of the combination10
effective in reducing10
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the potential to10
the experimental group10
of adult inpatients10
and lopinavir ritonavir10
evaluation of the10
findings suggest that10
and antiviral activities10
se puede considerar10
a single center10
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course and risk10
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in conjunction with10
pcr para sars10
that cq could9
r and hcq9
and cardiac arrest9
plasma levels of9
of these agents9
remdesivir for patients9
critically ill adults9
of total aes9
viral replication in9
en todos los9
we aimed to9
in preventing infection9
patients with confirmed9
pneumonia in china9
concentrations in the9
web of science9
in the majority9
no statistically significant9
incidence of adverse9
therapy for covid9
syndrome coronavirus infection9
when combined with9
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the type of9
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coronavirus replication in9
levels in patients9
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the potential for9
profesionales de la9
cox proportional hazards9
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in the blood9
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prevention or treatment9
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en pacientes que9
the result of9
the intervention arm9
more than ms9
the relative risk9
on days and9
use of convalescent9
with autoimmune diseases9
activity of the9
la pandemia covid9
macrophage activation syndrome9
reported that hcq9
a statistically significant9
la incidencia de9
the survey was9
reduction of covid9
up to of9
associated with acute9
of remdesivir and9
a systematic search9
median age of9
did not result9
during the study9
it is still9
in these studies9
associated with sars9
qtc prolongation was9
for the diagnosis9
compared with a9
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syndrome coronavirus by9
outside of the9
were performed in9
and torsades de9
a h n9
a descriptive study9
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in response to9
for the next9
hydroxychloroquine tablets in9
in mice and9
with oxygen requirement9
clinical benefit of9
lupus erythematosus hydroxychloroquine9
drugs to treat9
hydroxychloroquine use associated9
the most commonly9
desde el inicio9
and have a9
preliminary results from9
rbd of sars9
of cyclic gmp9
drug for the9
ec values for9
in severe cases9
metabolism of chloroquine9
for this study9
in the low9
analysis of data9
concentrations of cq9
mortality in the9
for acute respiratory9
the clinical efficacy9
required for the9
into two groups9
frequency of lqt9
not in the9
in the time9
and lpv r9
and hcq use9
observational cohort study9
admission to the9
in patients at9
a significant increase9
clinical trial efficacy9
use for covid9
the mice were9
and clinical characteristics9
replication in cell9
protective effect of9
maintenance dose of9
cov and mers9
the middle east9
attributed to the9
infection with oxygen9
as a binary9
of disease severity9
to describe the9
and qtc prolongation9
en tiempos de9
has shown that9
moderate to severe9
in the pbs9
and synthesis of9
course of disease9
hcq and azm9
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mrna expression of9
major congenital malformations9
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de pointes and9
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of this combination9
due to a9
these drugs strongly9
mg on day9
potential inhibitors of9
years of age9
el cual se9
adverse events were9
to severe acute9
treatment in covid9
at increased risk9
evaluate the efficacy9
properties of hcq9
positive for sars9
led to a9
discontinuation of hcq9
of the total9
los efectos adversos9
in saudi arabia9
for critically ill9
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to increase the9
and hcq as9
lack of randomisation9
observational study conducted9
that hcq can9
observational studies and9
influenza a h9
lopinavir and ritonavir9
that the combination9
toma de decisiones9
action of hcq9
the growth of9
indicated that the9
of the ace9
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severe cases of9
studies with a9
of either cq9
cleavage of the9
the american college9
inhibited by hcq9
the assessment of9
controlled clinical trial9
clinical trials of9
green monkey kidney9
the host cells9
una estrategia de9
used in covid9
with a special9
assess the efficacy9
mild to severe9
coronavirus by chloroquine9
examine the effect9
outcomes of critically9
not been reported9
of in vitro9
trials are currently9
risk of malformations9
prolongation and refractory9
hcq with azithromycin9
from the coronavirus9
clinical studies have9
la capacidad de9
effective against sars9
to use hcq9
to patients with9
approved for the9
viral rna synthesis9
from a single9
of drug treatment9
may be due9
in the in9
seen in the9
en cuanto a9
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to the virus9
shown that hcq9
is related to9
ivermectin inhibits the9
hydroxychloroquine in preventing9
cases and controls9
which may be9
is an urgent9
been identified as9
high doses of9
was determined to9
hcq appears to9
be inhibited by9
the difference in9
innate and adaptive9
it is unclear9
patients who have9
que no se9
to the small9
in hospitalised patients9
respiratory failure in9
around the world9
hydroxychloroquine is associated9
in observational studies9
for inhibition of9
is used in9
for novel coronavirus9
these drugs have9
recommendation to examine9
potential risk of9
tener en cuenta9
disease caused by9
and combination in9
of viral load9
transporting polypeptide a9
with hcq with9
boulware et al9
intensive care units9
hcq mg twice9
virological and clinical9
line with the9
of intensive care9
the patients were9
in reducing the9
expression levels of9
summarized in table9
patients suffering from9
luego de la9
treatment of rheumatic9
of which were9
total number of9
for statistical computing9
time of writing9
of data from9
dados de alta9
after a single9
and tumor necrosis9
and prevention of9
a broad spectrum9
are included in9
structure of the9
phase of the9
it is worth9
hcq is not9
the critically ill9
combination of these9
spike glycoprotein and9
of viral replication9
the safety profile9
studies have also9
with mg kg9
exposed to hcq9
associated with disease9
were reported in9
wide range of9
viral clearance and9
the administration of9
management of patients9
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