This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.
| identifier | question |
|---|---|
| cord-003634-iq0e1qp1 | The role of leukocytes following cerebral ischemia: pathogenic variable or bystander reaction to emerging infarct? |
| cord-001675-9717nzr7 | : implications for pandemic influenza preparedness Do viral infections mimic bacterial sepsis? |
| cord-006588-aavpj5r3 | to expired gas NO and bronchial responsiveness in mice Whole body plethysmography, does it measure tidal volumes of small animals? |
| cord-007094-ur9sz21s | Symposium Studies of the mechanism of spontaneous germline ecotropic provirus acquisition in mice Mouse antibody production test: Can we do without it? |
| cord-009388-k3exf8a4 | Rodent models in neuroscience research: is it a rat race? |
| cord-001958-2gt3fwpy | T cell memory Comparison of lyophilized versus liquid modified vaccinia Ankara( MVA) formulations and subcutaneous versus intradermal routes of administration in healthy vaccinia- naive subjects Modified vaccinia virus Ankara as antigen delivery system: how can we best use its potential? |
| cord-254155-860780z9 | The ocular surface and the coronavirus disease 2019: does a dual"ocular route"exist? |
| cord-265299-oovkoiyj | The long view: a bright past, a brighter future? |
| cord-335424-h84jtx94 | Targeting cellular senescence prevents age- related bone loss in mice Karagiannides I. Adipogenesis and aging: Does aging make fat go MAD? |
| cord-023026-2r84ndzv | Does transplantation of healthy endothelial cells have a beneficial effect on the outcome of ischemic brain damage? |
| cord-300372-h5g4z8ts | and T(H)2 inflammation in the pathogenesis of bronchial asthma Influenza-time to target the host? |
| cord-281161-u896icp9 | Any future? |
| cord-312692-jv3425w1 | Middle East respiratory syndrome coronavirus shows poor replication but significant induction of antiviral responses in human monocyte- derived macrophages and dendritic cells Active replication of Middle East respiratory syndrome coronavirus and aberrant induction of inflammatory cytokines and chemokines in human macrophages: implications for pathogenesis Clinicopathologic, immunohistochemical, and ultrastructural findings of a fatal case of Middle East respiratory syndrome coronavirus infection in the United Arab Emirates Kinetics and pattern of viral excretion in biological specimens of two MERS- CoV cases Clinical features and virological analysis of a case of Middle East respiratory syndrome coronavirus infection Updates in the management of acute lung injury: a focus on the overlap between AKI and ARDS MERS transmission and risk factors: a systematic review Distinct immune response in two MERS- CoV- infected patients: can we go from bench to bedside? |
| cord-000539-uh3q65we | A Strain- Dependent Pathogenesis in Fatal H1N1 and H5N1 Subtype Infections of Mice Animal models for the study of influenza pathogenesis and therapy Transmission and pathogenesis of swine- origin 2009 A( H1N1) influenza viruses in ferrets and mice Variations in the Hemagglutinin of the 2009 H1N1 Pandemic Virus: Potential for Strains with Altered Virulence Phenotype? |
| cord-000539-uh3q65we | Pandemic Influenza A( H1N1) Virus Affects Receptor Binding Observed association between the HA1 mutation D222 G in the 2009 pandemic influenza A(H1N1) virus and severe clinical outcome Markers for predicting the development of acute respiratory distress syndrome Radiological prognostic factors in patients with pandemic H1N1( pH1N1) infection requiring hospital admission Serial Histopathological Examination of the Lungs of Mice Infected with Influenza A Virus PR8 Strain Pulmonary surfactant in health and human lung diseases: state of the art Serial changes in surfactant- associated proteins in lung and serum before and after onset of ARDS Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus Induction of proinflammatory cytokines in human macrophages by influenza A( H5N1) viruses: a mechanism for the unusual severity of human disease? |
| cord-299605-j1ewxk4q | The malaria parasite Plasmodium vivax exhibits greater genetic diversity than Plasmodium falciparum Is Plasmodium vivax malaria a severe malaria? |
| cord-292157-hrm69640 | Protected? |
| cord-337464-otwps68u | And Segment Forecasts A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody- secreting hybrid cell lines A better cell line for making hybridomas secreting specific antibodies Human monoclonal antibodies: the emperor's new clothes? |
| cord-267671-ys43n672 | Veterinary Microbiology and Microbial Disease Uteroovarian infection in aged B6C3F1 mice Breast cancer: should gastrointestinal bacteria be on our radar screen? |
| cord-021413-1ht1xm88 | Infantile enteritis viruses: morphogenesis and morphology Is lactase the receptor and uncoating enzyme for infantile enteritis( rota) viruses? |
| cord-021413-1ht1xm88 | This aspect of reovirus 3 infection has been covered above( Section III, B, l,2a, ¿?). |
| cord-348091-pnvn0x4q | Is ethanol- induced damage of the gastric mucosa a hyperosmotic effect? |
| cord-324617-yok7mh70 | The ups and downs of on site immunity Transcutaneous and intradermal vaccination Transcutaneous antigen delivery system Needle- free vaccine delivery Advances in transcutaneous vaccine delivery: Do all ways lead to Rome? |
| cord-314333-hkyiy1gm | Aged BALB/ c mice as a model for increased severity of severe acute respiratory syndrome in elderly humans Is ageing associated with a shift in the balance between type 1 and type 2 cytokines in humans? |
| cord-022393-s26d54ew | A new zoonosis? |
| cord-022393-s26d54ew | In Principles and practices of infectious diseases Laboratory animal allergy in a pharmaceutical company Important animal allergens are lipocalin proteins: why are they allergenic? |
| cord-353190-7qcoxl81 | Different roles for CD4þ and CD8þ T lymphocytes and macrophage subsets in the control of a generalized virus infection Correlates of protective immunity in poxvirus infection: where does antibody stand? |
| cord-306535-j26eqmxt | Isolation and morphological characterization Integrative characterization of germ cell- specific genes from mouse spermatocyte UniGene library Comparative and functional analysis of testis- specific genes Genome engineering uncovers 54 evolutionarily conserved and testis- enriched genes that are not required for male fertility in mice Reaching for high- hanging fruit in drug discovery at protein- protein interfaces Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation Catalytic in vivo protein knockdown by small- molecule PROTACs Hijacking the E3 ubiquitin ligase cereblon to efficiently target BRD4 Lessons in PROTAC design from selective degradation with a promiscuous warhead Assessing different E3 ligases for small molecule induced protein ubiquitination and degradation Cell- penetrating peptides: 20 years later, where do we stand? |
| cord-103703-t03r6ny8 | By what mechanisms might depletion of Tcf7l2 from adipocytes lead to a decrease in the circulating levels of GLP-1 and GIP? |
| cord-103703-t03r6ny8 | Might changes in TCF7L2 expression in adipose tissue contribute to the effects of type 2 diabetes- associated variants? |
| cord-254190-bxfne94u | the complex pathobiology of HIV- associated neurocognitive disorders? |
| cord-254190-bxfne94u | vaccines Humanized mice: are we there yet? |
| cord-288253-wqrhiq08 | what can they teach us about the severe acute respiratory syndrome? |
| cord-320172-qw47pf9r | Immunohistologic analysis of the T- cell and macrophage infiltrate in 1,2-dimethylhydrazine- induced colon tumors in the rat Turnover of brush- border glycoproteins in human intestinal absorptive cells: Do lysosomes have regulatory function? |
| cord-320172-qw47pf9r | Is ethanol- induced damage of the gastric muosa a hyperosmotic effect? |
| cord-292402-u3sfc1yz | ( What are the components of the reticular fibers, and which cells in the CNS produce the components?), still remain to be answered. |
| cord-292402-u3sfc1yz | The immunological synapse: a focal point for endocytosis and exocytosis Chemokines: a new class of neuromodulator? |
| cord-292596-ulu5y140 | Emerging evidence for a functional angiotensin- converting enzyme 2-angiotensin-(1- 7)-MAS receptor axis: more than regulation of blood pressure? |
| cord-292596-ulu5y140 | Vascular protective effects of angiotensin converting enzyme inhibitors and their relation to clinical events Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress Liver fibrosis: a balance of ACEs? |
| cord-326223-q6e60nf8 | Enhanced renal immunocytochemical expression of ANG-(1- 7) and ACE2 during pregnancy Novel aspects of the renal renin- angiotensin system: angiotensin-(1- 7), ACE2 and blood pressure regulation Vasopeptidase inhibitors: a new therapeutic concept in cardiovascular disease? |
| cord-326223-q6e60nf8 | The angiotensin- converting enzyme gene family: genomics and pharmacology Hydrolysis of biological peptides by human angiotensin- converting enzyme- related carboxypeptidase AT1 receptor blockade increases cardiac bradykinin via neutral endopeptidase after induction of myocardial infarction in rats Vasopeptidase inhibitors: will they have a role in clinical practice? |
| cord-288133-h3wmo0xj | The context specificity of anxiety responses induced by chronic psychosocial stress in rats: a shift from anxiety to social phobia? |
| cord-288133-h3wmo0xj | The effect of handling method on the mouse grimace scale in two strains of laboratory mice Cage enrichment with paper tissue, but not plastic tunnels, increases variability in mouse model of asthma Happy animals make good science Effects of cage- change frequency and bedding volume on mice and their microenvironment Stress and distress Corticotropin- releasing factor in the hippocampus: eustress or distress? |
| cord-256998-or73in8m | After initial setback, IL-12 regaining popularity Interleukin 12: still a promising candidate for tumor immunotherapy? |
| cord-256998-or73in8m | Gamma interferon enhances macrophage transcription of the tumor necrosis factor/ cachectin, interleukin 1, and urokinase genes, which are controlled by short- lived repressors Interferon and major histocompatibility complex genes: a model to analyse eukaryotic gene regulation? |
| cord-256998-or73in8m | The molecular pathogenesis of semliki forest virus: a model virus made useful? |
| cord-015147-h0o0yqv8 | Here we report on the development of the PGE2 mimetic combination therapy( DP-837953) that inhibits basal and LPS/ TLR4 induced TNF-?, IL-1ß, and MMP-1, 8, 9, 13 in human and murine synovial membranes and peripheral macrophages. |
| cord-015147-h0o0yqv8 | In a murine model of chronic synovitis( dorsal skin air pouch), DP837953 dramatically inhibited IL-1ß, TNF-?, MIP2, MCP-2 and IL-8 expression, delayed the profile of leukocyte/ neutrophil extravasation and reduced exudate volume. |
| cord-015147-h0o0yqv8 | In addition, TNF-?, IL-1ß, MMP-8 and to a lesser extent MMP-9 expression/ synthesis levels were strongly suppressed as judged by RT- PCR and ELISA measurements |
| cord-015147-h0o0yqv8 | Most of the recent studies have focused on challenge- induced expression of antimicrobial peptides and have addressed the following questions:( 1) which genes are upregulated during various types of bacterial, fungal or viral infections and what are their functions? |
| cord-022353-q2k2krnm | A mouse bleeding technique yielding consistent volume with minimal hemolysis Transgenesis and the study of expression, cellular targeting, and function of oxytocin, vasopressin and their receptors KOs model the 100 best- selling drugs: will they model the next 100? |
| cord-022353-q2k2krnm | Insights in asthma from overexpression transgenic modeling Genotype, obesity, and cardiovascular disease: has technical and social advance outstripped evolution? |
| cord-022353-q2k2krnm | Mildly oxidized LDL induces an increase apolipoprotein J/ paraoxonase ration The genetic control of alkaline phosphatase activity in the duodenum of the mouse Diabetes mellitus: a"thrifty"genotype rendered detrimental by"progress"? |
| cord-022353-q2k2krnm | The protein profile of acetazolamidetreated sera in mice bearing Lewis neoplasm CEBS object modes for systems biology data, SysBio- OM Partal hormone resistance in mice with disruption of the steroid receptor coactivator-1( SRC-1) gene Platelet factor 4 gene transfection into tumor cells inhibits angrogenesis tumor growth and metastasis Mice lacking the thyrotropin- releasing hormone gene: what do they tell us? |
| cord-007726-bqlf72fe | Allergic airway inflammation initiates long- term vascular remodeling of the pulmonary circulation Respiratory allergy caused by house dust mites: what do we really know? |
| cord-007726-bqlf72fe | The laboratory mouse A comparative encyclopedia of DNA elements in the mouse genome Principles of regulatory information conservation between mouse and human Of mice and men: aligning mouse and human anatomies Mouse models of human disease: an evolutionary perspective Structure and composition of pulmonary arteries, capillaries, and veins Angiogenesis in the mouse lung Lung cancer perfusion: can we measure pulmonary and bronchial circulation simultaneously? |
| cord-007726-bqlf72fe | The transition from primary culture to spontaneous immortalization in mouse fibroblast populations Studying human respiratory disease in animals-role of induced and naturally occurring models Role of mast cells in allergic and non- allergic immune responses: comparison of human and murine data Allergic airway inflammation induces migration of mast cell populations into the mouse airway Novel site- specific mast cell subpopulations in the human lung Animal models of asthma: reprise or reboot? |
| cord-007726-bqlf72fe | What Does the Future Hold for Mouse Models of Human Disease? |
| cord-351011-v4zmksio | The pathogenesis and treatment of the` Cytokine Storm'in COVID-19 The many faces of the anti- COVID immune response Neuromechanisms of SARS- CoV-2: A Review Early recovery following new onset anosmia during the COVID-19 pandemic-an observational cohort study Does SARS- Cov-2 invade the brain? |
| cord-351011-v4zmksio | The use of anti- inflammatory drugs in the treatment of people with severe coronavirus disease 2019( COVID-19): The 590 Perspectives of clinical immunologists from China Severe COVID-19 and aging: are monocytes the key? |
| cord-351011-v4zmksio | increases lung inflammation and activates pulmonary microvascular endothelial cells via an IL-4-dependent mechanism Protection of LPS- induced murine acute lung injury by sphingosine-1-phosphate lyase suppression Sphingolipids in Ventilator Induced Lung Injury: Role of Sphingosine-1-Phosphate Lyase Endothelial cell infection and endotheliitis in COVID-19 Effective treatment of severe COVID-19 patients with tocilizumab Macrophages: a Trojan horse in COVID-19? |
| cord-354325-r73datur | A role for infectious tolerance? |
| cord-354325-r73datur | How do monoclonal antibodies induce tolerance? |
| cord-354325-r73datur | Tyrosine kinase inhibitors targeted to the epidermal growth factor receptor subfamily: role as anticancer agents Are solid tumor anti- idiotype vaccines ready for prime time? |
| cord-022082-1dq623oe | A toxicological study Epididymal and systemic phospholipidosis in rats and dogs treated with the dopamine D3 selective antagonist PNU-177864 Myopathy related to administration of a cationic amphiphilic drug and the use of multidose drug distribution analysis to predict its occurrence Drug- induced phospholipidosis: are there functional consequences? |
| cord-022082-1dq623oe | The specificity of the high endothelial venule in bronchus- associated lymphoid tissue( BALT) T cells and T cell subsets in rat bronchus associated lymphoid tissue( BALT) in situ and in suspension Have you seen this?' |
| cord-022082-1dq623oe | Two distinct patterns Interstitial pneumonitis associated with bleomycin therapy Bleomycin lung toxicity: who are the patients with increased risk? |
| cord-022082-1dq623oe | What are the imphcations for humans of drugs that induce phosphohpidosis in laboratory animals? |
| cord-022082-1dq623oe | What can the biology of small cell cancer of the lung teach us about the endocrine lung? |
| cord-353600-5wo74ms4 | : between immune cells depletion and cytokines up- regulation Is the oxidative stress theory of aging dead? |
| cord-353600-5wo74ms4 | Attenuated superoxide dismutase 2 activity induces atherosclerotic plaque instability during aging in hyperlipidemic mice Antioxidants in cardiovascular therapy: panacea or false hope? |
| cord-353600-5wo74ms4 | The hallmarks of aging Oxidative stress in atherosclerosis Is pulse pressure useful in predicting risk for coronary heart disease? |
| cord-353600-5wo74ms4 | alleviates established vasomotor dysfunction in aged or atherosclerotic mice Metformin as antiaging therapy: is it for everyone? |
| cord-319933-yp9ofhi8 | * Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome SARS vaccines: where are we? |
| cord-319933-yp9ofhi8 | An unusual hantavirus outbreak in southern Argentina: person- to- person transmission? |
| cord-319933-yp9ofhi8 | Efficacy assessment of a cell- mediated immunity HIV-1 vaccine( the step study): a double- blind, randomised, placebo- controlled, test- of- concept trial Human papillomavirus in cervical cancer Human papillomavirus research: do we still need animal models? |
| cord-319933-yp9ofhi8 | Phenotypic changes in Langerhans'cells after infection with arboviruses: a role in the immune response to epidermally acquired viral infection? |
| cord-347039-eap592i7 | Are MHC proteins cellular receptors for CMV? |
| cord-347039-eap592i7 | I fold a recognition- associated structure? |
| cord-347039-eap592i7 | Important questions to be answered include:( 1) Do other activating NK- cell receptors have specialized functions in virus recognition? |
| cord-347039-eap592i7 | What is the extent of the repertoire of target molecules for NK- cell- activating receptors? |
| cord-031279-8rckjc41 | A novel inflammation- related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate Rewilding Nod2 and Atg16l1 mutant mice uncovers genetic and environmental contributions to microbial responses and immune cell composition Altered immunity of laboratory mice in the natural environment is associated with fungal colonization New insights into the immune system using dirty mice Housing temperature- induced stress is suppressing murine graft- versus- host disease through beta2-adrenergic receptor signaling Translating animal model research: does it matter that our rodents are cold? |
| cord-031279-8rckjc41 | RALDH+ dendritic cells Precolonization with the commensal fungus Candida albicans reduces murine susceptibility to Clostridium difficile infection Review series on helminths, immune modulation and the hygiene hypothesis: immunity against helminths and immunological phenomena in modern human populations: coevolutionary legacies? |
| cord-031279-8rckjc41 | Revised estimates for the number of human and bacteria cells in the body Are we really vastly outnumbered? |
| cord-031279-8rckjc41 | The impact of a helminth- modified microbiome on host immunity Gut protozoa: friends or foes of the human gut microbiota? |
| cord-031279-8rckjc41 | pathology and pathogenesis Will the increased prevalence of nonalcoholic steatohepatitis( NASH) in the age of better hepatitis C virus therapy make NASH the deadlier disease? |
| cord-308461-4lhh3du0 | 17 Fix the thoracic suction window to the holding block at a 90 ° angle and put a round cover glass on the tip of the suction device.? |
| cord-308461-4lhh3du0 | 6 Launch the Aligna 4D control software Kangoo and adjust the laser path connecting the laser source unit and the microscope( Supplementary Fig. 4).? |
| cord-308461-4lhh3du0 | Subsequently, transfer the mouse to the hot plate while supplying 2% isoflurane via an anesthetic mask.? |
| cord-308461-4lhh3du0 | Wearing a Tyvek suit, positive pressure mask, and gloves according to the guidelines for the BSL3 facility, enter the BSL3 facility where the imaging system is housed.? |
| cord-308461-4lhh3du0 | When an infected animal is not used, an administration route can be created via the tail vein or the jugular vein.? |
| cord-264408-vk4lt83x | ( l- sIGN) is a receptor for severe acute respiratory syndrome coronavirus Glycomic characterization of respiratory tract tissues of ferrets: implications for its use in influenza virus infection studies Comparative analysis of monkeypox virus infection of cynomolgus macaques by the intravenous or intrabronchial inoculation route Phenotypic changes in langerhans'cells after infection with arboviruses: a role in the immune response to epidermally acquired viral infection? |
| cord-264408-vk4lt83x | A novel model of lethal Hendra virus infection in African green monkeys and the effectiveness of ribavirin treatment Clinical outcome of henipavirus infection in hamsters is determined by the route and dose of infection recent progress in henipavirus research: molecular biology, genetic diversity, animal models Mucosal arenavirus infection of primates can protect them from lethal hemorrhagic fever sArs vaccines: where are we? |
| cord-264408-vk4lt83x | A simple technique for infection of mosquitoes with viruses; transmission of Zika virus Human papillomavirus research: do we still need animal models? |
| cord-264408-vk4lt83x | An unusual hantavirus outbreak in southern Argentina: person- to- person transmission? |
| cord-264408-vk4lt83x | emerg sArs: what have we learned? |
| cord-022888-dnsdg04n | /CRTAM on gd T cells? |
| cord-022888-dnsdg04n | As the results show, could there not be a direct relationship between the HLA system and the development of SA or TBC, or in contrast, was the first patient missdiagnosed of TBC being a good prognosis SA? |
| cord-022888-dnsdg04n | Could Carabin play a role of negative regulator of B cell function? |
| cord-022888-dnsdg04n | How is the IGSF4-CRTAM axis regulated in T cells? |
| cord-022888-dnsdg04n | a one- year prospective birth cohort study PC09/16 TO WHAT EXTENT T- SPOT.TB COULD BE USED IN THE DIAGNOSIS OF TUBERCULOSIS IN CHILDREN EXPOSED TO TB INFECTION? |
| cord-278136-ol2buwld | He began his lecture with the quote''Are we letting a philosophy of the protein- coding gene control( our) reasoning? |
| cord-278136-ol2buwld | How can we ensure that future generations of biologists are adequately trained to evaluate statistical methods? |
| cord-278136-ol2buwld | Speakers in the first session discussed their experiences with single- cell RNA- seq to address a series of questions that remain integral to the IMGC each year; namely, what tools and technologies are driving our field forward? |
| cord-278136-ol2buwld | What exciting possibilities do they create, and what obstacles do we face in using these methods and interpreting their results? |
| cord-278136-ol2buwld | What then is the philosophy of the gene?'' |
| cord-278136-ol2buwld | When the same data can be analyzed to show very different results, potentially affecting funding decisions on models, is the ultimate onus for publication on the journal or expert scientific reviewers? |
| cord-004879-pgyzluwp | A50$ 14- 28 Neutralization rates of TNF- a from eight animal species by a monoclonal antibody against human TNF: implication for receptor action? |
| cord-004879-pgyzluwp | Are these two activities encoded by a single mRNA? |
| cord-004879-pgyzluwp | Do their protein- chemical structure and organisation decipher us certain clues and parts of the path by which they have been selected and derived from a possible primordial reaction centre polypeptide? |
| cord-004879-pgyzluwp | Does the ALEP1 germ- line specific protein have a homologue in the somatic ribosomes? |
| cord-004879-pgyzluwp | However, in the presence of 1000 U/ ml interferon? |
| cord-004879-pgyzluwp | Is membranebound enzyme preferentially associated with a given cellular membrane? |
| cord-004879-pgyzluwp | What is the function of rpS 19? |
| cord-006230-xta38e7j | 2´-deoxy- cAMP in human cell lines: Another second messenger? |
| cord-006230-xta38e7j | > Ser Extra- adrenal glucocorticoid synthesis in the intestinal epithelium: more than a drop in the ocean? |
| cord-006230-xta38e7j | Converging of the classical mitochondria- related pathway in Parkinson and nuclear DNA- repair signaling? |
| cord-006230-xta38e7j | Detoxification by conjugation of glutathione? |
| cord-006230-xta38e7j | Is formaldehyde a good example for a"genotoxic carcinogen"with a threshold mode of action? |
| cord-006230-xta38e7j | The transcriptome analyses of human cells showed that additionally to the 30.000 protein coding sequences the human DNA codes for much more( 450.000?) |
| cord-006230-xta38e7j | possible link between diabetes and cancer? |
| cord-023143-fcno330z | *? |
| cord-023143-fcno330z | , Cara Wilsont, Kelledy Mansons, Michael Wyands, Bruce Walker?, Ronald C. Desrosiers |
| cord-023143-fcno330z | However, productive virus replication is minimized by antiviral CD8 T cells which suppress( kill?) |
| cord-023143-fcno330z | PrP genes were used to demonstrate that the"specie9 bank?' |
| cord-023143-fcno330z | The interferons( IFNs) a n? a family of cytokines whose functions include the protection of cells against viral infection. |
| cord-023143-fcno330z | Thes? |
| cord-023143-fcno330z | ofthe influenza HA protein from this second promoter in baby hamster kidney( BHK) cells was approximately 50?? |
| cord-023143-fcno330z | ofthe influenza HA protein from this second promoter in baby hamster kidney( BHK) cells was approximately 50?? |
| cord-006229-7yoilsho | But what would happen if the HFD was switched to normal pellet diet in these diabetic rats? |
| cord-006229-7yoilsho | Core or coating material? |
| cord-006229-7yoilsho | Increased GABA release in human neocortex at high intracellular sodium and low extracellular calcium-an anti- seizure mechanism?] |
| cord-006229-7yoilsho | Occasionally there are specific questions occurring on the ruminant xenobiotic metabolism: 1) are the observed metabolites ruminant specific and formed directly in the rumen? 2) are ruminants able to cleave plant specific metabolites like glycosides to the respective aglycon? |
| cord-006229-7yoilsho | Occasionally there are specific questions occurring on the ruminant xenobiotic metabolism: 1) are the observed metabolites ruminant specific and formed directly in the rumen? 2) are ruminants able to cleave plant specific metabolites like glycosides to the respective aglycon? |
| cord-006229-7yoilsho | The data point to a role of Rac1-regulated filamentous( nuclear?) |
| cord-006229-7yoilsho | The γH2AX Assay for Genotoxic and Nongenotoxic Agents: Comparison of H2AX Phosphorylation with Cell Death Response Perturbation of mitosis through inhibition of histone acetyltransferases: the key to ochratoxin a toxicity and carcinogenicity? |
| cord-006229-7yoilsho | Vitamin D metabolism-Involved in triazole fungicide toxicity? |
| cord-006229-7yoilsho | What dictates the uptake and translocation of nanoparticles in vitro? |
| cord-006229-7yoilsho | What would happen without this exception? |
| cord-023055-ntbvmssh | -%~~ specific? |
| cord-023055-ntbvmssh | D61 and D62 are 9 and 13 bp long, are frequently recombine as D,1/ D62? and reveal exonucleolytic trimning with extensive"N"segment addition. |
| cord-023055-ntbvmssh | In support of this possibility, thymectomized&+( a x b)F1 chimeras given strain J? marrow cells and a strain thymus graft( irradiated) show no detectable tolerance to host- type strain b determinants: the strain& CD4+ cells differentiating in these chimeras give strong MLR to strain b and do not show deletion of v 11+ cells. |
| cord-023055-ntbvmssh | The efect of these TCR differences on recognition was assessed using a pane? |
| cord-023055-ntbvmssh | The existence of"primed"T cells in phenotypically tolerant animals raises the possibility that precocious activation of TR1( by neonatal exposure to tolerogen?) suppresses the later emergence of T,,, which would be expected to contain the cells responsible for graft rejection. |
| cord-023055-ntbvmssh | The increase peaked at 2 min and returned almost to baseline by 10 mi?. |
| cord-023055-ntbvmssh | Us& this tecfinolosy we have begun to characterize the irmnUne reqonse to individual peptide antigens.? |
| cord-023055-ntbvmssh | Us& this& logy we have begun to characterize the innume response to individual Peptide antigens.? |
| cord-023055-ntbvmssh | We have extended these exper- to inta? |
| cord-023055-ntbvmssh | We reasoned that given the potential for direct peptide/ class?'&$% ation observed in vifro, OVA2s,-2ra may induce CTL after in vivo priming. |
| cord-023055-ntbvmssh | c a l l y autoreactive T cell:? |
| cord-023055-ntbvmssh | e human nutoinimiine tlisrases maintdin:? |
| cord-287670-z6ckhkgg | A Balancing Act? |
| cord-287670-z6ckhkgg | Does PTX3 play differential or redundant roles in diverse forms of cancer? |
| cord-287670-z6ckhkgg | For which different types of virus does PTX3 facilitate viral entry? |
| cord-287670-z6ckhkgg | In what immediate conditions can PTX3 be assessed? |
| cord-287670-z6ckhkgg | Is there an underlying functional advantage in response to these different scenarios for the host? |
| cord-287670-z6ckhkgg | What impact does it have in mediating antiviral defense versus facilitating viral entry? |
| cord-287670-z6ckhkgg | What is the impact of PTX3 as a genetic or circulating protein marker on disease management for specific clinical conditions? |
| cord-287670-z6ckhkgg | What is the mechanistic basis for the observed antagonistic effects of PTX3 in response to varying bacterial burdens during an infection and is there a threshold? |
| cord-287670-z6ckhkgg | What is the mechanistic basis of the oncosuppressive role of PTX3 in various forms of cancer? |
| cord-287670-z6ckhkgg | What is the role of PTX3 in antiviral resistance? |
| cord-287670-z6ckhkgg | What is the role of complement in carcinogenesis and human cancer? |
| cord-287670-z6ckhkgg | What is the therapeutic potential of PTX3 in specific microbial infections( e.g., Aspergillus fumigatus, Pseudomonas aeruginosa)? |
| cord-287670-z6ckhkgg | Would this phenomenon apply to different pathogens? |
| cord-287670-z6ckhkgg | [ 8][ 9]? |
| cord-287670-z6ckhkgg | key: cord-287670-z6ckhkgg authors: Magrini, Elena; Mantovani, Alberto; Garlanda, Cecilia title: The Dual Complexity of PTX3 in Health and Disease: A Balancing Act? |
| cord-257167-rz4r5sj7 | ( 1) Which type of brain infarction will be a future target of this therapeutic approach? |
| cord-257167-rz4r5sj7 | ( 2) Which phase of brain infarction( i.e., acute or chronic phase) will be selected as a future timing of therapeutic intervention? |
| cord-257167-rz4r5sj7 | ( 3) Which will be the best way to be applied in the clinical settings, neurogenesis control, stem cell supply or both? |
| cord-257167-rz4r5sj7 | Are NSF and VCP playing complementary or antagonistic roles? |
| cord-257167-rz4r5sj7 | How are brains controlled molecularly? |
| cord-257167-rz4r5sj7 | How can a material object became aware of the world around it and of its very own awareness? |
| cord-257167-rz4r5sj7 | How do pictorial cues influence 3D information processing in the parietal association cortex? |
| cord-257167-rz4r5sj7 | How do these neurons integrate signals from V1? |
| cord-257167-rz4r5sj7 | How do we deal with timing in the brain? |
| cord-257167-rz4r5sj7 | How do we determine what is good or bad for the maturing brain? |
| cord-257167-rz4r5sj7 | How does the brain order successive events? |
| cord-257167-rz4r5sj7 | How is olfactory receptor- dependent axonal wiring conducted? |
| cord-257167-rz4r5sj7 | How relevant is it in protein synthesis- dependent late- phase plasticity( LP)? |
| cord-257167-rz4r5sj7 | In particular, does the well- known columnar organization of V1 play a role in determining the shape selectivity of higher- order neurons? |
| cord-257167-rz4r5sj7 | It is open question, however, if the brain correctly compensates the difference of the relative position of eyes to the head? |
| cord-257167-rz4r5sj7 | JST.ERATO, HFSP SY2- 2- 08- 4 Why look there? |
| cord-257167-rz4r5sj7 | PS3P- G101 Is"seronegative"MG explained by autoantibodies to MuSK? |
| cord-257167-rz4r5sj7 | Thirty tasks were presented visually every 30 s, the subjects were asked to think about the question immediately following the sentences and asked not to think moreover if the question was difficult( e.g., How to cook curried rice? |
| cord-257167-rz4r5sj7 | This raises urgent and important ethical questions for our consideration: is there an"ideal"brain we should be nurturing? |
| cord-257167-rz4r5sj7 | To what extent can/ should drugs be used not merely to correct developmental disorders but also to enhance performance? |
| cord-257167-rz4r5sj7 | Which is essential? |
| cord-257167-rz4r5sj7 | Why do we look where we do? |
| cord-257167-rz4r5sj7 | or How to fold paper into a turtle? etc). |
| cord-015021-pol2qm74 | ( 3) Should future clinical trials be based on new classifications of illness such as MODS, SIRS, APACHE III, SAP II, MRM, etc., or should trials be dedicated to specific diseases-urinary tract infections, pneumonia, trauma patients, cardiac surgery and other specific problems, rather than generalized problems of sepsis, the sepsis syndrome and other classifications? |
| cord-015021-pol2qm74 | 3-Is the ACCP classification of sepsis useful at the bedside to select oatients? |
| cord-015021-pol2qm74 | Abnormally high skeletal muscle pO 2 in septic patients and its normalization during recovery: Evidence against tissue hypoxia but for impaired oxygen metabolism of skeletal muscle? |
| cord-015021-pol2qm74 | Administration of exogenous IFN? |
| cord-015021-pol2qm74 | And, finally, how can the participants be sure that the trial will be stopped at the right time, to ensure that no treatment is given to any patient that might be harmful? |
| cord-015021-pol2qm74 | Are all eligible patients being studied, and their results reported? |
| cord-015021-pol2qm74 | Are all the participants truly unbiased about the relative merits of the regimens being studied? |
| cord-015021-pol2qm74 | Before using the model for risk of death in septic patients, is it mandatory to validate it( by calibration, i.e. goodness of fit, and discrin'dnation, i.e., ROC curves) first on a data base using the same definition for sepsis as in the trial and secondly on the placebo group of the trial? |
| cord-015021-pol2qm74 | Can it achives a significant improvement in the septic course, organ dysfunction, and final outcome? |
| cord-015021-pol2qm74 | Conversely, administration of anti- IFN? |
| cord-015021-pol2qm74 | Correlatively the RNI inhibitor MMLA induces in vitro a decrease in the rate of bacterial killing, fxom 78% to 57%, in macrophages triggered with IFN-?+ LPS. |
| cord-015021-pol2qm74 | How can organ dysfunction and/or failure be defined? |
| cord-015021-pol2qm74 | How should we decide which of them should be brought to clinical trial? |
| cord-015021-pol2qm74 | If there is agreement that thin is an appropriate antibiotic protocol, should it not be used in all seriously ill septic patients in the hospital? |
| cord-015021-pol2qm74 | In contrast, GF109203X significantly reduced ICAM-1 expression induced by Interferon- y( IFN-?) |
| cord-015021-pol2qm74 | In fact, the IFN-? and IL-1 induced adhesion of PBMC to cytokine treated HUVEC could be downregulated by the PKC- inhibitor, whereas TNFc~-and LPS- mediated adhesion was not influenced. |
| cord-015021-pol2qm74 | In other words, should we now begin to have clinical trials on specific diseases with causes that are known and can be attacked? |
| cord-015021-pol2qm74 | Interferon-? |
| cord-015021-pol2qm74 | Is like being compared with like-are all the end points and the standards for measuring them clearly defined so that they can not be misunderstood? |
| cord-015021-pol2qm74 | Is there any role for antioxidative therapy in sepsis? |
| cord-015021-pol2qm74 | Is truly informed consent being sought that will satisfy not only the patient's right to choose what happens to him, but also the law of the land? |
| cord-015021-pol2qm74 | MIF secretion also was induced by TNFoc( 1 ng/ ml) and IFN? |
| cord-015021-pol2qm74 | MIF secretion is induced by LPS, TNFc~ and IFN?. |
| cord-015021-pol2qm74 | Macrophages of C57BL/10ScCr mice are incapable of producing interferon-~( IFN~) which we could show to be obligatory for the production of IFN? |
| cord-015021-pol2qm74 | On closer investigation the impaired IFN? |
| cord-015021-pol2qm74 | The IFN? |
| cord-015021-pol2qm74 | The absence of sensitization to LPS in Lps d C57BL/10ScCr mice was identified as being due to their inability to produce interferon-7( IFN?). |
| cord-015021-pol2qm74 | The clinical"take"rate o? cultured epithelial autografts( CEA) has been observed to Increase with transplantation to allodermls, but the reasons for the improved clinical performance have not yet been defined. |
| cord-015021-pol2qm74 | The inability to produce adequate amounts of IL-2, most likely attributable to alterations in the transmission of signals from the cell membrane to the nucleus, results in incomplete proliferative T- cell responses to antigenic stimuli, while a lack of? |
| cord-015021-pol2qm74 | There are reports of nentrophil dysfunction in inflammatory disorders of the skin( 2), Are there dysfunctions concerning the unspecific host defense in SIRS, as well? |
| cord-015021-pol2qm74 | This has not happened, however, and the question is"Why not"? |
| cord-015021-pol2qm74 | This might be due to a preexisting( genetic?) or more likely to an epiphenomenal receptor defect. |
| cord-015021-pol2qm74 | We have investigated the proinflaznmatory oytokine secretion patter~ by PMN in patients following major~hermal or tra~ matic injury and in volunteers fellowinq endotoxemia.? |
| cord-015021-pol2qm74 | What are the definitions? |
| cord-015021-pol2qm74 | What are the issues, then, in 1994, to be dealt with at this symposium and congress? |
| cord-015021-pol2qm74 | What are the mechanisms? |
| cord-015021-pol2qm74 | What is the aplpiieability of study results in typical clinical situations? |
| cord-015021-pol2qm74 | What is the availability of speciftc antibiotics at a participating hospital? |
| cord-015021-pol2qm74 | Will the patient's physicians agree to the protocol choice? |
| cord-015021-pol2qm74 | Will they be helpful in the study and esro of patients? |
| cord-015021-pol2qm74 | Will this contribute to better clinical trials, information basis and better research? |
| cord-015021-pol2qm74 | Will we benefit Oleo from a more precise classification and definition of a non- outjty, a hodgu- podge of human disorders which have charsmeristic.s and manifestations of tissue injury, inflammation and infactian? |
| cord-015021-pol2qm74 | and?-IFN and T- helper-2( Th2) acting principally in inducing antibody formation with a secretion of IL-4, IL-5, IL-10 and TNF-[3 has still to be established within the context of major trauma. |
| cord-015021-pol2qm74 | anti- IFN-?( p<0.05). |
| cord-015021-pol2qm74 | or is it better to use a specific model for each trial? |
| cord-015021-pol2qm74 | ~is s?. |