This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.
| identifier | question |
|---|---|
| cord-007755-o2r8ktie | Can we infer peptide recognition specifi city mediated by SH3 domains? |
| cord-002394-n85ptr5p | What's new? |
| cord-022499-7d58f1k3 | The structure of the potassium channel: Molecular basis of K+ conduction and selectivity Molecular sorting of lipids by bacteriorhodopsin in dilauroylphophatidylcholine/ distearoylphosphatidylcholine lipid bilayers Is the protein/ lipid hydrophobic matching principle relevant to membrane organization and functions? |
| cord-003020-q69f57el | Why OppA protein can bind sequence- independent peptides? |
| cord-013952-zp4q3ztr | an angiotensin II receptor antagonist Does activation of the protective renin- angiotensin system have therapeutic potential in COVID-19? |
| cord-024193-khdvj6t5 | However, the most interesting scientific question in biomarker discovery is as follows: can we find novel antigens and their corresponding antibodies without previous knowledge about the antigen? |
| cord-262748-v4xue7ha | Virus membrane- fusion proteins: more than one way to make a hairpin Can self- inhibitory peptides be derived from the interfaces of globular protein- protein interactions? |
| cord-305755-6jup93v4 | The human nasal microbiota and Staphylococcus aureus carriage Evaluation of Sample Preparation Methods for Fast Proteotyping of Microorganisms by Tandem Mass Spectrometry Mass spectrometry: a revolution in clinical microbiology? |
| cord-252147-bvtchcbt | Is declining innovation in the pharmaceutical industry a myth? |
| cord-003033-nlaiurau | In Vivo Small- molecule- biased formyl peptide receptor agonist compound 17b protects against myocardial ischaemia- reperfusion injury in mice Update on ischemia- reperfusion injury in kidney transplantation: Pathogenesis and treatment When a Transplant Fails Ischemia/ reperfusion- associated tubular cells injury in renal transplantation: Can metabolomics inform about mechanisms and help identify new therapeutic targets? |
| cord-003033-nlaiurau | formyl peptide receptors novel targets for therapeutic intervention in ischaemia- reperfusion injury? |
| cord-340971-e42g37la | Why? |
| cord-348432-6jgao58w | The interesting question then, is how strong will the immune response be when a PEGylated peptide aggregates? |
| cord-333262-xvfl7ycj | ( G?) means an optional glycine insertion. |
| cord-298019-gf2asni1 | The preference of tryptophan for membrane interfaces Use of hydrophobic moment plot methodology to aid the identification of oblique orientated α- helices Antimicrobial peptides and viral fusion peptides: how different they are? |
| cord-343791-0vykwml5 | With several self- assembling platforms being discovered and developed over the past 50 years, it is worth considering the cross- roads that lay ahead: should we focus on the development of the promising platforms discussed here, or should we continue searching for new, novel platforms? |
| cord-023208-w99gc5nx | Are aza- β3 amino acids γ- turn mimetics? |
| cord-023208-w99gc5nx | These cells were multilayered on day-3 and expressed various keratinocyte markers, including cytokeratin-1, involculin, and laminin? |
| cord-018401-josb16pi | The"correctly- folded"state of proteins: Is it a metastable state? |
| cord-018401-josb16pi | molecular recognition of paraoxon in Langmuir films Influence of pH and pyrenyl on the structural and morphological control of peptide nanotubes Bioorganic chemistry Neurotoxic effects of thioflavin S- positive amyloid deposits in transgenic mice and Alzheimer's disease Is congo red an amyloid- specific dye? |
| cord-332003-67e9fchy | Heparan sulfate proteoglycan as a cell- surface endocytosis receptor Glycosaminoglycans in the cellular uptake of drug delivery vectors-bystanders or active players? |
| cord-022955-vy0qgtll | A key question is how is the multi- ubiquitin chain is recognized as a signal? |
| cord-022955-vy0qgtll | Is this brain protease involved in the pathomechanism of multiple sclerosis? |
| cord-339879-92esdjy9 | Interferon production by t4 coliphage Bacterial viruses as human vaccines? |
| cord-316474-407bthqj | Is there any pattern exists in propagationrelated TUPs? |
| cord-320693-de1lmzl1 | : do they have a future as therapeutics? |
| cord-000264-o80duxhs | How much of the proteome do we see with discovery- based proteomics methods and how much do we need to see? |
| cord-000264-o80duxhs | Is proteomics heading in the wrong direction? |
| cord-000264-o80duxhs | Our genome unveiled Highthroughput mass spectrometric discovery of protein posttranslational modifications Perspectives for mass spectrumetry and functional proteomics Proteomic technology for biomarker profiling in cancer: an update 2D protein electrophoresis: can it be perfected? |
| cord-274101-vm9nh8lc | Membrane fluidity characteristics of human lung cancer Heparan sulfate: anchor for viral intruders? |
| cord-274101-vm9nh8lc | Nisin diffusion in protein films: effects of film type and temperature Influence of amino acid substitutions in the nisin leader peptide on biosynthesis and secretion of nisin by Lactococcus lactis Antiviral activities of lactoferrin Natural products with hypoglycemic, hypotensive, hypocholesterolemic, antiatherosclerotic and antithrombotic activities Expression and purification of antimicrobial peptide buforin IIb in Escherichia coli Lantibiotics: peptides of diverse structure and function Mechanism of interaction of different classes of cationic antimicrobial peptides with planar bilayers and with the cytoplasmic membrane of Escherichia coli Barrel- stave model or toroidal model? |
| cord-284523-lknyehsa | A 2( sPLA 2): friends or foes? |
| cord-284523-lknyehsa | Are they actors in antibacterial and anti- HIV resistance? |
| cord-277716-6gsmkmk5 | How short can you make the pentamer and trimer and still get nanoparticle assembly? |
| cord-277716-6gsmkmk5 | This led us to the question: if the trimeric coiled coil was shortened would nanoparticles still be formed? |
| cord-254404-lrsqrc2u | A comparative review of short and long neuropeptide F signaling in invertebrates: any similarities to vertebrate neuropeptide Y signaling? |
| cord-254404-lrsqrc2u | If the echinoderm NPY- like peptides are not orthologs of NPY/ NPF- type neuropeptides, then what are they? |
| cord-287123-ldkuwcc7 | What formyl peptide receptors, if any, are triggered by compound 43 and lipoxin a4? |
| cord-287123-ldkuwcc7 | What makes them special? |
| cord-331633-ix5un6c9 | Part I- Clinical Trials Legislation and Good Manufacturing Practices( GMP) of Nanotherapeutics in the EU Delivery systems for antimicrobial peptides Antimicrobial peptides Antimicrobial peptides: An alternative for innovative medicines? |
| cord-331633-ix5un6c9 | Resistance Is Futile? |
| cord-000128-t74b5j2j | Pre- mRNA splicing and human disease Alternative splicing in disease and therapy Alternative splicing in disease Are splicing mutations the most frequent cause of hereditary disease? |
| cord-000128-t74b5j2j | influence of fixative protocols Is VP22 nuclear homing an artifact? |
| cord-000128-t74b5j2j | siRNA effectively inhibits tumor growth in colon adenocarcinoma Cell- penetrating- peptidemediated siRNA lung delivery Cellular delivery in vivo of siRNA- based therapeutics Targeting the lung using siRNA and antisense based oligonucleotides Delivery of short interfering RNA using endosomolytic cellpenetrating peptides TP10, a delivery vector for decoy oligonucleotides targeting the Myc protein Photo inducible RNA interference using cell permeable protein carrier Cellular siRNA delivery mediated by a cell- permeant RNA- binding protein and photoinduced RNA interference Split genes and RNA splicing The spliceosome: the most complex macromolecular machine in the cell? |
| cord-269756-tid8a464 | At this concentration, what are the changes in the structural dynamics, curvature and hydration of the lipids and in the thermodynamic parameters of the membranes that lead to membrane fusion? |
| cord-269756-tid8a464 | a hairpin Structure and function of membrane fusion peptides Are fusion peptides a good model to study viral cell fusion? |
| cord-295207-0p6x4lwx | Are fusion peptides really"sided"insertional helices? |
| cord-295207-0p6x4lwx | Could an infectious trigger explain the differential maternal response to shared placental pathology of preeclampsia and normotensive intrauterine growth restriction? |
| cord-011184-ohdukhqt | ( Theobroma cacao L.) autolysates Is there a role for α- glucosidase inhibitors in the prevention of type 2 diabetes mellitus? |
| cord-011184-ohdukhqt | Is the oral route possible for peptide and protein drug delivery? |
| cord-011184-ohdukhqt | Somatostatin- like material is present in flowering plants Research progress in structure- activity relationship of bioactive peptides Peptides: new signalling molecules in plants Identification of the bioactive and consensus peptide motif from Momordica charantia insulin receptor- binding protein Peptides as drugs: is there a market? |
| cord-031957-df4luh5v | Rapid and sensitive sequence comparison with FASTP and FASTA Comparative analysis of the quality of a global algorithm and a local algorithm for alignment of two sequences Programming techniques: regular expression search algorithm Profile hidden Markov models Hidden Markov models and their applications in biological sequence analysis What are the ideal properties for functional food peptides with antihypertensive effect? |
| cord-031957-df4luh5v | parvifolia Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do Möbius strips exist in nature? |
| cord-031957-df4luh5v | pore formers or metabolic inhibitors in bacteria? |
| cord-284690-ogu1gmcb | Antimicrobial and host- defense peptides as new anti- infective therapeutic strategies Antimicrobial peptides( AMPs) as drug candidates: a patent review Quality specifications for peptide drugs: a regulatorypharmaceutical approach Antimicrobial peptides stage a comeback Future directions for peptide therapeutics development Rational design of engineered cationic antimicrobial peptides consisting exclusively of arginine and tryptophan, and their activity against multidrug- resistant pathogens Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? |
| cord-284690-ogu1gmcb | Can innate immunity be enhanced to treat microbial infections? |
| cord-262253-3ovqhypt | : Do They Cross the Gut- Blood Barrier? |
| cord-262253-3ovqhypt | The amyloid hypothesis: Let sleeping dogmas lie? |
| cord-262253-3ovqhypt | Why does the Aβ peptide of Alzheimer share structural similarity with antimicrobial peptides? |
| cord-320497-e5pb83mj | An episulfide cation( thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide- based ketone inhibitors Evolutionary divergence of substrate specificity within the chymotrypsin- like serine protease fold Structural basis for the substrate specificity of tobacco etch virus protease Structures of two coronavirus main proteases: implications for substrate binding and antiviral drug design Crystal structure of an inhibitor complex of the 3C proteinase from hepatitis A virus( HAV) and implications for the polyprotein processing in HAV A continuous assay for foot- and- mouth disease virus 3C protease activity Improved methods for building protein models in electron density maps and the location of errors in these maps Version 1.2 of the Crystallography and NMR System Structural analysis of foot- and- mouth disease virus 3C protease: a viable target for antiviral drugs? |
| cord-320497-e5pb83mj | Given the close structural similarity between FMDV and HRV 3C pro in the S1 pocket, why does HRV 3C pro discriminate so strongly against P1-Glu? |
| cord-320497-e5pb83mj | Why is Cys142 strictly conserved in FMDV 3C pro? |
| cord-257494-242k58ll | : How far are we? |
| cord-257494-242k58ll | In light of this scarce resistance mechanisms de novo acquisition, what mechanisms do bacteria naturally develop/ possess against ABPs? |
| cord-257494-242k58ll | Pore formers or metabolic inhibitors in bacteria? |
| cord-257494-242k58ll | Structural relationship between human salivary histatins Zinc and copper bind to unique sites of histatin 5 Is salivary histatin 5 a metallopeptide? |
| cord-316792-89f8g0m8 | Do the potential benefits outweigh the risks? |
| cord-316792-89f8g0m8 | How ow? |
| cord-316792-89f8g0m8 | The emergence of macrocyclic lactone resistance in the canine heartworm, Dirofilaria immitis Multiple drug resistance in the canine hookworm Ancylostoma caninum: an emerging threat? |
| cord-316792-89f8g0m8 | The venom optimization hypothesis revisited Combinatorial peptide libraries in drug design: lessons from venomous cone snails Were arachnids the first to use combinatorial peptide libraries? |
| cord-316792-89f8g0m8 | crawling biochemists with diverse toxin pharmacopeias Entomo- venomics: the evolution, biology and biochemistry of insect venoms Pharmacology and biochemistry of spider venoms Venom composition and strategies in spiders: is everything possible? |
| cord-023209-un2ysc2v | And, is Abeta modifi ed by 1( 2) able to aggregate at low concentrations on a biologically relevant time scale? |
| cord-023209-un2ysc2v | Because these compounds were rationally designed by using the co- crystallized structure of VEGF with the immunoglobulin like fragment 2 of VEGFR-1, we raise the following question: do these antagonists really target the immunoglobulin like domain 2 of VEGFR-1? |
| cord-023209-un2ysc2v | C more or less resistant to denaturation conditions? |
| cord-023209-un2ysc2v | Conformational preferences of investigated systems were obtained on base of ROESY and NOESY experiments and calculations by use of X- PLOR and quantum chemical calculation Is concentration overload or volume overload the best strategy for synthetic peptide purifi cation? |
| cord-023209-un2ysc2v | Peptido2.rotaxanes: can a tetramide macrocycle travel to a station by wrapping up around a helical peptide thread? |
| cord-023209-un2ysc2v | lower the CC of Abeta aggregation into the PC range? |
| cord-289161-d7shmb2o | Are we gatherers or hunters? |
| cord-289161-d7shmb2o | However when one considers the many hundreds( over a thousand?) of antimicrobial peptides characterised in the last twenty years, the lack of any really new therapeutic anti- microbial agents is singularly depressing. |
| cord-289161-d7shmb2o | The hemolytic activity of six arachnid cationic peptides is affected by the phosphatidylcholine- to- sphingomyelin ratio in lipid bilayers Lipid dependence of antimicrobial peptide activity is an unreliable experimental test for different pore models Refined structure of charybdotoxin: common motifs in scorpion toxins and insect defensins Isolation, molecular cloning and functional characterization of a novel beta- toxin from the Venezuelan scorpion, Tityus zulianus Nanostructures as promising tools for delivery of antimicrobial peptides Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? |
| cord-289161-d7shmb2o | The use of venom transcripts, mass spectrometry and bioinformatics tools leads to the question whether this combined approach is now regarded as paradigm of choice for identifying low abundance, and( perhaps?) |
| cord-289161-d7shmb2o | Whilst the field of antimicrobial peptides has developed rapidly over the last two decades, with a plethora of peptides been identified and numerous structural/ functional relationship studies undertaken, one fundamental paradigm still remains e how to develop AMPs into the clinical setting? |
| cord-289161-d7shmb2o | e what approach is to be taken within future years regarding venom compound research? |
| cord-289161-d7shmb2o | more potent, antimicrobial peptides? |
| cord-291534-c6cjxq07 | A potential issue with using defensins as a topical antiviral treatment is that, despite CHDPs( including defensins) being required for in vitro anti- HIV activity of vaginal fluid from healthy women, defensins may also cause immune activation and subsequent loss of CD4? |
| cord-291534-c6cjxq07 | Both down- regulate the co- receptor CXCR4 expression( but not CCR5) on the surface of CD4? |
| cord-291534-c6cjxq07 | Gene structure and developmental expression Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract Neisseria gonorrhoeae- induced human defensins 5 and 6 increase HIV infectivity: role in enhanced transmission Paneth cell defensins: endogenous peptide components of intestinal host defense Mouse neutrophils lack defensins Strain- specific polymorphisms in Paneth cell alpha- defensins of C57BL/6 mice and evidence of vestigial myeloid alpha- defensin pseudogenes Antibacterial activity and specificity of the six human{ alpha}-defensins Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? |
| cord-291534-c6cjxq07 | In addition b- defensins are described as having a range of immunomodulatory properties, including chemotaxis of CD4? |
| cord-291534-c6cjxq07 | Initial studies on retrocyclins found no direct inactivation of HIV-1, but demonstrated strong inhibition of proviral DNA formation and protection of primary human CD4? |
| cord-291534-c6cjxq07 | LL-37 has been shown to inhibit the replication of a range of HIV-1 isolates in primary CD4? |
| cord-291534-c6cjxq07 | Of these, RC100 was found to inhibit primary CD4? |
| cord-291534-c6cjxq07 | a- Defensins have been demonstrated to directly inactivate HIV-1, with the observation of reduced cytopathogenicity in a CD4? |
| cord-291534-c6cjxq07 | dendritic and T cell CCR6 Human beta- defensin-3 promotes wound healing in infected diabetic wounds beta- Defensins: multifunctional modulators of infection, inflammation and more? |
| cord-315115-f61xcnuw | ( 2) When was the first member of each amphibian peptide family reported? |
| cord-315115-f61xcnuw | ( 3) How will the averaged amino acid signature of amphibian peptides alter from continent to continent? |
| cord-315115-f61xcnuw | : A lesson from amphibian skin- derived esculentin-1 peptides Knowledge- based computational methods for identifying or designing novel, non- homologous antimicrobial peptides Computer- aided Discovery of Peptides that Specifically Attack Bacterial Computer- Aided Design of Antimicrobial Peptides: Are We Generating Effective Drug Candidates? |
| cord-315115-f61xcnuw | Antimalarial activities of dermaseptin S4 derivatives Antimicrobial peptides: A new class of antimalarial drugs? |
| cord-315115-f61xcnuw | If not, which functional role requires the stability of these peptides in innate immune systems? |
| cord-315115-f61xcnuw | Is this property necessary for antimicrobial activity? |
| cord-315115-f61xcnuw | It will address the following questions:( 1) how many AMPs were discovered per year since the publication of magainins? |
| cord-315115-f61xcnuw | Linking structure to function? |
| cord-315115-f61xcnuw | Then why bother with long peptides? |
| cord-315115-f61xcnuw | With so many peptide families, is there any theme that connects them? |
| cord-001835-0s7ok4uw | 3) Can an exhaustive statistical scan of a large, recent dataset identify new side chain interactions at helix termini? |
| cord-001835-0s7ok4uw | A Promoter or Inhibitor for IAPP aggregation? |
| cord-001835-0s7ok4uw | An empirical framework for binary interactome mapping Estimating the size of the human interactome Coming to peace with protein complexes? |
| cord-001835-0s7ok4uw | Are they essential in carrying out a specific cellular function? |
| cord-001835-0s7ok4uw | But the general effects on traits relevant at atomic/ residue resolutions have been less studied, and one fundamental issue remains unsolved: to what extent are proteins forced into interactions with highly concentrated solutes, and with what direct consequences? |
| cord-001835-0s7ok4uw | Can Bio- functionalities be deciphered from protein sequence information using computational approaches? |
| cord-001835-0s7ok4uw | Can site- directed mutagenesis shed light on the refolding pattern of human glucose 6-phosphate dehydrogenase( G6PD)? |
| cord-001835-0s7ok4uw | Can the structure of a protein( H3.1) depend on the treatment of a solvent medium( explicit vs effective) in a coarse- grained computer simulation? |
| cord-001835-0s7ok4uw | Do they play a regulatory role in controlling the on and off of a certain cellular process? |
| cord-001835-0s7ok4uw | How did enzymes, the catalysts of many crucial cellular processes, achieve this cold adaptation? |
| cord-001835-0s7ok4uw | In a protein engineering context, do we need to take into account the dynamics in order to maximize the fitness and function of the resulting proteins? |
| cord-001835-0s7ok4uw | Is there evolutionary pressure to conserve dynamics? |
| cord-001835-0s7ok4uw | Is this necessary to retain functionality, as it has been suggested? |
| cord-001835-0s7ok4uw | Protein engineering: what's next? |
| cord-001835-0s7ok4uw | Questions under- investigation includes what are the effects of mutations( e.g. b- and g- synuclein), how does the structure of an isolated ASN chain change in presence of many interacting protein chains, and how do they organize over the multiple length scales? |
| cord-001835-0s7ok4uw | To what extent are helix- terminal motifs that include multiple amino acids likely to represent genuine cooperative interactions between side chains, rather than chance alignments? |
| cord-001835-0s7ok4uw | Which particular helix- terminal loop geometries are favored by each side chain interaction? |