trigram

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trigram	frequency
as well as	539
the presence of	516
in order to	427
of the peptide	393
the development of	336
one of the	312
based on the	305
the use of	289
due to the	254
the formation of	245
in the presence	238
the synthesis of	232
structure of the	212
it has been	176
a variety of	175
in this study	174
of the protein	174
the role of	164
of the peptides	162
the effect of	161
a number of	160
found to be	158
herpes simplex virus	155
been shown to	153
amino acid residues	152
the design of	148
the mechanism of	146
h h h	145
the treatment of	145
in addition to	140
the structure of	139
the number of	136
analysis of the	135
of these peptides	133
can be used	131
involved in the	128
the identification of	126
the activity of	123
was found to	120
has been shown	119
a series of	117
derived from the	117
the case of	116
the surface of	116
human immunodeficiency virus	114
and in vivo	113
activity of the	113
of the most	113
on the other	110
of antimicrobial peptides	107
the ability to	107
mechanism of action	107
with respect to	107
in vitro and	107
the production of	107
in the case	106
formyl peptide receptor	106
and characterization of	105
peptides and proteins	104
the amino acid	104
the other hand	103
shown to be	102
the absence of	102
well as the	101
to determine the	100
in the present	100
of amino acid	100
the importance of	99
vitro and in	99
for the development	98
as a result	98
severe acute respiratory	97
the effects of	97
according to the	96
for the treatment	96
crystal structure of	96
are able to	95
acute respiratory syndrome	95
to be a	95
to investigate the	95
role in the	94
was used to	94
the interaction of	94
peptides derived from	94
of the human	93
of the two	92
have shown that	92
the active site	92
there is a	91
that can be	91
in this work	91
the ability of	91
phase peptide synthesis	91
the aim of	90
host defence peptides	89
amino acid sequence	89
is one of	89
part of the	88
in which the	88
properties of the	88
the binding of	88
such as the	88
of the membrane	88
an important role	87
of amino acids	87
cov cl pro	86
on the surface	86
is based on	85
were found to	84
in the absence	83
the present study	83
responsible for the	83
corresponding to the	82
be used to	81
binding to the	81
important role in	81
a range of	80
have been identified	78
changes in the	77
of a novel	77
of a peptide	76
a set of	76
of action of	76
and in the	76
to study the	75
to that of	75
region of the	75
wide range of	74
at the n	74
showed that the	74
the expression of	74
peptides have been	74
the results of	74
interaction with the	74
simplex virus type	74
present in the	73
used as a	73
was carried out	72
of the c	72
peptides in the	72
has also been	72
in contrast to	72
that of the	72
most of the	71
have been used	71
of the n	71
can also be	71
amino acids in	71
of peptides and	70
the interaction between	70
in the development	70
sequence of the	70
surface of the	70
in response to	70
were able to	69
due to its	69
at the c	69
compared to the	69
have been developed	69
used for the	68
the discovery of	68
the detection of	68
the sequence of	68
the application of	67
used in the	67
biological activity of	67
a wide range	67
was supported by	67
of a protein	67
a combination of	67
in the peptide	67
immunodeficiency virus type	66
have also been	66
will be presented	66
understanding of the	66
are involved in	66
amino acids and	65
the analysis of	65
peptides from the	65
residues in the	65
in terms of	65
is able to	64
nature of the	64
of the target	64
presence of the	64
amino acid sequences	64
an increase in	64
to improve the	63
to interact with	63
of the enzyme	63
suggest that the	63
we found that	63
depending on the	62
the cell membrane	62
in the p	62
due to their	62
peptide derived from	62
was shown to	62
role of the	62
the activation of	62
be used for	61
characterization of the	61
at room temperature	61
related to the	61
the lack of	60
to be the	60
the basis of	60
effect on the	60
and can be	60
isolated from the	60
is the most	60
of this study	60
in combination with	59
because of the	59
domain of the	59
for the synthesis	59
by means of	59
antimicrobial activity of	59
these peptides are	59
the release of	58
the plasma membrane	58
the venom of	58
the nature of	58
in recent years	58
been used to	58
from the venom	57
effect of the	57
for the design	57
some of the	57
characterization of a	57
to identify the	57
the addition of	57
found in the	56
in the same	56
has been used	56
associated with the	56
were used to	56
solid phase peptide	56
the antimicrobial peptide	56
the regulation of	56
based on a	56
their ability to	56
the majority of	56
presence of a	55
the study of	55
found that the	55
the fact that	55
revealed that the	55
of the sars	55
appears to be	55
led to the	54
been found to	54
this work was	54
large number of	54
to evaluate the	54
the concentration of	54
formation of a	54
show that the	53
molecular dynamics simulations	53
have been shown	53
the spike protein	53
in the range	52
phage display technology	52
in the brain	52
as shown in	52
stability of the	52
demonstrated that the	52
interact with the	52
to increase the	52
the incorporation of	52
the function of	52
the peptides were	51
the introduction of	51
will be discussed	51
to understand the	51
a role in	51
are known to	51
the secondary structure	51
of the viral	51
at the same	51
peptides can be	51
binding of the	50
of a new	50
we have developed	50
the generation of	50
be used as	50
the crystal structure	50
the amount of	50
a large number	50
mode of action	50
the biological activity	49
length of the	49
function of the	49
the rate of	49
between the two	49
structure and function	49
was able to	48
aim of this	48
in the cell	48
of the three	48
which is a	48
to assess the	48
formation of the	48
of the amino	48
a result of	48
to inhibit the	48
central nervous system	48
of the virus	48
fmdv c pro	48
development of new	47
in the literature	47
which can be	47
of herpes simplex	47
the potential of	47
on the basis	47
to form a	47
the p position	47
structures of the	47
were synthesized by	47
we report the	47
interactions between the	47
development of a	47
increase in the	47
were carried out	46
it was found	46
the side chain	46
supported by the	46
shown that the	46
some of these	46
the fi rst	46
play an important	46
study was to	46
each of the	46
the stability of	46
this study was	46
synthesis of the	46
proteins and peptides	46
to bind to	46
be involved in	45
the inhibition of	45
of the cell	45
the preparation of	45
the delivery of	45
has been demonstrated	45
mechanisms of action	45
results suggest that	45
and it is	44
structural and functional	44
to the peptide	44
peptides and their	44
the most potent	44
is involved in	44
a mixture of	44
the context of	44
the possibility of	44
has not been	44
the most important	44
the field of	44
the structure and	44
the influence of	44
amino acid composition	44
respect to the	44
is required for	44
for min at	43
member of the	43
in the treatment	43
activation of the	43
venom of the	43
it is possible	43
in the field	43
regions of the	43
antimicrobial peptides from	43
have been reported	43
similar to that	43
the in vivo	43
was used as	43
of the binding	43
the most common	43
be used in	43
lead to the	42
suggested that the	42
of the antimicrobial	42
the process of	42
focused on the	42
leading to the	42
is an important	42
conformation of the	42
we show that	42
the results obtained	42
than that of	42
there is no	42
is responsible for	42
the range of	42
interaction of the	42
of proteins and	42
the binding site	42
the level of	42
of the bilayer	41
synthesis of a	41
it can be	41
the antimicrobial activity	41
consistent with the	41
known to be	41
p and p	41
identification of a	41
as a model	41
the action of	41
in a mouse	41
change in the	41
work was supported	41
as compared to	41
results show that	41
active site of	40
differences in the	40
indicate that the	40
was found that	40
side of the	40
for h at	40
dependent on the	40
the prediction of	40
in patients with	40
size of the	40
tandem mass spectrometry	40
has been developed	40
to predict the	40
secondary structure of	40
shown in figure	40
the growth of	40
has been found	39
it is a	39
effects of the	39
aichi h n	39
of the complex	39
located in the	39
to be used	39
attached to the	39
studies of the	39
is composed of	39
it is not	39
the present work	39
to the formation	39
of the lipid	39
the peptide and	39
in this context	39
of the proteins	38
terminus of the	38
as a consequence	38
it is also	38
mechanism of the	38
observed in the	38
the characterization of	38
an antimicrobial peptide	38
has been proposed	38
in escherichia coli	38
the in vitro	38
this study we	38
have been found	38
we investigated the	38
bind to the	38
antimicrobial activity against	38
of this peptide	38
the interaction with	38
and function of	38
added to the	38
respiratory syndrome coronavirus	38
cell penetrating peptides	38
design of a	38
contribute to the	38
end of the	38
antimicrobial peptides in	37
be able to	37
able to inhibit	37
the peptide is	37
is known to	37
to be more	37
viral fusion proteins	37
use of the	37
seems to be	37
the innate immune	37
of the s	37
is essential for	37
proved to be	37
that the peptide	37
in the membrane	37
the synthesis and	37
amino acids are	37
could be used	37
structure of a	37
are based on	36
addition to the	36
have been described	36
new class of	36
it was shown	36
insight into the	36
of the major	36
of the structure	36
peptide and protein	36
interaction between the	36
to elucidate the	36
here we present	36
depends on the	36
been identified in	36
is due to	36
the size of	36
of the hiv	36
the amino acids	36
for the first	36
this is the	36
the lipid bilayer	36
of the innate	36
antiviral activity of	36
well as in	36
for the detection	36
followed by a	36
results indicate that	36
and biological activity	36
were used as	35
to the n	35
all of the	35
identification of the	35
in the apd	35
is used to	35
we have shown	35
leads to the	35
is a key	35
insights into the	35
a and b	35
core of the	35
members of the	35
the host cell	35
by using the	35
the conformation of	35
was added to	35
in complex with	35
been demonstrated to	35
by mass spectrometry	35
that have been	35
peptides were synthesized	35
rational design of	35
in aqueous solution	35
these peptides were	35
information on the	35
the determination of	35
key role in	35
are shown in	35
a total of	35
is important to	35
cellular uptake of	34
is associated with	34
in the context	34
peptide from the	34
antimicrobial peptides and	34
have to be	34
the wild type	34
of peptides with	34
on the structure	34
determination of the	34
a key role	34
we developed a	34
a mouse model	34
ce and cec	34
peptides corresponding to	34
referred to as	34
the immune system	34
also known as	34
for this purpose	34
was determined by	34
the phage display	34
in the design	34
to the presence	34
has been reported	34
the potential to	34
hepatitis c virus	34
due to a	33
likely to be	33
broad range of	33
we present the	33
wide variety of	33
the ct peptide	33
components of the	33
in the last	33
and in vitro	33
it should be	33
the course of	33
of a single	33
the loss of	33
solid phase synthesis	33
a group of	33
of the spike	33
indicated that the	33
its ability to	33
resulted in the	33
a family of	33
different types of	33
the central nervous	33
of the a	33
identified in the	33
of the native	33
need to be	33
studies have shown	32
peptides on the	32
it is important	32
substrate specificity of	32
hydrophobic amino acids	32
applied to the	32
to reduce the	32
form of the	32
orientation of the	32
for binding to	32
we were able	32
the properties of	32
the impact of	32
in some cases	32
the spike glycoprotein	32
one or more	32
have been proposed	32
effects on the	32
obtained from the	32
in the n	32
the first time	32
the viral envelope	32
peptide and the	32
cleavage of the	32
expressed in the	32
component of the	32
that it is	32
study of the	32
of host defence	32
designed and synthesized	32
the combination of	32
the length of	32
the target protein	32
studies on the	32
compared with the	32
comparison of the	31
in the human	31
appear to be	31
plays an important	31
seem to be	31
native chemical ligation	31
amino acid residue	31
results in the	31
of synthetic peptides	31
to play a	31
the v loop	31
a member of	31
a wide variety	31
use of a	31
in the regulation	31
mutations in the	31
the same time	31
activity of a	31
the immune response	31
investigation of the	31
method for the	31
suggesting that the	31
when compared to	31
the construction of	31
the need for	31
caused by the	31
residues of the	31
has been suggested	31
surface plasmon resonance	31
contrast to the	31
is the first	31
play a role	31
shown in fig	31
considered to be	31
importance of the	31
the possibility to	30
the peptide was	30
in comparison to	30
ability of the	30
been widely used	30
the interactions between	30
close to the	30
sequences of the	30
the cell surface	30
characterized by a	30
to be an	30
suggests that the	30
carried out by	30
specificity of the	30
been shown that	30
of biologically active	30
is related to	30
the sequences of	30
a panel of	30
results showed that	30
model of the	30
our understanding of	30
nuclear magnetic resonance	30
based on their	30
features of the	30
interacting with the	30
amino acids with	30
site of the	30
with high affinity	30
of human immunodeficiency	29
were tested for	29
to be involved	29
the peptide sequence	29
belongs to the	29
many of the	29
the assembly of	29
of the substrate	29
with the peptide	29
and amino acid	29
of peptides in	29
were shown to	29
the peptide to	29
acts as a	29
which is the	29
of the interaction	29
be due to	29
a synthetic peptide	29
located at the	29
of the resulting	29
resulted in a	29
in the protein	29
proteins involved in	29
diseases such as	29
is mediated by	29
for in vivo	29
high degree of	29
these results suggest	29
expression of the	29
positive and gram	29
are present in	29
have been widely	29
that has been	29
to develop a	29
interest in the	29
formyl peptide receptors	28
been developed for	28
in case of	28
the distribution of	28
of the present	28
in the formation	28
van der waals	28
in the first	28
assembly of the	28
the purpose of	28
was used for	28
as a potential	28
by the presence	28
for the preparation	28
identifi cation of	28
side chain of	28
de novo design	28
over the past	28
has to be	28
there is an	28
because of their	28
the peptide in	28
laser desorption ionization	28
to the target	28
we have synthesized	28
may lead to	28
is a potent	28
in the past	28
by using a	28
the result of	28
concentration of the	28
we showed that	28
for the identification	28
were prepared by	28
the most promising	28
to the cell	28
of npy npf	27
the specificity of	27
to characterize the	27
modification of the	27
crystal structures of	27
to analyze the	27
development of the	27
the degree of	27
structural characterization of	27
single amino acid	27
interactions with the	27
in a single	27
in the c	27
are responsible for	27
its interaction with	27
to obtain a	27
peptides with the	27
for the delivery	27
a class of	27
we have designed	27
on the peptide	27
the peptides are	27
a broad range	27
the formyl peptide	27
to the development	27
isothermal titration calorimetry	27
the position of	27
has been widely	27
amino acid substitutions	27
in this case	27
be considered as	27
we have recently	27
the involvement of	27
essential for the	27
with the aim	27
a amino acid	27
size exclusion chromatography	27
is that the	26
and has been	26
proteins in the	26
high affi nity	26
was applied to	26
as in the	26
in vivo studies	26
innate immune system	26
position of the	26
in the sequence	26
of the molecular	26
to explore the	26
a decrease in	26
together with the	26
based on this	26
acid residues in	26
by solid phase	26
is expressed in	26
is a major	26
at least two	26
the substrate specificity	26
is believed to	26
similar to those	26
between the peptide	26
the hydrophobic core	26
binding domain of	26
data not shown	26
cationic antimicrobial peptides	26
evaluation of the	26
of severe acute	26
were obtained by	26
we have used	26
on the use	26
proteins such as	26
the cells were	26
this work we	26
the side chains	26
assisted laser desorption	26
a library of	26
the separation of	26
helical coiled coil	26
is important for	26
can be found	26
to the c	26
were synthesized and	26
of the fusion	26
of these proteins	26
it is known	26
of membrane proteins	26
peptides and the	26
has led to	25
in comparison with	25
the location of	25
we describe the	25
composed of a	25
fpr and fpr	25
have not been	25
was shown that	25
indicating that the	25
with a high	25
in a variety	25
the filamentous phage	25
in the cytoplasm	25
antimicrobial activity and	25
is known that	25
results of the	25
the affinity of	25
binding site of	25
a highly conserved	25
peptides of the	25
of the coiled	25
step in the	25
the folding of	25
amino acids were	25
belonging to the	25
are characterized by	25
state of the	25
in the s	25
because of its	25
hla class ii	25
protein data bank	25
at least one	25
regulation of the	25
the mechanisms of	25
is found in	25
along with the	25
in the second	25
can lead to	25
of proteins in	25
a new class	25
of bioactive peptides	25
and that the	25
the site of	25
is present in	25
removal of the	25
derived from a	25
mouse model of	25
peptides such as	25
cells of the	25
for treatment of	25
induced by the	25
in animal models	25
are the most	25
of small molecules	25
formed by the	25
a consequence of	24
of this work	24
it may be	24
can be easily	24
activity against gram	24
peptide in the	24
the peptide backbone	24
specific for the	24
analysis of a	24
an attempt to	24
it is well	24
and identification of	24
resulting in a	24
background and aims	24
we have also	24
thickness of the	24
they can be	24
been proposed to	24
antibacterial activity of	24
by phage display	24
and mass spectrometry	24
some of them	24
better understanding of	24
the evolution of	24
inhibitory activity of	24
activity of these	24
to be effective	24
similar to the	24
basis of the	24
are essential for	24
based on these	24
biologically active peptides	24
synthesis of peptides	24
in vivo and	24
of these compounds	24
development of novel	24
carried out on	24
which has been	24
of the phage	24
these results are	24
the university of	24
chemical synthesis of	24
low molecular weight	24
the peptide array	24
act as a	24
of the main	24
the interactions of	24
out of the	24
peptide inhibitors of	24
interfere with the	24
peptides isolated from	24
hydroxysteroid dehydrogenase type	24
in our laboratory	24
a critical role	24
we propose that	24
which may be	24
there are two	24
for the presence	24
at a concentration	24
the pathogenesis of	24
of the same	24
of this approach	24
majority of the	24
the two peptides	24
determined by the	23
the structural and	23
mediated by the	23
bound to the	23
able to bind	23
activity in the	23
used as the	23
for the production	23
the performance of	23
may be a	23
side chains of	23
to examine the	23
have been investigated	23
the occurrence of	23
critical role in	23
peptide nucleic acids	23
sequence of a	23
we demonstrated that	23
and the peptide	23
shown to have	23
and the other	23
and the c	23
to be highly	23
inhibition of the	23
is supported by	23
shows that the	23
the end of	23
were used for	23
be responsible for	23
proven to be	23
unnatural amino acids	23
design of new	23
light on the	23
in the central	23
of peptides that	23
for use in	23
approved by the	23
exposed to the	23
of the receptor	23
used in this	23
demonstrated to be	23
the advantage of	23
knowledge of the	23
and for the	23
have been synthesized	23
and synthesis of	23
design and synthesis	23
the cell wall	23
and of the	23
the basis for	23
here we report	23
an example of	23
the percentage of	23
acids in the	23
to obtain the	23
from the skin	23
we used the	23
therapeutic potential of	23
is a powerful	23
residues on the	23
transmission electron microscopy	23
is characterized by	23
the design and	23
results in a	22
the contribution of	22
the solid phase	22
to the protein	22
for the peptide	22
were subjected to	22
in the study	22
relies on the	22
in the early	22
to the membrane	22
a high degree	22
view of the	22
has been applied	22
and have been	22
duchenne muscular dystrophy	22
mass spectrometry and	22
is possible to	22
important for the	22
hydrophobic thickness of	22
to those of	22
a concentration of	22
could be a	22
and on the	22
is likely to	22
the changes in	22
of the transmembrane	22
the de novo	22
of antimicrobial peptide	22
phase synthesis of	22
described in the	22
depend on the	22
the structures of	22
functional characterization of	22
of influenza virus	22
expression of a	22
with amino acid	22
b and c	22
information about the	22
the attachment of	22
been developed to	22
contact with the	22
recent advances in	22
dynamic light scattering	22
in this way	22
each amino acid	22
we have previously	22
terminal region of	22
amino acids that	22
at the end	22
by nmr spectroscopy	22
as determined by	22
this peptide is	22
led to a	22
mouth disease virus	22
proteins have been	22
is well known	22
reactive oxygen species	22
into the membrane	22
can be obtained	22
by interacting with	22
be the most	22
were performed in	22
identified as a	22
the existence of	22
a crucial role	22
of the drug	22
broad spectrum of	22
of a given	22
the search for	22
of at least	22
should be noted	22
was confirmed by	22
the results are	22
is represented by	22
the selection of	22
been reported to	22
residue in the	22
antimicrobial peptide ll	22
the negatively charged	21
potent inhibitors of	21
found to have	21
there has been	21
be useful in	21
have been studied	21
in the fusion	21
used to study	21
we present a	21
to enhance the	21
structural analysis of	21
for their ability	21
of patients with	21
fatty acyl chains	21
ps peptide substrates	21
terminal part of	21
is also a	21
to the active	21
were determined by	21
the availability of	21
have the ability	21
to the identification	21
according to their	21
the insertion of	21
in the transmembrane	21
of the sequence	21
to test the	21
in an attempt	21
be useful for	21
of viral proteins	21
may not be	21
that these peptides	21
carried out using	21
at low concentrations	21
protein in the	21
in this review	21
of the synthetic	21
molecular dynamics simulation	21
our results show	21
hepatitis b virus	21
that could be	21
belong to the	21
solution structure of	21
by binding to	21
the linker region	21
that the n	21
peptide corresponding to	21
be noted that	21
is not a	21
npy npf prrp	21
to optimize the	21
and development of	21
was studied by	21
resulting in the	21
phage display libraries	21
acid sequence of	21
the united states	21
been applied to	21
was to investigate	21
is dependent on	21
was performed in	21
been used for	21
of a large	21
growth factor receptor	21
able to induce	21
to cross the	21
included in the	21
cl pro cleavage	21
and analysis of	21
in a number	21
the most active	21
the molecular mechanism	21
of the new	21
is consistent with	21
prediction of the	21
the uptake of	21
peptides with a	21
in the process	21
to the synthesis	21
as an alternative	21
one of these	21
of both the	21
observed for the	21
to the surface	21
antimicrobial peptide from	21
the efficiency of	21
required for the	21
peptides that are	21
the most abundant	21
on the membrane	21
was isolated from	21
this class of	21
in the viral	21
it is the	20
in the future	20
in agreement with	20
with the same	20
of the molecule	20
were used in	20
we have studied	20
characterized by the	20
to the high	20
difference between the	20
natural amino acids	20
used to identify	20
the transmembrane domain	20
the protein is	20
high concentrations of	20
peptide nucleic acid	20
the hydrophobic thickness	20
cancer cell lines	20
has been described	20
for the study	20
were identified in	20
delivery of sirna	20
respiratory syncytial virus	20
disruption of the	20
with regard to	20
which could be	20
no effect on	20
department of chemistry	20
that may be	20
in most cases	20
the synthetic peptide	20
of all the	20
the peptides with	20
be associated with	20
data on the	20
was performed by	20
is similar to	20
the control of	20
peptides in a	20
studies showed that	20
was found in	20
of these two	20
this work is	20
affinity of the	20
molecular basis of	20
the primary structure	20
proteins can be	20
been implicated in	20
results from the	20
in the active	20
and to the	20
tested for their	20
was achieved by	20
c and c	20
of staphylococcus aureus	20
the time of	20
to have a	20
more than one	20
of viral fusion	20
stabilization of the	20
for drug delivery	20
performance liquid chromatography	20
of the hydrophobic	20
for drug discovery	20
of membrane fusion	20
of the reaction	20
thought to be	20
provided by the	20
by the peptide	20
the understanding of	20
acid sequences of	20
of naturally occurring	20
was performed using	20
serum amyloid a	20
i and ii	20
release of the	20
to interfere with	20
as a new	20
in presence of	20
for the interaction	20
the first step	20
with that of	20
novo design of	20
the last decade	20
cells in vitro	20
of the natural	20
aim of the	20
potent and selective	20
the mass spectrum	20
from phage display	20
the type of	20
implicated in the	20
which in turn	20
approach for the	20
the peptide chain	20
because it is	20
was observed in	20
also be used	20
been associated with	20
in the interaction	19
shared tryptic peptides	19
ability to bind	19
were obtained from	19
can be considered	19
of human beta	19
we have investigated	19
amino acid peptide	19
is essential to	19
is expected to	19
amino acids to	19
that the presence	19
believed to be	19
epidermal growth factor	19
context of the	19
in the rat	19
well as their	19
that are able	19
linear and cyclic	19
the head group	19
agonists and antagonists	19
innate immune response	19
and as a	19
of amps in	19
to overcome this	19
we have found	19
a part of	19
mesenchymal stem cells	19
antimicrobial peptides of	19
the potential for	19
the orientation of	19
at high concentrations	19
is known about	19
crucial role in	19
and molecular dynamics	19
the investigation of	19
peptides were found	19
virus type glycoprotein	19
immune response to	19
the hypothesis that	19
phage display library	19
are used in	19
the human genome	19
residues at the	19
consists of two	19
sequence in the	19
ranging from to	19
of phage display	19
interacts with the	19
by addition of	19
any of the	19
well as to	19
in accordance with	19
aim is to	19
the membrane and	19
were added to	19
interactions of the	19
the past years	19
a component of	19
the concept of	19
location of the	19
this is a	19
in the lipid	19
infl uence of	19
order to investigate	19
important roles in	19
are found in	19
the nt peptide	19
in the current	19
in the hydrophobic	19
human cathelicidin ll	19
peptides of interest	19
is the case	19
as a function	19
at the p	19
affi nity for	19
of the immune	19
in the blood	19
have investigated the	19
a role for	19
upon binding to	19
to create a	19
the fusion of	19
a major role	19
of the non	19
in the identification	19
in this paper	19
and it was	19
the positively charged	19
red blood cells	19
yang et al	19
of more than	19
were incubated with	19
response to the	19
for the analysis	19
found to inhibit	19
amino acids of	19
ms ms spectra	19
the i th	19
has been identified	19
antiviral activity against	19
has been recently	19
characteristics of the	19
were identified by	19
inhibitors of the	19
a function of	19
linked to the	19
major role in	19
been carried out	19
be important for	19
the molecular basis	18
such as those	18
analysis showed that	18
serve as a	18
are required to	18
the observation that	18
the goal of	18
of a number	18
expressed in e	18
the emergence of	18
groups of the	18
is necessary to	18
is a highly	18
of a series	18
peptides based on	18
is crucial for	18
analogues of the	18
studies were performed	18
of them are	18
on the cell	18
attributed to the	18
and stability of	18
be found in	18
parallel to the	18
of the catalytic	18
could also be	18
in spite of	18
at the surface	18
is caused by	18
of the first	18
was obtained by	18
to the discovery	18
was reported to	18
the modulation of	18
agreement with the	18
result of the	18
allowed us to	18
reduction of the	18
observed that the	18
to form the	18
carried out to	18
the peptides in	18
cell membrane and	18
cells in the	18
activity in vitro	18
as a template	18
by inhibiting the	18
resulting from the	18
sars fp and	18
indicates that the	18
these results indicate	18
in the synthesis	18
bacteria and fungi	18
the accumulation of	18
in the production	18
the increase of	18
be divided into	18
to act as	18
ability to inhibit	18
action of the	18
to address this	18
the substitution of	18
of peptide and	18
the crystal structures	18
chikv e glycoprotein	18
to be important	18
of the model	18
a new method	18
is used as	18
protein structure and	18
is shown in	18
with the highest	18
is possible that	18
electrostatic interactions between	18
the entry of	18
proteins that are	18
the cellular uptake	18
can be classified	18
and sars ifp	18
the membrane surface	18
purification and characterization	18
so as to	18
in contact with	18
useful in the	18
of the original	18
hydrophobic and hydrophilic	18
in a dose	18
affinity for the	18
crucial for the	18
the results from	18
concentrations of the	18
introduced into the	18
of the active	18
affi nity and	18
binding site on	18
shown to inhibit	18
we examined the	18
we used a	18
the cleavage of	18
conformational changes of	18
new insights into	18
we will present	18
high levels of	18
we conclude that	18
was identified as	18
the relationship between	18
both in vitro	18
in clinical trials	18
this type of	18
higher than the	18
used to predict	18
with an ic	18
quantitative analysis of	18
little is known	18
to generate a	18
the antibacterial activity	18
but it is	18
have demonstrated that	18
amino acid side	18
was based on	18
there are several	18
results indicated that	18
influence of the	18
of peptides was	18
peptide synthesis and	18
the mode of	18
a broad spectrum	18
been suggested that	18
we studied the	18
have been isolated	18
the liquid crystalline	18
been used as	18
been identified as	18
of the ligand	18
peptides to the	18
and functional characterization	18
leads to a	18
many of these	18
approaches have been	18
each of these	18
may also be	18
of enveloped viruses	17
the cleavage site	17
also able to	17
been isolated from	17
of the cellular	17
will be used	17
has recently been	17
of the antibody	17
of innate immunity	17
that all the	17
to reach the	17
in the recent	17
in innate immunity	17
a subset of	17
the fusion peptide	17
the risk of	17
proteins of the	17
to mimic the	17
sides of the	17
in mammalian cells	17
studies revealed that	17
of the mechanism	17
work was to	17
intracellular delivery of	17
peptide with a	17
composition of the	17
is in the	17
the results show	17
this suggests that	17
at the time	17
is necessary for	17
cationic antimicrobial peptide	17
focus on the	17
on solid support	17
the rational design	17
on the virion	17
strategy for the	17
of the scorpion	17
the severe acute	17
of the selected	17
to changes in	17
endothelial growth factor	17
terminal domain of	17
z value of	17
a model of	17
the screening of	17
we observed that	17
of the compounds	17
part of a	17
viral membrane fusion	17
very similar to	17
the viral genome	17
contributes to the	17
higher than that	17
we believe that	17
addition of the	17
vascular endothelial growth	17
tool for the	17
and the most	17
for each of	17
the efficacy of	17
recent studies have	17
activity of human	17
has been studied	17
modifi cation of	17
with the cell	17
have been demonstrated	17
of this protein	17
as described in	17
that are not	17
be applied to	17
cd and nmr	17
in the previous	17
from herpes simplex	17
we find that	17
molecular mechanism of	17
the peptide with	17
amps can be	17
of the helix	17
were performed using	17
for separation of	17
as part of	17
carried out in	17
dynamics of the	17
able to detect	17
resonance energy transfer	17
when compared with	17
the binding affinity	17
coronavirus spike protein	17
even in the	17
a peptide with	17
the activities of	17
widely used in	17
introduction of the	17
can be seen	17
of nucleic acids	17
tools for the	17
applications of the	17
been found in	17
of the residues	17
are thought to	17
of a small	17
of the lipids	17
of the dna	17
a volume of	17
be related to	17
conformational changes in	17
properties of these	17
in this process	17
basis for the	17
the cytoplasmic membrane	17
to overcome the	17
amino acid and	17
group of the	17
of the structural	17
bovine serum albumin	17
can be divided	17
has been observed	17
and mechanisms of	17
m z value	17
methods have been	17
number of peptides	17
design of novel	17
to calculate the	17
on the structural	17
consists of a	17
peptide array membrane	17
used to determine	17
the isolation of	17
by circular dichroism	17
terminal amino acid	17
changes of the	17
those of the	17
of the cells	17
been used in	17
spectra of the	17
the most widely	17
by molecular dynamics	16
in water and	16
dynamics simulations of	16
the elucidation of	16
we designed a	16
of the p	16
in vivo in	16
affected by the	16
of a variety	16
protein of interest	16
prediction of protein	16
designed based on	16
alignment of the	16
are associated with	16
cell penetrating peptide	16
taken into account	16
hydrophobic length of	16
the complexity of	16
to the binding	16
of prostate cancer	16
the human cathelicidin	16
strategies have been	16
inhibitory activity against	16
total number of	16
the recognition of	16
addition of a	16
in the structure	16
these peptides have	16
reported that the	16
not yet been	16
there are many	16
with the membrane	16
yet to be	16
presence of an	16
the kinetics of	16
drug delivery systems	16
the ends of	16
as shown by	16
a recent study	16
proof of concept	16
is a promising	16
the dynamics of	16
a lot of	16
antimicrobial peptide database	16
to compare the	16
was obtained from	16
this approach is	16
was replaced by	16
the skin of	16
in the following	16
a better understanding	16
these two peptides	16
of nucleic acid	16
necessary for the	16
and activation of	16
the last years	16
associated with a	16
over the last	16
data suggest that	16
target for the	16
binding free energy	16
parts of the	16
the s protein	16
portion of the	16
and tested for	16
the group of	16
of the protease	16
mediated delivery of	16
fp and sars	16
was incubated with	16
able to recognize	16
the selectivity of	16
leading to a	16
incorporated into the	16
in cancer cells	16
a peptide derived	16
a model system	16
of these new	16
and dynamics of	16
molecules in the	16
supplemental table s	16
in the pathogenesis	16
innate and adaptive	16
the success of	16
the extent of	16
also in the	16
sites in the	16
on the solid	16
rostock h n	16
face of the	16
identification and characterization	16
zhang et al	16
the increase in	16
the form of	16
the aggregation of	16
as the first	16
h and h	16
the rest of	16
that there are	16
an array of	16
the hydrolysis of	16
it would be	16
to generate the	16
is a very	16
modulation of the	16
purpose of this	16
one of them	16
peptide has been	16
antimicrobial peptides with	16
insertion of the	16
these peptides to	16
play a key	16
the authors declare	16
have been obtained	16
appeared to be	16
profile of the	16
in the sample	16
analysis of peptides	16
adjacent to the	16
are used to	16
in our previous	16
based on our	16
is difficult to	16
distribution of the	16
development of an	16
this study is	16
of this enzyme	16
of the parent	16
have the potential	16
h at room	16
secondary structure and	16
a significant role	16
antimicrobial peptides are	16
present study was	16
of fusion peptides	16
can be applied	16
an immune response	16
the inhibitory activity	16
recognition of the	16
an increase of	16
of protein structure	16
supported by a	16
that they are	16
antifungal activity of	16
the case for	16
strategies for the	16
most of them	16
computational design of	16
to give a	16
the fusion process	16
orders of magnitude	16
an amino acid	16
influenza a virus	16
have developed a	16
the innate immunity	16
for development of	16
synthesis of peptide	16
the aim to	16
fusion of the	16
needs to be	16
of amphibian peptides	16
a powerful tool	16
amino group of	16
in host defense	16
protein kinase c	16
resistant staphylococcus aureus	16
in cell culture	16
of the self	16
were treated with	16
their antimicrobial activity	16
is thought to	16
change of the	16
we decided to	16
assembly of a	15
in this model	15
charged amino acids	15
is critical for	15
and epithelial cells	15
used as an	15
structure and dynamics	15
activities of the	15
performed on a	15
could not be	15
for detection of	15
to be considered	15
for ps peptide	15
islet amyloid polypeptide	15
a new generation	15
it was observed	15
more than of	15
amino acids at	15
to contribute to	15
widely used to	15
potent inhibitor of	15
role of this	15
dimensional structure of	15
in the liquid	15
with an n	15
of the anti	15
lead to a	15
result in a	15
in the form	15
shown in table	15
results of this	15
although it is	15
shed light on	15
new generation of	15
which has a	15
the fi nal	15
not able to	15
of peptides are	15
case of the	15
are required for	15
are expected to	15
to the same	15
a serine protease	15
one or two	15
of synthetic peptide	15
but not in	15
the results showed	15
it is worth	15
were found in	15
of the interactions	15
structural features of	15
of viral peptides	15
amino acid in	15
the specifi c	15
is the only	15
of the linker	15
synthesized by solid	15
activity against bacteria	15
relative to the	15
it is necessary	15
distance between the	15
the thickness of	15
of negatively charged	15
delivery to the	15
as carriers for	15
the choice of	15
a model for	15
to amino acids	15
elucidation of the	15
peptides has been	15
the binding to	15
the free energy	15
positions of the	15
conformational analysis of	15
the total number	15
epithelial cells and	15
of dengue virus	15
the distance between	15
a lipid bilayer	15
that in the	15
by a single	15
the endoplasmic reticulum	15
result of a	15
before and after	15
recognized by the	15
atomic force microscopy	15
a single amino	15
of the corresponding	15
the difference in	15
is regulated by	15
and the results	15
fact that the	15
activity against the	15
as an example	15
isolation and characterization	15
performed on the	15
in vitro studies	15
by the use	15
at least three	15
across the membrane	15
we have been	15
have been successfully	15
to better understand	15
contribution to the	15
in figure a	15
impact on the	15
conjugated to a	15
to develop new	15
most of these	15
of amyloid fibrils	15
detection of the	15
of peptides is	15
of the b	15
report the synthesis	15
a novel peptide	15
can be achieved	15
and a peptide	15
the problem of	15
in vivo efficacy	15
the solid support	15
random peptide libraries	15
we focused on	15
of the sequences	15
the creation of	15
of these molecules	15
to the brain	15
and application of	15
inhibitors of hiv	15
in the binding	15
in vitro activity	15
biological activities of	15
well as a	15
molecular mechanisms of	15
have been made	15
order to improve	15
structural basis of	15
the protein data	15
with the n	15
that this peptide	15
limited number of	15
with severe acute	15
of the latter	15
on the same	15
is sufficient to	15
of action and	15
of the central	15
by measuring the	15
we designed and	15
hydrophobic core of	15
added to each	15
are important for	15
the activity and	15
and structure of	15
of a synthetic	15
were performed with	15
which is an	15
may be used	15
that there is	15
the first to	15
here we describe	15
for the separation	15
all of these	15
of the four	15
and mechanism of	15
the induction of	15
liquid crystalline phase	15
reported to be	15
to confirm the	15
of human diseases	15
on the n	15
for the binding	15
a change in	15
west nile virus	15
of drug resistance	15
share a common	15
the virion surface	15
evidence for the	15
in clinical samples	15
there is also	14
to probe the	14
was evaluated by	14
may be useful	14
in relation to	14
was assessed by	14
advantage of the	14
the focus of	14
to induce the	14
previous studies have	14
antimicrobial activity in	14
gene expression in	14
corresponds to the	14
as an important	14
the degradation of	14
as a scaffold	14
the echinoderm receptors	14
amino acid analysis	14
found in human	14
in previous studies	14
potential of the	14
owing to the	14
produced by the	14
gao et al	14
the infl uence	14
is not yet	14
on the market	14
taking into account	14
based epitope mapping	14
and some of	14
protein structure prediction	14
conjugated to the	14
their mechanism of	14
able to interact	14
are likely to	14
the region of	14
action of these	14
the target cell	14
an alternative to	14
of the study	14
also found to	14
acid in the	14
to the design	14
are considered to	14
a is a	14
in conjunction with	14
proteins in a	14
molecular weight of	14
on the molecular	14
the origin of	14
in vitro in	14
the quality of	14
was the most	14
it is likely	14
stages of the	14
of the recombinant	14
the antiviral activity	14
it was also	14
subunit of the	14
the chemical synthesis	14
have been published	14
the value of	14
consisting of a	14
a new family	14
were synthesized using	14
of peptides on	14
nucleic acid delivery	14
for the formation	14
of the antigen	14
to the lack	14
we tested the	14
this method is	14
in light of	14
is the number	14
that bind to	14
we demonstrate that	14
the most effective	14
the reaction of	14
of the plasma	14
as a therapeutic	14
the therapeutic potential	14
the capability of	14
in the pdb	14
the internalization of	14
obtained with the	14
introduction of a	14
detected in the	14
biological activity and	14
and the number	14
it is believed	14
parameters of the	14
useful for the	14
and it has	14
in the nucleus	14
of the synthesized	14
to control the	14
more potent than	14
viral fusion peptides	14
steric block oligonucleotides	14
trichogin ga iv	14
the proliferation of	14
of the gh	14
have found that	14
desorption ionization time	14
suggested to be	14
as a novel	14
an effi cient	14
of protein folding	14
we have identified	14
on solid phase	14
formation of an	14
this peptide was	14
for all the	14
groups in the	14
the modification of	14
transmembrane ot helices	14
peptide synthesis in	14
that the binding	14
from venom of	14
an in vitro	14
were selected for	14
was subjected to	14
has emerged as	14
in living cells	14
their use in	14
inhibit the growth	14
of the other	14
of the side	14
this can be	14
has shown that	14
insertion into the	14
peptide binding to	14
and its derivatives	14
was monitored by	14
expected to be	14
and the presence	14
sequence and structure	14
of proteins with	14
order to understand	14
order to determine	14
may play a	14
the molecular mechanisms	14
considered as a	14
flight mass spectrometry	14
application in the	14
the outer membrane	14
binding affi nity	14
of our study	14
host defense peptides	14
synthesized by the	14
identification of novel	14
design of peptides	14
and characterized by	14
is used for	14
of the predicted	14
of a high	14
these peptides in	14
of peptides to	14
been suggested to	14
with the help	14
production of a	14
intrinsically disordered proteins	14
only in the	14
highly expressed in	14
the naturally occurring	14
room temperature for	14
work is to	14
peptide isolated from	14
an effort to	14
novel antimicrobial peptide	14
delivery of a	14
the advantages of	14
of shared peptides	14
of which are	14
at sites of	14
ng of viral	14
amino acid with	14
to provide a	14
mechanism by which	14
the reduction of	14
with the lipid	14
combinatorial peptide libraries	14
the conversion of	14
and evaluation of	14
binding sites of	14
cells and the	14
high affinity for	14
the help of	14
on the contrary	14
separation of the	14
a flow rate	14
in the database	14
of proteins that	14
characterization of two	14
the presence and	14
all the peptides	14
compared to other	14
also demonstrated that	14
the development and	14
development of peptide	14
well as its	14
interactions in the	14
the decrease in	14
are in the	14
are the main	14
version of the	14
using the same	14
the coupling of	14
and they are	14
method has been	14
acting as a	14
the composition of	14
of peptides were	14
new family of	14
on the mass	14
by use of	14
cell membranes and	14
well as for	14
have been employed	14
expressed protein ligation	14
in human plasma	14
filamentous phage as	14
supported by grants	14
due to an	14
as a tool	14
polyacrylamide gel electrophoresis	14
the change in	14
ad hvr epb	14
capacity of the	14
important in the	14
of the presence	13
the fusion protein	13
in our group	13
the hydrophobic length	13
been demonstrated that	13
reported in the	13
of reactive oxygen	13
was observed that	13
a novel coronavirus	13
were characterized by	13
balb c mice	13
to design a	13
the genome of	13
of these studies	13
the mixture of	13
that they can	13
flow rate of	13
the peptide bond	13
hydrophobicity of the	13
net charge of	13
involved in a	13
conformational preferences of	13
obtained by the	13
did not show	13
good agreement with	13
of gene expression	13
at neutral ph	13
it was demonstrated	13
of the wild	13
min at room	13
protein interactions in	13
in the host	13
results were obtained	13
closely related to	13
than amino acids	13
were observed in	13
similar results were	13
series of peptides	13
von willebrand factor	13
protein folding and	13
binding properties of	13
the most frequently	13
targeted delivery of	13
is a common	13
of the different	13
host cell membrane	13
fl uorescence spectroscopy	13
these peptides is	13
to address the	13
of the conjugates	13
not only for	13
to each well	13
and showed that	13
forms of the	13
the identifi cation	13
prepared by solid	13
the method is	13
data indicate that	13
such as cell	13
the past decade	13
purifi ed by	13
role played by	13
are orthologs of	13
analysis revealed that	13
to the receptor	13
has been successfully	13
an ic of	13
for most of	13
of the bacterial	13
the propensity of	13
the morphology of	13
for the in	13
plays a role	13
production of the	13
applications in the	13
there are no	13
not only the	13
the peptides to	13
a signifi cant	13
in an effort	13
sites on the	13
the thermal stability	13
wang et al	13
shape of the	13
purity of the	13
tof mass spectrometry	13
critical for the	13
it is interesting	13
been identifi ed	13
primary structure of	13
uptake of the	13
binding of a	13
able to cross	13
is a member	13
into mammalian cells	13
fold increase in	13
play a significant	13
but also to	13
of the disease	13
a basis for	13
and so on	13
well known that	13
from the protein	13
of the short	13
in the clinical	13
both in the	13
the human immunodeficiency	13
result in the	13
the coding sequence	13
study is to	13
for the generation	13
the inclusion of	13
study we have	13
incubated with the	13
value of the	13
binds to the	13
of escherichia coli	13
the peptides on	13
be regarded as	13
in the gel	13
antimicrobial activity is	13
with antimicrobial activity	13
small number of	13
with the protein	13
studies have been	13
of the known	13
in the bilayer	13
is a potential	13
vesicular stomatitis virus	13
a database of	13
with and without	13
of antimicrobial activity	13
as building blocks	13
and led to	13
of each peptide	13
food and drug	13
binding pocket of	13
the strength of	13
in humans and	13
the protein and	13
we report on	13
of peptide arrays	13
using circular dichroism	13
type glycoprotein h	13
of interest as	13
of specifi c	13
the native peptide	13
was performed to	13
this indicates that	13
decrease in the	13
their structure and	13
a high affinity	13
in each sample	13
conflict of interest	13
the tertiary structure	13
and the peptides	13
in the liver	13
isolation of a	13
of the complexes	13
we performed a	13
the gene encoding	13
be classified into	13
to monitor the	13
sequences in the	13
activity and the	13
present in a	13
be present in	13
plays a key	13
our results suggest	13
in this communication	13
of the second	13
the details of	13
structural basis for	13
the molecular level	13
the evaluation of	13
levels of the	13
the peptide substrate	13
proteins from the	13
linked to a	13
rest of the	13
starting point for	13
on the viral	13
is likely that	13
only a few	13
formation of pores	13
can be observed	13
at the interface	13
was analyzed by	13
is determined by	13
the peptide sequences	13
of the isolated	13
may contribute to	13
the solution structure	13
the levels of	13
using this approach	13
cells were incubated	13
mutation in the	13
the core of	13
a novel antimicrobial	13
we synthesized a	13
an alternative approach	13
activity of antimicrobial	13
have focused on	13
of hydrogen bonds	13
have been designed	13
and amino acids	13
shown in the	13
disulfi de bonds	13
developed a novel	13
involved in cell	13
is a well	13
the toxicity of	13
a matter of	13
new type of	13
advantage of this	13
huang et al	13
dimensional structures of	13
the gel phase	13
at the molecular	13
aspects of the	13
are expressed in	13
as described previously	13
isolated from a	13