This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.
| identifier | question |
|---|---|
| cord-002282-ldfa616a | Toward the global elimination of hepatitis B virus transmission Optimization of elastin- like polypeptide fusions for expression and purification of recombinant proteins in plants Plant- based edible vaccine against HBV Oral immunization of human with transgenic lettuce expressing hepatitis B surface antigen The twenty- year story of a plant- based vaccine against Hepatitis B: Stagnation or promising prospects? |
| cord-024149-qnclsjym | success and limitations Shifts in bacterial community structure associated with inputs of low molecular weight carbon compounds to soil Bacterial dehalogenases: biochemistry, genetics and biotechnological applications Towards an ecological classification of soil bacteria Multiresistance and tolerance in microbial biofilms Stabilizing mechanisms in legume- rhizobium mutualism Impact of culture- independent studies on the emerging phylogenetic view of bacterial diversity Bioremediation: techniques for cleaning up a mess Fertiliser contaminants in New Zealand grazed pasture with special reference to cadmium and fluorine: a review Microbial heavy metal resistance When do arbuscular mycorrhizal fungi protect plant roots from pathogens? |
| cord-005205-z6bx0309 | enhances wound response of potato proteinase inhibitor II promoter in transgenic tobacco Regulation of the expression of rbc S and other photosynthetic genes by carbohydrates: a mechanism for the'sink regulation'of photosynthesis? |
| cord-016575-bn15006x | Melaleuca alternifolia( tea tree) oil: a review of antimicrobial and other medicinal properties Cannabis and cancer: reality or pipe dream? |
| cord-018018-2yyv8vuy | In planta protein sialylation through overexpression of the respective mammalian pathway Transient Expression of Mammalian Genes in N. benthamiana to Modulate N- Glycosylation Immunogenicity of a subunit vaccine against Bacillus anthracis A plant- produced protective antigen vaccine confers protection in rabbits against a lethal aerosolized challenge with Bacillus anthracis Ames spores How did international agencies perceive the avian influenza problem? |
| cord-307607-8xn9jtmh | ( Antalya)'da etnobotanik bir çalışma Is a universal influenza virus vaccine possible? |
| cord-017419-yrw4wrxj | A natural sweetener and an important ingredient in Chinese medicine Anti- tumor- promoting activities of afromosin and soyasaponin I isolated from Wisteria brachybotrys Potato glycoalkaloids: true safety or false sense of security? |
| cord-306733-df36w6l7 | What Does Plant- Based Vaccine Technology Offer to the Fight against COVID-19? |
| cord-253997-imwjoecx | where are we and where are we going? |
| cord-356019-k7gs1ohp | Pharming and transgenic plants Down- regulated expression of plant- specific glycoepitopes in alfalfa Plant- specific glycosylation patterns in the context of therapeutic protein production Is the drought over for pharming? |
| cord-310439-z0bxsjug | The control of African cassava mosaic virus disease: Phytosanitation and/or resistance? |
| cord-294945-hcf7gsv8 | a balancing act? |
| cord-258489-pyfc7jde | Cowpea mosaic virus- based systems for the production of antigens and antibodies in plants Is the infiltration- centrifugation technique appropriate for the isolation of apoplastic fluid? |
| cord-348992-8su58m68 | How do I Get Condoms? |
| cord-353454-zq51hpjs | stands Purification, identification and activity of phomodione, a furandione from an endophytic Phoma species Who is in there? |
| cord-330827-gu2mt6zp | -Are we there yet? |
| cord-322926-xlwsj3v2 | Recent progress in the development of plant derived vaccines Viral vectors for the expression of proteins in plants Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp Will plant- made biopharmaceuticals play a role in the fight against COVID-19? |
| cord-354950-kmpbdvof | : where are we? |
| cord-018724-ss8x2g3b | How does the genome structure and lifestyle of a virus affect its population variation? |
| cord-018724-ss8x2g3b | Lifestyles of plant viruses Persistent plant viruses: molecular hitchhikers or epigenetic elements? |
| cord-018724-ss8x2g3b | The remarkable evolutionary history of endornaviruses Plant virus metagenomics: advances in virus discovery Metavir 2: new tools for viral metagnome comparison and assembled virome analysis The role of viruses in biological invasions: friend or foe? |
| cord-323768-r7jbm1et | Pea lectin expressed transgenically in oilseed rape reduces growth rate of pollen beetle larvae Plant- insect interactions: What can we learn from plant lectins? |
| cord-350846-8gxkwi9n | What is Aroma Therapy? |
| cord-350846-8gxkwi9n | evidence based complementary and alternative medicine Alternative, or Integrative Health: What's in a Name? |
| cord-015965-n4sjixg8 | Burkholderia fungorum DBT1 can improve phytoremediation efficiency of polycyclic aromatic hydrocarbons Macroalgal endophytes from the atlantic coast of Canada: a potential source of antibiotic natural products? |
| cord-015965-n4sjixg8 | Functional characterization of endophytic fungal community associated with Oryza sativa L. and Zea mays L Can leaf degrading enzymes provide evidence that endophytic fungi becoming saprobes? |
| cord-015965-n4sjixg8 | PsJN A critical view of current state of phytotechnologies to remediate soils: still a promising tool? |
| cord-333518-67md81fq | , I asked myself, why not convert it into a vegetable garden? |
| cord-333518-67md81fq | What to plant? |
| cord-016425-8yd2bkf1 | In other words, why continue to do the same thing when robots, combinatorial chemistry, and molecular biology have arrived on the scene? |
| cord-016425-8yd2bkf1 | Where are the undescribed fungi? |
| cord-016425-8yd2bkf1 | can ecology provide new leads in the search for novel bioactive chemicals from rainforests? |
| cord-268149-narre5e7 | , what are the links? |
| cord-268149-narre5e7 | Do pharmaceuticals displace local knowledge and use of medicinal plants? |
| cord-031957-df4luh5v | Rapid and sensitive sequence comparison with FASTP and FASTA Comparative analysis of the quality of a global algorithm and a local algorithm for alignment of two sequences Programming techniques: regular expression search algorithm Profile hidden Markov models Hidden Markov models and their applications in biological sequence analysis What are the ideal properties for functional food peptides with antihypertensive effect? |
| cord-031957-df4luh5v | parvifolia Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do Möbius strips exist in nature? |
| cord-031957-df4luh5v | pore formers or metabolic inhibitors in bacteria? |
| cord-348812-lufg9w7n | An increase in selenium intake improves immune function and poliovirus handling in adults with marginal selenium status Enrichment of cereal grains with zinc: agronomic or genetic biofortification? |
| cord-348812-lufg9w7n | Can selenium deficiency in Malawi be alleviated through consumption of agro- biofortified maize flour? |
| cord-348812-lufg9w7n | In: Alloway BJ( ed) Heavy metals in soils: trace elements and metalloids in soils and their bioavailability New SARS- like virus in China triggers alarm Selenium in global food systems Selenium analysis and speciation in dietary supplements based on next- generation selenium ingredients Butler Selenium concentration in wheat( Triticum aestivum) grain as influenced by method, rate, and timing of sodium selenate application Biofortification( Se): Does it increase the content of phenolic compounds in virgin olive oil( VOO)? |
| cord-322100-zkuj22oc | CD3? |
| cord-322100-zkuj22oc | CD4? |
| cord-322100-zkuj22oc | Distal mucosal sites contained significantly higher( p\ 0.001) levels of antigen- specific IgA in CpG ODN? |
| cord-322100-zkuj22oc | The humanized mice were immunized by gavage with different amounts of powdered tobacco leaves, and Foxp3? |
| cord-032371-qwqf3rlf | ( Acari: Tetranychidae) induz defesa direta em morangueiro? |
| cord-032371-qwqf3rlf | However, regarding our main research question( how does barley react to the double infestation?) |
| cord-032371-qwqf3rlf | The interface between wheat and the wheat curl mite, Aceria tosichella, the primary vector of globally important viral diseases How to define obligatory anaerobiosis? |
| cord-032371-qwqf3rlf | Verlag Chemie Oxidative stress in pea seedling leaves in response to Acyrthosiphon pisum infestation Is a blue- red light a good elicitor of phenolic compounds in the family Droseraceae? |
| cord-329881-9vnz5zzg | However, before vaccination was discovered, how did people deal with the illness? |
| cord-329881-9vnz5zzg | Redeploying plant defences Investigations on plant antibiotics; studies on allicin, the antibacterial principle of Allium sativum( garlic) What does plant- based vaccine technology offer to the fight against COVID-19? |
| cord-329881-9vnz5zzg | What does welfare economics say? |
| cord-021013-xvc791wx | But what is the situation after herbivory? |
| cord-021013-xvc791wx | How do plants defend themselves against microorganisms( including bacteria, fungi, and viruses), herbivores, and plants? |
| cord-021013-xvc791wx | How is this achieved? |
| cord-021013-xvc791wx | Since Na'is already limited in plant food( an antiherbivore device?), long- term exposure to diuretic compounds would reduce the fitness of an herbivore substantially. |
| cord-021013-xvc791wx | What then is their evolutionary solution? |
| cord-018647-bveks6t1 | Are the biochemical reaction products electroactive? |
| cord-018647-bveks6t1 | Is one of the substrates or cofactors electrically active? |
| cord-018647-bveks6t1 | The main considerations are: Does the enzyme contain active redox groups? |
| cord-018647-bveks6t1 | What is the final application of NBSs? |
| cord-018647-bveks6t1 | What is the speed and response time? |
| cord-024652-4i6kktl0 | ( Theobroma cacao L.) Effect of salicylic acid and structurally related compounds in the accumulation of phytoalexins in cotyledons of common bean Phenylphenalenone phytoalexins, will they be a new type of fungicide? |
| cord-024652-4i6kktl0 | -France Induce systemic resistance and promotion of plant growth by Bacillus spp Antifungal activity of pisiferic acid derivatives against the rice blast fungus Functional moiety for the antifungal activity of phytocassane E, a diterpene phytoalexin from rice Phytoalexin induction in the sapwood of plants of the Maloideae( Rosaceae): biphenyls or dibenzofurans Structural and functional characterization of gene clusters directing non- ribosomal synthesis of bioactive lipopeptides in Bacillus amyloliquefaciens strain FZB42 Evaluation of essential oils and their components for broad- spectrum antifungal activity and control of late leaf spot and crown rot diseases in peanut Bryophytes, a potent source of drugs for tomorrow's medicine? |
| cord-024652-4i6kktl0 | The biocontrol effect of mycorrhization on soil borne fungal pathogens and the autoregulation of the AM symbiosis: one mechanism, two effects? |
| cord-024652-4i6kktl0 | The endogenous elicitor, a fragment of a plant cell wall polysaccharide that elicits phytoalexin accumulation in soybeans Tit for tat? |
| cord-024652-4i6kktl0 | What is the significance of the arbuscular mycorrhizal colonisation of many economically important crop plants? |
| cord-288673-ku3tmjd3 | 3C- like protease inhibitors Regulation of bacterial protease activity Proteins with antifungal properties and other medicinal applications from plants and mushrooms Adaptation of Helicoverpa armigera( Lepidoptera: Noctuidae) to a proteinase inhibitor expressed in transgenic tobacco Novel inhibitor for prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis and details of substrate- recognition mechanism Major surface protease of trypanosomatids: one size fits all? |
| cord-288673-ku3tmjd3 | are new control methods required? |
| cord-288673-ku3tmjd3 | cathepsin B An epoxysuccinic acid derivative(loxistatin)-induced hepatic injury in rats and hamsters Affinity chromatography: principles and methods Computational perspectives into plasmepsins structure- function relationship: implications to inhibitors design IA3, an aspartic proteinase inhibitor from Saccharomyces cerevisiae, is intrinsically unstructured in solution Host cathepsin D response to tumor in the normal and pepstatin- treated mouse Isolation and characterization of E-64, a new thiol protease inhibitor Protein proteinase inhibitor genes in combat against insects, pests, and pathogens: natural and engineered phytoprotection Protease inhibitors: a panacea? |
| cord-288673-ku3tmjd3 | thuringiensis( Bt) transgenic crop: an environment friendly insect- pest management strategy Virulence strategies of plant pathogenic bacteria Understanding the mechanism of action of the exfoliative toxins of Staphylococcus aureus Antiprotease therapy in cancer: hot or not? |
| cord-346053-mk1mzc5z | How can we make sense of the processes that have led to the wide variety of pathogenicity factors in plant pathogens and that continue to drive the evolution of pathogens? |
| cord-346053-mk1mzc5z | How do pathogens, whether they parasitize plants or animals, acquire virulence to new hosts and resistance to the arms we deploy to control disease? |
| cord-346053-mk1mzc5z | The ABC transporter BcatrB affects the sensitivity of Botrytis cinerea to the phytoalexin resveratol and the fungicide fenpiclonil Pathogenicity genes of phytopathogenic fungi Fungal LysM effectors: extinguishers of host immunity? |
| cord-346053-mk1mzc5z | The importance of fungal pectinolytic enzymes in plant invasion, host adaptability and symptom type Pathogenic fungi: leading or led by ambient pH? |
| cord-346053-mk1mzc5z | gypsophilae and betae, recently evolved pathogens? |
| cord-340497-8l3gw6sk | How energy innovation in indoor vertical farming can improve food security, sustainability, and food safety? |
| cord-340497-8l3gw6sk | Why do we seem to have so many outbreaks concerning food production these days? |
| cord-340497-8l3gw6sk | Will consumers find vertically farmed produce"out of reach"? |
| cord-340497-8l3gw6sk | capitata) Effects of different spectral lights on Oncidium PLBs induction, proliferation, and plant regeneration Global food demand, productivity growth, and the scarcity of land and water resources: a spatially explicit mathematical programming approach Hydroponics: are we moving towards that direction only because of the environment? |
| cord-016293-pyb00pt5 | : Is There Ample Evidence? |
| cord-016293-pyb00pt5 | According to anecdotal evidence when visiting his namesake centre, Sanger asked:"What does this machine do then?""Dideoxy sequencing"came the reply, to which Fred retorted:"Have n't they come up with anything better yet?" |
| cord-016293-pyb00pt5 | According to anecdotal evidence when visiting his namesake centre, Sanger asked:"What does this machine do then?""Dideoxy sequencing"came the reply, to which Fred retorted:"Have n't they come up with anything better yet?" |
| cord-016293-pyb00pt5 | Issues of justice and resource allocation also have been raised: In a time of strain on our health care system, can we afford such expensive therapy? |
| cord-016293-pyb00pt5 | That finding led plant pathologist Roger Beachy, then at Washington University in Saint Louis, to wonder exactly how such"cross- protection"worked-did part of the virus prompt it? |
| cord-016293-pyb00pt5 | When Steve Fodor was asked in 2003"How do you really take the Human genome sequence and transform it into knowledge?" |
| cord-016293-pyb00pt5 | Who should receive gene therapy? |
| cord-255018-dhkz23co | El uso de plantas silvestres comestibles en una población suburbana del noroeste de la Patagonia Traditional knowledge of edible wild native and exotic plants in the context of cultural change in human populations of arid Patagonai Ethnobiology and research on global environmental change: what distinctive contribution can we make? |
| cord-255018-dhkz23co | How many local foods are involved? |
| cord-255018-dhkz23co | Intenational Life Sciences Instiute Functional foods or food medicines? |
| cord-255018-dhkz23co | Our main questions were: Which native and exotic plants from Patagonia constitute PEFF? |
| cord-255018-dhkz23co | What proportion is used as functional food? |
| cord-255018-dhkz23co | Which species are currently in use? |
| cord-255018-dhkz23co | cancer An ethnobotanical perspective on traditional fermented plant foods and beverages in Eastern Europe Food or medicine? |
| cord-324335-eoabmyg7 | ( Homoptera: Diaspididae) in mango orchards in Hevel Habsor( Israel) Trends in antimicrobial food packaging systems: emitting sachets and absorbent pads Active food packaging technologies Use of natural antimicrobials to increase antibiotic susceptibility of drug resistant bacteria Glutathione biosynthesis and metabolism in Plasmodium falciparum Traditional herbal remedies and dietary spices from Cameroon as novel sources of larvicides against filariasis mosquitoes? |
| cord-324335-eoabmyg7 | Antibacterial activity of karanj( Pongamia pinnata) and neem( Azadirachta indica) seed oil: a preliminary report Of Malaria, metabolism and membrane transport Old ingredients for a new recipe? |
| cord-324335-eoabmyg7 | Further research is essentially the rational collection of most of the arguments previously considered, as evident in the title:"Green- synthesised nanoparticles from Melia azedarach seeds and the cyclopoid crustacean Cyclops vernalis: an eco- friendly route to control the malaria vector Anopheles stephensi?" |
| cord-324335-eoabmyg7 | How many times did you read about the discovery of a definitive cure to cancer? |
| cord-324335-eoabmyg7 | India Review of antimicrobial food packaging Evaluation of larvicidal activity of medicinal plant extracts against three mosquito vectors Has the Earth's sixth mass extinction already arrived? |
| cord-324335-eoabmyg7 | Lessons from long- term trends in crop production Neonicotinoid- coated Zea mays seeds indirectly affect honeybee performance and pathogen susceptibility in field trials Honey bee survival and pathogen prevalence: from the perspective of landscape and exposure to pesticides Green- synthesised nanoparticles from Melia azedarach seeds and the cyclopoid crustacean Cyclops vernalis: an eco- friendly route to control the malaria vector Anopheles stephensi? |
| cord-324335-eoabmyg7 | Or about the already obtained solution to any physiological problem using staminal cells? |
| cord-324335-eoabmyg7 | Synergy between two calcium channel blockers, verapamil and fantofarone( SR33557), in reversing chloroquine resistance in Plasmodium falciparum Active and intelligent packaging: an introduction How much does agriculture depend on pollinators? |
| cord-324335-eoabmyg7 | neem cake compounds deter oviposition of the arbovirus vector Aedes albopictus( Diptera: Culicidae) in the field Neem( Azadirachta indica): towards the ideal insecticide? |
| cord-014462-11ggaqf1 | Both ATP and GTP were utilized as phosporyl donors and Mn 2? |
| cord-014462-11ggaqf1 | Cut off was calculated as Mean negative control? |
| cord-014462-11ggaqf1 | FMDV P1- 3CD''O''vaccine gene constructs in pCDNA3.1? entrapped by the nanoparticles was prepared by using different molarity of calcium chloride and disodium hydrogen orthophosphate. |
| cord-014462-11ggaqf1 | Helicase activity of NSs was absolutely dependent on ATP and Mg 2? |
| cord-014462-11ggaqf1 | How do Indian journals perform in Maintaining quality? |
| cord-014462-11ggaqf1 | How do motivate the scientists to improve their scientific output? |
| cord-014462-11ggaqf1 | How to motivate the scientists to improve their scientific output? |
| cord-014462-11ggaqf1 | In this regard, rNSs is a unique enzyme which does not have the canonical helicase motifs but can catalyze dsDNA/ dsRNA unwinding in an ATP and Mg 2? |
| cord-014462-11ggaqf1 | Should we compare the growth of Indian science with other developed countries? |
| cord-014462-11ggaqf1 | What ails Indian Science? |
| cord-014462-11ggaqf1 | What criteria should be adopted to judge the quality and standard of scientific research? |
| cord-268590-3e1tb64o | ( b) how many were ignored( i.e., simply no answer)? |
| cord-268590-3e1tb64o | ( c) how many were accepted, but materials are not yet acquired by your Center? |
| cord-268590-3e1tb64o | ( d) how many were accepted and the materials have actually been acquired by your Center? |
| cord-268590-3e1tb64o | ( for materials in in situ and ex situ conditions) Answer Choices 0 1- 3 4- 6 7- 9 other( please indicate number) Answer Choices( a) how many were explicitly rejected? |
| cord-268590-3e1tb64o | Are you concerned that unresolved international negotiations concerning digital genomic sequence information( DSI), and/or the suspension of negotiations to enhance the Plant Treaty's multilateral system of access and benefit- sharing, could, in the future, have a negative impact on the following: CGIAR Centers'genebanks ability to access to PGRFA to include in international collections? |
| cord-268590-3e1tb64o | Are you sometimes asked for PGRFA that you do not have? |
| cord-268590-3e1tb64o | CGIAR Centers'ability to access, generate, use and share digital genomic sequence information( DSI)? |
| cord-268590-3e1tb64o | Centers'management of their Article 15 collections( including distributing PGRFA and related information)? |
| cord-268590-3e1tb64o | How many requests for PGRFA to include in your collection(s) has your genebank made to organizations outside the CGIAR in the last 5 years? |
| cord-268590-3e1tb64o | The FIGS( focused identification of germplasm strategy) approach identifies traits related to drought adaptation in Vicia faba genetic resources Opinions and Advice of the Ad Hoc Technical Advisory Committee on the Multilateral System and the Standard Material Transfer Agreement Are the old International Board for Plant Genetic Resources( IBPGR) base collections available through the Plant Treaty's multilateral system of access and benefit sharing? |
| cord-268590-3e1tb64o | Was there a difference in the kinds of responses you received depending on the types of organizations to whom you addressed your request? |
| cord-268590-3e1tb64o | Was there a difference in the kinds of responses you received depending on whether you were seeking to acquire material from in situ conditions( therefore involving new collecting missions) or materials that were already in ex situ collections? |
| cord-268590-3e1tb64o | Which of the following factors have affected the your genebanks'overall rate of acquisition of PGRFA from sources outside the CGIAR? |
| cord-268590-3e1tb64o | Willingness of some organizations to enter into partnership with CGIAR Centers? |
| cord-268590-3e1tb64o | Would you have preferred to make more requests to acquire more PGRFA over the last 5 years? |
| cord-022889-lv6fy6e6 | -Are plant ncRNAs more stable than animal( mammalian) ncRNAs? |
| cord-022889-lv6fy6e6 | -Do changes in RNAse activity, due to pathologies or human polymorphisms, influence dietary exposure? |
| cord-022889-lv6fy6e6 | -Do exogenous ncRNAs( naked RNAs) resist the conditions of the gastrointestinal tract environment? |
| cord-022889-lv6fy6e6 | -How does exogenous RNAs uptake in mammalian cells occur? |
| cord-022889-lv6fy6e6 | -What are the biological barriers for the exogenous RNAs after absorption and entering into the mammalian circulatory system? |
| cord-022889-lv6fy6e6 | -What are the biological barriers to consumed RNAs? |
| cord-022889-lv6fy6e6 | -What are the main differences between mammalian and plant ncRNAs? |
| cord-022889-lv6fy6e6 | -What are the specific tissue barriers to exogenous ncRNA function? |
| cord-022889-lv6fy6e6 | -What is known about the half- life of ncRNAs? |
| cord-022889-lv6fy6e6 | -What is known about the movement of plant ncRNAs? |
| cord-022889-lv6fy6e6 | -What is the cellular fate of exogenous ncRNAs once inside the cell? |
| cord-022889-lv6fy6e6 | -What is the function of plant ncRNAs? |
| cord-022889-lv6fy6e6 | -What routes of administration have been used for RNA- based therapeutics? |
| cord-022889-lv6fy6e6 | -What type of ncRNAs are described in plants? |
| cord-022889-lv6fy6e6 | -Which human or animal cells( i.e. lymphocytes, macrophages, myeloid) are possibly involved in immune responses mediated by plant- derived ncRNAs? |
| cord-022889-lv6fy6e6 | -Which innate immunity mediators( i.e. chemokines, cytokines) have been identified in humans and animals as associated to effects of plant- derived ncRNAs? |
| cord-022889-lv6fy6e6 | -Why is it relevant to consider ncRNA stability outside the organism of origin( plant)? |
| cord-022889-lv6fy6e6 | Because this specific topic is especially salient to future understanding of the possible food/ feed risk assessment of ncRNAs- based GM plants, all the identified studies were further evaluated by title and abstract and their relevance to answering the identified key questions: does the literature describe the effect of exogenous plant- origin ncRNAs when consumed orally? |
| cord-022889-lv6fy6e6 | In silico identification of plant miRNAs in mammalian breast milk exosomes-- a small step forward? |
| cord-022889-lv6fy6e6 | In silico identification of plant miRNAs in mammalian breast milk exosomes-- a small step forward? |
| cord-022889-lv6fy6e6 | Only one key question was identified in the preparatory phase:-What are the biological barriers within the gastrointestinal tract to ingested exogenous RNAs? |
| cord-022889-lv6fy6e6 | Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi Detection of Plant miRNAs Abundance in Human Breast Milk In silico identification of plant miRNAs in mammalian breast milk exosomes-- a small step forward? |
| cord-022889-lv6fy6e6 | Selected full- text studies were analysed for their relevance to answering the following key question:-Is there evidence for influence of exogenous plant ncRNAs on the gut microbiota related to the immune system? |
| cord-022889-lv6fy6e6 | Since these findings are important for the risk assessment of ncRNA- based GM plants, the key question was presented in its positive and negative forms as follow: are there studies describing the presence of exogenous RNAs in the biological fluids and tissues of humans and/or animals? |
| cord-022889-lv6fy6e6 | Studies were further evaluated for their relevance to answer the key questions identified for this section:-What are the pharmacokinetic properties of RNA- based therapeutics? |
| cord-022889-lv6fy6e6 | The complex exogenous RNA spectra in human plasma: an interface with human gut biota? |
| cord-022889-lv6fy6e6 | The complex exogenous RNA spectra in human plasma: an interface with human gut biota? |
| cord-022889-lv6fy6e6 | The key questions identified to refine the literature search for this specific topic were:-Is there evidence of any toxicological effects of plant- derived dietary exogenous ncRNAs? |
| cord-022889-lv6fy6e6 | The key questions identified using the above key words were:-Which test methods or approaches are available to investigate the possible role of plant- derived exogenous ncRNAs on the immune system of humans or animals? |
| cord-022889-lv6fy6e6 | The search was refined by filtering for relevance to answering the identified key questions: is there any clear transport of exogenous ncRNAs into mammalian cells? |
| cord-022889-lv6fy6e6 | To assist and refine the search, studies were further filtered for their relevance to the key question identified: is the oral route of administration relevant for RNA- based therapeutic development? |
| cord-022889-lv6fy6e6 | To more appropriately cover this section and to refine the search, the following key questions were identified during the preparatory phase:-What is the general amount of RNAs naturally occurring in edible plants? |
| cord-022889-lv6fy6e6 | any natural vehicles for oral administration of exogenous ncRNAs? |
| cord-022889-lv6fy6e6 | bee pollen miRNAs in serum of mice Chemical modification patterns compatible with high potency dicer- substrate small interfering RNAs Is RNA interference involved in intrinsic antiviral immunity in mammals? |
| cord-022889-lv6fy6e6 | certain types of plant ncRNAs more or less stable than others? |
| cord-022889-lv6fy6e6 | derived extracellular vesicles attenuates arthritis in two mouse models Exosomes as a Nanodelivery System: a Key to the Future of Neuromedicine? |
| cord-022889-lv6fy6e6 | disease conditions modify the pharmacokinetic properties of RNAs when administered to mammals? |
| cord-022889-lv6fy6e6 | exogenous ncRNAs also used to exert RNAi effects in fish or birds? |
| cord-022889-lv6fy6e6 | exogenous ncRNAs consumed in an amount sufficient to exert a local biological effect?Are there other common examples of exogenous ncRNAs( other than plant- origin) that could exert a biological effect on the GI tract and its annex glands when ingested orally? |
| cord-022889-lv6fy6e6 | exogenous ncRNAs evaluated quantitatively? |
| cord-022889-lv6fy6e6 | exposure to RNAs change in different diet types? |
| cord-022889-lv6fy6e6 | human or animal immune response(s), innate or adaptive, are possibly associated with administration of plant- derived exogenous ncRNAs? |
| cord-022889-lv6fy6e6 | is it known about the pharmacodynamic properties of RNA- based therapeutics? |
| cord-022889-lv6fy6e6 | key questions were identified and the studies then further filtered for their relevance to the these:-Are exogenous RNAs taken up by mammalian cells? |
| cord-022889-lv6fy6e6 | molecular mechanisms are involved in exogenous ncRNAs trafficking inside the cell? |
| cord-022889-lv6fy6e6 | ncRNAs- based therapeutics-delivered by oral administration or other GI tract routes of administration- exert a biological effect in the GI tract or its annex glands? |
| cord-022889-lv6fy6e6 | orthologous of environmental RNAs transporters in lower organisms( i.e. SID family of proteins) involved in the mammalian exogenous ncRNA mechanism of uptake? |
| cord-022889-lv6fy6e6 | percentage of total plant RNAs are ncRNAs, miRNAs, siRNAs, lncRNAs or dsRNAs? |
| cord-022889-lv6fy6e6 | possible interactions related to unintended RNAi- mediated gene regulation? |
| cord-022889-lv6fy6e6 | possibly mediated by administration of plant- derived ncRNAs? |
| cord-022889-lv6fy6e6 | so, what makes a plant ncRNA more stable than its animal( mammalian) counterpart? |
| cord-022889-lv6fy6e6 | stability properties under GI tract conditions normally evaluated? |
| cord-022889-lv6fy6e6 | the literature describe negative results or contradictory results regarding the possible biological effect of ncRNAs when consumed orally? |
| cord-022889-lv6fy6e6 | the toxicological effects related to RNAi- mediated interaction with the human or animal genome? |
| cord-022889-lv6fy6e6 | there studies contradicting the presence of exogenous RNAs in the biological fluids and tissues of humans and/or animals? |
| cord-022889-lv6fy6e6 | types of formulation( delivery vehicles) are tested for RNA- based therapeutics for the oral route of administration or other gastrointestinal tract routes of administration? |