bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
convalescent plasma	663
extracellular vesicles	576
summary conclusion	561
flow cytometry	170
plasma therapy	151
derived evs	146
electron microscopy	146
cell lines	145
nanoparticle tracking	138
tracking analysis	134
breast cancer	130
whole blood	125
western blot	111
endothelial cells	110
prostate cancer	104
human plasma	102
cancer cells	100
stem cells	98
plasma samples	95
bone marrow	94
amino acid	94
stem cell	92
mass spectrometry	91
acute respiratory	87
cancer patients	83
multiple myeloma	83
usa introduction	81
plasma exchange	81
extracellular vesicle	81
exclusion chromatography	79
transmission electron	77
plasma proteins	77
ng ml	76
plasma protein	73
plasma transfusion	73
derived exosomes	72
lung cancer	72
recipient cells	70
derived extracellular	69
respiratory syndrome	68
amino acids	67
cancer cell	67
molecular weight	65
mesenchymal stem	64
size exclusion	64
clinical trials	63
severe acute	63
western blotting	62
cell culture	61
cell line	60
blood samples	60
critically ill	58
immune response	57
ill patients	57
blood cells	57
ev isolation	57
differentially expressed	57
cell types	56
source plasma	56
lyophilized plasma	56
mg kg	55
factor viii	54
liquid biopsy	54
red blood	54
plasma donation	53
small rna	52
healthy controls	52
platelet activation	51
risk factors	49
size distribution	49
blood donation	49
density gradient	48
coronavirus disease	47
conditioned media	47
platelet aggregation	47
differential ultracentrifugation	47
small extracellular	47
antibody titers	46
nucleic acids	46
gene expression	46
plasma products	46
antibody titer	45
isolated evs	44
evs derived	44
severe covid	44
apc resistance	44
ev markers	44
tumour cells	44
ev cargo	43
immune system	43
platelet count	43
surface markers	43
blood products	42
intercellular communication	42
viral inactivation	42
enveloped viruses	41
ev release	41
plasma cell	41
colorectal cancer	41
neutralizing antibodies	41
side effects	40
frozen plasma	40
significantly higher	40
dried plasma	40
endothelial cell	39
low molecular	39
evs isolated	39
ebola virus	39
protein content	39
mg dl	38
conditioned medium	38
isolation methods	38
coagulation factors	37
smooth muscle	37
differential centrifugation	37
evs released	37
free dna	36
cord uid	36
patients treated	36
doc id	36
plasma treatment	36
clinical trial	35
blood plasma	35
syndrome coronavirus	34
neutralizing antibody	34
control group	34
proteomic analysis	34
caprylic acid	34
oxidative stress	34
myocardial infarction	34
isolated using	34
plasma evs	34
culture media	34
cells treated	34
ev subpopulations	34
eligibility criteria	33
important role	33
activated protein	33
plasma exudation	33
immune cells	32
risk factor	32
tissue factor	32
wound healing	32
healthy subjects	32
epithelial cells	32
mortality rate	32
significantly increased	31
cell communication	31
intensive care	31
protein cargo	31
united states	31
fresh frozen	31
plasma cells	31
willebrand factor	31
target cells	31
small evs	31
respiratory distress	30
present study	30
performed using	30
thrombocytopenic purpura	30
cell surface	30
healthy volunteers	30
early detection	29
data suggest	29
first time	29
ev production	29
peripheral blood	29
protein markers	29
growth factor	29
protein binding	29
therapeutic plasma	29
tumour microenvironment	29
plasma amino	28
protein expression	28
may also	28
analysis revealed	28
total protein	28
exosomes derived	28
renal failure	28
plasma donors	27
thrombotic thrombocytopenic	27
adverse events	27
another study	27
infectious diseases	27
circulating evs	27
hemorrhagic shock	27
host cells	27
patients compared	27
normal range	27
particle size	27
venous thrombosis	27
von willebrand	26
mouse model	26
significant differences	26
surface marker	26
nucleic acid	26
informed consent	26
rna sequencing	26
distress syndrome	26
significantly reduced	25
median age	25
platelet concentrates	25
cd cd	25
inflammatory response	25
human umbilical	25
quality control	25
culture medium	25
clotting time	25
novel coronavirus	25
viral reduction	25
extracellular matrix	25
analysis showed	25
stromal cells	25
commercially available	25
human blood	25
cell death	24
cell proliferation	24
results indicate	24
results suggest	24
plasminogen activator	24
growth factors	24
poorly understood	24
tumour growth	24
organ failure	24
thrombus formation	24
lung injury	24
ev numbers	24
plasma membrane	24
plasma fractionation	23
membrane vesicles	23
widely used	23
blood loss	23
dna damage	23
mesenchymal stromal	23
public health	23
ms ms	23
blood pressure	23
viral load	23
plasma levels	23
virus infection	23
hav ig	23
ex vivo	23
cell type	23
threatening covid	23
umbilical cord	23
particles ml	23
exosomes isolated	23
infectious agents	23
significant difference	23
recent studies	22
poor prognosis	22
derived ev	22
ev protein	22
body fluids	22
dependent manner	22
ev preparations	22
single ev	22
septic shock	22
cerebrospinal fluid	22
evs may	22
outer membrane	22
blood cell	22
thrombin generation	22
drug administration	21
measured using	21
ev proteins	21
degradation products	21
increased levels	21
healthy individuals	21
significantly lower	21
inflammatory cytokines	21
analysed using	21
blot analysis	21
ev populations	21
antibody levels	21
hospitalized patients	21
tumour progression	21
wide range	21
viral safety	21
data show	21
circulating tumor	21
soluble fibrin	21
randomized controlled	21
previous studies	21
early diagnosis	21
clinical studies	21
nervous system	21
ev surface	21
vein thrombosis	21
pg ml	21
ovarian cancer	21
evs showed	21
associated proteins	20
drug resistance	20
room temperature	20
determine whether	20
molecular mechanisms	20
exosome secretion	20
clotting factors	20
cancer detection	20
small rnas	20
coagulation factor	20
therapeutic potential	20
cellular uptake	20
factor vii	20
plasma collection	20
different types	20
pathogen reduction	20
spanish flu	20
clinical symptoms	20
nach der	20
type diabetes	20
blood components	20
healthy donors	20
pulse sensing	20
clinical applications	20
exchange chromatography	20
plasma proteome	19
acute phase	19
significant increase	19
virus inactivation	19
umbilical vein	19
platelet counts	19
may provide	19
east respiratory	19
one patient	19
high levels	19
serum samples	19
clinical use	19
high risk	19
two different	19
large evs	19
cd evs	19
infected cells	19
animal models	19
resistive pulse	19
brain injury	19
revised eligibility	19
ev secretion	19
physical activity	19
middle east	19
plasma sample	19
wild type	19
bleeding complications	19
pathway analysis	19
potential biomarkers	19
cell derived	19
msc evs	18
differential expression	18
systematic review	18
treated patients	18
airway mucosa	18
plasma pools	18
statistically significant	18
sample size	18
may contribute	18
confocal microscopy	18
mechanical ventilation	18
muscle cells	18
tumour cell	18
antibody responses	18
cell lung	18
ev biogenesis	18
total evs	18
light chain	18
blood donors	18
prothrombin time	18
antibody response	18
disease progression	18
diabetes mellitus	18
pulmonary embolism	18
pathogen inactivation	18
different ev	18
ev size	18
purified evs	18
cancer progression	18
uv light	18
venous thromboembolism	18
culture conditions	18
findings suggest	17
mirna expression	17
controlled trial	17
ev uptake	17
coronavirus infection	17
ultraviolet light	17
markers cd	17
vascular permeability	17
deep vein	17
case series	17
tangential flow	17
blood flow	17
new york	17
vein endothelial	17
signalling pathways	17
type ii	17
platelet function	17
iu ml	17
increased expression	17
evs secreted	17
data demonstrate	17
family members	17
flow filtration	17
flow cytometer	17
cell evs	17
clinically normal	17
thrombotic events	17
protein levels	17
cell activation	17
regenerative medicine	17
size range	17
blood group	17
key role	17
medical center	17
ev samples	17
commonly used	17
expression levels	17
signalling pathway	17
cell function	17
epithelial cell	16
biomarker discovery	16
evs using	16
assessed using	16
previously shown	16
der regel	16
reference interval	16
passive immunization	16
may lead	16
evs containing	16
drug delivery	16
triple negative	16
potential therapeutic	16
brain barrier	16
coronary artery	16
future studies	16
crc patients	16
higher levels	16
virus disease	16
immune responses	16
feline plasma	16
exosome isolation	16
free plasma	16
coagulation parameters	16
cells using	16
three different	16
times higher	16
replacement therapy	16
light scattering	16
traumatic brain	16
tumor dna	16
total rna	16
plasma infusion	16
small cell	16
respiratory failure	16
ischemic stroke	16
preliminary data	16
patients received	16
ig titers	16
pilot study	16
monoclonal antibody	16
proteomic profiling	16
human igg	16
gradient ultracentrifugation	16
patients undergoing	16
cytokine storm	16
infectious disease	16
circulating extracellular	16
currently available	16
adverse effects	15
dendritic cells	15
clinical signs	15
day mortality	15
solvent detergent	15
year old	15
evs produced	15
plasma exudate	15
previously described	15
ig products	15
increased risk	15
blood safety	15
central nervous	15
serious adverse	15
ev research	15
cd exo	15
plasma collected	15
viral infections	15
oral anticoagulation	15
thromboplastin time	15
bacterial evs	15
ev treatment	15
treated cells	15
bleeding time	15
case report	15
national institutes	15
negative breast	15
ev concentration	15
inflammatory mediators	15
blood coagulation	15
multiple organ	15
mg ml	15
machine learning	15
characterized using	15
plasma derived	15
similar results	15
data analysis	15
patients showed	15
blood transfusion	15
ev quantification	15
elevated levels	15
early stage	15
results demonstrate	15
dependent enhancement	15
studies will	15
poor plasma	15
thrombin inhibitors	15
type i	15
small ev	15
rich plasma	15
exosomal mir	15
cell viability	15
potential role	15
urine samples	15
point mutation	15
bone metastasis	15
highly sensitive	15
different cell	15
expression analysis	15
immune cell	15
anticoagulant therapy	14
years old	14
wt mice	14
using differential	14
red cell	14
thrombin time	14
determined using	14
mirna cargo	14
world health	14
cancer diagnosis	14
monoclonal gammopathy	14
labelled evs	14
abundant proteins	14
network structure	14
cells may	14
retrospective study	14
specific markers	14
thermo fisher	14
low ph	14
significantly decreased	14
using flow	14
hiv infection	14
quantified using	14
acute lung	14
will provide	14
predictive value	14
induced platelet	14
liquid biopsies	14
biological activity	14
dnase turbo	14
fold change	14
pancreatic cancer	14
studies suggest	14
national institute	14
blood collection	14
guinea pig	14
mitochondrial dysfunction	14
antithrombin iii	14
ev detection	14
pooled plasma	14
clinical data	14
surface protein	14
sars patients	14
monoclonal antibodies	14
ev yield	14
marrow plasmacytosis	14
results showed	14
und die	14
gel electrophoresis	14
plasma units	14
donor centre	14
results show	14
studies showed	14
dynamic range	14
hydrostatic pressure	14
adipose tissue	14
liquid chromatography	14
different isolation	14
immunodeficiency virus	14
cell cultures	14
pulmonary edema	14
study revealed	14
analysis using	14
symptom onset	14
plasma using	14
controlled trials	14
better understanding	14
airway lumen	13
well known	13
may serve	13
specific antibodies	13
rna cargo	13
liver disease	13
generation sequencing	13
patients receiving	13
patients without	13
bei der	13
least one	13
respiratory infections	13
thrombotic complications	13
normal plasma	13
cell cycle	13
thrombin receptor	13
weight heparin	13
fisher scientific	13
recent years	13
cell migration	13
basal cells	13
reduced mortality	13
inhibitory effect	13
organ dysfunction	13
intravenous immunoglobulin	13
body weight	13
significant reduction	13
essential amino	13
fluorescently labelled	13
pa activity	13
protease inhibitors	13
study aimed	13
human brain	13
molecular cargo	13
taken together	13
blood supply	13
clinical features	13
health organization	13
rights reserved	13
dynamic light	13
using convalescent	13
coagulation system	13
fibrinolytic system	13
medical research	13
control samples	13
ev released	13
lupus anticoagulant	13
fold higher	13
plasma recipients	13
national cancer	13
chain proteinuria	13
fractionation process	13
fibrin monomer	13
within hours	13
acute myocardial	13
samples collected	13
sevs isolated	13
expressed proteins	13
der spender	13
exosomal rna	13
study group	13
investigate whether	13
showed significant	13
using nanoparticle	13
heat treatment	13
reactive protein	13
highly purified	13
human immunodeficiency	13
study will	13
exosomal mirna	12
expression patterns	12
ethanol fractionation	12
gene ontology	12
engineered evs	12
activator inhibitor	12
ev concentrations	12
fold increase	12
data suggests	12
clinical improvement	12
care unit	12
lymph nodes	12
nk cells	12
pluripotent stem	12
bronchial asthma	12
plasma concentrations	12
proteome analysis	12
high purity	12
drug discovery	12
therapeutic effect	12
centre staff	12
vesicles introduction	12
convalescent sera	12
vascular smooth	12
exosome markers	12
luminal entry	12
el paso	12
cognitive impairment	12
magnetic beads	12
therapeutic efficacy	12
chain reaction	12
may play	12
good manufacturing	12
also used	12
convalescent serum	12
per ml	12
pd patients	12
deficient plasma	12
hepatocellular carcinoma	12
per cell	12
swarm detection	12
bovine serum	12
protein biomarkers	12
largely unknown	12
factor xii	12
signal transduction	12
neurological disorders	12
normal human	12
tissue culture	12
spike antibody	12
basement membrane	12
platelet adhesion	12
cohort study	12
study showed	12
patient plasma	12
zeta potential	12
two groups	12
mast cells	12
total ev	12
heart failure	12
factor ix	12
cell therapy	12
great potential	12
platelet surface	12
parental cells	12
using two	12
exosomal markers	12
specific ev	12
crucial role	12
clot formation	12
standard deviation	12
expression level	12
disease control	12
therapeutic strategies	12
leading cause	12
laboratory tests	12
affected cats	12
scanning electron	12
heparin therapy	12
neurodegenerative diseases	12
gradient centrifugation	12
large scale	12
viral rna	12
fluorescence microscopy	12
immune globulin	12
therapeutic applications	12
imaging flow	11
functional assays	11
coagulation tests	11
preliminary results	11
level digraph	11
nile virus	11
characterize evs	11
plasma donor	11
novel biomarkers	11
atypical hus	11
plasma ev	11
also observed	11
membrane protein	11
cd expression	11
vascular leakage	11
epidermal growth	11
sars coronavirus	11
durch die	11
therapeutic strategy	11
may occur	11
three days	11
diabetic patients	11
lavage fluid	11
expression profiles	11
derived sevs	11
complement activation	11
pivotal role	11
clotting assays	11
cam evs	11
mitochondrial dna	11
uremic syndrome	11
acceptor cells	11
thrombin inhibitor	11
patients suffering	11
data collection	11
high dose	11
platelet reactivity	11
circulating cell	11
time points	11
cell carcinoma	11
bacterial cells	11
intravenous administration	11
serum levels	11
und der	11
lipid bilayer	11
ethics committee	11
macrophage activation	11
vivo studies	11
raman spectroscopy	11
midwest city	11
will use	11
vascular endothelial	11
ad patients	11
us fda	11
western blots	11
ev analysis	11
low dose	11
brain tissue	11
also significantly	11
per year	11
may cause	11
blood product	11
crispr cas	11
prothrombin fragment	11
necrosis factor	11
lung disease	11
partial thromboplastin	11
reference materials	11
polymerase chain	11
hong kong	11
detection limit	11
high throughput	11
cd ev	11
animal model	11
activated platelets	11
viii concentrate	11
within days	11
plasma may	11
severe influenza	11
coagulation activation	11
infectious peritonitis	11
lung diseases	11
biological fluids	11
cell membrane	11
endoplasmic reticulum	11
donor selection	11
feline infectious	11
circulating ev	11
thrombolytic therapy	11
high sensitivity	11
der erythrozyten	11
using different	11
blood donor	11
will allow	11
lymph node	11
evs compared	11
plasma dna	11
creative commons	11
renal function	11
clinical application	11
compassionate use	11
red cross	11
expression profile	11
misev guidelines	11
normal cells	11
cancer institute	11
yon willebrand	11
manufacturing processes	11
innate immune	11
protein spots	11
potential biomarker	11
high molecular	11
related diseases	11
mayo clinic	11
also showed	11
using size	11
exosome release	11
asthmatic airways	11
nm ss	11
associated protein	11
validation studies	11
cells showed	11
viral infection	10
significantly improved	10
pore size	10
patient samples	10
thromboembolic complications	10
convalescent blood	10
evs contain	10
based therapies	10
bovine milk	10
control subjects	10
significantly elevated	10
invasive biomarkers	10
based method	10
component analysis	10
factor xiii	10
detergent treatment	10
mortality rates	10
fully understood	10
delivery systems	10
leiden mutation	10
free protein	10
general population	10
oxidized ldl	10
disease patients	10
canadian blood	10
gbm cells	10
next generation	10
readily available	10
cells release	10
four patients	10
oral anticoagulant	10
feline multiple	10
continuous infusion	10
ev characterization	10
cell lysates	10
kg bw	10
two patients	10
auf die	10
clinical course	10
data indicate	10
cell free	10
novel therapeutic	10
liver failure	10
human serum	10
manufacturing process	10
barrier function	10
behaviour change	10
knowledge users	10
plasma product	10
bronchoalveolar lavage	10
evs also	10
different concentrations	10
murine macrophages	10
rna species	10
physiological conditions	10
ev collection	10
type specific	10
rna expression	10
central role	10
cells introduction	10
human disease	10
hours post	10
ev mirna	10
west nile	10
small molecules	10
induced pluripotent	10
bioactive molecules	10
cardiac events	10
cell adhesion	10
cartilage regeneration	10
airway mucosal	10
influenza pneumonia	10
major depressive	10
metastatic niche	10
randomized clinical	10
alkaline phosphatase	10
pathological conditions	10
igg preparations	10
high expression	10
treated plasma	10
derived small	10
specific mirnas	10
disease biomarkers	10
results obtained	10
abo blood	10
occlusive disease	10
final concentration	10
dry heat	10
pal antigen	10
cells expressing	10
kidney disease	10
therapeutic approach	10
using ultracentrifugation	10
different methods	10
platelet products	10
milk evs	10
coding rnas	10
plasma triacylglycerol	10
circulating micrornas	10
proteins may	10
research council	10
depressive disorder	10
isolation method	10
dnase i	10
analysis methods	10
therapeutic use	10
thawed plasma	10
ion exchange	10
one case	10
small size	10
tissue damage	10
five patients	10
well suited	10
specific biomarkers	10
cardiovascular disease	10
activation markers	10
clinical practice	10
convalescent whole	10
sensitive strains	9
factor receptor	9
cardiovascular risk	9
individual evs	9
sera option	9
japan introduction	9
related acute	9
transfused patients	9
tf expression	9
expressed mirnas	9
sequencing data	9
apc sensitivity	9
seminal plasma	9
lytic lesions	9
clinical outcomes	9
studies using	9
expanded access	9
novel biomarker	9
antibody therapy	9
may represent	9
cell interactions	9
human cells	9
molecular markers	9
current methods	9
increased blood	9
patients develop	9
successfully used	9
immune plasma	9
disease severity	9
carcinoma cells	9
human monocytes	9
cell morphology	9
donor screening	9
previously reported	9
tandem mass	9
preliminary report	9
venous blood	9
blood vessel	9
analysis identified	9
molecular changes	9
state university	9
molecular mechanism	9
culture supernatant	9
positive evs	9
cell growth	9
sulfur mustard	9
acid precipitation	9
novel antiviral	9
fractionated products	9
surface expression	9
serum albumin	9
severe bleeding	9
cytokine production	9
bacterial species	9
peer review	9
spinal cord	9
successful treatment	9
brain tissues	9
oa chondrocytes	9
protein concentrations	9
epithelial lining	9
neuronal cells	9
vor der	9
national university	9
viral diseases	9
seq data	9
reactive oxygen	9
postoperative day	9
abundance proteins	9
time course	9
library preparation	9
circulatory overload	9
study included	9
free nucleic	9
risk markers	9
clinical study	9
evs resulted	9
uk introduction	9
viral shedding	9
tof ms	9
high quality	9
fibrinogen levels	9
com ccm	9
will help	9
cancer evs	9
including exosomes	9
von der	9
single particle	9
cancer therapy	9
trauma patients	9
passive immunity	9
using anti	9
plasma derivatives	9
challenging due	9
sev content	9
better understand	9
red cells	9
functional studies	9
apheresis plasma	9
data showed	9
factor xa	9
diagnostic criteria	9
protein composition	9
blood type	9
plasma sevs	9
proteins identified	9
spike protein	9
proteins involved	9
liver transplantation	9
evs obtained	9
thp cells	9
specific evs	9
first step	9
cell populations	9
increased plasma	9
prospective study	9
significantly different	9
swine model	9
containing covid	9
proteomics analysis	9
reperfusion injury	9
protein products	9
chagas disease	9
exposed patients	9
supplemental digital	9
ev mirnas	9
biological processes	9
digital content	9
gold standard	9
viral loads	9
skeletal muscle	9
diarrheal hus	9
systemic circulation	9
flow cytometric	9
patients developed	9
binding protein	9
cs sevs	9
prothrombin fragments	9
two weeks	9
blood derivatives	9
significant changes	9
bacterial infections	9
human lung	9
treat covid	9
beneficial effects	9
los angeles	9
soluble proteins	9
relatively high	9
evs play	9
blood banking	9
progenitor cell	9
may affect	9
negative control	9
domains framework	9
photochemical treatment	9
airway absorption	9
membrane proteins	9
linked immunosorbent	9
seven days	9
der blutspende	9
newly developed	9
escherichia coli	9
different sources	9
vivo model	9
gewinnung von	9
old man	9
chronic inflammation	9
nsclc patients	9
reference intervals	9
various types	9
ill covid	9
data obtained	9
naturally occurring	9
theoretical domains	9
alphav beta	9
culture supernatants	9
proinflammatory cytokines	9
urinary extracellular	9
clinical efficacy	9
bulk plasma	9
iodixanol density	9
dedicated viral	9
cs control	9
viral replication	9
effective treatment	9
intranasal administration	9
raman spectra	9
developing countries	9
fxii deficiency	9
last years	9
surface proteins	9
overall survival	9
urinary evs	9
correlated well	9
associated markers	9
methylene blue	9
recent study	9
quantify evs	9
clinically relevant	9
copyright holder	9
derived vesicles	9
major role	9
target cell	9
autoimmune diseases	9
single cell	9
data may	8
blood services	8
dbh gene	8
metastatic potential	8
high incidence	8
androgen receptor	8
newly born	8
cardiovascular diseases	8
study provides	8
liver cirrhosis	8
protein ratio	8
proteomic technologies	8
crc cells	8
therapeutic range	8
cervical cancer	8
new therapeutic	8
hek cells	8
long term	8
case reports	8
hyperimmune immunoglobulin	8
mrna expression	8
arterial thrombosis	8
high concentrations	8
current study	8
calcium concentration	8
therapeutic target	8
phenotypic changes	8
sev marker	8
protein amount	8
functional activity	8
single molecule	8
remains unknown	8
ev loading	8
human nasal	8
invasive biomarker	8
msc therapy	8
obtained using	8
therapeutic agents	8
protein profile	8
also found	8
vast majority	8
study using	8
squamous cell	8
renal disease	8
passive immunotherapy	8
cancer development	8
primary tumour	8
mucosal surface	8
national blood	8
clinical samples	8
specific activity	8
ev particles	8
nitric oxide	8
also demonstrated	8
cord blood	8
evs enriched	8
may influence	8
sulphate precipitation	8
free medium	8
proteomic profile	8
total cholesterol	8
sample processing	8
donor cells	8
ev biomarkers	8
particle concentration	8
body mass	8
arachidonic acid	8
passive antibody	8
also reduced	8
clinical outcome	8
rna virus	8
marrow aspirates	8
ultracentrifugation method	8
patients transfused	8
cancer risk	8
vivo experiments	8
culture systems	8
protein profiles	8
density lipoprotein	8
immunosorbent assay	8
highly abundant	8
produce evs	8
two hours	8
affinity chromatography	8
therapeutic options	8
mdd subjects	8
patients recovered	8
manufacturing practices	8
antiviral drugs	8
biologically active	8
bleeding tendency	8
clinical characteristics	8
amniotic fluid	8
recovered covid	8
tube formation	8
photochemical inactivation	8
significant improvement	8
esterase inhibitor	8
highly expressed	8
pfu ml	8
reverse transcriptase	8
may reflect	8
induced apoptosis	8
sodium citrate	8
critical role	8
terumo bct	8
may prove	8
chronic bronchitis	8
control evs	8
multiple sclerosis	8
cancer stem	8
mit der	8
marker expression	8
cvd risk	8
tunable resistive	8
circulating tumour	8
als patients	8
differential gene	8
sm exposed	8
diastolic bp	8
wnt signalling	8
positively charged	8
significantly upregulated	8
individual donations	8
ev associated	8
modern plasma	8
rna transfer	8
hirudin antibodies	8
log pfu	8
capillary leakage	8
human urine	8
protease inhibitor	8
lateral sclerosis	8
severely ill	8
specific proteins	8
exosome biogenesis	8
flow fractionation	8
cytometry analysis	8
gene therapy	8
written informed	8
liver enzymes	8
plasma extracellular	8
lower mortality	8
cd patients	8
using nta	8
study demonstrates	8
hcv rna	8
recently demonstrated	8
cancer introduction	8
fibrinolytic activity	8
neurological signs	8
nonenveloped viruses	8
glioma cells	8
containing evs	8
metastatic breast	8
induced aggregation	8
signaling pathways	8
tg ml	8
characterized according	8
prp tse	8
total tau	8
identified using	8
patients introduction	8
induced oxidative	8
stromal cell	8
electron microscope	8
evs isolation	8
high level	8
acid concentrations	8
myeloma patients	8
acute liver	8
ev marker	8
plasma donations	8
plasma use	8
using evs	8
ammonium sulphate	8
amyotrophic lateral	8
distinct populations	8
based methods	8
novel method	8
clinical settings	8
protein concentration	8
stably expressing	8
damage control	8
vitro studies	8
network analysis	8
myc amplified	8
university hospital	8
vesicles released	8
bleeding episodes	8
hemostatic parameters	8
pci mrna	8
large amounts	8
transfusion transmission	8
knowledge translation	8
sp i	8
analysis indicated	8
primary human	8
recombinant hirudin	8
cancer biomarkers	8
potential donors	8
von blut	8
auch die	8
ev subtypes	8
mean diameter	8
com scientificreports	8
airway epithelium	8
cells via	8
artery disease	8
will likely	8
vitro study	8
higher anti	8
normal values	8
ms analysis	8
pregnant women	8
epithelial barrier	8
patient year	8
digraph analysis	8
medical university	8
thromboembolic events	8
ev fraction	8
human subjects	8
safety indicators	8
ascorbic acid	8
nmol i	8
early safety	8
tumor necrosis	8
positively correlated	8
spanish influenza	8
hc ii	8
plasma leakage	8
acid ph	8
may result	7
cellular communication	7
clotting assay	7
muscle cell	7
elevated anti	7
within minutes	7
convalescent covid	7
atypical plasma	7
acid treatment	7
blood transfusions	7
liquid plasma	7
clot lysis	7
sizeexclusion chromatography	7
principal component	7
mirna content	7
adhesion molecules	7
hemostatic system	7
rag ko	7
protein kinase	7
several proteins	7
ev derived	7
rescue therapy	7
protein contaminants	7
control study	7
amongst others	7
cancer circulating	7
clotting times	7
university school	7
actin fs	7
laboratory findings	7
clp mice	7
statistical significance	7
werden kann	7
mouse models	7
using elisa	7
activated coagulation	7
donor plasma	7
reduced ev	7
donor deferral	7
immobilized heparin	7
dmem supplemented	7
increasing evidence	7
cell tumors	7
apoptotic bodies	7
inhibitor patients	7
york city	7
functional effects	7
based ev	7
time period	7
safety profile	7
johns hopkins	7
snake venom	7
bcc proliferation	7
model viruses	7
human platelet	7
quality assurance	7
associated mirnas	7
skin necrosis	7
platelet factor	7
anticoagulant effect	7
airway epithelial	7
human diseases	7
well understood	7
der spende	7
ethanol supernatant	7
experiments will	7
cleaving protease	7
treatment reduced	7
via evs	7
inflammatory effects	7
author funder	7
culture system	7
born neurons	7
filter system	7
significantly altered	7
gla domain	7
eukaryotic cells	7
dass die	7
binding domain	7
pc gr	7
fluorescence intensity	7
minimally invasive	7
rpe cells	7
us food	7
based assays	7
among patients	7
transfection reagent	7
discriminant analysis	7
gp ib	7
pepsin digestion	7
detect evs	7
canada introduction	7
gastric cancer	7
prognostic marker	7
healthy women	7
serial centrifugation	7
healthy control	7
delivery system	7
present work	7
serum mir	7
granted medrxiv	7
neurodegenerative disease	7
notch signaling	7
different subpopulations	7
dermal fibroblasts	7
circulating levels	7
least days	7
igg products	7
studies demonstrated	7
pig trachea	7
closure time	7
showed significantly	7
biological samples	7
sevs group	7
surface antigen	7
disease detection	7
findings indicate	7
years ago	7
following treatment	7
surface area	7
ev field	7
veterinary medicine	7
correlation coefficient	7
atomic force	7
protein components	7
high density	7
clotting tests	7
will enable	7
standard curve	7
ev rna	7
chronic obstructive	7
patient groups	7
parental cell	7
significant decrease	7
test samples	7
individual outcomes	7
blood donations	7
carotid artery	7
heart rate	7
asthmatic sputa	7
mechanisms involved	7
concentration range	7
sequential ultracentrifugation	7
results revealed	7
regression model	7
cells also	7
possible mechanisms	7
may therefore	7
und nach	7
blut und	7
haematopoietic stem	7
direct sequencing	7
microfluidic resistive	7
ad mice	7
significantly downregulated	7
receptor binding	7
study also	7
vehicle control	7
previously showed	7
supplementary table	7
induced evs	7
activating peptide	7
epithelial damage	7
transgene expression	7
membrane dyes	7
ev isolates	7
results demonstrated	7
based assay	7
cd positive	7
ist eine	7
two covid	7
guinea pigs	7
genomic alterations	7
received convalescent	7
via extracellular	7
improved survival	7
cognitive function	7
days post	7
diagnostic test	7
log reduction	7
acute myeloid	7
found elevated	7
based therapy	7
hit type	7
wird durch	7
research team	7
collagen production	7
platelet rich	7
therapeutic effects	7
recovered patients	7
rna delivery	7
gap closure	7
mehr als	7
icu admission	7
will need	7
prothrombin complex	7
myeloid leukaemia	7
healthcare workers	7
isolate evs	7
angina pectoris	7
chromogenic assay	7
sta aptt	7
trend towards	7
nm nanofiltration	7
severe disease	7
transmembrane protein	7
time point	7
plasma administration	7
ev content	7
even though	7
ev purification	7
four hours	7
reporter system	7
health care	7
viral validation	7
based liquid	7
intravenous injection	7
nach den	7
patients diagnosed	7
purification methods	7
macsplex exosome	7
many different	7
copy number	7
cell motility	7
bioreactor system	7
fatty acids	7
using riboflavin	7
fibrinogen concentration	7
mirna profiling	7
host immune	7
exosome treatment	7
cargo release	7
different culture	7
der transfusion	7
resistant strains	7
fibrin formation	7
made using	7
diagnostic markers	7
intravascular coagulation	7
hemolytic uremic	7
turbidimetric assay	7
thymidine incorporation	7
detected using	7
within evs	7
significantly associated	7
dose heparin	7
equivalence group	7
high mortality	7
fatality rate	7
control cells	7
ko mice	7
evs based	7
protein electrophoresis	7
protein bound	7
supportive care	7
sample preparation	7
pathways involved	7
control groups	7
adhesion molecule	7
production steps	7
flow rate	7
time pcr	7
computed tomography	7
accessibility matrix	7
proteins associated	7
restriction enzyme	7
vesicle size	7
health emergency	7
ingenuity pathway	7
recipient antibody	7
sequential centrifugation	7
boehringer mannheim	7
ev core	7
least two	7
blood collected	7
humoral immune	7
combat casualties	7
fibrin clot	7
marker cd	7
age years	7
cell exosomes	7
patients using	7
mechanisms regulating	7
assay using	7
microvascular endothelial	7
last decade	7
protein aggregates	7
calculated using	7
force microscopy	7
quantitative proteomics	7
recent advances	7
lmw heparin	7
showed similar	7
circulating dna	7
tumour development	7
recipient cell	7
shape change	7
incubation time	7
resistant cell	7
fibrinolytic therapy	7
highly metastatic	7
serum protein	7
infected patients	7
factor levels	7
test analysis	7
factor concentrates	7
unfractionated heparin	7
currently used	7
therapeutic interventions	7
dna analysis	7
social distancing	7
evs purified	7
sequence motifs	7
binding proteins	7
exosome production	7
small number	7
iu kg	7
two distinct	7
weight proteins	7
different proteins	7
using transmission	7
der lagerung	7
communication via	7
protein profiling	7
senescent cells	7
ev population	7
high degree	7
control resuscitation	7
new biomarkers	7
bypass surgery	7
highly enriched	7
protein analysis	7
derived exosome	7
urgent need	7
mean values	7
heart disease	7
high doses	7
will require	7
preterm infants	7
including extracellular	7
small molecule	7
polyethylene glycol	7
current status	7
anion exchange	7
complex biological	7
around nm	7
therapeutic delivery	7
clinical setting	7
human induced	7
gradient purification	7
cells secrete	7
prepared using	7
acute coronary	7
data capture	7
additional studies	7
inflammatory cells	7
observation period	7
adverse reactions	7
reduction treatments	7
different stages	7
cigarette smoke	7
drug development	7
therapeutic targets	7
intact evs	7
significantly enhanced	7
particle analysis	7
live imaging	7
exosomal micrornas	6
novel ev	6
levels increased	6
treatment purposes	6
based proteomics	6
ml kg	6
independent growth	6
lung fibrosis	6
enrolled patients	6
antibody microarrays	6
ev biology	6
pediatric patients	6
hopkins university	6
tumour specific	6
zikv infection	6
foetal bovine	6
fibrin degradation	6
coding rna	6
mitovesicle levels	6
three patients	6
der apherese	6
induced changes	6
product quality	6
major risk	6
disseminated intravascular	6
higher sev	6
antibody microarray	6
similar size	6
treated mice	6
transmembrane proteins	6
information regarding	6
single evs	6
clotting factor	6
aerobic exercise	6
cell lysate	6
nanoscale flow	6
plasma concentration	6
granulation tissue	6
well established	6
position paper	6
examined using	6
cd counts	6
antiviral agents	6
microrna signatures	6
bone formation	6
cancer plasma	6
new zealand	6
thrombocyte count	6
mouse pci	6
resistant prostate	6
allowed without	6
severe bleedings	6
reuse allowed	6
inflammatory properties	6
surface plasmon	6
commons licence	6
cell counts	6
mrna targets	6
mass index	6
ev reference	6
mechanisms underlying	6
data provide	6
sterile water	6
ev sub	6
highly desirable	6
heparan sulphate	6
expressed cd	6
associated dna	6
weniger als	6
microrna expression	6
group compared	6
plasma components	6
well tolerated	6
multiple studies	6
normal platelet	6
human patients	6
also show	6
analysis demonstrated	6
targeted therapy	6
falciparum malaria	6
disease diagnosis	6
postcapillary venules	6
local ethics	6
will determine	6
cerebral ischemia	6
fluid stem	6
specific marker	6
several days	6
matched control	6
human mesenchymal	6
extracellular space	6
mit dem	6
early disease	6
intramural research	6
new evidence	6
high amounts	6
san diego	6
cord mesenchymal	6
neural stem	6
induced sputum	6
tf viia	6
regulatory authorities	6
metastatic disease	6
natural killer	6
posted june	6
pancreatic ductal	6
lopinavir ritonavir	6
optiprep density	6
one cat	6
active gbmsm	6
ros production	6
viral etiology	6
hippocampal neurogenesis	6
direct contact	6
mustard gas	6
rna analysis	6
blood vessels	6
isolated exosomes	6
diagnostic efficacy	6
brain derived	6
sinai medical	6
aged animals	6
also identified	6
electronic data	6
proteolytic activity	6
plasma exosomes	6
hospital stay	6
human platelets	6
circulating mirna	6
undergoing elective	6
specific igg	6
starting plasma	6
oxygen saturation	6
late endosomes	6
decreased levels	6
also shown	6
large animal	6
light scatter	6
oxygen species	6
will also	6
clinical status	6
tested using	6
high resolution	6
total particle	6
one hour	6
interferometric reflectance	6
total plasma	6
large number	6
evidence suggests	6
still unknown	6
acquired pneumonia	6
health science	6
recombinant factor	6
dendritic spines	6
asthma patients	6
complement cascade	6
side scatter	6
tissue biopsy	6
male mice	6
inflammatory processes	6
exon ii	6
delivery vehicle	6
promote tumour	6
significantly changed	6
protein fractions	6
mice models	6
der gewinnung	6
also known	6
recent developments	6
treating covid	6
possible role	6
specific patterns	6
marrow derived	6
version posted	6
investigational covid	6
fibrin complexes	6
oral application	6
plasma pool	6
zika virus	6
specific rna	6
significantly correlated	6
blood bank	6
donor antibody	6
resting platelets	6
traditional drugs	6
delivery vehicles	6
human cancer	6
previous study	6
pl im	6
arg gin	6
blood volume	6
dimer levels	6
regression analysis	6
patient outcomes	6
rna library	6
shaped morphology	6
acid minus	6
ev separation	6
thrombotic microangiopathy	6
exudate may	6
mit einem	6
specific cargo	6
nanoflow cytometry	6
colon cancer	6
sexually active	6
human islets	6
also performed	6
ciliary evs	6
late stage	6
citrated blood	6
ffp transfusion	6
leading causes	6
hepfn ko	6
therapeutic tools	6
derived products	6
mm caprylate	6
average size	6
melanocytic evs	6
received funding	6
protein microarrays	6
protein recovery	6
durch eine	6
products using	6
cells grown	6
markedly increased	6
glial cells	6
three methods	6
day precision	6
mean fluorescence	6
exoquick ultra	6
stent implantation	6
positive predictive	6
ohsv resistant	6
evaluated using	6
cytometric analysis	6
white blood	6
without permission	6
plasma mir	6
baseline values	6
cell biology	6
von blutkomponenten	6
capture evs	6
db db	6
donation programme	6
lupus anticoagulants	6
virus neutralization	6
heparin treatment	6
conditions used	6
using cell	6
fluorescent protein	6
aptt reagent	6
validated using	6
stellate cells	6
plaque assay	6
adenosine diphosphate	6
first study	6
patients will	6
lung infiltrates	6
neurological diseases	6
enveloped virus	6
manufacturing steps	6
induced acute	6
significantly less	6
low responders	6
potential therapy	6
endogenous dnase	6
controlled conditions	6
last months	6
droplet based	6
evs reduced	6
und oder	6
experimental conditions	6
fluorescent labelling	6
ionized calcium	6
mononuclear cells	6
pulmonary fibrosis	6
augmentation therapy	6
ev administration	6
spectrometry analysis	6
provide evidence	6
cell media	6
effective therapy	6
late phase	6
toxic proteins	6
extremely high	6
plasma containing	6
pulmonary arterial	6
molecule array	6
cardiac function	6
production process	6
large plasma	6
cystic fibrosis	6
plasma study	6
antithrombin agents	6
decreased expression	6
serum therapy	6
profiling revealed	6
cell marker	6
analysis method	6
remains unclear	6
donation center	6
biliary strictures	6
derived mscs	6
scientific research	6
six months	6
clinical utility	6
ev fractions	6
different time	6
safety update	6
antivenom production	6
target genes	6
several studies	6
may help	6
ev manufacturing	6
reporter cells	6
acinetobacter baumannii	6
resistant cells	6
cell cycles	6
high titers	6
blood level	6
pathogen interactions	6
mtbi patients	6
integrated knowledge	6
reported cases	6
aged rats	6
neck cancer	6
major cause	6
medium using	6
statistical analysis	6
inflammatory diseases	6
rat model	6
plasma obtained	6
three groups	6
factor deficiencies	6
chronic stress	6
situ hybridization	6
specific treatment	6
plasma volume	6
divalent cations	6
pathophysiological processes	6
wird die	6
specific protein	6
low levels	6
purified using	6
developing world	6
chromogenic substrate	6
laboratory test	6
epithelial shedding	6
high potential	6
human seminal	6
extra centrosomes	6
reverse transcription	6
among others	6
brain cells	6
sec fractions	6
pl aggregation	6
ph incubation	6
derived mesenchymal	6
mediate intercellular	6
pca patients	6
cell count	6
release extracellular	6
study reported	6
mediators may	6
pandemic influenza	6
cingulate cortex	6
study shows	6
cell myeloma	6
producing cells	6
virus infections	6
cancer types	6
takes place	6
human convalescent	6
two methods	6
mucosal exudation	6
vesicles derived	6
progenitor cells	6
yr cvd	6
isolation kit	6
underlying mechanisms	6
cells cultured	6
one another	6
high affinity	6
migration ability	6
thromboembolic disease	6
donor population	6
disease models	6
plasma cfdna	6
tissue regeneration	6
zu einer	6
heparin induced	6
white cells	6
infectious agent	6
gp iib	6
treatment group	6
treatment may	6
anterior cingulate	6
allergic reactions	6
microvascular permeability	6
patients treatment	6
driven opc	6
melanomic evs	6
including cancer	6
many studies	6
isolate exosomes	6
th cells	6
drug abuse	6
dna fragments	6
acute renal	6
released evs	6
antiviral strategies	6
ev subpopulation	6
pc cells	6
concentration ratio	6
per day	6
mrna levels	6
new drug	6
journal club	6
ev precipitation	6
ml plasma	6
take place	6
flow field	6
increased proliferation	6
calibration curve	6
ev heterogeneity	6
tau propagation	6
tnbc cells	6
taking advantage	6
human pancreas	6
higher expression	6
fibrin monomers	6
filopodia formation	6
transfusion transmitted	6
circulating microrna	6
melanoma cells	6
inactivation treatments	6
cell signalling	6
depleted fbs	6
significant risk	6
microfluidic platform	6
type plasminogen	6
feline coronavirus	6
san francisco	6
patients infected	6
dna cargo	6
related genes	6
proteomic analyses	6
one condition	6
log fc	6
one essential	6
paca cell	6
screening questions	6
mouse islets	6
rna content	6
expression pattern	6
targeted delivery	6
aus der	6
digital droplet	6
calu evs	6
positively associated	6
collection tubes	6
high concentration	6
affinity column	6
boyden chamber	6
national science	6
mit einer	6
case fatality	6
einsatz von	6
transgenic mouse	6
vwf release	6
identified proteins	6
related proteins	6
ucm blood	6
national research	6
coronary syndromes	6
bag system	6
successfully isolated	5
blood platelets	5
interviews will	5
immunogold labelling	5
will enhance	5
antiasthma drugs	5
recruitment strategy	5
inflammatory effect	5
different populations	5
metastasis suppressor	5
den richtlinien	5
particle count	5
eight patients	5
south korea	5
using plasma	5
specific surface	5
shh signalling	5
kras mutations	5
kg min	5
vwf levels	5
ev composition	5
surface charge	5
genes involved	5
urokinase receptor	5
vivo biodistribution	5
ev fingerprinting	5
collagen sponge	5
vitro plasma	5
blood operators	5
may prevent	5
endothelial damage	5
one hand	5
high gain	5
canonical pathways	5
nuclear transfer	5
urinary ev	5
thereby increasing	5
showed higher	5
much higher	5
pcr amplification	5
collagen type	5
fractionation industry	5
potential diagnostic	5
aml patients	5
cell neoplasms	5
specific antigen	5
platelet transfusions	5
abundant protein	5
age ys	5
ev number	5
isolation techniques	5
serum amyloid	5
isolating evs	5
showed increased	5
positive sevs	5
virus antibodies	5
significant adverse	5
absorption barrier	5
therapeutic response	5
altered expression	5
exercised mice	5
sickle cell	5
anticoagulant activity	5
acid metabolism	5
several different	5
msc derived	5
rna isolation	5
tumour dna	5
producer cells	5
old therapeutic	5
via differential	5
viral kill	5
using ultrafiltration	5
purification protocols	5
cell transplantation	5
derived cells	5
heat shock	5
hyperimmune plasma	5
enriched proteins	5
prognostic value	5
stage renal	5
american heart	5
used convalescent	5
small non	5
albumin levels	5
enriched evs	5
factors may	5
epithelial barriers	5
copies per	5
cd aptamer	5
buenos aires	5
cultured human	5
significantly greater	5
airway diseases	5
myeloid cells	5
deep venous	5
immunofluorescence staining	5
important roles	5
high prevalence	5
gene transcription	5
neuroprotective properties	5
rich source	5
quantitative proteomic	5
ischaemia reperfusion	5
bleeding disorder	5
using mouse	5
cells contain	5
lining cells	5
evs captured	5
therapy response	5
nanotracking analysis	5
personalized medicine	5
blood regulators	5
donor eligibility	5
total calcium	5
ethanol precipitate	5
host cell	5
several months	5
primary cell	5
hepatic stellate	5
high yield	5
specific exosomes	5
uev proteome	5
also increased	5
previously identified	5
pretreatment titre	5
empirical treatment	5
ad evs	5
tissue homoeostasis	5
bioinformatic analysis	5
beta integrin	5
described previously	5
human protein	5
based photochemical	5
coronary risk	5
cellular pathways	5
various cell	5
current pandemic	5
model system	5
mitochondrial origin	5
family history	5
sd treatment	5
transform infrared	5
immunoglobulin products	5
sample volume	5
biodistribution studies	5
local advisory	5
cultured endothelial	5
immune modulatory	5
kommt es	5
protein mass	5
translational research	5
implementing revised	5
activated factor	5
neck squamous	5
clinical manifestation	5
control measures	5
findings support	5
lipid membrane	5
stim plus	5
donation testing	5
systemic inflammation	5
primary neurons	5
dependent inhibition	5
des spenders	5
wide variety	5
metastatic lung	5
blood brain	5
gfp evs	5
health problem	5
single vesicle	5
therapeutic option	5
isev workshops	5
lipoprotein particles	5
infected individuals	5
old male	5
durch einen	5
end stage	5
prolonged aptt	5
treatment options	5
flow conditions	5
serine proteinase	5
quantitative pcr	5
physiological functions	5
database search	5
human cd	5
research institute	5
human bone	5
titer centers	5
us southwest	5
ms patients	5
die transfusion	5
ev functionality	5
alveolar type	5
developing new	5
using confocal	5
real time	5
using rt	5
ev function	5
access program	5
diseases may	5
therefore conclude	5
mucosal permeability	5
type diabetic	5
metabolic stress	5
human cancers	5
virus reduction	5
extracellular rna	5
therapeutic tool	5
adult respiratory	5
evs collected	5
ii iii	5
purification steps	5
evs associated	5
higher protein	5
hemorrhagic fever	5
intravenous immunoglobulins	5
iodixanol gradient	5
clinical benefit	5
chronic cd	5
samples using	5
spectral bands	5
bis zu	5
ductal adenocarcinoma	5
validation experiments	5
small volumes	5
may need	5
blast crisis	5
first days	5
thomas jefferson	5
small particles	5