trigram

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trigram	frequency
as well as	255
of convalescent plasma	214
the presence of	169
in patients with	166
the use of	143
nanoparticle tracking analysis	127
convalescent plasma therapy	118
in order to	114
in this study	108
the development of	106
the treatment of	105
were isolated from	104
evs were isolated	97
of extracellular vesicles	93
the role of	84
the effect of	82
was used to	78
one of the	77
transmission electron microscopy	75
due to the	74
for the treatment	71
been shown to	71
of patients with	70
the expression of	68
in the presence	68
of this study	66
the effects of	65
derived extracellular vesicles	64
were used to	64
this study was	64
cd and cd	64
the number of	62
use of convalescent	61
severe acute respiratory	61
we found that	60
size exclusion chromatography	58
to determine the	58
is associated with	55
patients with covid	55
found to be	54
can be used	53
based on the	53
the aim of	53
acute respiratory syndrome	52
the risk of	51
study was to	51
by nanoparticle tracking	50
were isolated by	49
there is a	48
with convalescent plasma	48
in response to	47
of evs in	46
be used to	46
small extracellular vesicles	46
has been shown	45
changes in the	45
evs derived from	44
patients with severe	43
convalescent plasma for	43
was found to	43
was supported by	43
were analysed by	42
critically ill patients	41
to investigate the	41
the incidence of	41
is the most	41
the concentration of	40
to evaluate the	40
the absence of	40
were able to	40
an increase in	39
a variety of	39
compared to the	39
of the disease	39
the detection of	38
mesenchymal stem cells	38
in the plasma	38
according to the	38
the release of	38
of the plasma	38
convalescent plasma in	38
supported by the	37
were characterized by	37
involved in the	37
associated with the	37
in vitro and	37
low molecular weight	37
of the most	37
red blood cells	37
were treated with	37
to be a	37
it has been	37
in comparison to	36
of evs from	36
this work was	36
plasma therapy in	36
role in the	36
analysis of the	35
in addition to	35
on the surface	35
activation of the	35
aim of this	35
the efficacy of	35
has not been	35
convalescent plasma transfusion	35
and in vivo	35
by western blot	34
the surface of	34
by flow cytometry	34
cells treated with	34
the potential to	34
treatment of covid	34
the time of	34
the need for	34
the production of	33
the pathogenesis of	33
a total of	33
a combination of	33
the ability of	33
patients treated with	33
respiratory syndrome coronavirus	33
was assessed by	32
source plasma donation	32
the lack of	32
blood samples were	32
and western blot	32
have shown that	31
a role in	31
to assess the	31
understanding of the	31
none of the	31
fresh frozen plasma	31
there was no	31
activated protein c	31
in contrast to	30
for the first	30
associated with a	30
the activation of	30
of the patients	30
in the absence	30
when compared to	30
therapy for covid	29
the present study	29
as compared to	29
shown to be	29
extracellular vesicles from	29
to study the	29
at the time	29
have been shown	29
well as the	29
the identification of	28
was measured by	28
the formation of	28
that can be	28
exosomes derived from	28
we investigated the	28
the results of	28
the majority of	28
the influence of	28
the united states	27
the importance of	27
work was supported	27
is one of	27
the levels of	27
convalescent plasma treatment	27
be used as	27
breast cancer patients	27
in terms of	27
the plasma of	27
the most common	27
thrombotic thrombocytopenic purpura	27
a number of	27
evs isolated from	27
the first time	27
important role in	26
plasma protein binding	26
convalescent plasma and	26
respiratory distress syndrome	26
there is no	26
may not be	26
are known to	26
the context of	26
an important role	26
due to their	26
isolated from the	26
vitro and in	26
there was a	26
the end of	26
from patients with	26
of plasma proteins	25
was associated with	25
used as a	25
the mechanism of	25
suggest that the	25
in the ev	25
were isolated using	25
most of the	25
was used for	25
were found to	25
in the blood	25
barriers and enablers	24
present in the	24
exosomes were isolated	24
was performed to	24
the convalescent plasma	24
and flow cytometry	24
and western blotting	24
in the treatment	24
and in the	24
plasma therapy for	24
therapeutic plasma exchange	24
were detected in	23
part of the	23
data suggest that	23
are associated with	23
an increase of	23
the factor v	23
we show that	23
used for the	23
detected in the	23
was confirmed by	23
with respect to	23
contribute to the	23
extracellular vesicles in	23
as a potential	23
were used for	23
resulted in a	22
in the pathogenesis	22
in the context	22
be used for	22
ill patients with	22
was performed using	22
and characterized by	22
to develop a	22
in the united	22
was determined by	22
the amount of	22
should be considered	22
compared to control	22
cancer cell lines	22
development of a	22
obtained from the	22
flow cytometry and	22
analysis was performed	21
a range of	21
in recipient cells	21
plasma as a	21
in our study	21
be associated with	21
are present in	21
seems to be	21
of the coagulation	21
to understand the	21
the safety of	21
von willebrand factor	21
in the field	21
such as the	21
on the other	21
for patients with	21
acute respiratory distress	21
safety and efficacy	21
isolation of evs	21
early detection of	21
in human plasma	21
efficacy of convalescent	20
the tumour microenvironment	20
has been reported	20
mesenchymal stem cell	20
appears to be	20
in the present	20
in plasma and	20
we hypothesized that	20
were determined by	20
isolated from plasma	20
the same time	20
factor v leiden	20
treatment of severe	20
we have developed	20
convalescent plasma is	20
evs were characterized	20
of these patients	20
the level of	20
known to be	20
we demonstrate that	20
results indicate that	20
from cell culture	20
may be a	20
the combination of	20
in the same	20
the case of	20
the most abundant	20
isolated by ultracentrifugation	20
we were able	20
of the evs	20
for the detection	20
has been used	20
the potential of	20
the range of	20
in prostate cancer	20
well as in	19
by differential centrifugation	19
to identify the	19
was analysed by	19
in the range	19
because of the	19
and treatment of	19
of plasma exchange	19
the diagnosis of	19
as a result	19
we developed a	19
convalescent plasma as	19
as a novel	19
at the end	19
before and after	19
have been reported	19
we have previously	19
the isolation of	19
resistive pulse sensing	19
which can be	19
proteins in the	19
of evs and	19
it can be	19
some of the	19
and transmission electron	19
effectiveness of convalescent	19
and mass spectrometry	19
play a role	19
evs released by	19
the other hand	19
evs in the	19
the field of	19
middle east respiratory	19
could not be	19
in severe covid	19
is characterized by	19
were obtained from	19
size distribution of	19
as biomarkers for	19
different types of	19
increased levels of	19
in the case	19
have not been	19
data show that	18
electron microscopy and	18
of human plasma	18
we aim to	18
can also be	18
observed in the	18
of the study	18
the activity of	18
a wide range	18
be involved in	18
have been described	18
their ability to	18
exosomes isolated from	18
the onset of	18
we observed that	18
may contribute to	18
and size exclusion	18
is supported by	18
that convalescent plasma	18
were incubated with	18
human umbilical vein	18
and can be	18
wide range of	18
cell lung cancer	18
expression of cd	18
collected from patients	18
the university of	18
the study was	18
used in the	18
of the ev	18
patients and healthy	18
western blot analysis	18
differences in the	18
at room temperature	18
in plasma of	17
proteins that are	17
plasma for fractionation	17
added to the	17
cell lines were	17
neutralizing antibody titers	17
play an important	17
in combination with	17
and nanoparticle tracking	17
were observed in	17
of severe acute	17
p and mir	17
this study is	17
and size distribution	17
the possibility of	17
and safety of	17
a result of	17
were cultured in	17
we aimed to	17
were found in	17
showed that the	17
approved by the	17
patients compared to	17
results suggest that	17
we hypothesize that	17
red blood cell	17
multiple myeloma in	17
to that of	17
were measured by	17
high levels of	17
is important to	17
smooth muscle cells	17
the course of	17
are involved in	17
depends on the	17
serve as a	17
were collected from	17
the involvement of	17
cell culture media	17
in the last	17
with or without	17
by differential ultracentrifugation	17
was performed on	17
the impact of	17
of evs were	17
to examine the	17
we conclude that	17
found in the	17
during the first	17
patients with acute	16
we report on	16
the patient was	16
east respiratory syndrome	16
a subset of	16
in breast cancer	16
plasma amino acid	16
size and concentration	16
a history of	16
revised eligibility criteria	16
are able to	16
traumatic brain injury	16
convalescent plasma to	16
the purpose of	16
was observed in	16
circulating tumor dna	16
used to determine	16
tangential flow filtration	16
the analysis of	16
the application of	16
at the same	16
may lead to	16
to measure the	16
in der regel	16
in these patients	16
by mass spectrometry	16
correlated with the	16
to be the	16
and characterization of	16
risk factor for	16
as a therapeutic	16
deep vein thrombosis	16
of whole blood	16
men who have	16
with and without	16
evs from the	16
of critically ill	16
riboflavin and uv	16
a set of	16
admitted to the	16
were performed to	16
have developed a	16
sex with men	16
between the two	16
to this end	16
umbilical vein endothelial	16
from the plasma	16
of the virus	16
is based on	16
small cell lung	16
was performed by	16
we demonstrated that	16
a group of	16
is the first	16
to determine whether	16
by transmission electron	16
due to a	15
plasma should be	15
and expression of	15
in both the	15
the ability to	15
that may be	15
was obtained from	15
the rate of	15
d and d	15
institutes of health	15
to the development	15
negative breast cancer	15
were associated with	15
plasma samples were	15
in all patients	15
in the tumour	15
national institutes of	15
the discovery of	15
in whole blood	15
findings suggest that	15
tracking analysis and	15
responsible for the	15
related to the	15
of evs was	15
the pathophysiology of	15
for early detection	15
used to identify	15
in the first	15
central nervous system	15
the addition of	15
derived from the	15
the goal of	15
increase in the	15
was used as	15
to reduce the	15
increased expression of	15
and enablers to	15
the transfer of	15
the prevalence of	15
plasma has been	15
for use in	15
an in vitro	15
has also been	15
it is important	15
in the brain	15
the progression of	15
the cell surface	15
hav ig titers	15
as a model	15
the evaluation of	15
of extracellular vesicle	15
of lyophilized plasma	15
different isolation methods	14
ebola virus disease	14
for the development	14
the immune system	14
was collected from	14
members of the	14
morbidity and mortality	14
food and drug	14
of these agents	14
proteomic analysis of	14
severe or life	14
a significant increase	14
by the national	14
of the cats	14
nature of the	14
differential ultracentrifugation and	14
results of the	14
leading to the	14
characterized by nanoparticle	14
in this context	14
that have been	14
plasma for the	14
the age of	14
efficacy and safety	14
the effectiveness of	14
for min at	14
in the early	14
concentration of the	14
were enriched in	14
acute lung injury	14
have demonstrated that	14
was detected in	14
and uv light	14
the quality of	14
compared to controls	14
for ev isolation	14
a cohort of	14
breast cancer cells	14
in of cases	14
limit of detection	14
in the usa	14
and analysed by	14
the process of	14
a lack of	14
show that the	14
plasma samples from	14
of these cells	14
outer membrane vesicles	14
need to be	14
from the same	14
has been demonstrated	14
in convalescent plasma	14
expression of the	14
previously shown that	14
in case of	14
mesenchymal stromal cells	14
treated with convalescent	14
were assessed by	14
in the majority	14
ml of plasma	14
no significant differences	14
of exosomes in	14
the frequency of	14
with multiple myeloma	14
risk factors for	14
the concentrations of	14
a key role	14
well as for	14
is dependent on	14
a population of	14
of prostate cancer	14
from human plasma	14
were exposed to	14
a decrease in	14
in relation to	14
key role in	14
the normal range	14
the control group	14
circulating extracellular vesicles	14
a patient with	13
significant increase in	13
of plasma protein	13
the bone marrow	13
included in the	13
of breast cancer	13
of multiple myeloma	13
were identified by	13
the value of	13
of plasma for	13
world health organization	13
better understanding of	13
elevated levels of	13
demonstrated that the	13
at least one	13
the safety and	13
the utility of	13
in the evs	13
of the first	13
been associated with	13
is expected to	13
was funded by	13
a panel of	13
blood was collected	13
the study of	13
our understanding of	13
using nanoparticle tracking	13
in which the	13
for breast cancer	13
thought to be	13
can lead to	13
ev biogenesis and	13
school of medicine	13
plasma levels of	13
and drug administration	13
that extracellular vesicles	13
all rights reserved	13
it is not	13
a series of	13
of the cell	13
of factor viii	13
it is known	13
in critically ill	13
the function of	13
to compare the	13
for convalescent plasma	13
and patients with	13
and healthy controls	13
has been described	13
the viral safety	13
in a large	13
and electron microscopy	13
characterization of evs	13
of the protein	13
dynamic light scattering	13
were subjected to	13
in vivo and	13
of the human	13
a year old	13
there were no	13
were performed on	13
activity of the	13
properties of the	13
using convalescent plasma	13
from plasma of	13
diseases such as	13
is an important	13
but not in	13
light chain proteinuria	13
was evaluated by	13
the molecular mechanisms	13
is essential for	13
have previously shown	13
change in the	13
protein binding of	13
safe and effective	13
both in vitro	13
e particles ml	13
thermo fisher scientific	13
the uptake of	13
and efficacy of	13
were quantified by	13
convalescent plasma with	13
populations of evs	13
all of the	13
and evs were	13
may serve as	13
were confirmed by	13
the relationship between	13
and in vitro	13
mechanism of action	13
the assessment of	13
depending on the	13
to characterize the	12
not associated with	12
we found a	12
by western blotting	12
safety of the	12
but it is	12
was able to	12
head and neck	12
used to treat	12
the characterization of	12
the spanish flu	12
the plasma membrane	12
who have sex	12
human immunodeficiency virus	12
consistent with the	12
to have a	12
goal of this	12
have been developed	12
has to be	12
in both groups	12
characterization of the	12
molecular weight heparin	12
these results suggest	12
randomized controlled trial	12
was to determine	12
an in vivo	12
the evs were	12
the secretion of	12
density gradient centrifugation	12
over the last	12
cell of origin	12
plasma amino acids	12
prostate cancer cells	12
of blood products	12
have sex with	12
there is an	12
in all cases	12
according to their	12
mechanism by which	12
acute myocardial infarction	12
of the proteins	12
in sars patients	12
after convalescent plasma	12
our data suggest	12
by ultracentrifugation and	12
we are currently	12
of neutralizing antibodies	12
protein and rna	12
purpose of this	12
was performed in	12
samples were drawn	12
in the literature	12
in the us	12
convalescent plasma should	12
the manufacture of	12
have also been	12
leading cause of	12
in the s	12
treatment of critically	12
can be detected	12
it is possible	12
the type of	12
have the potential	12
were differentially expressed	12
concentration and size	12
plasma for covid	12
of evs by	12
intensive care unit	12
a period of	12
plasma of patients	12
we have shown	12
viral safety of	12
using flow cytometry	12
for early diagnosis	12
expression levels of	12
of the total	12
the induction of	12
each of the	12
could be a	12
in the study	12
significantly higher in	12
and may be	12
studies suggest that	12
studies have shown	12
lead to a	12
this study we	12
in a cat	12
have been identified	12
b university of	12
tumour growth and	12
levels of mir	12
csf and plasma	12
and nucleic acids	12
number of evs	12
to isolate and	12
the percentage of	12
convalescent plasma infusion	12
followed by a	12
mechanisms by which	12
did not show	12
in the development	12
the ratio of	12
the blood of	12
patients with a	12
was carried out	12
this work is	12
to be of	12
cancer cells and	12
essential amino acid	12
to be associated	12
increased risk of	12
than that of	12
the collection of	12
has the potential	12
therapy in severe	11
and density gradient	11
study is to	11
higher levels of	11
or absence of	11
to patients with	11
is also a	11
as measured by	11
polymerase chain reaction	11
associated with evs	11
prolongation of the	11
to establish the	11
the coagulation system	11
the basis of	11
the presence or	11
in the future	11
plasma in a	11
of evs to	11
a reduction in	11
in vivo studies	11
was assessed using	11
of endothelial cells	11
results show that	11
the limit of	11
a pilot study	11
in this work	11
sevs isolated from	11
which was not	11
epidermal growth factor	11
of red blood	11
plasma to treat	11
likely to be	11
biomarkers for early	11
use of a	11
the mechanisms of	11
concentration of evs	11
as determined by	11
were analysed using	11
was to evaluate	11
experiments were performed	11
vein endothelial cells	11
has been developed	11
potential role of	11
was treated with	11
is present in	11
a crucial role	11
were positive for	11
patients in the	11
correlation between the	11
for the isolation	11
l cam evs	11
proteins such as	11
the beginning of	11
convalescent plasma was	11
in a study	11
for diagnostic and	11
mortality in patients	11
evs from plasma	11
aim of our	11
the hypothesis that	11
were elevated in	11
physiological and pathological	11
with regard to	11
to test the	11
impact on the	11
and hemorrhagic shock	11
evs can be	11
donor centre staff	11
the regulation of	11
been used to	11
be due to	11
reduction in the	11
of colorectal cancer	11
levels of the	11
from the national	11
state of the	11
is known to	11
resulting in a	11
we examined the	11
national cancer institute	11
serious adverse events	11
the severity of	11
was found in	11
for disease control	11
triple negative breast	11
associated with increased	11
the association between	11
g for min	11
the most frequent	11
extracellular vesicles introduction	11
of the viral	11
in a single	11
effects of convalescent	11
on the basis	11
was measured using	11
for up to	11
was to investigate	11
the fact that	11
feline infectious peritonitis	11
we used the	11
vascular smooth muscle	11
cells in the	11
evs and their	11
we showed that	11
treatment with convalescent	11
this is the	11
of growth factors	11
role of evs	11
mutation in the	11
cell lines and	11
were compared with	11
we present a	11
assessment of the	11
from whole blood	11
the design of	11
may play a	11
in asthma and	11
to our knowledge	11
in an in	11
presence or absence	11
the purity of	11
more than of	11
whole blood donation	11
evs were analysed	11
the plasma protein	11
plasma exchange is	10
the in vitro	10
was approved by	10
by electron microscopy	10
the management of	10
orders of magnitude	10
and it is	10
yet to be	10
of cancer cells	10
that of the	10
which could be	10
distribution of evs	10
is known that	10
end of the	10
effect on the	10
is thought to	10
to cross the	10
plasma therapy has	10
compared to those	10
breast cancer cell	10
a university of	10
the blood supply	10
the amino acids	10
to increase the	10
content of the	10
was isolated from	10
particles in the	10
a and b	10
partial thromboplastin time	10
plasma therapy on	10
treated with prostanoids	10
to establish a	10
was shown to	10
evs in a	10
effect of the	10
by size exclusion	10
study aimed to	10
recovered from covid	10
a decrease of	10
are needed to	10
were negative for	10
the general population	10
analysis revealed that	10
patients compared with	10
insights into the	10
in accordance with	10
of coronavirus disease	10
the patients with	10
feline multiple myeloma	10
hospitalized patients with	10
in the past	10
convalescent plasma has	10
as part of	10
to explore the	10
group of patients	10
stages of the	10
this study aimed	10
for the presence	10
isolated evs from	10
factors such as	10
density gradient ultracentrifugation	10
nm in diameter	10
factor v gene	10
to activated protein	10
by means of	10
compared with the	10
evs compared to	10
we observed a	10
the cells were	10
and concentration of	10
evs released from	10
isolation and characterization	10
a case report	10
cancer cells in	10
have been used	10
proved to be	10
patients suffering from	10
have been found	10
evs secreted by	10
in comparison with	10
in the patient	10
of the blood	10
is able to	10
as a biomarker	10
data suggests that	10
evs produced by	10
samples were collected	10
led to the	10
patients and controls	10
used to assess	10
it is also	10
treated with np	10
status of the	10
treatment of plasma	10
of the covid	10
studies on the	10
to improve the	10
be detected in	10
on their surface	10
this study will	10
derived evs were	10
plasma and serum	10
caused by a	10
associated with an	10
effects of the	10
major depressive disorder	10
is caused by	10
crucial role in	10
in the group	10
lead to the	10
convalescent blood products	10
of our study	10
cats in this	10
found that the	10
for the identification	10
the national institute	10
the sensitivity of	10
to optimize the	10
to the icu	10
the decrease of	10
in the protein	10
early diagnosis of	10
in recent years	10
a study of	10
e nm ss	10
myeloma in a	10
similar to the	10
results in a	10
university of pennsylvania	10
the degree of	10
of plasma and	10
the extent of	10
the inhibition of	10
to be more	10
from the blood	10
plasma and the	10
compared with controls	10
the capacity of	10
analysis of evs	10
the central nervous	10
cells were treated	10
no significant difference	10
plasminogen activator inhibitor	10
based on a	10
surface of the	10
it should be	10
of bone marrow	10
a pivotal role	10
sensitivity and specificity	10
the airway lumen	10
whole blood or	10
of up to	10
diagnostic and therapeutic	10
the airway mucosa	10
shown to have	10
expression of mir	10
transfusion of convalescent	10
of intercellular communication	10
is poorly understood	10
due to its	10
of the us	10
be applied to	10
and has been	10
plasma collected from	10
were labelled with	10
treatment for covid	10
have to be	10
and subjected to	10
can serve as	10
effect of convalescent	10
of cancer patients	10
was admitted to	10
function of the	10
with the same	10
luminal entry of	10
it is a	10
the administration of	10
convalescent whole blood	10
nm in size	10
could be used	10
for the production	10
we have identified	10
hepatitis c virus	10
cells of the	10
the correlation between	10
for detection of	10
with the use	9
were evaluated by	9
serum and plasma	9
caused by the	9
to be used	9
results showed that	9
antibody levels in	9
with severe or	9
and the development	9
of evs is	9
blood cells and	9
for the collection	9
by grants from	9
in part by	9
cells in vitro	9
therapeutic potential of	9
was no significant	9
characterized by a	9
small rna sequencing	9
inactivation and removal	9
proteins were identified	9
the characteristics of	9
data demonstrate that	9
there has been	9
cancer cell line	9
as biomarkers of	9
were obtained by	9
on extracellular vesicles	9
analysis of ev	9
used as the	9
a role for	9
our data demonstrate	9
significant difference in	9
at c for	9
differentially expressed proteins	9
mechanisms of action	9
be present in	9
in lung cancer	9
we report a	9
little is known	9
funded by the	9
a swine model	9
rna and protein	9
that it is	9
of the dna	9
components of the	9
treatment of patients	9
in intercellular communication	9
could be detected	9
the us fda	9
theoretical domains framework	9
high expression of	9
the spread of	9
years of age	9
of exosomes from	9
and purity of	9
protein c and	9
structure of the	9
was based on	9
com ccm f	9
was designed to	9
in plasma samples	9
significant differences in	9
the volume of	9
that there is	9
is achieved by	9
be a useful	9
sera option for	9
leads to a	9
induced pluripotent stem	9
a model of	9
of the manuscript	9
the intensive care	9
blood or plasma	9
the removal of	9
information on the	9
these findings suggest	9
isolated from human	9
inhibition of the	9
the copyright holder	9
compared to healthy	9
in cerebrospinal fluid	9
plasma exudation in	9
to be an	9
to analyse the	9
plasma samples of	9
that could be	9
prostate cancer patients	9
evs were purified	9
cancer patients and	9
to convalescent plasma	9
role of the	9
in evs from	9
was added to	9
for ev detection	9
isolated by differential	9
demonstrate that the	9
the convalescent sera	9
use of plasma	9
to target cells	9
with severe acute	9
to better understand	9
extracellular vesicles as	9
within the first	9
of platelet activation	9
is a major	9
as mediators of	9
our study was	9
convalescent plasma donors	9
detection of the	9
the difference in	9
a multitude of	9
proteins involved in	9
is consistent with	9
not yet been	9
pluripotent stem cells	9
in hong kong	9
these data suggest	9
are likely to	9
pivotal role in	9
were performed in	9
for containing covid	9
influenced by the	9
is a e	9
as a possible	9
by the presence	9
in regenerative medicine	9
been implicated in	9
have been implicated	9
first time that	9
as in the	9
is possible to	9
do not have	9
of the clot	9
growth factor receptor	9
western blotting and	9
used to analyse	9
in extracellular vesicles	9
for this study	9
option for containing	9
of amino acids	9
serve as biomarkers	9
to treat covid	9
cell communication and	9
for factor v	9
and protein s	9
been found to	9
exosomes and liposomes	9
use of the	9
and stored at	9
may be useful	9
we describe a	9
been shown that	9
similar results were	9
performed in the	9
the prevention and	9
are shown in	9
risk of bleeding	9
the isolated evs	9
and activation of	9
reduced mortality in	9
as potential biomarkers	9
is regulated by	9
convalescent sera option	9
be useful for	9
the site of	9
west nile virus	9
gene expression analysis	9
using differential ultracentrifugation	9
markers cd and	9
the interaction between	9
of evs as	9
be caused by	9
determine the effect	9
from conditioned media	9
transfusion of covid	9
can result in	9
are used to	9
plasma proteins in	9
were used as	9
release of evs	9
this research was	9
imaging flow cytometry	9
a and mir	9
health and disease	9
lung cancer patients	9
therapy in sars	9
can be obtained	9
plasma in covid	9
factor v mutation	9
the recovery of	9
comparison of the	9
developed a novel	9
such as cd	9
prostate cancer cell	9
from cancer cells	9
innate immune response	9
is important for	9
to elucidate the	9
stem cell evs	9
potential biomarkers for	9
dependent on the	9
the potential role	9
study was supported	9
t cell activation	9
their role in	9
detection of cancer	9
particle size and	9
is known about	9
in the progression	9
in the preparation	9
is a key	9
taken up by	9
the last years	9
to ensure that	9
quantified by nanoparticle	9
were measured in	9
than of the	9
aim is to	9
by addition of	9
antibody responses to	9
related acute lung	9
samples were obtained	9
challenging due to	9
presence of a	9
in the extracellular	9
responses to sars	9
plasma can be	9
analysed using a	9
b and c	9
the implementation of	9
presence of ev	9
various types of	9
a risk of	9
the concentration and	9
and could be	9
in a patient	9
role in cell	9
in a dose	9
a e nm	9
sevs were isolated	9
had to be	9
the establishment of	9
with a high	9
was induced by	9
induced platelet aggregation	9
supplemental digital content	9
were purified from	9
because of its	9
the contribution of	9
cross the blood	8
expression of genes	8
and at the	8
cells were incubated	8
differentially expressed mirnas	8
methods for the	8
addition to the	8
their capacity to	8
comparable to the	8
into the airway	8
human blood plasma	8
and quantification of	8
used to detect	8
extracellular vesicles were	8
associated with plasma	8
provided by the	8
have been detected	8
difference in the	8
to be determined	8
ev isolation methods	8
been found in	8
amyotrophic lateral sclerosis	8
studies have demonstrated	8
it is well	8
would like to	8
patients with metastatic	8
systematic review and	8
recent studies have	8
microscopy and western	8
the cats in	8
should be used	8
no effect on	8
in vitro study	8
to the surface	8
evidence for an	8
to the control	8
diagnostic and prognostic	8
dna damage in	8
difference between the	8
on the cell	8
results were confirmed	8
clinical signs of	8
day mortality rate	8
clinical symptoms and	8
out of patients	8
derived evs in	8
and that the	8
is involved in	8
the reduction of	8
supported by a	8
in the bone	8
present in both	8
human plasma and	8
proteomic profile of	8
of these evs	8
our results indicate	8
correlated well with	8
study was designed	8
other amino acids	8
into account the	8
caprylic acid precipitation	8
showed an increased	8
play a pivotal	8
of the brain	8
a potential biomarker	8
in children with	8
in the clinical	8
no evidence of	8
by using a	8
is not available	8
plasma concentrations of	8
of inflammation and	8
cells and the	8
for this purpose	8
effects of evs	8
to address this	8
hepatitis a virus	8
extracellular vesicles and	8
expression in the	8
in a swine	8
central role in	8
be a promising	8
whole blood and	8
been reported to	8
the plasma amino	8
suggests that the	8
the differences in	8
were analysed for	8
the mechanisms by	8
in cells treated	8
was followed by	8
with coronavirus disease	8
of the amino	8
the result of	8
supported by grants	8
dna as a	8
of rab a	8
response to the	8
to the study	8
in vitro studies	8
of the vesicles	8
a rapid and	8
specificity of the	8
in plasma evs	8
our data show	8
is responsible for	8
in the lmwh	8
metastatic breast cancer	8
the most important	8
plasma of the	8
of human blood	8
and protein cargo	8
be considered for	8
assays were performed	8
ml of convalescent	8
quantitative and qualitative	8
expression level of	8
this article is	8
to the same	8
aim of the	8
data indicate that	8
isolated from conditioned	8
the purification of	8
which is a	8
expected to be	8
quality and safety	8
were present in	8
between and nm	8
be effective in	8
differential gene expression	8
and red blood	8
characterized according to	8
the first to	8
under these conditions	8
tunable resistive pulse	8
of cd and	8
western blot and	8
these results indicate	8
focus on the	8
cellular uptake of	8
of the treatment	8
determination of the	8
clinically normal and	8
of the whole	8
not fully understood	8
a better understanding	8
a major role	8
of amino acid	8
may also be	8
regulation of the	8
from plasma and	8
of particles in	8
positively correlated with	8
by nta and	8
randomized controlled trials	8
sars patients in	8
we found the	8
of activated protein	8
of soluble fibrin	8
total ev numbers	8
may be an	8
in the course	8
compared to that	8
dependent enhancement of	8
identified in the	8
who have recovered	8
respect to the	8
resistance to activated	8
results of this	8
cells were cultured	8
were identified in	8
tumor necrosis factor	8
were performed using	8
and function of	8
strategy for the	8
derived evs from	8
with a history	8
have been demonstrated	8
on the ev	8
national institute of	8
is upregulated in	8
scanning electron microscopy	8
patients recovered from	8
of more than	8
from healthy subjects	8
of therapeutic plasma	8
there are no	8
been detected in	8
and the number	8
of plasma evs	8
the inflammatory response	8
protein content of	8
is critical for	8
member of the	8
reduction of the	8
with severe covid	8
critically ill covid	8
is a lack	8
cause of cancer	8
decrease of the	8
a central role	8
of plasma products	8
plasma and platelet	8
aim was to	8
of the present	8
of exosomes and	8
hyperimmune immunoglobulin for	8
characteristics of the	8
have recovered from	8
on the presence	8
dna and rna	8
we demonstrate the	8
flow cytometry analysis	8
for in vivo	8
the supernatant was	8
for isolation of	8
for the prevention	8
to be present	8
growth and metastasis	8
proteomic profiling of	8
and extracellular vesicles	8
markers such as	8
the results were	8
from tumour cells	8
the understanding of	8
analysis showed that	8
with poor prognosis	8
rna was isolated	8
interest in the	8
isolated from cell	8
the changes in	8
after symptom onset	8
isolated evs were	8
the group of	8
incubated with the	8
we isolated evs	8
to contribute to	8
well as a	8
were collected and	8
determined by the	8
we report the	8
remains to be	8
large amounts of	8
to demonstrate the	8
suggested that the	8
result in a	8
of evs isolated	8
role in this	8
plasma is a	8
to the clinical	8
has been suggested	8
did not affect	8
is the author	8
prevention and treatment	8
a systematic review	8
of isolated evs	8
is likely to	8
volume of plasma	8
passive antibody therapy	8
a method to	8
be the most	8
animal model of	8
of the airway	8
appear to be	8
the content of	8
risk of transfusion	8
evs were collected	8
using size exclusion	8
the loss of	8
a review of	8
has been proposed	8
mass spectrometry and	8
the fibrinolytic system	8
of evs released	8
the availability of	8
the inactivation of	8
to provide a	8
in the use	8
well suited for	8
of which are	8
induced oxidative stress	8
were separated from	8
good manufacturing practices	8
are derived from	8
in the world	8
and their cargo	8
efficacy of the	8
subpopulations of evs	8
hepatitis b virus	8
evs resulted in	8
any of the	8
its ability to	8
may be involved	8
have been proposed	8
log pfu ml	8
contrast to the	8
as a promising	8
we compared the	8
the acute phase	8
to source plasma	8
lack of a	8
multiple organ failure	8
protein in the	8
comparison to the	8
canadian blood services	8
of l cam	8
is a potent	8
of factor v	8
of the two	8
used to isolate	8
patients in hong	8
the determination of	8
in vivo experiments	8
of plasma in	8
stage of the	8
method for the	8
the world health	8
f viii concentrate	8
showed an increase	8
of mesenchymal stem	8
patients who have	8
here we report	7
in vivo model	7
in the population	7
of a novel	7
increase of the	7
in plasma derived	7
differentially expressed in	7
evs from human	7
proof of concept	7
therapy has been	7
evs were enriched	7
of the underlying	7
derived evs and	7
and the lack	7
had sex with	7
of the factor	7
were purified by	7
after the onset	7
than those of	7
in agreement with	7
human induced pluripotent	7
of a specific	7
high incidence of	7
this effect was	7
of the aptt	7
circulating levels of	7
a retrospective study	7
of blood coagulation	7
the results obtained	7
committee of the	7
for cancer detection	7
into the blood	7
are released by	7
the efficacy and	7
its role in	7
in the number	7
the theoretical domains	7
the most potent	7
was defined as	7
released by the	7
the preprint in	7
have investigated the	7
study showed that	7
up to days	7
the l cam	7
of the normal	7
it is still	7
medical research council	7
in our laboratory	7
directly from the	7
prior to the	7
plasma extracellular vesicles	7
clinical and laboratory	7
by measuring the	7
proteins associated with	7
may be the	7
clinical use of	7
up to of	7
to investigate whether	7
in the other	7
potential of evs	7
in healthy volunteers	7
was performed with	7
the extracellular vesicles	7
more likely to	7
abundant proteins in	7
system for the	7
bound to the	7
activity in the	7
treated with a	7
clinical features of	7
antibody titers in	7
compared with healthy	7
to isolate evs	7
report on a	7
to be safe	7
injected into the	7
have emerged as	7
supported in part	7
of this disease	7
in two covid	7
we have investigated	7
derived small extracellular	7
patients have been	7
the upregulation of	7
the cell of	7
of cats with	7
can be found	7
not show any	7
were analysed in	7
we sought to	7
the time course	7
activation of coagulation	7
of the rna	7
we studied the	7
in clinical practice	7
evs were used	7
rbd and anti	7
studies are needed	7
the potential for	7
the delivery of	7
not affected by	7
of the three	7
in the design	7
based liquid biopsy	7
to detect evs	7
among the most	7
one or more	7
cell viability and	7
for treatment of	7
cs sevs group	7
use of proteomic	7
into extracellular vesicles	7
was noted in	7
been able to	7
normal and fip	7
patients and methods	7
ev were isolated	7
for the use	7
removed from the	7
both in the	7
be able to	7
vesicles in the	7
it would be	7
is a promising	7
diabetes and cancer	7
the interaction of	7
the separation of	7
surface expression of	7
from different sources	7
who has granted	7
of the primary	7
reported that the	7
to play a	7
the relevance of	7
to develop an	7
of plasma therapy	7
circulating micrornas as	7
ingenuity pathway analysis	7
university school of	7
platelet rich plasma	7
future studies will	7
on the use	7
the change in	7
to determine if	7
was higher in	7
may be associated	7
depend on the	7
for prostate cancer	7
the mechanism by	7
with acute respiratory	7
the cause of	7
predictive value of	7
expression of pro	7
patients who had	7
the plasma and	7
the isolation and	7
it was found	7
vivo and in	7
enablers to source	7
communication in the	7
role in cancer	7
in all the	7
the appearance of	7
the author funder	7
the prognosis of	7
in each group	7
of healthy individuals	7
the evs from	7
is used for	7
effects of these	7
also be used	7
not well understood	7
the cell membrane	7
is well suited	7
development of an	7
were employed to	7
understand the role	7
for extracellular vesicle	7
used to manufacture	7
in vivo in	7
evs have been	7
that has been	7
patients with liver	7
be explained by	7
of evs with	7
were measured using	7
of evs produced	7
as evidenced by	7
isolate and characterize	7
side effects of	7
in the human	7
linked immunosorbent assay	7
of platelets and	7
of the immune	7
as demonstrated by	7
multiple myeloma is	7
to confirm the	7
been described as	7
were added to	7
to characterize evs	7
should not be	7
no difference in	7
as a consequence	7
to the hospital	7
recovered from the	7
in most cases	7
evs was performed	7
reduced in the	7
were used in	7
isolated using differential	7
able to isolate	7
were characterized using	7
performed to determine	7
of cells and	7
high degree of	7
in a recent	7
of evs derived	7
immune response and	7
a marker of	7
is the main	7
be useful in	7
donors who have	7
of circulating evs	7
of the research	7
for lung cancer	7
convalescent plasma or	7
we previously showed	7
and endothelial cells	7
preprint in perpetuity	7
the total protein	7
viral reduction treatments	7
received convalescent plasma	7
majority of patients	7
to display the	7
program of the	7
and hours after	7
the mayo clinic	7
in new york	7
in of the	7
distress syndrome in	7
of small evs	7
analysed by nanoparticle	7
of at least	7
to define the	7
cell derived evs	7
we did not	7
the feasibility of	7
present in plasma	7
in peripheral blood	7
is used to	7
leakage of plasma	7
molecular weight proteins	7
levels in the	7
our results demonstrate	7
patients from controls	7
a poor prognosis	7
is critical to	7
not certified by	7
the transfusion of	7
and compared to	7
evs was confirmed	7
safety indicators of	7
cohort of patients	7
us food and	7
lower than those	7
be attributed to	7
point mutation in	7
has granted medrxiv	7
written informed consent	7
in asthmatic airways	7
of in vitro	7
small ev secretion	7
times higher than	7
of these proteins	7
display the preprint	7
from healthy volunteers	7
vast majority of	7
a source of	7
to clarify the	7
cell culture supernatant	7
spanish influenza pneumonia	7
the leading cause	7
is a very	7
differential centrifugation and	7
plasma therapy is	7
there is also	7
to recipient cells	7
significant differences were	7
evs may be	7
is not associated	7
for single ev	7
viral inactivation and	7
and transfusion of	7
of the central	7
of stem cell	7
the increase in	7
the optimization of	7
amino acid concentrations	7
the internalization of	7
derived from mesenchymal	7
the generation of	7
a prevalence of	7
the most commonly	7
in a horse	7
in a cohort	7
expression profile of	7
belonging to the	7
a license to	7
insight into the	7
we have established	7
in csf and	7
in patients of	7
measured using a	7
a consequence of	7
research was supported	7
results in the	7
plasma evs were	7
purity of ev	7
development of novel	7
in the general	7
conditioned media of	7
of cancer cell	7
review of the	7
as it is	7
we have demonstrated	7
certified by peer	7
involved in cell	7
size distribution and	7
samples were then	7
we report that	7
the mortality rate	7
studies of the	7
will be used	7
the plasma samples	7
of platelets in	7
major role in	7
will be presented	7
be used in	7
the status of	7
contributed to the	7
of the platelet	7
from a single	7
ev release from	7
viral shedding and	7
is necessary for	7
smooth muscle cell	7
could provide a	7
our preliminary data	7
more than log	7
can be performed	7
patients diagnosed with	7
by peer review	7
of mefloquine in	7
in association with	7
studies showed that	7
exosomes have been	7
plasma in the	7
the abundance of	7
for h at	7
is a novel	7
is of great	7
were tested in	7
amplification of the	7
referred to as	7
new york city	7
time of the	7
rna and dna	7
ammonium sulphate precipitation	7
well with the	7
derived exosomes in	7
intranasal administration of	7
plasma and urine	7
the outcome of	7
different concentrations of	7
play a key	7
in body fluids	7
plasma of healthy	7
a protocol for	7
when compared with	7
therapy in two	7
report on the	7
in the circulation	7
we have recently	7
expressed in the	7
of small extracellular	7
the present work	7
and protein content	7
was incubated with	7
in plasma is	7
the enrichment of	7
plasma or serum	7
in intensive care	7
of exosome secretion	7
the size of	7
human umbilical cord	7
in the following	7
in presence of	7
detection and quantification	7
damage control resuscitation	7
evs x cells	7
animal models of	7
binding of mefloquine	7
of circulating extracellular	7
hemolytic uremic syndrome	7
order to avoid	7
as an alternative	7
response to therapy	7
was a significant	7
the two groups	7
newly born neurons	7
this suggests that	7
of fractionated products	7
detected in plasma	7
protein content was	7
early safety indicators	7
of conditioned medium	7
served as controls	7
and bone marrow	7
by the use	7
patients with hemophilia	7
at least days	7
patients and the	7
could lead to	7
or size exclusion	7
at least in	7
time course of	7
concentration of plasma	7
microfluidic resistive pulse	7
of the clinical	7
microvesicles and exosomes	7
identification of a	7
significantly elevated in	7
obtained from healthy	7
we evaluated the	7
the first step	7
is to develop	7
of using convalescent	7
coronary artery disease	7
medrxiv a license	7
at least two	7
level digraph analysis	7
to enhance the	7
should be performed	7
of exosomes isolated	7
are thought to	7
most abundant proteins	7
swine model of	7
our aim was	7
a risk factor	7
were significantly lower	7
high molecular weight	7
we are now	7
to an increased	7
principal component analysis	7
mechanisms involved in	7
in the normal	7
is well known	7
in clinical trials	7
t d and	7
we analysed the	7
the clotting time	7
for biomarker discovery	7
rna was extracted	7
significant reduction in	7
to meet the	7
as soon as	7
dna in plasma	7
been described in	7
granted medrxiv a	7
as opposed to	7
differential expression of	7
in platelet concentrates	7
an increased risk	7
determined by a	7
of less than	7
the kinetics of	7
indicate that the	7
on ev release	7
that evs from	7
were isolated and	7
of the host	7
higher in the	7
dmem supplemented with	7
a member of	7
squamous cell carcinoma	7
less than of	7
is necessary to	7
of mirna that	7
a significant reduction	7
did not change	7
evs as a	7
the response to	7
in the urine	7
the transmission of	7
for this reason	7
of hepatitis a	7
patients with sars	7
used as an	7
we also observed	7
concentrations of evs	7
important for the	7
has led to	7
completion of the	7
to quantify evs	7
in the control	7
described in the	7
has a high	7
the vast majority	7
no change in	7
on the platelet	7
analysed by western	7
significantly associated with	7
license to display	7
immunoglobulin for the	7
in the patients	7
by serial centrifugation	7
patients who were	7
to serve as	7
cell type specific	7
in health and	7
an activation of	7
should be avoided	7
are capable of	7
of the donor	7
was not certified	7
is believed to	7
early diagnosis and	7
the target cells	7
yon willebrand factor	7
of the results	7
correlation with the	7
our results showed	6
were observed for	6
data analysis was	6
amino acid minus	6
blood products for	6
evs from cell	6
to look for	6
national institute on	6
about of the	6
are based on	6
in bone marrow	6
is a critical	6
study was approved	6
differ in their	6
used to generate	6
density gradient purification	6
the duration of	6
final concentration of	6
and the effect	6
which may be	6
fold increase of	6
increase the risk	6
used to investigate	6
leading causes of	6
attributed to the	6
centers for disease	6
described to be	6
secreted from cells	6
suitable for the	6
patients showed a	6
this version posted	6
in factor v	6
in the two	6
cd t cell	6
large number of	6
days after symptom	6
the evs was	6
whole blood was	6
were tested for	6
vincristine and prednisone	6
wky and shr	6
was studied in	6
be responsible for	6
plasma of cancer	6
been developed for	6
in a time	6
and in a	6
to inhibit the	6
had a history	6
need for a	6
from mesenchymal stem	6
in another study	6
to isolate exosomes	6
focused on the	6
a significant difference	6
the state of	6
and on the	6
of the use	6
these studies suggest	6
characterization of extracellular	6
copyright holder for	6
is not a	6
a therapeutic strategy	6
transfusion transmission of	6
confirmed by the	6
activation of platelets	6
days after the	6
taken into account	6
were significantly higher	6
this kind of	6
antibody response in	6
for source plasma	6
in the airway	6
in expression of	6
decreased expression of	6
treated with the	6
flow cytometric analysis	6
cells and in	6
are emerging as	6
the samples were	6
holder for this	6
ranging from to	6
number of exosomes	6
acquired pneumonia and	6
article is protected	6
high level of	6
novel biomarkers for	6
of the individual	6
in cancer patients	6
decrease in the	6
the cellular uptake	6
microvascular endothelial cells	6
growth and invasion	6
venous thrombosis in	6
were included in	6
results of a	6
convalescent plasma use	6
of a large	6
we focus on	6
work was to	6
were collected by	6
in the host	6
but not with	6
the nature of	6
to maximize the	6
version posted june	6
been demonstrated to	6
cell free dna	6
similar to that	6
to validate the	6
the association of	6
cells may be	6
received funding from	6
resulted in the	6
inactivation of viruses	6
of thrombin generation	6
is concluded that	6
number and size	6
isolated from serum	6
plasma triacylglycerol and	6
analysis of plasma	6
over a period	6
both plasma and	6
of f viii	6
prove to be	6
in a d	6
of this mutation	6
ev surface marker	6
be one of	6
of severe covid	6
products such as	6
in the kidney	6
of coagulation factors	6
clinical efficacy of	6
range from to	6
of a scalable	6
on the contrary	6
evaluate the potential	6
during the same	6
of hiv infection	6
creative commons licence	6
the expression profile	6
we recently demonstrated	6
of liquid biopsy	6
cells of origin	6
using a combination	6
the early detection	6
review and exploratory	6
the current study	6
determined by elisa	6
endogenous dnase i	6
hrs after inhalation	6
and by the	6
cell adhesion molecule	6
with high sensitivity	6
and incubated for	6
shows that the	6
potential biomarker for	6
of the fibrinolytic	6
and hyperimmune immunoglobulin	6
significant decrease in	6
did not significantly	6
there are some	6
specificity and sensitivity	6
are exposed to	6
and convalescent plasma	6
public health emergency	6
values of the	6
can be applied	6
deficiency or over	6
for more than	6
at endothelial cells	6
products for spanish	6
release extracellular vesicles	6
will need to	6
pathways involved in	6
by amplification of	6
therapeutic strategy to	6
human convalescent plasma	6
ev isolation from	6
protected by copyright	6
evs were also	6
lyophilized plasma is	6
performed on the	6
not affect the	6
seem to be	6
for severe covid	6
a final concentration	6
ng ml and	6
represents a major	6
informed consent was	6
were prepared by	6
that exosomes derived	6
act as a	6
or presence of	6
of proteins were	6
the biogenesis of	6
the exosomes were	6
c for hours	6
sinai medical center	6
significantly increased in	6
affected by the	6
role of plasma	6
mi r exo	6
via extracellular vesicles	6
virus of the	6
was investigated by	6
a diagnosis of	6
widely used in	6
a case of	6
identification of the	6
respiratory infections of	6
randomized clinical trial	6
result in the	6
in cell culture	6
preparation and transfusion	6
yr cvd risk	6
a highly sensitive	6
differentially expressed between	6
by our team	6
vesicles from human	6
the recognition of	6
a matter of	6
one essential amino	6
the host and	6
samples were taken	6
and ultraviolet light	6
bone marrow derived	6
umbilical cord mesenchymal	6
changes in ev	6
was determined in	6
and the concentration	6
of blood transfusion	6
characterized by transmission	6
the proportion of	6
the first study	6
was present in	6
their effect on	6
protein composition of	6
stem cells and	6
goal was to	6
role in maintaining	6
of ev cargo	6
diagnosis and prognosis	6
derived from human	6
as a marker	6
diagnosis and treatment	6
platelet reactivity in	6
foetal bovine serum	6
the selection of	6
the composition of	6
the inhibitory effect	6
indicators of covid	6
to the cell	6
and cd were	6
this study demonstrates	6
patients with coronavirus	6
were performed with	6
performed using the	6
profiling of evs	6
in the lower	6
and the presence	6
we identified a	6
of infectious diseases	6
total evs were	6
we decided to	6
the occurrence of	6