bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
class i	2215
mhc class	1746
class ii	1223
immune response	754
dendritic cells	524
major histocompatibility	459
immune system	457
immune responses	436
histocompatibility complex	408
cell epitopes	397
amino acid	385
antigen presentation	379
i molecules	361
cell surface	350
cell receptor	321
amino acids	300
cell responses	286
mhc i	284
cd cd	262
mhc molecules	249
cell lines	243
virus infection	241
cell epitope	236
peripheral blood	226
bone marrow	225
gene expression	216
cell activation	214
i mhc	211
antigen processing	211
ii mhc	208
multiple sclerosis	196
specific cd	193
flow cytometry	192
nervous system	188
endoplasmic reticulum	188
hla class	183
cell response	183
cell line	179
cell clones	178
peptide binding	161
ii molecules	161
cell death	160
complex class	159
central nervous	158
type i	157
presenting cells	151
epitope prediction	150
binding affinity	150
cd cells	150
dna vaccine	145
infected cells	145
graft survival	144
viral infection	141
antigen expression	140
endothelial cells	138
nk cells	138
i expression	137
transgenic mice	134
innate immune	133
epithelial cells	133
adaptive immune	130
cell proliferation	128
influenza virus	128
immunodeficiency virus	125
tumor cells	123
necrosis factor	122
mhc ii	117
dengue virus	116
data suggest	116
cell types	115
viral infections	115
surface expression	115
significantly higher	114
may also	113
important role	112
high levels	112
transplant recipients	112
dendritic cell	110
dna vaccines	110
i antigen	109
vaccine design	108
human immunodeficiency	107
ng ml	107
cord uid	106
doc id	106
present study	105
cytokine production	105
tumor necrosis	104
monoclonal antibodies	104
lymph nodes	103
acute rejection	102
i alleles	101
deficient mice	98
cell recognition	96
binding peptides	93
natural killer	93
mast cells	93
nkt cells	93
antigen presenting	92
nk cell	92
population coverage	92
vaccine development	91
rhesus macaques	91
target cells	91
signal transduction	90
mhc antigen	90
virus type	89
virus replication	89
specific ctl	89
antibody response	88
immune cells	87
wild type	87
respiratory syndrome	87
er membrane	86
monoclonal antibody	85
results suggest	85
vaccinia virus	84
innate immunity	84
autoimmune diseases	83
like receptor	83
autoimmune disease	82
infectious diseases	81
previously described	81
cell receptors	80
adaptive immunity	80
viral proteins	79
i binding	79
inflammatory response	78
mrna expression	78
ctl response	78
i molecule	77
kidney transplant	77
herpes simplex	77
host immune	77
mononuclear cells	76
genetic diversity	76
cell repertoire	76
human papillomavirus	75
membrane protein	75
positive cells	74
performed using	74
ebola virus	74
heavy chain	73
basic protein	73
molecular mimicry	73
cell subsets	73
infected mice	73
mhc antigens	72
viral replication	72
hepatitis virus	71
myelin basic	71
host cell	71
adhesion molecules	71
ii binding	70
mhc binding	70
plasmid dna	70
protein sequences	70
acute respiratory	69
glial cells	69
ex vivo	69
effector cells	68
th cells	68
inkt cells	68
lymph node	68
stem cells	68
nitric oxide	68
protein expression	67
expressing cells	67
cells expressing	67
simplex virus	67
renal function	66
intracellular pathogens	66
ctl epitopes	66
human cytomegalovirus	66
cell population	66
mouse model	66
bl mice	65
bnp dams	65
mhc expression	65
ii alleles	65
i genes	65
transcription factor	65
antigen recognition	65
dependent manner	64
clinical trials	64
growth factor	64
liver transplantation	64
spleen cells	64
severe acute	64
mouse hepatitis	63
cell development	63
significantly lower	63
signal peptide	63
antibody responses	63
binding site	63
like receptors	62
may contribute	62
inflammatory cytokines	62
highly conserved	62
pg ml	61
ii expression	61
virus infections	61
neutralizing antibodies	61
graft function	60
drb alleles	60
sertoli cells	60
graft loss	60
ctl responses	60
cell populations	60
chronic rejection	59
mhc molecule	59
additional file	59
target cell	59
peptide vaccine	59
presentation pathway	59
antigenic peptides	59
ii antigen	58
previous studies	58
renal transplant	58
barr virus	58
molecular mechanisms	57
determine whether	57
ctl escape	57
human cd	57
salt bridge	57
low levels	57
binding prediction	56
infectious virus	56
human mhc	56
mg kg	56
disease virus	55
escape mutants	55
allograft rejection	55
viral antigens	55
cell differentiation	55
cells may	54
control group	54
based vaccine	54
kidney transplantation	54
recombinant protein	54
cellular immune	54
adhesion molecule	53
expression levels	53
rabies virus	53
cell function	53
apoptotic cells	53
rna viruses	53
data indicate	53
positive selection	52
viral rna	52
western blot	52
cell cycle	52
nipah virus	52
host cells	52
cd expression	52
synthetic peptides	51
specific immune	51
significantly reduced	51
protective immunity	51
results indicate	51
dna vaccination	51
cell type	51
plasma membrane	51
vg vd	50
animal models	50
immune surveillance	50
mg dl	50
bvd vaccinated	50
gene products	49
human leukocyte	49
vaccine candidates	49
subunit vaccines	49
least one	49
protein kinase	49
may play	49
protein sequence	49
i antigens	49
acid sequence	48
signaling pathways	48
helper cells	48
bat mhc	48
memory cd	48
long term	48
large number	48
autophagy proteins	48
mediated rejection	48
quality control	48
i heavy	48
stem cell	48
allergic encephalomyelitis	47
tlr ligands	47
experimental allergic	47
two different	47
also known	47
envelope protein	47
cells specific	47
allograft survival	47
immune epitope	46
sequence alignment	46
west nile	46
cd foxp	46
mhc complexes	46
mice immunized	46
central role	46
recent studies	46
transcription factors	46
ubiquitin ligase	45
mass spectrometry	45
montanide isa	45
heat shock	45
specific cytotoxic	45
gene delivery	45
leukocyte antigen	45
mast cell	45
first time	45
healthy controls	45
plasma cells	45
hla alleles	45
significantly increased	45
immune evasion	44
high affinity	44
previously shown	44
neutralizing antibody	44
ml min	44
serum creatinine	44
wide range	44
adoptive transfer	44
antigenic peptide	44
humoral immune	43
brain barrier	43
mice infected	43
proinflammatory cytokines	43
patient survival	43
cell mediated	42
analyzed using	42
vaccine candidate	42
cells express	42
protein synthesis	42
blood mononuclear	42
gene therapy	42
associated degradation	42
epitope database	42
surface molecules	42
endothelial cell	42
taken together	42
costimulatory molecules	42
cells within	42
microglial cells	42
mycobacterium tuberculosis	42
mediated immune	42
ii mrna	42
mhc genes	42
critical role	42
high level	42
peptide complexes	42
risk factors	42
even though	41
reverse vaccinology	41
family members	41
days post	41
syndrome coronavirus	41
rhesus macaque	41
binding motifs	41
two groups	41
crystal structure	41
type ii	41
producing cells	41
immunized mice	41
tg mice	41
viral peptides	41
chinese rhesus	41
molecular weight	41
antiviral immunity	40
specific antibodies	40
predicted epitopes	40
closely related	40
com scientificreports	40
i peptide	40
time points	40
sequence similarity	40
also observed	40
positional bias	40
hemorrhagic fever	40
increased expression	39
acid sequences	39
virus glycoprotein	39
results demonstrate	39
cell antigen	39
i ifn	39
mer peptides	39
immune recognition	39
based vaccines	39
disease progression	39
hiv infection	39
prediction methods	39
transplant patients	39
blood samples	38
data show	38
infectious agents	38
disulfide isomerase	38
germ cells	38
mycobacterium avium	38
genetic variation	38
peptide presentation	38
peptide loading	38
balancing selection	38
blot analysis	38
i presentation	38
differentially expressed	38
control groups	38
mhc complex	38
virus release	38
cell membrane	38
web server	38
different mhc	38
liver transplant	37
fc receptor	37
protein antigens	37
lymphocyte responses	37
results show	37
may lead	37
peptides derived	37
langerhans cells	37
dna constructs	37
cell immunity	37
gene product	37
tumor growth	37
cell clone	37
mediated immunity	37
fold increase	37
recognition receptors	37
molecular dynamics	37
crucial role	37
delivery systems	36
protective immune	36
transporter associated	36
knockout mice	36
immune cell	36
protein disulfide	36
time pcr	36
may provide	36
facs analysis	36
human hla	36
side effects	36
peptide sequences	36
molecular docking	36
significant increase	36
killer cells	36
invariant chain	36
chicken mhc	36
acid residues	36
chronic inflammatory	36
ii antigens	36
hla molecules	36
heavy chains	36
higher levels	36
healthy donors	35
key role	35
ko mice	35
sertoli cell	35
peptide ligands	35
sequence analysis	35
single amino	35
binding protein	35
stranded rna	35
draining lymph	35
significant difference	35
graft rejection	35
encephalitis virus	35
toxoplasma gondii	35
differential expression	35
membrane proteins	34
ii presentation	34
ii genes	34
genes involved	34
sendai virus	34
infected patients	34
synthetic peptide	34
cancer cells	34
express class	34
host defense	34
protein degradation	34
express mhc	34
highly immunogenic	34
measles virus	34
dtg mice	34
binding groove	34
significant differences	34
antibody production	34
cellular immunity	33
tissue culture	33
lymphocytic choriomeningitis	33
mhc alleles	33
proteasome system	33
cytokine secretion	33
cell culture	33
i restricted	33
inflammatory bowel	33
epitope mapping	33
adaptor protein	33
three different	33
virus particles	33
antigen receptor	33
ctl clones	33
associated protein	33
nile virus	33
type mice	33
pattern recognition	33
autoimmune encephalomyelitis	33
antigen specific	32
gene transfer	32
autophagy pathway	32
poorly understood	32
organ transplantation	32
inflammatory cells	32
phase i	32
bat species	32
limiting dilution	32
donor age	32
mrna levels	32
binding sites	32
infected astrocytes	32
immune complexes	32
two distinct	32
previously reported	31
progenitor cells	31
protein folding	31
negative selection	31
total rna	31
flow cytometric	31
i hla	31
hexavalent recombinant	31
aa insertion	31
room temperature	31
mg ml	31
human peripheral	31
peptide complex	31
sequence homology	31
nucleic acids	31
viral epitopes	31
ii major	31
tcr repertoire	31
bd biosciences	31
structural proteins	31
genes encoding	31
viral antigen	31
specific antibody	31
mice showed	31
animal model	30
signaling pathway	30
derived peptides	30
proteasomal degradation	30
results showed	30
analysis resource	30
derived dendritic	30
mammalian cells	30
first step	30
infected cell	30
mouse strains	30
one year	30
nkt cell	30
graft failure	30
shock protein	30
ctl activity	30
fc receptors	30
spinal cord	30
cd mab	30
human populations	29
recombinant proteins	29
western blotting	29
also found	29
serum levels	29
cells also	29
seminiferous epithelium	29
signal peptides	29
cells infected	29
major role	29
treg cells	29
protein structure	29
cells showed	29
cynomolgus macaques	29
heparan sulfate	29
specific ctls	29
proteasomal cleavage	29
ctl epitope	29
polymerase chain	29
binding affinities	29
hydrogen bonds	29
cell adhesion	29
systemic lupus	29
intracellular bacteria	29
ii epitopes	29
cell biology	28
foreign antigens	28
stimulatory molecules	28
different cell	28
papillomavirus type	28
cells via	28
vaccinated non	28
viral protein	28
human dendritic	28
statistically significant	28
renal allograft	28
antibody titers	28
negative control	28
autoimmune responses	28
fever virus	28
white matter	28
i major	28
chain reaction	28
type diabetes	28
many different	28
cervical cancer	28
fusion protein	28
cell tolerance	28
cell survival	28
antibody levels	28
growth factors	28
cd cell	27
determined using	27
inflammatory responses	27
linear epitopes	27
lymphoid organs	27
inflammatory diseases	27
pivotal role	27
male reproductive	27
inflammatory mediators	27
novel coronavirus	27
processing pathway	27
rna polymerase	27
term survival	27
survival rates	27
brain injury	27
transgenic mouse	27
immunogenic epitopes	27
epitopes using	27
reperfusion injury	27
gag processing	27
cell cultures	27
based peptide	27
clones specific	27
experimental autoimmune	27
islet allograft	27
single cell	27
memory cells	27
immune escape	27
months post	27
cells stimulated	27
renal transplantation	27
cells play	27
mechanisms involved	27
proliferative response	27
murine model	27
treated mice	27
choriomeningitis virus	27
analysis revealed	27
specific antigen	27
intercellular adhesion	27
total number	27
brain cells	27
bowel disease	27
genomic dna	27
reproductive tract	27
naturally occurring	27
tolerance induction	27
least two	27
molecular basis	27
high degree	27
effector functions	27
leydig cells	27
ischemia reperfusion	27
peptide sequence	27
survival rate	27
prediction tool	27
data demonstrate	27
molecular biology	26
adoptively transferred	26
gamma interferon	26
peptide peptidase	26
inflammatory cytokine	26
subcellular location	26
liver disease	26
antigenic determinants	26
listeria monocytogenes	26
er lumen	26
highest binding	26
lupus erythematosus	26
cells recognize	26
interferon gamma	26
apoptotic cell	26
potential role	26
wt mice	26
mhc peptide	26
signal sequences	26
cell infiltration	26
transfected cells	26
may represent	26
viral vectors	26
dimensional structure	26
ubiquitin ligases	26
gag retention	26
protein mixture	26
prediction method	26
mhc diversity	26
induced apoptosis	26
similar results	26
human blood	26
mice expressing	26
coronavirus infection	26
also used	26
exogenous antigens	26
binding predictions	26
viral gene	26
limited number	26
patients received	26
significantly decreased	26
stimulating factor	26
cytokine profile	25
reactive oxygen	25
marrow cells	25
positive control	25
produce il	25
inflammatory processes	25
th cytokines	25
nadph oxidase	25
several studies	25
viral load	25
blood lymphocytes	25
vaccinated dams	25
yellow fever	25
misfolded proteins	25
mhc products	25
persistent infection	25
mhc gene	25
years ago	25
statistical analysis	25
i ii	25
infected individuals	25
may result	25
united states	25
cmv infection	25
influenza viruses	25
chronic allograft	25
human monocytes	25
leukemia virus	25
wide variety	25
killer cell	25
proliferative responses	25
anchor residues	25
autophagosome formation	25
ii drb	25
surface antigens	25
derived cells	25
cytokines il	25
structural basis	25
surface receptors	25
analysis showed	25
leydig cell	25
transforming growth	25
inhibitory effect	25
clonal expansion	25
cell depletion	25
kidney recipients	25
histocompatibility antigens	25
proteins may	25
converting enzyme	25
lymphoid tissue	25
constitutively expressed	25
i gene	25
recombinant vaccinia	24
dc maturation	24
acute infection	24
cell transplantation	24
recombinant human	24
thymic epithelial	24
cells using	24
cholera toxin	24
immune genes	24
cell immune	24
signal sequence	24
lymphocyte activation	24
present antigen	24
helper cell	24
regulatory factor	24
lasv gp	24
escherichia coli	24
diabetes mellitus	24
oxide synthase	24
supplementary table	24
increased levels	24
antiviral activity	24
nucleic acid	24
conserved epitopes	24
i allele	24
dengue hemorrhagic	24
cell hybridomas	24
normal mice	24
different types	24
human population	24
tumor cell	24
human genome	24
human cells	24
blood pressure	24
living donor	24
i interferon	24
might also	24
studies using	24
cytotoxic activity	24
positive correlation	24
immune privilege	24
i pathway	24
nucleocapsid protein	24
hla dr	24
deceased donor	24
donor hd	24
binding peptide	24
following infection	24
cardiac allografts	24
newly synthesized	23
alloantibody binding	23
survival benefit	23
rna interference	23
infectious disease	23
mouse models	23
type iii	23
mer peptide	23
plasmacytoid dendritic	23
respiratory tract	23
transcriptional regulation	23
vaccine delivery	23
igg antibodies	23
epitopes derived	23
regulatory cells	23
avium subsp	23
express cd	23
cell help	23
mechanisms underlying	23
psychiatric disorders	23
surface accessibility	23
may occur	23
increased risk	23
surface markers	23
mm tris	23
healthy individuals	23
induction therapy	23
dna encoding	23
candidate epitopes	23
subcellular localization	23
sequence types	23
antibody mediated	23
autophagy machinery	23
dna delivery	23
surface proteins	23
poly i	23
peptides presented	23
body weight	23
immunoinformatics tools	23
peptides binding	23
programmed cell	23
pdb id	23
donor specific	23
oxidative stress	23
risk factor	23
core protein	23
restricted cytotoxic	23
mouse strain	23
artificial neural	23
neural network	23
high frequency	23
potential vaccine	23
pathogen diversity	23
effector function	23
humoral response	23
life cycle	22
subunit vaccine	22
binding domain	22
expression level	22
genetic variability	22
mycophenolate mofetil	22
predicted using	22
tumour antigens	22
mice lacking	22
mdbk cells	22
secretory pathway	22
virus strains	22
control mice	22
binding energy	22
immune regulation	22
ii peptide	22
silico analysis	22
auf die	22
peptide repertoire	22
i haplotypes	22
effi ciency	22
professional apcs	22
goat anti	22
ns protein	22
sars coronavirus	22
viral particles	22
significantly different	22
myeloid cells	22
oxygen species	22
binding epitopes	22
adaptor proteins	22
antigenic proteins	22
deficient cells	22
genome sequence	22
human brain	22
tyrosine kinase	22
ii gene	22
secondary structure	22
blood monocytes	22
tissue damage	22
blood donors	22
full length	22
surface antigen	22
authors declare	22
selected epitopes	22
testicular macrophages	22
producer cells	22
transfection effi	22
meld score	22
winged bat	22
peptides generated	21
binding region	21
autophagy may	21
three times	21
first line	21
two major	21
whole genome	21
spike protein	21
ms patients	21
indian rhesus	21
protective antigens	21
i surface	21
origin rhesus	21
immunogenic proteins	21
primary human	21
culture supernatants	21
united kingdom	21
cord blood	21
drb gene	21
autoimmune response	21
recent data	21
promiscuity level	21
gel electrophoresis	21
mice treated	21
murine coronavirus	21
nod mice	21
binding proteins	21
proteins involved	21
tumor antigens	21
immunological synapse	21
time point	21
peptides bound	21
cell lymphoma	21
prediction tools	21
epitope vaccine	21
findings suggest	21
conformational epitopes	21
like molecules	21
bipolar disorder	21
persistently infected	21
cell memory	21
allele frequency	21
within days	21
well known	21
salt bridges	21
humoral immunity	21
rna virus	21
using flow	21
neural networks	21
th th	21
widely used	21
related genes	21
like protein	21
viral diseases	21
inducing activity	21
cell activity	21
cd memory	21
mouse brain	21
bacterial infections	21
signalling pathways	21
logistic regression	21
th response	21
lower levels	21
marrow derived	21
negatively charged	21
may help	21
peptide fragments	21
experimental data	20
tap transport	20
hydrogen bond	20
investigated whether	20
pathological conditions	20
gamma delta	20
cell carcinoma	20
real time	20
acid substitutions	20
delivery system	20
glial cell	20
mouse mhc	20
cell level	20
spike glycoprotein	20
glucose tolerance	20
cancer immunotherapy	20
current study	20
cells derived	20
cytokine response	20
cellular rejection	20
infiltrating lymphocytes	20
intramembrane proteolysis	20
altered peptide	20
scientificreports www	20
molecule expression	20
cytokine expression	20
possible role	20
world health	20
restricted epitopes	20
kidney tx	20
blood vessels	20
macrophage activation	20
one month	20
mice deficient	20
demyelinating disease	20
elevated levels	20
better understanding	20
recent years	20
peptide tetramer	20
naturally processed	20
cerebrospinal fluid	20
cd antibodies	20
immunodominant epitope	20
presenting cell	20
highly polymorphic	20
cd rb	20
mhc drb	20
clinical trial	20
peptide vaccines	20
peptide epitopes	20
bioinformatics tools	20
multiple sequence	20
cd ro	20
recently shown	20
cell subset	20
heart transplantation	20
culture medium	20
day post	20
nuclear antigen	20
heart disease	20
different strains	20
freshly isolated	20
cell lysates	20
murine cytomegalovirus	20
predicted binding	20
evidence suggests	20
may act	20
antigenic protein	20
low dose	20
receptor expression	19
tlr ligand	19
shock proteins	19
cytokine signaling	19
emerging infectious	19
processing pathways	19
confocal microscopy	19
also called	19
commonly used	19
interstitial fibrosis	19
cell lysis	19
receptor complex	19
germ cell	19
er stress	19
bacterial infection	19
dr expression	19
mhv strains	19
northern blot	19
dna viruses	19
national institutes	19
significant reduction	19
ii expressing	19
cellular proteins	19
rejection episodes	19
avian influenza	19
acute phase	19
protective effect	19
threshold value	19
indirect pathway	19
vitro studies	19
cell apoptosis	19
patients receiving	19
transmembrane domain	19
binding assays	19
bovine serum	19
human immune	19
time course	19
transcriptional activation	19
promoter activity	19
highly specific	19
liver graft	19
highly expressed	19
overlapping peptides	19
spike peptide	19
cell compartment	19
melanoma cells	19
glycosylation sites	19
hcmv us	19
cells isolated	19
term graft	19
post transplant	19
hematopoietic stem	19
activated cd	19
epitope predictions	19
ii complexes	19
exogenous antigen	19
iedb server	19
iu ml	19
receptor binding	19
allele frequencies	19
conformational changes	19
disulfide bonds	19
intracellular cytokine	19
th responses	19
mean age	19
neural cells	19
epitope specificity	19
cell numbers	19
model system	19
essential role	19
cell stimulation	19
data bank	19
regulatory proteins	19
virulence factor	19
cytotoxic cd	19
donor kidney	19
rheumatoid arthritis	19
specific memory	19
bat transcriptome	19
intracellular pathogen	19
vaccinated mice	19
preliminary results	19
proteolytic cleavage	19
positively charged	19
chronic hepatitis	19
steady state	18
reactive cd	18
peptide antigens	18
protein antigen	18
normal conditions	18
healthy subjects	18
specific primers	18
i epitopes	18
cystic fibrosis	18
allelic diversity	18
ii molecule	18
pred balb	18
patients without	18
elispot assay	18
accessory cells	18
protein structures	18
studies suggest	18
virus clearance	18
multivariate analysis	18
renal allografts	18
studies showed	18
viral immune	18
cd cytotoxic	18
immunosuppressive regimen	18
blood group	18
immune systems	18
i proteins	18
smooth muscle	18
gene transcription	18
epitope sequences	18
nuclear factor	18
selected peptides	18
highly pathogenic	18
outer membrane	18
antibody binding	18
professional antigen	18
eukaryotic cells	18
vaccine constructs	18
er quality	18
persistent infections	18
host response	18
large amounts	18
epitopes identified	18
cysteine proteases	18
cell functions	18
protein data	18
preliminary data	18
cytomegalovirus us	18
cells produce	18
autophagy genes	18
tcr binding	18
renal failure	18
vesicular stomatitis	18
findings indicate	18
erad substrates	18
degradation pathway	18
activated macrophages	18
scid mice	18
cells transfected	18
cells following	18
complement activation	18
previous work	18
vascular endothelial	18
effector memory	18
envelope glycoprotein	18
different stages	18
two alleles	18
cd clones	18
cell growth	18
tap expression	18
low affinity	18
health organization	18
mhc polymorphism	18
restricted cd	18
macrophage colony	18
previous study	18
influenza vaccine	18
gene encoding	18
induced class	18
stomatitis virus	18
apm components	18
domestic cat	18
activated protein	18
immunological memory	18
low level	18
pulmonis infection	18
sle patients	18
may explain	18
transplant centers	18
surface mhc	18
epithelial cell	18
adherent cells	18
research center	18
showed significant	18
expression vector	18
mhc ligands	18
regulatory role	18
fusion proteins	18
axonal injury	18
membrane fusion	18
large numbers	18
node cells	18
lung cancer	18
self antigens	17
lymphoid cells	17
live attenuated	17
predicted epitope	17
unfolded protein	17
mhc mrna	17
transmembrane proteins	17
cultured human	17
factor receptor	17
specific igg	17
i ifns	17
fluorescent protein	17
mice vaccinated	17
graft dysfunction	17
viral titers	17
presented peptides	17
analysis using	17
dependent rna	17
acinonyx jubatus	17
breast cancer	17
calcineurin inhibitors	17
binding scores	17
different time	17
neural stem	17
unpublished data	17
cell migration	17
calculated using	17
light chain	17
signal peptidase	17
ec ii	17
analysis demonstrated	17
inducible nitric	17
cytokine il	17
jhmv infection	17
disease susceptibility	17
clinical studies	17
class iii	17
cd lymphocytes	17
virus strain	17
foxp expression	17
specific receptors	17
transduction pathways	17
microarray analysis	17
acid composition	17
creative commons	17
murine class	17
i epitope	17
waiting list	17
cd th	17
respiratory syncytial	17
host species	17
conservancy analysis	17
operational tolerance	17
molecules involved	17
support vector	17
foxp cells	17
vaccine construct	17
mouse igg	17
study demonstrates	17
middle east	17
inhibitory effects	17
tumor suppressor	17
cd antibody	17
cell killing	17
infection induces	17
may affect	17
stress response	17
secondary lymphoid	17
molecular patterns	17
currently available	17
several different	17
better understand	17
provide evidence	17
animal care	17
intestinal inflammation	17
specific cellular	17
dc activation	17
restricted antigen	17
accession numbers	17
bat influenza	17
tumor development	17
defense mechanisms	17
interferon regulatory	17
lt recipients	17
neurotropic coronavirus	17
specific hla	17
early stages	17
tlr tlr	17
restricted ctl	17
mst days	17
patienten mit	17
candidate genes	17
malignant cells	17
gene family	17
human melanoma	17
immune status	17
alpha beta	17
therapeutic potential	17
university school	17
predictive value	17
heterologous immunity	17
takes place	17
derived macrophages	17
may indicate	17
cell cross	17
charged residues	17
i complexes	17
tlr stimulation	17
bnp calves	17
cell maturation	17
see also	17
mediated cytotoxicity	17
presentation pathways	17
nucleotide sequence	17
remains unclear	17
may involve	17
associated molecular	17
delayed graft	17
cd ko	17
may influence	17
recent advances	17
tcr recognition	17
antibodies directed	16
total igg	16
take place	16
will also	16
biological activity	16
linear epitope	16
er dislocation	16
ligase activity	16
give rise	16
conserved regions	16
autodock vina	16
largely unknown	16
cutting edge	16
peptide ligand	16
results obtained	16
different species	16
long peptides	16
world population	16
protein level	16
renal cell	16
vast majority	16
studies show	16
mouth disease	16
effector cd	16
inbred strains	16
mhc restriction	16
final vaccine	16
vaccine antigens	16
epitopes within	16
immune activation	16
i protein	16
genes associated	16
situ hybridization	16
pei dna	16
specific mhc	16
specific responses	16
simian immunodeficiency	16
lymphocyte epitope	16
physicochemical properties	16
activation markers	16
ifn production	16
identified using	16
syncytial virus	16
autophagic machinery	16
hla supertypes	16
naive cd	16
type virus	16
cell contact	16
antiviral immune	16
east respiratory	16
cytokine receptors	16
recently described	16
severe disease	16
human class	16
extracellular domain	16
mhc region	16
dna sequence	16
peptides recognized	16
less likely	16
small number	16
hla allele	16
hidden markov	16
immune suppression	16
solid organ	16
genomic islands	16
public health	16
expression system	16
may function	16
mice compared	16
mononuclear cell	16
alleles hla	16
cellular responses	16
broad range	16
cns cells	16
allowed us	16
cardiac allograft	16
virus entry	16
rat brain	16
tlr signaling	16
maintenance immunosuppression	16
cell interactions	16
expressing cd	16
adverse effects	16
binding motif	16
relatively low	16
antigen binding	16
cd high	16
tubular atrophy	16
gene segment	16
also demonstrated	16
constitutive expression	16
viral nucleic	16
also play	16
much less	16
brain edema	16
large quantities	16
protein complexes	16
two independent	16
primary infection	16
genetic background	16
crystal structures	16
first year	16
allograft recipients	16
pfu ml	16
plant viruses	16
graft outcome	16
cells increased	16
vgamma vdelta	16
virus envelope	16
tumour necrosis	16
rat testis	16
clinical outcome	16
immune control	16
specific epitopes	15
neglected tropical	15
present data	15
drb locus	15
human coronavirus	15
inflammatory disease	15
igg levels	15
liquid chromatography	15
lysosomal degradation	15
peptide transporter	15
effective immune	15
receptor antagonist	15
epitopes recognized	15
whole blood	15
quantitative real	15
mediated lysis	15
receptor cd	15
direct interaction	15
sequence data	15
secreting cells	15
virus encephalitis	15
also identified	15
fluorescence intensity	15
side chain	15
two types	15
national institute	15
risk hpv	15
dna complexes	15
cell signaling	15
also analyzed	15
derived peptide	15
novel mechanism	15
danger signals	15
specific immunity	15
recipient age	15
peptide motifs	15
predicted mhc	15
dhf dss	15
endocytic pathway	15
inducible expression	15
tight junctions	15
immunoinformatics approach	15
vascular permeability	15
gene gun	15
located within	15
induced cell	15
silico approach	15
viral disease	15
will help	15
weight loss	15
clinical outcomes	15
different mechanisms	15
soluble antigen	15
also shown	15
serum samples	15
different peptides	15
induced colitis	15
common cause	15
functional analysis	15
first months	15
conformational change	15
hematopoietic cells	15
histocompatibility antigen	15
autophagy gene	15
fine specificity	15
derived epitopes	15
immune tolerance	15
kidney transplants	15
wide association	15
lipid rafts	15
cytokine profiles	15
infected animals	15
clinical signs	15
chemokine receptor	15
supplementary material	15
autophagy protein	15
thymic selection	15
protein levels	15
peptide prediction	15
epitopes may	15
cell expansion	15
plasma cell	15
recently reported	15
tlr ko	15
tcr activation	15
cell number	15
proposed epitope	15
following treatment	15
last decade	15
lymphoid tissues	15
dc function	15
chemokine receptors	15
candidate antigens	15
immunol doi	15
stimulated cells	15
clonal deletion	15
least three	15
allograft function	15
virus infected	15
cell cytotoxicity	15
brain tissue	15
clones isolated	15
response elicited	15
loading complex	15
kcal mol	15
ha peptides	15
may reflect	15
borne encephalitis	15
drb loci	15
specific tolerance	15
foxp treg	15
mixed lymphocyte	15
induced expression	15
negative bacteria	15
peptide docking	15
induced autophagy	15
cd ctl	15
candidate vaccine	15
cd molecules	15
cell specific	15
blood flow	15
classical mhc	15
analysed using	15
patients transplanted	15
predicted peptides	15
produce ifn	15
surface protein	15
gene segments	15
sclerosis lesions	15
ligand recognition	15
recent study	15
heart allografts	14
specific antigens	14
tlr activation	14
cell lung	14
cells without	14
mhc rtta	14
melanoma cell	14
ifng production	14
single nucleotide	14
lymphokine production	14
different viruses	14
receptor genes	14
airway inflammation	14
median follow	14
regulate autophagy	14
molecular mechanism	14
jurkat cells	14
signaling molecules	14
expression patterns	14
reverse transcriptase	14
early post	14
ic nm	14
cd effector	14
binding free	14
peptides corresponding	14
islet cell	14
viral entry	14
also examined	14
high binding	14
cd ra	14
location prediction	14
japanese encephalitis	14
ii hla	14
authorship attribution	14
cleavage site	14
kidney cells	14
chronic relapsing	14
cell pool	14
percentile rank	14
natural selection	14
negative regulator	14
dose dependent	14
hypothetical protein	14
cytokine staining	14
much higher	14
immune receptors	14
immunoinformatics approaches	14
ros production	14
expressed cd	14
dominant negative	14
well understood	14
chronic infections	14
cell homeostasis	14
protein database	14
transmembrane domains	14
monocytes macrophages	14
evolutionary history	14
cells bearing	14
peritoneal macrophages	14
single center	14
effective vaccine	14
nude mice	14
ulcerative colitis	14
also showed	14
protein response	14
cytometric analysis	14
two main	14
immune gene	14
foreign antigen	14
bei patienten	14
cytoplasmic domain	14
bound peptide	14
blood cell	14
epitope conservancy	14
head injury	14
well established	14
immune reactions	14
considered significant	14
alloantibody levels	14
leishmania major	14
previously identified	14
third party	14
cd molecule	14
conditioned media	14
strong binding	14
language models	14
acute cellular	14
tissue distribution	14
induced activation	14
conservation scores	14
polyubiquitin chains	14
lamina propria	14
transgenic animals	14
protein epitope	14
vivo gene	14
linked glycosylation	14
ii transactivator	14
clonal selection	14
cerebral blood	14
shock syndrome	14
transcriptional level	14
factor alpha	14
population structure	14
transformed cells	14
lymphocytes secreting	14
precursor protein	14
i interferons	14
immunoinformatic approach	14
generated using	14
chronic inflammation	14
likely due	14
post infection	14
candidate vaccines	14
complex antigen	14
studies indicate	14
double negative	14
antigen cross	14
effi cient	14
structure prediction	14
treated group	14
early stage	14
associated membrane	14
per se	14
cell priming	14
human primates	14
lymphocyte subsets	14
survival time	14
candidate subunit	14
vitro stimulation	14
ctl clone	14
associated antigen	14
neonatal pancytopenia	14
responses induced	14
neuronal cells	14
highly purified	14
foxp tregs	14
signalling pathway	14
supplementary information	14
transport efficiency	14
swine fever	14
tumor antigen	14
nuclear translocation	14
allow us	13
antigenic epitopes	13
virus persistence	13
susceptible mice	13
following transplantation	13
six months	13
recombinant virus	13
structural analysis	13
driven vaccines	13
surface class	13
two genes	13
increased cd	13
highly variable	13
brain parenchyma	13
virus proteins	13
specific cells	13
peptide mhc	13
experiments indicate	13
islet allografts	13
recent evidence	13
medical school	13
highly diverse	13
specific peptide	13
dependent diabetes	13
high concentrations	13
regulatory function	13
low density	13
randomly selected	13
future studies	13
different epitopes	13
cellular processes	13
emini surface	13
stress conditions	13
cpg dna	13
bovine neonatal	13
sensitized patients	13
therapeutic approaches	13
like virus	13
antiviral cd	13
also performed	13
positively selected	13
gene silencing	13
receptor recognition	13
acute encephalitis	13
mediated apoptosis	13
medical center	13
endogenous antigens	13
cancer patients	13
elevated icp	13
cellular location	13
viral dna	13
protein interactions	13
wide spectrum	13
lymphocytic infiltration	13
transduction pathway	13
comparative analysis	13
high risk	13
stable graft	13
htlv i	13
might play	13
extensively studied	13
adult human	13
histocompatibility class	13
cytokine levels	13
loading compartments	13
murine leukemia	13
cell levels	13
pcr products	13
may induce	13
cell infiltrates	13
iedb mhc	13
ii pathway	13
monoclonal anti	13
new vaccines	13
gives rise	13
cell dysfunction	13
ubiquitously expressed	13
well defined	13
cx cr	13
complex molecules	13
experimental evidence	13
alloimmune responses	13
lassa virus	13
limb paralysis	13
ii proteins	13
cytokine responses	13
gtko mcp	13
significant role	13
acid change	13
cell proliferative	13
disease pathogenesis	13
alloreactive cd	13
hace expression	13
prediction using	13
selective pressure	13
candidate proteins	13
adult mice	13
university hospital	13
i ligands	13
clinical symptoms	13
different hla	13
drb sequences	13
specific cell	13
immunodominant peptides	13
signalling molecules	13
geometric mean	13
flavivirus infection	13
tumour cells	13
tcr transgenic	13
current knowledge	13
inhibitory receptors	13
cell lysate	13
nucleotide substitutions	13
cells expressed	13
relatively high	13
spinal cords	13
effector mechanisms	13
allogeneic mhc	13
publicly available	13
first evidence	13
proteolytic activity	13
antigen specificity	13
stabilized matrix	13
expression profile	13
described previously	13
rabbit anti	13
protein peptide	13
cytokine release	13
many viruses	13
murine models	13
map kinase	13
blood cells	13
recently identified	13
results indicated	13
jak stat	13
previously demonstrated	13
transplant model	13
cell suspensions	13
purified cd	13
protective role	13
protein docking	13
i region	13
jhmv replication	13
cytotoxicity assay	13
well characterized	13
response induced	13
tightly regulated	13
allograft nephropathy	13
new insights	13
linked immunosorbent	13
coronavirus nucleocapsid	13
dengue disease	13
effector cell	13
serum antibody	13
transplant center	13
also important	13
marrow transplantation	13
secreting ifn	13
cd nkg	13
specific anti	13
two peptides	13
chronic infection	13
retinoic acid	13
transplantation tolerance	13
genetic studies	13
anchor residue	13
mutant mice	13
beta i	13
dk services	13
mhc interactions	13
autism spectrum	13
four different	13
tcr ligands	13
onto mhc	13
self peptides	13
multiple comparisons	13
murine hepatitis	13
lps stimulation	13
first days	13
cfse lo	13
like proteins	13
expression profiles	13
significantly less	13
cells might	13
conserved region	13
based prediction	13
skin grafts	13
coronary heart	13
pcr amplification	13
also significantly	13
machine learning	13
interstitial tissue	13
free radicals	13
evaluated using	13
cd complex	13
virus may	13
induce class	13
medium containing	12
results provide	12
persistent viral	12
single dose	12
large set	12
viral peptide	12
based approaches	12
producing ifn	12
marker cd	12
transendothelial migration	12
salivary glands	12
data analysis	12
primary response	12
derived dc	12
prediction server	12
antiviral responses	12
infected npcs	12
cells respond	12
bacterial pathogens	12
local immune	12
autoimmune disorders	12
red blood	12
dna binding	12
self mhc	12
testicular function	12
vaccine discovery	12
brain swelling	12
independent manner	12
ctl lines	12
th clones	12
genbank accession	12
vaccines based	12
tcr signaling	12
control cells	12
significantly enhanced	12
host factors	12
donor liver	12
inclusion bodies	12
ii compartment	12
cytoplasmic tail	12
important implications	12
small intestine	12
murine encephalomyelitis	12
first week	12
disease severity	12
ox immunoreactivity	12
conjugated anti	12
fas ligand	12
helper epitopes	12
ge healthcare	12
i supertypes	12
free energy	12
without prior	12
tropical diseases	12
induced demyelination	12
disease activity	12
human igg	12
virus core	12
human fetal	12
brazilian population	12
previously showed	12
costimulatory signals	12
major source	12
iii pi	12
two weeks	12
hla genes	12
term outcome	12
lesser extent	12
kidney graft	12
false discovery	12
causative agent	12
data obtained	12
fluorescence microscopy	12
based mhc	12
humoral rejection	12
may serve	12
low expression	12
immunological tolerance	12
inflammatory protein	12
viral protease	12
effective vaccines	12
electron microscopy	12
relapsing experimental	12
rational design	12
mhc variability	12
regulatory elements	12
significantly associated	12
actin cytoskeleton	12
recently developed	12
may become	12
target gene	12
also able	12
lung transplant	12
point mutations	12
chronic demyelination	12
receptor signaling	12
substrate selection	12
antigen discovery	12
western blots	12
breast milk	12
inflammatory stimuli	12
binding domains	12
year post	12
restricted epitope	12
response may	12
marginal zone	12
future research	12
protease inhibitor	12
mediated autophagy	12
therapeutic interventions	12
cell mhc	12
cell deficient	12
phage display	12
less efficient	12
nucleotide sequences	12
tap transporter	12
adverse events	12
assessed using	12
hla allotypes	12
leukocyte receptor	12
organ transplant	12
immune interferon	12
signal transducer	12
inducible gene	12
processing machinery	12
protective efficacy	12
immunogenic peptides	12
terminal end	12
dengue patients	12
cultured astrocytes	12
selection pressure	12
genetic distance	12
ia antigens	12
antibody formation	12
splenic lymphocytes	12
using elisa	12
cns disease	12
commons license	12
signaling cascades	12
associated proteins	12
novel approach	12
cell dependent	12
dr binding	12
mhc haplotypes	12
strong immune	12
patients compared	12
infection may	12
flow cytometer	12
acidic protein	12
virion infectivity	12
cleavage sites	12
suppressive function	12
hendra virus	12
dna plasmid	12
study provides	12
hla haplotype	12
almost exclusively	12
tongaonkar antigenicity	12
based approach	12
dc subsets	12
vitro culture	12
immature dc	12
cd positive	12
normal human	12
applied biosystems	12
may depend	12
vaccine encoding	12
high throughput	12
classical swine	12
signaling cascade	12
myelin antigens	12
protein vaccine	12
cd deficient	12
quantitative analysis	12
box protein	12
gene conversion	12
immunoglobulin heavy	12
epitope complexes	12
specific inhibition	12
direct effect	12
allogeneic transplantation	12
matrix method	12
viruses may	12
swedish moose	12
different levels	12
treated patients	12
ctl specific	12
also induce	12
vivo studies	12
effector molecules	12
drug discovery	12
peptides spanning	12
fibrillary acidic	12
functional avidity	12
serum albumin	12
tissue destruction	12
statistical significance	12
consensus sequence	12
vitro experiments	12
latent infection	12
increased number	12
productive infection	12
factors involved	12
healthy volunteers	12
membrane glycoprotein	12
tyrosine phosphorylation	12
avium subspecies	12
processing components	12
antigenic sites	12
cytolytic activity	12
newborn mice	12
genome sequences	12
glial fibrillary	12
binding specificity	12
pigeon cytochrome	12
macaque mhc	12
neurological disease	12
map infection	12
tyrosine kinases	12
many studies	12
vasogenic edema	12
monocytic cells	12
clinical data	12
cells present	12
human renal	12
specific binding	12
peptide epitope	12
regulatory protein	12
isolation membrane	12
antigens presented	12
cell entry	12
well tolerated	12
th cell	12
imgt hla	12
foxp mrna	12
protocol biopsies	12
chain gene	12
significantly elevated	12
peptide libraries	12
cells activated	12
inhibitory concentration	12
calcineurin inhibitor	12
blood cd	12
peripheral tolerance	12
porcine dc	12
findings demonstrate	12
cd tc	12
hla molecule	12
skin allograft	12
five different	12
tcr repertoires	12
vascular endothelium	12
kidney donors	12
mice administered	12
hla abs	12
homology modelling	12
ic value	11
transgene expression	11
recipient mice	11
cpg motifs	11
human tumor	11
become activated	11
cerebellar degeneration	11
guinea pigs	11
also possible	11
cells cultured	11
mhc haplotype	11
drinking water	11
nuclear localization	11
transplant tolerance	11
mycoplasma pulmonis	11
putative epitopes	11
htl epitopes	11
stimulate class	11
studies demonstrated	11
rat model	11
proinflammatory cytokine	11
i histocompatibility	11
activated microglia	11
cns inflammation	11
hla antibodies	11
control animals	11
flying fox	11
evidence indicates	11
years post	11
somatic cells	11
seminal plasma	11
colitis model	11
substrate specificity	11
higher binding	11
acid substitution	11
francisella tularensis	11
research institute	11
patients suffering	11
binding data	11
provide new	11
culture conditions	11
vaccine targets	11
human mast	11
peptide antigen	11
protein aggregates	11
highly sensitive	11
driven selection	11
highest number	11
mhc hc	11
developing countries	11
costimulatory molecule	11
also increased	11
matrix protein	11
negative feedback	11
structural features	11
open reading	11
neurodegenerative diseases	11
immune memory	11
mauritian cynomolgus	11
increased production	11
malignant transformation	11
murine macrophages	11
also evaluated	11
default parameters	11
clones derived	11
heart failure	11
species polymorphism	11
lymphocyte reaction	11
available data	11
previously published	11
cellular stress	11
expert system	11
staphylococcus aureus	11
high titers	11
porcine pdc	11
general population	11
surface cd	11
see table	11
strongly suggest	11
epitopes prediction	11
human disease	11
immune mechanisms	11
mice results	11
cell recruitment	11
whole mounts	11
er degradation	11
major cause	11
apoptosis induced	11
cells induced	11
study shows	11
ramachandran plot	11
rejection rate	11
mutation rate	11
renal insufficiency	11
large scale	11
receptor repertoire	11
hiv vaccine	11
population dynamics	11
suppressor cells	11
peptide presented	11
also associated	11
single epitope	11
lysine residues	11
also determined	11
virus nucleoprotein	11
cdr length	11
haemorrhagic fever	11
results may	11
deubiquitinating enzymes	11
stable patients	11
immunoreactive proteins	11
nonhuman primates	11
airway epithelium	11
van der	11
time period	11
infected host	11
significant decrease	11
san diego	11
normal cns	11
reverse transcription	11
years old	11
generation sequencing	11
individual peptides	11
aiv np	11
hpv types	11
uninfected cells	11
cysteine protease	11
fatty acids	11
vice versa	11
ha mer	11
cell sorting	11
mhc epitopes	11
peptide pool	11
binding capacity	11
induced tumors	11
year follow	11
primary astrocytes	11
viral pathogens	11
binding cleft	11
myocardial infarction	11
force field	11
secreted proteins	11
tubular epithelial	11
selected region	11
specific expression	11
enhanced immune	11
southeast asia	11
i mrna	11
west africa	11
mediated induction	11
ligand binding	11
chimeric mhc	11
expression profiling	11
reduced capacity	11
following exposure	11
major psychiatric	11
high number	11
specific tcr	11
tcr contact	11
binding activity	11
days later	11
mouse macrophages	11
tlr expression	11
hla system	11
study group	11
developed countries	11
ii epitope	11
free rats	11
allograft tolerance	11
mouse ifn	11
foxp regulatory	11
derived mhc	11
express high	11
progressive multifocal	11
molecules using	11
immune regulatory	11
normal cellular	11
kidney disease	11
antiviral therapy	11
using two	11
capsid protein	11
green fluorescent	11
classical hla	11
pathogen recognition	11
alloimmune response	11
first two	11
induce apoptosis	11
trained language	11
hla binding	11
selected based	11
peritubular cells	11
immune functions	11
cross presentation	11
solution containing	11
highly effective	11
multifocal leukoencephalopathy	11
cells producing	11
tlr agonists	11
state levels	11
two cell	11
also present	11
fruit bats	11
protein peptides	11
three species	11
high cd	11
docking analysis	11
cells generated	11
ischemia time	11
higher rate	11
high resolution	11
proliferation assays	11
donor cells	11
relatively small	11
one mechanism	11
increased frequency	11
often used	11
response towards	11
cells resulted	11
genetic differences	11
within hours	11
completely inhibited	11
higher risk	11
tracheal mucosa	11
physiological relevance	11
kidney donation	11
may include	11
may cause	11
meld scores	11
large extent	11
heart grafts	11
viral clearance	11
cancer vaccines	11
airway epithelial	11
high incidence	11
severe dengue	11
leader proteins	11
epitope identification	11
protein interaction	11
anchor positions	11
tetanus toxoid	11
immunodominant epitopes	11
calcium influx	11
way anova	11
ifn signal	11
maximal inhibitory	11
precursor frequency	11
soluble factors	11
assay using	11
side properties	11
tcr genes	11
retinal pigment	11
serum antibodies	11
surface glycoprotein	11
type hypersensitivity	11
ibd patients	11
mediated responses	11
dynamics simulation	11
carcinoma cell	11
death receptor	11
two mhc	11
single antigen	11
immune reaction	11
rat astrocytes	11
cellular protein	11
human astrocytes	11
completely understood	11
discovery rate	11
thank dr	11
like viruses	11
sequence variation	11
using anti	11
proteolytic processing	11
infiltrating cd	11
enveloped viruses	11
transmembrane protein	11
patients treated	11
epitope content	11
functional properties	11
blood glucose	11
cold ischemia	11
associated antigens	11
parasite species	11
strong association	11
ii restricted	11
mannose receptor	11
mediated activation	11
inclusion criteria	11
weeks post	11
kidney allografts	11
independent pathway	11
patient tnbc	11
influenza hemagglutinin	11