trigram

This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

trigram	frequency
mhc class i	1116
cd t cells	691
as well as	585
mhc class ii	566
the presence of	509
major histocompatibility complex	405
the expression of	334
the development of	330
of mhc class	320
the role of	318
cd t cell	292
the immune system	280
class i molecules	268
the number of	251
cd and cd	240
the absence of	238
in the presence	238
of the immune	237
in response to	229
in this study	222
cells in the	220
the mhc class	212
class i and	210
class i mhc	209
one of the	206
t cell receptor	206
been shown to	205
in order to	205
class ii mhc	199
the use of	193
role in the	193
the induction of	189
t cells in	188
the immune response	183
of t cell	181
a number of	177
the t cell	174
based on the	170
in the absence	169
is associated with	165
expression of the	162
t cell responses	162
of cd t	160
involved in the	157
central nervous system	156
histocompatibility complex class	156
the cell surface	154
of class i	154
analysis of the	150
in patients with	150
of the mhc	149
the production of	148
the effect of	147
a variety of	147
t cells and	143
of t cells	143
the context of	143
t cell clones	139
a role in	136
has been shown	134
and cd t	133
we found that	132
it has been	131
t cell epitopes	131
in the context	131
the ability of	128
the generation of	128
the activation of	127
specific cd t	124
t cells were	123
class ii molecules	123
the pathogenesis of	123
in addition to	123
hla class i	123
the endoplasmic reticulum	120
class i expression	120
t cell activation	119
immune response to	116
the identification of	114
the majority of	114
was used to	113
as compared to	112
due to the	111
the central nervous	110
to determine the	109
shown to be	109
complex class i	108
human immunodeficiency virus	106
in contrast to	106
the regulation of	106
and class ii	105
the effects of	104
the present study	103
according to the	102
tumor necrosis factor	102
data suggest that	102
in terms of	101
t cell response	101
in the cns	101
found to be	101
high levels of	101
class i antigen	98
in vitro and	98
the surface of	98
of class ii	97
play a role	97
balb c mice	97
i and class	96
an important role	96
of the t	96
of this study	95
are involved in	95
have shown that	95
such as the	94
an increase in	93
their ability to	92
cytotoxic t lymphocytes	92
associated with the	92
is required for	91
by flow cytometry	91
the level of	89
t cells are	88
have been shown	88
activation of the	88
well as the	88
structure of the	88
t cells from	87
gd t cells	87
to be a	86
the major histocompatibility	86
are able to	86
the importance of	86
suggest that the	85
was associated with	85
on the other	85
the case of	85
i and ii	83
the ability to	82
of patients with	82
expression of mhc	82
this study was	82
compared to the	82
specific t cells	81
the class i	81
specific t cell	81
important role in	81
in the present	80
study was to	80
part of the	80
a total of	80
to investigate the	79
of the peptide	79
memory t cells	79
in the er	79
on the surface	79
and in vivo	78
was found to	78
be involved in	78
we show that	78
innate and adaptive	77
the lack of	77
the control of	76
contribute to the	76
cytotoxic t cells	76
the other hand	76
in the case	76
of the human	75
results suggest that	75
the er membrane	74
some of the	74
there is a	73
cells of the	73
a role for	73
as a result	72
of the cd	72
appears to be	72
vitro and in	72
the function of	72
and mhc class	72
t cell proliferation	72
the aim of	71
antigen presenting cells	71
can be used	71
myelin basic protein	71
be used to	71
in the pathogenesis	71
the treatment of	71
in t cell	70
there was no	69
the frequency of	69
for the development	68
t cell epitope	68
were able to	68
in the development	68
to mhc class	68
for mhc class	68
and t cell	67
it is not	67
were used to	67
appear to be	67
components of the	67
is involved in	67
of major histocompatibility	67
of the virus	66
associated with a	66
has also been	66
regulatory t cells	66
hepatitis c virus	66
the time of	66
expression of class	66
t h e	66
of the tcr	65
role of the	65
herpes simplex virus	65
is mediated by	65
has not been	64
increase in the	64
class i alleles	64
in the first	63
the formation of	63
processing and presentation	63
of the protein	63
most of the	63
was determined by	63
of the hla	63
severe acute respiratory	63
a series of	63
c bl mice	63
acute respiratory syndrome	62
in the thymus	62
a panel of	62
derived from the	62
the binding of	62
differences in the	62
and in the	62
it is possible	61
at the time	61
cd t lymphocytes	61
understanding of the	60
the prediction of	60
members of the	60
of hla class	59
of cd and	59
but not in	59
class i molecule	59
in the regulation	59
cytotoxic t lymphocyte	59
binding to the	59
of the antigen	59
and function of	59
the course of	59
of the disease	59
changes in the	58
of the major	58
of the most	58
used for the	58
present in the	58
expression of cd	58
the mhc i	58
specific for the	57
of the host	57
region of the	57
the activity of	57
surface expression of	56
with respect to	56
was observed in	56
cell epitope prediction	56
a result of	56
of these cells	56
are associated with	56
showed that the	56
the recognition of	56
mouse hepatitis virus	56
were found to	56
to the mhc	56
we have previously	56
these data suggest	56
the percentage of	55
responsible for the	55
aim of this	55
from the er	55
on the cell	55
is thought to	55
in which the	55
may contribute to	55
in the immune	55
gene expression in	55
found in the	54
we investigated the	54
the fact that	54
play an important	54
response to the	54
at the cell	54
antigen processing and	54
influenza a virus	54
the release of	54
of dendritic cells	54
in combination with	53
an immune response	53
in comparison to	53
observed in the	53
hla class ii	53
there was a	53
have been identified	53
expression in the	53
in the central	53
t cell repertoire	53
class i genes	52
is essential for	52
for the first	52
is the most	52
the presentation of	52
immune responses to	52
the addition of	52
class ii antigen	52
in the human	52
regulation of the	52
seems to be	52
that can be	51
mhc antigen expression	51
t cell recognition	51
between the two	51
has been reported	51
required for the	51
the incidence of	51
to the cell	51
b cells and	51
these results suggest	51
immune response in	51
to determine whether	51
immunodeficiency virus type	51
t cells with	50
known to be	50
the interaction of	50
the impact of	50
t cells by	50
to study the	50
used as a	50
is one of	50
to evaluate the	50
in multiple sclerosis	50
the results of	50
at least one	49
is based on	49
data indicate that	49
the specificity of	49
the levels of	49
the basis of	49
a and b	49
likely to be	49
of the class	48
depending on the	48
we conclude that	48
the adaptive immune	48
each of the	48
detected in the	48
the mechanism of	48
to assess the	48
the amount of	48
cell responses to	47
the amino acid	47
ctl escape mutants	47
in the same	47
the possibility that	47
the innate immune	47
of antigen presentation	47
reactive t cells	47
be able to	47
to that of	47
by mhc class	47
when compared to	47
member of the	47
to predict the	47
by t cells	47
have been described	46
a combination of	46
to be the	46
was used for	46
associated with antigen	46
the analysis of	46
the design of	46
and activation of	46
levels of il	46
class i antigens	46
as previously described	46
results indicate that	45
obtained from the	45
were treated with	45
class i binding	45
i mhc molecules	45
is an important	45
dendritic cells and	45
large number of	45
wang et al	45
all of the	45
a subset of	45
antigen expression on	45
is able to	45
the loss of	45
class ii expression	45
related to the	45
t and b	45
binding to mhc	45
t cell lines	45
of the peptides	44
to cd t	44
may be a	44
of the patients	44
complex class ii	44
be due to	44
have been reported	44
data not shown	44
is known to	44
i and mhc	44
suggests that the	44
amino acid sequence	44
and b cells	44
was carried out	44
of the innate	44
the selection of	44
mice immunized with	43
l and l	43
we demonstrate that	43
dependent on the	43
characterization of the	43
are required for	43
wide range of	43
and dendritic cells	43
a set of	43
is characterized by	43
of mhc i	43
was assessed by	43
mhc i molecules	43
t cells that	43
e l l	43
in t cells	43
thought to be	43
class ii mrna	42
t cells was	42
due to a	42
cells specific for	42
antigen presentation by	42
in the early	42
vg vd t	42
immune epitope database	42
the cd t	42
experimental allergic encephalomyelitis	42
production of il	42
have been used	42
of the cells	42
to bind to	42
the most common	42
the class ii	42
hepatitis b virus	42
we have shown	42
be associated with	42
the first time	42
also known as	42
the process of	42
led to the	41
low levels of	41
our understanding of	41
montanide isa v	41
by cd t	41
antigen presentation pathway	41
a t cell	41
of b cell	41
can be induced	41
suggesting that the	41
end of the	41
in some cases	41
there is no	41
presence of a	41
with mhc class	41
to the development	41
the host immune	41
of the two	41
t cells to	41
dendritic cells in	41
cells can be	41
on the basis	41
are known to	41
and can be	40
respiratory syndrome coronavirus	40
cells from the	40
on mhc class	40
the degree of	40
the end of	40
mediated by the	40
of the cns	40
blood mononuclear cells	40
and b cell	40
the nature of	40
were detected in	40
to identify the	40
been shown that	40
human leukocyte antigen	40
included in the	40
were used as	40
as shown in	40
specificity of the	40
indicate that the	40
in the control	40
show that the	40
remains to be	40
c e l	40
immune response against	39
from patients with	39
of mice with	39
this study we	39
is dependent on	39
proteins in the	39
in the induction	39
with antigen processing	39
surface of the	39
interaction with the	39
resulted in a	39
and characterization of	39
in the brain	39
demonstrated that the	39
bind to the	39
bat mhc i	39
supported by the	39
development of a	39
a wide range	39
been used to	39
control of the	38
to be involved	38
the b m	38
the onset of	38
this is the	38
sequence of the	38
well as in	38
for prediction of	38
was significantly higher	38
results in the	38
in peripheral blood	38
adaptive immune responses	38
peripheral blood mononuclear	38
e and e	38
the immunogenicity of	38
the rate of	38
the interaction between	38
activated t cells	38
the risk of	38
peptide binding to	38
in the rat	38
leading to the	38
in mhc class	38
results in a	38
of the epitope	38
cells and the	38
a consequence of	37
cells in a	37
human and mouse	37
to play a	37
may lead to	37
compared with the	37
cell responses in	37
the hypothesis that	37
in the number	37
t cell receptors	37
the site of	37
central role in	37
is due to	37
high level of	37
memory cd t	37
for t cell	37
in the spleen	37
was able to	37
nature of the	37
t cells specific	37
found that the	37
function of the	37
specific cytotoxic t	37
one or more	37
as a consequence	37
immune responses in	37
activity of the	37
little is known	37
mice infected with	37
increased expression of	36
for the treatment	36
shown that the	36
the capacity to	36
transporter associated with	36
studies have shown	36
in association with	36
we hypothesized that	36
the study of	36
we observed that	36
was shown to	36
of b cells	36
peptides derived from	36
presence of the	36
crystal structure of	36
binding of the	36
type i ifn	36
we showed that	36
may not be	36
and adaptive immunity	36
implicated in the	36
the contribution of	36
the cells were	36
consistent with the	36
that have been	36
in the cytosol	36
identified in the	36
based on a	35
lead to the	35
may also be	35
essential for the	35
can also be	35
t cells can	35
was supported by	35
been associated with	35
a large number	35
a central role	35
delta t cells	35
the plasma membrane	35
in the mouse	35
i antigen presentation	35
of the b	35
that there is	35
a n t	35
amino acid residues	35
adaptive immune response	35
revealed that the	35
in vivo and	35
cell response to	35
in the mhc	35
innate immune response	35
renal transplant recipients	35
been reported to	35
with the mhc	34
cell epitopes of	34
was detected in	34
b cell epitopes	34
isolated from the	34
cell epitopes in	34
shown in fig	34
a critical role	34
class ii binding	34
which can be	34
and adaptive immune	34
protein disulfide isomerase	34
the bone marrow	34
our data suggest	34
contrast to the	34
more than one	34
the influence of	34
is known about	34
by means of	34
genes involved in	34
cytokines such as	34
have also been	34
the discovery of	34
to the er	34
some of these	34
the outcome of	34
single amino acid	34
many of the	34
response in the	34
antigen presentation and	34
the b cell	34
of the same	34
its role in	34
been implicated in	34
of amino acids	34
a crucial role	33
of the vaccine	33
have been developed	33
with or without	33
the amino acids	33
may play a	33
leads to the	33
recognized by the	33
ii antigen presentation	33
used in the	33
the immune epitope	33
was confirmed by	33
west nile virus	33
in the endoplasmic	33
residues in the	33
to analyze the	33
cells in vitro	33
class ii alleles	33
cytotoxic t cell	33
regions of the	33
li et al	33
b and t	33
the response to	33
was performed using	33
the structure of	33
cell activation and	33
dengue virus infection	33
by dendritic cells	33
before and after	33
the detection of	33
similar to the	33
human t cell	33
able to induce	33
at the same	33
is possible that	33
are present in	32
the efficacy of	32
and that the	32
at least in	32
is the first	32
were shown to	32
the maintenance of	32
effector t cells	32
in the treatment	32
the mechanisms of	32
innate immune system	32
the peripheral blood	32
the relationship between	32
are capable of	32
were determined by	32
or absence of	32
response to a	32
host immune response	32
in both groups	32
and graft survival	32
because of the	32
i expression in	32
the severity of	32
virus infection of	32
and regulation of	32
ii mhc antigen	32
for the induction	32
of immune responses	32
of expression of	32
the host cell	32
are shown in	32
insights into the	32
class ii presentation	32
amino acid sequences	32
and in vitro	32
the sequence of	32
the recruitment of	32
within the cns	32
cell surface expression	31
to respond to	31
binding affinity to	31
is responsible for	31
class i heavy	31
can lead to	31
results show that	31
was used as	31
in the liver	31
have demonstrated that	31
the occurrence of	31
no effect on	31
to test the	31
that of the	31
both cd and	31
sequences of the	31
of the proteasome	31
the proliferation of	31
of cytotoxic t	31
by the immune	31
and presentation of	31
the existence of	31
in this context	31
to t cells	31
has been described	31
of type i	31
of the p	31
of the brain	31
of the ifn	31
act as a	31
such as il	31
was measured by	31
of multiple sclerosis	31
is supported by	31
the potential to	31
t cell clone	31
amino acids in	31
t h a	30
flow cytometry and	30
we examined the	30
are essential for	30
a group of	30
component of the	30
with the same	30
at room temperature	30
in these cells	30
data show that	30
inhibition of the	30
of the first	30
recognition by the	30
the possibility of	30
a lack of	30
hexavalent recombinant protein	30
a member of	30
to understand the	30
i o n	30
were isolated from	30
of the h	30
to the immune	30
this work was	30
similar to that	30
natural killer cells	30
effect on the	30
in this process	30
adaptive immune system	30
demonstrate that the	30
of mhc molecules	30
the secretion of	30
is consistent with	30
significantly higher in	30
results demonstrate that	30
the combination of	30
of peptide binding	30
t i o	30
a mouse model	30
the purpose of	30
h a t	30
to determine if	30
depends on the	30
memory b cells	29
cell recognition of	29
were performed using	29
were obtained from	29
in a variety	29
a key role	29
molecules in the	29
as measured by	29
b f cells	29
in the host	29
class i presentation	29
for the generation	29
of the a	29
and expression of	29
of the anti	29
of cd cd	29
immune system and	29
we analyzed the	29
of the adaptive	29
the observation that	29
by the proteasome	29
has been used	29
kidney transplant recipients	29
class i peptide	29
induction of class	29
the kinetics of	29
of the sars	29
of the cell	29
for the prediction	29
to characterize the	29
in antigen presentation	29
the result of	29
cd or cd	29
naive t cells	29
ii major histocompatibility	29
these results demonstrate	28
mechanism by which	28
at the level	28
to the cytosol	28
use of the	28
of cell surface	28
vd t cells	28
was analyzed by	28
class ii antigens	28
higher levels of	28
the molecular mechanisms	28
this is a	28
during the first	28
the type of	28
were stimulated with	28
derived dendritic cells	28
interacts with the	28
t cell subsets	28
the capacity of	28
presentation of the	28
expressed in the	28
were identified in	28
the action of	28
memory t cell	28
of autophagy in	28
has been demonstrated	28
cells within the	28
were associated with	28
cell proliferation and	28
ii mhc antigens	28
shown in table	28
had no effect	28
years of age	28
be used for	28
it is also	28
were selected for	28
of the viral	28
levels of mhc	28
were analyzed by	28
we have used	28
in the normal	28
we have recently	28
human papillomavirus type	28
the autophagy pathway	28
associated with an	28
have not been	28
t lymphocyte responses	28
class i major	28
presented by mhc	28
there is an	28
considered to be	28
the target cell	28
have previously shown	28
humoral immune response	28
to mhc molecules	28
in the testis	27
class ii genes	27
cells as well	27
is possible to	27
for cd t	27
fold increase in	27
determined by the	27
i t h	27
the in vivo	27
resulted in the	27
in conjunction with	27
identification of a	27
be used as	27
this suggests that	27
been described in	27
study of the	27
characterized by a	27
also been shown	27
in both the	27
school of medicine	27
none of the	27
into the cytosol	27
for class i	27
by binding to	27
of immune response	27
class ii major	27
activation of t	27
the binding affinity	27
the phenotype of	27
in mice and	27
size of the	27
of mouse hepatitis	27
were carried out	27
us and us	27
cells have been	27
inflammatory bowel disease	27
significantly higher than	27
mhc molecules and	27
that may be	27
the functions of	27
in the blood	27
presence or absence	27
of ctl escape	27
one of these	26
there are two	26
t cells is	26
the need for	26
the initiation of	26
than that of	26
which is a	26
infection in the	26
heat shock protein	26
are likely to	26
systemic lupus erythematosus	26
recombinant protein mixture	26
i major histocompatibility	26
polymerase chain reaction	26
the repertoire of	26
at the end	26
in the generation	26
could be used	26
bonds with the	26
acts as a	26
of the infection	26
express mhc class	26
total number of	26
in b cells	26
diseases such as	26
the diversity of	26
was performed by	26
ability of the	26
be explained by	26
of gene expression	26
lymphocytic choriomeningitis virus	26
of the central	26
the distribution of	26
it is likely	26
contributes to the	26
a family of	26
previously shown that	26
stability of the	26
is regulated by	26
the salt bridge	26
t helper cells	26
to interact with	26
is not yet	26
the er lumen	26
the ctl response	26
as a model	26
after stimulation with	26
n t i	26
of human immunodeficiency	26
of viral proteins	26
to the same	26
the differentiation of	26
limited number of	26
need to be	26
at least two	26
signal peptide peptidase	26
was found in	26
chinese rhesus macaques	26
in balb c	26
is important to	26
the accumulation of	26
plays an important	26
expression of a	26
the degradation of	25
could not be	25
in transgenic mice	25
is not known	25
not associated with	25
in the periphery	25
we hypothesize that	25
was seen in	25
protective immune response	25
properties of the	25
of the cellular	25
the brains of	25
innate immune responses	25
t r a	25
draining lymph nodes	25
terminus of the	25
reported to be	25
used in this	25
adoptive transfer of	25
role for the	25
the potential for	25
even in the	25
levels of cd	25
in a dose	25
critical role in	25
cell lines and	25
human dendritic cells	25
identification of the	25
to be more	25
is shown in	25
were found in	25
immune responses and	25
of the er	25
high degree of	25
with regard to	25
has been suggested	25
difference between the	25
the inhibition of	25
has been proposed	25
it was found	25
is a key	25
tlr and tlr	25
we used the	25
cells in vivo	25
the same time	25
patient and graft	25
autoreactive t cells	25
the response of	25
differential expression of	25
that bind to	25
simplex virus type	25
and class i	25
t cell and	25
of antigen processing	25
mhc i hla	25
in the production	25
compared to control	25
i n g	25
is crucial for	25
functions of the	25
the highest binding	25
of the il	25
in the adult	25
in humans and	25
the cd cd	25
we have identified	25
in line with	25
reactive t cell	25
out of the	24
t cell development	24
as a potential	24
wide variety of	24
results showed that	24
the proportion of	24
in the cytoplasm	24
in the activation	24
we have developed	24
i heavy chains	24
is a major	24
as compared with	24
in the expression	24
expression of hla	24
the length of	24
to be associated	24
the inflammatory response	24
the involvement of	24
were incubated with	24
be recognized by	24
this type of	24
expression of il	24
addition to the	24
is an essential	24
the application of	24
of the mouse	24
in the t	24
be responsible for	24
the spread of	24
mice with a	24
leads to a	24
we demonstrated that	24
expression on astrocytes	24
the association of	24
we have found	24
regulation of mhc	24
associated with increased	24
of innate immune	24
access to the	24
in dendritic cells	24
performed using the	24
may be involved	24
of infected cells	24
data demonstrate that	24
to increase the	24
significant increase in	24
than in the	24
for their ability	24
the form of	24
a wide variety	24
into the cns	24
th and th	24
produced by the	24
from the cell	24
are consistent with	24
class ii drb	24
bone marrow cells	24
in the design	24
are the most	24
l l s	24
the quality of	24
a significant increase	24
it is important	24
from the endoplasmic	24
mechanisms by which	24
a comparison of	24
not yet been	24
the efficiency of	24
the seminiferous epithelium	24
reduction of the	23
that could be	23
were present in	23
b cell epitope	23
lead to a	23
context of the	23
is independent of	23
is likely that	23
interaction of the	23
and t cells	23
the ratio of	23
of peripheral blood	23
as determined by	23
intercellular adhesion molecule	23
type i interferon	23
be related to	23
i heavy chain	23
cells infected with	23
a t i	23
not appear to	23
strains of mice	23
from the same	23
experimental autoimmune encephalomyelitis	23
directed against the	23
was defined as	23
of t lymphocytes	23
of a large	23
as early as	23
for h at	23
epitopes derived from	23
a range of	23
effects of the	23
peripheral blood lymphocytes	23
it can be	23
in cd t	23
nitric oxide synthase	23
due to their	23
prediction of the	23
macrophages and dendritic	23
based peptide vaccine	23
human peripheral blood	23
prediction of mhc	23
for vaccine development	23
located in the	23
a and a	23
t cell population	23
for the mhc	23
cellular immune response	23
acute and chronic	23
the peptide binding	23
is important for	23
of the predicted	23
clones specific for	23
b cell receptor	23
is critical for	23
expression of these	23
work was supported	23
patients with a	23
important for the	23
of gd t	23
of a peptide	23
account for the	23
resulting in a	23
has been found	23
of these peptides	23
transported to the	23
of dengue virus	23
serum levels of	23
the first step	23
the t cells	23
cd cd cells	23
of the binding	23
and cytokine production	23
w i t	23
effect of the	23
i antigen processing	23
be important for	23
in comparison with	23
the size of	23
level of the	23
class i restricted	23
is likely to	23
absence of the	23
to have a	23
well as a	23
due to its	23
western blot analysis	23
immune responses against	23
cellular and humoral	23
indicating that the	23
programmed cell death	23
increased in the	23
the prevention of	22
been found to	22
l dna constructs	22
along with the	22
web server for	22
mouse model of	22
inflammation in the	22
bvd vaccinated dams	22
immune response and	22
within the first	22
the sertoli cell	22
cell surface molecules	22
the stability of	22
of a protein	22
immune system is	22
comparison of the	22
to examine the	22
one or two	22
infected with a	22
in these mice	22
of these molecules	22
of inkt cells	22
human mhc class	22
the e protein	22
may have a	22
of virus infection	22
in the field	22
class ii gene	22
for vaccine design	22
for further analysis	22
can bind to	22
their capacity to	22
cellular immune responses	22
increased levels of	22
and may be	22
t lymphocytes in	22
b cells are	22
specific immune responses	22
for the presence	22
of natural killer	22
of the e	22
was significantly lower	22
and the number	22
of the n	22
to viral infection	22
the united states	22
the emergence of	22
diversity of the	22
is not a	22
a role of	22
and it is	22
there were no	22
major role in	22
correlated with the	22
g and il	22
cd t lymphocyte	22
is that the	22
is necessary for	22
were measured by	22
the stimulation of	22
with the hla	22
induction of the	22
to class i	22
virus infection in	22
was based on	22
binds to the	22
of the blood	22
levels of the	22
transforming growth factor	22
the presence or	22
are expressed in	22
of immune cells	22
by cytotoxic t	22
the most important	22
in the study	22
a decrease in	22
and development of	22
domain of the	22
class i haplotypes	22
cytokines and chemokines	22
reduction in the	22
the human genome	22
restricted t cell	22
pattern recognition receptors	22
expression of genes	22
dengue hemorrhagic fever	22
referred to as	22
production of the	22
plays a role	22
in the last	22
chicken mhc class	22
for binding to	22
been detected in	22
formation of the	22
in the heart	22
development of the	22
immune responses by	22
were tested for	22
peptides in the	22
position of the	21
that has been	21
the appearance of	21
the delivery of	21
of a novel	21
length of the	21
any of the	21
proteins that are	21
of the other	21
the potential of	21
the most frequent	21
has been identified	21
of an epitope	21
of the target	21
based on their	21
in complex with	21
its ability to	21
the virus to	21
in the lung	21
needs to be	21
epitopes of the	21
mycobacterium avium subsp	21
to the cns	21
in this review	21
in the bone	21
aspects of the	21
and cd cd	21
is not clear	21
viruses such as	21
independent of the	21
are found in	21
of these two	21
that had been	21
by a single	21
were cultured in	21
evolution of the	21
in the skin	21
by the presence	21
induction of mhc	21
class i surface	21
response of the	21
that cd t	21
morbidity and mortality	21
mechanisms involved in	21
of cd a	21
was present in	21
more likely to	21
these data indicate	21
the in vitro	21
highest binding affinity	21
of at least	21
the significance of	21
of viral infections	21
natural killer cell	21
secretion of il	21
under the control	21
have developed a	21
of the murine	21
levels in the	21
cells with a	21
dimensional structure of	21
a high level	21
of nk cells	21
but not by	21
in the future	21
cell antigen receptor	21
database and analysis	21
to the b	21
is capable of	21
positional bias of	21
development of bnp	21
compared to controls	21
proteins involved in	21
for the identification	21
this study is	21
t cells recognize	21
predicted to be	21
crucial role in	21
male reproductive tract	21
expressed on the	21
of the transgene	21
compared to non	21
we used a	21
of genetic diversity	21
insight into the	21
interaction between the	21
of the study	21
that it is	21
we are currently	21
investigate the role	21
epitopes in the	21
the development and	21
correlation between the	21
the nervous system	21
reactive oxygen species	21
proteins from the	21
of amino acid	21
in c bl	21
of the selected	21
a major role	21
as a major	21
a reduction in	21
t cell hybridomas	21
with and without	21
were observed in	21
led to a	21
results of the	21
of the mechanisms	21
able to recognize	21
a model of	20
is caused by	20
production of ifn	20
in our study	20
is present in	20
com scientificreports www	20
to compare the	20
for each of	20
of the gene	20
are characterized by	20
in the form	20
transfection effi ciency	20
are believed to	20
indicated that the	20
ii mhc molecules	20
of a single	20
the transcription factor	20
be an important	20
the cell membrane	20
is expressed on	20
to be important	20
the male reproductive	20
expression of h	20
diversity in the	20
when compared with	20
these cells are	20
in all patients	20
bvd vaccinated non	20
a dna vaccine	20
class i or	20
institutes of health	20
depend on the	20
described in the	20
of the inflammatory	20
cells that are	20
bnp and bnp	20
these results indicate	20
of the c	20
for this purpose	20
is expressed in	20
which has been	20
specific cd and	20
status of the	20
a pivotal role	20
infection of the	20
of influenza virus	20
of acute rejection	20
infectious virus release	20
were analyzed using	20
on t cell	20
many of these	20
as part of	20
quality of the	20
the interaction with	20
did not affect	20
compared to that	20
for min at	20
the authors declare	20
and analysis resource	20
e ubiquitin ligase	20
the extent of	20
were included in	20
were used for	20
and mhc ii	20
both mhc class	20
cells such as	20
of all the	20
of balb c	20
binding affinity of	20
mutations in the	20
helper t cells	20
role of cd	20
of the four	20
immune system in	20
participate in the	20
t cell line	20
it is known	20
the prevalence of	20
key role in	20
important in the	20
t cell tolerance	20
the field of	20
a single amino	20
of the different	20
health and disease	20
of dna vaccines	20
we studied the	20
is produced by	20
vivo and in	20
were analyzed for	20
the h n	20
evidence for a	20
in the serum	20
virus in the	20
no significant difference	20
for class ii	20
it was shown	20
derived from a	20
differences between the	20
molecular mechanisms of	20
that these cells	20
affinity to the	20
their role in	20
of bone marrow	20
the most potent	20
corresponding to the	20
has been observed	20
retrieved from the	20
with antigen presentation	20
be induced by	20
origin rhesus macaques	20
added to the	20
serve as a	20
of cd cells	20
shown to induce	20
peptides binding to	20
can be found	20
and nk cells	20
restricted cytotoxic t	20
to have the	20
cells in response	20
of the chicken	19
to address the	19
the innate and	19
will be discussed	19
sensitivity and specificity	19
and of the	19
of plasmid dna	19
the evolution of	19
believed to be	19
tap and tap	19
the strength of	19
cells play a	19
ii presentation of	19
in vitro studies	19
activation of cd	19
of the molecular	19
t cell antigen	19
is similar to	19
to induce a	19
to develop a	19
antigen in the	19
more than of	19
has shown that	19
it may be	19
tested for their	19
with the human	19
and the presence	19
we propose that	19
in the cd	19
resulting in the	19
and the immune	19
to generate a	19
linked to the	19
for induction of	19
human t cells	19
cells but not	19
cd cd foxp	19
effects of ifn	19
with a high	19
the consequences of	19
into the er	19
involved in antigen	19
antigen recognition by	19
portion of the	19
recognition of a	19
were retrieved from	19
first line of	19
plasmacytoid dendritic cells	19
it is now	19
of the ctl	19
were stained with	19
of the testis	19
similar results were	19
conformation of the	19
evidence for the	19
the objective of	19
using flow cytometry	19
a source of	19
cells were stimulated	19
in renal transplant	19
the er and	19
been identified in	19
it is the	19
cell epitopes were	19
which may be	19
in the graft	19
known about the	19
we observed a	19
of regulatory t	19
of the v	19
national institutes of	19
immune system to	19
the cns of	19
occur in the	19
was to investigate	19
analysis was performed	19
cell response in	19
we did not	19
we have investigated	19
in a mouse	19
astrocytes and microglia	19
responses to the	19
the antibody response	19
has recently been	19
pivotal role in	19
were significantly higher	19
of the s	19
b cells in	19
for antigen presentation	19
a murine model	19
we have demonstrated	19
to the pathogenesis	19
in the united	19
igg and igg	19
genes in the	19
in health and	19
by western blot	19
be used in	19
mice were immunized	19
were infected with	19
a function of	19
are thought to	19
the dna vaccine	19
used to predict	19
in this model	19
in a number	19
b and c	19
risk factors for	19
was not significantly	19
nielsen et al	19
but not the	19
have found that	19
positive and negative	19
epitopes that are	19
is a common	19
in more detail	19
and bone marrow	19
to our knowledge	19
class i gene	19
i molecules and	19
with the amino	19
structure and function	19
of the three	19
difference in the	19
was evaluated by	19
the increase in	19
thymic epithelial cells	19
of influenza a	18
and treatment of	18
levels of ifn	18
order to determine	18
of both the	18
vesicular stomatitis virus	18
of which are	18
of the proteins	18
of the best	18
mice treated with	18
in b cell	18
elevated levels of	18
class i pathway	18
we were able	18
for at least	18
a rise in	18
antigen expression in	18
t cell differentiation	18
indicates that the	18
specific immune response	18
evaluation of the	18
it is a	18
processing of the	18
used to determine	18
emerging infectious diseases	18
higher in the	18
in mammalian cells	18
mediated immune response	18
cd cells were	18
in the past	18
the origin of	18
and natural killer	18
a review of	18
seem to be	18
cells with the	18
of these proteins	18
could be detected	18
by the addition	18
prior to the	18
majority of the	18
belonging to the	18
in the peptide	18
the population coverage	18
results were obtained	18
have been found	18
during the course	18
variation in the	18
may be due	18
of autoimmune diseases	18
under normal conditions	18
together with the	18
our results suggest	18
in the process	18
by the use	18
better understanding of	18
we aimed to	18
number of cd	18
not due to	18
i n t	18
can result in	18
are important for	18
to test this	18
lymph node cells	18
the complexity of	18
capacity of the	18
our results show	18
the expansion of	18
foxp t cells	18
protein in the	18
the establishment of	18
peripheral blood of	18
a significantly higher	18
different types of	18
rather than the	18
are responsible for	18
er quality control	18
t e r	18
stages of the	18
there are no	18
as a novel	18
protective immunity against	18
t cell help	18
the transfer of	18
but it is	18
are needed to	18
and major histocompatibility	18
and has been	18
consistent with a	18
i mhc antigen	18
mouse and human	18
to explain the	18
result in a	18
not able to	18
population coverage of	18
comparison to the	18
of ebola virus	18
analysis showed that	18
followed by a	18
potential role of	18
are currently being	18
in antigen processing	18
in kidney transplant	18
after kidney transplantation	18
in spite of	18
the human mhc	18
the autophagy machinery	18
has been implicated	18
cell clones specific	18
express class ii	18
amino acid substitutions	18
ischemia reperfusion injury	18
was dependent on	18
of innate immunity	18
in vivo in	18
be activated by	18
a high degree	18
interact with the	18
pred balb c	18
humoral and cellular	18
peptide vaccine against	18
was found that	18
which in turn	18
do not express	18
roles in the	18
presence of il	18
that in the	18
immune response of	18
on the presence	18
that do not	18
in vitro with	18
protein data bank	18
carried out in	18
of the bat	17
shown to have	17
a server for	17
not required for	17
significantly lower in	17
identified as a	17
such as tnf	17
the control group	17
be mediated by	17
of c d	17
based on these	17
be detected in	17
were determined using	17
is related to	17
the antigen presentation	17
a n s	17
mice vaccinated with	17
parts of the	17
critical for the	17
response to infection	17
recognition of the	17
proved to be	17
subunit of the	17
ii expressing cells	17
of the interaction	17
association with the	17
of a given	17
that observed in	17
importance of the	17
induction of autophagy	17
have been implicated	17
were performed in	17
mhc i and	17
studies of the	17
samples were collected	17
were identified by	17
cytokine production by	17
for up to	17
structure of a	17
n a l	17
ability to induce	17
and have been	17
determined by flow	17
class i in	17
of apoptotic cells	17
been suggested that	17
type i and	17
cells are not	17
responses in the	17
type i ifns	17
only a few	17
t cell immunity	17
compared to those	17
used to identify	17
to the host	17
immune response is	17
amino acid composition	17
of chronic rejection	17
and the development	17
epitopes can be	17
and h n	17
to elucidate the	17
the numbers of	17
which have been	17
been identified as	17
the human cytomegalovirus	17
basis of the	17
can be detected	17
i molecules are	17
university school of	17
an mhc class	17
in silico analysis	17
to facilitate the	17
cells derived from	17
have been proposed	17
of hepatitis c	17
on their surface	17
by b cells	17
to better understand	17
r a n	17
structural basis for	17
respect to the	17
has been associated	17
to improve the	17
is a highly	17
was obtained from	17
had the highest	17
of the hiv	17
to be an	17
deletion of the	17
delayed graft function	17
of b m	17
significant difference in	17
genes of the	17
helper t cell	17
the total number	17
the draining lymph	17
were assessed by	17
proteins of the	17
could lead to	17
cell epitopes for	17
cell death in	17
we found a	17
to be determined	17
to major histocompatibility	17
to cytotoxic t	17
different cell types	17
the bat transcriptome	17
the availability of	17
molecules such as	17
in human and	17
of a t	17
an analysis of	17
are based on	17
findings indicate that	17
infection of human	17
are derived from	17
that they are	17
capable of inducing	17
antigens in the	17
are recognized by	17
virus replication in	17
and bnp dams	17
in the initiation	17
cells and b	17
between the groups	17
antigen expression by	17
the two groups	17
were collected from	17
use of a	17
to the hla	17
were positive for	17
has led to	17
cells by the	17
regulation of class	17
to inhibit the	17
may be an	17
by the t	17
at the is	17
to the t	17
cells transfected with	17
the processing of	17
the cytotoxic t	17
focus on the	17
f o r	17
it appears that	17
here we show	17
function as a	17
of the total	17
the structures of	17
absence of cd	17
expression in astrocytes	17
that t cells	17
the a and	17
and antigen presentation	17
cd cytotoxic t	17
is necessary to	17
in their ability	17
in a murine	17
the introduction of	17
an overview of	17
role of autophagy	16
epitopes have been	16
was due to	16
the current study	16
large amounts of	16
p and p	16
was followed by	16
the first year	16
t cells of	16
by at least	16
from peripheral blood	16
molecular basis of	16
broad range of	16
for treatment of	16
be useful in	16
murine class i	16
development of an	16
has to be	16
were used in	16
a cohort of	16
mechanism for the	16
interferon regulatory factor	16
a link between	16
remain to be	16
and l dna	16
and do not	16
in the h	16
been demonstrated in	16
the target cells	16
the mhc ii	16
antigen presentation in	16
was no significant	16
implications for the	16
to enhance the	16
indian rhesus macaques	16
were unable to	16
middle east respiratory	16
be important in	16
expression levels of	16
basis for the	16
this may be	16
the sequences of	16
cell and b	16
of the entire	16
have been associated	16
lee et al	16
data from the	16
i expression by	16
there are many	16
a cd t	16
of adhesion molecules	16
the clearance of	16
are produced by	16
have the potential	16
dependent rna polymerase	16
the mhc molecule	16
as opposed to	16
cells to the	16
the replication of	16
specific for a	16
analyses were performed	16
is accompanied by	16
recognized by t	16
of bat mhc	16
cells stimulated with	16
from balb c	16
for patients with	16
t cells as	16
in this case	16
activation and proliferation	16
well as to	16
of the response	16
peptides bound to	16
domains of the	16
findings suggest that	16
the university of	16
cell epitopes from	16
of molecular mimicry	16
result of the	16
the list of	16
simian immunodeficiency virus	16
spleen cells from	16
t c e	16
response to viral	16
bind to mhc	16
of myelin basic	16
study is to	16
to the nucleus	16
with a single	16
entry into the	16
in human t	16
the spike peptide	16
which could be	16
the characterization of	16
c mice were	16
respiratory syncytial virus	16
affinity of the	16
as shown by	16
a and il	16
and patient survival	16
recent studies have	16
be found in	16
to be able	16
there are several	16
of the present	16
patients and healthy	16
the roles of	16
viral and bacterial	16
immunogenicity of a	16
chen et al	16
a limited number	16
in the course	16
inducible nitric oxide	16
necessary for the	16
infected with the	16
in accordance with	16
recipients of a	16
and cd cells	16
risk factor for	16
can be activated	16
in the hla	16
impact on the	16
was shown that	16
suggested that the	16
the cns is	16
encoded by the	16
i binding prediction	16
the immunological synapse	16
presentation of peptides	16
with the highest	16
t cells or	16
are susceptible to	16
of the complex	16
overview of the	16
mice and humans	16
in most cases	16
is induced by	16
but also the	16
and the mhc	16
the exception of	16
early stages of	16
t cell function	16
the peptides were	16
e n t	16
oligodendrocytes and astrocytes	16
molecules involved in	16
i antigen expression	16
characterization of a	16
evidence suggests that	16
mhc antigens on	16
naive and memory	16
of peptides to	16
for the hla	16
human cytomegalovirus us	16
significantly increased in	16
we tested the	16
measured by elisa	16
e c t	16
our results indicate	16
is a complex	16
to t cell	16
as in the	16
used as the	16
positive correlation between	16
which leads to	16
the concentration of	16
may be more	16
mediated immune responses	16
are required to	16
can interact with	16
in the current	16
as assessed by	16
the balb c	16
expression on the	16
and humoral immune	16
mhc molecules in	16
regardless of the	16
and proliferation of	16
the goal of	16
both innate and	16
are critical for	16
on cd t	16
selection of ctl	16
and found that	16
epitope database and	16
no significant differences	16
east respiratory syndrome	16
murine model of	16
host immune system	16
in mice infected	16
and specificity of	16
induced class ii	16
a better understanding	16
is sufficient to	16
cells isolated from	16
cells into the	16
is not required	16
vaccines have been	16
generated by the	16
epitopes for the	15
and could be	15
which are involved	15
will be presented	15
to this end	15
lower levels of	15
decrease in the	15
of the endoplasmic	15
cell surface and	15
t lymphocytes and	15
is known that	15
terms of the	15
small number of	15
process and present	15
they do not	15
which is associated	15
can be seen	15
dendritic cells are	15
of memory t	15
the immune responses	15
using the iedb	15
supplementary table s	15
have the highest	15
the genome of	15
is important in	15
tumour necrosis factor	15
were immunized with	15
feature of the	15
are available for	15
alleles of the	15
which results in	15
of mhc antigens	15
treatment with anti	15
the last decade	15
world health organization	15
such as cd	15
cells and t	15
in v i	15
range of pathogens	15
and is a	15
they can be	15
is composed of	15
infection of mice	15
a pool of	15
for the same	15
role in regulating	15
of the world	15
the most polymorphic	15
positive selection of	15
an animal model	15
hematopoietic stem cells	15
a and c	15
multiple sclerosis lesions	15
papillomavirus type e	15
step in the	15
there is evidence	15
a positive correlation	15
class ii expressing	15
from the national	15
after the last	15
higher than that	15
line of defense	15
in recent years	15
and at the	15
sequence analysis of	15
identification and characterization	15
a broad range	15
different strains of	15
the dynamics of	15
the sertoli cells	15
antibody response to	15
the secretory pathway	15
expansion of the	15
manipulation of the	15
number of different	15
role for autophagy	15
cells and their	15
an in silico	15
may be important	15
at a single	15
aim of the	15
the cellular immune	15
but also in	15
to address this	15
the notion that	15
we have also	15
gene expression and	15
that class i	15
is the major	15
signal transduction pathways	15
vast majority of	15
multiple sequence alignment	15
was detected by	15
of herpes simplex	15
is a potent	15
stimulation of the	15
we have studied	15
better understand the	15
this is not	15
and cd a	15
d structure of	15
influenza a viruses	15
cell lines were	15
antibody mediated rejection	15
has the potential	15
to the peptide	15
did not differ	15
it is clear	15
within the cell	15
give rise to	15
cells were then	15
a reduction of	15
in the b	15
t h i	15
in situ hybridization	15
mice with the	15
to dendritic cells	15
of dna vaccine	15
in class i	15
is derived from	15
their interaction with	15
the age of	15
constitutive expression of	15
the first months	15
and analysis of	15
zhou et al	15
the frequencies of	15
c d deposition	15
available in the	15
with more than	15
cell epitope predictions	15
class ii and	15
of severe acute	15
to form a	15
expression of major	15
wild type mice	15
at least three	15
cells has been	15
of the epitopes	15
we report the	15
b m deficient	15
of inflammatory cells	15
in innate immunity	15
complex with the	15
to define the	15
t cells expressing	15
r e s	15
not detected in	15
it is unclear	15
to be elucidated	15
acid sequence of	15
as described in	15
been reported that	15
and or the	15
wu et al	15
a loss of	15
was expressed in	15
and tumor necrosis	15
in a similar	15
may be the	15
were measured in	15
dislocation from the	15
of a vaccine	15
cells and in	15
donor and recipient	15
the s proteasome	15
was observed for	15
the patients with	15
compared to a	15
significantly reduced in	15
mechanism of action	15
large numbers of	15
cell death and	15
and did not	15
in cases of	15
by treatment with	15
express class i	15
by expression of	15
be required for	15
treatment with ifn	15
not in the	15
is found in	15
were compared to	15
different stages of	15
the choice of	15
the understanding of	15
presence of ifn	15
the antigen processing	15
the s protein	15
regulated by the	15
determine whether the	15
in class ii	15
targeted to the	15
play a critical	15
is required to	15
absence of any	15
was analyzed using	15
b and b	15
cytokine production and	15
mrna expression in	15
belong to the	15
but not of	15
was inhibited by	15
were generated by	15
was added to	15
i molecules in	15
purpose of this	15
in the peripheral	15
to the activation	15
of viral replication	15
in the cell	15
treatment of the	15
by the sertoli	15
and the expression	15
results from the	15
was increased in	15
expressing cells in	15
in the antigen	15
allowed us to	15
nk cells and	15
are included in	14
be attributed to	14
it should be	14
graft survival in	14
of viral infection	14
of the genome	14
in these animals	14
we describe the	14
study demonstrates that	14
or more of	14
and igg a	14
is predicted to	14
prediction of peptide	14
candidate subunit vaccines	14
in animal models	14
to virus infection	14
that expression of	14
gd t cell	14
in silico approach	14
artificial neural network	14
evidence that the	14
followed by the	14
might be a	14
role for cd	14
cells and macrophages	14
in a given	14
present study was	14
of mast cells	14
cell surface receptors	14
of the tumor	14
not only to	14
in these patients	14
department of immunology	14
of a virus	14
to confirm the	14
of the individual	14
loss of the	14
caused by a	14
at the c	14
of the designed	14
virus infection and	14
peptides from the	14
to a large	14
the location of	14
cd cd t	14
the requirement for	14
class ii transactivator	14
recombinant vaccinia virus	14
in at least	14
processes such as	14
to explore the	14
a significant reduction	14
of the recipients	14
numbers of cd	14
up to of	14
v i m	14
was no difference	14
in all groups	14
of the receptor	14
were subjected to	14
endothelial cells and	14
and suggest that	14
our data show	14
at the site	14
to reduce the	14
of in vitro	14
cell epitopes are	14
epitopes from the	14
were predicted by	14
peptides that can	14
to a single	14
necrosis factor alpha	14
the persistence of	14
of genetic variation	14
by limiting dilution	14
cell proliferation in	14
t cell populations	14
by using the	14
brown et al	14
but not to	14
number of peptides	14
in the bat	14
unfolded protein response	14
and production of	14
were analysed by	14
on the expression	14