quadgram

This is a table of type quadgram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

quadgram frequency
severe acute respiratory syndrome1179
in the presence of1006
acute respiratory syndrome coronavirus711
on the other hand598
in the case of579
has been shown to533
in the absence of523
as well as the511
is one of the437
an important role in432
one of the most374
in vitro and in366
was found to be347
of severe acute respiratory338
vitro and in vivo336
in the present study335
on the surface of331
can be used to329
have been shown to324
in the context of321
in the regulation of319
for the development of317
on the basis of310
for the treatment of309
a wide range of306
the aim of this293
play a role in270
in the development of270
been shown to be258
of this study was255
the severe acute respiratory255
as well as in251
it has been shown250
the structure of the249
human immunodeficiency virus type248
aim of this study242
as a result of240
middle east respiratory syndrome239
a large number of236
this study was to230
at the same time229
in addition to the228
play an important role227
the presence of the227
were found to be226
to be involved in225
has been shown that216
for the first time215
the presence of a210
the role of the209
for the production of204
porcine epidemic diarrhea virus203
the end of the201
in the formation of199
work was supported by198
this work was supported197
the central nervous system196
plays an important role195
the surface of the191
in the pathogenesis of188
east respiratory syndrome coronavirus182
it is important to177
the formation of the177
it was found that175
to the cell surface174
the expression of the174
at the end of172
a key role in171
we were able to170
a member of the167
in this study we166
herpes simplex virus type164
of hepatitis c virus163
r o o f161
l p r e161
o u r n161
u r n a161
it was shown that161
n a l p161
p r o o161
a l p r161
j o u r161
r n a l161
in the treatment of160
are involved in the159
to the plasma membrane159
it is possible to156
important role in the155
these results suggest that154
is based on the153
it is possible that153
in the form of149
is involved in the146
of the s protein146
a role in the145
of the spike protein144
be involved in the143
the formation of a138
can be used for138
for the detection of138
was shown to be137
a crucial role in135
little is known about134
to the formation of134
to the development of133
we found that the133
in contrast to the132
has been reported to132
of the n protein130
as a function of130
with respect to the130
the nature of the129
of herpes simplex virus129
is required for the128
by the presence of128
studies have shown that127
as shown in fig127
of human immunodeficiency virus127
the crystal structure of126
can be used as125
it has been suggested125
the aim of the125
similar to that of124
on the cell surface123
the development of a123
crystal structure of the123
in the endoplasmic reticulum122
for the identification of120
under the control of120
at the level of119
as well as a118
to that of the118
was supported by the118
the function of the117
has been suggested that116
the present study was116
of the sars coronavirus115
a better understanding of114
of the amino acid114
the size of the114
plays a role in113
the effect of the113
for the synthesis of113
pseudo amino acid composition113
a critical role in113
has been used to112
a wide variety of112
the amino acid sequence112
it is known that112
in a variety of111
may be involved in111
at the time of111
the activation of the110
our understanding of the110
structure and function of109
to be associated with109
the ability of the108
the hepatitis c virus108
of the severe acute108
have been used to107
at the cell surface107
in the range of106
was used as a106
and characterization of a106
the results showed that106
the case of the105
coronavirus infectious bronchitis virus105
we have shown that105
the activity of the104
in the field of104
the majority of the104
is a member of104
an increase in the103
in the production of103
identification and characterization of103
at the plasma membrane102
one of the major102
can be found in102
a central role in100
the stability of the100
of the present study100
in vivo and in99
for the formation of99
our results show that98
the fact that the98
results suggest that the98
the analysis of the98
of this study is98
have shown that the97
our results suggest that97
is known about the97
in the process of96
in the control of96
the interaction of the96
the development of the95
it is likely that95
is thought to be95
of amino acid residues95
is responsible for the95
in the course of95
in a number of95
with severe acute respiratory94
it should be noted94
of porcine epidemic diarrhea93
is known to be93
is consistent with the92
the regulation of the92
the binding of the92
these results indicate that92
in the central nervous92
the nucleocapsid protein of91
study was to investigate91
presence or absence of91
of the immune system91
of the plasma membrane91
be used as a91
a major role in91
the basis of the90
of mouse hepatitis virus90
the results of the90
it has been reported89
as well as to89
to the presence of89
better understanding of the89
for the presence of89
as compared to the89
involved in the regulation89
as a consequence of88
vivo and in vitro88
of influenza a virus88
mechanism of action of88
with the use of88
the length of the88
the total number of88
it has been proposed87
isolation and characterization of87
to interact with the87
the rest of the87
these data suggest that87
in the present work87
both in vitro and86
that can be used86
the molecular basis of86
for the design of86
in the expression of86
of the viral genome86
of the m protein85
this is the first85
are known to be84
our results indicate that84
amino acid sequence of84
the control of the84
the use of the84
is essential for the83
the interaction between the83
the protein data bank83
the unfolded protein response83
of the target protein82
was to investigate the82
should be noted that82
as well as for82
by the addition of82
the presence or absence82
in the number of82
the active site of81
may contribute to the81
the lumen of the81
of reactive oxygen species81
from the endoplasmic reticulum81
the innate immune system81
were shown to be80
has been found to80
is likely to be80
the use of a79
has been proposed that79
a significant increase in79
epidermal growth factor receptor79
the innate immune response79
of a number of79
by the use of79
of the innate immune79
have been reported to78
this study is to78
is associated with the78
is supported by the78
a high degree of78
of semliki forest virus78
the mechanism by which78
for the analysis of77
the development of novel77
has been reported that77
the development of new77
the spike protein of77
our data suggest that77
for the generation of76
the context of the76
the mechanism of action76
is mediated by the76
in this work we76
we have developed a76
the purpose of this76
play important roles in75
the importance of the75
to the fact that75
in order to determine75
of vesicular stomatitis virus75
have been found to75
and function of the75
porcine reproductive and respiratory75
the viral life cycle75
in a mouse model75
was added to the74
in cells infected with74
the human immunodeficiency virus74
reproductive and respiratory syndrome74
an essential role in74
of the endoplasmic reticulum74
cells were treated with74
been found to be73
the identification of the73
in the united states73
also been shown to73
in order to identify73
used in this study73
aim of the present73
it has been demonstrated72
play a crucial role72
on the use of72
present study was to72
plays a key role72
of the host cell71
has been implicated in71
of the immune response71
we show that the71
of a variety of71
in the plasma membrane71
cd and cd t71
of the most important71
and respiratory syndrome virus71
the effects of the71
as shown in figure70
to be able to70
shown to interact with70
one of the main70
the aim of our70
it is clear that70
study was supported by70
for each of the70
used to determine the70
the plasma membrane and69
african swine fever virus69
for the study of69
to the identification of69
play a key role69
the expression levels of69
may play a role69
may be due to69
have been identified in69
we have investigated the69
has been demonstrated that68
by the fact that68
the sequence of the68
results showed that the68
peripheral blood mononuclear cells67
the presence of an67
has also been shown67
was observed in the67
hepatitis c virus core67
the cytoplasmic domain of67
in the design of67
be due to the67
be responsible for the67
that are involved in66
in the cytoplasm of66
assisted laser desorption ionization66
during the course of66
the secondary structure of66
on the presence of66
well as in the66
is due to the66
been reported to be66
that there is a65
at the site of65
for the prediction of65
to play a role65
than that of the65
with the exception of64
was used as the64
of hepatitis b virus64
are likely to be64
the authors declare no64
the influence of the64
is important for the64
can be used in64
with the help of64
to the lack of64
in the host cell64
had no effect on63
the expression level of63
results indicate that the63
as one of the63
washed three times with63
proteins involved in the62
characterization of a novel62
amino acid sequences of62
that the presence of62
involved in the formation62
it is necessary to62
could be used to62
it has also been62
the plasma membrane of62
at the surface of62
structural basis for the62
cells were infected with61
by western blot analysis61
structure of the protein61
no conflict of interest61
h at room temperature61
the vast majority of61
innate and adaptive immune61
in the current study61
has the potential to61
the protein of interest61
the results suggest that61
a pivotal role in60
as part of the60
in the identification of60
on the role of60
of the central nervous60
the nuclear pore complex60
is not required for60
in order to investigate60
is dependent on the60
role in the regulation60
a result of the60
vascular endothelial growth factor60
be related to the60
the s protein of60
investigate the role of60
for the induction of59
it is well known59
for h at room59
the host immune response59
the cytoplasmic tail of59
a broad range of59
the study of the59
of the role of59
due to the lack59
we have previously shown59
for their ability to59
min at room temperature59
to be responsible for59
as well as by58
been shown that the58
solid phase peptide synthesis58
internal ribosome entry site58
when compared to the58
the molecular mechanisms of58
are responsible for the58
have been developed to58
in agreement with the58
results show that the58
acute respiratory distress syndrome58
in the presence or58
these findings suggest that57
plays a crucial role57
with the aim of57
the subcellular localization of57
into the host cell57
the present study we57
the results show that57
was found that the56
incubated for h at56
in the golgi apparatus56
and cd t cells56
to an increase in56
in accordance with the56
the synthesis of the56
for min at room56
can be applied to56
as well as their56
is well known that56
respiratory syndrome coronavirus spike56
of a novel coronavirus56
a significant role in56
key role in the56
for the expression of56
has not yet been56
we have found that56
can also be used55
a decrease in the55
in health and disease55
is shown in figure55
and the role of55
the early stages of55
the coronavirus infectious bronchitis55
the authors declare that55
identification of a novel55
be used for the55
major histocompatibility complex class55
class ii fusion proteins55
the structure and function54
crucial role in the54
sars coronavirus nucleocapsid protein54
human respiratory syncytial virus54
to better understand the54
plays a central role54
proteins are involved in54
c virus core protein54
the results of this54
a new class of54
investigate the effect of54
have been implicated in54
a component of the54
is associated with a54
similar to those of53
and the presence of53
are listed in table53
of the secretory pathway53
has been proposed to53
to the golgi complex53
and the development of53
in the generation of53
a negative regulator of53
nucleotide sequence of the53
production of recombinant proteins53
our results showed that53
is shown in fig53
to investigate the effect53
to be important for53
in terms of the53
as a source of53
the assembly of the53
at room temperature for53
have previously shown that53
the quality of the53
of the golgi apparatus53
the expression of a53
the mechanisms by which53
been shown to interact52
play a critical role52
in order to study52
the d structure of52
amino acids in the52
revealed the presence of52
compared to the control52
the existence of a52
of the fusion protein52
of the e protein52
and the number of52
on the one hand52
is predicted to be52
cells were transfected with52
plays a critical role52
is the most common52
to be the most52
is considered to be52
of the most common52
have the potential to52
a broad spectrum of51
was used for the51
have been developed for51
terminal domain of the51
in the nucleus and51
be one of the51
evs were isolated from51
the influenza a virus51
it is difficult to51
to the use of51
of the influenza virus51
has been identified as51
can be divided into51
a limited number of51
in a wide range51
was carried out by51
on the development of51
and is required for50
amino acid residues in50
been implicated in the50
of middle east respiratory50
are present in the50
was carried out using50
would like to thank50
the first time that50
it is interesting to50
the absence of the50
is present in the50
in the activation of50
it was observed that50
the changes in the50
the s protein is50
can be considered as50
on the expression of50
of infectious bronchitis virus50
that are able to50
to be used in50
was used to determine50
the most commonly used50
is believed to be50
we would like to50
of cd t cells50
may serve as a50
have been associated with49
orf a and orf49
to be essential for49
the results indicate that49
the amino acid sequences49
to investigate the role49
by nanoparticle tracking analysis49
in the synthesis of49
and functional analysis of49
play a major role49
were used for the49
is the number of49
is related to the49
have been identified as49
to the surface of49
the host immune system49
the specificity of the49
avian infectious bronchitis virus49
have not yet been49
these results demonstrate that49
at the molecular level49
through the use of49
at a concentration of48
could be used for48
is similar to that48
in the spike protein48
critical role in the48
is part of the48
hepatitis c virus infection48
the transmembrane domain of48
in the near future48
aim of our study48
used to study the48
the molecular mechanism of48
have the ability to48
we have studied the48
and it has been48
associated with severe acute48
for the preparation of48
coronavirus mouse hepatitis virus48
other members of the48
terminal region of the48
is found to be48
its interaction with the48
of the amino acids48
it is not clear48
the synthesis of a48
here we show that47
this study was supported47
and characterization of the47
to the production of47
higher than that of47
were washed three times47
are required for the47
that they have no47
in the active site47
as in the case47
structure of the sars47
the biological activity of47
for the purpose of47
analysis was performed using47
data suggest that the47
a small number of47
the cell surface and47
investigated the effect of47
the determination of the47
that the majority of47
of this work was47
that the expression of47
in order to obtain47
using a combination of47
it was demonstrated that47
in the cytoplasm and46
could be used as46
in the vicinity of46
the course of the46
has been associated with46
at different time points46
is required for efficient46
protein of severe acute46
play an essential role46
due to the fact46
amino acids of the46
the formation of an46
which are involved in46
the understanding of the46
and its role in46
eukaryotic translation initiation factor46
presence and absence of46
the life cycle of46
with the plasma membrane46
role in the pathogenesis46
shown to be a46
the n protein of46
in the study of46
terminal part of the46
study the effect of46
has also been reported46
was performed using the46
in response to the46
it remains to be46
the level of the45
be considered as a45
are considered to be45
of the interaction of45
new insights into the45
shed light on the45
of the cell cycle45
from the er to45
to be required for45
in comparison to the45
mhc class i molecules45
been shown to have45
our aim was to45
the production of recombinant45
of the structure of45
as well as with45
to the activation of45
the position of the45
declare that they have45
the inhibitory effect of45
the causative agent of45
a functional receptor for45
the hepatitis b virus45
binding domain of the45
of the protein is45
small cell lung cancer45
and functional characterization of45
the conformation of the44
with the aid of44
which is associated with44
the composition of the44
may be related to44
which is involved in44
purpose of this study44
as well as other44
be associated with the44
of the lipid bilayer44
to bind to the44
for the regulation of44
and can be used44
in line with the44
to the discovery of44
the possibility that the44
due to the presence44
is the case for44
and the use of44
a high level of44
from the plasma membrane44
been shown to play44
is also involved in44
at the beginning of44
the performance of the44
of proteins in the44
were found in the44
incubated for min at44
to the golgi apparatus44
the properties of the44
the binding site of43
of coronavirus spike proteins43
the production of the43
are shown in table43
protein was found to43
authors declare that they43
of the protein and43
might be involved in43
are located in the43
of our study was43
em structure of the43
of proteins involved in43
in an attempt to43
remains to be determined43
of the viral proteins43
the interaction with the43
in the last years43
play a pivotal role43
of a series of43
declare no conflict of43
to those of the43
aim of this work43
of the expression of43
spike protein of sars43
the potential role of43
of one of the43
cells as well as43
the goal of this43
the identification of a43
in an in vitro43
the herpes simplex virus43
from the cell surface43
understanding of the molecular43
the amino acid residues43
of the protein in43
aimed to investigate the43
of the interaction between43
were observed in the43
the beginning of the43
a potent inhibitor of43
of amino acids in42
conformational changes in the42
g for min at42
this is the case42
have been reported in42
coronavirus associated with severe42
for a long time42
is characterized by a42
one of the first42
there was no significant42
the presence and absence42
binding site of the42
respiratory syndrome coronavirus nucleocapsid42
of the hepatitis c42
a part of the42
study was to determine42
fluorescence resonance energy transfer42
an overview of the42
in the spinal cord42
these data indicate that42
have a role in42
entry into host cells42
the er to the42
cells were incubated with42
is not essential for42
in the level of42
and is involved in42
used to predict the42
at different stages of42
hepatitis c virus p42
functional analysis of the42
that most of the42
leads to the formation41
of peptides and proteins41
an integral membrane protein41
respiratory syndrome coronavirus envelope41
and the effect of41
the complexity of the41
to the endoplasmic reticulum41
the endoplasmic reticulum and41
of a large number41
known to be involved41
syndrome coronavirus envelope protein41
a single amino acid41
in order to understand41
have been used for41
of the virus to41
the inhibition of the41
the molecular biology of41
is located in the41
authors declare no conflict41
the interactions between the41
which is responsible for41
central role in the41
in hepatitis c virus41
the middle of the41
syndrome coronavirus nucleocapsid protein41
secondary structure of the41
the genome of the41
more than of the41
of the effect of41
is possible that the41
in the assembly of40
crystal structure of a40
proteins as well as40
foot and mouth disease40
were detected in the40
has been demonstrated to40
the absence of a40
the world health organization40
the most widely used40
the receptor binding domain40
our results demonstrate that40
a change in the40
in the presence and40
a final concentration of40
there is evidence that40
this work was to40
we conclude that the40
order to determine the40
syndrome coronavirus spike protein40
is a functional receptor40
in the secretory pathway40
is in agreement with40
we have demonstrated that40
a consequence of the40
will be discussed in40
to determine whether the40
study was to evaluate40
department of chemical engineering40
is the result of40
national institutes of health40
this is due to40
the mechanism of the40
by a number of40
in the er and40
has been suggested to39
it is suggested that39
the rough endoplasmic reticulum39
interesting to note that39
in the s protein39
to play an important39
the production of a39
d structure of the39
the evolution of the39
functional characterization of the39
it is believed that39
at least in part39
did not affect the39
the molecular mechanisms underlying39
are shown in figure39
s protein of sars39
to interfere with the39
an increasing number of39
in view of the39
compared to that of39
of the human genome39
plays a major role39
be used in the39
for a number of39
as a model system39
used to identify the39
the characterization of the39
important to note that39
on the structure of39
as described in the39
hepatitis b surface antigen39
novel coronavirus associated with39
to a lesser extent39
functional receptor for the39
to be used as39
in the majority of39
of cd and cd39
a novel coronavirus associated39
the location of the39
molecular dynamics simulations of39
no effect on the39
the binding affinity of39
could be involved in39
one of the two39
have been found in38
are essential for the38
to contribute to the38
may be important for38
in comparison with the38
is used as a38
patients with severe acute38
as well as its38
sequence analysis of the38
of the human proteome38
due to the high38
congo hemorrhagic fever virus38
of the presence of38
was identified as a38
as a part of38
major role in the38
taking into account the38
as a basis for38
which can be used38
and antigenicity of the38
in addition to its38
complete nucleotide sequence of38
of porcine circovirus type38
have been used in38
our data show that38
of this work is38
the genome sequence of38
are one of the38
for the diagnosis of38
the structural proteins of38
the immune response to38
we aimed to investigate38
to be present in38
has been observed in38
the concentration of the37
in the same way37
to the synthesis of37
the detection of the37
from the nucleus to37
by grants from the37
for a variety of37
in the induction of37
but not in the37
of the vaccine construct37
be important for the37
be taken into account37
have been identified by37
protein structure and function37
is interesting to note37
to the active site37
there was a significant37
is important to note37
with a variety of37
be explained by the37
by the observation that37
it was suggested that37
role of autophagy in37
a mouse model of37
in close proximity to37
the distribution of the37
in a way that37
with the host cell37
has been widely used37
food and drug administration37
have been proposed to37
of the novel coronavirus37
vascular smooth muscle cells37
order to investigate the37
a flow rate of37
did not show any37
by binding to the37
appears to be a37
in combination with the37
the structural and functional37
was added to each37
by a combination of37
despite the fact that37
to the host cell37
and the expression of37
was supported by grants37
in the levels of36
which is known to36
the role of this36
expressed in escherichia coli36
is the use of36
the integrity of the36
the localization of the36
at the nonpermissive temperature36
shown to play a36
of the th century36
human umbilical vein endothelial36
the application of the36
as well as an36
is mediated by a36
be found in the36
this suggests that the36
of the virus in36
as a target for36
the generation of a36
have been described in36
a role for the36
studies have demonstrated that36
play a central role36
for the recognition of36
the form of a36
for the determination of36
it is worth noting36
able to interact with36
the efficiency of the36
a significant decrease in36
are based on the36
of mhc class i36
the involvement of the36
the organization of the36
in the prefusion conformation36
the nucleus to the36
the dynamics of the36
innate and adaptive immunity36
over a period of36
and the formation of36
and western blot analysis36
that is required for36
by means of the36
of the viral rna36
acid sequence of the36
our study was to36
comparable to that of36
in addition to their36
of class i mhc36
the molecular weight of36
is crucial for the36
it has been found36
the virus life cycle36
proteins that interact with36
been shown to inhibit36
in the replication of36
of the binding site36
are thought to be36
in the control group36
in a range of36
to further investigate the36
with an increase in35
and one of the35
the m protein is35
the mechanisms involved in35
protein has been shown35
can be explained by35
was based on the35
of a protein is35
mode of action of35
of the b protein35
of the transcription factor35
in the milk of35
in relation to the35
protein encoded by the35
of some of the35
the amino acid composition35
s and s subunits35
m and e proteins35
been proposed to be35
was shown that the35
for the activation of35
has been reported in35
in the lumen of35
of the nervous system35
as is the case35
there is no evidence35
to be due to35
purification and characterization of35
complete genome sequence of35
the n protein is35
can be achieved by35
considered to be a35
histocompatibility complex class i35
of the identified proteins35
with the aim to35
members of the family35
on the level of35
of the fusion peptide35
by the formation of35
that the use of35
of each of the35
we are able to35
as shown in table35
to determine the effect35
in patients with severe35
the middle east respiratory35
a novel coronavirus from35
that are essential for35
was found in the35
based on the use35
to the study of35
a new generation of35
a number of different35
the viral spike protein35
as well as of35
supported by grants from35
the absence of any35
the release of the35
at the protein level35
the extent to which35
the control of a34
of the nucleocapsid protein34
in the human genome34
led to the identification34
the affinity of the34
were added to the34
in the immune system34
of the number of34
are shown in fig34
shown in figure a34
it was proposed that34
in the light of34
specific cd t cells34
h n influenza virus34
similar results were obtained34
by means of a34
play a significant role34
in order to evaluate34
of the influenza a34
to be related to34
in the nucleus of34
in spite of the34
hepatitis c virus replication34
has led to the34
that are associated with34
the development of an34
is determined by the34
we also found that34
has been used in34
aim of the study34
amino acid composition and34
the early stage of34
protein is required for34
understand the role of34
the mode of action34
to the site of34
the membrane of the34
the lack of a34
this is consistent with34
in order to be34
structure and dynamics of34
have also been used34
to the control group34
in an effort to34
has emerged as a34
class i mhc molecules34
in the structure of34
which is consistent with34
regulation of gene expression34
the center of the34
also be used to34
is the most abundant34
which is required for34
has also been used34
of the effects of34
important roles in the34
is similar to the34
the structure of a33
studies showed that the33
and activation of the33
to the best of33
was reported to be33
a and orf b33
may be used to33
were able to identify33
a novel class of33
is worth noting that33
the proteins in the33
best of our knowledge33
may be responsible for33
is expected to be33
one of the key33
d graphical representation of33
with that of the33
we have used a33
subcellular localization of the33
was carried out in33
in the serum of33
a number of studies33
role in the development33
the amino terminus of33
in addition to these33
were used as a33
the s ribosomal subunit33
the extracellular domain of33
of type i ifn33
a powerful tool for33
are predicted to be33
the functions of the33
of the viral envelope33
in the middle of33
a function of the33
is caused by a33
of the study was33
determine the effect of33
was to evaluate the33
of the active site33
the members of the33
it is also possible33
the interior of the33
with the formation of33
the functional role of33
could be due to33
in balb c mice33
closely related to the33
the s and s33
seems to be a33
of the murine coronavirus33
a comparison of the33
transported to the cell33
here we present a33
found to be the33
the tertiary structure of33
were isolated from the33
is to investigate the33
a web server for33
class i and class33
our aim is to33
be attributed to the33
vp vp vp vp33
of host protein synthesis33
sialic acid glycan binding33
we showed that the33
one of the best33
on the analysis of33
is a multifunctional protein33
a hidden markov model32
in the protein data32
the difference in the32
were used in the32
the past few years32
for the use of32
the relationship between the32
in the golgi complex32
proteins have been identified32
there is a need32
of different types of32
for the maintenance of32
has been found that32
in vero e cells32
were incubated for h32
the sars coronavirus nucleocapsid32
proteomic analysis of the32
are a family of32
proteins have been shown32
the open reading frame32
significant increase in the32
cells were cultured in32
was performed using a32
associated with a new32
to the pathogenesis of32
to the accumulation of32
was not affected by32
of the protein to32
the crystal structures of32
the recombinant s protein32
goal of this study32
lower than that of32
and the ability to32
of the structural proteins32
have been able to32
was used to identify32
the possible role of32
in the progression of32
cholera toxin b subunit32
the type i interferon32
in the degradation of32
and incubated for h32
found to be associated32
the best of our32
the milk of transgenic32
and its interaction with32
has proven to be32
could be detected in32
pp a and pp32
in order to develop32
open reading frame of32
been identified as a32
of these proteins in32
in the release of32
sars coronavirus e protein32
may be associated with32
is based on a32
human respiratory disease in32
even in the absence32
in the bone marrow32
required for viral replication32
forms a complex with32
confocal laser scanning microscopy32
of the human immunodeficiency32
on the host cell32
leading to the formation32
method was used to32
have been used as31
have been detected in31
the case for the31
is regulated by the31
does not appear to31
is highly expressed in31
a new coronavirus associated31
and their role in31
is characterized by the31
it is not known31
a wide spectrum of31
terminal half of the31
cysteine mutant f proteins31
new coronavirus associated with31
molecular weight of the31
has been used for31
are found in the31
has been detected in31
genome sequence of the31
a new coronavirus of31
pneumonia outbreak associated with31
also been used to31
used as a model31
entry into the host31
and transmission electron microscopy31
is necessary for the31
a common feature of31
analysis revealed that the31
is a component of31
the result of the31
to the inhibition of31
in order to improve31
western blot analysis of31
and the production of31
been suggested to be31
new coronavirus of probable31
of the mechanism of31
the spike protein is31
a potential target for31
is an urgent need31
our findings suggest that31
nucleocapsid protein of sars31
is known that the31
on the nature of31
a pneumonia outbreak associated31
analysis of the human31
through the secretory pathway31
compared to those of31
of genes involved in31
dimensional structure of the31
the m protein of31
the side chain of31
was carried out with31
the treatment of covid31
and expression of the31
the coronavirus mouse hepatitis31
the functional significance of31
to study the effect31
of the spike glycoprotein31
is located at the31
experiments were carried out31
outbreak associated with a31
have demonstrated that the31
in order to find31
by a variety of31
of amino acids and31
were washed with pbs31
does not seem to31
sera from sars patients31
the mhc class i31
the evaluation of the31
laser desorption ionization time31
the heat shock protein31
it was possible to31
the nucleotide sequence of31
with a new coronavirus31
ncov spike in the30
for the binding of30
and evolution of the30
been shown to bind30
that the number of30
are summarized in table30
the first aug codon30
been identified in the30
essential role in the30
infectious bronchitis virus e30
evolution of coronavirus spike30
were tested for their30
umbilical vein endothelial cells30
of the recombinant protein30
is not fully understood30
the objective of this30
found to be a30
was performed as described30
balb c mice were30
one or more of30
with human respiratory disease30
the pi k akt30
here we report the30
investigate the effects of30
it will be interesting30
the nucleus and the30
they are involved in30
hepatitis c virus rna30
to our understanding of30
we demonstrate that the30
were obtained from the30
the results indicated that30
the vesicular stomatitis virus30
of probable bat origin30
expression levels of the30
we propose that the30
for most of the30
part of the protein30
associated with human respiratory30
and the regulation of30
of the s subunit30
we are interested in30
spike in the prefusion30
between the nucleus and30
will be interesting to30
used for the treatment30
was detected in the30
samples were collected from30
supported in part by30
coronavirus associated with human30
with a number of30
recent studies have shown30
as a first step30
the c terminus of30
with the presence of30
of the host immune30
an inhibitor of the30
is closely related to30
the increase in the30
to act as a30
to the number of30
of the most abundant30
cell surface expression of30
has been found in30
on the type of30
was determined by the30
chronic obstructive pulmonary disease30
the intensity of the30
been suggested that the30
the role played by30
results of this study30
order to study the30
at a flow rate30
side of the membrane30
respiratory syndrome coronavirus infection30
studies are needed to30
expression and purification of30
respiratory disease in china30
of the hepatitis b30
the elucidation of the30
has been applied to30
with the development of30
coronavirus of probable bat30
of intrinsically disordered proteins30
are associated with the30
of the molecular mechanisms30
added to each well29
of the viral life29
cd t cells in29
on the activity of29
used to investigate the29
to be in the29
of action of the29
the spike protein and29
are a number of29
the potential to be29
in the inhibition of29
there are a number29
protein is involved in29
the spike glycoprotein of29
the origin of the29
an understanding of the29
the product of the29
and evolution of coronavirus29
the result of a29
it is unclear whether29
with the m protein29
on the effect of29
of molecular biology and29
a and pp ab29
interact with each other29
it was concluded that29
could serve as a29
the physiological role of29
as well as on29
of proteins that are29
antigenicity of the sars29
of the ns protein29
nucleocapsid protein of severe29
rift valley fever virus29
in the genome of29
high performance liquid chromatography29
investigated the effects of29
there is an urgent29
we focused on the29
be detected in the29
the gene of interest29
amino acid composition of29
absence and presence of29
binding sites in the29
the coronavirus spike protein29
the last few years29
were significantly higher in29
which are known to29
of the gene encoding29
of the use of29
the golgi apparatus and29
a molecular mass of29
cell leukemia virus type29
absence or presence of29
as a negative control29
structure of the n29
the sequences of the29
the primary structure of29
was associated with a29
early stages of the29
acids in cell culture29
have been made to29
amino acids in cell29
analysis of the sars29
without the need for29
that is involved in29
of the proteins in29
the context of a29
at an early stage29
glial fibrillary acidic protein29
study the role of29
hepatitis virus strain a29
the thickness of the29
i and class ii29
the important role of29
be used as an29
for the construction of29
a large variety of29
for the inhibition of29
increase in the number29
a significant reduction in29
entry of the virus29
as a model for29
of the golgi complex29
in the early stages29
a new method for28
used to analyze the28
the purpose of the28
are important for the28
of the formation of28
methods have been developed28
human parainfluenza virus type28
analysis showed that the28
not included in the28
to be crucial for28
of the unfolded protein28
might be due to28
the addition of the28
in order to avoid28
in most of the28
of a set of28
it is essential to28
of the transmembrane domain28
vg vd t cells28
involved in the pathogenesis28
we could show that28
were carried out in28
tertiary structure of the28
in cells treated with28
proteins encoded by the28
used to assess the28
of the proteins were28
of the cytoplasmic domain28
are also involved in28
cells in response to28
has been linked to28
a mutation in the28
and middle east respiratory28
and is blocked by28
viral and host proteins28
there is increasing evidence28
the development of vaccines28
for the majority of28
of the coronavirus mouse28
in a recent study28
in order to increase28
will be used to28
was used as an28
this work is to28
on the mechanism of28
were identified in the28
was found to have28
has not been reported28
that there is no28
into the lumen of28
which has been shown28
for the investigation of28
remains to be elucidated28
the expression of genes28
by an increase in28
receptor for the sars28
it is noteworthy that28
for the sars coronavirus28
of the protein was28
have been carried out28
with the addition of28
on the structure and28
the host cell membrane28
and a number of28
in the pathophysiology of28
a total of proteins28
to a variety of28
cloning and expression of28
turned out to be28
blood samples were collected28
compared to the wild28
the innate and adaptive28
the viral replication cycle28
identified in this study28
to changes in the28
in the absence and28
required for the formation28
of the wild type28
that are required for28
used to evaluate the28
plays an essential role28
in the maintenance of28
can lead to the28
the number of proteins28
known to be a28
state of the art28
study was designed to28
are part of the28
different regions of the28
in viral replication and28
for viral replication and28
a diverse set of28
by transmission electron microscopy28
some of the most28
acid sequences of the28
to test this hypothesis28
enzyme is a functional28
the addition of a28
structural characterization of the28
with regard to the28
the development of effective28
of these proteins are28
from patients with pneumonia28
a molecular weight of28
based on the analysis28
was supported by a28
that the n protein28
blocked by a clinically27
by a clinically proven27
solution structure of the27
an example of a27
the reader is referred27
in a similar manner27
of recombinant proteins in27
entry depends on ace27
patients and healthy controls27
on ace and tmprss27
influenza a virus m27
an in vitro model27
in the liver and27
the effect of different27
can be modulated by27
novel coronavirus from patients27
have been isolated from27
s d fusion protein27
in line with this27
has been identified in27
shown to be involved27
hepatitis c virus ns27
makes it possible to27
tmprss and is blocked27
during the process of27
of intrinsic disorder in27
in the absence or27
mouse hepatitis virus strain27
the strength of the27
in combination with a27
a clinically proven protease27
of some of these27
has recently been shown27
but also in the27
and adaptive immune responses27
and has been shown27
the core of the27
of porcine reproductive and27
the regulation of cell27
in the brain and27
a new family of27
depends on ace and27
sequence of the sars27
comparative analysis of the27
as can be seen27
also found to be27
the components of the27
in each of the27
is blocked by a27
ace and tmprss and27
and at the same27
was also found to27
fusion of the viral27
may be useful in27
changes in the expression27
studies are required to27
we set out to27
of programmed cell death27
the expression of cd27
by the lack of27
also involved in the27
as a negative regulator27
of the orf protein27
a model for the27
the role of autophagy27
be essential for the27
shown to bind to27
in the analysis of27
coronavirus from patients with27
used in the treatment27
have also been reported27
for the control of27
the investigation of the27
clinically proven protease inhibitor27
order to understand the27
class i fusion proteins27
study is to investigate27
cd t cells and27
it was reported that27
were incubated with the27
was inserted into the27
the shape of the27
and are involved in27
may lead to the27
and is associated with27
is the first report27
over the past years27
the study was to27
the nucleolus is a27
in this study the27
and tmprss and is27
or more of the27
and an increase in27
peptides derived from the27
breast cancer cell lines27
to be used for27
were carried out using27
it is assumed that27
dependent on the presence27
the first step of27
to a final concentration27
cell entry depends on27
on the plasma membrane27
that it is a27
different stages of the27
the porcine epidemic diarrhea27
involved in the control27
in breast cancer cells27
de novo design of27
these results show that27
the inhibitory activity of27
is encoded by the27
in response to a27
the action of the26
by interacting with the26
murine coronavirus spike protein26
the kinetics of the26
the entry of the26
the first step in26
amino acid residues of26
was no significant difference26
previous studies have shown26
and is responsible for26
it has recently been26
the presence of two26
to be one of26
is critical for the26
study the effects of26
under the same conditions26
protein was shown to26
in cd t cells26
and then incubated with26
bovine viral diarrhea virus26
committee on taxonomy of26
nucleus to the cytoplasm26
is not surprising that26
to a decrease in26
avian coronavirus infectious bronchitis26
it is not surprising26
a wide array of26
amino acid composition to26
ion channel activity of26
mouse mammary tumor virus26
the antigenicity of the26
the recognition of the26
in good agreement with26
influenza virus m protein26
for the delivery of26
to understand the mechanism26
in addition to this26
proteins were found to26
that is able to26
by the action of26
analysis was carried out26
the gene encoding the26
epidemic diarrhea virus in26
in the region of26
in order to achieve26
the surface of a26
reader is referred to26
not appear to be26
been demonstrated that the26
expression in escherichia coli26
to cd t cells26
been reported that the26
patients with pneumonia in26
with each other and26
respiratory syndrome coronavirus nsp26
the role of these26
in the life cycle26
during the development of26
the eif f complex26
has been demonstrated in26
to severe acute respiratory26
has been used as26
influenza a virus ns26
in the lipid bilayer26
the establishment of a26
we investigated the effect26
mechanisms involved in the26
was used to predict26
which leads to the26
the free energy of26
or in combination with26
the results of our26
can act as a26
high density multiepitope protein26
with pneumonia in china26
the m proton channel26
cells in the presence26
in the search for26
it is based on26
international committee on taxonomy26
is caused by the26
included in this study26
in contact with the26
method is based on26
and in some cases26
were significantly higher than26
that some of the26
be the result of26
to investigate the effects26
of the membrane protein26
has been described in26
it is not yet26
respiratory syndrome coronavirus a26
in the viral life26
on taxonomy of viruses26
and dynamics of the26
the difference between the26
of the viral protein26
can be attributed to26
on the cytoplasmic side26
and stability of the26
of transmissible gastroenteritis virus26
these observations suggest that26
have been linked to26
the time course of26
of differentially expressed proteins26
the significance of the26
is a powerful tool26
was also shown to26
acid composition to predict25
of the capsid protein25
play key roles in25
in this study were25
are expected to be25
has shown that the25
using a variety of25
of proteins from the25
as a means to25
development of a new25
involved in regulation of25
to the end of25
by size exclusion chromatography25
the n terminus of25
of the virus and25
has no effect on25
to the nucleus and25
be part of the25
this article can be25
known to interact with25
t cells in the25
were analyzed by sds25
of the cytoplasmic tail25
have no competing interests25
in our understanding of25
the hypothesis that the25
are presented in table25
with the ability to25
in the accumulation of25
of the viral replication25
converting enzyme is a25
compared to wild type25
local alignment search tool25
which is based on25
for the characterization of25
of the two proteins25
to the cytoplasm and25
to the immune system25
respiratory syndrome coronavirus replication25
have been described to25
has a role in25
cloning and characterization of25
is able to bind25
the value of the25
that are known to25
are involved in a25
of a range of25
as a receptor for25
this research was supported25
taking advantage of the25
but it is not25
for the discovery of25
the fusion of the25
at amplitude for min25
the endoplasmic reticulum to25
in order to further25
also referred to as25
conformational change in the25
as part of a25
a new approach to25
induce the formation of25
we are currently investigating25
can serve as a25
is a receptor for25
and molecular dynamics simulations25
been found in the25
is the fact that25
has been carried out25
in the present paper25
as a tool for25
reading of the manuscript25
the catalytic domain of25
the absence and presence25
of the protein of25
antigen processing and presentation25
to the release of25
of low molecular weight25
a major component of25
internal initiation of translation25
end of the genome25
with a focus on25
in the past few25
an important role of25
which is one of25
structural proteins of the25
further studies are required25
are not well understood25
these results indicated that25
supported by a grant25
essential for viral replication25
an important role for25
can be detected in25
has also been proposed25
was to determine the25
been the subject of25
to the understanding of25
which is characterized by25
were used to determine25
to the regulation of25
as an alternative to25
in the s subunit25
the vicinity of the25
we have been able25
been proposed that the25
in any of the25
as an inhibitor of25
compared with the control25
which acts as a25
are consistent with the25
and found that the25
the yield of the25
infectious bursal disease virus25
to their ability to25
cytoplasmic domain of the25
by flow cytometry and25
at the university of25
a major cause of25
is a type i25
cells were grown in25
to be important in25
with rna chaperone activity25
of the in vitro25
this study aimed to25
were included in the25
for the assessment of25
and their interactions with25
article can be found25
in complex with the25
active site of the25
that interact with the25
cytoplasmic tail of the25
work is supported by25
well as for the25
in the immune response25
is a prerequisite for25
internal ribosomal entry site25
that are responsible for25
nucleus and the cytoplasm25
at an moi of25
at room temperature in25
structural and functional characterization25
the discovery of a25
it is involved in25
of the fact that25
in the cytoplasmic tail25
are among the most24
sonication at amplitude for24
translation initiation factor eif24
is likely that the24
studied the effect of24
involved in the interaction24
of newcastle disease virus24
the pathogenesis of the24
protein interaction map reveals24
the role of a24
been developed for the24
basis for the recognition24
de haan et al24
be useful in the24
are members of the24
is a potent inhibitor24
may act as a24
for the isolation of24
we have analyzed the24
plasma membrane of the24
to a number of24
in the diagnosis of24
are characterized by the24
our data demonstrate that24
no significant difference in24
the removal of the24
the disruption of the24
is a common feature24
they have no competing24
a portion of the24
the degradation of the24
and analysis of the24
through the activation of24
within the context of24
of science and technology24
the differences between the24
the enzymatic activity of24
can be seen in24
national center for biotechnology24
results indicated that the24
here we present the24
this study we have24
the catalytic activity of24
in such a way24
was identified as the24
the immune system and24
an e ubiquitin ligase24
the most abundant protein24
our data indicate that24
terminal end of the24
sequences have been identified24
is expressed in the24
as a marker of24
it is shown that24
this work is supported24
biological activity of the24
we have identified a24
to one of the24
the orientation of the24
the rational design of24
endoplasmic reticulum to the24
also play a role24
heterogeneous nuclear ribonucleoprotein a24
for binding to the24
alone or in combination24
before and after the24
is yet to be24
we focus on the24
in the last decade24
might play a role24
the selection of the24
a large proportion of24
and to a lesser24
tables s and s24
be used to study24
of epidermal growth factor24
supported by the national24
induction of apoptosis in24
were performed using the24
the cells were washed24
cells infected with the24
been used for the24
regulates the expression of24
the discovery of novel24
cells were fixed with24
the protein composition of24
the purity of the24
in the cytoplasmic domain24
appears to be the24
on the number of24
the time of writing24
which is essential for24
found to be highly24
data indicate that the24
supported by the russian24
molecular biology of coronaviruses24
the epidermal growth factor24
in the sera of24
is an integral membrane24
molecular mass of kda24
tumor necrosis factor alpha24
was approved by the24
the class i mhc24
is transported to the24
a number of proteins24
immunization of mice with24
significant difference between the24
basic local alignment search24
of the p protein24
structure and mechanism of24
to be mediated by24
in the evolution of24
which is present in24
have been demonstrated to24
a number of other24
are located within the24
are the most common24
the induction of the24
been shown to induce24
are similar to those24
were selected for further24
cells transfected with the24
of patients infected with24
it is expected that24
of one or more24
of the activity of24
and mouth disease virus24
the cell surface of24
have been observed in24
the appearance of a24
chinese hamster ovary cells24
reported in the literature24
have also been shown24
the observation that the24
the structures of the24
is released from the24
acid residues in the24
was supported by grant24
objective of this study24
a large amount of24
referred to as the24
the present work we24
representation of protein sequences24
and their ability to24
proteins targeted by sars23
to the generation of23
it can be concluded23
that is essential for23
the key role of23
room temperature for min23
domain of the spike23
that the formation of23
from the analysis of23
breast cancer cell line23
and the absence of23
by mutations in the23
at the interface of23
not seem to be23
into the role of23
a significant increase of23
for a period of23
envelope protein ion channel23
that binds to the23
would be expected to23
were expressed in e23
peptides corresponding to the23
purification of recombinant proteins23
is composed of a23
spike protein is a23
coronavirus envelope protein ion23
of the interactions between23
about the role of23
as shown by the23
is not yet known23
the fact that it23
it is conceivable that23
of the function of23
in the modulation of23
protein of the sars23
as well as some23
with respect to their23
the creative commons attribution23
of scov e protein23
for hepatitis c virus23
crystal structures of the23
that the protein is23
for recombinant protein production23
amino acid residues and23
in the human body23
to the cell membrane23
when compared with the23
there has been a23
we have recently shown23
in a murine model23
the immunogenicity of the23
in the use of23
from the cytoplasm to23
design and synthesis of23
to the wild type23
that could be used23
proteins such as the23
this indicates that the23
of murine hepatitis virus23
the activity of a23
structure of the human23
the identification of novel23
we demonstrated that the23
may be used as23
in the biosynthesis of23
to study the role23
transmembrane domain of the23
natural science foundation of23
was determined using the23
the protective effect of23
physicochemical properties of the23
is due to a23
the endoplasmic reticulum membrane23
terminal amino acids of23
conformational changes of the23
the intracellular localization of23
pivotal role in the23
of the creative commons23
has yet to be23
simplex virus type infection23
graphical representation of protein23
the results of these23
the design of new23
of african swine fever23
of the sars virus23
each of the three23
contribute to the development23
of the sars cov23
mrna and protein expression23
in contrast to other23
to gain insight into23
the green fluorescent protein23
to be dependent on23
tumor necrosis factor receptor23
type i and type23
in vascular smooth muscle23
the design of a23
rats were divided into23
one of the important23
by western blot and23
a variety of cellular23
with fetal bovine serum23
of the actin cytoskeleton23
in the loss of23
it has not been23
and the lack of23
the start of the23
of protein synthesis in23
authors would like to23
in the early s23
the therapeutic potential of23
binding site in the23
will focus on the23
of this class of23
with a view to23
in the past years23
the distance between the23
requires the presence of23
a vital role in23
has been attributed to23
the early phase of23
the presence of high23
an urgent need to23
is not sufficient to23
found to interact with23
it seems likely that23
bronchitis virus e protein23
the absence or presence23
from the severe acute23
proteins with rna chaperone23
target for the development23
these data demonstrate that23
to understand the role23
as a marker for23
we observed that the23
as a starting point23
of the g protein23
authors declare no competing23
mrna and protein levels23
in order to test23
by the immune system22
classical swine fever virus22
as a template for22
for the interaction with22
a key regulator of22
is also able to22
of heat shock protein22
compared with that of22
type i ifn signaling22
understand the mechanism of22
different from that of22
from the er membrane22
been used as a22
amino acid sequence identity22
rna was extracted from22
the cleavage of the22
by the induction of22
that the binding of22
the morphology of the22
porcine transmissible gastroenteritis virus22
the differences in the22
of the infected cells22
the way in which22
the accuracy of the22
the first time the22
the identity of the22
experiments were performed in22
of gene expression in22
are more likely to22
the golgi complex and22
in the culture medium22
could be used in22
of the proteins identified22
the first and second22
of the gastrointestinal tract22
that the amount of22
the importance of this22
have been suggested to22
the er and golgi22
the impact of the22
and the activation of22
and structural characterization of22
evs were isolated by22
been used in the22
on the production of22
been used to study22
has the ability to22
or s t protein22
able to bind to22
is targeted to the22
blood samples were taken22
the coronavirus nucleocapsid protein22
to the role of22
there were no significant22
that one of the22
it is tempting to22
proteins that are involved22
van der waals interactions22
it can be used22
which are responsible for22
of human papillomavirus type22
several lines of evidence22
in the venom of22
for the purification of22
article distributed under the22
the cells were then22
the murine coronavirus spike22
class i and ii22
results are consistent with22
by the expression of22
the dna damage response22
was similar to that22
the hydrophobic thickness of22
of the same protein22
been identified by blast22
described in the literature22
is considered as a22
the e protein of22
analysis of the protein22
it has been postulated22
nucleocapsid protein of the22
on the n protein22
studies have suggested that22
is limited by the22
of the porcine epidemic22
viral rna synthesis and22
it is thought that22
the replication of the22
the host cell surface22
involved in this process22
vesicular stomatitis virus g22
are found to be22
the contents of the22
the cytoplasmic tails of22
significant role in the22
has been supported by22
identified by mass spectrometry22
the physicochemical properties of22
to that observed in22
of each amino acid22
are a group of22
to localize to the22
was supported in part22
is derived from the22
that has been shown22
the aim is to22
the national center for22
in a wide variety22
the proteins of the22
may play an important22
could not be detected22
protein sequences based on22
was calculated using the22
access article distributed under22
an essential component of22
to a family of22
statistical analysis was performed22
have focused on the22
distributed under the terms22
resulting in the formation22
as the number of22
used to measure the22
and size exclusion chromatography22
in polarized epithelial cells22
and the effects of22
order to evaluate the22
of human serum albumin22
were washed twice with22
the correlation between the22
the function of these22
the early secretory pathway22
in a rat model22
the case of a22
to determine if the22
were used to identify22
to study the effects22
is in contrast to22
in the processing of22
endoplasmic reticulum stress and22
with the control group22
and in the presence22
from a patient with22
to address this issue22
were also able to22
was also observed in22
through the nuclear pore22
as a therapeutic target22
the presence of both22
between the er and22
the design of novel22
the international committee on22
mutational analysis of the22
probably due to the22
wild type and mutant22
of the viral and22
was carried out to22
according to our results22
is proportional to the22
the er and the22
was determined to be22
hepatitis b virus x22