This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.
| identifier | question |
|---|---|
| cord-000182-ni6iyzdn | CYP1A1: friend or foe? |
| cord-003020-q69f57el | Why OppA protein can bind sequence- independent peptides? |
| cord-001567-3bw7jbzq | Mitochondrial creatine kinase as a tumor- associated marker Elevated creatine kinase activity in primary hepatocellular carcinoma Different behavior of agmatine in liver mitochondria: inducer of oxidative stress or scavenger of reactive oxygen species? |
| cord-003817-k3m72uxw | cellular attachment and infection Immature dengue virus: a veiled pathogen? |
| cord-013315-plptulfb | Mycobacterium avium subspecies paratuberculosis cause Crohn's disease, ulcerative colitis · · · and colorectal cancer? |
| cord-002100-dt5zvebj | why soybean seeds?" |
| cord-001898-ntqyjqqk | D18 G transthyretin is monomeric, aggregation prone, and not detectable in plasma and cerebrospinal fluid: a prescription for central nervous system amyloidosis? |
| cord-000642-mkwpuav6 | Perkinsus marinus Evidence indicating the existence of a novel family of serine protease inhibitors that may be involved in marine invertebrate immunity Serine protease inhibitor cvSI-1 potential role in the eastern oyster host defense against the protozoan parasite Perkinsus marinus Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? |
| cord-000479-u87eaaj8 | The contributions of protein bisulfide isomerase and its homologues to oxidative protein folding in the yeast endoplasmic reticulum Protein disulfide isomerase Recycling of peroxiredoxin IV provides a novel pathway for disulphide formation in the endoplasmic reticulum Oxidative protein folding by an endoplasmic reticulum- localized peroxiredoxin Oxidative folding in the endoplasmic reticulum: towards a multiple oxidant hypothesis? |
| cord-000674-36jzzy77 | How does impairment of autophagy lead to diseases? |
| cord-004181-exbs3tz7 | The Journal of Infectious Diseases Development of Streptococcus agalactiae vaccines for tilapia Streptococcal β protein has separate binding sites for human factor h and IgA- Fc Identification of group B streptococcal Sip protein, which elicits cross- protective immunity Immunotherapy of established( pre)malignant disease by synthetic long peptide vaccines A web resource for designing subunit vaccine against major pathogenic species of bacteria Prospects for control of emergimg infectious dyseases with plasmid DNA vaccines DNA vaccines: ready for prime time? |
| cord-012878-j9vndxgg | Purified NbrSBA was found to c Accumulation of rSBA at day 5 with different A 600 concentrations of Agrobacterium.? |
| cord-016126-i7z0tdrk | v.2-a server for in silico prediction of allergens VaxiJen: a server for prediction of protective antigens, tumour antigens and subunit vaccines High performance signal peptide prediction based on sequence alignment techniques Meningococcus B: control of two outbreaks by vaccination Protein identification and analysis tools on the ExPASy server Unipro UGENE NGS pipelines and components for variant calling, RNA- seq and ChIP- seq data analyses Discovering a vaccine against neosporosis using computers: is it feasible? |
| cord-007755-o2r8ktie | Can we infer peptide recognition specifi city mediated by SH3 domains? |
| cord-017968-17d37a2z | RNA- binding protein Immunoprecipitation from whole- cell extracts Regulation of pri- miRNA processing by the hnRNPlike protein AtGRP7 in Arabidopsis RNA- binding proteins revisited: the emerging Arabidopsis mRNA interactome Whirly proteins as communicators between plant organelles and the nucleus? |
| cord-009614-lbjesv8y | How does HIV cause AIDS? |
| cord-000708-iuo2cw23 | These results indicate that, first of all, it is common for herpesviruses to incorporate cellular proteins into their viral particles and, secondly, that www.frontiersin.org? |
| cord-000708-iuo2cw23 | has multiple functions in gene regulation and cell cycle control and is a prime target for viral manipulation Viruses and the human DEAD- box helicase DDX3: inhibition or exploitation? |
| cord-021626-ck2kybtp | How reliable are commercial allergy tests? |
| cord-003761-ikni2acz | A viral strategy to survive? |
| cord-003761-ikni2acz | The convergence of multiple signalling pathways on ROS production? |
| cord-018018-2yyv8vuy | In planta protein sialylation through overexpression of the respective mammalian pathway Transient Expression of Mammalian Genes in N. benthamiana to Modulate N- Glycosylation Immunogenicity of a subunit vaccine against Bacillus anthracis A plant- produced protective antigen vaccine confers protection in rabbits against a lethal aerosolized challenge with Bacillus anthracis Ames spores How did international agencies perceive the avian influenza problem? |
| cord-014597-66vd2mdu | : Comparability study from Process Performance to Product Quality Attributes Maximizing binding capacity for protein A chromatography Protein Glycosylation and its Role in Protein Folding Afucosylated antibodies increase activation of FcγRIIIa- dependent signaling components to intensify processes promoting ADCC Sialic Acids and other Nonulosonic Acids Production of antibody in insect cells Suitability and perspectives on using recombinant insect cells for the production of virus- like particles Cloning of cDNA and characterization of anti- RNase A monoclonal antibody 3A21 Production of functional antibody Fab fragment by recombinant insect cells Optimization of HEK-293S cell cultures for the production of adenoviral vectors in bioreactors using on- line OUR measurements Enhancing heterologous protein expression and secretion in HEK293 cells by means of combination of CMV promoter and IFNα2 signal peptide HEK293 cell culture media study towards bioprocess optimization: animal derived component free and animal derived component containing platforms Comparison of control strategies for fed- batch culture of hybridoma cells based on on- line monitoring of oxygen uptake rate, optical cell density and glucose concentration Continuous bioprocessing: The real thing this time? |
| cord-014597-66vd2mdu | Eliminating canine rabies, the principal source of human infection: What will it take? |
| cord-016652-x8t3lf1x | I rex- encoded protein is essential for cytoplasmic accumulation of unspliced viral mRNA Identification of nucleophosmin/ B23, an acidic nucleolar protein, as a stimulatory factor for in vitro replication of adenovirus DNA complexed with viral basic core proteins Induction of apoptosis by viruses: what role does the nucleolus play? |
| cord-016652-x8t3lf1x | the nucleolus-a gateway to viral infection? |
| cord-000003-ejv2xln0 | Is uncontrolled diabetes mellitus associated with defective collectin function? |
| cord-000003-ejv2xln0 | Nitrated SP- A does not enhance adherence of Pneumocystis carinii to alveolar macrophages Increased suscepti-• bility of diabetic mice to influenza virus infection: compromise of collectin- mediated host defence of the lung by glucose? |
| cord-013178-li1x1m25 | ( PCV2) infection be eradicated by mass vaccination? |
| cord-013178-li1x1m25 | : Is eradication a possibility? |
| cord-021500-sy6lnt7b | I. Changes in the activities of 2',3'-cyclic nucleotide 3'-phosphohydrolase, oligodendroglial ceramide galactosyl transferase, and the hydrolysis of the alkenyl group of alkenyl, acyl- glycerophospholipids by plasmalogenase in different regions of the brain Mitogenic effect of axolemmaenriched fraction on cultured oligodendrocytes Shiverer, an autosomal recessive mutant mouse with myelin- deficiency Synthesis and incorporation of myelin polypeptide into CNS myelin In vivo and in vitro observations on laminin production by Schwann cells N- terminal sequence homology among retinoid- binding proteins from bovine retina Glial fibrillary acidic( GFA) protein in Schwann cells: fact or artifact? |
| cord-000372-wzwpyvll | Nevertheless, what might the biological relevance of these events be for a cytoplasmic virus? |
| cord-000372-wzwpyvll | another mechanism for host protein synthesis shutoff? |
| cord-017400-jxbhdch8 | The nucleolus-a gateway to viral infection? |
| cord-017400-jxbhdch8 | What is the best MS quantification technique to use? |
| cord-011602-hzqayt3n | How Robust Are Protein Folding Simulations with Respect to Force Field Parameterization? |
| cord-011602-hzqayt3n | Introducing the D-2 concept Targeting Intrinsically Disordered Transcription Factors: Changing the Paradigm Intrinsically Disordered Side of the Zika Virus Proteome Untapped Potential of Disordered Proteins in Current Druggable Human Proteome Intrinsic disorder associated with 14- 3- 3 proteins and their partners Intrinsic disorder here, there, and everywhere, and nowhere to escape from it Disease mutations in disordered regions- exception to the rule? |
| cord-104279-choywmwd | The rate of bulk flow from the Golgi to the plasma membrane Protein degradation in the endoplasmic reticulum Membrane protein sorting: biosynthesis, transport, and processing of yeast vacuolar alkaline phosphatase A new class of lysosomal/ vacuolar protein sorting signals Protein glycosylation in yeast Rapid and efficient sitespecific mutagenesis without phenotypic selection Structure of a yeast pheromone gene( MFa): a putative a- factor precursor contains four tandem copies of mature c~-factor Mutations in the cytoplasmic domain of the 275 kd mannose 6-phosphate receptor differentially alter lysosomal enzyme sorting and endoeytosis Golgi retention signals: do membranes hold the key? |
| cord-000884-zq8kqf6h | But is there a model membrane system that is the best for membrane- protein reconstitution? |
| cord-000884-zq8kqf6h | Why use half a membrane to characterize protein- membrane interactions? |
| cord-010681-tmpxs9og | -added work or added value? |
| cord-010681-tmpxs9og | Immunodrugs: therapeutic VLPbased vaccines for chronic diseases Immunogenicity of takedas bivalent viruslike particle( VLP) norovirus vaccine( NoV) candidate in children from 6 months up to 4 years of age Cell- free protein synthesis of norovirus virus- like particles Rapid production and characterization of antimicrobial colicins using Escherichia coli- based cell- free protein synthesis Application of antimicrobial peptides of the innate immune system in combination with conventional antibiotics- a novel way to combat antibiotic resistance? |
| cord-022499-7d58f1k3 | The structure of the potassium channel: Molecular basis of K+ conduction and selectivity Molecular sorting of lipids by bacteriorhodopsin in dilauroylphophatidylcholine/ distearoylphosphatidylcholine lipid bilayers Is the protein/ lipid hydrophobic matching principle relevant to membrane organization and functions? |
| cord-017866-h5ttoo0z | Multiple trimeric G- proteins on the trans- Golgi network exert stimulatory and inhibitory effects on secretory vesicle formation T rimeric G- proteins of the trans- Golgi network are involved in the formation of constitutive secretory vesicles and immature secretory granules Formation of nascent secretory vesicles from the trans- Golgi network of endocrine cells is inhibited by tytosine kinase and phosphatase inhibitors Cooperativity of phosphatidylinositol transfer protein and phospholipase D in secretory vesicle formation from the TGN- phosphoinositides as a common denominator? |
| cord-017866-h5ttoo0z | Secondly, how are granule cargo proteins sorted to the same destination as other proteins that are essential for DCG function, such as membrane fusion machinery? |
| cord-196265-mvnkkcow | Conformationally active integrin endocytosis and traffic: why, where, when and how? |
| cord-022354-aqtceqqo | Thus even in this well- defined situation, where an amino acid sequence is known to play a functional role in the sorting process, it can be impossible to predict with confidence its location in the protein; how then might we expect to identify additional sorting sequences that may or may not exist within the structural domain of a transported protein? |
| cord-022354-aqtceqqo | What then is the function of the cytoplasmic domain of the env glycoprotein? |
| cord-048471-7jszm1nd | The genomelinked protein VPg of the Norwalk virus binds eIF3, suggesting its role in translation initiation complex recruitment VPg of murine norovirus binds translation initiation factors in infected cells New Ways of Initiating Translation in Eukaryotes? |
| cord-222664-4qyrtzhu | What Is the Evidence? |
| cord-024193-khdvj6t5 | However, the most interesting scientific question in biomarker discovery is as follows: can we find novel antigens and their corresponding antibodies without previous knowledge about the antigen? |
| cord-018969-0zrnfaad | Where have all the bees gone? cord-018969-0zrnfaad What Is Causing CCD? cord-252147-bvtchcbt Is declining innovation in the pharmaceutical industry a myth? cord-018437-yjvwa1ot The size and conformation of Kaposi's sarcoma- associated herpesvirus( human herpesvirus 8) DNA in infected cells and virions Characterization of a novel coronavirus associated with severe acute respiratory syndrome Nucleotide sequence of the Kaposi sarcoma- associated herpesvirus( HHV8) Human bocavirus: passenger or pathogen in acute respiratory tract infections? cord-018437-yjvwa1ot What does virus evolution tell us about virus origins? cord-017999-saxwqc2j How might this change in flexibility be effected? cord-017999-saxwqc2j To what extent are variations in DNA flexibility reflected in genomic organisation? cord-009792-e2vvi8qo How far can sequences diverge? cord-009792-e2vvi8qo How representative are the known structures of the proteins in a complete genome? cord-009792-e2vvi8qo Predicting structures for genome proteins From protein structure to function Genomic- scale comparison of sequence- and structure- based methods of function prediction: Does structure provide additional insight? cord-000264-o80duxhs How much of the proteome do we see with discovery- based proteomics methods and how much do we need to see? cord-000264-o80duxhs Is proteomics heading in the wrong direction? cord-000264-o80duxhs Our genome unveiled Highthroughput mass spectrometric discovery of protein posttranslational modifications Perspectives for mass spectrumetry and functional proteomics Proteomic technology for biomarker profiling in cancer: an update 2D protein electrophoresis: can it be perfected? cord-000012-p56v8wi1 Science Are there bugs in our genome? cord-000012-p56v8wi1 The genome of Melanoplus sanguinipes entomopoxvirus Cloning and expression of a gene encoding a Campoletis sonorensis polydnavirus structural protein A gene encoding a polydnavirus structural polypeptide is not encapsidated What does structure tell us about virus evolution? cord-000012-p56v8wi1 redox considerations for HIV and SARS- coronavirus Genetic recombination of the DNA plant virus PBCV-1 in a chlorella alga Common origin of four diverse families of large eukaryotic DNA viruses Evolutionary genomics of nucleo- cytoplasmic large DNA viruses Effects of the nonoccluded virus of Spodoptera frugiperda( Lepidoptera: Noctuidae) on the development of a parasitoid Parasitoid- mediated transmission of an iridescent virus Non- poly- DNA viruses, their parasitic wasp, and hosts The few virus- like genes of Cotesia congragata Self- synthesizing DNA transposons in eukaryotes Marvericks, a novel class of giant transposable elements widespread in eukaryotes and related to DNA viruses Evolution of viruses by acquisition of cellular RNA or DNA nucleotide sequences and genes: an introduction Microbialgenes in the human genome: lateral transfer or gene loss? cord-023647-dlqs8ay9 If and Sequence Similarity to Yeast Pt~2 StguCttU'e and Evolution of the 02 Small Nuclear RNA Multigene Family in Primates: Gene Amplification Under Nat-¢wal Selectinn? cord-023647-dlqs8ay9 Transcription Factors An Element of Symmetry in Ytmst TATA- box Binding Protein Transcription Factor- liD--Consequence of an Ancestra/ Duplication? cord-253987-83h861lp bioRxiv Could the D614 G substitution in the SARS- CoV-2 spike( S) protein be associated with higher COVID-19 mortality? cord-254107-02bik024 Are homology models of G- protein- coupled receptors suitable targets? cord-011184-ohdukhqt ( Theobroma cacao L.) autolysates Is there a role for α- glucosidase inhibitors in the prevention of type 2 diabetes mellitus? cord-011184-ohdukhqt Is the oral route possible for peptide and protein drug delivery? cord-011184-ohdukhqt Somatostatin- like material is present in flowering plants Research progress in structure- activity relationship of bioactive peptides Peptides: new signalling molecules in plants Identification of the bioactive and consensus peptide motif from Momordica charantia insulin receptor- binding protein Peptides as drugs: is there a market? cord-020235-stcrozdw Are the sites of insertion of viral DNA specific? 2. cord-020235-stcrozdw What type of recombinatorial events occur in viral DNA integration? cord-023208-w99gc5nx Are aza- β3 amino acids γ- turn mimetics? cord-023208-w99gc5nx These cells were multilayered on day-3 and expressed various keratinocyte markers, including cytokeratin-1, involculin, and laminin? cord-014852-6friw2ek A key control point in nuclear transport? cord-014852-6friw2ek Nucleocytoplasmic transport and beyond Snapshots of nuclear pore complexes in action captured by cryo electron tomography Yeast nuclear pore complexes have a cytoplasmic ring and internal fila ments Transport between the cell nucleus and the cytoplasm Cell cycle dependent dynamics of nuclear pores: Pore free islands and lamins The nuclear pore complex: Oily spa ghetti or gummy bear? cord-014852-6friw2ek Regulation of nuclear transport: Central role in development and transfor mation? cord-104282-90t1m430 might the ER- targeting sequence function? cord-010604-3d37o05y Adaptive posttranslational control in cellular stress response pathways and its relationship to toxicity testing and safety assessment Mechanisms of stress in the brain Post- translational modifications of the mineralocorticoid receptor: how to dress the receptor according to the circumstances? cord-010604-3d37o05y Peptidylprolylisomerases, protein folders or scaffolders? cord-010604-3d37o05y immunophilin FKBP51 forms complexes with hTERT enhancing telomerase activity Fkbp51 immunohistochemical expression: a new prognostic biomarker for OSCC? cord-171099-d0qr84xg A series of PDB related databases for everyday needs Structure and stability of the lamin A tail domain and HGPS mutant Evaluating Hierarchical Structure in Music Annotations Sounds interesting: can sonification help us design new proteins? cord-252536-gfx4cq03 Gene therapy for obesity? cord-016448-7imgztwe How many PPIs exist in a living cell? cord-016448-7imgztwe The yeast genome encodes approximately 6300 gene products which means that the maximal possible number of interacting protein pairs in this organism is close to 40 million, but what part of these potential interactions are actually realized in nature? cord-016448-7imgztwe Why do hubs tend to be essential in protein networks? cord-001244-qdld7hdc During the process of developing drugs against these diseases by targeting NRs, we are often facing a problem: Given a NR and chemical compound, can we identify whether they are really in interaction with each other in a cell? cord-001244-qdld7hdc Facing such a dilemma, can we find an approach to partially incorporate the sequence- order effects? cord-001244-qdld7hdc What are genetic studies telling us their role in renal life? cord-001244-qdld7hdc correlative effect Does the folding type of a protein depend on its amino acid composition? cord-021772-5v4gor2v Clinical and clinicopathological features of non- suppurative meningoencephalitis in young greyhounds in Ireland Cerebrospinal fluid eosinophilia in dogs What is your diagnosis? cord-021772-5v4gor2v What is your diagnosis? cord-261472-qcu73sdu Why arenatively unfolded"proteins unstructured under physiologic conditions? |
| cord-022955-vy0qgtll | A key question is how is the multi- ubiquitin chain is recognized as a signal? |
| cord-022955-vy0qgtll | Is this brain protease involved in the pathomechanism of multiple sclerosis? |
| cord-031937-qhlatg84 | Clostridium difficile: an under- recognized cause of reactive arthritis? |
| cord-031937-qhlatg84 | how do classical and non- classical HLA alleles modulate immune response to human immunodeficiency virus and hepatitis C virus infections? |
| cord-254957-jqp1gto6 | Given Twice Daily 640 to Patients With Advanced Solid Tumors Measurement of sorafenib plasma concentration by highperformance liquid chromatography in patients with advanced hepatocellular carcinoma: is it useful the application in clinical practice? |
| cord-003435-ke0az7nf | + regulatory T cells in the human immune system Human dendritic cell subsets: an update Correlates of protection induced by vaccination Cancer immunotherapy via dendritic cells Recombinant snakebite antivenoms: a cost- competitive solution to a neglected tropical disease? |
| cord-003435-ke0az7nf | , what's important? |
| cord-003435-ke0az7nf | Safer and virus- free? |
| cord-003435-ke0az7nf | Where are the advantages of using mRNA for antibody immunotherapies? |
| cord-258489-pyfc7jde | Cowpea mosaic virus- based systems for the production of antigens and antibodies in plants Is the infiltration- centrifugation technique appropriate for the isolation of apoplastic fluid? |
| cord-258624-041cf99j | What is the predictive value of animal models for vaccine efficacy in humans? |
| cord-150183-zzzyewjb | Different Epidemic Curves for Severe Acute Respiratory Syndrome Reveal Similar Impacts of Control Measures Virus batters some areas, why does it spare others? |
| cord-150183-zzzyewjb | How important is the fractal MZ scale? |
| cord-256047-mabrmzd9 | Deubiquitinating Enzymes Related to Autophagy: New Therapeutic Opportunities? |
| cord-006860-a3b8hyyr | ( platelet count< I50/~L) or a relative decrease in platelet count(? |
| cord-006860-a3b8hyyr | The examination reveals, that Fg- Au was present in a low density on the platelet surface, in higher density in the surface connected system( SCS), in coated pits and vesicles and separated smooth vesicles( representing endosomes?) |
| cord-006860-a3b8hyyr | The superpositisn of hepatitis infections on the treatment with blood and native blood products in most of the cases has let unanswered the question related to the mechanism of the immunodeficiency: the hepatitis B or C infections or the negative impact of the itarative important alloantigenlc load? |
| cord-253844-y6xdcf20 | SARS coronavirus entry into host cells through a novel clathrin- and caveolae- independent endocytic pathway Targeting the endocytic pathway and autophagy process as a novel therapeutic strategy in COVID-19 The lung macrophage in SARS- CoV-2 infection: a friend or a foe? |
| cord-253844-y6xdcf20 | why 2 meters/6 feet of inter- personal distance could not be enough Consideration of the aerosol transmission for COVID-19 and public health Asymptomatic carriage and transmission of SARS- CoV-2: what do we know? |
| cord-254909-8zgvovu4 | Does activation of the blood coagulation cascade have a role in malaria pathogenesis? |
| cord-029747-8f463wz0 | A reversible mechanism of electrophile signaling? |
| cord-029747-8f463wz0 | Providing cellular signpostspost- translational modifications of intermediate filaments Detection, identification, and quantification of oxidative protein modifications Proteome oxidative modifications and impairment of specific metabolic pathways during cellular senescence and aging Quantitative proteomic characterization of redox- dependent post- translational modifications on protein cysteines Activity- based sensing for site- specific proteomic analysis of cysteine oxidation Protein oxidation and peroxidation Lipoxidation targets: from basic mechanisms to pathophysiology Oxidized protein aggregates: formation and biological effects, Free Radic Lipoxidation adducts with peptides and proteins: deleterious modifications or signalling mechanisms? |
| cord-014685-ihh30q6f | How important is protein exibility for transport through ion channels? |
| cord-014685-ihh30q6f | Should it be the autonomous course or the part of physiology and radiology courses in the problem based learning approach?! |
| cord-014685-ihh30q6f | The consistency in the formations of these conformations makes the design of peptides with alpha, beta? |
| cord-014685-ihh30q6f | a tug- ofwar or coordinated movement? |
| cord-256325-q70rky3r | This raises the question: do henipavirus M proteins traffic through the nucleolus for other reasons? |
| cord-259260-qcfgigga | Vimentin: Central hub in EMT induction? |
| cord-262904-0b0ljjq1 | Learn more biomedcentral.com/submissions Ready to submit your research Ready to submit your research? |
| cord-103430-x6zzuu7v | A Worldwide Emerging Threat? |
| cord-103430-x6zzuu7v | An Outbreak of Human Semliki Forest Virus Infections in Central African 13 Isolation of a 15 newly recognized alphavirus from mosquitoes in Vietnam and evidence for human infection 16 and disease Me Tri virus: a Semliki Forest virus strain from Vietnam? |
| cord-103430-x6zzuu7v | The molecular pathogenesis of Semliki Forest 9 virus: a model virus made useful? |
| cord-018647-bveks6t1 | Are the biochemical reaction products electroactive? |
| cord-018647-bveks6t1 | Is one of the substrates or cofactors electrically active? |
| cord-018647-bveks6t1 | The main considerations are: Does the enzyme contain active redox groups? |
| cord-018647-bveks6t1 | What is the final application of NBSs? |
| cord-018647-bveks6t1 | What is the speed and response time? |
| cord-256156-mywhe6w9 | How good is automated protein docking? |
| cord-256156-mywhe6w9 | True Receptors or Adaptation Bias? |
| cord-262748-v4xue7ha | Virus membrane- fusion proteins: more than one way to make a hairpin Can self- inhibitory peptides be derived from the interfaces of globular protein- protein interactions? |
| cord-017887-pj6pal35 | Does the NMR structure, solved in the absence of Ca 2+ and inhibitors, represent the open or closed state of the channel( if the two states exist)? |
| cord-017887-pj6pal35 | How strong is the Ca 2+ selectivity of p7? |
| cord-017887-pj6pal35 | In the cases of the flu HA and HIV gp41, for example, new experiments need to be designed to address questions such as,"Does the TMD interact with the fusion domain in the hemifusion stage in which the two domains are presumably in close proximity?" |
| cord-017887-pj6pal35 | Or was p7 developed as a general, unspecific cation channel for the purpose of dissipating membrane potential? |
| cord-017887-pj6pal35 | and"Does the TMD play a role in facilitating the conversion from the hemifusion to the pore formation? |
| cord-023026-2r84ndzv | Does transplantation of healthy endothelial cells have a beneficial effect on the outcome of ischemic brain damage? |
| cord-260057-2m6jdvtc | COVID-19) Sars- Cov-2 interference in HEME production: is it the time for an early predictive biomarker? |
| cord-034823-ogwjzfgf | For example, if an amino acid has an ID score of 0.5, is it an ordered or disordered residue? |
| cord-034823-ogwjzfgf | Similarly, for a protein with 50% disordered residues, is it an ordered or disordered protein? |
| cord-034823-ogwjzfgf | The meaning of biological information What is information? |
| cord-034823-ogwjzfgf | What's in a name? |
| cord-265087-g4k6pc82 | Steady- state reaction system Review: steady- state inhibition kinetics of processive nucleic acid polymerases and nucleases Do antisense proteins exist? |
| cord-270594-62xotol3 | Why VP7 exited various protein expression patterns among virion, infected cells and larvae? |
| cord-263315-g7os15m1 | Can Anopheles Gambiae Be Infected with Wolbachia Pipientis? |
| cord-031957-df4luh5v | Rapid and sensitive sequence comparison with FASTP and FASTA Comparative analysis of the quality of a global algorithm and a local algorithm for alignment of two sequences Programming techniques: regular expression search algorithm Profile hidden Markov models Hidden Markov models and their applications in biological sequence analysis What are the ideal properties for functional food peptides with antihypertensive effect? |
| cord-031957-df4luh5v | parvifolia Isolation, solution structure, and insecticidal activity of kalata B2, a circular protein with a twist: do Möbius strips exist in nature? |
| cord-031957-df4luh5v | pore formers or metabolic inhibitors in bacteria? |
| cord-193133-puqcbf8t | Can companion animals become infected with COVID-19? |
| cord-193133-puqcbf8t | Can companion animals become infected with COVID-19? |
| cord-193133-puqcbf8t | What Does Plant- Based Vaccine Technology Offer to the Fight against COVID-19? |
| cord-005034-wyipzwo4 | A number of glycosyltransferases have restricted distributions within the Golgi apparatus, notably/~1,4 galactosyltransferase(/? 1,4GalT) |
| cord-005034-wyipzwo4 | How could the three domains of a glycosyltransferase play a role in aggregation? |
| cord-005034-wyipzwo4 | What are the possible mechanisms for the compartmentspecific localization of the membrane- bound glycosyltransferases? |
| cord-005034-wyipzwo4 | What could be the basis of an active Golgi retention mechanism? |
| cord-005034-wyipzwo4 | What do we know about the sorting signals and mechanisms for the localization of non- Golgi proteins within the secretory and endocytic pathways? |
| cord-274366-t138l6px | How deadly is COVID-19? |
| cord-002967-yy3bennu | Branchedchain amino acids: the best compromise to achieve anabolism? |
| cord-002967-yy3bennu | Cancer cachexia and diabetes: similarities in metabolic alterations and possible treatment Central tenet of cancer cachexia therapy: do patients with advanced cancer have exploitable anabolic potential? |
| cord-002967-yy3bennu | Hypothesis: muscular glutamine deficiency in sepsis- a necessary step for a hibernation- like state? |
| cord-002967-yy3bennu | Muscle UCP-3 mRNA levels are elevated in weight loss associated with gastrointestinal adenocarcinoma in humans Mitochondrial and sarcoplasmic reticulum abnormalities in cancer cachexia: altered energetic efficiency? |
| cord-002967-yy3bennu | Protein anabolic resistance in cancer IGF-1 is downregulated in experimental cancer cachexia Muscle atrophy in experimental cancer cachexia: is the IGF-1 signaling pathway involved? |
| cord-008556-oetrdm8g | Can ACG serve as an initiation codon for protein synthesis in eukaryotic cells? |
| cord-008556-oetrdm8g | How do eucaryotic ribosomes select initiation regions in messenger RNA? |
| cord-008556-oetrdm8g | Poliovirus protease does not mediate cleavage of the 220,000-Da component of the cap binding protein complex Translational control of protein synthesis after infection by VSV VSV mRNA and inhibition of translation of cellular mRNA- is there a P function in VSV? |
| cord-008556-oetrdm8g | What if complementation were to require, in addition to enu, a second minor protein- either a truncated form of enu that initiates a little farther downstream or a small protein encoded in an alternate reading frame? |
| cord-008556-oetrdm8g | What mechanism enables influenza mRNAs to bypass the block that retains host mRNAs in the nucleus? |
| cord-264392-he1vekrt | The gene start, stop and IGR sequences of NarPV are listed in Table 2( shown as cDNA sequence in the antigenome 5 0? |
| cord-264392-he1vekrt | and V(? 1 G) b |
| cord-010260-8lnpujip | Consensus regions with preferred conformation in homologous proteins Prediction of protein secondary structure at better than 70% accuracy Secondary structure prediction of all- helical proteins in two states PHD-An automatic mail server for protein secondary structure prediction Progress in protein structure prediction? |
| cord-010260-8lnpujip | How can these cases be identified in a reliable way? |
| cord-010260-8lnpujip | How do serine proteases really work? |
| cord-010260-8lnpujip | Predicting protein secondary structure with a nearest- neighbor algorithm Database of homologyderived protein structures and the structural meaning of sequence alignment An winexpensive, versatile sample illuminator for photo- CIDNP on any NMR spectrometer Pancreatic lipases: Evolutionary intermediates in a positional change of catalytic carboxylates? |
| cord-010260-8lnpujip | Some central questions arise: Do we know enough to undertake such tasks, and what goals can we define? |
| cord-010260-8lnpujip | Will future computers be all wet? |
| cord-262043-66qle52a | bioRxiv Is it reliable to use common molecular docking methods for comparing the binding affinities of enantiomer pairs for their protein target? |
| cord-262043-66qle52a | protein Are scoring functions in protein Àprotein docking ready to predict interactomes? |
| cord-276966-wmelyonk | Which viral pathogens or virus infected cells are susceptible to memory T cell and memory B cells? |
| cord-269011-230p8rsf | How, in the face of this enormous flexibility in accommodating all these various numbers and combinations of viral components, do coronaviruses manage to maintain specificity? |
| cord-281005-6gi18vka | Why are RNA virus mutation rates so damn high? |
| cord-017817-ztp7w9yh | Bacteria, the endoplasmic reticulum and the unfolded protein response: friends or foes? |
| cord-017817-ztp7w9yh | Endocytosis and autophagy: exploitation or cooperation? |
| cord-017817-ztp7w9yh | How can this be? |
| cord-017817-ztp7w9yh | Such"ROS- induced ROS release"might permit small ROS signals generated by mitochondria to activate ROS signalling throughout the cell, thereby avoiding mitochondrial damage that might arise if the entire cellular oxidant signal originated from that organelle[ 83]( or even leading to excessive ROS production?). |
| cord-017817-ztp7w9yh | What's the damage? |
| cord-017817-ztp7w9yh | an essential component of universal oxygen sensing machinery? |
| cord-260345-ugd8kkor | ( 1992) H ow does photodynamic therapy work? |
| cord-260345-ugd8kkor | ~e growth factor? |
| cord-271693-7tg21up3 | For instance, when clustering single- cell transcriptomes, is the analysis tuned to discover broad or specific cell types? |
| cord-264031-0y7xbgun | I deficiency? |
| cord-264031-0y7xbgun | Who is most likely to be infected with SARS- CoV-2? |
| cord-272241-2fwz8z8n | the beginning of another SARS- like pandemic? |
| cord-279463-bli8hwda | How can we possibly explain how the deletion of the cytoplasmic, hydrophilic segment from IyCAT reveals a cleavable signal sequence in a formerly membranespanning region? |
| cord-266977-5swwc6kr | Diathermy forceps and pencils: reservoirs for 349 protein and prion contamination? |
| cord-274080-884x48on | Molecular mechanism of divalentmetal- induced activation of NS3 helicase and insights into Zika virus inhibitor design HCV infection by cell- to- cell transmission: choice or necessity? |
| cord-274080-884x48on | Novel ESCRT functions in cell biology: spiraling out of control? |
| cord-272467-8heg5iql | How are these proteins confined to their appropriate destinations, rather than migrating onward to the plasma membrane? |
| cord-272467-8heg5iql | What features of each protein might be involved in determining its intracellular destination, and what are the mechanisms involved in each case? |
| cord-266617-z8uecyl6 | Origins of genes:"big bang"or continuous creation? |
| cord-266617-z8uecyl6 | Positive selection or free to vary? |
| cord-277293-eo3bei9x | encodes a unique replication protein having both plasmid- and virus- like domains: clue to viral ancestry or result of virus/ plasmid recombination? |
| cord-022235-6ircruag | Do polarized cells sort and direct proteins directly to their target mem branes, or are they all first randomly targeted to both domains, or specifi cally to one or other domain, and then transcytosed? |
| cord-022235-6ircruag | How are proteins specifically retained in individual Golgi cisternae? |
| cord-022235-6ircruag | How then do secretory proteins move between these compart ments, and is the secretory pathway a continuous gradient of secretory organelles or are they functionally and structurally independent? |
| cord-022235-6ircruag | This raises two of the fundamental questions which will be addressed in this chapter, namely, what determines whether a protein will be taken out of circulation at a particular step in the pathway, and how tight is the separation between secretory organelles? |
| cord-022235-6ircruag | What happens to incorrectly folded proteins in the ER? |
| cord-279691-v5kpmk0b | How are the nsps of CoVs able to induce the observed membrane rearrangements? |
| cord-004948-ad3i9wgj | A dummy or a protagonist on the stage of inflammation? |
| cord-004948-ad3i9wgj | A dummy or a protagonist on the stage of inflammation? |
| cord-004948-ad3i9wgj | Brain α- endosulfine is manifold decreased in brains from patients with Alzheimer's disease: a tentative marker? and drug target? |
| cord-004948-ad3i9wgj | Brain α- endosulfine is manifold decreased in brains from patients with Alzheimer's disease: a tentative marker? and drug target? |
| cord-004948-ad3i9wgj | The initial question that interested us was what makes a di/ tri- peptide a substrate, but not an amino acid? |
| cord-004948-ad3i9wgj | Why are we interested in this? |
| cord-280679-jj3wzojy | How important is the molten globule for correct protein folding? |
| cord-268239-neb6xxlf | Quo vadis? |
| cord-268239-neb6xxlf | What about the used technique along the time? |
| cord-270587-k56fze59 | Lewisx Benefits from a Nonconventional C- H···O Hydrogen Bond Is N- acetyl- d- glucosamine a rigid 4C1 chair? |
| cord-270587-k56fze59 | So you think computational approaches to understanding glycosaminoglycan- protein interactions are too dry and too rigid? |
| cord-279418-3r1ijafm | Endoplasmic Reticulum- Golgi Intermediate Compartment Membranes and Vimentin Filaments Participate in Vaccinia Virus Assembly Replication of African Swine Fever Virus DNA in Infected Cells Cytoplasmic Organization of POXvirus DNA Replication Aggresomes and Pericentriolar Sites of Virus Assembly: Cellular Defense or Viral Design? |
| cord-279418-3r1ijafm | This arrangement leads to the interaction of both( n+1) th Virus factories: associations of cell organelles for viral replication and morphogenesis Virus factories, double membrane vesicles and viroplasm generated in animal cells Virus factories: biogenesis and structural design Biomolecular condensates: organizers of cellular biochemistry Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/ Condensation Droplet organelles? |
| cord-286219-qcx5ehnh | What has the study of the K3 and K5 viral ubiquitin E3 ligases taught us about ubiquitin- mediated receptor regulation? |
| cord-252304-lwiulri7 | Interactions between coagulation and complement- their role in inflammation Comparison of the transcriptional profiles of patients with dengue fever and dengue hemorrhagic fever reveals differences in the immune response and clues in immunopathogenesis Serum proteome changes in dengue virus- infected patients from a dengueendemic area of India: towards new molecular targets? |
| cord-252304-lwiulri7 | The host complement system and arbovirus pathogenesis Correlation between complement component levels and disease severity in dengue patients in Indonesia Hemostatic defects in dengue hemorrhagic fever Is clinical outcome of dengue- virus infections influenced by coagulation and fibrinolysis? |
| cord-252304-lwiulri7 | Why dengue haemorrhagic fever in Cuba? |
| cord-252304-lwiulri7 | potential implications in haemorrhagic fever pathogenesis Molecular mimicry between virus and host and its implications for dengue disease pathogenesis Complement and dengue haemorrhagic fever/ shock syndrome Expression of cytokine, chemokine, and adhesion molecules during endothelial cell activation induced by antibodies against dengue virus nonstructural protein 1 Vascular leakage in severe dengue virus infections: a potential role for the nonstructural viral protein NS1 and complement Differential gene expression changes in children with severe dengue virus infections Antagonism of the complement component C4 by flavivirus nonstructural protein NS1 Binding of flavivirus nonstructural protein NS1 to C4b binding protein modulates complement activation Cytokine expression profile of dengue patients at different phases of illness Alteration of cytokines and chemokines during febrile episodes associated with endothelial cell damage and plasma leakage in dengue hemorrhagic fever Predicting outcome from dengue Relationship of preexisting dengue virus( DV) neutralizing antibody levels to viremia and severity of disease in a prospective cohort study of DV infection in Thailand Dengue viremia titer, antibody response pattern, and virus serotype correlate with disease severity Do escape mutants explain rapid increases in dengue case- fatality rates within epidemics? |
| cord-252304-lwiulri7 | the hepatic acute phase response Complement factor B gene regulation: synergistic effects of TNF- alpha and IFN- gamma in macrophages Complement and coagulation: strangers or partners in crime? |
| cord-287477-aios0h8s | How can CoV-2 divert them to its advantage? |
| cord-262585-5vjqrnwh | For example, can some viral peptides be useful as adjuvants? |
| cord-262585-5vjqrnwh | What specific constraints limit SLiM evolvability? |
| cord-262585-5vjqrnwh | in the design of vaccines and therapies to promote global health? |
| cord-286301-7sjw5ci7 | A mechanism of virus- induced demyelination COPI in ER/ Golgi and intra- Golgi transport: do yeast COPI mutants point the way? |
| cord-254100-u6x5zd4i | An umbraviral protein, involved in long- distance RNA movement, binds viral RNA and forms unique, protective ribonucleoprotein complexes Eukaryotic elongation factor 1A interacts with Turnip mosaic virus RNA- dependent RNA polymerase and VPg- Pro in virus- induced vesicles Regulation of host cell translation by viruses and effects on cell function Insights into nuclear organisation in plants as revealed by the dynamic distribution of Arabidopsis SR splicing factors Evolutionary origins of the RNA- guided nucleotide- modification complexes: from the primitive translation apparatus? |
| cord-254100-u6x5zd4i | The capsid protein of satellite panicum mosaic virus contributes to systemic invasion and interacts with its helper virus Getting the message across: How do plant cells exchange macromolecular complexes? |
| cord-254100-u6x5zd4i | The nucleolus-a gateway to viral infection? |
| cord-254100-u6x5zd4i | What's new in the nucleolus? |
| cord-254100-u6x5zd4i | viroid RNA in vitro and in vivo Pumpimg RNA: Nuclear bodybuilding along the RNP pipeline Nuclear bodies: random aggregates of sticky proteins or crucibles of macromolecular assembly? |
| cord-280360-rh37d5wc | -I infiltration in rheumatoid arthritis synovial tissue: a control mechanism of cytokine production? |
| cord-280360-rh37d5wc | Worldwide prevalence of juvenile arthritis: why does it vary so much? |
| cord-284648-yznlgzir | Biomedical applications of tunable biopolymers Molecular Description of the LCST Behavior of an Elastin- Like Polypeptide UCST and LCST behavior in polymer blends A unified model for de novo design of elastin- like polypeptides with tunable inverse transition temperatures Temperature dependence of length of elastin and its polypentapeptide Effect of protein fusion on the transition temperature of an environmentally responsive elastin- like polypeptide: a role for surface hydrophobicity? |
| cord-290290-wyx9ib7s | gp120 Interactions with alpha4beta7 Structure, Function, and Antigenicity of the SARS- CoV-2 Spike Glycoprotein Testing for responses to the wrong SARS- CoV-2 antigen? |
| cord-279629-t1xjy12y | An evolutionary RGD motif in the spike protein of SARS- CoV-2 may serve as a potential high risk factor for virus infection? |
| cord-279629-t1xjy12y | When will a coronavirus vaccine be ready?". |
| cord-284990-klsl1nzn | The ESAT-6/ WXG100 superfamily- and a new Gram- positive secretion system? |
| cord-004534-jqm1hxps | -Single molecule biophysics- Is there a specific erythrocyte membrane receptor for fibrinogen? |
| cord-004534-jqm1hxps | A generalized quantitative FRAP method with no restriction on the size of the photobleached area Heterochromatin protein 1 in DNA damage response-recruitment or dissociation from repair sites? |
| cord-004534-jqm1hxps | Application of the methodology to binding of various aromatic drugs with DNA provides an answer to the question'What forces are the main contributors to the stabilization of aromatic ligand- DNA complexes'? |
| cord-004534-jqm1hxps | Do retinal rod outer segments carry out oxydative phosphorylation? |
| cord-004534-jqm1hxps | Does the lysosomal membrane need triglycerides? |
| cord-004534-jqm1hxps | What about the force? |
| cord-004534-jqm1hxps | pN. Pushing on microtubules: dominant spindle centering mechanism in C. elegans embryo? |
| cord-294575-kky8j9oy | Can Proteomics Tell Us about Tuberculosis? |
| cord-004879-pgyzluwp | A50$ 14- 28 Neutralization rates of TNF- a from eight animal species by a monoclonal antibody against human TNF: implication for receptor action? |
| cord-004879-pgyzluwp | Are these two activities encoded by a single mRNA? |
| cord-004879-pgyzluwp | Do their protein- chemical structure and organisation decipher us certain clues and parts of the path by which they have been selected and derived from a possible primordial reaction centre polypeptide? |
| cord-004879-pgyzluwp | Does the ALEP1 germ- line specific protein have a homologue in the somatic ribosomes? |
| cord-004879-pgyzluwp | However, in the presence of 1000 U/ ml interferon? |
| cord-004879-pgyzluwp | Is membranebound enzyme preferentially associated with a given cellular membrane? |
| cord-004879-pgyzluwp | What is the function of rpS 19? |
| cord-295381-0dqu3p3y | Why do Hsp90 inhibitor drugs selectively kill cancer cells, even though Hsp90 is widely expressed in normal tissues? |
| cord-265887-g5zhoyo9 | Alternatively, does the lipid- composition specificity of the C- terminal determine the conformational uptake and the eventual functional topology? |
| cord-265887-g5zhoyo9 | Do these hydrophobic interactions prompt the downstream oligomerization events to the formation of the membrane- associated multimers? |
| cord-265887-g5zhoyo9 | Does the C- terminal induce the initial docking of the protein to the host membranes? |
| cord-253466-7gpije5d | , 2004) induces vesicles and dispersal of the Golgi apparatus, which begs the questions, does this mutant use a different process for forming the replication complex, or do the mutations in 3A allow the proteins to compete with BFA for GBF1 recruitment? |
| cord-253466-7gpije5d | African swine fever virus is wrapped by the endoplasmic reticulum Cellular COPII proteins are involved in production of the vesicles that form the poliovirus replication complex Vaccinia virus membrane proteins p8 and p16 are cotranslationally inserted into the rough endoplasmic reticulum and retained in the intermediate compartment Daxx: Death or survival protein? |
| cord-253466-7gpije5d | Biogenesis from scratch? |
| cord-253466-7gpije5d | Hijacking components of the secretory pathway for replication of poliovirus RNA Does common architecture reveal a viral lineage spanning all three domains of life? |
| cord-253466-7gpije5d | Viral interactions with the cytoskeleton of mammalian cells Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex Assembly of vaccinia virus revisited: De novo membrane synthesis or acquisition from the host? |
| cord-034406-i1hbx3pz | Ansun Biopharma enrolls first patient in proof of concept trial of DAS181 for the treatment of COVID-19 Direct administration in the respiratory tract improves efficacy of broadly neutralizing anti- influenza virus monoclonal antibodies In a murine model of acute lung infection, airway administration of a therapeutic antibody confers greater protection than parenteral administration Challenges and future prospects for the delivery of biologics: oral mucosal, pulmonary, and transdermal routes Non- invasive delivery strategies for biologics Idealhalers versus realhalers: is it possible to bypass deposition in the upper respiratory tract? |
| cord-034406-i1hbx3pz | I- particles of sugar excipients( trehalose and raffinose) for protein delivery Dry powders of stable protein formulations from aqueous solutions prepared using supercritical CO2-assisted aerosolization Mechanisms of protein stabilization in the solid state Stabilisation of proteins via mixtures of amino acids during spray drying Amorphous powders for inhalation drug delivery PEGylation, an approach for improving the pulmonary delivery of biopharmaceuticals What is the future of PEGylated therapies? |
| cord-034406-i1hbx3pz | Protalix BioTherapeutics Designing inhaled protein therapeutics for topical lung delivery: what are the next steps? |
| cord-034406-i1hbx3pz | The inhibition of phagocytosis of respirable microspheres by alveolar and peritoneal macrophages Distribution and cellular uptake of PEGylated polymeric particles in the lung towards cell- specific targeted delivery Drug delivery for tuberculosis: is inhaled therapy the key to success? |
| cord-034406-i1hbx3pz | The penetration of fresh undiluted sputum expectorated by cystic fibrosis patients by non- adhesive polymer nanoparticles Preclinical models for pulmonary drug delivery Formulation technology to repurpose drugs for inhalation delivery Will pulmonary drug delivery for systemic application ever fulfill its rich promise? |
| cord-004435-l66ost6q | 2020:9 Time for T? |
| cord-004435-l66ost6q | An update and perspective Progress and challenges in TB vaccine development Vaccines for the elderly: current use and future challenges Remembrance of things past: long- term B cell memory after infection and vaccination Global practices of meningococcal vaccine use and impact on invasive disease New vaccine technologies to combat outbreak situations What are the most powerful immunogen design vaccine strategies? |
| cord-004435-l66ost6q | Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges Evaluation of levamisole as an adjuvant for typhoid fever vaccine formulation HLA and infectious diseases Predicting antigen presentation- what could we learn from a million peptides? |
| cord-004435-l66ost6q | How does the VSG coat of bloodstream form African trypanosomes interact with external proteins? |
| cord-004435-l66ost6q | The use of databases, data mining and immunoinformatics in vaccinology: where are we? |
| cord-004435-l66ost6q | Vaccines( Basel) Recalling the future: immunological memory toward unpredictable influenza viruses Human leukocyte antigen( HLA)-binding epitopes dataset for the newly identified T- cell antigens of Mycobacterium immunogenum Fundamentals and methods for T- and B- cell epitope prediction Human Leukocyte Antigen( HLA) and immune regulation: how do classical and non- classical HLA alleles modulate immune response to human immunodeficiency virus and hepatitis C virus infections? |
| cord-004435-l66ost6q | and what are the potential clinical implications? |
| cord-004435-l66ost6q | faster de novo structure prediction for linear peptides in solution and in complex The Protein Model Portal- a comprehensive resource for protein structure and model information Exploring Leishmania secretory proteins to design B and T cell multi- epitope subunit vaccine using immunoinformatics approach AP-1 transcription factors as regulators of immune responses in cancer Vaccinomics and personalized vaccinology: is science leading us toward a new path of directed vaccine development and discovery? |
| cord-294677-l1b4mw9d | towards prediction paradise? |
| cord-296794-ml2luc1t | predicting the location of continuous epitopes and patterns in proteins Selection and combination of machine learning classifiers for prediction of linear B- cell epitopes on proteins Machine learning approaches for prediction of linear B- cell epitopes on proteins Predicting antigenic determinants in proteins: looking for unidimensional solutions to a three- dimensional problem? |
| cord-000257-ampip7od | For instance, how many gene encoding sequences are present in one genome? |
| cord-000257-ampip7od | How did alternative splicing evolve? |
| cord-000257-ampip7od | How frequent are correlated changes in families of protein sequences? |
| cord-000257-ampip7od | How many sequences are repetitive and are these sequences similar in the various organisms on Earth? |
| cord-000257-ampip7od | Is there any significant correlation between the propensity to distribute and the functional roles domains have in cellular pathways? |
| cord-000257-ampip7od | The linkage between protein folding and functional cooperativity: two sides of the same coin? |
| cord-000257-ampip7od | Which genes were involved in the large scale genome duplications that we see in animals? |
| cord-000257-ampip7od | Who's your neighbor? |
| cord-295351-0zr2e8lh | : why is this situation a PHEIC? |
| cord-282859-uxltqopq | The small heat shock protein, HSPB6, in muscle function and disease Protein quality control during aging involves recruitment of the macroautophagy pathway by BAG3 NF- kappaB a good target for cancer therapy? |
| cord-282859-uxltqopq | The stress- inducible HspB8-Bag3 complex induces the eIF2alpha kinase pathway: implications for protein quality control and viral factory degradation? |
| cord-294945-hcf7gsv8 | a balancing act? |
| cord-280878-1kt51viz | A new structural label for infrared spectroscopy Conductance and amantadine binding of a pore formed by a lysine- flanked transmembrane domain of SARS coronavirus envelope protein Model of a putative pore: The pentameric α- helical bundle of SARS coronavirus E protein in lipid bilayers Protein- protein interactions of viroporins in coronaviruses and paramyxoviruses: New targets for antivirals? |
| cord-280878-1kt51viz | The SARS coronavirus E protein interacts with PALS1 and alters tight junction formation and epithelial morphogenesis Functional role of human immunodeficiency virus type 1 vpu Detection of drug- induced conformational change of a transmembrane protein in lipid bilayers using site- directed spin labeling Do viral proteins possess unique biophysical features? |
| cord-280429-4fota9rl | A new DNA binding protein highly conserved in diverse crenarchaeal viruses Structure of A197 from Sulfolobus turreted icosahedral virus: A crenarchaeal viral glycosyltransferase exhibiting the GT- A fold The bacterial conjugation protein TrwB resembles ring helicases and F1-ATPase Structure of the VirB4 ATPase, alone and bound to the core complex of a type IV secretion system Polintons: A hotbed of eukaryotic virus, transposon and plasmid evolution Virophages or satellite viruses? |
| cord-280429-4fota9rl | Archaeal viruses: Living fossils of the ancient virosphere? |
| cord-280429-4fota9rl | What does structure tell us about virus evolution? |
| cord-298251-u36lb44w | ELMOD2 is an Arl2 GTPase- activating protein that also acts on Arfs Trafficking to the ciliary membrane: how to get across the periciliary diffusion barrier? |
| cord-300625-fvirvpyl | Can it be facilitated? |
| cord-287729-pl88otue | Could this be a conformationally active rcg)l, n of the coat protein that is exposed only in the nematode foregut and that acts as a cleavage site for virui release? |
| cord-287729-pl88otue | Jnd Hen?. |
| cord-259603-bh198xgl | 4 G is sufficient to support cap- independent translation in the absence of eIF4E Genome- wide analysis of protein- protein interactions and involvement of viral proteins in SARS- CoV replication Nidovirus transcription: how to make sen- se …? |
| cord-259603-bh198xgl | CORONAVIRUS nsp7- 10: SMALL BUT CRITICAL REGULATORY SUBUNITS? |
| cord-259603-bh198xgl | Clearly, both the role of nsp8( primase or processivity factor?) and the initiation mechanism employed by the nsp12-RdRp require further study. |
| cord-259603-bh198xgl | The broadspectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen Ribavirin's antiviral mechanism of action: lethal mutagenesis? 0 |
| cord-259603-bh198xgl | mRNA stability SARS coronavirus accessory proteins Biochemical characterization of arterivirus nonstructural protein 11 reveals the nidovirus- wide conservation of a replicative endoribonuclease Arterivirus Nsp1 modulates the accumulation of minus- strand templates to control the relative abundance of viral mRNAs Does form meet function in the coronavirus replicative organelle? |
| cord-286603-4p3t0vre | Cellular proteostasis during influenza A virus infection- Friend or Foe? |
| cord-286603-4p3t0vre | unfolded protein response Hemagglutininneuraminidase and fusion proteins of virulent Newcastle disease virus cooperatively disturb fusion- fission homeostasis to enhance mitochondrial function by activating the unfolded protein response of endoplasmic reticulum and mitochondrial stress Mechanisms for enveloped virus budding: can some viruses do without an ESCRT? |
| cord-023209-un2ysc2v | And, is Abeta modifi ed by 1( 2) able to aggregate at low concentrations on a biologically relevant time scale? |
| cord-023209-un2ysc2v | Because these compounds were rationally designed by using the co- crystallized structure of VEGF with the immunoglobulin like fragment 2 of VEGFR-1, we raise the following question: do these antagonists really target the immunoglobulin like domain 2 of VEGFR-1? |
| cord-023209-un2ysc2v | C more or less resistant to denaturation conditions? |
| cord-023209-un2ysc2v | Conformational preferences of investigated systems were obtained on base of ROESY and NOESY experiments and calculations by use of X- PLOR and quantum chemical calculation Is concentration overload or volume overload the best strategy for synthetic peptide purifi cation? |
| cord-023209-un2ysc2v | Peptido2.rotaxanes: can a tetramide macrocycle travel to a station by wrapping up around a helical peptide thread? |
| cord-023209-un2ysc2v | lower the CC of Abeta aggregation into the PC range? |
| cord-014368-4nasrbs6 | A typical search asks a question such as"What can be found out about the negative regulatory aspects of a genetic network in the pharynx?" |
| cord-014368-4nasrbs6 | But how realistic is this venture? |
| cord-014368-4nasrbs6 | But why stop there? |
| cord-014368-4nasrbs6 | If you have ever spent an evening hoisting brews with your pals at the corner pub, chances are you never stopped to think- gee, how do I lift my glass now that it's only half full? |
| cord-014368-4nasrbs6 | Running the same search three times on three different subsets of content might be better than running it 15 times- but would n't it be easier to run it just once? |
| cord-014368-4nasrbs6 | So naturally, neuroscientists wonder, does the architectural organization of the motor system reveal an underlying functional organization? |
| cord-014368-4nasrbs6 | The question is, how soon can these levels be achieved for biology? |
| cord-014368-4nasrbs6 | The question is, how soon can these levels be achieved for biology? |
| cord-298922-k568hlf4 | Gene ontology: tool for the unification of biology Mechanisms of coronavirus cell entry mediated by the viral spike protein Evolution of clinical proteomics and its role in medicine Detection and molecular diversity of spike gene of porcine epidemic diarrhea virus in China Molecular epidemiology of porcine epidemic diarrhea virus in China Isolation and characterization of porcine epidemic diarrhea viruses associated with the 2013 disease outbreak in US swine Interaction of West Nile virus with alpha v beta 3 integrin mediates virus entry into cells Inhibitory effects of recombinant human cystatin C on human coronaviruses Autophagy and viruses: adversaries or allies? |
| cord-302414-g5onwhg1 | The SARS- CoV-2 vaccine pipeline: an overview SARS vaccines: where are we? |
| cord-297960-4x1j0iqg | : can we ever expect the unexpected? |
| cord-297960-4x1j0iqg | How Do intrinsically disordered viral proteins hijack the cell? |
| cord-031907-ilhr3iu5 | Extracellular Vesicle- based liquid biopsy in Acute Myeloid Leukaemia: a reliable source of residual disease biomarkers? |
| cord-298369-66ifwtlp | Do we need to optimize plasma and tissue binding in drug discovery? |
| cord-018963-2lia97db | A fit well with structural fold B? |
| cord-018963-2lia97db | A fit well with structural fold B? |
| cord-018963-2lia97db | A unified statistical framework for sequence comparison and structure comparison Emergence of preferred structures in a simple model of protein folding Are protein folds atypical? |
| cord-018963-2lia97db | Bioinformatics in the driver's seat Prediction of transcription regulatory sites in Archaea by a comparative genomic approach Can sequence determine function? |
| cord-018963-2lia97db | How representative are the known structures of the proteins in a complete genome? |
| cord-018963-2lia97db | This observation has also raised an interesting question:"Is there something special about the topology of protein structures, which could be further and more rigorously exploited for efficient threading algorithm development?" |
| cord-018963-2lia97db | Why do globular proteins fit the limited set of folding patterns? |
| cord-307227-x6xketcn | New treatments for Zika virus infection? |
| cord-306733-df36w6l7 | What Does Plant- Based Vaccine Technology Offer to the Fight against COVID-19? |
| cord-300884-rqfxe0x1 | The papain- like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme Full- length human immunodeficiency virus type 1 genomes from subtype C- infected seroconverters in India, with evidence of intersubtype recombination A biochemical genomics approach for identifying genes by the activity of their products Localization of an RNA- binding domain in the nucleocapsid protein of the coronavirus mouse hepatitis virus Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure Discovery of an RNA virus 3′→5′ exoribonuclease that is critically involved in coronavirus RNA synthesis Characterization of the coronavirus M protein and nucleocapsid interaction in infected cells Characterization of N protein selfassociation in coronavirus ribonucleoprotein complexes Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites Nidovirus transcription: how to make sense …? |
| cord-304953-ntg8w5k4 | But what is the nature of this link? |
| cord-301128-woe6knpv | A fingerprint of DNA/ RNA demixing? |
| cord-301128-woe6knpv | The question that remains to be answered is consequently: What additional constraint must the DNA- bridging protein exert on its binding sites in order to preserve not only the difference in torsional stress between the two moieties of the DNA chain, but rather the precise initial torsional stress in each moiety? |
| cord-283096-qm7h4qui | : how close are the family ties? |
| cord-283096-qm7h4qui | I TLR3 in antiviral immunity: key player or bystander? |
| cord-283096-qm7h4qui | The interferon regulated ubiquitin- like protein, ISG15, in tumorigenesis: friend or foe? |
| cord-304306-rxjahqwh | Structural Differences Linked to Virus Characteristics? |
| cord-307811-6e3j0pn7 | Tissue specific distribution of sulfated mucopolysaccharides in mammals Bio- specific sequences and domains in heparan sulphate and the regulation of cell growth and adhesion Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates? |
| cord-307811-6e3j0pn7 | Would a rose by another name smell as sweet? |
| cord-312332-rwmuucsp | Do cellular RBPs participate in viral particle assembly? |
| cord-315531-2gc2dc46 | Ubiquitin- like proteins in prokaryotic cells? |
| cord-016594-lj0us1dq | Are high- scoring matches an artefact or are they real and meaningful? |
| cord-016594-lj0us1dq | But, is this practically useful for selecting candidate vaccines? |
| cord-016594-lj0us1dq | Have we cut ourselves too short in mapping CTL epitopes? |
| cord-016594-lj0us1dq | However, and say that we were offered a newly sequenced pathogen genome, is such a classification for AB toxins helpful when trying to identify a potential exotoxins? |
| cord-016594-lj0us1dq | The same old, familiar caveats apply here: are chosen thresholds appropriate? |
| cord-016594-lj0us1dq | This typically yields exact values for, say, the binding affinity of a peptide to a protein component of the immune system, or an unequivocal yes or no answer to the question: is this peptide sequence an epitope? |
| cord-016594-lj0us1dq | Using NERVE, the prioritisation of potential candidate antigens consists of several stages: prediction of subcellular localisation; is the antigen an adhesion?; identification of membrane- crossing domains; and comparison to pathogen and human proteomes. |
| cord-016594-lj0us1dq | Why should this be? |
| cord-016594-lj0us1dq | Why should this be? |
| cord-286217-3uklf2u2 | ( 2) Are there any other viral proteins that could trigger significant antibody responses in at least some of the patients? |
| cord-286217-3uklf2u2 | ( 3) Is it possible to link the magnitude of the overall IgG and IgM response to the severity of the disease in patients? |
| cord-286217-3uklf2u2 | What is the variation among different patients, especially for antibodies against the nucleocapsid protein( N protein) and S protein? |
| cord-315984-5gbhobw8 | HIV-1 reverse transcription initiation: a potential target for novel antivirals? |
| cord-264996-og3sg0qw | But how does a specific protein''know''how to reach a specific cellular destination when hundreds of newly synthesized, diVerent molecules require 2 specific transport and targeting? |
| cord-264996-og3sg0qw | The Next Generation of Medical Treatment? |
| cord-264996-og3sg0qw | The secrets of secretory lysosomes The biogenesis of lysosomes: Is it a kiss and run, continuous fusion and fission process? |
| cord-264996-og3sg0qw | This raises a key question: how do protein and lipid cargo move through the Golgi apparatus while resident enzymes retain their localization? |
| cord-264996-og3sg0qw | Where is it and what does it do? |
| cord-319609-y0gdjn64 | long- term surviving hemophiliacs HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV- infected long term nonprogressors Progression of HIV to AIDS: a protective role for HLA- B27? |
| cord-304607-td0776wj | Molecular detection of multiple emerging pathogens in sputa from cystic fibrosis patients ALLPATHS: de novo assembly of whole- genome shotgun microreads Evolution of pathogenicity and sexual reproduction in eight Candida genomes New tools for discovering and characterizing microbial diversity Cytolethal distending toxin( CDT): a bacterial weapon to control host cell proliferation? |
| cord-304607-td0776wj | The death of microarrays? |
| cord-318749-k91oku7h | How should we think about the ribosome? |
| cord-316983-h4mtpcyc | Venom proteins from parasitoid wasps and their biological functions Diversity of virus- like particles in parasitoids'venom: viral or cellular origin? |
| cord-267475-6f4h3cck | 25 kDa movement protein 12 and 8 kDa movement proteins f?? |
| cord-267475-6f4h3cck | 25 kDa movement protein 12 and 8 kDa movement proteins f?? |
| cord-267475-6f4h3cck | Do the 5 0 untranslated domains of human cDNAs challenge the rules for initiation of translation( or is it vice versa New ways of initiating translation in eukaryotes? |
| cord-267475-6f4h3cck | How does the 40S subunit hold on at a terminator codon, in order to reinitiate? |
| cord-267475-6f4h3cck | What drives migration of the 40S subunit during the scanning phase? |
| cord-267475-6f4h3cck | What prevents reinitiation when the size of the first ORF exceeds a certain length? |
| cord-319563-9lwr6k8p | Using 8-Anilino-1-naphthalenesulfonic Acid Manual Immunonephelometric Assay of Proteins, with Use of Polymer Enhancement Which method for quantifying urinary albumin excretion gives what outcome? |
| cord-300429-b0zev8zb | The role of MPP1/ p55 and its palmitoylation in resting state raft organization in HEL cells Membrane raft association is a determinant of plasma membrane localization Palmitoylated transmembrane adaptor proteins in leukocyte signaling Interaction of influenza virus haemagglutinin with sphingolipid- cholesterol membrane domains via its transmembrane domain What does S- palmitoylation do to membrane proteins? |
| cord-300429-b0zev8zb | are enzymes for fatty acid attachment promising drug targets? |
| cord-314642-oobbdgzh | First, if this and other'alien'DNA came from some distantly related donor species of bacteria, what was the donor? |
| cord-314642-oobbdgzh | Second, is the potential mobility of the element in its present host a significant factor in the epidemiology of the diseases? |
| cord-276988-bvsz5q6d | A novel tumor- related long non- coding RNA The biogenesis, biology and characterization of circular RNAs Mis- splicing yields circular RNA molecules Cell- type specific features of circular RNA expression Selective release of circRNAs in platelet- derived extracellular vesicles Human platelets and their capacity of binding viruses: Meaning and challenges? |
| cord-276988-bvsz5q6d | However, the most intriguing question is: How and where do platelets get their content from? |
| cord-276988-bvsz5q6d | However, the most intriguing question is: How and where do platelets get their content from? |
| cord-276988-bvsz5q6d | In vitro generation of platelets: Where do we stand? |
| cord-276988-bvsz5q6d | Nevertheless, the biological relevance of platelet circRNAs, if any, remains unclear: do they modulate platelet functions or are they simply byproducts of megakaryocyte transcription and platelet mRNA degradation? |
| cord-302490-em1tiz7s | Interfacial sensing by alveolar type II cells: A new concept in lung physiology? |
| cord-302490-em1tiz7s | The closer we look the more we see? |
| cord-322926-xlwsj3v2 | Recent progress in the development of plant derived vaccines Viral vectors for the expression of proteins in plants Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp Will plant- made biopharmaceuticals play a role in the fight against COVID-19? |
| cord-304616-k92fa15l | Species differences in drug plasma protein binding Selective plasma protein binding of antimalarial drugs to α1-acid glycoprotein Plasma protein binding and blood- free concentrations: which studies are needed to develop a drug? |
| cord-304616-k92fa15l | What is the true clinical significance of plasma protein binding displacement interactions? |
| cord-315570-khm1veuv | How Far From Clinical Use? |
| cord-020788-a33vcapl | Are different signals recognized by the different epithelial cells or is the same signal interpreted differently? |
| cord-020788-a33vcapl | But if the VSVG ectodomain is randomly secreted and the VSVG tail domain fused to HA is apical, which domain of VSVG encodes basolateral sorting information? |
| cord-020788-a33vcapl | For example, is this cell derived from a tissue specialized for apical secretion or apical endocytosis? |
| cord-020788-a33vcapl | For the epithelial cell biologist, the obvious question is,"What brings about the pathway- specific localizations of rab proteins in polarized epithelial cells?" |
| cord-020788-a33vcapl | Is the sorting machinery itself different between polarized cells, or is the sorting machinery basically conserved between different cell- types while its regulation, adaptation, or wiring to the targeting machinery is different? |
| cord-020788-a33vcapl | Is the tight junction a barrier to diffusion in the plasma membrane? |
| cord-020788-a33vcapl | What does the LDLR gain by expressing two basolateral localization signals? |
| cord-020788-a33vcapl | Why do these proteins need multiple signals? |
| cord-022888-dnsdg04n | /CRTAM on gd T cells? |
| cord-022888-dnsdg04n | As the results show, could there not be a direct relationship between the HLA system and the development of SA or TBC, or in contrast, was the first patient missdiagnosed of TBC being a good prognosis SA? |
| cord-022888-dnsdg04n | Could Carabin play a role of negative regulator of B cell function? |
| cord-022888-dnsdg04n | How is the IGSF4-CRTAM axis regulated in T cells? |
| cord-022888-dnsdg04n | a one- year prospective birth cohort study PC09/16 TO WHAT EXTENT T- SPOT.TB COULD BE USED IN THE DIAGNOSIS OF TUBERCULOSIS IN CHILDREN EXPOSED TO TB INFECTION? |
| cord-323768-r7jbm1et | Pea lectin expressed transgenically in oilseed rape reduces growth rate of pollen beetle larvae Plant- insect interactions: What can we learn from plant lectins? |
| cord-325043-vqjhiv7p | chance or common ancestry? |
| cord-310847-63gh2tg4 | Structural analysis of the Bacillus subtilis delta factor: a protein polyanion which displaces RNA from RNA polymerase MARCKS: a case of molecular exaptation? |
| cord-310847-63gh2tg4 | Why are"natively unfolded"proteins unstructured under physiologic conditions? |
| cord-310847-63gh2tg4 | an ancient posttranslational modification Polyglutamylation: a fine- regulator of protein function?' |
| cord-288673-ku3tmjd3 | 3C- like protease inhibitors Regulation of bacterial protease activity Proteins with antifungal properties and other medicinal applications from plants and mushrooms Adaptation of Helicoverpa armigera( Lepidoptera: Noctuidae) to a proteinase inhibitor expressed in transgenic tobacco Novel inhibitor for prolyl tripeptidyl aminopeptidase from Porphyromonas gingivalis and details of substrate- recognition mechanism Major surface protease of trypanosomatids: one size fits all? |
| cord-288673-ku3tmjd3 | are new control methods required? |
| cord-288673-ku3tmjd3 | cathepsin B An epoxysuccinic acid derivative(loxistatin)-induced hepatic injury in rats and hamsters Affinity chromatography: principles and methods Computational perspectives into plasmepsins structure- function relationship: implications to inhibitors design IA3, an aspartic proteinase inhibitor from Saccharomyces cerevisiae, is intrinsically unstructured in solution Host cathepsin D response to tumor in the normal and pepstatin- treated mouse Isolation and characterization of E-64, a new thiol protease inhibitor Protein proteinase inhibitor genes in combat against insects, pests, and pathogens: natural and engineered phytoprotection Protease inhibitors: a panacea? |
| cord-288673-ku3tmjd3 | thuringiensis( Bt) transgenic crop: an environment friendly insect- pest management strategy Virulence strategies of plant pathogenic bacteria Understanding the mechanism of action of the exfoliative toxins of Staphylococcus aureus Antiprotease therapy in cancer: hot or not? |
| cord-321441-t1v0pu0w | Why do RNA viruses recombine? |
| cord-291210-ghjseynl | An immediate question then arises: What affect does the unusual structure of SCoV E protein transmembrane domain have upon the lipid bilayer? |
| cord-291210-ghjseynl | Do more complex organisms have a greater proportion of membrane proteins in their genomes? |
| cord-291210-ghjseynl | What might the hairpin structure of SCoV E protein look like? |
| cord-291210-ghjseynl | With a structural model of SCoV E protein at hand, is it possible to rationalize the effects of the protein upon the lipid bilayer? |
| cord-321762-7kiahjyy | What appears to be lost in the process is the target: How useful are these representations to the practicing biologist? |
| cord-291727-4wfhuvww | How is dual coding regulated? |
| cord-291727-4wfhuvww | In which cellular processes should we expect to see a high abundance of frameshifted proteins? |
| cord-291727-4wfhuvww | What is the identity of all dual- coding genes and out- of- frame proteins in the genome? |
| cord-291727-4wfhuvww | What is the sequence or structural motif for dual coding? |
| cord-306111-wn1gxhk9 | A longitudinal study Reconstitution of opsonizing activity by infusion of mannan- binding lectin( MBL) to MBL- deficient humans Human plasma- derived mannose- binding lectin: a phase I safety and pharmacokinetic study An assay for the mannan- binding lectin pathway of complement activation Functional analysis of the classical, alternative, and MBL pathways of the complement system: standardization and validation of a simple ELISA Inherited deficiency of mannan- binding lectin- associated serine protease 2 Deficiency of the mannan- binding lectin pathway of complement and poor outcome in cystic fibrosis: bacterial colonization may be decisive for a relationship L- ficolin in children with recurrent respiratory infections Mannan- binding lectin insufficiency in children with recurrent infections of the respiratory system Human mannose- binding lectin in immunity: friend, foe, or both? |
| cord-306111-wn1gxhk9 | AIDS Human mannose- binding protein gene is regulated by interleukins, dexamethasone and heat shock Modulatory effect of mannose- binding lectin on cytokine responses: possible roles in HIV infection Low mannose- binding lectin serum concentrations in HIV long- term nonprogressors? |
| cord-306111-wn1gxhk9 | Mannan- binding lectin enhances susceptibility to visceral leishmaniasis Dual role of mannan- binding protein in infections: another case of heterosis? |
| cord-016442-3su3x6ed | How may a protein transition spread across the world( e.g. which countries are best suited for introducing and testing NPFs)? |
| cord-016442-3su3x6ed | In addition to technological issues, questions should be addressed such as: Cooperation with what other parties is useful( e.g. for optimal use of the crop)? |
| cord-016442-3su3x6ed | This puts forward three major challenges: how to obtain a wide range of textures by using plant proteins, how these textures are affected by ingredients other than proteins and how to obtain the desired flavour? |
| cord-016442-3su3x6ed | Those industrial policymakers who want to be among the first movers on the NPF market may start thinking about questions such as: Which markets are the most interesting options, specialty or bulk, which products and how to position the products on the market? |
| cord-016442-3su3x6ed | What are the preferences of the different consumer groups and which ones can be translated to product characteristics? |
| cord-016442-3su3x6ed | What chains should be developed and optimised, and with whom? |
| cord-016442-3su3x6ed | What may be the side effects of a protein transition( e.g. with respect to the North- South divide)? |
| cord-016442-3su3x6ed | What techniques are required to produce the desired products? |
| cord-016442-3su3x6ed | What trends in other areas( transport, technologies, lifestyles) may be relevant? |
| cord-016442-3su3x6ed | Which proteins or, even more basic, which crops seem feasible where? |
| cord-016442-3su3x6ed | key: cord-016442- 3su3x6ed authors: Aiking, Harry; de Boer, Joop; Vereijken, Johan M. title: Transition Feasibility and Implications for Stakeholders date: 2006 journal: Sustainable Protein Production and Consumption: Pigs or Peas? |
| cord-319658-u0wjgw50 | Cellular hijacking: a common strategy for microbial infection Diet, microbiota and autoimmune diseases Integration of Innate Immune Signaling Self or non- self? |
| cord-316273-vo6j8zb0 | In vivo evolution of HIV-1 co- receptor usage and sensitivity to chemokine- mediated suppression Inhibition of VSV binding and infectivity by phosphatidylserine: is phosphatidylserine a VSV- binding site? |
| cord-316273-vo6j8zb0 | the Ebola virus glycoprotein Conserved structural features in the interaction between retroviral surface and transmembrane glycoproteins? |
| cord-326015-ky4y2xjt | Do other Golgi resident proteins display similar signals? |
| cord-313694-p2sgaypq | Decreased transfer of oligosaccharide from oligosaccharideqipid to protein acceptors in regenerating rat liver Stimulation of lipid- linked oligosaccharide assembly duing oviduct differentiation Cell- type- related segregation of surface galactosyl- containing components at an early developmental stage in hemopoietic bone marrow cells in the rabbit Changes in asparagine- linked sugar chains of human promyelocytic leukemic cells( HL-60) during monocytoid differentiation and myeloid differentiation Are glycoproteins and glycosaminoglycans components of the eukaryotic genome? |
| cord-313694-p2sgaypq | The accesibility to trypsin of the susceptible bonds in ovine submaxillary land mucoproteins Influenza C virus uses 9- 0-Acetyl- N- Acetylneuraminic Acid as a high affinity receptor determinant for attachment to cells Carbohydrate- binding sites of the mannose- specific fimbrial lectins of enterobacteria The mouse egg's receptor for sperm; What is it and how does it work? |
| cord-006230-xta38e7j | 2´-deoxy- cAMP in human cell lines: Another second messenger? |
| cord-006230-xta38e7j | > Ser Extra- adrenal glucocorticoid synthesis in the intestinal epithelium: more than a drop in the ocean? |
| cord-006230-xta38e7j | Converging of the classical mitochondria- related pathway in Parkinson and nuclear DNA- repair signaling? |
| cord-006230-xta38e7j | Detoxification by conjugation of glutathione? |
| cord-006230-xta38e7j | Is formaldehyde a good example for a"genotoxic carcinogen"with a threshold mode of action? |
| cord-006230-xta38e7j | The transcriptome analyses of human cells showed that additionally to the 30.000 protein coding sequences the human DNA codes for much more( 450.000?) |
| cord-006230-xta38e7j | possible link between diabetes and cancer? |
| cord-306904-8iteddug | Properties of the decarboxylated gamma- carboxyglutamic acid protein from calf bone Coordinated transcriptional regulation of Hspa1a gene by multiple transcription factors: crucial roles for HSF-1 Plasma levels of Hsp70 and anti- Hsp70 antibody predict risk of acute coronary syndrome Heat shock protein 70 kDa: molecular biology, biochemistry, and physiology Heat shock proteins in breast cancer progression- a suitable case for treatment? |
| cord-306904-8iteddug | Reconstituted human myosin light chain phosphatase reveals distinct roles of two inhibitory phosphorylation sites of the regulatory subunit, MYPT1 Structural and functional analysis of the GerD spore germination protein of Bacillus species Spores of Bacillus subtilis: their resistance to and killing by radiation, heat and chemicals Germination of spores of Bacillales and Clostridiales species: mechanisms and proteins involved Spore germination How do spores germinate? |
| cord-306904-8iteddug | The deletion of exon 3 in the cardiac ryanodine receptor is rescued by beta strand switching ATPinduced dimerization of the FF epsilon subunit from Bacillus PS3: a hydrogen exchange- mass spectrometry study Crystal structure of the epsilon subunit of the proton- translocating ATP synthase from Escherichia coli Phosphorylation of the cyclin CaPcl5 modulates both cyclin stability and specific recognition of the substrate Principles of CDK regulation Cyclin specificity: how many wheels do you need on a unicycle? |
| cord-332344-upsn0zb4 | An insight into iTRAQ: where do we stand now? |
| cord-268326-sbz3uk5h | D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus Does intraneuronal accumulation of carboxyl terminal fragments of the amyloid precursor protein trigger early neurotoxicity in Alzheimer's disease? |
| cord-268326-sbz3uk5h | Elastinolytic activity in granules of human polymorphonuclear leukocytes Defensins- and cathepsin G- ANCA in systemic lupus erythematosus T cell hyperactivity in lupus as a consequence of hyperstimulatory antigen- presenting cells Steroids, lyosomes and systemic lupus erythematosus Autoimmunity to lysosomal enzymes: new clues to vasculitis and glomerulonephritis? |
| cord-268326-sbz3uk5h | Enzyme replacement for lysosomal diseases Enzyme replacement therapy: lessons learned and emerging questions Enzyme replacement therapies: what is the best option? |
| cord-268326-sbz3uk5h | How close are we to therapies for Sanfilippo disease? |
| cord-268326-sbz3uk5h | from theory to therapy Autophagy: a lysosomal degradation pathway with a central role in health and disease Endo- lysosomal and autophagic dysfunction: a driving factor in Alzheimer's disease? |
| cord-268326-sbz3uk5h | recent patents and future strategies Tuning protein folding in lysosomal storage diseases: the chemistry behind pharmacological chaperones Treatment strategies for lysosomal storage disorders Cysteine proteases as therapeutic targets: does selectivity matter? |
| cord-314567-purplsjn | How Parkinson's disease meets nucleolar stress NF90 isoforms, a new family of cellular proteins involved in viral replication? |
| cord-314567-purplsjn | The nucleolus- a gateway to viral infection? |
| cord-333262-xvfl7ycj | ( G?) means an optional glycine insertion. |
| cord-330715-olypwdoq | spike glycoprotein Cryo- EM analysis of a feline coronavirus spike protein reveals a unique structure and camouflaging glycans Virus glycosylation: role in virulence and immune interactions Emergence of novel coronavirus and COVID-19: whether to stay or die out? |
| cord-320015-lbr2q4qh | Characterization of primary and memory CD8 T- cell responses against ranavirus( FV3) in Xenopus laevis Xenopus laevis: A possible vector of Ranavirus infection? |
| cord-320015-lbr2q4qh | a purine nucleoside phosphorylase Genomic sequence of a ranavirus( family Iridoviridae) associated with salamander mortalities in North America Poxviruses: past, present, and future How similar are poxviruses? |
| cord-327199-ggomuomb | HECT ubiquitin ligases link viral and cellular PPXY motifs to the vacuolar protein- sorting pathway Visualization of intracellular transport of vesicular stomatitis virus nucleocapsids in living cells Mechanisms for enveloped virus budding: can some viruses do without an ESCRT? |
| cord-014462-11ggaqf1 | Both ATP and GTP were utilized as phosporyl donors and Mn 2? |
| cord-014462-11ggaqf1 | Cut off was calculated as Mean negative control? |
| cord-014462-11ggaqf1 | FMDV P1- 3CD''O''vaccine gene constructs in pCDNA3.1? entrapped by the nanoparticles was prepared by using different molarity of calcium chloride and disodium hydrogen orthophosphate. |
| cord-014462-11ggaqf1 | Helicase activity of NSs was absolutely dependent on ATP and Mg 2? |
| cord-014462-11ggaqf1 | How do Indian journals perform in Maintaining quality? |
| cord-014462-11ggaqf1 | How do motivate the scientists to improve their scientific output? |
| cord-014462-11ggaqf1 | How to motivate the scientists to improve their scientific output? |
| cord-014462-11ggaqf1 | In this regard, rNSs is a unique enzyme which does not have the canonical helicase motifs but can catalyze dsDNA/ dsRNA unwinding in an ATP and Mg 2? |
| cord-014462-11ggaqf1 | Should we compare the growth of Indian science with other developed countries? |
| cord-014462-11ggaqf1 | What ails Indian Science? |
| cord-014462-11ggaqf1 | What criteria should be adopted to judge the quality and standard of scientific research? |
| cord-318551-c1qr27lg | The nucleolus- a gateway to viral infection? |
| cord-318551-c1qr27lg | What then might be the most appropriate strategy to unambiguously distinguish between factors involved in replication and/or transcription but not in translation, between( À) and( þ) strand RNA synthesis, and between those directly involved in a given mechanism and those that affect this mechanism indirectly? |
| cord-319884-d8n0aokl | Is SELDI- TOF a valid tool for diagnostic biomarkers? |
| cord-319884-d8n0aokl | Why 3-D? |
| cord-330337-d41imvo7 | it matter? |
| cord-023143-fcno330z | *? |
| cord-023143-fcno330z | , Cara Wilsont, Kelledy Mansons, Michael Wyands, Bruce Walker?, Ronald C. Desrosiers |
| cord-023143-fcno330z | However, productive virus replication is minimized by antiviral CD8 T cells which suppress( kill?) |
| cord-023143-fcno330z | PrP genes were used to demonstrate that the"specie9 bank?' |
| cord-023143-fcno330z | The interferons( IFNs) a n? a family of cytokines whose functions include the protection of cells against viral infection. |
| cord-023143-fcno330z | Thes? |
| cord-023143-fcno330z | ofthe influenza HA protein from this second promoter in baby hamster kidney( BHK) cells was approximately 50?? |
| cord-023143-fcno330z | ofthe influenza HA protein from this second promoter in baby hamster kidney( BHK) cells was approximately 50?? |
| cord-319754-5isw53wl | An Essential"Receptor"or an"Accessory Attachment Factor"for Hepatitis A Virus? PIP5K- driven PtdIns(4,5)P2 synthesis: Regulation and cellular functions Function and dysfunction of the PI system in membrane trafficking PIP2: Choreographer of actin- adaptor proteins in the HIV-1 dance Synchronized HIV assembly by tunable PIP2 changes reveals PIP2 requirement for stable Gag anchoring Quantification of phosphoinositides reveals strong enrichment of PIP2 in HIV-1 compared to producer cell membranes Investigation of the Lipid Binding Properties of the Marburg Virus Matrix Protein VP40 Type I phosphatidylinositol-4-phosphate |
| cord-319754-5isw53wl | Signaling Multifaceted roles for lipids in viral infection Ultrastructure of the replication sites of positive- strand RNA viruses Does form meet function in the coronavirus replicative organelle? |
| cord-006229-7yoilsho | But what would happen if the HFD was switched to normal pellet diet in these diabetic rats? |
| cord-006229-7yoilsho | Core or coating material? |
| cord-006229-7yoilsho | Increased GABA release in human neocortex at high intracellular sodium and low extracellular calcium-an anti- seizure mechanism?] |
| cord-006229-7yoilsho | Occasionally there are specific questions occurring on the ruminant xenobiotic metabolism: 1) are the observed metabolites ruminant specific and formed directly in the rumen? 2) are ruminants able to cleave plant specific metabolites like glycosides to the respective aglycon? |
| cord-006229-7yoilsho | Occasionally there are specific questions occurring on the ruminant xenobiotic metabolism: 1) are the observed metabolites ruminant specific and formed directly in the rumen? 2) are ruminants able to cleave plant specific metabolites like glycosides to the respective aglycon? |
| cord-006229-7yoilsho | The data point to a role of Rac1-regulated filamentous( nuclear?) |
| cord-006229-7yoilsho | The γH2AX Assay for Genotoxic and Nongenotoxic Agents: Comparison of H2AX Phosphorylation with Cell Death Response Perturbation of mitosis through inhibition of histone acetyltransferases: the key to ochratoxin a toxicity and carcinogenicity? |
| cord-006229-7yoilsho | Vitamin D metabolism-Involved in triazole fungicide toxicity? |
| cord-006229-7yoilsho | What dictates the uptake and translocation of nanoparticles in vitro? |
| cord-006229-7yoilsho | What would happen without this exception? |
| cord-307731-a2fqmaly | 2020, 8, 246 Single- molecule pulling simulations can discern active from inactive enzyme inhibitors The light and dark sides of virtual screening: What is there to know? |
| cord-307731-a2fqmaly | An endless staircase? |
| cord-307731-a2fqmaly | How do small molecule aggregates inhibit enzyme activity? |
| cord-304343-m7tbdfri | FIP200, a counterpart of yeast Atg17? |
| cord-304343-m7tbdfri | Lipid starvation or indigestion? |
| cord-304343-m7tbdfri | Quantitative proteomics identifies ncoa4 as the cargo receptor mediating ferritinophagy Role of autophagy in a model of obesity: A long- term high fat diet induces cardiac dysfunction Is autophagy associated with diabetes mellitus and its complications? |
| cord-304343-m7tbdfri | What do we really know in vivo? |
| cord-327744-5k8np850 | Do antisense proteins exist? |
| cord-321013-8pkrg0mx | A clinically important virus? |
| cord-321013-8pkrg0mx | If indeed so, could this then indicate a probable basis for the increased pathogenicity of SARS- CoV compared to HCoV- NL63? |
| cord-330668-7aw17jf8 | A stabilized by intermolecular hydrogen bonding Tilt angle of a trans- membrane helix is determined by hydrophobic mismatch Structure, topology, and tilt of cell- signaling peptides containing nuclear localization sequences in membrane bilayers determined by solid- state NMR and molecular dynamics simulation studies Snorkeling of lysine side chains in transmembrane helices: how easy can it get? |
| cord-325230-3kg4oe4g | another mechanism for host protein synthesis shutoff? |
| cord-338980-pygykil7 | With inserts and changing structural dynamics between clades or viruses, the questions become 1) which sequence motif are displayed and 2) to what extent are these sequence motifs displayed? |
| cord-290472-w77cmljm | Autoallergy: a pathogenetic factor in atopic dermatitis? |
| cord-290472-w77cmljm | Is it possible that diseases such as multiple sclerosis and asthma actually are caused by the coordinating effect of genetic susceptibility and, say, viral infection? |
| cord-290472-w77cmljm | The evolving role of mass spectrometry in cancer biomarker discovery RNA- Seq: a revolutionary tool for transcriptomics Comparative proteomics approach to screening of potential diagnostic and therapeutic targets for oral squamous cell carcinoma Asthma genetics: personalizing medicine Large- scale analysis of the yeast proteome by multidimensional protein identification technology Overcoming the dynamic range problem in mass spectrometry- based shotgun proteomics Autoantibodies as potential biomarkers for breast cancer Global analysis of protein activities using proteome chips Severe acute respiratory syndrome diagnostics using a coronavirus protein microarray ProCAT: a data analysis approach for protein microarrays Asthma and autoimmunity: is there a connection? |
| cord-290472-w77cmljm | Will we find that a disease associated with certain genetic markers also develops specific autoantibodies? |
| cord-290472-w77cmljm | mRNA? |
| cord-303555-mwu72q7w | A Crucial Role in the Action of Insulin, EGF, and pp60src? |
| cord-303555-mwu72q7w | The MEK Kinases MEKK4/ Ssk2p Facilitate Complexity in the Stress Signaling Responses of Diverse Systems Upstream Regulators of the c- Jun Amino- Terminal Kinases? |
| cord-303555-mwu72q7w | The first question the academic investigator should ask is, in their hands, does the dose- response effect on tumor cell growth/ viability correspond to the claimed inhibitory IC50 of the compound against its purified specific target? |
| cord-303555-mwu72q7w | The first thing the independent academic collaborator needs to know is what was the highest safe dose of the compounds used in prior mouse studies? |
| cord-322955-7dw32xby | Evaluation of COVID-19 RT- qPCR test in multi- sample pools Role of Chest CT in Diagnosis and Management COVID-19)? |
| cord-333089-ufyzqgqk | Circulating plasma concentrations of angiotensin- converting enzyme 2 in men and women with heart failure and effects of renin- angiotensin- aldosterone inhibitors Predictors of mortality in hospitalized COVID-19 patients: a systematic review and meta- analysis Impact of sex and gender on COVID-19 outcomes in Europe Are sex discordant outcomes in COVID-19 related to sex hormones? |
| cord-334592-54dofkxh | This study provided the first evidence that the autophagy machinery can deliver endogenously synthesized antigens for presentation on MHC class II molecules to CD4+ T cells Antigen processing via autophagy- not only for MHC class II presentation anymore? |
| cord-328003-yovp8squ | What Are the Most Powerful Immunogen Design Vaccine Strategies? |
| cord-328003-yovp8squ | What Are the Most Powerful Immunogen Design Vaccine Strategies? |
| cord-339558-li65qvq9 | The presented review aims at confronting the question: ‘ how proteomics can help in tackling SARS- CoV-2? ’ |
| cord-332784-xkc89uaz | A review on the cleavage priming of the spike protein on coronavirus by angiotensin- converting enzyme-2 and furin How far can virtual screening take us in drug discovery? |
| cord-352371-t54zftal | The DEF data base of sequence based protein fold class predictions How many nuclear hormone receptors are there in the human genome? |
| cord-312741-0au4nctt | A decade after SARS: strategies for controlling emerging coronaviruses SARS vaccines: where are we? |
| cord-312741-0au4nctt | In vitro inhibition of severe acute respiratory syndrome coronavirus by chloroquine Inhibition of human coronavirus 229E infection in human epithelial lung cells( L132) by chloroquine: involvement of p38 MAPK and ERK A systematic screen of FDA- approved drugs for inhibitors of biological threat agents Effects of chloroquine on viral infections: an old drug against today's diseases? |
| cord-312741-0au4nctt | The mercurial nature of neutrophils: still an enigma in ARDS? |
| cord-312741-0au4nctt | the beginning of another SARS- like pandemic? |
| cord-335310-61wibso4 | vaccines A sensitive in vivo model for quantifying interstitial convective transport of injected macromolecules and nanoparticles Follicular dendritic cells: dynamic antigen libraries What role does the route of immunization play in the generation of protective immunity against mucosal pathogens? |
| cord-338468-c0jv3i1t | The trinity of COVID-19: Immunity, inflammation and intervention On the molecular determinants of the SARS- CoV-2 attack Are the universes of antibodies and antigens symmetrical? |
| cord-343791-0vykwml5 | With several self- assembling platforms being discovered and developed over the past 50 years, it is worth considering the cross- roads that lay ahead: should we focus on the development of the promising platforms discussed here, or should we continue searching for new, novel platforms? |
| cord-329625-hx2rsi91 | The multifunctional nucleolus Cell cycle dependent localisation of the coronavirus nucleocapsid protein Trafficking mechanism of West Nile( Sarafend) virus structural proteins Visualization of intracellular transport of vesicular stomatitis virus nucleocapsids in living cells Are nidoviruses hijacking the autophagy machinery? |
| cord-329625-hx2rsi91 | What is new in the nucleolus? |
| cord-329625-hx2rsi91 | the nucleolus-a gateway to viral infection? |
| cord-356019-k7gs1ohp | Pharming and transgenic plants Down- regulated expression of plant- specific glycoepitopes in alfalfa Plant- specific glycosylation patterns in the context of therapeutic protein production Is the drought over for pharming? |
| cord-332948-h297ukuu | Can We Rely on Computational Predictions To Correctly Identify Ligand Binding Sites on Novel Protein Drug Targets? |
| cord-332948-h297ukuu | r o o f resolution silico assessment of potential druggable pockets on the surface of?? |
| cord-332948-h297ukuu | r o o f resolution silico assessment of potential druggable pockets on the surface of?? |
| cord-277424-9aimvogs | ( Gadus morhua L.) Ontogeny-novel roles in tissue remodelling and mucosal immune defences? |
| cord-277424-9aimvogs | ( Gadus morhua L.)-a role in development and homeostasis? |
| cord-277424-9aimvogs | Desmoplakin is required for epidermal integrity and morphogenesis in the Xenopus laevis embryo Mechanisms of adiponectin action in fertility: an overview from gametogenesis to gestation in humans and animal models in normal and pathological conditions Shark novel antigen receptors- the next generation of biologic therapeutics? |
| cord-277424-9aimvogs | Does prolidase indicate worsening of hepatitis B infection? |
| cord-277424-9aimvogs | Peptidylarginine deiminases- roles in cancer and neurodegeneration and possible avenues for therapeutic intervention via modulation of exosome and microvesicle( EMV) release? |
| cord-277424-9aimvogs | The Hsp90 chaperone complex as a novel target for cancer therapy Influence of interleukin-8 and neutrophil extracellular trap( NET) formation in the tumor microenvironment: Is there a pathogenic role? |
| cord-277424-9aimvogs | The molecular chaperone Hsp90 plays a role in the assembly and maintenance of the 26S proteasome Interplay of host- pathogen microvesicles and their role in infectious disease Kinetic analysis of novel mono- and multivalent VHH- fragments and their application for molecular imaging of brain tumours Protein moonlighting: what is it, and why is it important? |
| cord-350935-p6euuop3 | A new coronavirus associated with human respiratory disease in China Liver diseases in COVID-19: Etiology, treatment and prognosis Controversial treatments: an updated understanding of the Coronavirus Disease Recent applications of deep learning and machine intelligence on in silico drug discovery: methods, tools and databases Enrichment or depletion of a GO category within a class of genes: which test? |
| cord-305143-mqd4ioj4 | Do they function in host interaction? |
| cord-305143-mqd4ioj4 | Do they possess as of yet undiscovered, but shared protein domains? |
| cord-305143-mqd4ioj4 | Do they result in altered pathology or clinical symptoms? |
| cord-305143-mqd4ioj4 | Our automated approach provides a starting point for the systematic computational and experimental study of these species- and strain- specific proteins- studies, which eventually will provide answers to such questions as: Are these species- and strain- specitic proteins essential under certain conditions? |
| cord-305143-mqd4ioj4 | Similarly, what would be the consequence of adding a Cterminal GlyL_C domain to the gL protein of VZV( which contains one Herpes_UL1 domain), and so making it similar to the gL protein found in HSV-1 and HSV-2( which has a Herpes_UL1--GlyL_C architecture)? |
| cord-305143-mqd4ioj4 | This raises the question-are such share named truly justified for proteins composed of unrelated domains? |
| cord-292688-w4zvfkyl | How does this signal- less type of cargo enter the CCVs allowing it to be removed? |
| cord-292688-w4zvfkyl | This raises a very intriguing set of questions: are there multiple classes of CCVs forming from the ISG all with a di¡erent cargo?, would these CCVs all have a di¡erent destination? |
| cord-292688-w4zvfkyl | This raises a very intriguing set of questions: are there multiple classes of CCVs forming from the ISG all with a di¡erent cargo?, would these CCVs all have a di¡erent destination? |
| cord-292688-w4zvfkyl | or is there a single species of CCVs forming with a mixed cargo? |
| cord-292688-w4zvfkyl | the membrane tra¤c police? |
| cord-292688-w4zvfkyl | would this CCV deliver its cargo to one destination, for example, the endosome, from where further sorting would occur? |
| cord-341129-eo0vjcmk | How general is cooperativity? |
| cord-341129-eo0vjcmk | What other classes of viral fusion proteins might there be? |
| cord-346314-o9fjpqaj | HIV-1 Tat fluctuations drive phenotypic diversity DEDD and DEDD2 associate with caspase-8/10 and signal cell death Chaperones and multitasking proteins in the nucleolus: networking together for survival? |
| cord-354950-kmpbdvof | : where are we? |
| cord-300418-s4wt5gim | Alternatively, prevention of TNF- dependent NF- κB activation by linear chains through the inhibition of one or more of the E2s( UBCH5, E2- 25kDa or UBCH7) may suppress NF- κB activity and inflammatory and immune responses-but again, with what long- term clinical price? |
| cord-300418-s4wt5gim | Does impairment of the ubiquitin- proteasome system or the autophagylysosome pathway predispose individuals to neurodegenerative disorders such as Parkinson's disease? |
| cord-300418-s4wt5gim | The UPS and autophagy in chronic neurodegenerative disease: six of one and half a dozen of the other-or not? |
| cord-300418-s4wt5gim | The human F box protein beta- Trcp associates with the Cul1/ Skp1 complex and regulates the stability of beta- catenin NEDD8 modification of cul-1 activates SCF(beta(TrCP)-dependent ubiquitination of IκBα IAPs: what's in a name? |
| cord-300418-s4wt5gim | The role of parkin in familial and sporadic Parkinson's disease Parkin and defective ubiquitination in Parkinson's disease Depletion of 26S proteasomes in mouse brain neurons causes neurodegeneration and Lewy- like inclusions resembling human pale bodies Is malfunction of the ubiquitin proteasome system the primary cause of alphasynucleinopathies and other chronic human neurodegenerative disease? |
| cord-300418-s4wt5gim | Therefore, ubiquitylation should be amenable to therapeutic intervention for inflammatory and immune disorders, but at what level? |
| cord-350286-n7ylgqfu | Do Viral Proteins Possess Unique Features? |
| cord-350286-n7ylgqfu | Intrinsic disorderedness and functionality of HIF-1α along with its interacting proteins Why are"natively unfolded"proteins unstructured under physiologic conditions? |
| cord-346965-0oq2n0af | Protein clefts in molecular recognition and function From protein structure to biochemical function? |
| cord-296347-fanlvxqs | Friend or foe in immunity to infection? |
| cord-296347-fanlvxqs | How, then, does mK3 access the luminal domain of HC molecules and trigger its ubiquitination? |
| cord-296347-fanlvxqs | I contains an invariant chain homologous sequence that binds to MHC class II molecules Gamma- secretase, Notch, Abeta and Alzheimer's disease: Where do the presenilins fit in? |
| cord-296347-fanlvxqs | I heavy chains involves a ubiquitin- conjugated intermediate PIAS proteins and transcriptional regulation- more than just SUMO E3 ligases? |
| cord-296347-fanlvxqs | Intracellular targeting of the proteasome A role for N- glycanase in the cytosolic turnover of glycoproteins Endoplasmic reticulum- associated protein degradation- one model fits all? |
| cord-296347-fanlvxqs | The substrate translocation channel of the proteasome Herp, a new ubiquitin- like membrane protein induced by endoplasmic reticulum stress Gamma- secretase: Proteasome of the membrane? |
| cord-348972-r94fhpe0 | The crispr spacer space is dominated by sequences from species- specific mobilomes Prophages and bacterial genomics: what have we learned so far? |
| cord-324667-wmhdw1qs | Genetics of keratoconus: where do we stand? |
| cord-324667-wmhdw1qs | the central India eye and medical study Does ethnic origin influence the incidence or severity of keratoconus? |
| cord-324667-wmhdw1qs | the interaction between the ocular surface and lacrimal glands Changes in tear protein profile in keratoconus disease Level of tear endothelin-1 and plasminogen in patients with glaucoma and proliferative diabetic retinopathy Keratoconus: an inflammatory disorder? |
| cord-262119-s6hc7fxs | 2019 Longitudinal analyses reveal immunological misfiring in severe COVID-19 Is a"Cytokine Storm"Relevant to COVID-19? |
| cord-262119-s6hc7fxs | : What do we know about children? |
| cord-262119-s6hc7fxs | : Why Children Fare Better than Adults? |
| cord-262119-s6hc7fxs | Antivirals? |
| cord-262119-s6hc7fxs | Apossible smart targeting of the autophagy pathway Open questions for harnessing autophagy- modulating drugs in the SARS- CoV-2 war: hope or hype? |
| cord-262119-s6hc7fxs | As Two Sides of the Same Coin: Friends or Foes? |
| cord-262119-s6hc7fxs | Compared to the Single X- Chromosome in Males? |
| cord-262119-s6hc7fxs | Pre- exposure prophylaxis? |
| cord-262119-s6hc7fxs | Vaccine? |
| cord-341378-pw60qx7c | Of the two viral membrane proteins, the smaller one, El, is necessary for formation of the envelope, and is restricted to internal cell membranes; apparent?; it only reaches the cell surface as part of the budded virion 12 • 3. |
| cord-341378-pw60qx7c | Which, if any, of these various features might be responsible for the protein's intracellular localization? |
| cord-336119-8g37xsys | An open- source molecular graphics tool New insights on the antiviral effects of chloroquine against coronavirus: What to expect for COVID-19? |
| cord-336119-8g37xsys | Exploring anti- rheumatic drugs to reduce immune hyperactivation in HIV/ AIDS Does zinc supplementation enhance the clinical efficacy of chloroquine/ hydroxychloroquine to win todays battle against COVID-19? |
| cord-329149-1giy1fow | A secreted protein microarray platform for extracellular protein interaction discovery Viral mimicry of cytokines, chemokines and their receptors Pathogen- derived immunomodulatory molecules: future immunotherapeutics? |
| cord-329149-1giy1fow | How do pathogens drive the evolution of paired receptors? |
| cord-329149-1giy1fow | How many drug targets are there? |
| cord-329149-1giy1fow | What have RNAi screens taught us about viral- host interactions? |
| cord-309384-vlk8cebh | Crystal structure of β- hexosaminidase B in complex with pyrimethamine, a potential pharmacological chaperone Induced secretion of β- hexosaminidase by human brain endothelial cells: a novel approach in Sandhoff disease? |
| cord-309384-vlk8cebh | Do mitochondria act as"cargo boats"in the journey of GD3 to the nucleus during apoptosis? |
| cord-309384-vlk8cebh | Galectin-1 is a major receptor for ganglioside GM1, a product of the growth- controlling activity of a cell surface ganglioside sialidase, on human neuroblastoma cells in culture Carbohydrate- to- carbohydrate interaction, through glycosynapse, as a basis of cell recognition and membrane organization Carbohydrate- Carbohydrate interaction in basic cell biology Carbohydrate- carbohydrate interactions in cell recognition Specific interaction between gangliotriaosylceramide( Gg3) and sialosyllactosylceramide( G(M3) as a basis for specific cellular recognition between lymphoma and melanoma cells Brain gangliosides in axon- myelin stability and axon regeneration Gangliosides and the multiscale modulation of membrane structure Receptor modifications in glycobiology Neural functions of glycolipids Lipid rafts: keys to neurodegeneration Regulation of human EGF receptor by lipids Gangliosides as components of lipid membrane domains Membrane organization and lipid rafts Revitalizing membrane rafts: new tools and insights Lipid rafts as a membraneorganizing principle Lipids and cholesterol as regulators of traffic in the endomembrane system Principles of microdomain formation in biological membranes- are there lipid liquid ordered domains in living cellular membranes? |
| cord-309384-vlk8cebh | MDR1 Pglycoprotein is a lipid translocase of broad specificity, while MDR3 P- glycoprotein specifically translocates phosphatidylcholine ABC lipid transporters: extruders, flippases, or flopless activators? |
| cord-309384-vlk8cebh | Pathogenic cascades in lysosomal diseasewhy so complex? |
| cord-309384-vlk8cebh | origin and function Nomenclature of glycolipids Neuronal dysfunction with aging and its amelioration Are globoseries glycosphingolipids SSEA-3 and-4 markers for stem cells derived from human umbilical cord blood? |
| cord-346916-jj4l9ydl | : what have we learned and where are we headed? |
| cord-346916-jj4l9ydl | Toll- like receptor 3 in viral pathogenesis: friend or foe? |
| cord-346819-11fkgzaa | Severe acute respiratory syndrome coronavirus sequence characteristics and evolutionary rate estimate from maximum likelihood analysis Prediction of protein stability changes for single- site mutations using support vector machines Comparative Protein Structure Modeling Using MODELLER Python: a programming language for software integration and development Systematic validation of protein force fields against experimental data Are Protein Force Fields Getting Better? |
| cord-346819-11fkgzaa | The establishment of reference sequence for SARS- CoV-2 and variation analysis Characterization of the receptor- binding domain( RBD) of 2019 novel coronavirus: implication for development of RBD protein as a viral attachment inhibitor and vaccine The spike protein of SARS- CoV- a target for vaccine and therapeutic development Angiotensin- converting enzyme 2: a functional receptor for SARS coronavirus Can one predict protein stability? |
| cord-346819-11fkgzaa | Why are RNA virus mutation rates so damn high? |
| cord-333309-21czobqy | Another E3 ligase( E3?) |
| cord-333309-21czobqy | Early events during BK virus entry and disassembly The ER translocon and retrotranslocation: is the shift into reverse manual or automatic? |
| cord-333309-21czobqy | I molecules determine their susceptibility to human cytomegalovirus US11-mediated down- regulation Interactions among the major and minor coat proteins of polyomavirus ADAMs and protein disulfide isomerase: the key to regulated cell- surface protein ectodomain shedding? |
| cord-333309-21czobqy | a"molecular gearbox"in the ubiquitin pathway? |
| cord-329448-kxxy60x9 | A morphological study of the coated vesicle isolated from the nerve endings of the guinea pig brain, with special reference to the mechanism of membrane movements Cargo regulates clathrincoated pit dynamics Clathrin- dependent mechanisms of G protein- coupled receptor endocytosis Clathrin- coated pits: vive la difference? |
| cord-329448-kxxy60x9 | The BAR- domain family of proteins: a case of bending and binding? |
| cord-329448-kxxy60x9 | Tubular membrane invaginations coated by dynamin rings are induced by GTP- gamma S in nerve terminals Tandem arrangement of the clathrin and AP-2 binding domains in amphiphysin 1 and disruption of clathrin coat function by amphiphysin fragments comprising these sites Regulatory mechanisms of dynamin- dependent endocytosis Dynamin: switch or pinchase? |
| cord-329448-kxxy60x9 | a raft- mediated mechanism for endocytosis and morphology of caveolae? |
| cord-337158-0iw2kcaf | In Pre- Processing? |
| cord-337158-0iw2kcaf | In- Column ATR- FTIR Spectroscopy to Monitor Affinity Chromatography Purification of Monoclonal Antibodies Overlapping Effects of New Monoclonal Antibodies for Severe Asthma Monoclonal Antibodies in Cancer Therapy Insight into Heterogeneous Distribution of Protein Aggregates at the Surface Layer Using Attenuated Total Reflection- Fourier Transform Infrared Spectroscopic Imaging Structural Determination of Protein- Based Polymer Blends With a Promising Tool: Combination of FTIR and STXM Spectroscopic Imaging Infrared Spectroscopy for Biopharmaceutical Protein Analysis Antibodies for the Treatment of Brain Metastases, a Dream or a Reality? |
| cord-337158-0iw2kcaf | Rituximab as a Case Study How To Measure and Analyze Tryptophan Fluorescence in Membranes Properly, and Why Bother? |
| cord-022262-ck2lhojz | But what about receptor specificity of these viruses? |
| cord-022262-ck2lhojz | Do these considerations allow us to safely conclude that, after its global eradication, poliovirus will have no chance to re- emerge through enterovirus evolution? |
| cord-022262-ck2lhojz | Does the history of the polyprotein determine how picornaviruses may evolve in the future? |
| cord-022262-ck2lhojz | For example, the precursor 3CD pr~ can be cleaved into 3C pr~ and 3CD p~ by a( cis?) cleavage in which the 3C/3CD pr~ proteinase is involved. |
| cord-022262-ck2lhojz | Genetic analyses have indicated that template switching occurs( predominantly?) |
| cord-022262-ck2lhojz | How do the multiple mechanisms alluded to interlace to produce a specific picornavirus disease syndrome? |
| cord-022262-ck2lhojz | How it is Likely to Evolve in the Future? |
| cord-022262-ck2lhojz | Moreover, if the genome has to be translated for replication to occur, how can inhibition of translation promote RNA synthesis? |
| cord-022262-ck2lhojz | The mechanism of RNA recombination in poliovirus Primary structure, gene organization and polypeptide expression of poliovirus RNA The poliovirus receptor protein is produced both as membrane- bound and secreted forms Transgenic mice susceptible to poliovirus Q[3 replicase as repressor of Q[3 RNA- directed protein synthesis Evolution of RNA genomes: does the high mutation rate necessitate high rate of evolution of viral proteins? |
| cord-022262-ck2lhojz | We have discussed different aspects relevant to picornavirus evolution, but we did not address one crucial question: Are picornaviruses a successful family? |
| cord-022262-ck2lhojz | What are the mechanisms by which the picornaviruses and other RNA virus families have diversified? |
| cord-022262-ck2lhojz | What is the identity of picornaviruses? |
| cord-022262-ck2lhojz | What is the mechanism by which poliovirus may eliminate foreign sequences? |
| cord-341701-zropd3mo | An interactive web- based dashboard to track COVID-19 in real time How will country- based mitigation measures influence the course of the COVID-19 epidemic? |
| cord-341701-zropd3mo | Can MALDI- TOF mass spectrometry reasonably type bacteria? |
| cord-341701-zropd3mo | Database allows unpublished, preliminary or proprietary data( e.g., antibody, MS, cell biology and genetic studies CHESS: a new human gene catalog curated from thousands of large- scale RNA sequencing experiments reveals extensive transcriptional noise Dynamic visualization of multi- level molecular data: the Director package in R Can we predict protein from mRNA levels? |
| cord-341701-zropd3mo | The human protein atlas: a spatial map of the human proteome Multiproteases combined with high- pH reverse- phase separation strategy verified fourteen missing proteins in human testis tissue Open- pFind enhances the identification of missing proteins from human testis tissue Proteoform: a single term describing protein complexity How many human proteoforms are there? |
| cord-342634-4ouhdjsr | But how is the opening of tertiary structure elements accomplished without the hydrolysis of ATP? |
| cord-342634-4ouhdjsr | How common are extraribosomal functions of ribosomal proteins? |
| cord-342634-4ouhdjsr | The prion protein has RNA binding and chaperoning properties characteristic of nucleocapsid protein NCP7 of HIV-1 Scavenger, transducer, RNA chaperone? |
| cord-342634-4ouhdjsr | What Are RNA Chaperones and Proteins with RNA Chaperone Activity? |
| cord-008777-i2reanan | ( 2) Is adhesion between leukocytes and endothelial cells affected by VCAM-1-specific siRNA? |
| cord-008777-i2reanan | (??). |
| cord-008777-i2reanan | (??). |
| cord-008777-i2reanan | A recent EcoNexus report underlined the potential for the process of plant transformation to result in genetic damage to the transformed plant( Genome Scrambling- Myth or Reality? |
| cord-008777-i2reanan | Arabidopsis thaliana- Distinct function in gene transcription dynamics? |
| cord-008777-i2reanan | Are they being adsorbed to the core cellulose chain or partly solubilized to a hydrolysis broth?" |
| cord-008777-i2reanan | Extending life by alternative respiration? |
| cord-008777-i2reanan | For example, one of the often asked questions is:"What is happening with shorter cellooligosacharides( DP 7 and up) laying on the surface of cellulose chain? |
| cord-008777-i2reanan | In order to further substantiate the potential use of siRNA for therapeutic purposes, we have set out to investigate two things:( 1) Does VCAM-1-specific siRNA affect the amount of VCAM-1 on the surface of HUVEC? |
| cord-008777-i2reanan | Is this realistic? |
| cord-008777-i2reanan | Two days of open discussions were organized in the context of the Austrian Genome Research Program GEN- AU( 3): topics were"Gene Diagnosis"( 2002) and"Genome Research- what is in it for me?"( 2004). |
| cord-008777-i2reanan | Will we switch from a petrochemical industry to a biobased chemistry within the next years? |
| cord-347710-ff64y6ef | : where do we stand? |
| cord-347710-ff64y6ef | Hsp90 inhibitors: a potential treatment for latent EBV infection? |
| cord-347710-ff64y6ef | The hepatitis E virus open reading frame 3 product interacts with microtubules and interferes with their dynamics The ins and outs of tubulin acetylation: more than just a post- translational modification? |
| cord-347710-ff64y6ef | diagnostic, prognostic, predictive, and treatment implications Altered states: selectively drugging the Hsp90 cancer chaperone Heat shock proteins promote cancer: it's a protection racket Heat shock proteins and cancer: intracellular chaperones or extracellular signalling ligands? |
| cord-320713-b37c8aye | How do microRNAs regulate gene expression? |
| cord-320713-b37c8aye | How does influenza virus regulate gene expression at the level of mRNA translation? |
| cord-320713-b37c8aye | What determines whether mammalian ribosomes resume scanning after translation of a short upstream open reading frame? |
| cord-320713-b37c8aye | another mechanism for host protein synthesis shutoff? |
| cord-320713-b37c8aye | is the eIF4E cap- binding factor required for viral mRNA translation? |
| cord-320713-b37c8aye | mRNAs Does phosphorylation of the cap- binding protein eIF4E play a role in translation initiation? |
| cord-323331-80d01l6f | A cause or a consequence? |
| cord-323331-80d01l6f | ARA160 is a BC- box- containing protein that mediates the degradation of Stat3 Onco- Golgi: is fragmentation a gate to cancer progression? |
| cord-323331-80d01l6f | Caspase- resistant Golgin-160 disrupts apoptosis induced by secretory pathway stress and ligation of death receptors Golgi disassembly in apoptosis: cause or effect? |
| cord-323331-80d01l6f | For example, is there an unfolded protein response( UPR)-like mechanism at the Golgi to cope with different stresses? |
| cord-323331-80d01l6f | How do the signaling pathways on the Golgi sense and transduce stress signals? |
| cord-323331-80d01l6f | Is there a common stress sensor on the Golgi? |
| cord-354030-8tfg881h | ( http://unafold.rna.albany.edu/? |
| cord-354030-8tfg881h | Immunoinformatics approach The use of databases, data mining, and immunoinformatics in vaccinology: where are we? |
| cord-354030-8tfg881h | The restriction enzyme cutting sites of Xho? |
| cord-354030-8tfg881h | and BamH? were then appended to the N and C terminals, respectively. |
| cord-334511-lx9608vy | : Is It Really$ 802 Million? |
| cord-334511-lx9608vy | How Much NMR Data Is Required to Determine a Protein- Ligand Complex Structure? |
| cord-334511-lx9608vy | Recent developments and new frontiers for targeting multi- protein complexes Screening protein- Single stranded RNA complexes by NMR spectroscopy for structure determination Intramolecularly stapled amphipathic peptides via a boron- sugar interaction Structure determination using solution NMR: Is it worth the effort? |
| cord-334511-lx9608vy | What Is the Question? |
| cord-334511-lx9608vy | Why not? |
| cord-352481-iq3wor3w | = 0.5? |
| cord-352481-iq3wor3w | A meta- server for the quality assessment of protein models Evaluating the absolute quality of a single protein model using structural features and support vector machines Improved protein structure prediction using potentials from deep learning Statistical potentials extracted from protein structures: Are these meaningful potentials? |
| cord-352481-iq3wor3w | How Accurate Are They? |
| cord-352481-iq3wor3w | What is the best reference state for designing statistical atomic potentials in protein structure prediction? |
| cord-276456-oa6hh7ky | How can studies on membrane fission contribute to our understanding of membrane fusion? |
| cord-276456-oa6hh7ky | How does fusion peptide insertion lead to fusion of viruses to cell membranes? |
| cord-276456-oa6hh7ky | How does synaptotagmin trigger neurotransmitter release? |
| cord-276456-oa6hh7ky | Is the interior of the fusion pore protein or lipid? |
| cord-276456-oa6hh7ky | Is this effect specific for calcium over magnesium? |
| cord-276456-oa6hh7ky | Membrane Fusion? |
| cord-276456-oa6hh7ky | What exactly are SNARE proteins doing? |
| cord-276456-oa6hh7ky | What is the role of calcium once it enters? |
| cord-276456-oa6hh7ky | What role does the TMD play? |
| cord-276456-oa6hh7ky | Why Is PtdIns-4,5-P 2 Needed for Exocytotic Fusion? |
| cord-276456-oa6hh7ky | Why is PIP(2) needed for exocytosis? |
| cord-276456-oa6hh7ky | Why is synaptic release so fast? |
| cord-337825-ujq9mxk7 | Does this peptide loop impact on the entry pathway type of SARS- CoV-2, compared to other known betacoronavirus lineage B? |
| cord-337825-ujq9mxk7 | Is it possible that it invades host cells via additional novel routes, not limited to ACE2? |
| cord-337825-ujq9mxk7 | Is there an S- like protein involved in invasion? |
| cord-337825-ujq9mxk7 | The SARS, MERS and novel coronavirus( COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? |
| cord-337825-ujq9mxk7 | Therefore, which are exactly the cell types that SARS- CoV-2 may attack? |
| cord-337825-ujq9mxk7 | the global RNA virome Classify viruses- the gain is worth the pain Detection of a group 2 coronavirus in dogs with canine infectious respiratory disease Human coronaviruses: what do they cause? |
| cord-016095-jop2rx61 | What can teaching, ex cathedra, do to guide the researcher? cord-016095-jop2rx61 , Stanislas DEHAENE( b. 1965), Daniel DENNETT( b. 1942) and others, that thought is not transcendent, and that it is intrinsically dependent on the brain, which is considered to be a neurochemical system, and thus look for the secret of the individuation of the human being in brain information storage mechanisms with retrocontrol loops associated with subtle neuron architectures, or, in short, refer to a sort of TURING machine? cord-016095-jop2rx61 Are the stakes involved in a particular experiment, in terms of the acquisition of new knowledge, worth the suffering of an animal used in that experiment? cord-016095-jop2rx61 At a scientific meeting held in Sheffield, England, in January of 2005 63, with the theme Systems biology: will it work?, an argumentative discussion of the advantages as well as the disadvantages of an integrated, mathematized biology was useful in that it included a reminder that most of the parameters used insystems biology"come from studies that are carried out in vitro on purified enzymes, and that it is not sufficient to know the value of the Michaelian parameters( V max and K m) in order to reach biological reality. |
| cord-016095-jop2rx61 | At what stage of embryo development is it possible to remove ES cells for experimental purposes? |
| cord-016095-jop2rx61 | How can the sum of the scattered experimental data that we have concerning the catalytic capabilities of a multitude of enzymes of cellular origin be integrated into the operation of a cell? |
| cord-016095-jop2rx61 | How can we envisage the gene- enzyme relationship according to current evidence concerning the complexity of the genetic message? |
| cord-016095-jop2rx61 | How could this be true if the teaching faculty did not itself participate in scientific creation? |
| cord-016095-jop2rx61 | In a text entitled Why genetic engineering should continue its battle 31, James WATSON writes of his confusion when faced with a choice that is likely to become more and more insistent over the years:"Dare we be entrusted with improving on the results of several million years of Darwinian natural selection? |
| cord-016095-jop2rx61 | In his What is Bioethics? |
| cord-016095-jop2rx61 | Innumerable cargoes have already reached port, but what will be the destiny of this precious merchandise? |
| cord-016095-jop2rx61 | Is it not necessary to ensure that the experimental protocol is well- documented, that it is not redundant, or even that it has been the subject of previous studies carried out on cells in culture? |
| cord-016095-jop2rx61 | Should"systems biology"be regarded as a resurgence of a physiology that has been somewhat neglected over the last few decades, but has been reinvigorated by a salutary hybridization of biologists and model- makers? |
| cord-016095-jop2rx61 | This example highlights a harrowing ethical dilemma: should we not treat a patient whose illness is likely to be fatal, or attempt a therapy that may save the patient, without having any formal assurance of its success? |
| cord-016095-jop2rx61 | With such an innovation, an unexpected field of exploration has opened up to research in domains as far apart as pharmacology and the science of evolution, giving rise to burning questions: could such non- natural proteins have therapeutic properties? |
| cord-016095-jop2rx61 | could they give a selective advantage to the organisms that host them? |
| cord-016095-jop2rx61 | or do the human germ cells represent on the contrary Rubicons that geneticists will never dare to cross? |
| cord-350423-yaeduwvb | (?) |
| cord-350423-yaeduwvb | But what are the physiological targets of this domain? |
| cord-350423-yaeduwvb | But what of the targets of this virally encoded PBM? |
| cord-350423-yaeduwvb | One of the most difficult questions to answer is which of E6 PDZ substrate(s) in the growing list are physiologically relevant targets? |
| cord-350423-yaeduwvb | So, is DLG1 inactivation necessary for T cell transformation by Tax? |
| cord-350423-yaeduwvb | cord-350423-yaeduwvb authors: James, Claire D.; Roberts, Sally title: Viral Interactions with PDZ Domain- Containing Proteins — An Oncogenic Trait? |
| cord-330852-n7j0c4ne | ( Fig. 6.5D)? |
| cord-330852-n7j0c4ne | ( Patargias et al., 2006): is the p7 bundle just sensitive to protons but does not conduct them? |
| cord-330852-n7j0c4ne | How can a protein be defined as a channel? |
| cord-330852-n7j0c4ne | How does knowledge about the mechanism of function fit into this wish? |
| cord-330852-n7j0c4ne | Or is p7 also a proton conductor similar to M2? |
| cord-330852-n7j0c4ne | Or is the interaction with the host to be seen as a kind of"host based ligand"closing the channel while without the host protein the channel is open; or do other ligands trigger activity? |
| cord-330852-n7j0c4ne | What makes knowledge of the mechanism of function so important? |
| cord-330852-n7j0c4ne | With further analogy to M2, the question arises, can the protein also be built by less than the six units as it is proposed to date? |
| cord-301827-a7hnuxy5 | A polypeptide chain at the folding- misfolding- nonfolding cross- roads: which way to go? |
| cord-301827-a7hnuxy5 | How can one develop tissue- specific drugs targeting such abundant proteins? |
| cord-301827-a7hnuxy5 | Polyglutamine diseases: a transcription disorder? |
| cord-301827-a7hnuxy5 | Prevalent structural disorder in E. coli and S. cerevisiae proteomes Large- scale analysis of thermostable, mammalian proteins provides insights into the intrinsically disordered proteome Archaic chaos: intrinsically disordered proteins in Archaea Reduction in structural disorder and functional complexity in the thermal adaptation of prokaryotes Intrinsic disorder in pathogenic and non- pathogenic microbes: discovering and analyzing the unfoldomes of early- branching eukaryotes How much of protein sequence space has been explored by life on Earth? |
| cord-301827-a7hnuxy5 | Regular arrangement on the peptidoglycan and unusual dodecyl sulfate binding Proposed knobs- intoholes packing for several membrane proteins Folding patterns of porin and bacteriorhodopsin Hydrophobic organization of membrane proteins Are membrane proteins"inside- out"proteins? |
| cord-301827-a7hnuxy5 | The effect of salts on the activity and stability of Escherichia coli and Haloferax volcanii dihydrofolate reductases Halophilic adaptation of protein- DNA interactions Unique amino acid composition of proteins in halophilic bacteria Molecular signature of hypersaline adaptation: insights from genome and proteome composition of halophilic prokaryotes Structural basis for the aminoacid composition of proteins from halophilic archea Electrostatic contributions to the stability of halophilic proteins Viral disorder or disordered viruses: do viral proteins possess unique features? |
| cord-301827-a7hnuxy5 | The importance of being unfolded Heterogeneity of the binding sites of bovine serum albumin Structural studies of p21 Waf1/ Cip1/ Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity What properties characterize the hub proteins of the protein- protein interaction network of Saccharomyces cerevisiae? |
| cord-301827-a7hnuxy5 | The refined crystal structures of the bovine trypsinogen- pancreatic trypsin inhibitor complex and of its ternary complex with Ile- Val at 1.9 A resolution Intrinsic disorder in the Protein Data Bank Protein disorder and the evolution of molecular recognition: theory, predictions and observations Intrinsically unstructured proteins: re- assessing the protein structurefunction paradigm Why are"natively unfolded"proteins unstructured under physiologic conditions? |
| cord-301827-a7hnuxy5 | What does it mean to be natively unfolded? |
| cord-301827-a7hnuxy5 | What's in a name? |
| cord-339091-3xk2w0d2 | Are apparently high- scoring matches real or an artefact of search methodology? |
| cord-339091-3xk2w0d2 | Are bacterial vaccine antigens T- cell epitope depleted? |
| cord-339091-3xk2w0d2 | But how can we progress beyond this rather inexactly- specified philosophical standpoint to something which is practically useful when we select vaccine candidates? |
| cord-339091-3xk2w0d2 | EPIMHC: a curated database of MHC- binding peptides for customized computational vaccinology AntiJen: a quantitative immunology database integrating functional, thermodynamic, kinetic, biophysical, and cellular data JenPep: a novel computational information resource for immunobiology and vaccinology JenPep: a database of quantitative functional peptide data for immunology Bacterial virulence: can we draw the line? |
| cord-339091-3xk2w0d2 | Have we cut ourselves too short in mapping CTL epitopes? |
| cord-339091-3xk2w0d2 | It would indeed be wonderful if the identification of candidate vaccines was really and consistently this simple and systematic? |
| cord-339091-3xk2w0d2 | Obviously, all the same caveats that exist for any sequence search hold here also: which thresholds are appropriate? |
| cord-338485-4zqeq1se | : What mark will we leave on the planet? |
| cord-338485-4zqeq1se | Can we cut out the meat of the dish? |
| cord-338485-4zqeq1se | Cultural, culinary, economic and psychological factors Help the climate, change your diet: A crosssectional study on how to involve consumers in a transition to a low- carbon society Meatless days"or"less but better"? |
| cord-338485-4zqeq1se | Planet, profit, plus people? |
| cord-338485-4zqeq1se | Reducing meat consumption in today's consumer society: Questioning the citizen- consumer gap Evaluating the environmental impacts of dietary recommendations Pursuing a low meat diet to improve both health and Sustainability: How can we use the frames that shape our meals? |
| cord-338485-4zqeq1se | Sustainable protein production and consumption: Pigs or peas? |
| cord-338485-4zqeq1se | The environmental impact of fertilizer embodied in a wheat- to- bread supply chain Green protein growth plan-hand in hand towards The nutritional transition in Western Europe Trimming the excess: Environmental impacts of discretionary food consumption in Australia Consumer perception and behaviour regarding sustainable protein consumption: A systematic review Can increased organic consumption mitigate climate changes? |
| cord-338485-4zqeq1se | The protein shift: Will Europeans change their diet? |
| cord-319780-rfj9t99r | A molecular docking study Can angiotensin receptor- blocking drugs perhaps be harmful in the COVID-19 pandemic? |
| cord-319780-rfj9t99r | For example, what are the mechanism/ s underlying why some sufferers of hypertension and/or diabetes might be at higher risk( https://www.immunopaedia.org.za/breakingnews/why-are-hypertension-and-diabetes-patients-at-high-risk-of-severe-covid-19/)? |
| cord-319780-rfj9t99r | How will the evolution of the virus alter rates of infection and the severity of symptoms? |
| cord-319780-rfj9t99r | Is nicotine exposure linked to cardiopulmonary vulnerability to COVID-19 in the general population? |
| cord-319780-rfj9t99r | Is there evidence from the SARS and MERS outbreaks to suggest a commonality of susceptibility? |
| cord-319780-rfj9t99r | Is there evidence that patients on ACE inhibitors or angiotensin receptor blockers were at higher risk with SARS- CoV and MERS- CoV infections and, currently, for SARS- CoV-2 infection? |
| cord-319780-rfj9t99r | N is a receptor for human coronavirus 229E Enteric involvement of coronaviruses: is faecal- oral transmission of SARS- CoV-2 possible? |
| cord-319780-rfj9t99r | Underestimated Opportunistic Pathogens of the Central Nervous System? |
| cord-319780-rfj9t99r | What factor/ s determine resistance to infection? |
| cord-319780-rfj9t99r | What is the impact of contracting the virus on individuals with other underlying conditions? |
| cord-006636-xgikbdns | (? S.). |
| cord-006636-xgikbdns | (? S.). |
| cord-006636-xgikbdns | (? S.). |
| cord-006636-xgikbdns | -geeignet, den Vertrieb yon Hackfleiseh befriedigend zu regeln? |
| cord-006636-xgikbdns | 8eh~ digungen dutch Konservlerungsmittel bei Zitrusfrfichten? |
| cord-006636-xgikbdns | I. Pantothenic acid content in Japanese foods Haben wir Mangel an essentiellen Fettsiiurcn? |
| cord-006636-xgikbdns | Is there a hemostatie effect of peanuts in hemophilioid disorders? |
| cord-006636-xgikbdns | Lst es zu vcrtreten, dab das Fleisch schwacbfinniger Rinder auch in gebr~ tetem Zustand eingefroren wird? |
| cord-006636-xgikbdns | Some aspects of the relation of nutrition and pregnancy Is coronary heart disease preventable? |
| cord-006636-xgikbdns | The diet in renal faiIure Is the rationale for gaetrointestinal diet therapy sound? |
| cord-006636-xgikbdns | Vitamin Blz- Behandlung vertretbar? |
| cord-006636-xgikbdns | an alkoholhaltige Siigwaren zu stellen? |
| cord-006636-xgikbdns | m Liehte der mathematisehen Analyse der Bestimmungen der Fleischbcschau yon Schweinefleisch mSglieh? |
| cord-006636-xgikbdns | mathematischen Analyse der Bestimmungen der Fleischbesehau yon Schweinefleiseh mSglich? |
| cord-006636-xgikbdns | nd eingcfrorcn wird? |
| cord-006636-xgikbdns | unsere Kos~ und unsere Kostgewohnheiten beeinflussen? |
| cord-006636-xgikbdns | ~hrung 11 Moderne Vitamin B~-Therapie: oral, rektal oder parenteral? |
| cord-006636-xgikbdns | ~hrung in Deutschland? |
| cord-006636-xgikbdns | ~renteral? |
| cord-006636-xgikbdns | ~trio surgery Koehsalzarme Kost und Nierenerkrankungen Theoretische und praktische Grundiagen der Ernilhrung in der Fett in der Diabeteskost Foods or supplements? |
| cord-001835-0s7ok4uw | 3) Can an exhaustive statistical scan of a large, recent dataset identify new side chain interactions at helix termini? |
| cord-001835-0s7ok4uw | A Promoter or Inhibitor for IAPP aggregation? |
| cord-001835-0s7ok4uw | An empirical framework for binary interactome mapping Estimating the size of the human interactome Coming to peace with protein complexes? |
| cord-001835-0s7ok4uw | Are they essential in carrying out a specific cellular function? |
| cord-001835-0s7ok4uw | But the general effects on traits relevant at atomic/ residue resolutions have been less studied, and one fundamental issue remains unsolved: to what extent are proteins forced into interactions with highly concentrated solutes, and with what direct consequences? |
| cord-001835-0s7ok4uw | Can Bio- functionalities be deciphered from protein sequence information using computational approaches? |
| cord-001835-0s7ok4uw | Can site- directed mutagenesis shed light on the refolding pattern of human glucose 6-phosphate dehydrogenase( G6PD)? |
| cord-001835-0s7ok4uw | Can the structure of a protein( H3.1) depend on the treatment of a solvent medium( explicit vs effective) in a coarse- grained computer simulation? |
| cord-001835-0s7ok4uw | Do they play a regulatory role in controlling the on and off of a certain cellular process? |
| cord-001835-0s7ok4uw | How did enzymes, the catalysts of many crucial cellular processes, achieve this cold adaptation? |
| cord-001835-0s7ok4uw | In a protein engineering context, do we need to take into account the dynamics in order to maximize the fitness and function of the resulting proteins? |
| cord-001835-0s7ok4uw | Is there evolutionary pressure to conserve dynamics? |
| cord-001835-0s7ok4uw | Is this necessary to retain functionality, as it has been suggested? |
| cord-001835-0s7ok4uw | Protein engineering: what's next? |
| cord-001835-0s7ok4uw | Questions under- investigation includes what are the effects of mutations( e.g. b- and g- synuclein), how does the structure of an isolated ASN chain change in presence of many interacting protein chains, and how do they organize over the multiple length scales? |
| cord-001835-0s7ok4uw | To what extent are helix- terminal motifs that include multiple amino acids likely to represent genuine cooperative interactions between side chains, rather than chance alignments? |
| cord-001835-0s7ok4uw | Which particular helix- terminal loop geometries are favored by each side chain interaction? |
| cord-266543-ng9zr299 | : are we looking for the appropriate properties? |
| cord-266543-ng9zr299 | Are homology models of G- protein coupled receptors suitable targets? |
| cord-266543-ng9zr299 | Binding affinity: a sufficiently well understood property? |
| cord-266543-ng9zr299 | Does the selected protein exhibit a binding pocket that can be successfully targeted by small molecule ligands? |
| cord-266543-ng9zr299 | How diverse should the entries of a compound database used for screening be? |
| cord-266543-ng9zr299 | How does consensus scoring work for virtual library screening? |
| cord-266543-ng9zr299 | How many leads from HTS? |
| cord-266543-ng9zr299 | How many leads from HTS? |
| cord-266543-ng9zr299 | How well do they cover chemical space, and which portion of this space represents druglike molecules? |
| cord-266543-ng9zr299 | How well is the available chemical space covered? |
| cord-266543-ng9zr299 | However, are such sample pools biased? |
| cord-266543-ng9zr299 | In light of these considerations, what is a suitable compound collection? |
| cord-266543-ng9zr299 | Is it advisable to focus scoring on free energy or would it be better to treat enthalpy and entropy as separate terms in the scoring[ 123]? |
| cord-266543-ng9zr299 | Is there an optimal size for candidate ligands to be submitted to screening? |
| cord-266543-ng9zr299 | Required accuracy of scoring: enrichment or hit identification? |
| cord-266543-ng9zr299 | The disadvantage of this strategy is the fact that additional degrees of scoring are created: what discriminates the scoring against different protein conformers? |
| cord-266543-ng9zr299 | Virtual screening using protein- ligand docking: avoiding artificial enrichment Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings A rule- of- three for fragment- based lead discovery ADMET in silico modelling: towards prediction paradise? |
| cord-266543-ng9zr299 | What is'diverse'in this context? |
| cord-266543-ng9zr299 | What physicochemical properties have to be met by the candidates to guarantee sufficient bioavailability? |
| cord-342756-rgm9ffpk | -What happens next? |
| cord-342756-rgm9ffpk | : what to expect for COVID-19? |
| cord-342756-rgm9ffpk | COVID-19 and diabetes: Can DPP4 inhibition play a role? |
| cord-342756-rgm9ffpk | COVID-19, SARS and MERS: are they closely related? |
| cord-342756-rgm9ffpk | DPP4 inhibition: preventing SARS- CoV-2 infection and/or progression of COVID-19? |
| cord-342756-rgm9ffpk | Protein- protein interactions of viroporins in coronaviruses and paramyxoviruses: new targets for antivirals? |
| cord-342756-rgm9ffpk | The importance of hypertension as a risk factor for severe illness and mortality in COVID-19 Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 in Wuhan, China: a retrospective study Diabetes is a risk factor for the progression and prognosis of COVID-19 Older people and COVID-19: isolation, risk and ageism Asymptomatic carriers of COVID-19 as a concern for disease prevention and control: more testing, more follow- up Drug repositioning: identifying and developing new uses for existing drugs Drug repurposing from the perspective of pharmaceutical companies Drug repurposing: progress, challenges and recommendations Emerging virus diseases: can we ever expect the unexpected? |
| cord-342756-rgm9ffpk | and COVID-19: serendipity or opportunity for intervention? |
| cord-342756-rgm9ffpk | should inhibitors of the renin- angiotensin system be withdrawn in patients with COVID-19? |
| cord-342756-rgm9ffpk | what lessons have we learned? |
| cord-325559-di8lljoi | Does SARS- CoV-2 Trigger Stress- Induced Autoimmunity by Molecular Mimicry? |
| cord-325559-di8lljoi | Furthermore, can there be protective factors? |
| cord-325559-di8lljoi | Furthermore, can there be protective factors? |
| cord-325559-di8lljoi | Is COVID-19 a proteiform disease inducing also molecular mimicry phenomena? |
| cord-325559-di8lljoi | It Is Pneumonia? |
| cord-325559-di8lljoi | The Columbus'egg? |
| cord-325559-di8lljoi | What are the main clues that epidemiology and the clinics provide to date? |
| cord-325559-di8lljoi | What are the predisposing factors? |
| cord-325559-di8lljoi | What are the predisposing factors? |
| cord-325559-di8lljoi | What proteins? |
| cord-325559-di8lljoi | What proteins? |
| cord-325559-di8lljoi | Which cells? |
| cord-325559-di8lljoi | Which cells? |
| cord-325559-di8lljoi | Why should severe acute respiratory syndrome coronavirus 2( SARS- CoV-2) not be considered one of these? |
| cord-318853-mxyxwkhx | 5 5'UTR geq/ ml at 16 weeks be visible immunologically, but envelope proteins derived from EeRNA sequences corresponding to~10 6- 7 5'UTR geq/ ml at 4- 6 weeks remain unseen? |
| cord-318853-mxyxwkhx | Analysis of cloned DNA gives cleaner data than PCR sequencing but if 100 clones( and multiple HCV quasispecies clones are highly unlikely to be identical) provides definitive sequence, would we process the 101 st to reveal different and, potentially, critical sequence variations? |
| cord-318853-mxyxwkhx | And if we did, how would we recognise its importance? |
| cord-318853-mxyxwkhx | As clear evidence exists for viral disruption of leptin function[ 106] and virus- associated weight gain in humans[ 107] and monkeys[ 108], is it possible the global epidemics of type II diabetes mellitus, insulin resistance, hyperlipidaemia and obesity now prevalent[ 109][ 110][ 111][ 112][ 113][ 114][ 115][ 116], are just that; epidemics fundamentally caused by viruses that co- opt insulin or leptin or other associated receptors for cell access and generate protein quasispecies that disrupt receptor function? |
| cord-318853-mxyxwkhx | But does this certitude reflect reality, at least for viral RNA quasispecies? |
| cord-318853-mxyxwkhx | But why should specific EeRNA sequence frequencies-in other words, HCV RNA pol fidelity-increase after week 8, facilitating adaptive immune responses? |
| cord-318853-mxyxwkhx | Could it also be that ethnically based epidemics of obesity, diabetes mellitus, hypertension and reno- vascular disease( the'metabolic syndrome'), as seen in PIMA Indians, Nauruans and Australian Aborigines[ 115] have developed not primarily because of exposure to"Western"foods and lifestyles-that, after all, are all- pervasive without necessarily having so dramatic an effect on other groups-but because of chronic or recurrent exposure to viruses, or genotypes of viruses to which their particular repertoire of receptor polymorphisms confer no protection? |
| cord-318853-mxyxwkhx | Finally, if immune mechanisms are unable to clear RNA viruses like HCV and do not cause the reduced viral replication seen during acute infection, are they any more likely to be effective against other RNA viruses? |
| cord-318853-mxyxwkhx | I receptor signaling system in JC virus T antigen- induced primitive neuroectodermal tumors-medulloblastomas Hepatitis C virus down- regulates insulin receptor substrates 1 and 2 through up- regulation of suppressor of cytokine signaling 3 Vaccinia virus and the EGF receptor: a portal for infectivity? |
| cord-318853-mxyxwkhx | Is important sequence likely to be present at frequencies of http://www.virologyj.com/content/2/1/70< 1%? |
| cord-318853-mxyxwkhx | Is it possible foetal tolerance is mediated by regulating the fidelity of foetal DNA dependent RNA transcriptases to ensure any cell- surface antigens are expressed heterogeneously and at levels below the threshold of maternal immune responsiveness? |
| cord-318853-mxyxwkhx | Is it possible that self- limiting infections like influenza and SARS also autoregulate their replication, and, like HCV or HBV, become partially dormant, yet remain transcriptionally active, in the face of an active and powerful immune response? |
| cord-318853-mxyxwkhx | The expected consequences disruption of receptor function by variant viral proteins might explain many common biochemical pathologies; For example, what effect would chronic blockade of parathyroid( PTH) receptors by viral proteins have on PTH levels, the parathyroid glands, or bone? |
| cord-318853-mxyxwkhx | This is certainly an accurate synthesis of an extensive and highly complex literature but does it make any sense? |
| cord-318853-mxyxwkhx | What practical meaning does"immune control"have for the individual? |
| cord-318853-mxyxwkhx | Why should HCV replicating at 10 6- 7 geq/ ml at week 6 be invisible to the immune system but visible when replicating at 10 5 geq/ ml long term? |
| cord-320092-0qnvydux | A basic question that might arise is: what exactly makes the pathobiology and disease course of these particular viruses unique? |
| cord-320092-0qnvydux | And, could it be that, in addition to viral replication inside the particular types of human host cells, other intracellular processes specific to these viruses are involved? |
| cord-320092-0qnvydux | COVID-19 does not Lead to a"typical"acute respiratory distress syndrome Biochemical and molecular identification of a novel hepcidin type 2-like antimicrobial peptide in the skin mucus of the pufferfish Takifugu pardalis Hyperferritinemia in critically ill COVID-19 patients-is ferritin the product of inflammation or a pathogenic mediator? |
| cord-320092-0qnvydux | COVID-19-related coagulopathy- is transferrin a missing link? |
| cord-320092-0qnvydux | Could systemic changes in serum iron levels[ 60, 114, 126, 141]( with a possible view on the degree of abovenormal serum ferritin in patients[ 25, 26]) or levels of hepcidin itself be detected in patients with varying COVID-19 severities? |
| cord-320092-0qnvydux | Could the cytoplasmic tail even coordinate and bind iron? |
| cord-320092-0qnvydux | Could, for instance, clinical evidence be gathered to clarify if disorders of iron homeostasis might exacerbate symptoms in COVID-19 patients? |
| cord-320092-0qnvydux | Does pathological iron overload impair the function of human lungs? |
| cord-320092-0qnvydux | Does the pathogenesis of SARS- CoV-2 virus decrease at high- altitude? |
| cord-320092-0qnvydux | Given the prominence of cysteines in the aligned motif( Fig. 1a), how are they utilized in the respective similar domains? |
| cord-320092-0qnvydux | How could these relate to hepcidin biology? |
| cord-320092-0qnvydux | If the sequence similarity reported here is actually playing a significant role at the cellular level, could it be that, although the cellular localizations appear to be different based on current knowledge, the SARS- CoV-2 spike protein cytoplasmic tail can partly mimic the structure of hepcidin and interact with ferroportin? |
| cord-320092-0qnvydux | Multisystem inflammatory syndrome in children in New York state Lack of association between New Haven coronavirus and Kawasaki disease Iron: innocent bystander or vicious culprit in COVID-19 pathogenesis? |
| cord-320092-0qnvydux | [ 95]) be explainable in part by a link to hepcidin? |
| cord-320092-0qnvydux | a descriptive study Is the prevalence of anemia in children living at high altitudes real? |
| cord-320092-0qnvydux | first, does the spike protein, similar to hepcidin, potentially promote iron sequestration in( alveolar) macrophages[ 85] and hence impede the host's initial immunological response? |
| cord-022940-atbjwpo5 | , What is the role of Ministry of Health? |
| cord-022940-atbjwpo5 | Are antibiotics against which the strain is resistant inducing the changes in bacterial proteome? |
| cord-022940-atbjwpo5 | Can YKL-40 be an inflammatory biomarker in vitamin D deficiency? |
| cord-022940-atbjwpo5 | Hemolysis and test rejection: are we following a reliable process? |
| cord-022940-atbjwpo5 | His- flag tag as a fusion partner in insect expression systemgain or loss? |
| cord-022940-atbjwpo5 | How does different lead levels affect TSH, FT3, FT4, vitamin B12 and folate? |
| cord-022940-atbjwpo5 | How preeclampsia affects oxidant status and antiinflammatory potential of breast milk? |
| cord-022940-atbjwpo5 | Is this strain characterized by other differences on a proteome level? |
| cord-022940-atbjwpo5 | It was intended to shed light on some questions such as, what is the place and importance of IVD in Turkey? |
| cord-022940-atbjwpo5 | MRM transitions used were m/ z? 250/164 for 8-iso- PGF 2a and m/ z? |
| cord-022940-atbjwpo5 | MRM transitions used were m/ z? 250/164 for 8-iso- PGF 2a and m/ z? |
| cord-022940-atbjwpo5 | Medical and biological illustrations for life sciences education: Is'a picture worth a thousand words'in visualizing medicine and science? |
| cord-022940-atbjwpo5 | P-04.01.1- 006 Host- pathogen interactions: is there a relationship between TLR 4 polymorphisms and tuberculosis in a group of Turkish patients? |
| cord-022940-atbjwpo5 | P-05.01.1- 015 Does causes 1800 MHz magnetic field application KRAS and P53 mutations in colon?: |
| cord-022940-atbjwpo5 | P-09.04.4- 108 Is there any relation between 50 g oral glucose challenge test and serum total oxidant- antioxidant status in pregnant woman? |
| cord-022940-atbjwpo5 | What are the responsibilities of educational institutions? |
| cord-022940-atbjwpo5 | What is extra to learn from protein drying measurements? |
| cord-004584-bcw90f5b | ( Na? dependent)[ 4]. |
| cord-004584-bcw90f5b | / H? |
| cord-004584-bcw90f5b | /H? |
| cord-004584-bcw90f5b | /H? |
| cord-004584-bcw90f5b | /H? |
| cord-004584-bcw90f5b | /H? |
| cord-004584-bcw90f5b | 4000 lmol photons m-2 s-1) have shown that fast component of ms- DF was inhibited faster with time than in case of action of Co 2? and excess light. |
| cord-004584-bcw90f5b | 7, 1518 Budapest, HungaryWide- line proton NMR FID, echoes, spin- lattice and spin- spin relaxation times were measured at 82.55 MHz frequency in the-70 ° C to? |
| cord-004584-bcw90f5b | A putative outer- membrane cytochrome, OmcF, is crucial for Fe 3? |
| cord-004584-bcw90f5b | A recent candidate for pH regulation within early endosomes and TGN is the highly conserved intracellular Na? |
| cord-004584-bcw90f5b | Acyl transfer from lipids without enzyme catalysis: a new paradigm for membrane protein ageing? |
| cord-004584-bcw90f5b | Additional studies have shown that although neither the catalytic reaction nor the establishment of the DpH requires the presence of Na?, the presence of this ion increased the proton transport. |
| cord-004584-bcw90f5b | Analyzing the fluorescence relaxation kinetics,? |
| cord-004584-bcw90f5b | Ca 2? |
| cord-004584-bcw90f5b | Ca 2? and Mn 2?, that can be attributed to their sizes and coordination properties to specific ligands. |
| cord-004584-bcw90f5b | Ca 2? and Mn 2?, that can be attributed to their sizes and coordination properties to specific ligands. |
| cord-004584-bcw90f5b | Ca?? |
| cord-004584-bcw90f5b | Ca?? |
| cord-004584-bcw90f5b | Cell migration or proliferation? |
| cord-004584-bcw90f5b | ClpB is a hexameric AAA? |
| cord-004584-bcw90f5b | Combining all these results, a model for the coupling mechanism of complex I was proposed, suggesting the presence of two different energy coupling sites, one that works only as a proton pump( Na? independent), and the other functioning as a Na? |
| cord-004584-bcw90f5b | Combining all these results, a model for the coupling mechanism of complex I was proposed, suggesting the presence of two different energy coupling sites, one that works only as a proton pump( Na? independent), and the other functioning as a Na? |
| cord-004584-bcw90f5b | Compared to these channels, the voltage- dependence of TRPA1 is very weak( apparent number of gating charges* 0.4 versus 12 in K? channels) and its putative voltage- sensing domain most likely lies outside the S4 because TRPA1 completely lacks positively charged residues in this region. |
| cord-004584-bcw90f5b | Cytoplasmic dynein moves through uncoordinated action of the AAA1 ring domains Ahmet Yildiz Department of Physics, and Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720 USA Cytoplasmic dynein is a homodimeric AAA? |
| cord-004584-bcw90f5b | During action on chloroplasts only of Cd 2? |
| cord-004584-bcw90f5b | Forward and reverse transport directions were investigated at zero membrane potential using preparations with inside out and right side out oriented transporters with Na? or H? |
| cord-004584-bcw90f5b | Furthermore, Na? |
| cord-004584-bcw90f5b | Generalized epilepsy with febrile seizures plus( GEFS?, OMIM 604233) is a childhood genetic epilepsy syndrome correlated to mutations in the ancillary b- subunit of neuronal voltage- gated sodium channels( NaChs). |
| cord-004584-bcw90f5b | I reduce ubiquinone, it is suggested that the Na?/H? |
| cord-004584-bcw90f5b | I reduce ubiquinone, it is suggested that the Na?/H? |
| cord-004584-bcw90f5b | In addition, our systematic and quantitative analysis( in combination with genetic modifications) provides a tool to study the role of? |
| cord-004584-bcw90f5b | In both strains the pH dependence was associated with a systematic increase of the K m for Na? |
| cord-004584-bcw90f5b | In the photosynthetic reaction center( RC) of Rhodobacter sphaeroides, fast formation of the charge separated state P? |
| cord-004584-bcw90f5b | In the present work, Al 3? induced conformational change and instant oligomerization of aS have been studied using FRET and FCS as main techniques. |
| cord-004584-bcw90f5b | In the shorter(\ 1 ms) time scale, the dominating effect is the re- reduction of the oxidized primary donor( P?? |
| cord-004584-bcw90f5b | In the shorter(\ 1 ms) time scale, the dominating effect is the re- reduction of the oxidized primary donor( P?? |
| cord-004584-bcw90f5b | Initial expression levels were determined by either partial purification using Ni 2?-NTA |
| cord-004584-bcw90f5b | It was observed that the Na? |
| cord-004584-bcw90f5b | It was observed that this bacterial complex I is able of H? |
| cord-004584-bcw90f5b | K? |
| cord-004584-bcw90f5b | Nigericin, a peptide that acts as an H?-K? |
| cord-004584-bcw90f5b | Nigericin, a peptide that acts as an H?-K? |
| cord-004584-bcw90f5b | Result indicates that damage sites of action Cd 2? |
| cord-004584-bcw90f5b | Simultaneous action of Cd 2? and photoinhibitory illumination( |
| cord-004584-bcw90f5b | Taken together with our results on the subcellular localization of the native NHE7, these unique biochemical features provide new insights on the biological function and pathological implications of this intracellular Na? |
| cord-004584-bcw90f5b | The aim of these studies was to clarify whether the specific crystalline structure of protein and protein- substrate interactions are significant for H? |
| cord-004584-bcw90f5b | The available data are restricted and only the re- oxidation of the reduced primary quinone( Q A-? |
| cord-004584-bcw90f5b | The average lifetime of donor in the presence of acceptor increases with the increase of Al 3? |
| cord-004584-bcw90f5b | The coupling ion of the system was shown to be the H? |
| cord-004584-bcw90f5b | The first and best characterized GEFS? |
| cord-004584-bcw90f5b | The intrinsic Tyr fluorescence rises sharply within the mixing dead time, reflecting an enhanced hydrophobicity of the Tyr environment and a fast conformational change of aS. Al 3? |
| cord-004584-bcw90f5b | The simultaneous effect of photoinhibitory illumination and toxic action of heavy metals ions( Cd 2? |
| cord-004584-bcw90f5b | The steadystate level at Cd 2? |
| cord-004584-bcw90f5b | The transmembrane part of the tetrameric TRPA1 is structurally related to the voltagegated K? channels in which the conserved charged residues within the fourth transmembrane region( S4) constitute part of a voltage sensor. |
| cord-004584-bcw90f5b | These data allowed to advance a transport mechanism based on competing Na? |
| cord-004584-bcw90f5b | This inner structure transmits local signals due to ATP binding and hydrolysis by AAA? domains. |
| cord-004584-bcw90f5b | This model was reinforced by further studies performed in the presence of the Na? |
| cord-004584-bcw90f5b | This work was supported by the Italian Association for Cancer Research( AIRC), the Istituto Toscano Tumori and the Associazione Noi per Voi Differential hydration, void volume: which factor provides the main contribution to DV u? |
| cord-004584-bcw90f5b | Thus, notable variations in the RNA binding specificity was observed for the divalent ions of Mg 2? |
| cord-004584-bcw90f5b | Under symmetrical Na? |
| cord-004584-bcw90f5b | Under symmetrical pH conditions with a Na? |
| cord-004584-bcw90f5b | We assume that binding site of Cd 2? is Y Z or CaMn 4-cluster, one of the recombination partners with P 680? |
| cord-004584-bcw90f5b | We assume that binding site of Cd 2? is Y Z or CaMn 4-cluster, one of the recombination partners with P 680? |
| cord-004584-bcw90f5b | We have developed somatic cell genetic techniques that enable the selection of variant cells able to resist H? |
| cord-004584-bcw90f5b | We reported previously that the increase of the cholesterol content of the cell membrane( in vitro) modified the biophysical parameters of the gating of Kvl.3 K? ion channels in human T- lymphocytes. |
| cord-004584-bcw90f5b | What makes an amyloid toxic: morphology, structure or interaction with membranes? |
| cord-004584-bcw90f5b | Whole- cell K? |
| cord-004584-bcw90f5b | and Co 2? are donor and acceptor side of PS2, accordingly. |
| cord-004584-bcw90f5b | and Co 2?) |
| cord-004584-bcw90f5b | and H? |
| cord-004584-bcw90f5b | and Na? |
| cord-004584-bcw90f5b | and U 6? reduction and also for microbial electricity production( 4). |
| cord-004584-bcw90f5b | being transported to the periplasm, contributing in this way to the establishment of the electrochemical potential difference, while Na? is translocated to the cytoplasm[ 4]. |
| cord-004584-bcw90f5b | both alkaline pH and Na? |
| cord-004584-bcw90f5b | by extracellular Ca 2? entry probably through mechanosensitive channels. |
| cord-004584-bcw90f5b | concentration, indicating aS adopts a more extended conformation upon Al 3? |
| cord-004584-bcw90f5b | hERG K? channels is associated with increased risk of arrhythmias. |
| cord-004584-bcw90f5b | killing through plasma membrane expression of H? extruders. |
| cord-004584-bcw90f5b | the fast component of ms- DF, which originates via radiative recombination of reaction center with the CaMn 4-cluster or Y Z on donor side of PS2, is inhibited stronger than at action of only Co 2?. |
| cord-004584-bcw90f5b | treatment is remain stable, while at Co 2? |