bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
respiratory syndrome	21544
acute respiratory	21529
severe acute	18071
novel coronavirus	13801
syndrome coronavirus	10716
coronavirus disease	10454
spike protein	6077
public health	5142
sars coronavirus	4903
cord uid	4563
doc id	4563
immune response	4396
middle east	4200
severe covid	4058
converting enzyme	4037
east respiratory	3990
author funder	3860
granted medrxiv	3841
viral rna	3636
copyright holder	3600
clinical characteristics	3582
respiratory tract	3429
viral load	3375
health care	3328
respiratory distress	3273
version posted	3194
hong kong	3137
world health	3040
infectious diseases	2975
clinical trials	2946
health organization	2838
amino acid	2818
systematic review	2762
distress syndrome	2739
coronavirus infection	2678
cytokine storm	2672
united states	2637
risk factors	2613
cov infection	2596
peer review	2590
immune responses	2583
viral infection	2561
epithelial cells	2547
nucleic acid	2497
intensive care	2448
immune system	2405
human coronavirus	2401
hospitalized patients	2385
critically ill	2330
clinical features	2300
infected patients	2246
viral replication	2241
virus infection	2227
host cell	2214
patients infected	2173
sars patients	2148
rights reserved	2133
made available	2107
spike glycoprotein	2099
viral infections	2069
influenza virus	1981
lung injury	1958
infectious disease	1948
international license	1939
binding domain	1937
healthcare workers	1926
medrxiv preprint	1925
new coronavirus	1884
cohort study	1881
neutralizing antibodies	1846
innate immune	1833
type i	1829
receptor binding	1806
clinical trial	1792
confirmed cases	1773
ill patients	1754
convalescent plasma	1736
infection control	1719
disease control	1669
host cells	1626
respiratory failure	1615
ace expression	1614
pregnant women	1593
severe disease	1592
symptom onset	1577
coronavirus spike	1571
sars cov	1563
cl pro	1555
care workers	1552
cell entry	1551
mechanical ventilation	1544
gene expression	1525
disease severity	1521
incubation period	1521
human ace	1513
ace receptor	1513
antiviral activity	1482
may also	1472
infected cells	1470
lopinavir ritonavir	1465
rna polymerase	1465
coronavirus pneumonia	1448
main protease	1436
amino acids	1434
human coronaviruses	1422
antibody responses	1404
clinical course	1400
rna viruses	1397
viral entry	1395
case series	1392
chest ct	1390
inflammatory cytokines	1389
respiratory disease	1383
upper respiratory	1370
chain reaction	1330
respiratory symptoms	1315
care unit	1311
structural proteins	1302
mortality rate	1295
polymerase chain	1282
nucleocapsid protein	1281
protective equipment	1265
nervous system	1264
tested positive	1246
increased risk	1246
sars outbreak	1222
performed using	1209
inflammatory response	1197
kcal mol	1195
like protease	1193
confirmed covid	1191
severe cases	1179
associated coronavirus	1167
personal protective	1156
ebola virus	1153
coronavirus infections	1145
endothelial cells	1139
membrane fusion	1134
cancer patients	1133
active site	1130
animal models	1129
authors declare	1126
social distancing	1124
virus replication	1114
without permission	1109
reuse allowed	1105
allowed without	1105
viral shedding	1105
new york	1103
angiotensin ii	1103
lower respiratory	1103
fatality rate	1098
mental health	1085
neutralizing antibody	1064
binding affinity	1051
reverse transcription	1038
crystal structure	1035
respiratory viruses	1027
case report	1020
acute lung	1012
cell lines	1009
respiratory syncytial	998
among patients	995
immune cells	994
antiviral drugs	988
general population	976
nasopharyngeal swab	974
previous studies	966
viral genome	963
protease inhibitor	963
viral proteins	962
cell responses	962
monoclonal antibodies	961
molecular docking	961
control measures	959
infected pneumonia	957
syncytial virus	957
monoclonal antibody	952
viral loads	949
dependent rna	946
cell culture	942
heart failure	930
serum samples	929
vaccine development	928
significantly higher	926
coronavirus associated	925
global health	920
binding site	913
angiotensin converting	912
high risk	906
clinical symptoms	905
close contact	904
room temperature	901
first case	900
present study	899
higher risk	881
important role	878
human transmission	875
statistically significant	872
cell types	867
cardiovascular disease	866
retrospective cohort	865
test results	861
infected individuals	860
cell surface	849
recent study	844
peripheral blood	844
respiratory infections	839
cov spike	835
supplementary table	833
antibody response	833
spike proteins	831
avian influenza	828
protease inhibitors	826
risk factor	822
hubei province	818
rna virus	818
molecular dynamics	815
cleavage site	815
virus entry	814
stem cells	813
severe respiratory	803
dendritic cells	793
drug repurposing	792
orf ab	787
observational study	785
central nervous	785
corona virus	785
drug discovery	784
transmission dynamics	781
high levels	781
functional receptor	781
clinical outcomes	776
control group	774
human respiratory	766
bat origin	761
reactive protein	758
immunodeficiency virus	756
viral particles	756
saudi arabia	752
stranded rna	751
closely related	749
gastrointestinal symptoms	741
informed consent	741
nasopharyngeal swabs	740
mg ml	737
clinical manifestations	736
igg antibodies	735
en el	734
controlled trial	734
contact tracing	732
receptor ace	732
descriptive study	727
large number	724
pneumonia outbreak	722
specific antibodies	722
hydrogen bonds	721
sars epidemic	720
clinical studies	717
case fatality	717
innate immunity	715
vero cells	713
severe pneumonia	713
pl pro	712
side effects	712
previously described	708
human immunodeficiency	707
electron microscopy	697
vertical transmission	689
diabetes mellitus	689
target cells	688
another study	686
angiotensin system	686
time rt	685
type ii	684
pcr testing	680
randomized clinical	679
coronavirus sars	678
transplant recipients	677
retrospective study	674
respiratory infection	672
asymptomatic patients	668
structural basis	668
serine protease	667
cell epitopes	666
positive patients	662
health emergency	662
cov cl	661
genome sequence	659
free energy	656
organ failure	656
global pandemic	654
recent studies	654
also found	653
nk cells	653
least one	651
pcr test	650
adaptive immune	647
hepatitis virus	645
close contacts	645
significant difference	644
total number	644
cell line	643
sample size	641
even though	640
factors associated	639
blood pressure	638
cell death	635
positive results	626
sars virus	623
family members	622
outbreak associated	621
randomized controlled	620
respiratory illness	619
mg kg	619
clinical presentation	614
kidney injury	611
emerging infectious	610
lung tissue	610
probable bat	609
cytokine release	609
clinical samples	607
airborne transmission	604
disease progression	602
hydrogen bond	601
early stage	600
virus disease	600
within days	599
emergency department	597
potential therapeutic	596
rna synthesis	596
host immune	595
respiratory droplets	594
antiviral drug	592
binding energy	592
i interferon	591
acid residues	591
several studies	590
rna extraction	588
necrosis factor	587
influenza viruses	585
sars cases	584
virtual screening	584
coronavirus replication	583
reverse transcriptase	578
two groups	576
medical staff	576
time pcr	576
two patients	576
proinflammatory cytokines	576
patients may	575
ang ii	573
national health	571
sore throat	570
respiratory specimens	569
data analysis	569
oxidative stress	567
adverse events	567
multiple organ	566
approved drugs	565
years old	564
may lead	563
viral clearance	562
confirmed sars	558
common cold	558
patients admitted	557
open reading	556
clinical specimens	556
mortality rates	555
related coronavirus	555
highly pathogenic	554
clinically proven	553
clinical data	552
envelope protein	548
person transmission	548
pulmonary disease	547
case reports	547
phylogenetic analysis	547
lung cancer	546
competing interests	544
cell membrane	544
class i	543
human cells	543
human monoclonal	542
data collection	541
rheumatoid arthritis	540
adverse effects	538
pdb id	538
ace protein	537
cell receptor	537
entry depends	537
pcr assay	536
hospital admission	536
wide range	535
tract infections	535
negative results	535
critical care	534
ct values	533
median age	533
pandemic influenza	532
one patient	532
acute kidney	530
coronavirus outbreak	530
hand hygiene	530
data suggest	529
ng ml	528
stem cell	528
human airway	527
proven protease	526
viral pneumonia	525
south korea	525
myocardial injury	523
posted may	523
virus infections	522
ncov infection	521
liver injury	519
genome sequences	519
previously reported	518
dry cough	517
rhesus macaques	516
pediatric patients	515
infection prevention	515
inflammatory responses	514
also observed	514
mouse model	514
sequence alignment	513
widely used	513
severe patients	512
computed tomography	511
terminal domain	509
endoplasmic reticulum	508
patients hospitalized	508
respiratory virus	506
including sars	506
two different	505
tumor necrosis	505
mild symptoms	505
posted september	503
patients treated	503
symptomatic patients	500
neurological manifestations	500
diagnostic tests	500
mouse hepatitis	499
study showed	498
creative commons	498
protective immunity	496
also known	495
binding sites	494
statistical analysis	494
highly conserved	493
may cause	493
clinical practice	492
ace receptors	491
significant differences	489
swab samples	488
cardiac injury	488
china clinical	487
mesenchymal stem	485
zika virus	485
study clinical	481
one study	480
heart disease	479
airway epithelial	479
icu patients	478
posted august	477
positive sars	476
early stages	476
antiviral agents	476
results suggest	475
nlrp inflammasome	475
nucleic acids	475
different types	473
cov nsp	473
taken together	473
signaling pathway	472
septic shock	470
alveolar damage	468
family cluster	467
supplementary material	467
type diabetes	467
ct scan	466
icu admission	465
direct contact	465
antibody titers	464
growth factor	464
spectrum antiviral	464
samples collected	462
human lung	461
copies ml	460
oxygen saturation	459
blood samples	458
posted june	458
myocardial infarction	457
disease caused	457
los pacientes	456
em structure	456
receptor blockers	456
life cycle	456
multiple sclerosis	456
herpes simplex	455
results showed	455
tested negative	455
first step	454
also reported	454
virus type	454
protein interaction	452
york city	452
novel human	451
significantly lower	451
may play	451
drug administration	450
suspected covid	450
dengue virus	450
negative control	448
face masks	448
membrane protein	448
commonly used	446
endothelial cell	445
like receptor	444
animal model	443
current pandemic	441
protein expression	439
severe sars	438
lung disease	437
clinical management	436
may contribute	436
bone marrow	435
respiratory viral	435
viral spike	434
molecular weight	434
higher levels	433
per day	433
patients without	433
protein structure	433
cell fusion	432
kidney disease	432
pacientes con	431
respiratory diseases	430
real time	430
western blot	429
detect sars	429
receptor recognition	428
logistic regression	428
fusion protein	427
cell rna	426
infectious virus	426
rna genome	426
adult inpatients	425
pulmonary fibrosis	425
protein interactions	425
currently available	424
diffuse alveolar	424
reported cases	423
west nile	423
may provide	423
suspected cases	420
therapeutic options	419
severe illness	418
united kingdom	416
reproduction number	416
neurological symptoms	416
enveloped viruses	415
infect dis	415
adult patients	415
signaling pathways	415
time reverse	414
key role	414
igg antibody	414
release syndrome	414
treatment options	414
respiratory system	414
commercially available	413
urgent need	412
causative agent	412
nan doi	412
herd immunity	411
health commission	411
crucial role	410
dna vaccine	410
cell response	410
host response	409
virus transmission	409
highly expressed	408
atypical pneumonia	408
high viral	408
interim guidance	407
cov infections	406
virus particles	406
current study	405
patients receiving	404
situation report	403
human sars	403
coronavirus nucleocapsid	403
also showed	402
glass opacities	402
preventive measures	402
vaccine candidates	402
poor prognosis	402
positive cases	402
plasma therapy	401
chinese center	401
alveolar epithelial	400
patient care	400
study group	400
treat covid	400
md simulation	399
natural killer	399
health authorities	399
epidemiological characteristics	398
binding free	398
early phase	398
described previously	398
time points	398
human population	398
positive samples	397
specific antibody	397
million people	396
effective treatment	396
infectious bronchitis	396
high mortality	395
available data	395
cd cd	394
older adults	394
cov replication	394
antiviral therapy	393
infection may	393
age groups	393
molecular mechanisms	392
bronchoalveolar lavage	392
surgical masks	392
plasma membrane	392
chronic obstructive	391
isothermal amplification	391
viral protein	391
two weeks	391
three times	389
van der	389
secondary structure	388
simplex virus	388
clinical signs	388
lateral flow	388
accessory proteins	387
much higher	387
dipeptidyl peptidase	387
lymphocyte count	386
prospective study	386
sequence identity	385
emergency use	384
sars infection	384
nitric oxide	383
genomic rna	383
laboratory findings	382
virus origins	382
patients showed	381
posted july	381
acid sequence	380
viral diseases	379
traditional chinese	378
cytopathic effect	377
obstructive pulmonary	377
drug design	377
viral transmission	377
national institute	377
determine whether	376
sample collection	376
respiratory pathogens	376
tract infection	375
infected mice	375
surface area	375
viral envelope	375
familial cluster	375
many countries	374
index case	374
care units	374
positive control	374
cov rna	373
may help	373
serological tests	373
study design	372
potential role	371
guangdong province	371
intravenous immunoglobulin	371
ischemic stroke	371
study period	369
inhibitory activity	369
conformational changes	368
tissue distribution	368
high level	368
cells expressing	368
days post	368
bat sars	368
lactate dehydrogenase	367
ct findings	367
phase i	366
gold standard	366
flow cytometry	366
inflammatory syndrome	366
healthcare professionals	365
antibody tests	364
calculated using	364
community transmission	364
genome sequencing	364
kawasaki disease	363
health system	363
mass spectrometry	363
genomic characterisation	362
three patients	362
cardiovascular system	362
emerging coronaviruses	361
ethics committee	361
cytokine production	361
may result	361
inhibit sars	361
chinese medicine	360
critical role	360
southern china	360
acute phase	360
i ifn	360
asymptomatic cases	359
standard deviation	359
pcr tests	359
body temperature	358
mg dl	357
prefusion conformation	356
pcr assays	356
tissue damage	356
gastrointestinal tract	355
probable sars	355
en pacientes	355
sialic acid	355
white blood	354
bat coronavirus	354
vaccine candidate	353
pulmonary embolism	352
previous study	352
antiviral effects	352
machine learning	351
coronavirus rna	351
whole blood	351
mild disease	350
transgenic mice	350
thermo fisher	350
medical records	350
reading frame	349
early transmission	349
recently emerged	349
care facilities	348
nile virus	348
adipose tissue	348
specific igg	348
bronchitis virus	347
inflammatory cytokine	347
severe symptoms	347
mean age	347
nosocomial transmission	346
false negative	346
common symptoms	346
linked immunosorbent	346
small molecule	346
age group	346
ill covid	345
epithelial cell	345
confidence interval	345
lung pathology	345
disease transmission	344
small molecules	344
biorxiv doi	344
pathological findings	344
crystal structures	344
humoral immune	344
recovered patients	343
future studies	343
pcr results	343
md simulations	343
spike receptor	341
observational cohort	341
disease course	340
mild covid	339
asymptomatic carriers	339
antiviral treatment	339
therapeutic targets	339
endothelial dysfunction	338
clinical improvement	338
expression levels	338
blood cell	337
first time	337
cell cultures	337
positive test	335
data bank	335
pneumonia associated	334
protease tmprss	334
ace inhibitors	334
structural protein	334
protein data	334
relative humidity	333
coronavirus hku	333
better understand	332
disease outbreaks	332
first reported	332
infectious agents	332
multisystem inflammatory	332
cell type	331
treating covid	331
systemic inflammation	331
vaccine design	331
throat swab	330
lung damage	330
laboratory tests	330
oral transmission	330
cerebrospinal fluid	330
multiple sequence	330
diagnostic testing	330
analysis showed	329
induced lung	328
relatively low	327
elevated levels	327
remains unclear	327
statistical significance	326
antibody levels	326
therapeutic agents	326
macrophage activation	326
rapid spread	326
lung epithelial	326
angiotensinconverting enzyme	326
results indicate	326
controlled trials	326
effectively inhibit	325
university hospital	325
hiv aids	325
small number	324
laboratory testing	324
dis doi	324
expressing cells	323
organ dysfunction	323
force field	323
important lessons	323
infected people	323
infection rate	322
critical illness	322
liver disease	322
may occur	322
oxygen therapy	322
better understanding	322
complete genome	321
nonstructural proteins	321
ncov spike	321
higher mortality	321
new virus	321
coronavirus indicating	320
binding pocket	320
saliva samples	320
protein kinase	320
high affinity	319
findings suggest	319
will need	319
potential risk	319
lung cells	319
two cases	319
see table	319
drug candidates	319
angiotensin receptor	318
respiratory samples	318
binding protein	318
strand rna	318
less likely	317
kidney transplant	317
cardiovascular diseases	317
serological assays	317
human health	317
clinical outcome	317
vitro studies	317
coronavirus nl	316
hospitalized covid	316
influenza pandemic	316
patients received	315
coronavirus main	315
household contacts	315
throat swabs	314
mice infected	314
asymptomatic individuals	314
like particles	314
analyzed using	314
alveolar macrophages	314
inflammatory markers	312
mm nacl	312
venous thromboembolism	312
severe coronavirus	312
sequence analysis	311
patients presenting	311
case definition	311
well plates	311
may increase	310
coronavirus oc	310
mers coronavirus	310
face mask	310
disease outbreak	309
virus rna	309
early diagnosis	309
early detection	308
structural studies	305
clinical findings	305
severely ill	305
rna detection	305
antibody test	305
mononuclear cells	305
virus may	304
acquired pneumonia	304
one case	304
intravascular coagulation	304
cells infected	304
wuhan city	303
control study	303
drug development	303
fusion peptide	303
patient samples	302
extended data	302
blood group	302
health measures	302
ace binding	302
results obtained	302
antibody testing	301
observational studies	301
young children	301
human infection	301
antiviral response	301
inflammatory bowel	301
serum levels	300
drug targets	300
viral nucleic	300
rna sequencing	300
whole genome	300
ion channel	299
hydrogen bonding	299
rna replication	299
dependent enhancement	298
median time	298
hospital stay	298
en los	298
disseminated intravascular	298
ground glass	298
specific cd	297
study reported	297
immunosorbent assay	297
cell activation	297
literature review	297
open access	296
human tissues	296
immune cell	296
nipah virus	296
abdominal pain	296
positive rt	296
review board	296
surgical mask	295
nk cell	295
ace gene	295
rapid detection	294
hemorrhagic fever	294
different countries	294
health systems	294
weight loss	294
current covid	294
infect humans	293
new cases	293
inhibitory effect	292
vaccinia virus	292
north america	292
high prevalence	292
protective effect	291
evidence suggests	291
also used	291
medical center	291
like symptoms	291
international committee	290
cells via	290
institutional review	290
sequencing data	289
publicly available	289
relatively high	288
murine coronavirus	288
posted october	288
lessons learned	288
neurological complications	288
nonstructural protein	288
regression analysis	288
risk assessment	288
human angiotensin	288
positive result	288
therapeutic strategies	287
coronary artery	287
preliminary report	287
bat coronaviruses	287
broad spectrum	287
lung inflammation	287
low levels	287
infection among	287
infected person	287
mediated isothermal	286
mm tris	286
studies showed	286
analysis based	286
angiotensin i	285
seasonal influenza	285
high sensitivity	285
aldosterone system	285
asymptomatic infection	284
human proteins	284
healthcare settings	284
significantly reduced	284
serum antibody	283
first cases	283
adaptive immunity	283
negative pressure	283
false positive	282
cellular immune	282
phylogenetic tree	282
influenza infection	282
days later	282
class ii	282
least two	282
therapeutic target	281
may affect	281
study found	281
indicating person	281
hydrophobic interactions	281
lung tissues	281
side chain	280
highly contagious	280
neutralization assay	280
human cell	279
attack rate	279
general public	279
novel virus	279
previous reports	279
cleavage sites	279
three different	278
recently published	278
current knowledge	278
antiviral effect	278
acid detection	278
medical history	277
cov genome	277
emerged novel	277
reading frames	277
viral respiratory	277
transmissible gastroenteritis	277
study also	277
accepted article	277
viral spread	277
tissue culture	276
scientific community	276
first week	275
natural products	275
health workers	275
igm antibodies	275
chloroquine effectively	275
springer nature	275
animal species	275
understanding sars	275
fda approved	275
mainland china	274
current evidence	274
small intestine	274
associated pneumonia	274
healthy individuals	273
hydrogen peroxide	273
increased levels	273
like receptors	273
novel sars	273
high expression	273
sectional study	272
will also	272
transmission potential	271
neurologic manifestations	271
might also	271
lymph nodes	271
se recomienda	271
autoimmune diseases	271
interferon beta	271
medical care	271
oropharyngeal swabs	270
lung function	270
sense rna	270
analysis revealed	270
positive rate	270
asymptomatic infections	270
proteolytic cleavage	269
lamp assay	269
healthy controls	269
clinical evidence	269
mild cases	269
human igg	269
invasive ventilation	268
ct value	268
cellular receptor	268
systematic reviews	268
physical distancing	268
disease onset	268
cell count	267
protein sequence	267
coronavirus nsp	267
care providers	267
swab specimens	267
escherichia coli	267
viral genomes	267
ii receptor	267
infection risk	267
like sars	267
therapeutic efficacy	267
blood cells	267
written informed	266
case study	266
sars pathogenesis	266
urgently needed	266
transcription factor	266
pp ab	265
test result	265
older age	265
bovine serum	265
blood donors	265
chronic kidney	265
coronavirus pandemic	265
related coronaviruses	265
jurisdictional claims	264
use authorization	264
commons attribution	264
published maps	264
remains neutral	264
supportive care	264
nature remains	264
institutional affiliations	264
like coronavirus	263
also shown	263
phase iii	263
pg ml	262
asymptomatic sars	262
intermediate hosts	262
antibody detection	262
significantly increased	261
illness onset	261
cov pl	261
statistical analyses	261
single cell	261
wild type	261
continuous variables	261
transcription polymerase	260
cycle threshold	260
fatality rates	260
cruise ship	260
interquartile range	260
term care	260
genetic diversity	259
elderly patients	259
seafood market	259
transmembrane serine	259
der waals	259
total rna	259
old man	258
coronavirus genome	258
results show	258
dependent manner	258
diagnostic test	258
pathogenic coronaviruses	258
may explain	258
twice daily	258
protein structures	258
invasive mechanical	258
disease patients	257
palm civets	257
social media	257
categorical variables	257
clinical diagnosis	257
molecular biology	257
many patients	257
intermediate host	257
generated using	256
will help	256
hiv infection	256
staff members	256
infection rates	256
inflammatory mediators	255
healthcare system	255
march th	255
vascular endothelial	254
compassionate use	254
stool samples	254
significantly associated	254
soluble ace	254
cerebrovascular disease	254
respiratory secretions	254
laboratory diagnosis	254
human metapneumovirus	254
wild animals	254
lupus erythematosus	254
fisher scientific	253
syndrome associated	253
surface stability	253
medicinal plants	253
nasal cannula	252
health crisis	252
generating procedures	252
renal failure	252
potential inhibitors	252
aged years	251
epi isl	251
healthcare systems	251
similar results	251
clinical progression	251
reproductive number	251
bowel disease	251
significantly different	251
mammalian cells	250
four patients	250
smooth muscle	250
care settings	250
negative controls	250
genomic characterization	250
international concern	250
human disease	249
protein binding	249
blood vessels	249
northern italy	249
magnetic resonance	249
combination therapy	249
testing positive	248
mutation rate	248
chronic diseases	248
autodock vina	248
well known	248
environmental factors	248
global public	247
horseshoe bats	247
first two	247
aerosol transmission	247
mhc class	247
healthy donors	247
exact test	247
staphylococcus aureus	247
cl protease	247
prospective cohort	246
long term	246
rapidly spread	246
potential drug	246
immune function	246
note springer	246
protein sequences	245
neutralizing activity	245
interstitial pneumonia	245
prostate cancer	245
organ damage	244
european countries	244
dynamics simulations	244
operating room	244
medical conditions	244
chloroquine phosphate	243
confirmed case	243
disease prevention	243
studies suggest	243
coronavirus receptor	243
respiratory rate	243
complement activation	242
less severe	242
higher viral	242
cell subsets	242
phase ii	242
thrombotic complications	242
con covid	242
recently reported	242
dimer levels	242
corticosteroid treatment	242
among children	242
olfactory bulb	242
small sample	241
potential treatment	241
eye protection	241
epidemiological data	241
virus spread	241
inclusion criteria	241
acid sequences	241
data indicate	240
cov plpro	240
ct imaging	240
respiratory coronavirus	239
recent report	239
cancer cells	239
antiviral activities	239
asymptomatic carrier	239
mrna expression	239
income countries	239
older patients	239
differentially expressed	239
highly infectious	239
data sets	238
nsp protein	238
predictive value	238
por sars	238
patients undergoing	238
viral antigens	238
critical covid	238
bat species	238
main proteinase	238
systemic lupus	238
working group	237
much lower	237
coronavirus entry	237
entry receptor	237
patients requiring	237
retrospective analysis	236
artificial intelligence	236
like coronaviruses	236
clinical study	236
time point	236
spread rapidly	235
treatment strategies	235
breast cancer	235
deceased patients	235
low viral	235
new insights	235
vitro antiviral	235
cov may	235
based drug	235
biosafety level	234
activation syndrome	234
acid test	234
normal range	234
bronchial epithelial	234
coronavirus envelope	234
based vaccine	234
brain barrier	234
health services	233
included studies	233
seq data	233
transmission routes	233
serological testing	233
virological assessment	233
cell proliferation	233
among different	233
transport medium	233
posted april	232
syndrome virus	232
death rate	232
whether sars	232
developing countries	232
ocular surface	232
therapeutic potential	232
major outbreak	232
mouse models	232
ct scans	231
data set	231
vast majority	231
confidence intervals	231
supplemental oxygen	231
suspected sars	231
cell immunity	230
recombinant sars	230
hospital mortality	230
acid amplification	230
species transmission	230
infected persons	229
cause severe	229
coronaviridae family	229
highly sensitive	228
host factors	228
humoral immunity	228
adults hospitalized	228
like proteinase	228
several limitations	228
coronavirus papain	228
studies reported	227
transcription factors	227
study conducted	227
possible cause	227
sars patient	227
neutrophil extracellular	227
dromedary camels	227
convalescent patients	227
severe infection	227
cov infected	227
tissue factor	226
significant increase	226
live attenuated	226
basic reproduction	226
odds ratio	226
reference genome	226
recent reports	225
gi symptoms	225
health concern	225
recombinant human	225
transmembrane domain	225
comparative analysis	225
goat anti	224
first days	224
related viruses	224
primary care	224
reactive oxygen	224
storm syndromes	224
blood mononuclear	224
pilot study	223
influenza vaccine	223
fold higher	223
will provide	223
additional file	223
secondary infections	223
enzymatic activity	222
lysis buffer	222
african green	222
healthcare personnel	222
human host	222
air pollution	222
recombinant protein	221
post infection	221
infected vero	221
protective role	221
porcine epidemic	221
emerging viruses	221
neonates born	220
transfected cells	220
specimen collection	220
live virus	220
host proteins	220
clinical research	220
posted november	220
cellular entry	220
among others	220
chest radiograph	220
body fluids	220
effective vaccine	220
clinical presentations	219
infected cases	219
nasal swabs	219
determined using	219
health professionals	219
convalescent sera	219
dendritic cell	218
coronavirus diseases	218
extracellular traps	218
liver function	218
among health	218
human body	218
close proximity	218
platelet count	218
quality control	218
patients suffering	218
transmembrane protease	218
systemic inflammatory	218
enzyme inhibitors	218
sequence similarity	218
following sars	217
lavage fluid	217
immune evasion	217
deep learning	217
travel history	216
human protein	216
viral disease	216
single center	216
based vaccines	216
viral fusion	216
diagnostic accuracy	215
cell infection	215
antibody production	215
inactive inactive	215
feline infectious	215
binding affinities	215
med doi	215
coronavirus vaccine	214
structural analysis	214
viral pathogens	214
oxygen species	213
respiratory support	213
primary human	213
diamond princess	213
financial support	213
infectious peritonitis	213
accession number	213
genetic material	213
sequence data	213
orf protein	213
cell cycle	212
moderate covid	212
consider cytokine	212
community outbreak	212
breast milk	212
generation sequencing	212
direct viral	211
like disease	211
analysis using	211
likely due	211
potent inhibitor	211
immune activation	211
culture medium	211
binding domains	210
cell therapy	210
host receptor	210
increased mortality	210
ic values	209
two decades	209
cysteine protease	209
times higher	208
also identified	208
final concentration	208
genomic sequences	208
unclear whether	207
species severe	207
inflammatory diseases	207
copy number	207
clinical efficacy	206
codon usage	206
viral titers	206
cases reported	206
inactivated sars	206
adverse outcomes	206
hospital discharge	206
pulmonary edema	206
negative rt	206
time period	206
furin cleavage	206
ex vivo	205
membrane oxygenation	205
available online	205
qt interval	205
affected patients	205
within hours	205
two distinct	205
many studies	205
antibody titer	205
imaging features	205
maximum likelihood	205
mg day	205
docking studies	205
pcr positive	204
underlying diseases	204
pandemic caused	204
host defense	204
glass opacity	204
among covid	204
viral transport	204
potential drugs	204
beneficial effects	204
wuhan clinical	204
develop severe	204
data regarding	204
cov virus	204
memory cd	204
transcriptase polymerase	203
ct images	203
length human	203
among healthcare	203
fusion proteins	203
available evidence	203
decision making	202
high rate	202
family coronaviridae	202
transplant patients	202
dna vaccines	202
patients diagnosed	202
pneumonia cases	202
well plate	202
epidemic diarrhea	202
cell membranes	202
disease covid	202
immune dysregulation	202
will require	201
may represent	201
clinical use	201
corticosteroid therapy	201
three days	201
probable cases	201
negative samples	201
drug target	201
human cases	201
studies using	200
patients affected	200
mildly symptomatic	200
fecal samples	200
immunocompromised patients	200
severe lung	200
five patients	200
two studies	200
severely affected	200
binding energies	200
prolonged viral	200
virus detection	200
target cell	200
tcid ml	199
increasing number	199
human primates	199
pathogenic human	199
mg twice	199
extracorporeal membrane	199
reference sequence	199
st century	199
creatine kinase	199
short period	198
significant reduction	198
yellow fever	198
renal function	198
epidemiological studies	198
also detected	198
hand washing	198
household members	198
study population	198
host innate	198
negative test	198
hospital staff	198
ongoing clinical	198
six patients	198
baseline characteristics	197
single nucleotide	197
flow nasal	197
para el	197
pulmonary function	197
retrospective case	197
barr virus	197
endotracheal intubation	197
coronavirus family	197
emerging human	196
molecular modeling	196
cytokine storms	196
cell epitope	196
acute myocardial	196
outcomes among	196
safety profile	196
replacement therapy	196
per well	195
effective antiviral	195
bacterial infection	195
infected cell	195
narrative review	195
water molecules	195
influenza vaccination	195
also important	195
host range	195
least days	195
health interventions	195
randomised controlled	195
high throughput	195
old male	195
genomic sequence	194
health literacy	194
severe clinical	194
differential diagnosis	194
previously published	194
sars pneumonia	194
infections among	193
pregnant patients	193
master mix	193
protein levels	193
task force	193
short time	193
transplant recipient	193
body weight	193
national institutes	193
igg levels	193
nursing homes	193
limited number	193
nasal cavity	193
san diego	193
inflammasome activation	192
supporting information	192
patients presented	192
older people	192
airway epithelia	192
precautionary measures	192
like illness	192
dna polymerase	192
copies per	192
low risk	192
critical cases	192
heptad repeat	192
sars transmission	192
like virus	192
complement system	191
membrane vesicles	191
graphpad prism	191
days prior	191
sars cl	191
rna binding	190
diarrhea virus	190
web server	190
million cases	190
based assay	190
nucleotide sequence	190
index patient	190
drug interactions	190
mechanisms underlying	190
viral membrane	190
may serve	190
three cases	190
will likely	190
viral attachment	190
linear regression	190
corresponding author	190
washington state	190
medical personnel	190
distancing measures	189
health behaviors	189
barre syndrome	189
docking study	189
olfactory epithelium	189
induced acute	189
potential target	189
general hospital	189
nucleocapsid proteins	189
alveolar cells	188
inflammatory effects	188
label non	188
detection rate	188
physical examination	188
also demonstrated	188
type iii	188
cumulative number	188
plasminogen activator	188
broad range	188
plasma samples	187
cells may	187
may reduce	187
therapeutic strategy	187
parainfluenza virus	187
modelling study	187
essential role	187
protein complex	187
western blotting	187
detecting sars	187
potent neutralizing	187
recent advances	187
animal studies	187
cystic fibrosis	187
network analysis	187
newly identified	187
possible role	187
new disease	187
patients will	187
radiological findings	187
pneumonia caused	187
protective measures	187
rbd protein	187
transmission rate	186
relatively small	186
protective effects	186
viral infectivity	186
artery disease	186
fatal cases	186
healthcare providers	186
two major	186
associated sars	186
express ace	186
ncov pneumonia	186
high degree	186
large numbers	186
situ hybridization	186
anal swabs	185
recent years	185
human covs	185
umbilical cord	185
ibd patients	185
applied biosystems	185
proteolytic processing	185
infected individual	185
multiorgan failure	185
viral life	185
new human	185
coronavirus covid	185
left ventricular	185
virus genome	184
inhibitory effects	184
solid organ	184
replication cycle	184
clinical disease	184
healthy adults	184
one hand	184
target protein	184
inflammatory drugs	184
care system	184
two days	184
critical patients	184
highly specific	184
wide variety	184
rbd domain	184
treated patients	183
ace activity	183
disease pathogenesis	183
european society	183
day post	183
virus neutralization	183
three groups	183
among sars	183
receptor antagonist	183
therapeutic option	183
first identified	183
mortality due	183
cov rbd	183
killer cells	183
targeting sars	182
ace levels	182
chest radiographs	182
limited data	182
binding motif	182
false positives	182
environmental conditions	182
protein synthesis	182
clinical benefit	182
table shows	182
deaths worldwide	182
stimulating factor	182
emergency response	182
also tested	181
based study	181
con el	181
clinical severity	181
chest pain	181
future research	181
high fever	181
different cell	181
au ml	181
vitro activity	181
buffered saline	181
regression model	181
death toll	181
serially diluted	181
molecular mechanism	180
domain complexed	180
th day	180
id now	180
expression level	180
young adults	180
medical treatment	180
long time	180
atrial fibrillation	180
drug repositioning	180
based assays	180
lymphocyte counts	180
long structural	180
april th	180
worth noting	180
hla class	180
vesicular stomatitis	180
social isolation	179
still unclear	179
coagulation parameters	179
viral pathogenesis	179
side chains	179
igm igg	179
new england	179
transport media	179
health officials	179
humoral response	179
major role	179
lung diseases	179
time course	178
murine hepatitis	178
extracellular vesicles	178
article distributed	178
also associated	178
room air	178
oropharyngeal swab	178
chronic hepatitis	178
novel severe	178
sex differences	178
information regarding	178
cumulative incidence	178
organ transplant	178
emerging infections	178
sequence homology	178
study using	177
inflammatory cells	177
authors contributed	177
hiv protease	177
patients developed	177
clinically approved	177
blood glucose	177
coronavirus isolated	177
cohort studies	177
different regions	177
contact history	177
severe forms	177
nuclear factor	177
membrane proteins	177
will continue	177
remains unknown	177
imaging findings	176
higher affinity	176
inhibitors targeting	176
lymphocyte subsets	176
high incidence	176
patients compared	176
potential targets	176
throughput screening	176
essential oils	176
one week	176
large scale	176
acid testing	176
increased expression	176
data available	176
mild respiratory	176
quantitative rt	175
assessed using	175
diabetic patients	175
like proteases	175
se ha	175
cov entry	175
heart rate	175
del paciente	175
molecule inhibitors	175
interferon response	175
chest computed	175
showed significant	175
ii pneumocytes	175
environmental contamination	174
also present	174
human serum	174
infectious sars	174
affected countries	174
expression vector	174
study demonstrated	174
health response	174
emerging viral	174
data collected	174
cov outbreak	174
pathogenic coronavirus	174
preliminary results	174
measured using	173
south africa	173
first report	173
access article	173
old woman	173
antiviral agent	173
associated case	173
posterior oropharyngeal	173
retrospective review	173
although sars	173
lung fibrosis	173
several countries	173
covid patients	173
differential expression	173
cytokine levels	173
specific igm	173
bacterial infections	173
blot analysis	172
dynamics simulation	172
mediated immunity	172
fold increase	172
current status	172
el uso	172
sars vaccine	172
day mortality	172
abnormal coagulation	172
flow rate	171
patients recovered	171
cell lysates	171
analytical sensitivity	171
infected patient	171
ge healthcare	171
global spread	171
ncov infected	171
surface glycoprotein	171
nasal swab	171
ifn response	171
psychological distress	171
human immune	171
muscle cells	171
many cases	171
lower risk	171
chest radiography	171
virus load	171
subunit vaccine	171
become infected	171
symptoms onset	170
virus shedding	170
million confirmed	170
virus titers	170
target proteins	170
airway epithelium	170
health status	170
face shield	170
nucleotide sequences	170
secondary antibody	169
natural reservoirs	169
case definitions	169
ligand binding	169
newly discovered	169
study protocol	169
tmprss expression	169
cell counts	169
molecular testing	169
near future	169
plasma levels	168
asymptomatic contact	168
por covid	168
obtained using	168
mortality among	168
ifn production	168
standard care	168
liver transplant	168
chinese horseshoe	168
serial dilutions	168
stomatitis virus	168
bat cov	168
cellular immunity	168
independent risk	168
antiviral compounds	168
receptor usage	167
signal transduction	167
pattern recognition	167
higher rates	167
final manuscript	167
i interferons	167
substrate binding	167
physical activity	167
submitted work	167
oropharyngeal saliva	167
viral antigen	167
therapeutic interventions	167
nsp nsp	167
enrichment analysis	167
full text	166
significant role	166
fever virus	166
clinical picture	166
financial relationships	166
drug resistance	166
nonhuman primates	166
gastroenteritis virus	166
serological assay	166
psychological impact	166
inactivated vaccine	166
igg igm	166
genetic variants	166
expression profiling	166
include fever	166
unknown etiology	165
princess cruise	165
positive cells	165
two consecutive	165
current sars	165
vaccine construct	165
cov clpro	165
higher level	165
case patient	165
patients also	165
different stages	165
multiplex pcr	165
original author	165
sodium hypochlorite	165
reported symptoms	165
causes severe	165
drug treatment	165
ongoing pandemic	165
control strategies	164
syndrome clinical	164
takes place	164
cd cells	164
rapid test	164
protein complexes	164
gel electrophoresis	164
testing capacity	164
negative sars	164
neuroinvasive potential	164
por el	164
potential antiviral	164
second week	164
spike glycoproteins	164
different species	163
palm civet	163
rhesus macaque	163
naturally occurring	163
encephalitis virus	163
clinical application	163
potential conflict	163
randomized trial	163
heparan sulfate	163
full length	163
confirmed patients	163
asymptomatic covid	163
th cells	163
secondary cases	162
viruses including	162
cardiovascular complications	162
based approach	162
results indicated	162
etiological agent	162
false negatives	162
molecular patterns	162
associated molecular	162
rapid review	162
promising results	162
local transmission	162
functional characterization	162
research team	162
skeletal muscle	162
insulin resistance	162
thank dr	162
ace cells	161
healthy volunteers	161
kg day	161
virus strain	161
lower levels	161
infectious agent	161
pathogenic viruses	161
vital signs	161
since sars	161
root mean	160
american college	160
molecular basis	160
transmission route	160
diagnostic methods	160
china covid	160
worse outcomes	160
nursing home	160
patients died	160
two independent	159
studies will	159
acute cardiac	159
probe sets	159
positive pcr	159
future outbreaks	159
also included	159
veroe cells	159
pcr products	159
human populations	159
negative result	159
may require	159
mice immunized	159
disease spread	159
pao fio	159
clinical laboratory	159
face shields	158
identify potential	158
mean square	158
recent insights	158
genbank accession	158
fetal bovine	158
digestive system	158
el paciente	158
prothrombin time	158
bcg vaccination	158
much less	158
vascular permeability	158
alanine aminotransferase	158
medical research	158
using different	158
ace complex	158
consensus statement	158
patients reported	158
cell viability	158
may need	157
negatively charged	157
cytopathic effects	157
clinical manifestation	157
genome replication	157
gastrointestinal manifestations	157
approved drug	157
recognition receptors	157
ethical approval	157
international health	157
per million	157
treatment protocol	157
protease activity	157
human influenza	157
reverse genetics	157
receptor expression	157
advanced age	157
may induce	157
human subjects	156
th march	156
population density	156
old female	156
genetic recombination	156
stromal cells	156
clinical evaluation	156
supplementary information	156
inhibiting sars	156
health conditions	156
rna dependent	156
acute infection	156
pcr amplification	155
may act	155
spread worldwide	155
included patients	155
specific treatment	155
severe pulmonary	155
mini kit	155
therapeutic intervention	155
ucsf chimera	155
supplementary materials	155
proximal origin	154
acute renal	154
patients tested	154
greater risk	154
health organisation	154
secondary infection	154
test positive	154
local health	154
using human	154
serum albumin	154
ace mrna	154
well established	154
therapeutic approaches	154
virus strains	153
high number	153
multicenter study	153
system inhibitors	153
may reflect	153
male sex	153
positivity rate	153
virus clearance	153
liver enzymes	153
assay using	153
glycosylation sites	153
infants born	153
cytoplasmic tail	153
different human	153
mass index	153
literature search	153
protein may	152
viruses related	152
specific antiviral	152
pivotal role	152
different time	152
considered statistically	152
receptor signaling	152
antiphospholipid antibodies	152
conformational change	152
nasal epithelial	152
mitigation strategies	152
associated acute	152
virus isolation	152
spread across	152
ec values	152
care facility	152
infections caused	151
aspartate aminotransferase	151
data show	151
healthcare facilities	151
cell receptors	151
two main	151
scientific evidence	151
lung failure	151
low level	151
primer probe	151
genome structure	151
binding proteins	151
stimulated gene	151
human infections	151
highly potent	151
severe influenza	151
higher rate	151
conducted using	151
since december	151
risk patients	150
existing drugs	150
take place	150
stress disorder	150
second wave	150
pulmonary inflammation	150
immune systems	150
terminal region	150
huanan seafood	150
arterial hypertension	150
done using	150
science foundation	150
ncov sars	150
novel therapeutic	150
induced apoptosis	150
cov orf	150
clinical information	150
least three	150
term outcomes	150
high dose	150
personal protection	150
johns hopkins	150
nonhuman primate	150
cell function	150
chest imaging	150
coronavirus study	149
isolation ward	149
expressed genes	149
high specificity	149
study covid	149
commons licence	149
particularly important	149
detection limit	149
pcr detection	149
domestic animals	149
carrier transmission	149
subcellular localization	149
different populations	149
detected using	149
chemoattractant protein	149
first line	149
health threat	149
rhesus monkeys	149
intrauterine vertical	149
experimental data	149
expression data	149
inhibit viral	148
previous sars	148
across different	148
exclusion criteria	148
studies show	148
diagnostic assays	148
cells using	148
sars survivors	148
may th	148
severe critical	148
health service	147
also performed	147
preliminary data	147
samples obtained	147
convalescent individuals	147
toronto area	147
surveillance system	147
positively charged	147
igm antibody	147
vivo studies	147
nosocomial infection	147
laboratory data	147
expression patterns	147
disease clinical	147
tertiary care	147
developed symptoms	147
also suggested	147
still unknown	147
storm syndrome	147
chinese government	147
imported cases	147
highly effective	147
protein induces	146
prevent sars	146
several days	146
epidemiological features	146
body mass	146
mediated immune	146
potent antiviral	146
antigen presentation	146
natural history	146
healthcare worker	146
people worldwide	146
np swab	146
blood flow	146
following infection	146
causing severe	146
published studies	146
step rt	146
central role	145
human neutralizing	145
clinical laboratories	145
care systems	145
south america	145
rapidly evolving	145
droplet transmission	145
symptomatic covid	145
cutaneous manifestations	145
supplementary data	145
tissue samples	144
plasmid dna	144
risk groups	144
cord blood	144
thromboembolic events	144
candidate vaccines	144
potent inhibitors	144
taste disorders	144
monocyte chemoattractant	144
computational methods	144
hypercoagulable state	144
published data	144
drug delivery	144
olfactory dysfunction	144
among people	144
first day	144
symptomatic individuals	144
several factors	144
host interactions	144
ongoing covid	144
accessory protein	144
virus vaccine	143
necrotizing encephalopathy	143
rapid diagnosis	143
digestive tract	143
nine pregnant	143
oral mucosa	143
several clinical	143
antiviral immunity	143
data obtained	143
significant impact	143
ace may	143
potential use	143
malayan pangolins	143
samples tested	143
coronavirus epidemic	142
family member	142
environmental surfaces	142
amniotic fluid	142
global initiative	142
host species	142
among hospitalized	142
past years	142
antiviral responses	142
years ago	142
effective vaccines	142
viral particle	142
novel coronaviruses	142
droplet nuclei	142
temporal profiles	142
surface plasmon	142
poor outcomes	142
high proportion	142
ace interaction	142
overall mortality	142
moderate coronavirus	142
different clinical	142
communicable diseases	142
many viruses	142
metabolic syndrome	142
important roles	142
fusion core	141
cells transfected	141
using molecular	141
coronavirus nonstructural	141
competing financial	141
two viruses	141
greater toronto	141
online version	141
human bronchial	141
binding mode	141
review article	141
risk group	141
serum creatinine	141
cov strains	141
immunofluorescence assay	141
lung involvement	141
ischaemic stroke	141
per minute	141
infection caused	141
will allow	141
mouse igg	141
presumed asymptomatic	141
performance characteristics	141
human cov	141
human beings	140
molecular evolution	140
pulmonary vascular	140
containment measures	140
psychiatric disorders	140
well tolerated	140
viral activity	140
infection causes	140
asian countries	140
thrombotic events	140
another important	140
patients clinical	140
natural reservoir	140
rapid development	140
alveolar type	140
highest number	140
inflammatory factors	140
cov antibody	139
molecular detection	139
positively correlated	139
liver damage	139
shed light	139
catalytic activity	139
also called	139
allowed us	139
severe outcomes	139
new zealand	139
care testing	139
cov proteins	139
test performance	139
proinflammatory cytokine	139
electrostatic interactions	139
system involvement	139
newly emerging	139
primary outcome	139
mice transgenic	139
one month	139
using rt	139
readily available	139
sars case	139
lesser extent	139
pulmonary pathology	138
increased susceptibility	138
subunit vaccines	138
one day	138
mycobacterium tuberculosis	138
phase trial	138
higher proportion	138
average age	138
rdrp gene	138
cultured cells	138
less common	138
comparative study	138
kj mol	138
supplemental table	138
hospitalised patients	138
treating patients	138
spinal cord	138
infected animals	138
replication complex	138
novel corona	138
genetic analysis	138
serial interval	138