trigram

This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

trigram	frequency
severe acute respiratory	17807
acute respiratory syndrome	17294
respiratory syndrome coronavirus	10651
in patients with	8223
as well as	6848
patients with covid	6426
of the sars	5405
of severe acute	5093
the use of	4640
the presence of	4305
the number of	4057
middle east respiratory	3944
east respiratory syndrome	3943
a license to	3858
to display the	3851
medrxiv a license	3841
display the preprint	3841
granted medrxiv a	3841
license to display	3841
the preprint in	3840
who has granted	3831
has granted medrxiv	3831
of the virus	3814
the author funder	3698
is the author	3612
the copyright holder	3581
the treatment of	3545
holder for this	3524
copyright holder for	3524
of patients with	3448
of novel coronavirus	3361
due to the	3345
preprint in perpetuity	3248
this version posted	3194
the risk of	3118
based on the	3070
in this study	3038
one of the	3026
the development of	2885
in order to	2851
a novel coronavirus	2814
world health organization	2806
clinical characteristics of	2767
patients with severe	2758
respiratory distress syndrome	2732
for this preprint	2725
according to the	2669
acute respiratory distress	2632
which was not	2576
the novel coronavirus	2571
of the disease	2543
by peer review	2397
certified by peer	2396
was not certified	2394
not certified by	2394
the role of	2358
in addition to	2329
of coronavirus disease	2320
this preprint this	2291
preprint this version	2291
all rights reserved	2131
for the treatment	2081
a total of	2073
it has been	2038
patients infected with	2031
the severe acute	2025
the united states	1981
with severe acute	1961
a systematic review	1941
infected with sars	1902
the spread of	1900
is made available	1898
it is made	1895
with novel coronavirus	1888
available under a	1888
made available under	1887
license it is	1853
international license it	1852
patients with sars	1850
treatment of covid	1850
the absence of	1822
the s protein	1783
is associated with	1771
p r e	1764
associated with the	1761
p r o	1760
l p r	1760
a l p	1759
o u r	1756
n a l	1756
r n a	1756
u r n	1755
detection of sars	1755
j o u	1755
o o f	1754
r o o	1753
during the covid	1742
the spike protein	1734
the time of	1728
novel coronavirus in	1717
of the covid	1708
in hong kong	1693
a is the	1684
found to be	1679
hospitalized patients with	1649
under a is	1638
associated with a	1630
structure of the	1596
the impact of	1580
been shown to	1580
transmission of sars	1554
cd t cells	1546
there is no	1532
at the time	1529
in the united	1526
the effect of	1513
was used to	1510
there is a	1504
clinical features of	1501
with coronavirus disease	1500
the expression of	1500
analysis of the	1483
of the patients	1477
critically ill patients	1469
the detection of	1452
of a novel	1441
of patients infected	1417
related to the	1400
for disease control	1399
on the other	1397
the world health	1397
have been reported	1395
in the treatment	1388
the sars coronavirus	1386
such as the	1384
of the viral	1368
the context of	1366
pneumonia in wuhan	1359
role in the	1354
of sars coronavirus	1349
in terms of	1347
has been reported	1346
control and prevention	1342
from patients with	1328
the onset of	1327
in the absence	1323
a number of	1320
the case of	1315
the majority of	1314
risk factors for	1313
in the context	1298
compared to the	1292
the other hand	1290
this article is	1283
disease control and	1273
polymerase chain reaction	1265
novel coronavirus pneumonia	1262
has been shown	1258
most of the	1252
of the s	1251
intensive care unit	1249
the severity of	1232
the possibility of	1231
with severe covid	1224
the importance of	1205
for patients with	1184
the course of	1181
the fact that	1178
the most common	1176
a new coronavirus	1174
systematic review and	1168
as shown in	1167
in the case	1162
the immune system	1157
of hospitalized patients	1157
of the novel	1156
the coronavirus disease	1143
protein of sars	1137
the need for	1129
to be a	1129
cov and mers	1122
the end of	1121
need to be	1121
as a result	1120
well as the	1116
we found that	1116
reuse allowed without	1105
allowed without permission	1105
no reuse allowed	1105
novel coronavirus from	1103
personal protective equipment	1098
patients with coronavirus	1090
involved in the	1089
can be used	1088
health care workers	1087
the results of	1085
vero e cells	1085
spread of the	1080
positive for sars	1078
sars and mers	1074
to determine the	1074
the management of	1066
part of the	1065
in the presence	1057
the lack of	1057
the host cell	1052
of the coronavirus	1049
the production of	1044
was found to	1035
cov and sars	1034
review and meta	1023
more likely to	1015
is protected by	1014
article is protected	1013
protected by copyright	1013
the pathogenesis of	1013
in response to	1011
of the spike	1010
coronavirus disease in	1007
in the lungs	1005
the effects of	1001
cases of covid	1001
ace and tmprss	998
viral load in	993
disease in china	986
to the sars	980
features of patients	974
likely to be	972
has also been	962
the authors declare	960
prevention and control	957
it is important	956
respiratory syncytial virus	953
a variety of	950
a patient with	948
is important to	948
caused by the	947
of the pandemic	947
some of the	947
onset of symptoms	935
infected with novel	932
there was no	929
the efficacy of	915
and treatment of	914
included in the	913
be used to	913
in our study	911
in the same	909
angiotensin converting enzyme	906
the outbreak of	901
showed that the	900
responsible for the	900
s and s	899
shown in figure	898
coronavirus associated with	895
the prevalence of	893
to be the	892
the sars outbreak	885
in the early	885
was associated with	883
increased risk of	883
associated with severe	880
conflict of interest	880
shown to be	875
in the sars	875
patients in the	875
to reduce the	872
has not been	872
expression of ace	872
of cases of	869
are associated with	869
to evaluate the	868
the general population	866
because of the	865
of middle east	860
ill patients with	859
lower respiratory tract	859
the present study	858
in the lung	856
of viral rna	856
in the first	855
dependent rna polymerase	852
were found to	848
in the study	847
coronavirus spike protein	845
coronavirus in wuhan	843
acute lung injury	840
for the detection	840
understanding of the	835
of the most	834
the emergence of	833
for the sars	831
at room temperature	831
novel coronavirus disease	829
of the first	827
the level of	827
the respiratory tract	826
patients with pneumonia	826
with pneumonia in	825
it is not	821
this study was	818
the diagnosis of	816
to assess the	812
retrospective cohort study	811
have shown that	809
activation of the	808
during the sars	806
and clinical characteristics	803
patients with novel	798
in the s	798
influenza a virus	798
for this this	797
this this version	797
be associated with	794
with acute respiratory	793
in combination with	793
the formation of	791
are shown in	786
upper respiratory tract	785
the immune response	785
respiratory syndrome in	785
a review of	783
of this study	779
a and b	775
were used to	764
a result of	762
syndrome coronavirus infection	759
used for the	757
clinical course and	756
at the same	756
been reported in	755
centers for disease	754
central nervous system	754
found that the	752
of the study	751
tested positive for	751
a role in	751
an important role	750
the ace receptor	746
that can be	740
the active site	740
around the world	738
used in the	736
with a new	735
an increase in	735
in the present	734
in vitro and	733
of the human	733
should be considered	732
as a potential	730
diagnosis of covid	729
the basis of	729
morbidity and mortality	724
a recent study	721
with respect to	721
the identification of	718
large number of	715
of the severe	713
a retrospective cohort	711
it is possible	711
to understand the	711
epidemiological and clinical	710
associated with covid	709
high levels of	709
shortness of breath	709
crystal structure of	709
found in the	708
and outcomes of	706
used as a	706
functional receptor for	705
immune response to	704
the binding of	702
in critically ill	700
to that of	699
an outbreak of	698
a combination of	698
as compared to	697
of the immune	696
observed in the	696
was used for	695
of the epidemic	694
is one of	694
it is also	692
spread of sars	692
the surface of	690
review of the	690
human immunodeficiency virus	689
end of the	688
the middle east	688
there are no	688
caused by sars	688
the incubation period	687
of the infection	685
response to the	684
that of the	684
of the outbreak	683
and in the	682
diagnosis and treatment	681
been reported to	681
to have a	680
was performed using	680
important role in	678
the proportion of	678
associated with sars	678
identification of a	677
shown in fig	676
consistent with the	675
present in the	675
appears to be	674
in severe covid	673
may not be	673
of severe covid	672
was detected in	672
response to sars	670
between the two	668
the activation of	668
needs to be	667
the ability to	666
pneumonia in china	665
a series of	664
in accordance with	659
the s subunit	659
the same time	656
the patient was	656
contribute to the	656
have also been	655
cells in the	655
a study of	654
the transmission of	654
hepatitis c virus	653
igm and igg	653
in the human	652
the incidence of	652
infection with sars	648
at least one	647
be due to	645
the beginning of	644
the virus and	642
addition to the	641
was observed in	641
receptor binding domain	640
are needed to	640
detected in the	639
of critically ill	638
on the basis	636
transmission of covid	636
approved by the	634
a descriptive study	634
course of the	634
factors associated with	634
the rate of	633
changes in the	633
there was a	632
first case of	632
than that of	631
in contrast to	630
coronavirus from patients	630
to investigate the	630
characteristics of coronavirus	629
shown in table	625
the effectiveness of	625
for treatment of	624
outbreak associated with	621
responses to sars	620
by severe acute	619
depending on the	619
li et al	617
we did not	616
cd and cd	616
a pneumonia outbreak	616
the cytokine storm	616
the duration of	615
the ability of	613
none of the	613
similar to the	613
wang et al	611
spike protein of	609
of the protein	609
total number of	609
been associated with	608
risk of infection	606
number of cases	605
of infectious diseases	604
probable bat origin	603
with regard to	602
admitted to the	602
innate immune response	602
and risk factors	601
the virus to	601
new coronavirus of	599
in the future	599
in case of	599
the sars epidemic	599
pneumonia outbreak associated	598
of probable bat	598
and characterization of	597
coronavirus of probable	597
for the development	597
to the virus	596
suggest that the	595
it should be	595
compared with the	594
presence of sars	591
treatment of sars	590
systematic review of	590
a report of	590
may be a	589
each of the	588
for detection of	587
the virus is	586
is based on	586
role of the	584
seems to be	584
studies have shown	584
the potential to	583
t cell responses	581
m a n	579
risk factor for	577
is responsible for	577
in the respiratory	577
for severe acute	576
in the current	576
a case report	575
i p t	575
the n protein	575
characteristics of cases	573
of convalescent plasma	573
r i p	573
s c r	572
c r i	572
sensitivity and specificity	570
u s c	570
in a patient	570
a n u	570
n u s	570
the activity of	570
the structure of	569
it can be	569
cd t cell	569
severity of covid	568
a history of	568
obtained from the	568
the virus in	567
characterization of the	567
increase in the	567
in the covid	567
expression of the	566
center for disease	566
transmission of the	564
type i interferon	563
be used for	563
is the most	562
all of the	562
in hospitalized patients	561
the spike glycoprotein	560
higher risk of	559
in which the	557
authors declare that	557
patients with a	556
receptor for sars	556
development of a	555
can lead to	555
number of patients	555
caused by a	555
amino acid residues	554
on ace and	552
data not shown	551
of the population	551
at the end	551
in relation to	550
reported to be	549
of the world	549
infection in the	548
days after the	547
is blocked by	547
supported by the	546
with the sars	544
outbreak of severe	543
was added to	543
with or without	543
as part of	542
have been shown	542
depends on ace	542
in sars patients	542
may lead to	541
a large number	540
play a role	539
members of the	539
that the virus	538
be used as	537
cov cl pro	537
entry depends on	536
due to its	534
antibodies against sars	534
blocked by a	533
was carried out	533
a clinically proven	532
can also be	531
and is blocked	531
by a clinically	531
and tmprss and	530
of the two	530
treatment of severe	529
cell entry depends	529
nsp and nsp	529
no conflict of	528
in severe acute	528
be able to	528
characteristics of hospitalized	527
which is a	527
after symptom onset	527
and cd t	527
is consistent with	527
that there is	526
tmprss and is	525
and it is	525
h n influenza	524
cases of sars	524
proven protease inhibitor	523
version posted may	523
vitro and in	523
after the onset	523
any of the	523
clinically proven protease	522
is likely to	521
of these patients	521
the viral genome	521
are likely to	520
the mechanism of	520
binding to the	519
of ace in	518
that they have	517
on the surface	517
structure of sars	517
similar to that	517
incubation period of	517
randomized clinical trial	516
there have been	516
to identify the	516
were able to	516
could not be	514
associated with acute	514
and control of	513
wide range of	511
coronavirus pneumonia in	511
and in vivo	510
be related to	509
the innate immune	509
of infected patients	508
close contact with	507
receptor for the	505
version posted september	503
based on a	503
coronavirus infection in	503
the relationship between	503
of the host	502
were obtained from	502
preprint the copyright	502
impact of the	501
with the novel	500
respiratory tract infections	500
the potential for	500
among patients with	498
the release of	498
of the manuscript	498
severity of the	498
acute kidney injury	497
years of age	497
authors declare no	497
have not been	496
viral rna in	496
the sensitivity of	496
cases of novel	496
is shown in	495
was used as	495
was shown to	494
differences in the	494
have been identified	494
infected pneumonia in	494
that the sars	494
the viral load	493
may also be	493
the total number	492
should not be	492
there is an	491
tumor necrosis factor	490
the analysis of	489
due to a	488
in the past	487
the amount of	486
a range of	486
considered to be	486
clinical characteristics and	485
the intensive care	485
of the ace	485
a c c	484
virus in the	483
the replication of	483
in some cases	482
results of the	481
added to the	481
and middle east	480
were observed in	480
phase of the	480
of public health	479
in line with	479
during the pandemic	478
was supported by	478
novel coronavirus associated	477
domain of the	477
version posted august	477
efficacy and safety	477
of the n	476
t e d	476
the combination of	476
is essential for	476
symptoms of covid	475
the receptor binding	475
chen et al	474
a wide range	474
for the diagnosis	473
respiratory disease in	473
to prevent the	473
were associated with	473
would like to	472
characterization of a	472
e p t	471
p t e	471
is the first	470
a functional receptor	470
the first case	470
c e p	470
contributed to the	469
c c e	469
of s protein	468
ace expression in	467
in saudi arabia	467
cells of the	467
conflicts of interest	467
in the pathogenesis	466
public health emergency	465
evolution of the	465
they have no	465
and safety of	465
with a high	465
characteristics of the	463
factors for mortality	462
coronavirus in the	461
the levels of	461
e d m	461
d m a	460
s protein of	459
mechanism of action	458
different types of	458
and management of	458
is possible that	458
version posted june	458
in these patients	458
it is a	457
due to covid	456
in this review	455
the distribution of	455
was defined as	455
can be found	455
is known to	454
during the first	454
outbreak in china	454
when compared to	453
analysis of sars	453
sequence of the	453
the most important	452
new york city	452
of sars in	452
has been used	452
in a study	451
that have been	450
cov s protein	450
the interaction between	449
disease caused by	449
t cells in	449
mouse hepatitis virus	447
case fatality rate	447
the performance of	447
insights into the	446
case of sars	446
the viral rna	446
are known to	445
in this case	445
this is the	445
which can be	445
to control the	445
the occurrence of	445
in the development	444
balb c mice	444
and public health	443
the percentage of	443
suggesting that the	442
suggests that the	442
which may be	441
inpatients with covid	441
the university of	441
there were no	441
of the current	440
the virus was	440
for at least	440
the inhibition of	439
were included in	439
appear to be	438
that it is	436
a public health	436
the evolution of	436
reported in the	436
known to be	436
for min at	435
hydroxychloroquine and azithromycin	434
emerging infectious diseases	434
is necessary to	433
high risk of	433
antiviral activity of	433
data suggest that	432
suggested that the	431
for coronavirus disease	431
located in the	431
remains to be	430
of a new	430
could be used	430
impact on the	428
a group of	427
evaluation of the	426
the amino acid	426
to severe acute	426
regions of the	426
analysis was performed	426
of the clinical	425
for mortality of	425
nature of the	425
as compared with	424
no evidence of	423
in the general	423
a lack of	423
and epidemiology of	423
revealed that the	422
diagnosis of sars	421
diagnosed with covid	420
were used for	420
of the same	420
course and risk	419
for the first	419
in the literature	419
the addition of	419
the central nervous	419
mortality of adult	418
and receptor binding	418
is caused by	418
the current pandemic	418
the need to	418
adult inpatients with	418
thought to be	418
similar to those	418
in the community	417
activity of the	417
that could be	417
of adult inpatients	416
antibody responses to	416
out of the	416
and pathogenesis of	415
a set of	415
many of the	415
no competing interests	414
region of the	414
such as sars	414
case of covid	414
the discovery of	414
as a possible	414
the crystal structure	413
inhibition of sars	413
was approved by	413
may contribute to	413
were found in	412
an increased risk	412
were collected from	412
structural basis for	412
has been suggested	412
patients with mild	411
patients admitted to	411
was obtained from	411
implications for virus	411
the setting of	411
for the prevention	411
by the world	410
the cells were	410
and can be	409
declare that they	409
and evolution of	409
zhou et al	409
were treated with	408
spread of covid	408
cov spike protein	408
in vero e	407
syndrome coronavirus spike	407
the cause of	407
use of the	407
results suggest that	407
closely related to	406
of type i	406
novel coronavirus infection	406
syndrome coronavirus in	405
cytokine release syndrome	405
is an important	405
patients treated with	405
entry into the	405
igg and igm	405
of acute respiratory	405
the frequency of	405
in coronavirus disease	404
to estimate the	404
were detected in	404
as previously described	403
beginning of the	403
could be a	403
virus infection in	402
in the viral	402
of human coronavirus	402
detection of novel	402
a case series	401
is a functional	401
associated with increased	401
a global pandemic	401
in the setting	400
by the sars	400
of transmission of	400
is required for	400
pathogenesis of sars	399
zhang et al	399
chinese center for	399
has been demonstrated	399
ministry of health	399
risk of covid	398
along with the	397
this is a	397
the interaction of	397
report of cases	397
lessons from the	397
food and drug	397
chloroquine and hydroxychloroquine	396
epidemiology of novel	396
the study of	396
em structure of	395
the control of	395
the extent of	395
signs and symptoms	395
the patients with	395
were performed using	394
binding of the	394
a cluster of	394
patients who were	394
immune response in	394
have been used	393
did not have	393
origin of sars	393
of the genome	393
an analysis of	392
manifestations of covid	392
the study was	392
viral replication and	392
from the coronavirus	392
reported that the	391
testing for sars	391
to be more	391
has been found	391
in clinical trials	391
in the world	390
effect of the	390
used in this	390
of sars patients	389
which has been	389
study of the	389
outbreak of sars	389
negative for sars	389
diffuse alveolar damage	388
by the virus	388
the availability of	388
in complex with	388
use of a	387
republic of china	386
due to their	386
it may be	386
and severity of	385
the quality of	385
patients with acute	385
that of sars	385
also known as	384
higher than that	384
of ace and	384
infection by sars	383
outcomes of patients	383
herpes simplex virus	383
parts of the	382
is that the	382
of sars and	382
presence of the	382
associated with human	382
be involved in	382
version posted july	381
demonstrated that the	381
a case of	381
been found to	381
virus origins and	381
a family cluster	381
origins and receptor	380
coronavirus in patients	380
early stages of	380
there has been	379
transmission dynamics in	379
for virus origins	379
to note that	379
of the three	378
limit of detection	377
samples were collected	377
expressed in the	377
risk of sars	377
contact with the	377
for the virus	377
inhibition of the	376
for h at	376
study showed that	376
characteristics of patients	376
during the outbreak	376
in the brain	376
derived from the	375
and drug administration	375
the result of	375
for novel coronavirus	375
of patients in	375
the control group	375
prior to the	375
chronic obstructive pulmonary	374
for the covid	374
by the novel	374
in new york	373
serve as a	373
in cell culture	373
in health care	372
to the covid	371
higher levels of	371
the prevention of	371
are involved in	371
effects of the	371
obstructive pulmonary disease	371
management of covid	371
increase the risk	370
an overview of	370
member of the	370
the process of	370
in this context	369
mutations in the	369
a subset of	369
cluster of pneumonia	369
were positive for	369
of influenza a	369
syndrome in hong	368
this work was	368
the aim of	368
was found in	368
the entry of	368
yet to be	368
of the total	368
in the us	367
in the number	367
infected with the	367
cytokines and chemokines	367
spike protein and	367
we used the	367
is mediated by	367
in comparison to	367
stability of sars	366
activity against sars	366
found to have	365
binds to the	365
led to the	365
resulted in a	365
diseases such as	365
results showed that	365
is characterized by	365
to the hospital	364
a crucial role	364
replication of sars	364
novel coronavirus outbreak	364
to be associated	363
into the host	363
the rest of	363
it is likely	363
referred to as	362
the cell surface	362
stages of the	362
has been observed	362
spike glycoprotein of	362
who did not	361
is able to	361
treatment of patients	361
used to treat	361
be considered as	361
were infected with	360
for the management	360
before and after	360
detection of the	360
mediated by the	360
the design of	359
it would be	359
the causative agent	358
and development of	358
a risk factor	358
infected by sars	358
in a recent	357
in this paper	357
during the course	356
the upper respiratory	356
to detect sars	356
mesenchymal stem cells	356
are required to	356
is supported by	355
to the host	355
in severe cases	355
genomic characterisation and	355
characterisation and epidemiology	355
half of the	355
be noted that	354
of sars cov	354
of lopinavir ritonavir	354
the existence of	354
the chinese center	354
early stage of	354
is thought to	354
infection in a	354
the early stage	353
the s s	353
dynamics in wuhan	353
the main protease	353
pregnant women with	353
the mortality rate	353
the potential of	353
the public health	352
from the chinese	352
the induction of	352
of this virus	352
in patients who	352
majority of the	352
the range of	352
summarized in table	352
with the same	352
study of a	351
data from the	350
infection prevention and	350
positive and negative	350
a higher risk	349
a key role	349
s protein is	349
type i ifn	349
and mortality in	349
of infection and	349
a familial cluster	349
and that the	348
respiratory tract infection	348
proteins of sars	348
in the second	348
some of these	348
was performed on	347
the emergency department	347
the influence of	347
prevention and treatment	347
the current study	347
caused by severe	347
into host cells	347
the new coronavirus	347
in the spike	347
in the uk	347
related to covid	346
is similar to	346
shown that the	346
identified in the	346
in animal models	346
the possibility that	345
west nile virus	345
was reported in	345
of children with	345
a cohort of	345
binding domain of	344
symptoms such as	344
the association between	344
immune responses in	344
in the last	344
epidemiological characteristics of	344
be found in	344
data on the	343
of patients who	343
cases and deaths	343
for sars coronavirus	343
cause of severe	343
the application of	342
more than one	342
is involved in	342
on the use	342
in the upper	341
human respiratory disease	341
national health commission	341
infectious bronchitis virus	341
interaction with the	341
were more likely	341
have been described	341
indicated that the	341
has been described	341
during the early	340
stage of the	340
were carried out	340
the characteristics of	340
infection in children	340
patients hospitalized with	340
coronavirus nucleocapsid protein	339
of confirmed cases	339
cases from the	339
to treat covid	339
that patients with	339
to the ace	338
was able to	338
to improve the	338
familial cluster of	338
as a treatment	338
genome sequence of	338
the generation of	338
binding free energy	337
early transmission dynamics	337
of viral infection	337
in the host	337
defined as the	337
risk of transmission	336
clinical features and	336
in the management	336
sars coronavirus spike	335
a cytokine storm	335
likely to have	335
of the patient	335
convalescent plasma therapy	334
we believe that	334
in the hospital	334
cov infection in	334
may play a	334
t cells and	334
randomized controlled trial	334
are able to	333
been detected in	333
studies are needed	333
wu et al	333
the outcome of	333
of the cases	333
the probability of	333
effect on the	332
to be effective	332
intensive care units	332
reduce the risk	332
the prevention and	332
yang et al	331
with human respiratory	331
a reduction in	331
with more than	331
surface of the	331
in china and	330
that there are	330
the nucleocapsid protein	330
pneumonia associated with	330
and has been	330
control of the	330
of neutralizing antibodies	330
sensitivity of the	329
in the prefusion	329
clinical course of	329
infection control measures	329
the concentration of	329
airway epithelial cells	329
new coronavirus associated	329
lead to a	329
amino acid sequence	329
the host cells	329
is needed to	328
our understanding of	328
of the new	328
the origin of	327
in the control	327
observational cohort study	327
bind to the	327
play an important	327
well as in	327
be used in	327
has been proposed	326
of the data	326
innate and adaptive	326
at increased risk	326
were reported in	326
belongs to the	326
tested for sars	326
sars coronavirus infection	325
at the beginning	325
has led to	325
the regulation of	325
to predict the	325
was performed in	325
up to days	325
no significant difference	325
the lungs of	325
of the following	324
compared with sars	324
antigenicity of the	324
active site of	324
included in this	324
of a family	324
are the most	324
to study the	324
one or more	324
of the lung	324
but not in	324
of the main	324
to determine whether	323
followed by a	323
the degree of	323
more than of	322
this study is	322
associated with an	322
characteristics of covid	322
higher than the	321
to increase the	321
against the sars	321
the first time	321
are more likely	320
novel coronavirus indicating	320
indicate that the	320
with severe disease	320
for up to	320
immune responses to	319
should be noted	319
the function of	319
cytokine storm and	318
been reported that	318
there are several	318
with and without	318
than in the	318
in the blood	317
comparison of the	317
infection of the	317
the stability of	317
rest of the	317
did not show	317
the form of	317
leading to the	317
risk of severe	317
a h n	316
protein data bank	316
identification of the	316
other respiratory viruses	316
the virus has	316
the prefusion conformation	316
infection and the	316
of influenza virus	315
the nature of	315
should be used	315
as described above	315
elevated levels of	315
born to mothers	314
implications for the	314
lead to the	314
small number of	314
it will be	314
of the receptor	313
not yet been	313
this suggests that	313
alveolar epithelial cells	313
performed using the	313
seem to be	313
in a single	313
characteristics of and	313
confirmed cases of	312
which is the	312
a retrospective study	312
basis for the	312
important lessons from	311
early in the	311
contact with a	311
the disease and	311
it is necessary	311
of a sars	311
multisystem inflammatory syndrome	310
of ebola virus	310
the cardiovascular system	310
like to thank	310
highly expressed in	310
accordance with the	310
with the highest	310
the diagnosis and	310
information on the	309
suspected or confirmed	309
supplementary table s	309
the human population	309
liu et al	308
spike in the	308
clinical management of	308
patients who had	308
the study period	308
summary of a	308
were used as	307
the early phase	307
the safety of	307
cov m pro	307
outbreak of covid	306
in this article	306
were admitted to	306
also been reported	306
human monoclonal antibody	306
converting enzyme is	306
that may be	306
been shown that	306
related to sars	306
are summarized in	306
presence of a	306
in the elderly	305
and important lessons	305
be detected in	305
to better understand	305
in this regard	305
open reading frame	305
of t cells	305
focused on the	305
version of the	304
to be used	304
aspects of the	304
is likely that	304
safety and efficacy	304
time of the	304
that in the	304
function of the	304
infection of sars	304
remdesivir and chloroquine	304
in the population	303
of and important	303
information about the	303
of more than	303
of human coronaviruses	303
epithelial cells and	303
been used to	303
resulting in a	303
may be the	303
of personal protective	303
similar to sars	302
been observed in	302
of viral load	302
of pneumonia associated	302
by using the	302
patients with cancer	302
and viral load	302
patient with covid	302
mortality rate of	301
the united kingdom	301
the early stages	301
as in the	301
components of the	301
structural and functional	301
features of the	300
is also a	300
in this work	300
difference in the	300
t cells were	300
receptor recognition by	300
specificity of the	300
findings of covid	299
and clinical features	299
of the respiratory	299
as described in	299
that has been	299
more susceptible to	299
to our knowledge	299
in the form	299
the recognition of	299
the progression of	299
of infection in	298
of cases from	298
and specificity of	298
from the sars	298
characteristics and outcomes	298
and approved the	298
studies of sars	298
distribution of ace	297
by a novel	297
confirmed cases and	297
in vitro studies	297
the h n	297
s protein and	296
is difficult to	296
corona virus disease	296
impact of covid	296
do not have	296
high level of	296
protein is a	296
structures of the	296
could also be	296
for use in	296
to be an	295
features of covid	295
in agreement with	295
described in the	294
host immune response	294
and the other	294
and antigenicity of	294
of proinflammatory cytokines	294
has shown that	294
interaction between the	294
as a consequence	294
have been developed	294
led to a	293
together with the	293
exposure to the	293
we do not	293
syndrome in children	293
it was found	293
in the air	293
ncov spike in	292
the common cold	292
traditional chinese medicine	292
b and c	292
in the middle	292
compared to those	292
the likelihood of	292
is important for	292
in the usa	292
the recently emerged	292
entry of sars	292
and risk of	292
cases in the	292
of angiotensin converting	292
of action of	291
in light of	291
rna in the	291
by the national	291
clinical trials are	291
has been identified	291
distribution of the	290
may be due	290
enzyme is a	290
to detect the	290
to the development	290
patients with suspected	290
the centers for	290
and the number	290
important to note	290
after onset of	290
huang et al	290
with confirmed covid	289
affected by the	289
correlated with the	289
in a large	289
to explore the	289
especially in the	289
effectively inhibit the	289
mild to moderate	289
are based on	289
were tested for	288
c t s	288
protein of the	288
at higher risk	288
to analyze the	288
version posted october	288
inhibitors of sars	288
seen in the	288
viral load and	288
should be performed	288
was determined by	287
at high risk	287
of the international	287
infected with covid	287
not associated with	287
can be detected	287
and of the	287
period of time	286
in rhesus macaques	286
can be seen	286
analyses were performed	286
due to sars	286
mice infected with	286
the clinical characteristics	286
early phase of	286
was identified as	286
of the renin	286
in southern china	286
of an outbreak	286
isolation and characterization	286
results indicate that	285
aerosol and surface	285
to mothers with	285
innate immune responses	285
of viral replication	285
the purpose of	285
of a patient	285
may result in	285
at risk of	285
to inhibit the	285
bound to the	285
of the infected	284
isolated from a	284
exposure to sars	284
human coronavirus nl	284
no conflicts of	284
innate immune system	284
the viral infection	284
public health measures	284
analysis based on	284
of the literature	283
study was approved	283
human coronavirus e	283
fatality rate of	283
epithelial cells of	283
the value of	283
first step in	282
was performed by	282
to those of	282
should also be	282
expression in the	282
novel coronavirus sars	282
mediated isothermal amplification	282
context of the	282
inflammatory cytokines and	282
to compare the	281
in the course	281
in a community	281
patients with confirmed	281
the association of	281
was the most	281
of this article	281
as described previously	280
and did not	280
of a report	280
in children with	280
after the first	280
to patients with	280
is essential to	279
with the virus	279
was based on	279
the sars virus	279
the s domain	279
at least two	279
the patients were	279
treatment for covid	279
coronavirus indicating person	279
a prospective study	279
be explained by	279
to the human	279
key role in	279
the virus can	278
will need to	278
the s and	278
of at least	278
hepatitis b virus	278
have been proposed	278
outbreak of coronavirus	278
in intensive care	277
identified as a	277
the department of	277
show that the	277
this may be	277
infect dis doi	277
risk of developing	277
of cd t	277
site of the	277
is required to	276
terms of the	276
case of novel	276
the two groups	276
have been found	276
in children and	276
depends on the	276
plays an important	276
provided by the	276
may have been	276
emerged novel coronavirus	275
levels of il	275
residues in the	275
viral rna was	275
a decrease in	275
by the severe	275
further studies are	275
the source of	275
antiviral activity against	275
outcomes of critically	275
the rbd of	275
avian influenza a	275
we observed that	274
is expected to	274
nucleic acid detection	274
assessment of the	274
severe coronavirus disease	274
the dynamics of	274
is a major	274
for more than	274
recently emerged novel	274
the accuracy of	274
identified as the	274
indicating that the	274
ranging from to	274
have to be	274
studies on the	274
and chloroquine effectively	274
management of patients	274
h n virus	273
the functional receptor	273
disseminated intravascular coagulation	273
in cases of	273
for the presence	273
the type of	273
inhibit the recently	273
respect to the	273
the epidemiology of	273
mortality in patients	273
in the following	273
is due to	273
from a patient	273
chloroquine effectively inhibit	273
to examine the	272
carried out in	272
as a novel	272
an observational cohort	272
of ace protein	272
a consequence of	272
better understanding of	272
tissue distribution of	271
to the s	271
we would like	271
linked immunosorbent assay	271
can be considered	271
the lower respiratory	271
to confirm the	270
acts as a	270
the appearance of	270
institutional review board	270
to interact with	270
the size of	270
for this study	270
the viral replication	269
hospitalized with covid	269
significant difference in	269
but it is	269
hospitalized with severe	269
are responsible for	269
antibodies to sars	269
is related to	269
samples from patients	269
in upper respiratory	268
as it is	268
shows that the	268
to ensure that	268
up to of	268
onset of illness	268
in patients infected	268
case series of	268
interactions with the	268
with the use	267
have the potential	267
disease severity and	267
be responsible for	267
at the s	267
number of covid	267
course of covid	267
is used to	267
the respiratory system	267
estimated to be	267
the viral spike	266
with a higher	266
in treatment of	266
the creative commons	266
size of the	266
in humans and	266
of health care	266
were performed in	266
case of a	266
result of the	266
case of the	266
the most frequent	266
is expressed in	265
human coronavirus oc	265
influenza a h	265
considered as a	265
claims in published	265
the infection of	265
the loss of	265
a first step	265
the plasma membrane	265
susceptible to sars	265
which in turn	265
and found that	265
declare no competing	264
maps and institutional	264
the efficacy and	264
and institutional affiliations	264
leading to a	264
regard to jurisdictional	264
to jurisdictional claims	264
published maps and	264
remains neutral with	264
in published maps	264
of the rna	264
multiple sequence alignment	264
neutral with regard	264
in comparison with	264
jurisdictional claims in	264
close to the	263
springer nature remains	263
been identified as	263
compared to other	263
increased levels of	263
nature remains neutral	263
and efficacy of	262
has been associated	262
viruses such as	262
informed consent was	262
findings suggest that	262
creative commons attribution	262
pathological findings of	262
sars outbreak in	262
view of the	262
an urgent need	262
and prevention of	262
on the same	262
health commission of	262
work was supported	262
the first week	261
test for sars	261
to develop a	261
could lead to	261
inhibitors of the	261
the nlrp inflammasome	261
such as il	261
several studies have	261
may have a	261
for severe covid	261
upper and lower	261
those of the	261
immune response and	261
the involvement of	260
stability of the	260
and those with	260
the host immune	260
to be considered	260
all over the	260
is not a	260
it is worth	260
the clinical course	260
days after symptom	259
used as the	259
were added to	259
increased risk for	259
may be more	259
linked to the	259
the international committee	259
in sars coronavirus	259
van der waals	259
were incubated with	259
patients who are	259
the current covid	258
number of infected	258
the evaluation of	258
transcription polymerase chain	258
this is an	258
and the risk	258
should be taken	258
direct contact with	258
causative agent of	257
patients with chronic	257
invasive mechanical ventilation	257
cov n protein	257
a member of	257
to contain the	257
viral replication in	257
was performed with	256
and may be	256
the length of	256
of symptom onset	256
in pregnant women	256
well as a	255
was not peer	255
have been associated	255
human airway epithelial	255
previous studies have	254
written informed consent	254
was performed to	254
by the who	254
reduction in the	254
distress syndrome and	254
to minimize the	254
factors such as	254
difference between the	253
these results suggest	253
to the same	253
of exposure to	253
of the rbd	253
in china clinical	253
of all the	253
in contact with	252
the disease is	252
the hypothesis that	252
the median age	252
in view of	252
by means of	252
performance of the	252
was found that	251
the age of	251
risk factors associated	251
it could be	251
effects on the	251
median age of	251
results of an	251
to deal with	251
viral entry into	251
leads to the	250
approved the final	250
open reading frames	250
management of the	250
cells infected with	250
the authors have	250
loss of smell	250
the start of	250
the genome of	250
of m pro	250
during the study	249
study of patients	249
treatment of the	249
induced lung injury	249
acute respiratory infection	249
to provide a	249
emergency use authorization	249
of pregnant women	249
of inflammatory cytokines	249
viral shedding and	249
surface stability of	249
of hydroxychloroquine in	248
in both the	248
inflammatory bowel disease	248
the hong kong	248
international committee on	248
the implementation of	248
the general public	248
results in the	248
fact that the	248
risk of death	248
estimation of the	247
spike protein is	247
for the study	247
in the clinical	247
state of the	247
airborne transmission of	247
based on their	247
children and adolescents	247
of this disease	247
of the assay	247
the in vitro	247
human transmission of	246
all of these	246
properties of the	246
orf a and	246
upper respiratory specimens	246
from the same	246
note springer nature	246
the new york	246
are presented in	246
acute respiratory failure	246
are consistent with	246
the increase in	246
of the enzyme	246
of these drugs	246
compared to sars	246
susceptibility to sars	246
the pathophysiology of	245
and surface stability	245
in the cytoplasm	245
and there is	245
committee on taxonomy	245
the ministry of	244
on taxonomy of	244
outbreak of novel	244
in another study	244
health emergency of	244
pathogenesis of covid	244
from the first	244
critically ill covid	244
the binding affinity	244
was conducted in	244
and other respiratory	244
be considered in	244
it is unclear	243
onset of the	243
it is the	243
severe cases of	243
course and outcomes	243
tests for sars	243
cov pl pro	243
as of april	243
it is known	243
their ability to	243
replication and pathogenesis	243
in more than	243
of infected individuals	243
to test the	243
is critical for	243
antibodies against the	243
patients should be	243
exposed to the	242
the limit of	242
protein in the	242
significantly associated with	242
in figure a	242
believed to be	242
when compared with	242
global public health	242
with the exception	241
and other coronaviruses	241
at this time	241
samples from the	241
for public health	241
the acute phase	241
thermo fisher scientific	241
the efficiency of	241
rapid spread of	241
is a key	241
of healthcare workers	240
acute respiratory disease	240
of which are	240
against the virus	240
involvement of the	240
influenza virus infection	240
of chest ct	240
to the viral	240
to determine if	240
is a novel	240
and should be	239
of international concern	239
and severe acute	239
emergency of international	239
the safety and	239
inflammatory syndrome in	239
been described in	238
chronic kidney disease	238
the national health	238
followed by the	238
patients who have	238
patients during the	238
admitted to hospital	238
has to be	238
which could be	238
in all patients	238
less likely to	238
focus on the	238
a critical role	238
coronavirus spike proteins	238
we performed a	238
in vero cells	238
high prevalence of	238
respiratory viral infections	238
by the viral	238
interact with the	238
ace in the	238
acute respiratory infections	237
were identified in	237
belong to the	237
with at least	237
multiple organ failure	237
angiotensin receptor blockers	237
cases have been	237
have a higher	237
viral spike protein	237
patients with the	237
dynamics of the	237
evidence suggests that	237
as long as	237
in of the	237
viral infection and	237
of the other	237
of our study	237
has the potential	237
detection of viral	237
infection in vitro	237
group of patients	236
the d g	236
antibody responses in	236
results of a	236
of immune response	236
attributed to the	235
with disease severity	235
patients with hypertension	235
resulting in the	235
basis of the	235
emergence of sars	235
in some patients	235
molecular dynamics simulations	235
its ability to	234
based on these	234
change in the	234
lu et al	234
children with covid	234
entry into host	234
the e protein	234
guidelines for the	234
were subjected to	234
can be a	234
with the host	234
number of deaths	234
angiotensin ii receptor	234
the specificity of	234
in the field	233
is believed to	233
might be a	233
has become a	233
virological assessment of	233
of the drug	233
of cases and	233
of t cell	233
serum samples from	233
were shown to	232
in our cohort	232
we report the	232
with suspected or	232
head and neck	232
public health and	232
version posted april	232
science and technology	232
was present in	232
is defined as	232
sars in the	232
with that of	232
study was to	232
prevalence of sars	231
of hong kong	231
white blood cell	231
have demonstrated that	231
the health care	231
the inflammatory response	231
syndrome associated with	231
structural basis of	231
insight into the	231
in the lower	231
be caused by	231
assessment of hospitalized	231
to have been	230
is no evidence	230
is an urgent	230
on patients with	230
of spike protein	230
the findings of	230
to describe the	230
results from the	230
pediatric patients with	230
nucleic acid test	230
context of covid	229
ebola virus disease	229
of the innate	229
nucleic acid amplification	229
using the same	229
of a single	229
over the world	229
the administration of	229
was admitted to	229
patients who died	228
dependent on the	228
in understanding sars	228
is composed of	228
across the globe	228
national institute of	228
in vitro antiviral	228
taxonomy of viruses	228
coronavirus spike glycoprotein	228
on coronavirus disease	228
of health and	228
in most cases	228
we aimed to	228
of these viruses	228
the state of	227
serum levels of	227
adaptive immune response	227
the day of	227
on the sars	227
of the test	227
indicates that the	227
has been a	227
of the target	227
step in understanding	227
respiratory specimens of	227
severe and critical	227
of the nsp	227
for the novel	226
number of confirmed	226
a trial of	226
of infectious disease	226
expected to be	226
of clinical specimens	226
who tested positive	226
with middle east	226
clinical presentation of	226
cases of severe	226
impact of sars	226
viral nucleic acid	226
used as an	226
isolated from the	226
was identified in	225
total of patients	225
death in patients	225
determined by the	225
there may be	225
relative to the	225
a mouse model	225
and patients with	225
specimens of infected	225
report of the	225
more than million	225
of patients were	225
resulted in the	224
and activation of	224
the patients who	224
the scientific community	224
declare no conflict	224
the exception of	224
a target for	224
lower than that	224
to be infected	224
only a few	224
to the icu	224
disease in the	224
cytokine storm syndromes	224
not included in	224
a better understanding	224
transmembrane serine protease	224
systemic lupus erythematosus	224
as severe acute	223
use of corticosteroids	223
days after onset	223
according to a	223
as soon as	223
humoral immune response	223
cytokine storm in	223
and more than	223
infections in the	223
in the range	223
in conjunction with	223
within days of	223
potential role of	223
and use of	222
and disease severity	222
binding affinity of	222
to be determined	222
to bind to	222
human coronavirus infections	222
most of these	222
even in the	222
rna was detected	222
the viral envelope	222
and lower respiratory	222
low levels of	222
was confirmed by	222
note that the	222
t cell response	222
the peak of	222
coronavirus as a	222
listed in table	222
xu et al	222
lung epithelial cells	221
study clinical characteristics	221
reported to have	221
and transmission of	221
adults hospitalized with	221
understanding sars pathogenesis	221
for this reason	221
adaptive immune responses	221
the sequence of	221
the first days	221
in association with	221
duration of the	221
in table s	221
to the lack	221
clinical and epidemiological	221
of ace expression	220
of the potential	220
tested negative for	220
version posted november	220
disease severity in	220
a randomized clinical	220
of patients had	220
affected by covid	219
the synthesis of	219
for viral replication	219
that there was	219
positive for covid	219
was reported to	219
in south korea	219
is known about	219
in of patients	219
be a potential	219
urgent need for	219
and igg antibodies	219
two of the	219
is not yet	218
we show that	218
we compared the	218
glycoprotein of sars	218
and acute respiratory	218
macrophage activation syndrome	218
more severe disease	218
d g mutation	218
and incubated for	218
from severe acute	218
rapid detection of	217
n and n	217
the reduction of	217
recent studies have	217
the first two	217
peripheral blood mononuclear	217
proteins of the	217
to viral infection	217
cohort of patients	217
basic reproduction number	217
and h n	217
value of the	217
a possible cause	217
and characteristics of	217
to the high	216
load in upper	216
it is difficult	216
in adults hospitalized	216
the significance of	216
of the cell	216
the difference in	216
of spike glycoprotein	216
all authors have	216
patients had a	216
significant differences in	216
possible cause of	216
isolation of a	216
it was also	216
quality of life	216
this study were	215
protein and the	215
appeared to be	215
of the samples	215
available in the	215
decrease in the	215
and death in	215
contrast to the	215
be attributed to	215
of the vaccine	215
respiratory syndrome virus	215
the ratio of	215
the site of	215
and analysis of	215
with a history	215
its spike protein	215
to limit the	214
have been observed	214
group of the	214
results in a	214
of the lungs	214
knowledge of the	214
of antibodies against	214
the timing of	214
also found that	214
nucleocapsid protein of	214
with convalescent plasma	214
may be related	214
potential of sars	214
virus entry and	213
are similar to	213
associated with higher	213
the differences in	213
as high as	213
the vast majority	213
in healthcare settings	213
of the four	213
are in the	213
i and ii	213
type i and	213
the gold standard	213
study on the	213
outbreak of the	213
pneumonia of unknown	213
the most promising	213
consider cytokine storm	212
department of health	212
associated with poor	212
efficacy of the	212
blood mononuclear cells	212
of the major	212
time of writing	212
hong kong and	212
because of its	212
proportion of patients	212
feline infectious peritonitis	212
of clinical trials	212
cell entry and	212
standard of care	212
lung injury and	212
across the world	212
analysis showed that	212
with an increased	212
the magnitude of	211
and incubated at	211
differences between the	211
be the most	211
with lopinavir ritonavir	211
evolution of sars	211
which have been	211
number of people	211
immunodeficiency virus type	211
this type of	211
this study are	211
a function of	211
storm syndromes and	211
origin of the	211
transmission of severe	211
the index case	211
neutralizing antibodies against	210
estimates of the	210
neonates born to	210
reactive oxygen species	210
infection of human	210
transferred to the	210
are listed in	210
neutrophil extracellular traps	210
time reverse transcription	210
virus and the	210
preprint in the	209
majority of patients	209
were used in	209
the lungs and	209
in the two	209
syndromes and immunosuppression	209
consent was obtained	209
the first cases	209
cleavage of the	209
immune system and	209
the n gene	209
the infectivity of	209
are expected to	208
and adaptive immune	208
we used a	208
to the intensive	208
sequences of the	208
explained by the	208
of respiratory viruses	208
have been published	208
the response to	208
patients presenting with	208
prospective cohort study	208
has not yet	208
of which were	208
is present in	208
was no significant	208
azithromycin as a	208
to play a	208
better understand the	208
structural studies of	208
response in patients	207
species severe acute	207
likely due to	207
smell and taste	207
in cancer patients	207
of the brain	207
the antiviral activity	207
in china a	207
in peripheral blood	207
aim of this	207
in different types	207
damage to the	207
is known that	207
corresponding to the	207
in a small	206
rate of sars	206
in the new	206
critical role in	206
are present in	206
form of the	206
or in combination	206
crucial role in	206
and azithromycin as	206
can result in	206
a major outbreak	206
and cardiovascular disease	206
to public health	206
of the present	206
hydrogen bonds with	206
of h n	206
a treatment of	206
a role for	205
been used in	205
for each of	205
is not clear	205
specific cd t	205
there are many	205
on the contrary	205
women with covid	205
the clinical and	205
whether or not	205