bigram

This is a table of type bigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

bigram	frequency
necrosis factor	975
immune response	919
mg kg	812
immune system	800
dendritic cells	779
cell line	779
inflammatory cytokines	772
endothelial cells	770
gene expression	757
peripheral blood	738
cell lines	718
nk cells	683
tumor necrosis	682
inflammatory response	668
cell death	629
immune responses	617
flow cytometry	602
ng ml	562
present study	530
nitric oxide	528
control group	525
important role	515
cell proliferation	506
significantly higher	503
growth factor	492
amino acid	487
type i	484
septic shock	475
lymph nodes	475
pg ml	468
cytokine production	450
mononuclear cells	441
results suggest	428
innate immune	424
mrna expression	413
mbl levels	406
healthy controls	386
bone marrow	377
oxidative stress	370
cancer cell	363
adhesion molecules	354
blood samples	349
significantly increased	347
breast cancer	346
lung injury	346
epithelial cells	346
blood mononuclear	330
results indicate	328
intensive care	319
tumour necrosis	313
rheumatoid arthritis	310
cancer cells	303
acute respiratory	296
endothelial cell	296
complement activation	294
immune cells	293
cell surface	286
multiple sclerosis	286
transcription factor	284
class ii	283
cell activation	275
cell types	275
iga protease	273
binding lectin	272
cell responses	270
blood flow	268
inflammatory cytokine	267
type ii	256
cd cd	254
clinical signs	253
blood pressure	251
ex vivo	250
proinflammatory cytokines	248
class i	248
statistically significant	248
protein kinase	247
significant increase	247
cell cycle	246
inflammatory mediators	245
smooth muscle	245
high levels	242
iga antibody	240
monoclonal antibody	239
time pcr	237
nervous system	236
whole blood	236
data suggest	233
inflammatory responses	232
western blot	231
cd expression	228
organ failure	227
increased levels	226
signal transduction	226
ms patients	226
influenza virus	225
mrna levels	223
protein expression	220
serum levels	220
spinal cord	218
natural killer	217
activated macrophages	217
dependent manner	217
mouse model	215
virus infection	213
significantly lower	212
vascular endothelial	211
cellular immune	209
like domain	209
chronic inflammatory	208
significantly reduced	205
inflammatory diseases	204
critically ill	202
acute lung	201
significant difference	200
blood donors	199
viral infection	198
significant differences	197
herpes simplex	197
reactive oxygen	197
cytokine storm	196
patients receiving	193
clinical trials	192
type diabetes	192
results showed	191
respiratory syndrome	190
mechanical ventilation	190
stem cells	188
cells may	186
specific cd	186
signaling pathway	185
time points	185
healthy individuals	184
simplex virus	184
lactic acid	182
signaling pathways	182
critical role	182
may play	181
acute phase	181
innate immunity	180
binding site	180
may also	180
multiple organ	178
two groups	177
oral mucosa	177
performed using	177
tumour cells	177
proliferating cells	176
severe acute	176
alternatively activated	175
adaptive immunity	175
colorectal cancer	174
monoclonal antibodies	174
cell response	172
pivotal role	171
transcription factors	171
central nervous	171
human collectins	171
pattern recognition	171
autoimmune diseases	170
mast cells	170
respiratory distress	170
acid bacteria	169
genes involved	169
tumor cells	169
pregnant women	168
wild type	168
mg ml	168
lectin pathway	167
adhesion molecule	165
like receptor	163
plasma levels	163
may contribute	162
animal models	162
side effects	161
blood cells	160
oxygen species	160
mhc i	159
mhc class	159
recent studies	158
distress syndrome	158
deficient mice	158
cell adhesion	156
macrophage activation	156
small intestine	155
inflammatory bowel	154
plasma membrane	154
doc id	153
cord uid	153
expression levels	152
inflammatory effects	151
peritoneal macrophages	150
molecular mechanisms	150
taken together	150
western blotting	150
determine whether	149
protease activity	149
fatty acids	149
stem cell	148
adipose tissue	148
ill patients	148
commercially available	147
may therefore	147
activated protein	147
binding assays	146
surface expression	145
amino acids	145
body weight	145
healthy volunteers	145
mice immunized	144
ear skin	143
risk factors	143
protective effect	143
i molecules	142
results demonstrate	142
cancer patients	142
previous studies	142
higher levels	142
clinical trial	141
gut flora	141
patients compared	141
increased expression	141
escherichia coli	141
increased risk	141
significantly decreased	141
antiviral activity	140
th cells	140
growth factors	140
findings suggest	140
inflammatory cells	140
molecular weight	139
receptor antagonist	139
dc maturation	139
apoptotic cells	139
statistical analysis	138
control donors	138
bowel disease	138
autologous bacteria	138
small intestinal	138
humoural responses	137
proteome analysis	137
tnf production	137
viral infections	137
epithelial cell	137
peptide antigens	137
healthy donors	136
corresponding hc	136
high mbl	136
alveolar macrophages	136
lactobacillus spp	136
recombinant human	135
receptor expression	135
major role	135
host defense	134
gestational age	134
cd cells	134
ifn species	134
care unit	134
oxide synthase	134
systemic lupus	134
insulin resistance	133
intracellular ifn	133
cardiac output	133
cell subsets	133
lymph node	133
human blood	133
proinflammatory cytokine	132
like receptors	132
sentinel lymph	132
lactobacillus acidophilus	132
related lipoproteins	132
white blood	131
endothelial growth	131
transforming growth	131
preliminary results	131
lupus erythematosus	130
septic patients	130
target cells	129
infected cells	129
reperfusion injury	129
university hospital	128
severe covid	128
binding protein	128
negative bacteria	127
findings indicate	127
clinical use	127
surface markers	126
infected mice	126
blot analysis	125
mast cell	125
heat shock	125
binding proteins	125
specific antibodies	125
airway inflammation	124
patienten mit	124
analysed using	123
viral replication	123
cell type	123
vitro stimulation	123
may provide	122
risk factor	121
sequence homology	121
ko mice	121
human peripheral	121
bronchial asthma	120
nuclear factor	120
complement system	120
th th	120
myocardial infarction	120
systemic inflammatory	120
factor alpha	120
disease activity	120
fish oil	120
beneficial effects	119
mean age	119
disease severity	119
dna damage	119
control animals	118
mass spectrometry	118
type ifn	118
heart failure	118
adaptive immune	117
dna vaccine	117
healthy blood	117
cytokine profile	117
cytokine levels	117
human recombinant	117
severe sepsis	116
key role	116
regression analysis	116
cell function	116
currently investigating	116
also found	115
organ dysfunction	115
nk cell	115
cell culture	115
cytokines il	115
central role	114
serine proteases	114
cell cytotoxicity	114
results will	114
two different	114
normal human	113
single nucleotide	113
may help	113
protein levels	113
sendai virus	112
tumour cell	112
heart rate	112
lower levels	111
weight loss	111
results show	111
allergic rhinitis	111
presenting cells	110
cell count	110
cell growth	110
cell cultures	109
first time	108
th phenotype	108
cell viability	108
cell receptor	108
inhibitory effect	108
cell migration	108
serine protease	107
positive cells	107
antigen presentation	107
human monocytes	107
response towards	107
converting enzyme	106
data indicate	106
dna vaccination	106
pss patients	106
normal mucosa	105
complement activity	105
extracellular matrix	105
iga antibodies	105
muscle cells	105
lipid peroxidation	105
staphylococcus aureus	104
fatty acid	104
wound healing	104
inflammatory disease	104
special emphasis	104
pulmonary artery	104
stranded rna	104
dairy cows	103
target bacteria	103
clonally expanded	103
oral carcinoma	103
high concentrations	103
mg dl	103
bioinformatics tools	103
macrophage galactose	102
induced apoptosis	102
weak il	102
mbl genotypes	102
cytokine responses	102
mbl double	102
ectopic gc	102
virus type	102
serum mbl	102
protein level	102
reactive protein	102
nkt cells	101
acid residues	101
protein synthesis	101
plasmodium falciparum	101
renal failure	101
binding regions	101
cytokine tumour	101
differentially expressed	101
mammalian cells	100
global proteome	100
arachidonic acid	100
protein microarrays	100
bacteria lactobacillus	99
antibody microarrays	99
immune complexes	99
venous blood	99
apoptotic cell	99
cell reactivity	99
database system	99
hla supertypes	99
ml kg	99
diabetes mellitus	99
different time	99
transduced eph	99
bacterial antigen	99
mbl masp	99
apache ii	98
previously shown	98
fusion proteins	98
skeletal muscle	97
clinical studies	97
superoxide dismutase	97
may cause	97
tnf receptor	96
colon cancer	96
fusion protein	96
using flow	96
previously reported	96
acute pancreatitis	95
group i	95
significantly elevated	95
gastrointestinal tract	95
fold increase	95
transgenic mice	95
tissue damage	95
control subjects	94
gel electrophoresis	94
low levels	94
nucleotide polymorphisms	94
large intestine	94
cytokine response	94
long term	93
cell differentiation	93
normal subjects	93
significantly associated	92
cardiovascular disease	92
significantly different	92
killer cell	92
body mass	92
recently identified	92
may result	92
may lead	92
possible role	92
years old	92
cell survival	92
studies will	91
negative feedback	91
human lung	91
cells showed	90
mechanisms underlying	90
two patients	90
three different	90
infected patients	90
stimulating factor	90
trauma patients	90
respiratory tract	90
control groups	89
chronic inflammation	89
fold higher	89
analysis revealed	89
crucial role	89
may occur	89
recognition receptors	89
protein content	88
arterial blood	88
ca i	88
arterial pressure	88
cytokine release	88
measured using	88
significant decrease	88
factor receptor	88
immunized mice	88
i ifn	88
tissue factor	87
high amounts	87
mortality rate	87
ra patients	87
igg antibodies	87
assay using	86
cancer treatment	86
er stress	86
animal model	86
activating factor	86
large number	86
allergic airway	86
patients presented	85
carcinoma cell	85
infl ammatory	85
significant reduction	85
real time	85
autoimmune disease	85
increased significantly	85
falciparum malaria	84
respiratory failure	84
less pronounced	84
icu patients	84
lung tissue	84
wt mice	84
survival rate	84
systemic inflammation	83
human il	83
bladder cancer	83
induced release	83
widely used	83
cd ra	83
kg day	83
major source	82
cord injury	82
human monoclonal	82
one study	82
closely related	82
endoplasmic reticulum	82
antibodies specific	82
response syndrome	82
one may	82
cells express	81
cell epitopes	81
free radicals	81
brain injury	81
treatment group	81
bl mice	81
serum samples	81
first trimester	81
amniotic fluid	81
complement components	81
tissue injury	81
increased production	80
weeks post	80
medical center	80
vascular resistance	80
serum albumin	80
effector cells	79
will allow	79
lung inflammation	79
tumor cell	79
ang ii	79
crystal structure	79
cells within	79
plasma cells	79
type cytokines	79
dose dependent	79
ml min	79
psoriatic skin	78
cytokine secretion	78
investigated whether	78
expression pattern	78
naturally occurring	78
regional lymph	77
vitro studies	77
also known	77
promoter region	77
previously described	77
induced il	77
subsequent development	77
vascular endothelium	77
syndrome coronavirus	77
molecular markers	77
cysteine protease	77
coli lps	77
murine model	77
cell apoptosis	77
lung cancer	77
high risk	77
virus replication	76
related molecules	76
diabetic patients	76
poor prognosis	76
single amino	76
i ifns	76
patients showed	76
terminal part	76
peritoneal fluid	76
liver injury	76
experimental autoimmune	76
total rna	76
large amounts	76
acute myocardial	75
investigate whether	75
large colon	75
elevated levels	75
cell layer	75
fas ligand	75
mice compared	75
fetal growth	75
inflammatory process	75
current study	74
derived peptides	74
cd bright	74
feedback regulation	74
mesenchymal stem	74
infectious diseases	74
expression profiles	74
found among	74
induced arthritis	74
vascular permeability	74
myeloid cells	74
produce il	74
logistic regression	74
costimulatory molecule	74
marginal zone	74
mouse models	74
major histocompatibility	74
linked immunosorbent	74
coronavirus disease	73
plasma samples	73
nonstructural protein	73
biological activity	73
map kinase	73
analyzed using	73
mediated immunity	73
maturation markers	73
cells decreased	73
high dose	73
human gut	73
monitor patients	73
high affinity	73
tyrosine kinase	73
future studies	73
peptide ligands	72
dust mite	72
therapeutic approach	72
also may	72
patients treated	72
knockout mice	72
vascular complications	72
wide range	72
hydrogen peroxide	72
activation state	72
th response	72
flow cytometric	72
acid substitution	72
lcm virus	71
predisposing factor	71
autoimmune encephalomyelitis	71
ko animals	71
pylori infection	71
dietary vitamin	71
increasingly used	71
specific cytotoxic	71
several studies	71
showed increased	71
postoperative infections	71
protective effects	71
large panel	71
respiratory syncytial	71
ischemia reperfusion	71
blood cell	71
rat model	71
cardiogenic shock	71
first step	70
release assay	70
activate nk	70
immunomodulatory therapies	70
critical care	70
lactobacillus rhamnosus	70
model system	70
gastric juice	70
lg ml	70
bacterial strains	70
patients without	70
splenic cd	70
induced rantes	70
peptides spanning	70
carcinoma cells	70
culture supernatants	70
positive correlation	70
commensal bacteria	70
rantes expression	70
immune cell	70
currently trying	70
dm patients	70
cytokine environment	70
antibody fragments	70
ii cytokine	70
adaptor molecules	70
within hours	69
membrane depolarization	69
virus nonstructural	69
children living	69
eae induction	69
syncytial virus	69
contact sensitivity	69
protein microarray	69
cell membrane	69
dna construct	69
focus score	69
ctl activity	69
mt mt	69
quantitative real	69
soluble vascular	69
solid supports	69
inducible nitric	69
tlr adaptor	69
macrovascular complications	69
recall stimulation	69
type mice	69
colon mucosa	69
mt cells	69
peptide mapping	69
responsiveness ex	68
pathological conditions	68
type lectins	68
allergic asthma	68
may influence	68
specific immune	68
reactive lymphocytes	68
ingested probiotics	68
associated serine	68
genes encoding	68
pneumoniae serotypes	68
oligoadenylate synthetases	68
noise threshold	68
bifidobacterium spp	68
novel markers	68
hydrophobic interaction	68
low tnf	68
immature dcs	68
pressurized chamber	68
aureus serotypes	68
human mnsod	68
programmed cell	68
double ko	68
fluticasone propionate	68
tcr vb	68
pylori igg	68
rhamnosus gg	68
laboratory information	68
mbl ko	68
mt phenotype	68
cytotoxicity increased	68
normoalbuminuric group	68
derived macrophages	68
histocompatibility complex	68
bronchoalveolar lavage	68
including ingested	68
will address	68
potentially immunogenic	68
igg caga	68
mbl gene	68
persons working	68
macrophage inflammatory	68
sows fed	68
protected rats	68
five putative	68
hyperbaric exposure	68
patients undergoing	68
protease inhibitor	68
chain reaction	68
ics alone	68
mt ratio	68
malarial antigen	68
immune status	68
seroimmunological phenotype	68
normal colon	68
final visit	68
ifn biologicals	67
titrations making	67
i interferon	67
interaction chromatography	67
serum resistance	67
birth weight	67
versus mg	67
better reporter	67
times higher	67
mammary gland	67
standard operating	67
adverse effects	67
laborious titrations	67
assays require	67
gene products	67
cell population	67
intercellular contact	67
require laborious	67
protease domains	67
induces apoptosis	67
carried using	67
ae sem	67
micro flora	67
inducible costimulator	67
scale clinical	67
zinc deficiency	67
predicted binding	67
activate complement	67
recognition molecules	67
unique possibility	67
bioavailability varies	67
antiviral neutralization	67
bacterial stimulation	67
mbp antibodies	67
one patient	67
determined using	67
induced complement	67
derived antigens	67
hyperimmunized mice	66
svegfr concentrations	66
operating procedures	66
recognition molecule	66
qbc experiment	66
mbl pathway	66
antitumour response	66
mblassociated serine	66
pseudomonas aeruginosa	66
ficolin ml	66
different lab	66
variant tumour	66
mg bd	66
ethyl pyruvate	66
hepatocellular carcinoma	66
macrophages elicited	66
zone macrophages	66
microbial surfaces	66
polymerase chain	66
homing cutaneous	66
also observed	66
may become	66
peptide epitopes	66
sentinel nodes	66
database solution	66
enriched ann	66
plasma svegf	66
hla supertype	66
allergen carriers	66
lymphocyteassociated antigen	66
host immune	66
sarcoid origin	66
generation anns	66
microarrays will	66
unstimulated cd	66
novel allergen	66
rich data	66
abdominal pain	66
mediated opsonophagocytosis	66
pulmonary tb	66
qbc peptides	66
masp activity	66
mammalian cytokine	66
laboratory notebooks	66
highthroughput global	66
invertebrate pattern	66
transduced cell	66
nonsentinel lymph	66
affect nk	66
boost vaccinations	66
culture medium	66
tnf blockade	66
svegfr release	66
containing ic	66
preoperative mbl	66
tumour extract	66
blood leucocytes	66
specific nucleotidyl	66
hemorrhagic shock	66
obtain tumour	66
clinical data	66
cutaneous lymphocyteassociated	66
mbl concentration	66
active site	65
iav infection	65
clinical course	65
data show	65
immunodeficiency virus	65
free radical	65
inhibitory effects	65
study included	65
may indicate	65
also induces	65
ob gyn	64
pulmonary hypertension	64
vaccinia virus	64
inflammatory activity	64
using elisa	64
alveolar epithelial	64
activity may	64
previously demonstrated	64
healthy control	64
commonly used	64
increased susceptibility	64
kinase activity	64
healthy subjects	63
sertoli cells	63
oleic acid	63
antibody responses	63
juvenile idiopathic	63
five patients	63
cells play	63
time course	63
differential expression	63
every hours	63
antibody response	63
three groups	63
enzyme activity	63
cardiac surgery	63
selectin expression	63
coronary artery	63
study group	63
expression level	63
red blood	63
idiopathic arthritis	62
tumor growth	62
may represent	62
bei patienten	62
also play	62
largely unknown	62
cord blood	62
protective role	62
study design	62
regulatory role	62
potential therapeutic	62
mediated immune	62
ovarian cancer	62
dna binding	62
cells expressing	62
four different	61
costimulatory molecules	61
cellular response	61
cytokine expression	61
novel coronavirus	61
estrogen receptor	61
first line	61
reporter gene	61
inflammatory reaction	61
group ii	61
induced inflammatory	61
levels may	61
compared using	61
hours following	61
blood monocytes	60
high degree	60
studies revealed	60
inflammatory gene	60
angiotensin ii	60
cell lymphoma	60
may serve	60
protein kinases	60
may affect	60
target genes	60
kg body	60
th responses	60
environmental factors	60
binding sites	60
higher risk	60
two types	60
human endothelial	60
well known	60
fully understood	60
microarray analysis	60
treated mice	60
prospective study	59
higher concentration	59
showed significant	59
lipid rafts	59
much higher	59
patient groups	59
human disease	59
cell functions	59
kg min	59
family history	59
two major	59
statistical significance	59
th cytokines	59
matched controls	59
severe cases	59
intercellular adhesion	59
recent years	59
full length	59
data provide	59
data demonstrate	59
cell carcinoma	59
studies suggest	58
death domain	58
also expressed	58
plasma concentrations	58
studies showed	58
shock protein	58
systematic review	58
prostate cancer	58
inflammatory processes	58
one hand	58
using different	58
evidence indicates	58
proteolytic cleavage	58
direct effect	58
patients received	58
significant correlation	58
renal disease	58
lactate dehydrogenase	58
patients admitted	57
primary human	57
host response	57
also evaluated	57
increasing evidence	57
findings may	57
odds ratio	57
genetic background	57
leydig cells	57
inflammatory effect	57
progenitor cells	57
ii mhc	57
basic protein	57
analysis showed	57
mm hg	57
bei der	57
physiological conditions	56
buffered saline	56
least one	56
direct effects	56
total protein	56
gene polymorphisms	56
mean arterial	56
renal dysfunction	56
immune function	56
inkt cells	56
promoter activity	56
vascular smooth	56
potential role	56
acute renal	56
treated cells	56
oxide production	56
cell mediated	55
oxygen saturation	55
mice lacking	55
lung function	55
tissue sections	55
regression model	55
mice infected	55
myelin basic	55
low level	55
poorly understood	55
mycobacterium tuberculosis	55
infectious complications	55
controlled trial	55
recently demonstrated	55
electron microscopy	55
oxygen delivery	55
using standard	55
monocytes macrophages	55
inflammatory markers	55
antigen presenting	55
oral cavity	54
university medical	54
retrospective study	54
ii score	54
growth restriction	54
may explain	54
highly significant	54
cell populations	54
body temperature	54
induced acute	54
cell development	54
family members	54
mediated inflammatory	54
also used	54
united kingdom	54
synthetic peptides	54
skin lesions	54
dendritic cell	54
human immunodeficiency	54
cell degranulation	54
clinical response	54
one hour	54
hormone receptors	54
ms ms	54
dawley rats	54
inflammatory cell	54
experiments showed	54
antigen expression	53
hek cells	53
cellular stress	53
brain barrier	53
provide new	53
mononuclear phagocytes	53
bacterial infection	53
directed mutagenesis	53
signalling pathways	53
th immune	53
umbilical cord	53
activation syndrome	53
results may	53
gastric mucosa	53
group compared	53
control mice	53
related proteins	53
trophoblast cells	53
biologically active	53
derived dendritic	53
hsv infection	53
preterm delivery	53
will also	53
und der	53
bacterial infections	52
stimulatory effect	52
higher incidence	52
endothelial dysfunction	52
signal peptide	52
positive bacteria	52
lps stimulation	52
nude mice	52
recently reported	52
preterm birth	52
surgical procedures	52
mechanically ventilated	52
nutritional status	52
ion channels	52
xanthine oxidase	52
ii expression	52
clinical features	52
blood sample	52
helicobacter pylori	52
umbilical vein	52
ulcerative colitis	52
severe disease	52
collagen type	52
connective tissue	52
phase proteins	52
patients suffering	51
new therapeutic	51
intravascular coagulation	51
independent manner	51
molecules involved	51
seven days	51
weight gain	51
may improve	51
tlr expression	51
blood gases	51
confocal microscopy	51
observation period	51
disease progression	51
reduced il	51
blood loss	51
higher level	51
sars patients	51
metabolic acidosis	51
transduction pathways	51
still unclear	51
blood vessels	51
inflammatory properties	51
lung disease	50
signalling pathway	50
useful tool	50
low dose	50
fat diet	50
vg vd	50
toxic effects	50
time point	50
positively charged	50
coupled receptors	50
informed consent	50
low concentrations	50
type diabetic	50
lung carcinoma	50
cells might	50
therapeutic target	50
time rt	50
first hours	50
necrotizing enterocolitis	50
mechanisms involved	50
wildtype mice	50
phase i	50
elisa method	50
laser scanning	50
alternative pathway	50
receptor agonist	50
menstrual cycle	50
healthy human	50
stromal cells	49
considered statistically	49
laboratory data	49
early stage	49
salivary glands	49
immune reaction	49
last decade	49
bacterial translocation	49
infl ammation	49
nlrp inflammasome	49
wistar rats	49
allergic reactions	49
cell sorting	49
human umbilical	49
united states	49
intestinal inflammation	49
different groups	49
infection may	49
genomic dna	49
important implications	49
cells increased	49
tissue samples	48
mhc ii	48
germinal centers	48
acute infection	48
proteins may	48
vast majority	48
independent pathways	48
sepsis syndrome	48
differences among	48
tumor suppressor	48
tnf secretion	48
marker cd	48
mice showed	48
every weeks	48
structurally related	48
cardiac index	48
patients infected	48
important roles	48
genetic predisposition	48
blood sampling	48
gas exchange	48
platelet aggregation	48
adult horses	48
cytokine il	48
heart disease	48
surfactant protein	48
inflammatory stimuli	48
containing proteins	48
inhibits apoptosis	48
stage renal	48
surface antigen	48
secondary antibody	48
present results	48
activation via	48
specific primers	47
different species	47
molecular biology	47
also examined	47
disseminated intravascular	47
proliferative response	47
high level	47
death receptor	47
complex i	47
severe malaria	47
circulating levels	47
inflammatory skin	47
treated animals	47
preterm labor	47
pulmonary edema	47
pulmonary vascular	47
circulating neutrophils	47
results also	47
lactate levels	47
times lower	47
initial phase	47
response rates	47
even though	47
demyelinating disease	47
different cell	47
mit einer	47
induced lung	47
different molecular	47
viral load	47
ripk kinase	47
central venous	47
human colon	47
peritoneal cavity	47
study suggest	47
dramatically increased	47
parenteral nutrition	47
acute viral	47
left ventricular	47
gastrointestinal mucosa	46
human cd	46
negative regulators	46
pregnant rats	46
general hospital	46
data presented	46
squamous cell	46
recent study	46
cpg dna	46
longitudinal study	46
case report	46
placebo group	46
almost exclusively	46
host cells	46
increased il	46
highly pathogenic	46
respiratory disease	46
interferon gamma	46
associated antigen	46
molecular mass	46
may account	46
lung epithelial	46
human myometrium	46
colorectal carcinoma	46
inhibitory activity	46
renal function	46
interferon production	46
pulmonary disease	46
derived dcs	46
glucose tolerance	46
clinical outcome	46
increased cell	46
cohort study	46
may allow	46
chemokine expression	46
host disease	46
protein production	46
serum total	45
patients died	45
randomly selected	45
coagulation factor	45
nuclear receptor	45
glucose levels	45
may modulate	45
significantly inhibited	45
thymidine incorporation	45
liver cirrhosis	45
ligand interactions	45
study involved	45
two doses	45
critical illness	45
regulated genes	45
normal individuals	45
five different	45
inflammatory mechanisms	45
also capable	45
low expression	45
virus infections	45
control cells	45
lymphocytic choriomeningitis	45
significant changes	45
days pi	45
matched healthy	45
human beings	45
cells treated	45
scanning microscopy	45
cellular mechanisms	45
also showed	45
mg daily	45
molecular mimicry	45
therapeutic strategies	45
tidal volume	45
lower doses	45
cytotoxic cd	45
membrane potential	45
using human	45
six hours	45
different concentrations	44
study period	44
days post	44
tlr ligands	44
previous study	44
asthmatic patients	44
tnf receptors	44
stress response	44
induced tnf	44
subsequent activation	44
significant association	44
nadph oxidase	44
specific cellular	44
mammalian cell	44
studies indicated	44
gland tissue	44
high fat	44
production induced	44
whether il	44
coding regions	44
skin disease	44
culture media	44
cancer immunotherapy	44
also significantly	44
elisa technique	44
valuable tool	44
blood levels	44
salivary gland	44
immune dysregulation	44
enzyme activities	44
receptor signaling	44
direct contact	44
shock proteins	44
prospective studies	44
induced ifn	44
using gene	44
sex hormone	44
und die	44
blood glucose	44
mitochondrial membrane	44
lower risk	44
bovine serum	44
routine clinical	44
weeks gestation	44
receptor signalling	43
well tolerated	43
early stages	43
animal studies	43
gram negative	43
gene family	43
induced macrophage	43
human epidermal	43
signal intensity	43
important regulator	43
inflammatory disorders	43
human dendritic	43
lower dose	43
leading causes	43
leptin receptor	43
surface plasmon	43
mice treated	43
intestinal flora	43
decreased significantly	43
soluble tnf	43
studies suggested	43
type immune	43
remains unclear	43
zinc supplementation	43
bacterial antigens	43
plasmon resonance	43
diabetic nephropathy	43
significantly better	43
occurs via	43
immunological responses	43
allow us	43
peripheral cd	43
median age	43
translational modification	43
increased release	43
single dose	43
gene transcription	43
immunol doi	43
acquired immunity	43
one patients	43
malignant transformation	43
molecular medicine	43
including il	43
assessed using	43
active molecules	43
cd may	43
hla class	43
survival time	43
individual patients	43
proteins involved	42
pcr technique	42
elisa kits	42
respiratory viruses	42
induced cell	42
levels increased	42
binding studies	42
da rats	42
large intestinal	42
different proteins	42
mean tnf	42
strongly inhibited	42
urinary bladder	42
also indicated	42
killer cells	42
ige levels	42
treated group	42
colony stimulating	42
liquid chromatography	42
positive control	42
rheumatic diseases	42
significant role	42
specific ctl	42
unstimulated cells	42
room temperature	42
acid sequence	42
therapeutic potential	42
induced inflammation	42
studied whether	42
nuclear translocation	42
associated immune	42
various cancer	42
induce il	42
mannose receptor	42
using non	42
adenosine receptors	42
leukocyte adhesion	42
fetal membranes	42
confocal laser	42
rna isolated	42
fl uid	42
median values	42
potential risk	42
cultured human	42
inflammatory conditions	42
directly induce	42
phase ii	42
even higher	42
studies involving	42
histamine release	42
plasminogen activator	41
biological properties	41
play important	41
infected fetuses	41
induce expression	41
barrier function	41
female patients	41
blood cd	41
express il	41
induced significant	41
beneficial effect	41
specific ifn	41
regulatory cytokines	41
particularly important	41
health effects	41
complement factor	41
dna methylation	41
blood stem	41
androgen receptor	41
medical school	41
cov infection	41
factors like	41
specific immunity	41
pharmakologie und	41
important part	41
promote cell	41
significant expression	41
infl uence	41
important regulators	41
injected i	41
health care	41
cardiovascular diseases	41
cell infiltration	41
two distinct	41
binding region	41
molecular mechanism	41
medical microbiology	41
borrelia burgdorferi	41
bacterial products	41
reproductive tract	41
immune modulation	41
acid sphingomyelinase	41
different diseases	41
eicosanoid synthesis	41
also exist	41
standard deviation	41
various times	41
bead array	41
ischemic stroke	41
wide spectrum	41
intraperitoneally injected	41
surface receptors	41
plasma protein	41
exclusion chromatography	41
chronic obstructive	41
kb activation	41
mice bearing	41
cutaneous lymphocyte	41
apoptotic signal	41
autoantibody production	41
cellular interactions	41
essential role	41
light microscope	41
acts via	41
studies using	41
specific ige	41
trypanosoma cruzi	41
mediated disease	41
antigenpresenting cells	41
producing cells	41
mass index	41
like structure	41
ii mrna	41
monocytic cell	41
much greater	41
psoriasis patients	40
ii cells	40
multivariate regression	40
similar effect	40
soluble antigens	40
severe influenza	40
increased cd	40
may potentially	40
host cell	40
epitope specificity	40
suppressor cells	40
binding motif	40
induced cd	40
million people	40
vaccine design	40
recombinant fusion	40
multiple trauma	40
address whether	40
systemic vascular	40
mean ae	40
adverse events	40
high mortality	40
cytotoxic activity	40
germ cells	40
sequence similarity	40
increasing age	40
growth arrest	40
choriocarcinoma cell	40
responsive genes	40
experimental animals	40
among patients	40
investigating whether	40
epithelial tissues	40
antioxidant status	40
often present	40
several months	40
proliferation assays	40
immunosorbent assay	40
minor salivary	40
induced higher	40
breast carcinoma	40
inflammatory signal	40
serum il	40
mean values	40
fluorescence microscopy	40
complex class	40
cells via	40
molecules cd	40
inducible expression	40
potassium channels	40
matrix metalloproteinases	40
molecule cd	40
house dust	40
severely impaired	40
cancer cases	40
double staining	40
including rheumatoid	40
like activity	40
phase reactant	40
exact role	40
directly interact	40
cells proliferate	40
resistance mechanisms	40
cytotoxic effect	40
control study	40
lavage fluid	40
six times	40
following treatment	40
might result	40
will present	40
transcriptional activity	40
hiv infection	39
different types	39
infiltrating macrophages	39
alternative activation	39
least months	39
common cold	39
susceptible mice	39
aluminium hydroxide	39
many others	39
remained largely	39
microarray technology	39
induced colitis	39
classically activated	39
mouse macrophage	39
cytometric bead	39
high grade	39
autologous monocytes	39
cytolytic activity	39
mhc molecules	39
higher blood	39
tnf alpha	39
also inhibit	39
total ige	39
antibody production	39
fed either	39
effective method	39
mapk pathway	39
molecules expressed	39
mean time	39
three times	39
vivo studies	39
sars cov	39
regulatory cd	39
evidence suggests	39
binding affinities	39
exchange chromatography	39
different tlr	39
remained unchanged	39
cardiac function	39
matrix metalloproteinase	39
regulatory phenotype	39
minor surgery	39
ist die	39
memory response	39
platelet activation	39
magnetic beads	39
increasing interest	39
infectious peritonitis	39
manganese superoxide	39
recently established	39
signaling molecules	39
tight junction	39
complement pathways	39
human cytokines	39
immune activation	39
mediated anti	39
cytotoxic activities	39
quantitative rt	39
mitochondrial enzyme	39
significantly downregulated	39
exhibited similar	39
among many	39
curative treatment	39
expression occurs	39
identify patients	39
tested positive	39
different pathways	39
remain largely	39
among strains	39
also increased	39
wide variety	39
highly expressed	39
epidermal growth	39
induce specific	39
enzymatic activity	39
pao fio	39
effects observed	39
many studies	39
induced activation	39
decreased expression	39
th effector	39
sensitive detection	39
und toxikologie	39
cesarean section	39
three proteins	38
der patienten	38
adjuvant properties	38
linked glycosylation	38
biological activities	38
probiotic bacteria	38
activated macrophage	38
using cytokine	38
inhibited il	38
stimulated pbmc	38
microbial components	38
vascular lesions	38
phagocytic cell	38
immunomodulatory effect	38
dimensional structure	38
lymphocyte infiltration	38
food intake	38
type lectin	38
acute inflammatory	38
activated complement	38
expanded cd	38
tight junctions	38
total igg	38
week intervals	38
normal range	38
experimental model	38
igm anti	38
greater effect	38
crc patients	38
probiotic strains	38
based vaccines	38
condition characterized	38
mobility group	38
cell balance	38
patients experiencing	38
obstructive pulmonary	38
inflammatory genes	38
analysis reveals	38
airway pressure	38
study evaluated	38
produce large	38
mucosal injury	38
intestinal mucosa	38
complement factors	38
proteins showed	38
derived peptide	38
evolutionary conserved	38
signalling molecule	38
kupffer cells	38
different bacterial	38
viral rna	38
mechanisms behind	38
many immune	38
gastrointestinal flora	38
small size	38
induced upregulation	38
serum tnf	38
clinical manifestations	38
blue dye	38
per kg	38
cell lung	38
adjuvant effect	38
proteins using	38
specifically bind	38
exact mechanisms	38
microvascular endothelial	38
represents one	38
cell numbers	38
apoptosis proteins	38
might contribute	38
reduced mhc	38
following acute	38
coli lipopolysaccharide	38
uric acid	38
trypanosoma brucei	38
map gene	38
dna laddering	38
treg cell	38
macrophage culture	38
part mediated	38
scientific community	38
cytotoxic effects	38
peptide pools	38
gene families	38
lps challenge	38
diseases caused	38
study showed	38
female mice	38
induced cytokine	38
primary function	38
protein purification	38
developed using	38
priming effect	38
will affect	38
usp expression	38
receptor binding	38
tcr repertoire	38
sequence information	38
completely abrogated	38
sle patients	38
similar results	38
neutrophil infiltration	38
dengue virus	38
mucosal barrier	38
two members	37
first generation	37
total number	37
mitochondrial dysfunction	37
equally well	37
covalent coupling	37
transcriptional regulation	37
cell wall	37
epithelial apoptosis	37
showed significantly	37
epithelial layers	37
rheumatic disease	37
clinical context	37
greater proportion	37
collected immediately	37
dna microarrays	37
double kos	37
differentially affect	37
mammalian host	37
growth advantage	37
early phase	37
responses following	37
median serum	37
mg per	37
protein induced	37
oligoadenylate synthetase	37
thereby allowing	37
standard assays	37
specific iga	37
terminal amino	37
vaccine candidates	37
uncomplicated malaria	37
first decade	37
capsid proteins	37
lps also	37
size exclusion	37
doublestranded rna	37
murine monoclonal	37
higher mrna	37
selectin gene	37
postoperative period	37
reporter genes	37
fetal brain	37
significantly correlated	37
soluble receptors	37
monocytes differentiate	37
crucial step	37
maturation marker	37
small cell	37
basement membrane	37
cells positive	37
cytokines increased	37
stress level	37
arginase activity	37
bile acid	37
first steps	37
cell size	37
optimal stimulation	37
adenosine receptor	37
system consists	37
takes place	37
neurodegenerative diseases	37
network model	37
within days	37
anaphylactic reactions	37
may fail	37
human macrophages	37
partially rescued	37
different antigens	37
cell density	37
human nk	37
either ifn	37
ige epitopes	37
dependent proliferation	37
interstitial lung	37
animals exhibited	37
induce apoptotic	37
cell responsiveness	37
remained unaltered	37
streptococcus pyogenes	37
normal functions	37
people worldwide	37
adoptive immunotherapy	37
via effects	37
tumour antigens	37
stained cells	37
rat serum	37
lactobacillus plantarum	37
proinflammatory chemokines	37
cell ifn	37
strong th	37
atopic eczema	37
anthropometric measurements	37
mg mg	37
ultrasound stimulation	37
cells stimulated	37
work provides	37
higher concentrations	37
oxidative damage	37
mutation leads	37
clinical characteristics	37
cytokine receptors	37
glial cells	37
peptides corresponding	37
superfamily members	37
feline infectious	37
maximum tnf	36
immunomodulatory cytokines	36
observed reduction	36
th dichotomy	36
monocytes produced	36
neutralizing antibodies	36
stress model	36
ms sera	36
essential processes	36
human mhc	36
research laboratories	36
demonstrate whether	36
complexes activate	36
arthritogenic properties	36
recurrent inflammation	36
care units	36
cell suspensions	36
better understanding	36
evaluated using	36
findings identify	36
femoral head	36
identified five	36
immunological characteristics	36
endotoxic shock	36
adaptor protein	36
streptococcal pyrogenic	36
including tnf	36
isotype switching	36
mammary epithelial	36
docking site	36
protein concentration	36
find new	36
important effector	36
clinic visits	36
experimental settings	36
levels comparable	36
soluble fraction	36
also applied	36
expressed significantly	36
associated molecules	36
pathway components	36
purified monocytes	36
women undergoing	36
complex mixtures	36
present work	36
isotonic saline	36
pfbm cells	36
cell immunoglobulin	36
statistically analysed	36
several cases	36
experimental models	36
lung fibrosis	36
oxygen consumption	36
three patients	36
ml range	36
immunological memory	36
earlier work	36
whereas others	36
atopic dermatitis	36
demonstrate binding	36
intracellular signaling	36
whether vitamin	36
facs analysis	36
given subcutaneously	36
dna repair	36
repeated times	36
suitable model	36
terminal regions	36
various species	36
detected among	36
acid change	36
major type	36
polymorphism results	36
critically important	36
infection will	36
found mainly	36
asthma control	36
sars coronavirus	36
specific marker	36
idiotypic antibody	36
reduced expansion	36
protein antigens	36
therapeutic approaches	36
esrd patients	36
nonspecific immune	36
markedly suppressed	36
recombinant form	36
coronavirus infection	36
incidence rate	36
many countries	36
immunomagnetic beads	36
independent way	36
percent predicted	36
transcriptional regulators	36
cells using	36
metastatic cancer	36
preliminary data	36
macrophages induce	36
increased local	36
proteins known	36
lung mucosa	36
key transcriptional	36
modulate cancer	36
effects include	36
dysfunction may	36
similar patterns	36
pathogenesis remains	36
antigens derived	36
urea levels	36
variants may	36
mainly cd	36
markers associated	36
second generation	36
buffy coats	36
borrelia spirochetes	36
tunel assays	36
mit einem	36
may associate	36
ldh release	36
cell dna	36
kg bw	36
mice demonstrate	36
year old	36
myeloid dc	36
using abc	36
approximately kda	36
systemic immunity	36
including breast	36
assay sensitivity	36
antitumour effects	36
supplementation increased	36
substantial differences	36
immunostimulatory effects	36
depends largely	36
single cell	36
like lesions	36
inhibitory receptor	36
may point	36
cell membranes	36
middle east	36
cervical ripening	36
pronounced differences	36
early diagnosis	36
cells circulating	36
fine mapping	36
expression without	36
quantitated using	36
nonlymphoid cells	36
exclusively expressed	36
epitope mapping	36
porcine reproductive	36
time periods	36
interacting protein	36
effectively controlled	36
gel permeation	36
term prognosis	36
immunosorbent assays	36
sertoli cell	36
clonal deletion	36
induce interleukin	36
insulin sensitivity	36
identify candidate	36
lethally irradiated	36
ep treatment	35
type iii	35
influenza viruses	35
upper airways	35
human parvovirus	35
using mutagenesis	35
following weeks	35
tlr pathways	35
parallel experiment	35
remains obscure	35
dramatically induced	35
hbv infection	35
cardiac arrest	35
induced regulatory	35
perform better	35
found frequently	35
peptide mhc	35
require confirmation	35
specific ab	35
network interactions	35
regulatory factor	35
major human	35
alkaline phosphatase	35
vein endothelial	35
two hours	35
basal cell	35
metabolic stress	35
receptor activation	35
stimulated expression	35
performed significantly	35
investigated serum	35
stimulate expression	35
ko phenotype	35
phenotype may	35
liver tissue	35
stimulation assay	35
systemic th	35
expressed lower	35
now report	35
proper th	35
threefold higher	35
chloride channels	35
complement resistance	35
maintaining homeostasis	35
permeation chromatography	35
poor survival	35
differentially activate	35
wide scan	35
achieved mainly	35
recently generated	35
molecules hla	35
autoantibodies directed	35
several inhibitors	35
acutely infected	35
flora including	35
urea concentrations	35
chikungunya virus	35
response revealed	35
monoclonal igm	35
receptor decreased	35
free university	35
malassezia sympodialis	35
position showed	35
revealed five	35
ion exchange	35
small molecule	35
burgdorferi sensu	35
three structurally	35
strong cytokine	35
safer alternative	35
coli infections	35
hinge region	35
corresponding recombinant	35
normal skin	35
phenotypic change	35
inactivated serum	35
human hla	35
mortality may	35
coculture system	35
successfully applied	35
low doses	35
lower surface	35
reverse transcription	35
well plates	35
produce type	35
see whether	35
aarhus university	35
approximately months	35
resonance analysis	35
asthmatic lung	35
culture cell	35
status might	35
also demonstrate	35
still significant	35
bacteria induced	35
extracellular signal	35
profound impact	35
growth hormone	35
plasmacytoid dc	35
turn results	35
humeral immunity	35
cells also	35
potential vaccine	35
inflammatory reactions	35
immobilization strategies	35
patients expressed	35
acute inflammation	35
soluble cd	35
subsequently determined	35
two additional	35
lysine residues	35
sugar metabolism	35
synovial fluid	35
chain fv	35
exact knowledge	35
autoimmune condition	35
mucosa samples	35
specific immunotherapy	35
adjuvant potential	35
novel affinity	35
early pregnancy	35
reticulum stress	35
also shown	35
increased cytotoxicity	35
around one	35
computer program	35
derived murine	35
disulfide bond	35
proteins used	35
postoperative infection	35
involving macrophages	35
significantly potentiated	35
different surgical	35
clinical malaria	35
hela cells	35
candidate autoantigen	35
ro ssa	35
subsequent challenge	35
gradient gel	35
generally low	35
excellent functional	35
construct based	35
potent inhibitor	35
mean percentage	35
three days	35
two recombinant	35
patients lacking	35
molecule ceramide	35
grade iii	35
will play	35
disease atopic	35
new vaccines	35
current standard	35
arthritic animals	35
dcs compared	35
unstimulated human	35
one among	35
tests will	35
surviving bacteria	35
undergoing periodic	35
specific igm	35
system allows	35
potential cross	35
effective treatment	35
pcr methods	35
way anova	35
cell clonotypes	35
high doses	35
international data	35
cell activity	35
well established	35
potential exists	35
lung diseases	35
lymphocyte population	35
predicted epitopes	35
gland development	35
combined data	35
also potentiated	35
surface mhc	35
lung lymph	35
erk pathways	35
cell signaling	35
neuroectodermal origin	35
volunteers using	35
protective dna	35
genes specific	35
steady state	35
coli infection	35
yeast malassezia	35
liver failure	35
largely unchanged	35
selected strains	35
even lower	35
whether gc	35
alternative splicing	35
enhanced ifn	35
yersinia enterocolitica	35
allergic individuals	35
molecular structures	35
colour flow	35
mucosal sites	35
five commercially	35
simultaneous expression	35
gain access	35
comparing patients	35
wt control	35
components like	35
diabetic vascular	35
influenza infection	35
alpha production	35
capsular polysaccharide	35
aureus strain	35
novel molecule	35
antigens within	35
cell replication	35
genetic polymorphisms	35
tcm formulas	35
gained increasing	35
elevated anti	35
directly applied	35
foreign antigen	35
standard statistical	35
cytokines used	35
purification procedure	35
expression showed	35
animals injected	35
readily detectable	35
cells acquire	35
partially prevented	35
angiotensin converting	35
receiving long	35
immunity via	35
cytokine gene	35
array screen	35
cr release	35
carbohydrate structures	35
first demonstrate	35
vitro experiments	35
sympodialis allergen	35
mainly induced	35
human factor	35
protein engineering	35
mhc complex	35
th day	35
allergen extracts	35
molecular repertoire	34
colonic biopsies	34
magnetically separated	34
distinct possibility	34
initiated activation	34
overt nephropathy	34
zeptomole range	34
responses target	34
cerebrospinal fluid	34
cycle time	34
simulated heliox	34
induced phagocytosis	34
recombinant pro	34
different commensal	34
isogenic serotype	34
separated cd	34
aerococcus viridans	34
sweden belongs	34
technique involving	34
cell directly	34
followed consecutively	34
tick vector	34
donors grown	34
totally inhibited	34
specific poly	34
place high	34
newly emerged	34
standard cr	34
considered significant	34
results demonstrates	34
control diet	34
collected seven	34
inhaled long	34
high demands	34
weeks fed	34
extensive sequence	34
mnsod needs	34
investigated immunological	34
binding efficiency	34
local autoantibody	34
technology will	34
iga molecules	34
reconstitution experiments	34
short term	34
five acutely	34
considerable less	34
increased mbl	34
spontaneous cytotoxicity	34
providing sensitive	34
coupling strategies	34
ncoder framework	34
prevented sendai	34
research activity	34
deficient compared	34
morphologically screened	34
antibodies along	34
pyrogenic exotoxin	34
mounted hbsag	34
mixtures occasionally	34
identical genotypes	34
inhibited kb	34
around calving	34
controlled based	34
probes retained	34
therefore examined	34
degradation processes	34
elevated mbl	34
interactions trigger	34
jak stat	34
system occurs	34
different coupling	34
via four	34
improve diseases	34
pneumococci produce	34
designated mala	34
upregulated cd	34
consistently low	34
natural autoantibodies	34
nonradioactive proliferation	34
last immunization	34
novozymes focuses	34
inhaled corticosteroid	34
tigr strain	34
higher abca	34
receptors seem	34
supports used	34
increasing dietary	34
hbsag contains	34
denaturing gradient	34
include components	34
constructed around	34
gut mucosa	34
juice urea	34
second class	34
immunologic similarity	34
immununized mice	34
asthma exacerbated	34
mt correlates	34
bacteria will	34
clonotype mapping	34
clinical symptoms	34
litter size	34
noncytopathic lymphocytic	34
strains weak	34
induction inhibited	34
vastly predominant	34
catalytic mechanism	34
measurable proliferation	34
physical examination	34
thereby becoming	34
inflammation involving	34
tlr involved	34
represent novel	34
different peptide	34
higher focus	34
specifically induced	34
enzyme complexes	34
target antigens	34
persistent normoalbuminuria	34
skin via	34
especially attracted	34
atopic allergy	34
significantly amplified	34
genetically constructed	34
roughly corresponding	34
protein followed	34
cytometry offers	34
lower prostaglandin	34
tnf levels	34
antiviral enzymes	34
assay described	34
mt decreased	34
mbl plays	34
promoting function	34
special focus	34
eight exons	34
levels independently	34
increasing urea	34
either seretide	34
microorganisms seems	34
investigated il	34
nearly pure	34
constitute part	34
numerically higher	34
expression mbl	34
lymphocytes play	34
sensitivity reaction	34
heterohybridoma technique	34
wt controls	34
cd adim	34
emerged clonotypes	34
ectopic germinal	34
immunity leads	34