This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.
| identifier | question |
|---|---|
| cord-253894-4u5yt7b7 | Assuming the latter scenario, what is the acquired new function of the poxvirus F16 homologs? |
| cord-252615-ajyv95pu | Human enterovirus 71 epidemics: what's next? |
| cord-258232-br4z3na6 | Do E- protein- containing vesicles have any biological functions? |
| cord-253024-b393ea2u | Are deletions contributing to the increased rates of recombination among the group F RNA+ mutants? |
| cord-263302-z5uhrta5 | This finding raises an intriguing question: Why does MHV use multiple pathways to regulate the expression of a single gene? |
| cord-259717-e8ljkv2y | ( i.e. do some infections make the gut more permissive to infection by additional viruses?). |
| cord-264359-m9j3pcj1 | ( Stoklosa and Latz, 1975)? |
| cord-260782-1lm8tzbc | A new papillomavirus of possums( Trichosurus vulpecula) associated with typical wartlike papillomas Routes of transmission of wobbly possum disease Immunohistochemical localization of macrophages and microglia in the adult and developing mouse brain Lactate dehydrogenase- elevating virus, equine arteritis virus, and simian hemorrhagic fever virus: a new group of positive- strand RNA viruses Lactate dehydrogenaseelevating virus: an ideal persistent virus? |
| cord-269866-3tpyj04y | How could these two products be translated from a single messenger RNA? |
| cord-255828-jrqdyfbg | The prion protein and lipid rafts Requirements for CEACAMs and cholesterol during murine coronavirus cell entry Novel G423S mutation of human alpha 7 nicotinic receptor promotes agonist- induced desensitization by a protein kinase C- dependent mechanism Raft membrane domains: from a liquid- ordered membrane phase to a site of pathogen attack Host- cell lipid rafts: a safe door for micro- organisms? |
| cord-255828-jrqdyfbg | The topology of GP4( http://mobyle.pasteur.fr/cgi-bin/portal.py?# forms::toppred; Claros and von Heijne, 1994) and the GPI anchor attachment signal( http://gpi.unibe.ch; Fankhauser and Mäser, 2005; Eisenhaber et al., 1998) were predicted using on- line programs available on the Bioinformatics Resource Portal( http://expasy.org/ tool). |
| cord-258379-v3lceirh | Are 3c- like proteins a general feature of coronaviruses? |
| cord-258379-v3lceirh | CK cells were mock- infected or infected with IBV and labeled with[? |
| cord-256769-flfycl7i | divergent role of CD46 cytoplasmic domains in T cell induced inflammation Complement and coagulation: strangers or partners in crime? |
| cord-271763-cual2qv4 | I!?), is also an internal sequence of basic amino acids that, in the case of MHV and IBV, lies on the immediate N- terminal side of the protease cleavage site( 6, 22). |
| cord-262347-ejhz9rra | Serum immune responses to the proteins of porcine reproductive and respiratory syndrome( PRRS) virus Analysis of RNA- dependent RNA polymerase structure and function as guided by known polymerase structures and computer predictions of secondary structure Determination of 5 0-leader sequences from radically disparate strains of porcine reproductive and respiratory syndrome virus reveals the presence of highly conserved sequence motifs Identification of neutralizing and nonneutralizing epitopes in the porcine reproductive and respiratory syndrome virus GP5 ectodomain Survival of porcine reproductive and respiratory syndrome virus in houseflies Evaluation of mosquitoes, Aedes vexans, as biological vectors of porcine reproductive and respiratory syndrome virus Genetic manipulation of arterivirus alternative mRNA leader- body junction sites reveals tight regulation of structural protein expression Regulation of relative abundance of arterivirus subgenomic mRNAs Nidovirus transcription: how to make sense …? |
| cord-262574-gu0930s3 | Escape from immune destruction by the host through shedding of surface antigens: Is this a characteristic shared by malignant and embryonic cells? |
| cord-262574-gu0930s3 | Forty microliters of labeled whole cell extracts( 3H or? |
| cord-275234-t6e7vr9y | R( lane 1) represents purified[? |
| cord-284968-eymvj6k3 | ( Okuno et a,?. |
| cord-274122-n9jnu2ah | deubiquitinase inhibitors blocks SARS virus replication Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex Deubiquitination, a new function of the severe acute respiratory syndrome coronavirus papain- like protease? |
| cord-266617-z8uecyl6 | Origins of genes:"big bang"or continuous creation? |
| cord-266617-z8uecyl6 | Positive selection or free to vary? |
| cord-272050-0u62j7nj | For example, at what frequency is p88 used for cis- preferential replication of RNA1? |
| cord-272050-0u62j7nj | What does cis- preferential requirement for p88 in RNA1 replication means for RCNMV? |
| cord-289712-w1y0lc5c | Selection of genetica& wmrked IA? cells. |
| cord-275348-jna496x7 | How can we explain the greater potency of the single- cycle vectors relative to replication- competent vectors given i.m.? |
| cord-283998-whwksoxt | The latter is a complex of several noncovalently linked subunits( MW 2.5- 3.3 x lo'? |
| cord-289248-6mx4o0eb | have we learned? |
| cord-290282-oxyzndsj | The nucleolus- a gateway to viral infection? |
| cord-293790-7hyelm88 | Given the involvement of autophagy at the site of replication of other positive- stranded RNA viruses, are the autophagy proteins or structure involved in HCV replication? |
| cord-296416-q0rsfzgw | In vitro veritas? |
| cord-268139-tgpsu4qz | Do the deletion and point mutations change the nature of nsp1-protein interactions? |
| cord-268139-tgpsu4qz | What function does this domain have during MHV RNA synthesis? |
| cord-268139-tgpsu4qz | Why is the nsp1 amino- terminus required for MHV replication? |
| cord-298847-szezd2vb | A light- and electronic- microscopic study Susceptibility of murine CNS to OC43 infection Disruption of type IV intermediate filament network in mice lacking the neurofilament medium and heavy subunits Does viral disease underlie ALS? |
| cord-299976-36r794ow | The prevalence of types I and II feline coronavirus infections in cats Characterization of monoclonal antibodies against feline infectious peritonitis virus type II and antigenic relationship between feline, porcine, and canine coronaviruses Expression of feline infectious peritonitis coronavirus antigens on the surface of feline macrophage- like cells Detection of feline coronavirus in captive Felidae in the USA Reversal of the progression of fatal coronavirus infection in cats by a broad- spectrum coronavirus protease inhibitor Broad- spectrum antivirals against 3C or 3C- like proteases of picornaviruses, noroviruses, and coronaviruses Potent inhibition of feline coronaviruses with peptidyl compounds targeting coronavirus 3C- like protease Broad- spectrum inhibitors against 3C- like proteases of feline coronaviruses and feline caliciviruses Feline infectious peritonitis: still an enigma? |
| cord-296364-7rp60d2m | A polycistronic mRNA specified by the coronavirus infectious bronchitis virus Is green fluorescent protein toxic to the living cells? |
| cord-287777-ogs4mq0v | Promyelocytic leukemia protein mediates interferon- based anti- herpes simplex virus 1 effects HAUSP as a therapeutic target for hematopoietic tumors PML bodies: a meeting place for genomic loci? |
| cord-287777-ogs4mq0v | latently infected B lymphocyte lines: association with deubiquitinating enzymes Molecular recognition of p53 and MDM2 by USP7/ HAUSP Unique and conserved features of genome and proteome of SARS- coronavirus, an early split- off from the coronavirus group 2 lineage Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex Transcription under the control of nuclear Arm/[beta]-catenin Deubiquitination, a new function of the severe acute respiratory syndrome coronavirus papainlike protease? |
| cord-307354-dkwcheu0 | virion host shutoff RNase is enabled by pUL47 and an embedded nuclear export signal and defines the sites of degradation of AU- rich and stable cellular mRNAs Viral phosphodiesterases that antagonize doublestranded RNA signaling to RNase L by degrading 2- 5A Human genome- wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis Herpes simplex virus virion host shutoff protein: immune evasion mediated by a viral RNase? |
| cord-286060-92lazxd7 | Infected cells were labeled with[? |
| cord-286060-92lazxd7 | Neither of these treatments released any detectable pp60 from the PlOO fraction( data not shown), suggesting the possibility that pp60 was an integral membrane protein, To rigorously examine this possibility, the PlOO fraction was treated with alkali which removes membrane- associated proteins but not the integral membrane proteins( 4, I?'). |
| cord-293248-8vtd9e4n | Virus infections of the gastrointestinal tract of poultry TBP, a universal eukaryotic transcription factor? |
| cord-309015-t5v2sjus | Enveloped viruses: a common mode of membrane fusion? |
| cord-305564-dj3vj4tk | The severe acute respiratory syndrome coronavirus 3a is a novel structural protein SARS- CoV replication and pathogenesis in an in vitro model of the human conducting airway epithelium Unique and conserved features of genome and proteome of SARS- coronavirus, an early split- off from the coronavirus group 2 lineage A doubleinactivated whole virus candidate SARS coronavirus vaccine stimulates neutralising and protective antibody responses Is there an ideal animal model for SARS? |
| cord-313906-fh85fzq9 | A system for functional analysis of Ebola virus glycoprotein A distinct lineage of influenza A virus from bats New world bats harbor diverse influenza A viruses Distribution of neuraminidase in Arthrobacter and its purification by affinity chromatography Genetic characterization and susceptibility on poultry and mammal of H7N6 subtype avian influenza virus isolated in Japan in 2009 Mass extinctions, biodiversity and mitochondrial function: are bats'special'as reservoirs for emerging viruses? |
| cord-280795-wtrt13ij | Is it possible that a protein domain can participate in RNA replication while it is also responsible for the removal of 5′ γ- phosphate from the nascent RNA to allow cap structure formation? |
| cord-280795-wtrt13ij | Would it be possible that alanine substitution at Q826 affects not only the enzymatic activity but also the protein stability? |
| cord-300884-rqfxe0x1 | The papain- like protease from the severe acute respiratory syndrome coronavirus is a deubiquitinating enzyme Full- length human immunodeficiency virus type 1 genomes from subtype C- infected seroconverters in India, with evidence of intersubtype recombination A biochemical genomics approach for identifying genes by the activity of their products Localization of an RNA- binding domain in the nucleocapsid protein of the coronavirus mouse hepatitis virus Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure Discovery of an RNA virus 3′→5′ exoribonuclease that is critically involved in coronavirus RNA synthesis Characterization of the coronavirus M protein and nucleocapsid interaction in infected cells Characterization of N protein selfassociation in coronavirus ribonucleoprotein complexes Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites Nidovirus transcription: how to make sense …? |
| cord-311255-zaa8i9vh | recommendations of the Nomenclature Committee on Cell Death Putative partners in Bax mediated cytochrome- c release: ANT, CypD, VDAC or none of them? |
| cord-303238-us3dybue | Why does MHV PLP2 require membrane association for proteolytic processing of the PLP2 cleavage site? |
| cord-300372-h5g4z8ts | and T(H)2 inflammation in the pathogenesis of bronchial asthma Influenza-time to target the host? |
| cord-320590-irybhp4j | Why does ILTV activate host Src to achieve these opposite functions? |
| cord-285869-jwflooop | Could nsp4-N258 T be localizing to mitochondria in error resulting in reduced DMV assembly? |
| cord-285869-jwflooop | Or is there a mitochondrial phase in MHV replication whose progression is inhibited by the nsp4-N258 T substitution? |
| cord-300810-a1skdp67 | 55, 158-l 62 Is the acetylcholine receptor a rabies virus receptor? |
| cord-300810-a1skdp67 | Why are certain neurons not permissive for AvOl? |
| cord-315069-xo4mbxei | ( Jones e? al., 1990). |
| cord-302486-z36hcvrx | Negative staining method for high resolution electron microscopy of viruses Detection of prions in blood Multiplex realtime quantitative RT- PCR assay for hepatitis B virus, hepatitis C virus, and human immunodeficiency virus type 1 DNA microarrays of the complex human cytomegalovirus genome: profiling kinetic class with drug sensitivity of viral gene expression A role for arrays in clinical virology: fact or fiction? |
| cord-322084-gkg1059v | In''PCR Protocols''( M. A. Innis, is 31 kb, whereas genomic DI RNA is only 2.6 kb Replication kb from the 3-end of genome, respectively, whereas our and plaque formation of mouse hepatitis virus( MHV-2) in mouse experimental intergenic regions were located only 1.2 kb cell line DBT culture Investi- RNA has multiple intergenic regions, whereas genomic gation of the control of coronavirus subgenomic mRNA transcription by using T7-generated negative- sense RNA transcripts Mechanism of coronavirus transcripbetween the amounts of subgenomic DI RNA and real tion: Duration of primary transcription initiation activity and effect of MHV mRNAs? |
| cord-322904-9mta0aem | How do animal DNA viruses get to the nucleus? |
| cord-303497-s3zs1oxf | Labeling of 113/ Ho protein did not increase if the? |
| cord-303497-s3zs1oxf | Next, protein synthesis has been studied by incorporation of[? |
| cord-351197-xv6ymc4l | What is for dinner? |
| cord-254747-vox5xsgd | Athmer et al., 2017)? |
| cord-254747-vox5xsgd | How does nsp15 mediate the evasion of host sensors? |
| cord-254747-vox5xsgd | How does the EndoU activity of nsp15 alter the fate of dsRNA? |
| cord-254747-vox5xsgd | How is this EndoU activity regulated to avoid unwanted cleavage events? |
| cord-254747-vox5xsgd | What is the natural target of EndoU? |
| cord-333525-67bbmo4m | the host cell species barrier Genetic evidence for a structural interaction between the carboxy termini of the membrane and nucleocapsid proteins of mouse hepatitis virus Coronaviridae Luxury at a cost? |
| cord-294260-g410mavp | How is it determined at which B- TRS the synthesis of the( −) strand RNA stalls, leading to duplex formation with an L- TRS? |
| cord-294260-g410mavp | The stability of the duplex between sense and antisense transcription- regulating sequences is a crucial factor in arterivirussubgenomic mRNA synthesis Nidovirus transcription: how to make sense …? |
| cord-294260-g410mavp | With respect to viruses with multiple SG RNAs, why are some RNAs made in larger amounts than others? |
| cord-353748-y1a52z8e | Bacteriocins-a viable alternative to antibiotics? |
| cord-342901-ca2xxkb2 | So what are we to make of all the proposed ITAFs for PV and other closely related enteroviruses? |
| cord-342901-ca2xxkb2 | virus( HAV) proteinase 3C inhibits HAV IRES- dependent translation and cleaves the polypyrimidine tract- binding protein Polypyrimidine tract binding protein functions as a negative regulator of feline calicivirus translation Stress granules and cell signaling: more than just a passing phase? |
| cord-329625-hx2rsi91 | The multifunctional nucleolus Cell cycle dependent localisation of the coronavirus nucleocapsid protein Trafficking mechanism of West Nile( Sarafend) virus structural proteins Visualization of intracellular transport of vesicular stomatitis virus nucleocapsids in living cells Are nidoviruses hijacking the autophagy machinery? |
| cord-329625-hx2rsi91 | What is new in the nucleolus? |
| cord-329625-hx2rsi91 | the nucleolus-a gateway to viral infection? |
| cord-316134-lkd2mj27 | ( Zhou et al., 2018), and vice versa? |
| cord-316134-lkd2mj27 | Are there effects from other viral components? |
| cord-316134-lkd2mj27 | Considering the opposing effects on PEDV replication of N proteins from TGEV, an older virus emerging prior to PEDV, and PDCoV, a newly emerged one, is it possible that nucleocapsid proteins could act as one of the factors in permitting or limiting emergence of enteric swine CoVs? |
| cord-316134-lkd2mj27 | For example, in the context of co- infection, in which all other viral components are present, what would be the net outcomes on replication kinetics of each virus? |
| cord-266861-t5h133lp | Although there is preliminary evidence as discussed above, the most important question is what is the in vivo significance of PVEERs and their relative contribution to infection? |
| cord-266861-t5h133lp | Finally, are there additional unidentified PVEERs that contribute to this newly appreciated means of viral infection? |
| cord-266861-t5h133lp | Gas6, are ligands for the Tyro 3/ Axl family of receptor tyrosine kinases cDNA cloning of a mouse mammary epithelial cell surface protein reveals the existence of epidermal growth factor- like domains linked to factor VIII- like sequences Japanese Encephalitis virus infection initiates endoplasmic reticulum stress and an unfolded protein response Is the TAM receptor Axl a receptor for lymphocytic choriomeningitis virus? |
| cord-266861-t5h133lp | Is any cell signaling involved in these events? |
| cord-266861-t5h133lp | Is there a mechanism of direct internalization that results in productive infection? |
| cord-266861-t5h133lp | Second, how is PtdSer being incorporated into viral envelopes and does it matter which membrane the envelope is derived from? |
| cord-266861-t5h133lp | Third, what is the mechanism mediating PVEER- dependent entry? |
| cord-266861-t5h133lp | an immunohistochemical and ultrastructural study TIM-1 induces T cell activation and inhibits the development of peripheral tolerance Viral apoptotic mimicry: an immune evasion strategy developed by the hepatitis B virus? |
| cord-305143-mqd4ioj4 | Do they function in host interaction? |
| cord-305143-mqd4ioj4 | Do they possess as of yet undiscovered, but shared protein domains? |
| cord-305143-mqd4ioj4 | Do they result in altered pathology or clinical symptoms? |
| cord-305143-mqd4ioj4 | Our automated approach provides a starting point for the systematic computational and experimental study of these species- and strain- specific proteins- studies, which eventually will provide answers to such questions as: Are these species- and strain- specitic proteins essential under certain conditions? |
| cord-305143-mqd4ioj4 | Similarly, what would be the consequence of adding a Cterminal GlyL_C domain to the gL protein of VZV( which contains one Herpes_UL1 domain), and so making it similar to the gL protein found in HSV-1 and HSV-2( which has a Herpes_UL1--GlyL_C architecture)? |
| cord-305143-mqd4ioj4 | This raises the question-are such share named truly justified for proteins composed of unrelated domains? |
| cord-325179-gsf8ad65 | 1000 kIU Trasylol( Mobay Chemical Co., New York, N. Y.), mixed, and triplicate samples were removed for determination of pretreatment acid- precipitable 3H and? |
| cord-325179-gsf8ad65 | A more direct approach to the potential problem of randomization involved metabolic labeling of T- ag with[? |
| cord-325179-gsf8ad65 | Analysis of the sample before and after cation exchange revealed that most of the? 3labeled material had been removed from the hydrolysate( Table 4). |
| cord-325179-gsf8ad65 | Filters were redried, then assayed for 3H and? |
| cord-325179-gsf8ad65 | Infected cells were starved in glucose- free E- MEM from 20.5 to 21 hr p.i., then labeled for 3 hr using 25& i/ ml[? S]methionine or 100& i/ ml |
| cord-325179-gsf8ad65 | SACI- bound immune complexes were then resuspended in TBS and treated with 0, 0.5, 1.0, 1.5, or 2.0 mg of mixed giycosidaaes for 15 hr at 37O. Aliquots of each sample were removed before and after treatment, TCA precipitated, and analyzed for? |
| cord-325179-gsf8ad65 | The small amount of? |
| cord-325179-gsf8ad65 | Therefore, we examined the absolute and relative incorporation of[? |
| cord-325179-gsf8ad65 | To analyze the effect of EndoH, SV40infected cells were labeled with[? |
| cord-325179-gsf8ad65 | and? |