trigram

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trigram frequency
as well as457
the presence of427
results suggest that359
we found that295
the effect of289
in this study279
in order to279
these results suggest267
the role of262
the number of254
in the presence237
the expression of232
the present study218
the effects of202
one of the192
in the present182
graduate school of173
in the brain170
involved in the166
the development of166
the formation of162
cells in the154
suggest that the150
to investigate the141
in response to140
central nervous system140
results indicate that136
to determine the135
school of medicine131
we show that131
role in the129
of this study128
was used to124
neurons in the123
the use of122
been shown to117
in cf patients116
it has been116
this study was114
the absence of114
based on the114
we investigated the113
compared to the112
an important role111
in patients with110
the regulation of110
we examined the109
study was to108
to study the108
changes in the106
an increase in105
angelica tenuissima nakai104
due to the104
the plasma membrane102
in vitro and102
data suggest that101
the level of99
has been shown98
in the absence98
have shown that97
observed in the96
these results indicate95
in addition to94
was observed in93
the central nervous93
on the other93
the aim of93
found that the92
important role in92
were used to90
can be used90
the other hand90
in the hippocampus89
part of the89
in cystic fibrosis87
is involved in87
with cystic fibrosis86
green fluorescent protein85
as compared to85
a number of85
be involved in85
and in vivo85
a role in85
expressed in the83
patients with cf82
showed that the81
a variety of81
and in the81
the amount of80
the activation of78
expression of the78
analysis of the78
we conclude that78
has not been77
increase in the77
vitro and in77
airway epithelial cells76
is associated with76
in contrast to75
well as the74
show that the73
we have previously73
our results suggest71
in the regulation71
nsp and nsp71
be used to71
the cells were71
the rate of71
the activity of70
the function of70
of cf patients70
the treatment of70
results show that69
contribute to the69
to determine whether69
dorsal accessory calyx68
the importance of68
hek t cells68
a total of68
aim of this67
to understand the67
found to be67
of the brain67
university of tokyo67
is one of67
according to the66
related to the66
the control of66
the mechanism of65
as a result65
the end of65
department of physiology65
is known to65
associated with the65
in terms of64
children with cf64
the dorsal accessory64
known to be64
these data suggest64
findings suggest that64
there was no64
the cell surface64
of the protein64
we hypothesized that63
the majority of63
region of the62
a decrease in62
in the rat61
effect on the61
used as a61
the influence of61
indicate that the60
the ability of60
structure of the59
are involved in59
there is a59
black flying fox59
the most common59
activation of the59
the cystic fibrosis59
were treated with58
to examine the58
a bp kenyon58
in the adult58
play a role58
in the central58
expression in the58
to elucidate the58
may contribute to57
neural stem cells57
is characterized by57
most of the57
bp kenyon cells56
the study of56
but not in56
in which the56
found in the56
is known about56
to evaluate the56
in the cns56
is required for55
to identify the55
were infected with55
properties of the55
end of the55
role of the55
in the cf55
the impact of54
of angelica tenuissima54
little is known54
the replication of54
a combination of54
the induction of54
the spinal cord54
is essential for53
to be a53
data not shown53
we showed that53
function of the52
the interaction of52
was found to52
in the control52
we have shown51
we analyzed the51
by means of51
such as the51
compared with the51
had no effect51
no effect on51
significant increase in51
shown to be51
of the virus50
the onset of50
as shown in50
play an important50
the course of50
of the disease50
consistent with the50
was associated with50
are associated with50
activity of the50
cells of the49
in the same49
and found that49
activity in the49
was used as49
the relationship between49
we have developed49
the basis of49
respiratory syncytial virus49
resulted in a49
the levels of49
of the gfp49
a significant increase48
were able to48
for h at48
the identification of48
decrease in the48
supported by the48
suggesting that the48
of the cell48
the kinetics of48
these findings suggest48
for min at48
for the treatment48
the pathogenesis of47
the percentage of47
understanding of the47
to assess the47
university graduate school47
to that of47
the involvement of47
in the developing46
science and technology46
the structure of46
the surface of46
with respect to46
of the most46
this study we46
the existence of46
for the first46
at room temperature46
was determined by45
respiratory syndrome coronavirus45
patients with cystic45
the release of45
member of the45
institute of technology45
the frequency of45
has been reported45
of the two45
we used a45
there were no45
we studied the45
present in the44
the purpose of44
of the membrane44
demonstrated that the44
plays an important44
were observed in44
is able to44
the process of44
to analyze the43
the production of43
cells were infected43
we observed that43
is thought to43
national institute of43
in the ca43
have been shown43
to determine if43
the fact that43
the increase in43
may be a42
compared to control42
the distribution of42
responsible for the42
presence of a42
the ability to42
the molecular mechanisms42
is an important42
are known to42
the analysis of42
there was a42
in situ hybridization41
a member of41
was supported by41
a series of41
the results of41
at the end41
cf patients with41
we developed a41
in combination with41
university school of41
our results indicate40
mutations in the40
quality of life40
the case of40
when compared to40
severe acute respiratory40
cystic fibrosis foundation40
brain science institute40
in the hippocampal40
to characterize the40
acute respiratory syndrome40
the interaction between39
here we show39
before and after39
this work was39
is regulated by39
will be discussed39
were found in39
data show that39
a result of39
well as in39
the lack of39
of cystic fibrosis39
it is possible39
associated with a39
on the basis39
formation of the39
the generation of39
in the development39
the hypothesis that38
were incubated with38
with cf and38
of the same38
we propose that38
a and b38
the inhibition of38
difference in the38
in the spinal38
thought to be38
suggests that the38
the mechanisms of38
the extent of38
for this purpose38
in this work38
did not affect38
used to determine38
of the human38
is mediated by38
the first time38
appears to be37
depending on the37
in the cell37
of the viral37
a range of37
results showed that37
in comparison to37
the binding of37
all of the37
western blot analysis37
two types of37
we hypothesize that37
in the first37
of the patients37
in the dorsal37
in living cells37
effect of the37
between the two36
of the central36
in the mouse36
were found to36
our results show36
we observed a36
gene expression in36
characterization of the36
were obtained from36
to test the36
the accumulation of36
the time of36
the contribution of36
control of the36
shown that the36
we also found36
is expressed in36
as part of35
than in the35
in the number35
have been reported35
hepatitis b virus35
differences in the35
of the cells35
atomic force microscopy35
have demonstrated that35
transmembrane conductance regulator35
results demonstrate that35
was detected in35
the proportion of35
flying fox cells35
the addition of35
the application of35
the endoplasmic reticulum35
be related to35
change in the34
this study is34
presence of the34
the concentration of34
we found a34
in the case34
here we report34
of patients with34
was used for34
revealed that the34
members of the34
the changes in34
as described above34
added to the34
is important for34
cells transfected with34
bronchial epithelial cells34
to explore the34
were transfected with33
years of age33
astrocytes in the33
were performed in33
a role for33
located in the33
is based on33
was performed using33
purpose of this33
was added to33
the results suggest33
studies have shown33
cf lung disease33
the university of33
indicating that the33
in the nucleolus33
examined the effects33
live cell imaging33
of the cf33
that of the33
we demonstrate that33
on the cell33
detected in the33
effects on the32
adult cf patients32
large number of32
the a bp32
of the cftr32
the change in32
were carried out32
components of the32
have been used32
been reported to32
each of the32
the apical membrane32
and that the32
at the time32
present study was32
wide range of32
to be involved32
on the surface32
effects of the32
than that of32
dependent on the32
some of the32
only in the32
the loss of32
a function of32
to clarify the32
did not show32
which is a32
in the expression32
is consistent with32
have previously shown32
we used the32
were analyzed by32
herpes simplex virus32
cystic fibrosis transmembrane32
similar to the31
to test this31
correlated with the31
we report that31
are consistent with31
h k me31
at the same31
national institute for31
that can be31
sod g a31
the cerebral cortex31
previously shown that31
has been proposed31
spinal cord injury31
we have found31
their ability to31
we find that31
increase of the31
expression levels of31
was applied to31
proteins in the31
to play a31
was carried out31
in relation to31
data indicate that31
fibrosis transmembrane conductance31
regulation of the31
we have recently30
analysis revealed that30
the efficacy of30
we measured the30
in vivo and30
be due to30
applied to the30
acts as a30
at least one30
increased in the30
a wide range30
adults with cf30
the age of30
due to a30
our data suggest30
we demonstrated that30
under the control30
as a function30
size of the30
cells were transfected30
been used to30
we have used30
the efficiency of30
obtained from the30
the size of30
were used as30
for the development30
a large number30
we present a30
in lung function29
surface of the29
leads to a29
key role in29
significant difference in29
were cultured in29
in the membrane29
we sought to29
indicated that the29
in comparison with29
that in the29
molecular dynamics simulations29
we suggest that29
a crucial role29
influenza a virus29
regions of the29
was confirmed by29
we tested the29
in mammalian cells29
of these cells29
significant decrease in29
t cells were29
derived from the29
we have identified29
results indicated that29
the dentate gyrus29
airway surface liquid29
has been used29
the magnitude of29
also found that29
mechanism of action29
we evaluated the29
shown in figure29
better understanding of29
we have investigated29
we are currently29
study of the29
a key role29
p and p28
c bl j28
of neurons in28
to the cell28
different types of28
is responsible for28
japan we have28
were used for28
astrocytes and microglia28
gaba a receptors28
demonstrate that the28
to measure the28
a significant decrease28
component of the28
study is to28
it is not28
the dynamics of28
was performed in28
to better understand28
as measured by28
as a potential28
results in a28
mechanism by which28
have developed a28
we have studied28
was found in28
the possibility that28
cells were incubated28
identified in the28
high levels of28
morbidity and mortality28
as described previously28
will be presented28
previously reported that27
the gfp gene27
in children with27
an increase of27
cd t cells27
development of the27
riken brain science27
by western blot27
which can be27
was expressed in27
japan in the27
depends on the27
the need for27
the apical surface27
the nervous system27
thermo fisher scientific27
receptors in the27
used for the27
department of anatomy27
prior to the27
the ratio of27
known about the27
could not be27
have not been27
was assessed by27
the cell membrane27
is the most27
important roles in27
form of the27
total number of27
not affect the27
a model of27
that there is27
by flow cytometry27
to be the26
levels in the26
an in vitro26
these results demonstrate26
as a model26
the total number26
insight into the26
the localization of26
to compare the26
to the cells26
led to the26
inhibition of the26
g a mice26
the amplitude of26
seen in the26
in the study26
vesicular stomatitis virus26
the stability of26
in the nucleus26
of the p26
work was supported26
allowed us to26
is crucial for26
in the cerebellum26
in agreement with26
to interact with26
similar to that26
the ca region26
in the pathogenesis26
as previously described26
are expressed in26
vaccinated with chadox26
no significant difference26
we have demonstrated26
activation in the26
we were able26
were exposed to26
results suggested that26
mechanism of the26
but not the26
in the lung26
required for the26
characterized by a26
the properties of25
crucial role in25
the substantia nigra25
has been suggested25
to test whether25
corresponding to the25
to investigate whether25
investigated the effects25
cells infected with25
was shown to25
of the a25
are able to25
been shown that25
the combination of25
in the plasma25
may play a25
examined the effect25
we have been25
the hippocampus of25
we examined whether25
of the n25
included in the25
addition to the25
to this end25
to address this25
stimulation of the25
were measured by25
relative to the25
learning and memory25
investigated the effect25
cells treated with25
recent studies have25
it was shown25
insights into the25
of cftr in25
this effect was25
cells were then25
none of the25
supported by nih25
the degree of25
in the primary25
in cf cells25
and the other25
side of the25
we did not25
department of physics24
of the three24
to the plasma24
time course of24
compared to wt24
the gfp substrate24
previous studies have24
cystic fibrosis patients24
in a single24
roles in the24
compared to those24
cf patients and24
the inflammatory response24
we will discuss24
cells were washed24
neuronal activity in24
reported to be24
used to study24
induced by the24
of more than24
are thought to24
in presence of24
it is well24
of action of24
department of molecular24
of the study24
of the host24
expression of a24
a group of24
is critical for24
of glial cells24
appear to be24
is due to24
followed by a24
a critical role24
leads to the24
this suggests that24
based on a24
use of the24
the control group24
is caused by24
reactive oxygen species24
contrast to the24
molecular mechanisms of24
the prevalence of24
necessary for the24
is necessary for24
mediated by the24
by the presence24
due to its24
cell death in23
fold increase in23
was inhibited by23
we investigated whether23
based on these23
the lungs of23
was to investigate23
no significant differences23
was also observed23
we performed a23
the detection of23
highly expressed in23
the culture medium23
response in the23
out of the23
did not change23
in the striatum23
the study period23
have found that23
experiments were performed23
cells were seeded23
human bronchial epithelial23
hela cells were23
cells were fixed23
analysis was performed23
the r domain23
and may be23
by using a23
were detected in23
of a single23
of purkinje cells23
it is important23
shown in fig23
hepatitis c virus23
was to determine23
organization of the23
in the human23
the olfactory bulb23
in the treatment23
the duration of23
a better understanding23
development of a23
there is no23
focused on the23
suggested that the23
an inhibitor of23
c bl mice23
used in the23
a set of23
cells were treated23
is dependent on23
cloned into the23
was able to23
the green fluorescent23
basis of the23
is a key23
no difference in23
of astrocytes in23
a reduction in23
the wild type23
of microglia in23
may lead to23
the sequence of22
in our study22
and inflammatory monocytes22
and function of22
the appearance of22
analysis showed that22
middle east respiratory22
been reported in22
of the s22
in line with22
these results suggested22
modulation of the22
has also been22
the density of22
type i interferon22
supported by cff22
the interaction with22
correlation between the22
the maintenance of22
the brain of22
more than one22
the rat brain22
gaba a receptor22
we compared the22
under these conditions22
findings indicate that22
in the auditory22
during the first22
type i ifn22
of a novel22
leading to the22
allow us to22
the possibility of22
we determined the22
or in the22
the risk of22
of the dna22
is important to22
were performed using22
a significant difference22
was shown that22
in the airway22
we have also22
of the cellular22
of infected cells22
the cut site22
human airway epithelial22
half of the22
in the olfactory22
were prepared from22
we focused on22
as described in22
department of chemistry22
in the two22
to the cf22
be used as22
the roles of22
the innate immune22
of the airway22
in real time22
the modulation of22
remains to be22
east respiratory syndrome22
the molecular mechanism22
distribution of the22
plays a role22
to the development22
h ak ub22
was performed to22
of the hippocampus21
rnai suppressor activity21
for at least21
with or without21
the range of21
this work is21
porcine epidemic diarrhea21
did not differ21
cells were cultured21
to the nucleus21
glial cells in21
cells compared to21
is used to21
information on the21
led to a21
neurons of the21
in hek t21
to improve the21
sox cut sites21
be able to21
department of biophysics21
is supported by21
a mouse model21
in the early21
critical role in21
at the cell21
and on the21
is not clear21
on the contrary21
contributes to the21
to reveal the21
and analyzed by21
in the mammalian21
its ability to21
innate immune response21
of cf lung21
the design of21
sequence of the21
the potential of21
the mushroom body21
to the control21
in cell culture21
it was found21
kindly provided by21
of neural stem21
in hela cells21
formation of a21
we have examined21
are responsible for21
of the pro21
in regulation of21
academy of sciences21
not affected by21
that has been21
of the enzyme21
our understanding of21
in the cortex21
is a member21
the prefrontal cortex21
has been demonstrated21
in the visual21
is a potent21
spinal cord of21
of type i21
be associated with21
the in vivo21
with chadox mers21
and it is21
was no significant21
in astrocytes and21
response to the21
animals vaccinated with21
by measuring the21
institute of neuroscience21
of the rat21
primary cultures of21
in the lungs21
of the main21
is well known20
this work we20
the orf gene20
position of the20
as determined by20
bound to the20
dynamics of the20
of the present20
was found that20
also known as20
of the cns20
number of reads20
microglia in the20
increased expression of20
in the formation20
in the substantia20
cleavage of the20
may be involved20
of the lipid20
we report the20
was replaced with20
be used for20
to changes in20
the molecular basis20
the basal ganglia20
to have a20
cells were grown20
conclude that the20
was induced by20
in the literature20
to those of20
in the cells20
confocal laser scanning20
this type of20
to increase the20
in the second20
of the target20
as assessed by20
the pathophysiology of20
was observed at20
stem progenitor cells20
act as a20
state of the20
expression of cftr20
we speculate that20
the progression of20
we aimed to20
not well understood20
was measured by20
to the apical20
considered to be20
the results showed20
in the left20
in cf and20
the increase of20
the administration of20
were divided into20
data demonstrate that20
interaction with the20
compared to controls20
was increased in20
neutrophils and inflammatory20
as a control20
found that a20
play important roles20
in the right20
the potential to20
of the first20
bv or mlt20
we previously reported20
were expressed in20
protein in the20
increased the number20
the characterization of20
close to the20
is possible to20
of gaba a20
resulting in the20
nucleus of the20
aim of the20
by confocal microscopy20
posterior lateral protocerebrum20
the same time20
responses in the20
molecular mechanism of19
institute for physiological19
to estimate the19
extract of angelica19
function in the19
mrna and protein19
cf and non19
the intensity of19
even in the19
the posterior lateral19
a l p19
part of a19
u r n19
lead to the19
have been identified19
to the same19
level of the19
o u r19
the occurrence of19
genes involved in19
small number of19
and incubated at19
to confirm the19
increased levels of19
have reported that19
with a high19
vero e cells19
washed with pbs19
formation in the19
at least in19
o o f19
dynamic light scattering19
l p r19
we generated a19
we confirmed that19
in this process19
the action of19
and of the19
compared to wild19
and stained with19
p x r19
neural progenitor cells19
better understand the19
r o o19
is capable of19
project to the19
to the membrane19
might be involved19
significantly reduced in19
the present work19
red fluorescent protein19
tokyo metropolitan institute19
n a l19
of chikungunya virus19
p r o19
and at the19
patients with a19
is the first19
functions in the19
the decrease in19
and activation of19
the location of19
short circuit current19
result suggests that19
belongs to the19
p r e19
were collected from19
department of pharmacology19
serve as a19
are essential for19
course of the19
our results demonstrate19
antiviral activities of19
binding to the19
of the er19
intensity of the19
of the major19
determine whether the19
of membrane proteins19
these results show19
area of the19
sites in the19
also observed in19
were included in19
terminal domain of19
influence of the19
that activation of19
in the protein19
with and without19
the activities of19
in the er19
in black flying19
seems to be19
j o u19
significant changes in19
have investigated the19
r n a19
was significantly higher19
the synthetic viruses19
respiratory epithelial cells19
due to their19
is related to19
a subset of19
have been developed19
mouse model of19
u os cells19
for the study19
in the lateral19
epithelial cells and19
could be detected19
oligodendrocyte precursor cells19
within the first18
at the level18
a change in18
associated with an18
respect to the18
not only in18
in the future18
were associated with18
which may be18
mean age of18
h after the18
the context of18
but also in18
the interactions between18
derived neurotrophic factor18
a part of18
of chadox mers18
basis for the18
was blocked by18
did not significantly18
together with the18
similar to those18
cftr in the18
present study we18
binds to the18
investigate the effect18
school of life18
of these two18
localization of the18
in the past18
are shown in18
and characterization of18
significant differences in18
at the plasma18
we report here18
of the orf18
the initiation of18
the time course18
of the c18
bovine serum albumin18
the establishment of18
participate in the18
the nature of18
evidence suggests that18
microglia and astrocytes18
be explained by18
results of the18
to develop a18
different time points18
we are now18
the site of18
in the anterior18
information about the18
mechanisms underlying the18
the current study18
important for the18
the cftr gene18
was measured using18
reduction in the18
was no difference18
location of the18
inserted into the18
used to assess18
relationship between the18
studies showed that18
experiments showed that18
test this hypothesis18
localized in the18
the objective of18
crystal structure of18
antiviral activity of18
are present in18
which has been18
the proliferation of18
balb c mice18
regardless of the18
cells from the18
in accordance with18
need to be18
fetal bovine serum18
in these cells18
we have reported18
interact with the18
of the peptide18
to the dorsal18
that it is18
reported that the18
and suggest that18
were stained with18
cells and the18
of these proteins18
interaction of the18
of the r18
the viral genome18
were seen in18
decreased in the18
is the major18
b and c18
cellular and molecular18
of microglia and18
stability of the18
human immunodeficiency virus17
affected by the17
localized to the17
agreement with the17
more than of17
patients in the17
is observed in17
of spinal cord17
treatment of cf17
that had been17
both in vitro17
previously demonstrated that17
disruption of the17
a role of17
of the dentate17
as compared with17
as a consequence17
of this work17
and secretion of17
evidence that the17
presence or absence17
were added to17
time of the17
spinal cord and17
likely to be17
molecular mechanisms underlying17
the type of17
cf patients who17
essential for the17
the host cell17
with pseudomonas aeruginosa17
of vitamin d17
have been proposed17
mechanisms by which17
is a major17
of viral rna17
in the cerebral17
determined by the17
these results indicated17
was designed to17
lung function in17
to infection by17
loss of the17
at different time17
for physiological sciences17
functional significance of17
epidemic diarrhea virus17
at the c17
cells in a17
carried out in17
been implicated in17
is possible that17
infection of the17
in the n17
faculty of medicine17
serves as a17
the severity of17
reduction of the17
mechanism for the17
from the same17
that did not17
of pulmonary exacerbations17
in spite of17
portion of the17
of rna viruses17
the pattern of17
transiently transfected with17
synaptic transmission in17
for use in17
from cf patients17
a small number17
could be a17
patients who were17
inhibitory effect of17
that the expression17
but did not17
studies on the17
for cystic fibrosis17
at the beginning17
were subjected to17
was a significant17
impact on the17
involvement of the17
wild type and17
of science and17
studies indicate that17
to generate a17
is required to17
been associated with17
resonance energy transfer17
min at room17
investigation of the17
excitatory and inhibitory17
was induced in17
the response to17
for more than17
injected into the17
performed in the17
not observed in17
in the hypothalamus17
because of the17
for in vivo17
were identified as17
metropolitan institute for17
difference between the17
the type i17
in human cells17
interfere with the17
in the context17
was evaluated by17
referred to as17
expression levels were17
significantly higher in17
institute for neuroscience17
p y receptor17
or absence of17
is known that16
cat k m16
ca pyramidal neurons16
these findings indicate16
at uc for16
of anatomy and16
k cat k16
the hippocampal ca16
are not well16
at our center16
the expression levels16
levels of the16
of the sars16
of the mouse16
positive cells were16
a model system16
the cleavage site16
oxidative stress and16
the main calyx16
this is a16
lower than that16
data from the16
because of its16
of lipid droplets16
is believed to16
it is unclear16
the expression level16
an moi of16
well as to16
caused by the16
cf patients in16
institute of biophysics16
was increased by16
the specificity of16
equine encephalitis virus16
recently reported that16
at the n16
japan science and16
significantly reduced the16
shows that the16
the maturation of16
was not affected16
signals in the16
viruses such as16
in the ob16
the nucleolus after16
japan we examined16
to the formation16
objective of this16
and incubated for16
independent of the16
was performed on16
caused by a16
we have now16
the behavior of16
advantage of the16
were collected at16
allows us to16
be expressed in16
of a new16
of cell surface16
with the same16
during the study16
which is the16
were unable to16
determination of the16
venezuelan equine encephalitis16
but it is16
is sufficient to16
the antiviral activity16
rna binding motifs16
peripheral nervous system16
as early as16
of lung disease16
during the course16
responses to the16
goal of this16
is poorly understood16
the visual cortex16
it is likely16
of these patients16
the growth cone16
as a marker16
proteins involved in16
oligodendrocyte progenitor cells16
also show that16
activated protein kinase16
fluorescence correlation spectroscopy16
in this case16
a powerful tool16
is a highly16
structure and function16
the cf lung16
results demonstrated that16
were performed on16
mutation in the16
the genome of16
used in this16
infected cells were16
the migration of16
consistent with a16
be found in16
the translocation of16
of the respiratory16
incubated with the16
is not known16
the order of16
mice treated with16
with a mean16
investigate the role16
the sox cut16
in the ventral16
transfected with the16
factors such as16
have previously reported16
the s protein16
and the effect16
patients and families16
are used to16
significantly increased the16
used to measure16
and end of16
by using the16
needs to be16
the position of16
of cells expressing16
appeared to be16
a consequence of16
we concluded that16
expression level of16
supported by grants16
gene expression of16
levels were measured16
were identified in16
a loss of16
and spinal cord16
the morphology of16
diseases such as16
as one of16
plasma membrane of16
decline in lung16
innate immune responses16
and can be16
with changes in16
were maintained in16
have studied the16
be responsible for16
it is known16
with regard to16
a marker for16
that there are16
in the current16
in both the16
compared with those16
studies of the16
in the table15
of this protein15
bl j mice15
no change in15
molecular basis of15
model of the15
the incidence of15
semliki forest virus15
is an essential15
of expression of15
and cells were15
and compared to15
when compared with15
we investigate the15
this is the15
to be more15
number of cells15
of the mature15
nucleolus after hs15
in the peripheral15
is increased in15
in rat hippocampal15
for h in15
study suggests that15
are required for15
and did not15
the population of15
accordance with the15
the presence and15
more likely to15
piglets in the15
and treated with15
rate of decline15
kyushu institute of15
of pharmaceutical sciences15
cystic fibrosis is15
strand rna viruses15
important role of15
have been found15
these cells were15
is likely to15
an essential role15
lead to a15
the hippocampus and15
the identity of15
the introduction of15
and mortality in15
is not well15
production of il15
expression was observed15
higher in the15
in the range15
a population of15
primary motor cortex15
the survival of15
indicates that the15
these results provide15
the secretion of15
but not by15
of pseudomonas aeruginosa15
the results show15
enriched in the15
broad spectrum of15
of our study15
gfp fusion protein15
middle cerebral artery15
been proposed to15
of children with15
inflammatory response in15
magnetic resonance imaging15
school of medical15
site of the15
to wild type15
of up to15
the cells with15
be important for15
the corpus callosum15
input from the15
assumed to be15
neurons and astrocytes15
to provide a15
individuals with cf15
the brain and15
in vitro transcription15
kinetics of the15
this process is15
significant reduction in15
of the green15
a panel of15
suggest that a15
will discuss the15
functional role of15
the presence or15
cf patients were15
linked to the15
vitamin d deficiency15
is likely that15
are poorly understood15
implicated in the15
areas of the15
a useful tool15
was accompanied by15
that have been15
early stages of15
the effectiveness of15
and incubated with15
nature of the15
on the membrane15
patients were included15
in the dentate15
of neurons and15
were seeded in15
school of science15
incubated for h15
is expected to15
days in vitro15
human and mouse15
was seen in15
we carried out15
of the f15
an animal model15
have to be15
did not have15
department of neurology15
of cell biology15
cultured cortical neurons15
in gene expression15
cells that were15
the correlation between15
a pulmonary exacerbation15
of both the15
a reduction of15
those in the15
the results obtained15
in all the15
length of the15
change in fev15
result in a15
in pc cells15
these data indicate15
of the channel15
a recent study15
morris water maze15
well known that15
mechanisms of the15
using the same15
resulting in a15
of severe acute15
quantitative analysis of15
fused to the15
followed by the15
in airway epithelial15
of the left15
a central role15
in t cells15
in both cell15
is still unclear15
cells with the15
supplemented with fetal15
have also been15
also in the15
terminal processing site15
were stimulated with15
has been previously15
for treatment of15
were determined by15
positive cells in15
to contribute to15
specificity of the15
in the process15
protein expression in15
cells with a15
identified as a15
can also be15
total rna was15
the beginning of15
the most frequent15
in glial cells15
of gene expression15
their role in15
involved in this15
expression pattern of15
significant increase of15
the mature form15
magnitude of the15
in the airways15
each of these15
interactions between the14
in live cells14
in human and14
to be expressed14
it is a14
physiological role of14
transmission in the14
we have generated14
mice in which14
has recently been14
the quality of14
in cfbe o14
was present in14
patients who had14
reporter gene expression14
the uptake of14
features of the14
in vivo studies14
the degradation of14
lower in the14
has been known14
adolescents with cf14
activity and the14
as a novel14
the goal of14
and expression of14
and differentiation of14
dorsal root ganglion14
the brains of14
significantly increased in14
higher levels of14
in the last14
of cl pro14
the insertion of14
a mutation in14
school of pharmaceutical14
with chadox gfp14
the reduction of14
not in the14
functions of the14
in transgenic mice14
account for the14
of the total14
a measure of14
department of neurophysiology14
hypothesized that the14
the fraction of14
to the presence14
in cf sputum14
be one of14
and in vitro14
the determination of14
of the sox14
parts of the14
pyramidal neurons in14
have examined the14
pediatric and adult14
by increasing the14
of the other14
was observed between14
the airway epithelial14
the relevance of14
was defined as14
mechanical properties of14
activation of microglia14
away from the14
italian institute of14
a final concentration14
in a dose14
surface expression of14
and examined the14
sites of the14
in the tgev14
the auditory cortex14
identification of the14
channels in the14
of changes in14
presented in the14
with an increase14
different brain regions14
has been developed14
in the non14
considered as a14
in the culture14
of the cleavage14
detection of the14
amino acid residues14
and the number14
the two groups14
the removal of14
open reading frame14
in cf airways14
a period of14
with those of14
days of age14
which leads to14
the direction of14
to an increase14
by the cf14
suggest that these14
maintenance of the14
of the proteins14
decline in fev14
laser scanning microscopy14
different from that14
of the adult14
were generated by14
there is an14
processes in the14
we found the14
were no significant14
the structure and14
to form a14
has been described14
in epithelial cells14
well as a14
of chikv ls14
interactions with the14
with pbs and14
ca region of14
in wt mice14
of inflammatory monocytes14
with cf were14
the idea that14
studies were performed14
rat hippocampal slices14
of the four14
consistent with previous14
a significant reduction14
we propose a14
at the surface14
importance of the14
for cf patients14
characteristics of the14
our data show14
in vivo imaging14
play a key14
to be associated14
the primary visual14
this result suggests14
to detect the14
reduced in the14
male and female14
from the lungs14
here we investigated14
in recent years14
is essential to14
we aim to14
for patients with14
as in the14
of life science14
the expression and14
under physiological conditions14
influenced by the14
results suggest the14
as an important14
kenyon cells receive14
m and m14
as a positive14
and molecular mechanisms14
is accompanied by14
absence of the14
was detected with14
primary visual cortex14
dependence of the14
manipulation of the14
min at uc14
left and right14
activities of the14
study aimed to14
of influenza a14
soluble form of14
was identified as14
brain research institute14
not involved in14
of the cd14
as shown by14
to the nucleolus14
any of the14
in a cell14
the sensitivity of14
final concentration of14
cells were also14
the mechanism by14
was monitored by14
results in the14
in this population14
is a useful14
was significantly increased14
which have been14
the recovery of14
was bound to14
mice compared to14
to reduce the14
been reported that14
fraction of the14
and western blot14
in the apical14
b and d14
of the gene14
of the dorsal14
of these neurons14
between these two14
in figure a14
the adult brain14
functions as a14
activities in the14
were grown in14
aqueous extract of14
the first step14
was not observed14
we report a13
can be a13
is similar to13
h at uc13
three independent experiments13
in conjunction with13
cell adhesion molecules13
both in the13
in vitro studies13
it is still13
the mechanisms underlying13
to investigate how13
it may be13
of the tgev13
as indicated by13
been linked to13
caused by mutations13
was analyzed by13
have suggested that13
by western blotting13
induced by a13
of age and13
department of cell13
for minutes at13
when exposed to13
subjects with cf13
was significantly reduced13
compared to that13
leading to a13
in the mutant13
the synthesis of13
of the cut13
and technology agency13
is necessary to13
to the c13
the inner ear13
of the different13
were transiently transfected13
our cf center13
in our laboratory13
step in the13
were classified as13
the fate of13
with that of13
was related to13
be a useful13
are required to13
a previous study13
for the detection13
activated cell sorting13
not significantly different13
funded by the13
at the start13
medial prefrontal cortex13
one of these13
we attempted to13
proteins such as13
in expression of13
the ventral accessory13
of biophysics and13
the cf team13
in well plates13
expression patterns of13
the functional role13
were collected and13
of the mutant13
different from the13
has shown that13
amyotrophic lateral sclerosis13
the amino acid13
at an moi13
the processing of13
many of the13
western blot and13
the authors declare13
to address the13
may be due13
was identified in13
structures of the13
which could be13
egfp reporter gene13
of the reporter13
those of the13
changes of the13
to visualize the13
give rise to13
to define the13
than that in13
the volume of13
a decrease of13
virus infection in13
cell patch clamp13
order to determine13
there have been13
of a small13
and changes in13
not fully understood13
was removed and13
of p x13
and s b13
supernatants were collected13
of such a13
our findings suggest13
rna was extracted13
membrane expression of13
in this model13
onset of the13
c and d13
role of these13
to establish the13
japan we investigated13
we identified a13
central role in13
recovery of the13
by grants from13
was injected into13
significant difference between13
of the mammalian13
in the pathophysiology13
recovery after photobleaching13
in pulmonary function13
of the interaction13
its role in13
ventral accessory calyx13
the most important13
especially in the13
used to monitor13
damage in the13
not yet been13
of viral replication13
by addition of13
myelin basic protein13
is the main13
of the ca13
washed three times13
using the r13
the length of13
to examine whether13
concentration of the13
in a wide13
are likely to13
resulted in the13
by rna interference13
the airway epithelium13
has to be13
cf bronchial epithelial13
aspects of the13
are the most13
the present results13
representation of the13
different cell types13
the optic lobe13
of the genome13
was performed with13
due to an13
that inhibition of13
depend on the13
a major role13
was similar to13
coding region of13
transmission electron microscopy13
of microglial cells13
studies suggest that13
cell lines were13
of neutralizing antibodies13
fos expression in13
tokyo university of13
the phosphorylation of13
the p y13
the components of13
did not observe13
to further investigate13
formed by the13
domain of the13
gene in the13
in a large13
hippocampal ca region13
as evidenced by13
were incubated for13
to obtain a13
and some of13
our data indicate13
layer of the13
virus replication in13
here we present13
in cf is13
been used for13
consistent with this13
cerebral cortex and13
specifically in the13
that most of13
is needed to13
alterations in the13
removal of the13
in the basal13
of patients were13
the same as13
to the surface13
of the non13
isolated from the13
been suggested that13
resulted in an13
of hepatitis b13
and has been13
the immune response13
whether or not13
pcr products were13
by the cystic13
the cf patients13
could contribute to13
may be useful13
we found no13
the subventricular zone13
stages of the13
the left and13
to monitor the13
with fetal bovine13
the na k13
increased risk of13
some of them13
infants with cf13
comparison of the13
of the signal13
a mixture of13
higher than the13
by mass spectrometry13
were compared with13
and distribution of13
on the same13
the molecular level13
apical surface of13
test the hypothesis13
provide evidence that13
the emergence of12
in wild type12
provided by the12
is a powerful12
in the other12
of the complex12
cd and cd12
plays a key12
cells were observed12
studies have demonstrated12
which in turn12
we also examined12
expression of p12
structure and dynamics12
the results indicate12
p y receptors12
recorded from the12
caused a significant12
was quantified by12
to a significant12
associated with increased12
was significantly lower12
lung disease in12
and loss of12
adult patients with12
superior lateral protocerebrum12
may not be12
of pcg proteins12
in cells infected12
for studying the12
these data show12
characterization of a12
consists of a12
consists of two12
might contribute to12
upstream of the12
is a novel12
was to evaluate12
study we have12
trafficking to the12
time in the12
into the brain12
were performed to12
were measured in12
a cells were12
aid for scientific12
mg kg day12
is composed of12
have previously demonstrated12
the evolution of12
the deletion of12
of the binding12
nuclear translocation of12
induction of the12
of the chromophore12
showed a significant12
plasma membrane expression12
animal model of12
was obtained from12
a positive control12
based on our12
of at least12
the fusion of12
of the second12
institutes of health12
lung function and12
the mechanism underlying12
inhibitory effects of12
bv and mlt12
was detected by12
and glial cells12
cleavage sites in12
the stimulation of12
of the peripheral12
the gene encoding12
this study aimed12
the mean fev12
pyramidal cells in12
lc and lamp12
was abolished by12
males and females12
times with pbs12
the assembly of12
under the same12
of neuronal activity12
pattern of the12
a family of12
a model for12
may have a12
p and ndp12
in more detail12
t rna polymerase12
of lung function12
transgenic chicken embryos12
a new method12
some of these12
that could be12
it would be12
rat spinal cord12
glial cells and12
of wild type12
that they have12
the expression pattern12
of the sample12
been suggested to12
excitation and emission12
to the central12
yellow fluorescent protein12
is affected by12
the f del12
understand the role12
with a significant12
free protein synthesis12
patients compared to12
and the expression12
proportional to the12
that expression of12
a potential therapeutic12
we constructed a12
the active site12
in a significant12
of the infection12
changes induced by12
mainly due to12
the actin cytoskeleton12
to the a12
the autophagy pathway12
gfp expression was12
at least three12
in the cftr12
protein quality control12
and dynamics of12
the crystal structure12
site in the12
and protein expression12
to control the12
of virus replication12
is widely used12
were processed for12
programmed cell death12
a hallmark of12
after h of12
the fluorescence intensity12
hek t and12
roles of the12
both cell types12
in ng cells12
of the glial12
in our cf12
of the receptor12
by activation of12
the most effective12
the superior lateral12
the construction of12
using a combination12
care and use12
the utility of12
has previously been12
zone of the12
binding of the12
from that of12
of decline in12
for scientific research12
the transcription factor12
they do not12
be required for12
in this region12
restricted to the12
bronchial epithelial cell12
phosphorylation of the12
used to identify12
vitamin d levels12
information from the12
of the visual12
in clinical trials12
the respiratory tract12
in the cytoplasm12
in vero cells12
was cloned into12
tenuissima nakai extracts12
would like to12
cerebral artery occlusion12
the in vitro12
in astrocytes in12
we have established12
in a mouse12
in subjects with12
attributed to the12
the elp tag12
were detected by12
lung epithelial cells12
predicted to be12
with the use12
induced cell death12
that the protein12
were purchased from12
were isolated from12
an in vivo12
the mode of12
not appear to12
genes in the12
in the medial12
s and s12
of the genes12
processing in the12
in this paper12
were inoculated with12
a and a12
but also the12
the nmda receptor12
in case of12
was assessed in12
cultured hippocampal neurons12
of the molecular12
interacts with the12
the vicinity of12
and inhibition of12
has been identified12
of a large12
cf patients are12
nippon medical school12
cell biology and12
least in part12
who did not12
role for the12
comparison with the12
different concentrations of12
was determined using12
it is also12
from those of12
from the cell12
use of a12
the other two12
of the fluorescence12
plays a crucial12
in both groups12
events in the12
mouse models of12
medium supplemented with12
deletion of the12
our preliminary results12
not been well12
the growth of12
low levels of12
is present in12
has been observed12
transfection efficiency of12
result of the12
accumulate in the12
reported in the12
could be involved12
the phenotype of12
weeks of age12
may be important12
different from those12
the start of12
through the activation12
were incubated at12
adjacent to the12
ability of the12
the lipid bilayer12
was measured in12
was reported to12
essential role in12
model for the12
we use a12
in activated microglia12
and to the11
was to examine11
several types of11
the r h11
of synaptic plasticity11
u and u11
and an increase11
differentiated respiratory epithelial11
the cf center11
is not a11
months of age11
results suggest a11
epithelial cells were11
to play an11
to follow the11
cut site in11
in animal models11
cortex and hippocampus11
work was to11
university of tsukuba11
were fixed and11
for h and11
present on the11
could lead to11
we do not11
could be found11
in the supernatant11
targeted rna recombination11
goal is to11
was significantly decreased11
of cells with11
bronchoalveolar lavage fluid11
presence of two11
frequency of the11
to be important11
lapse imaging of11