quadgram

This is a table of type quadgram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

quadgram	frequency
severe acute respiratory syndrome	73
angiotensin ii type receptor	64
acute respiratory distress syndrome	46
has been shown to	38
vascular smooth muscle cells	36
acute respiratory syndrome coronavirus	36
in patients with covid	28
of angiotensin converting enzyme	28
with the use of	27
in addition to the	24
of severe acute respiratory	24
components of the ras	23
to the plasma membrane	23
the angiotensin ii type	23
the use of aceis	23
angiotensin ii receptor blockers	22
converting enzyme inhibitors and	22
use of aceis arbs	22
on the other hand	21
an important role in	21
and angiotensin ii receptor	20
the renin angiotensin system	19
have been shown to	19
in the pathogenesis of	19
in the development of	19
enzyme inhibitors and angiotensin	19
use of an acei	18
systematic review and meta	17
in the treatment of	17
of the ras in	17
the central nervous system	17
of an acei arb	16
patients with coronavirus disease	16
vascular endothelial growth factor	15
inhibitors and angiotensin receptor	15
of the renin angiotensin	15
studies that provided adjusted	15
in the regulation of	14
and angiotensin receptor blockers	14
role of the renin	14
angiotensin i to angiotensin	14
for the treatment of	14
epidermal growth factor receptor	14
the use of ras	14
in vascular smooth muscle	14
of the angiotensin ii	14
in spontaneously hypertensive rats	14
use of ras inhibitors	14
of developing severe critical	14
vitro and in vivo	13
in vitro and in	13
in the central nervous	13
effects of ang ii	13
angiotensin ii receptor antagonist	13
in the context of	13
in the absence of	13
of aceis arbs in	13
plays an important role	13
of the ras and	12
in a mouse model	12
ace ang ii at	12
a crucial role of	12
of the brain ras	12
inhibitors and angiotensin ii	12
role of angiotensin converting	12
the dm ab group	12
the risk of mortality	12
in a rat model	12
of ang ii in	12
the use of an	12
of patients infected with	12
studies have shown that	12
has been reported to	11
of patients with covid	11
of the ace gene	11
crucial role of angiotensin	11
r and at r	11
a mouse model of	11
i and ang ii	11
in patients with sars	11
role of ace in	11
between the use of	11
the ras in the	11
it has been reported	11
an angiotensin ii receptor	10
as well as the	10
as a result of	10
to the development of	10
the angiotensin converting enzyme	10
and the risk of	10
middle east respiratory syndrome	10
association between the use	10
a retrospective cohort study	10
the role of the	10
been shown to be	10
ace inhibitors and arbs	10
of angiotensin ii receptor	10
ang i and ang	10
of the mas receptor	10
ii receptor blockers on	10
angiotensin converting enzyme inhibitors	10
at r and at	10
of the ang ii	10
functional receptor for sars	10
in acute respiratory distress	10
a systematic review and	10
in the presence of	10
arm of the ras	9
the severe acute respiratory	9
risk of developing severe	9
converts angiotensin i to	9
in the heart and	9
regulator of the renin	9
the risk of severe	9
expression of at r	9
patients infected with sars	9
the loss of ace	9
at and at receptors	9
an essential regulator of	9
of the ace ang	9
aceis arbs in covid	9
of the at r	9
the activation of the	9
the spike protein of	9
and risk factors for	9
a key role in	9
the role of ace	9
in acute lung injury	9
of the ras pathway	9
regulator of heart function	9
of the at receptor	9
of the classical ras	9
essential regulator of heart	9
functional expression as a	8
respiratory syndrome coronavirus infection	8
of ang ii and	8
mortality of adult inpatients	8
targeted to the plasma	8
ang ii in the	8
activation of at r	8
angiotensin system in the	8
with novel coronavirus in	8
of angiotensin ii type	8
patients with novel coronavirus	8
in individuals with diabetes	8
adult inpatients with covid	8
has been reported that	8
converting enzyme in the	8
normal lung tissue and	8
cloning and functional expression	8
of adult inpatients with	8
and functional expression as	8
in the cardiovascular system	8
a crucial role in	8
time to the virus	8
of vascular smooth muscle	8
outcomes in patients with	8
exposure time to the	8
is an essential regulator	8
in the risk of	8
in the pathophysiology of	8
for mortality of adult	8
of ace in the	8
compared to the non	8
in a variety of	8
in normal lung tissue	8
spike protein of sars	8
risk factors for mortality	8
a human homolog of	8
course and risk factors	8
a rat model of	8
clinical course and risk	8
of severe critical outcomes	8
compared with the control	8
ii type receptor blockade	8
infected with novel coronavirus	8
factors for mortality of	8
it is reasonable to	8
induced by angiotensin ii	8
of angiotensin ii receptors	8
developing severe critical illness	8
a central role in	8
it is important to	8
a l p r	7
the expression of the	7
the protein expression of	7
a negative regulator of	7
has been found that	7
a critical role in	7
ang i to ang	7
receptor blockers on cardiac	7
it has been suggested	7
it has been found	7
of transforming growth factor	7
the effects of ang	7
j o u r	7
in patients with diabetes	7
axis of the ras	7
risk of severe critical	7
nih t cells were	7
l p r e	7
of ang ii to	7
of the ras system	7
with diabetes infected with	7
patients infected with novel	7
activation of the ras	7
in patients with chronic	7
been shown to have	7
in the dm ab	7
converting enzyme is a	7
r n a l	7
blockers on cardiac angiotensin	7
attenuates the progression of	7
p r o o	7
clinical characteristics of coronavirus	7
inhibitors in patients with	7
u r n a	7
in chronic kidney disease	7
r o o f	7
of coronavirus disease in	7
the association between the	7
it is possible that	7
o u r n	7
enzyme is an essential	7
no conflict of interest	7
in the lung tumor	7
enzyme inhibition and angiotensin	7
in hospitalized patients with	7
and oxidative stress in	7
n a l p	7
features of patients infected	7
actions of ang ii	7
by angiotensin ii in	7
the conversion of ang	7
receptor for sars coronavirus	7
converting enzyme protects from	7
reported a higher crude	7
with severe acute respiratory	7
coronavirus disease in china	7
patients with type diabetes	7
regulator of the ras	7
at the same time	7
angiotensin converting enzyme inhibitor	7
of the plasma membrane	7
characteristics of coronavirus disease	7
system inhibitors in patients	7
expression as a captopril	7
angiotensin ii receptor subtypes	7
that provided adjusted estimates	7
that ang ii could	7
has been suggested that	7
plays a role in	7
the formation of ang	7
the lung tumor tissue	7
were found to be	7
with lower odds of	7
renin angiotensin system in	7
in patients with coronavirus	7
of ace inhibitors and	7
patients hospitalized with covid	7
clinical features of patients	7
inhibitors of the renin	7
ace inhibitors and at	7
prevention and treatment of	7
for severe critical outcomes	7
inhibition and angiotensin ii	7
of ang i and	7
of podocyte injury in	7
converting enzyme is an	6
from severe acute lung	6
the effects of the	6
infected patients linked to	6
ectodomain shedding of the	6
the mrna expressions of	6
severe acute lung failure	6
shedding of the severe	6
vascular smooth muscle cell	6
ncov infected patients linked	6
of aceis arbs and	6
viral loads and lung	6
under the control of	6
angiotensin receptor blockers on	6
significant association with lower	6
binding domain complexed with	6
a wide variety of	6
in experimental models of	6
derivatives of ras l	6
in the gastrointestinal tract	6
the risk of covid	6
membrane versions of ras	6
of the ras are	6
integral membrane versions of	6
human bronchial epithelial cells	6
in cardiovascular and renal	6
correction for multiple comparisons	6
plays a crucial role	6
mediates regulated ectodomain shedding	6
in patients with type	6
involvement of the ras	6
a first step in	6
death in patients with	6
treatment with ace inhibitors	6
a high level of	6
converting enzyme inhibition and	6
the rostral ventrolateral medulla	6
illness with the use	6
ace expression in rat	6
the structure of the	6
as an integral membrane	6
angiotensin ii receptor blocker	6
the ace ang ii	6
into intensive care units	6
tissue distribution of ace	6
to the risk of	6
molecular mechanisms and potential	6
developing severe critical disease	6
has been identified as	6
effect of angiotensin ii	6
and angiotensin converting enzyme	6
inhibitors angiotensin receptor blockers	6
mechanisms and potential therapeutic	6
a functional receptor for	6
may be associated with	6
by blockade of angiotensin	6
components of the renin	6
play an important role	6
angiotensin ii production and	6
human homolog of angiotensin	6
in subjects with diabetes	6
connective tissue growth factor	6
the angiotensin type receptor	6
and vascular smooth muscle	6
as a consequence of	6
first step in understanding	6
ace inhibitors or arbs	6
converting enzyme in human	6
hospitalized patients with covid	6
system blockers and the	6
and potential therapeutic target	6
step in understanding sars	6
sodium and water absorption	6
loads and lung injury	6
be involved in the	6
difference in the risk	6
the components of the	6
podocytes cultured in vitro	6
in patients with advanced	6
in the ace gene	6
in understanding sars pathogenesis	6
in lung tumor tissue	6
ang ii and ang	6
and biochemical indexes from	6
to severe acute respiratory	6
conversion of ang i	6
an integral membrane protein	6
in the dm group	6
the glomerular basement membrane	6
provided adjusted mortality estimates	6
ii type receptor in	6
is involved in the	6
outcomes of patients with	6
patients linked to viral	6
linked to viral loads	6
aldosterone system inhibitors in	6
protects from severe acute	6
enzyme inhibitors angiotensin receptor	6
east respiratory syndrome coronavirus	6
induced acute lung injury	6
converting enzyme inhibitors angiotensin	6
receptor for the sars	6
for the prevention of	6
is highly expressed in	6
play a role in	6
enzyme protects from severe	6
in addition to its	6
it was found that	6
effects of ras inhibitors	6
of the components of	6
of ang ii by	6
the functional receptor for	6
expression of ace in	6
the protective arm of	6
the mrna expression of	6
clinical and biochemical indexes	6
ace inhibitors and angiotensin	6
to viral loads and	6
the effects of ace	6
distribution of ace protein	6
protective arm of ras	6
in the brain and	6
no conflicts of interest	6
and its role in	6
ii in the brain	6
regulated ectodomain shedding of	6
advanced glycation end products	5
hypertension and diabetes mellitus	5
have been identified in	5
the discovery of ace	5
to an increase in	5
that reported a higher	5
such as hypertension and	5
mediated by at receptors	5
of vascular endothelial growth	5
in patients with hypertension	5
and the development of	5
receptor in angiotensin ii	5
compared to those with	5
use of these drugs	5
with the control group	5
plays a key role	5
manipulation of the ras	5
on the role of	5
of the ras has	5
at receptors in the	5
i to ang ii	5
in angiotensin ii production	5
structural basis for the	5
a large number of	5
ras in the lung	5
was shown to be	5
lung tissue and lung	5
and cellular responses to	5
ligand for the g	5
in vascular endothelial cells	5
the at r and	5
association of cardiac injury	5
of at r in	5
of hxt and hxt	5
more likely to die	5
central role in the	5
the regulation of the	5
and risk of cancer	5
cardiac injury with mortality	5
has also been shown	5
nonproteolytic activation of prorenin	5
an essential role in	5
the sympathetic nervous system	5
acei arb users and	5
endothelial nitric oxide synthase	5
for the sars coronavirus	5
in the united states	5
production and cellular responses	5
tissue and lung tumor	5
acei arb users with	5
corrected for multiple comparisons	5
that provided adjusted mortality	5
among patients with covid	5
acting on the ras	5
converting enzyme and angiotensin	5
rate for severe critical	5
to the activation of	5
inhibitors and risk of	5
an acei arb was	5
in the rostral ventrolateral	5
structure and function of	5
with type diabetes and	5
the heart and kidneys	5
role in maintaining the	5
the authors declare no	5
on the surface of	5
ii production and cellular	5
small cell lung cancer	5
an animal model of	5
innate and adaptive immune	5
in the three groups	5
novel coronavirus in wuhan	5
basis for the recognition	5
with mortality in hospitalized	5
mortality in hospitalized patients	5
should not be used	5
the plasma membrane by	5
in the case of	5
of components of the	5
the progression of diabetic	5
human vascular smooth muscle	5
patients with hypertension hospitalized	5
use of arbs and	5
of acute respiratory distress	5
of reactive oxygen species	5
it is clear that	5
cellular responses to renin	5
is an endogenous ligand	5
demonstrated no significant difference	5
formation of ang ii	5
vk and vk were	5
vascular senescence and sasp	5
of the protective arm	5
reactive oxygen species in	5
and vk were used	5
of captopril on bone	5
effect of captopril on	5
effects of the ace	5
ii type receptor and	5
vk were used to	5
for the recognition of	5
the use of arbs	5
of the ace angiotensin	5
effects on blood pressure	5
in health and disease	5
targeted derivatives of ras	5
angiotensin converting enzyme in	5
myocardial infarction by blockade	5
to the effects of	5
enzyme after myocardial infarction	5
in the general population	5
of the reninangiotensin system	5
of epidermal growth factor	5
of severe critical illness	5
high dose of captopril	5
our understanding of the	5
may play a role	5
the production of ang	5
has been proposed that	5
the development and progression	5
has not yet been	5
of cardiac injury with	5
of angiotensin ii and	5
development of glomerulosclerosis in	5
of novel coronavirus pneumonia	5
system blockade on renal	5
it is likely that	5
arb users and non	5
ras to the plasma	5
of patients with coronavirus	5
there is no evidence	5
compared with that of	5
endogenous ligand for the	5
is one of the	5
after myocardial infarction by	5
therapy in patients with	5
a lower risk of	5
levels of ang ii	5
association with lower odds	5
to the regulation of	5
sodium and water retention	5
role for ace in	5
prorenin receptor in angiotensin	5
as well as in	5
renin angiotensin system and	5
stimulation of at r	5
a role in the	5
c domain of sace	5
aldosterone system inhibitors and	5
was found to be	5
disease and ulcerative colitis	5
crude rate for severe	5
important role in the	5
functional receptor for the	5
the epidermal growth factor	5
in the progression of	5
blockade on renal angiotensin	5
of ang i to	5
crystal structure of the	5
the beneficial effects of	5
disease severity in covid	5
angiotensin ii at receptor	5
forming enzymes and receptors	5
ratio of opg rankl	5
angiotensin receptor blockers and	5
development and progression of	5
converting enzyme after myocardial	5
converting enzyme activity in	5
cardiovascular disease and hypertension	5
should be noted that	5
lower risk of mortality	5
the c domain of	5
transforming growth factor beta	5
of the novel coronavirus	5
oxidative stress in the	5
blockade of angiotensin ii	5
in an attempt to	5
and the expression of	5
injury with mortality in	5
an endogenous ligand for	5
in the early stage	5
one of the most	5
china clinical characteristics of	5
severe critical illness with	5
release of inflammatory cytokines	5
to be associated with	5
between acei arb users	5
effects of ace inhibitors	5
with acute respiratory distress	5
pivotal role of the	5
of ace expressing cells	5
hospitalized patients with novel	5
loss of ace in	5
ras in the gastrointestinal	5
angiotensin ii type a	5
of the ace axis	5
characteristics and outcomes of	5
it has been proposed	5
critical illness with the	5
the development of the	5
removal of senescent cells	5
those of ang ii	5
in which cells were	5
it should be noted	5
be due to the	5
by angiotensin ii type	5
in patients with severe	5
effects of angiotensin ii	5
for the g protein	5
infarction by blockade of	5
in the brain of	5
negative regulator of the	5
the recognition of sars	5
and transforming growth factor	5
significantly associated with lower	5
ang ii and at	5
blockade of the renin	5
the expression of ras	5
tmprss and is blocked	4
in the collecting duct	4
to the mas receptor	4
been shown to inhibit	4
inhibitors and at receptor	4
and outcomes of patients	4
angiotensin system in cardiovascular	4
were used to amplify	4
ii type receptor blocker	4
on the potential influence	4
ang ii is a	4
of fatal outcomes of	4
may be due to	4
with regards to the	4
to be involved in	4
increased the expression of	4
activated protein kinase kinase	4
the context of covid	4
novel coronavirus from wuhan	4
ang iv and ang	4
production of ang ii	4
between normal lung tissue	4
a pneumonia outbreak associated	4
its homologue ace and	4
and endothelial dysfunction in	4
that the use of	4
angiotensin converting enzyme gene	4
with preserved ejection fraction	4
inhibits development of glomerulosclerosis	4
be used as a	4
is important to note	4
of ace and ace	4
with that of the	4
blockers on onset and	4
out angiotensin ii in	4
and activation of the	4
of ang ii is	4
the glomerular filtration barrier	4
associated with lower odds	4
biological peptides by human	4
enzyme is a functional	4
angiotensin ii in the	4
renal sodium and water	4
bone of orx mice	4
ii type receptor antagonist	4
view of the ras	4
the heart and kidney	4
blockade inhibits development of	4
cells in the brain	4
to the cardiovascular system	4
syndrome leads to reduced	4
that compared with the	4
is blocked by a	4
the functional receptor of	4
likely to die of	4
inner surface of the	4
the ratio of opg	4
no significant difference with	4
the dm group was	4
increase the production of	4
in a model of	4
careful targeting of the	4
can be induced by	4
coronavirus of probable bat	4
viewpoint on the potential	4
the existence of an	4
the expression of tgf	4
of the active site	4
in the prefusion conformation	4
reduce the risk of	4
effect of ang ii	4
characteristics of hospitalized patients	4
clinical outcomes in covid	4
the ace and ace	4
of ras inhibitors on	4
loss of the protective	4
in patients hospitalized with	4
ace has been identified	4
may be involved in	4
was involved in the	4
ii in ards therapy	4
the ras has been	4
and blood pressure regulation	4
mortality with the use	4
mortality estimates for exclusively	4
trial of recombinant human	4
clinical characteristics of hospitalized	4
of recombinant human ace	4
to studies that provided	4
and is blocked by	4
modulator of the renin	4
ang ii at r	4
a high concentration of	4
by the action of	4
that the expression of	4
sars coronavirus spike receptor	4
kc hart and dj	4
of cases of novel	4
functional receptor of sars	4
gut microbiota in the	4
and at receptor blockers	4
the presence of a	4
angiotensin ii in ards	4
structure of the sars	4
a disintegrin and metalloproteinase	4
role of angiotensin ii	4
the protective role of	4
outbreak associated with a	4
disease in the elderly	4
on the cell membrane	4
reduced ratio of ace	4
associated with aging and	4
neprilysin in angiotensin peptide	4
a single amino acid	4
angiotensin ii in vascular	4
on ace and tmprss	4
effects of at r	4
induced by ang ii	4
ras have been identified	4
in a range of	4
a protective role of	4
of ras in the	4
of neutral amino acids	4
in diabetic kidney disease	4
diabetes infected with sars	4
integral membrane protein kc	4
after correction for multiple	4
is a functional receptor	4
to be able to	4
decrease in blood pressure	4
patients with acute respiratory	4
novel coronavirus pneumonia in	4
of ras in cardiovascular	4
respiratory distress syndrome leads	4
development of neurogenic hypertension	4
infected pneumonia in wuhan	4
limited to studies that	4
and at r in	4
conversion of angiotensin i	4
of gut microbiota in	4
a few small studies	4
new coronavirus of probable	4
has been made in	4
effects of captopril on	4
to reduced ratio of	4
and is prevented by	4
the course of the	4
more likely to have	4
increases ace expression in	4
in response to high	4
of critically ill patients	4
homologue ace and neprilysin	4
the epithelial cells of	4
it was demonstrated that	4
primers vk and vk	4
within and beyond the	4
the existence of the	4
or angiotensin receptor blockers	4
is a key modulator	4
the ace ace balance	4
critical illness from covid	4
it has been shown	4
ace deficiency accentuates vascular	4
clinical characteristics of patients	4
in patients infected with	4
loss of ace expressing	4
with ace inhibitors or	4
associated with the use	4
of the dm group	4
and facilitates viral entry	4
the progression of dn	4
axis of the renin	4
of aceis and arbs	4
of the interaction between	4
aortic smooth muscle cells	4
of the renin prorenin	4
onset and severity of	4
effect of ace inhibitors	4
ace and tmprss and	4
a key modulator of	4
no increased risk of	4
increase the risk of	4
to treat resistant hypertension	4
of blood pressure in	4
the renin prorenin receptor	4
the at r is	4
the spike proteins of	4
an analysis based on	4
sodium delivery to the	4
of death in patients	4
the pathogenesis of podocyte	4
leads to reduced ratio	4
amino acids in length	4
ii type receptor gene	4
for exclusively hypertensive patients	4
senescence in vascular smooth	4
the treatment of hypertension	4
use of angiotensin converting	4
surface of the plasma	4
progression of diabetic nephropathy	4
higher in patients with	4
in the spontaneously hypertensive	4
with a new coronavirus	4
of ace and the	4
cases of novel coronavirus	4
and lung tumor tissue	4
angiotensin system and the	4
of the spike protein	4
fission and er stress	4
implications of fatal outcomes	4
times more likely to	4
an increase in the	4
in the expression of	4
in blood pressure regulation	4
existence of the brain	4
patients with diabetes mellitus	4
converting enzyme and its	4
in accordance with the	4
version of this article	4
in diabetic angiotensin ii	4
the potential influence of	4
and the implications for	4
a significant decrease in	4
fibrosis and pulmonary hypertension	4
mortality in patients with	4
proteolytic cleavage of ace	4
the generation of ang	4
the crystal structure of	4
system in health and	4
severe acute respiratory distress	4
ang ii has been	4
with the plasma membrane	4
declare no conflict of	4
been identified as a	4
at increased risk for	4
this work was supported	4
mas axis of the	4
in db db mice	4
as the receptor for	4
neutral amino acid transporter	4
at r and masr	4
angiotensin system in human	4
receptor blockade inhibits development	4
acing out angiotensin ii	4
the angiotensin ii receptor	4
might be involved in	4
definitions of severe critical	4
a reduction in the	4
severe critical disease compared	4
structure of sars coronavirus	4
is prevented by angiotensin	4
both ace inhibitors and	4
of sars coronavirus spike	4
ras wt and ras	4
an increase in ace	4
of probable bat origin	4
in patients with cirrhosis	4
been identified in the	4
important to note that	4
potential influence of angiotensin	4
a higher crude mortality	4
regards to the risk	4
is a key mechanism	4
tumor necrosis factor alpha	4
experimental and clinical studies	4
level in normal lung	4
the nucleus tractus solitarius	4
single amino acid from	4
the ras system in	4
with regard to the	4
of mortality with the	4
pi k akt pathway	4
control of blood pressure	4
efficacy and safety of	4
in view of the	4
conversion of ang ii	4
relative to the non	4
the development of neurogenic	4
of expression of the	4
of recombinant human angiotensin	4
smooth muscle cells and	4
higher crude mortality rate	4
of the ace receptor	4
of gut microbiota and	4
cardiovascular implications of fatal	4
in the early s	4
ace activity in the	4
effects of these drugs	4
ace deficiency leads to	4
on the epithelial cells	4
estimates for severe critical	4
was identified as a	4
epithelial cells of oral	4
development of severe critical	4
play a central role	4
blood pressure response to	4
angiotensin system in health	4
promote the production of	4
of patients admitted to	4
the effect of aceis	4
it is not surprising	4
angiotensin i converting enzyme	4
dn and vlp groups	4
in the lungs of	4
a higher crude rate	4
protein kc hart and	4
the inner surface of	4
hydrolysis of biological peptides	4
of ang ii into	4
genes were found to	4
admission into intensive care	4
at r in the	4
higher crude rate for	4
entry into host cells	4
key modulator of the	4
ang ii type receptor	4
ace activities and is	4
response to ang ii	4
of the creative commons	4
and tmprss and is	4
the use of renin	4
and adaptive immune responses	4
of these drugs in	4
ii type a receptor	4
and in a sex	4
and severe critical outcomes	4
in support of this	4
mitochondrial fission and er	4
importance of ras in	4
difference with regards to	4
of biological peptides by	4
a new target for	4
as a therapeutic target	4
with hypertension and diabetes	4
lung fibrosis and pulmonary	4
it is hoped that	4
morbidity and mortality in	4
the activity of the	4
been shown to reduce	4
of the virus and	4
the exposure time to	4
role of autophagy in	4
diabetic angiotensin ii type	4
disease in china clinical	4
as a receptor for	4
and severity of severe	4
effects of the angiotensin	4
involved in the pathogenesis	4
and sudden cardiac death	4
might lead to increased	4
estimates for exclusively hypertensive	4
the glomerular filtration membrane	4
in an animal model	4
ace activity may be	4
of the glomerular basement	4
severe critical illness from	4
of ace expression in	4
the creative commons attribution	4
ii type receptor stimulation	4
to the severity of	4
glomerulosclerosis in diabetic angiotensin	4
both of which are	4
was based on the	4
the integrity of the	4
crucial role in the	4
of the ras with	4
domain complexed with receptor	4
distress syndrome leads to	4
ang ii into ang	4
protective arms of ras	4
expression of the ace	4
expression of the genes	4
activities and is prevented	4
that ace is the	4
or an angiotensin ii	4
blockers and the risk	4
been shown to induce	4
in the generation of	4
ang ii to form	4
ang ii to ang	4
angiotensin converting enzyme activity	4
to be one of	4
the at r in	4
ace inhibitors and arb	4
expression profiling of ace	4
the ras and the	4
prorenin receptor blockade inhibits	4
determine the presence of	4
risk of mortality with	4
global loss of ace	4
the pi k akt	4
the coding sequence of	4
on onset and severity	4
odds of developing severe	4
polymorphisms in the ace	4
feedback activation of circulating	4
to die of covid	4
receptor blockers on onset	4
of glomerulosclerosis in diabetic	4
on the risk of	4
fatal outcomes of patients	4
severity of severe acute	4
angiotensin ii and angiotensin	4
distributed under the terms	4
ace and neprilysin in	4
a clinically proven protease	4
pneumonia outbreak associated with	4
a new coronavirus of	4
by a clinically proven	4
of ace ace activities	4
ace ace activities and	4
critically ill patients with	4
for the use of	4
a novel target for	4
regulation of captopril on	4
of the intrarenal renin	4
may serve as a	4
gut microbiota might be	4
the unfolded protein response	4
the prevention and treatment	4
cell entry depends on	4
ii receptor blockers with	4
was expressed at a	4
individuals with diabetes with	4
the ability of the	4
a more severe course	4
membrane protein kc hart	4
to the presence of	4
angiotensin ii receptors and	4
epidemiological and clinical characteristics	4
structural studies of sars	4
wt and ras l	4
role in the pathogenesis	4
a novel angiotensinconverting enzyme	4
blood pressure in the	4
also been shown to	4
the receptor for sars	4
the group with severe	4
differences in immune responses	4
in response to ang	4
concentration of ang ii	4
adjusted mortality estimates for	4
in the group with	4
anchored as an integral	4
was associated with increased	4
the balance between the	4
the early stage of	4
renin prorenin receptor in	4
in a number of	4
expression of ace receptor	4
the protective effect of	4
of blood pressure and	4
similar to those of	4
hart and dj donoghue	4
in the formation of	4
associated with a new	4
em structure of the	4
depends on ace and	4
level of expression of	4
ratio of ace ace	4
the use of these	4
and coronary artery disease	4
entry depends on ace	4
cells of oral mucosa	4
the angiotensin ii at	4
the world health organization	4
ras anchored as an	4
of circulating or local	4
is mediated by angiotensin	4
to determine the presence	4
is associated with the	4
blocked by a clinically	4
in angiotensin peptide metabolism	4
and neprilysin in angiotensin	4
induced lung injury angiotensin	4
clinically proven protease inhibitor	4
and the pathogenesis of	4
of hospitalized patients with	4
is critical for the	4
during the course of	4
a viewpoint on the	4
blood pressure and renal	4
a direct or indirect	4
the existence of a	4
mortality among patients with	4
high concentration of glucose	3
distress syndrome during mechanical	3
the risk of developing	3
for blood pressure regulation	3
a protective role in	3
the regulation of glucose	3
incomplete renal fanconi syndrome	3
of the use of	3
cardiac hypertrophy and remodeling	3
by ace to produce	3
syndrome coronavirus and human	3
modulation of captopril on	3
of acute kidney injury	3
ace reduces the progression	3
unable to cause transformation	3
of a local renin	3
moderate level in normal	3
celebrating the th anniversary	3
of the effects of	3
there are a number	3
of angiotensin i and	3
differential downregulation of ace	3
of vasopressin from the	3
long term sequelae of	3
human renin and human	3
in cultured neonatal rat	3
r i p t	3
forming enzyme in brain	3
converting enzyme insertion deletion	3
factor in the development	3
cardiovascular and renal diseases	3
of at r by	3
molecular and cellular mechanisms	3
to be responsible for	3
and human coronavirus nl	3
of the effect of	3
of the transcription factor	3
and atherosclerosis in the	3
with hypertension hospitalized for	3
diabetic nephropathy by a	3
lower odds of developing	3
the role of ras	3
what is the evidence	3
and ulcerative colitis serum	3
the ace gene maps	3
of captopril on skeletal	3
and outcomes among patients	3
ace and ace in	3
found that ang ii	3
strains sky and sky	3
of the insulin receptor	3
viral entry to cells	3
patients who died of	3
at a r and	3
and aceis and arbs	3
aldosterone system blockers and	3
into sky and sky	3
of angiotensin i to	3
to a typical acute	3
downregulation of ace by	3
compared with the dm	3
ang ii generation by	3
to the generation of	3
more severe course of	3
have been demonstrated to	3
of renal injury in	3
arbs compared to the	3
angiotensin ii receptor type	3
likely play upstream roles	3
were included in the	3
chronic obstructive pulmonary disease	3
patients with hypokalaemia compared	3
in response to diet	3
the brain reninangiotensin system	3
contributes to the development	3
and therapeutic intervention protocols	3
critical disease compared to	3
at a moderate level	3
leading to the generation	3
is a member of	3
by ace inhibitors and	3
in patients with hypokalaemia	3
spontaneously hypertensive rats angiotensin	3
with respect to the	3
hypertensive patients with covid	3
a n u s	3
for treatment of covid	3
obvious feedback activation of	3
included hypertensive patients exclusively	3
and severe acute respiratory	3
derivatives of ras wt	3
via the at r	3
to further investigate the	3
atherosclerosis in the apoe	3
stimulation of the angiotensin	3
on the at receptor	3
effects of the ras	3
renin in the brain	3
analyses that were limited	3
arb users with covid	3
mice infused with angii	3
be withdrawn in patients	3
amino acids from the	3
of diabetes and ace	3
required for activation of	3
blockade of the ras	3
on the one hand	3
respiratory syndrome coronavirus spike	3
in the brain is	3
required for those with	3
and the sympathetic nervous	3
the expression of ace	3
respiratory distress syndrome during	3
in hypertensive patients with	3
in human heart failure	3
angiotensin converting enzyme inhibition	3
inhibition of diabetic nephropathy	3
on the epithelial side	3
of cardiac myocytes through	3
the gene which encodes	3
of each sample was	3
plasma renin activity and	3
nephropathy by a decoy	3
ii receptor blockers and	3
s c r i	3
by a decoy peptide	3
and upstream of the	3
ace in complex with	3
a moderate level in	3
in blood pressure control	3
cell proliferation and recruitment	3
myocardial infarction increases ace	3
to the b receptor	3
dm group compared with	3
and vessel exposure to	3
of ventricular fibrillation has	3
myocytes through activation of	3
disease compared to the	3
inhibitors or angiotensin receptor	3
highly correlated with the	3
infected with h n	3
of senescent cells by	3
and function of the	3
level and its expression	3
would like to thank	3
of severe critical disease	3
at r promotes the	3
receptor and regulator of	3
cardiothoracic robotic assisted surgery	3
lead to a typical	3
enhanced and protracted tissue	3
via at r and	3
and reproduction in any	3
analysis based on decade	3
have been reported in	3
it is hypothesized that	3
the beneficial effect of	3
the effect of ras	3
and regulator of the	3
which is available to	3
the expression ratio of	3
in the subfornical organ	3
of ace receptor of	3
the levels of renin	3
expression and activity in	3
deficiency accentuates vascular inflammation	3
those with myocardial dysfunction	3
of the local ras	3
dysbiosis of gut microbiota	3
increased morbidity and mortality	3
the at receptor and	3
i to angiotensin ii	3
map k and map	3
elderly and those with	3
with respect to early	3
the protective arms of	3
for a variety of	3
has been demonstrated in	3
characteristics of cases of	3
inflammatory cytokines such as	3
in myocardial infarcted rat	3
lamina propria mesenchymal cells	3
in the first place	3
ace is widely expressed	3
clearance of senescent cells	3
cov and ace induces	3
weight of the meta	3
the at receptor is	3
risk factor for cvd	3
in the kidney angiotensin	3
ii at receptor axis	3
in the elderly and	3
that the abundance of	3
is increasing evidence that	3
only a few studies	3
the role of autophagy	3
linked mental retardation and	3
implicated in the regulation	3
at the end of	3
the treatment of covid	3
of human bronchial epithelial	3
enzyme in heart failure	3
the presence of heterogeneity	3
of ras components in	3
for severe acute respiratory	3
ii and ang iii	3
of ace by the	3
studies have demonstrated that	3
has been demonstrated by	3
ace inhibitor and arb	3
expression in rat and	3
or risk of death	3
lipid accumulation in podocytes	3
effect of ras inhibitors	3
might be closely related	3
group with severe covid	3
ras in the pathophysiology	3
has been linked to	3
the chinese national health	3
the cyc tt region	3
represents a potential target	3
patients with cirrhosis and	3
ulcerative colitis serum angiotensin	3
spike glycoprotein of sars	3
coronavirus and human coronavirus	3
examining the effects of	3
as a novel therapeutic	3
to a reduction in	3
long structural studies of	3
n u s c	3
mas receptor axis in	3
be attributed to the	3
among patients hospitalized with	3
anniversary of the discovery	3
enzyme by the spike	3
in rat and humans	3
can be attenuated by	3
by angiotensin converting enzyme	3
characteristics of patients infected	3
the development of glomerulosclerosis	3
through the mas receptor	3
recombinant human angiotensinconverting enzyme	3
particularly with respect to	3
a direct effect on	3
targeting of the ras	3
the structure and function	3
of the two x	3
the severity of covid	3
information is available regarding	3
prevention of angiotensin ii	3
of hypertension in spontaneously	3
were limited to studies	3
ace to form a	3
patients with severe disease	3
been identified as the	3
ii has been shown	3
to the formation of	3
hypertension in spontaneously hypertensive	3
a systematic review of	3
the spike protein and	3
the interaction of the	3
have shown that the	3
axes of the ras	3
angiotensin ii and the	3
in experimental heart failure	3
that included hypertensive patients	3
benefits of ace inhibitors	3
severe critical outcomes in	3
the spontaneously hypertensive rat	3
mechanism of lung injury	3
online version of this	3
respiratory syndrome coronavirus and	3
induced vsmc senescence via	3
cardiovascular and renal physiology	3
enzyme in diabetic nephropathy	3
immune responses to viral	3
the discovery of renin	3
aceis arbs and severe	3
ang ii can be	3
the yeast pdr gene	3
loss of ace due	3
transformed into sky and	3
not differ between normal	3
the elderly and those	3
with the ace inhibitor	3
in order to function	3
two axes of the	3
vasodilatation and revision of	3
an increased risk of	3
ace activation promotes antithrombotic	3
and death in patients	3
targeting ras to the	3
spike in the prefusion	3
activation of the mas	3
identified throughout the gastrointestinal	3
mellitus at increased risk	3
induced by testosterone deficiency	3
a direct renin inhibitor	3
system inhibitors and covid	3
as a viral functional	3
of the glomerular filtration	3
in metabolic and inflammatory	3
patients with hypertension and	3
is activated by angii	3
chronic pulmonary disease is	3
activation of the protective	3
these data suggest that	3
m a n u	3
that aceis and arbs	3
of human angiotensin i	3
increased risk of mortality	3
regulators for bone metabolism	3
of sky and sky	3
of angiotensin ii in	3
to those of ang	3
signaling in the vasculature	3
activation of circulating or	3
ii receptor subtypes in	3
introduction of renin inhibitors	3
while the abundance of	3
in patients with pulmonary	3
of the map kinase	3
entry and its immune	3
the level of ang	3
angiotensin system be withdrawn	3
significant difference with regards	3
authors declare no conflict	3
peptides by human angiotensin	3
expression of cd in	3
in times of covid	3
proteins of severe acute	3
is an open access	3
is available to authorized	3
to be mediated through	3
clinical trial of recombinant	3
for patients with covid	3
highly expressed in the	3
pressure in the spontaneously	3
between gut microbiota and	3
related to respiratory collapse	3
of at r and	3
and its association with	3
elevation of blood pressure	3
of an ace inhibitor	3
in the control of	3
ace mrna expression and	3
withdrawn in patients with	3
high levels of ace	3
allele was associated with	3
mmol l which is	3
of the ras is	3
effect of aceis arbs	3
ace is a carboxypeptidase	3
in the present study	3
in the human heart	3
affect the kidneys directly	3
activated protein kinase in	3
release of vasopressin from	3
smooth muscle cells via	3
may contribute to the	3
to specific receptors on	3
either ace inhibitors or	3
mediated ace shedding in	3
ace has emerged as	3
converting enzyme suppresses pathological	3
profound loss of the	3
ventricular fibrillation has been	3
in the prevention and	3
induced lung injury in	3
through activation of the	3
play upstream roles in	3
of middle east respiratory	3
amino acid from the	3
and cardiovascular effects of	3
production of nitric oxide	3
the glomerular slit diaphragm	3
chinese national health commission	3
on blood pressure and	3
and angiotensin ii type	3
pulmonary arterial hypertension a	3
a new member of	3
demonstrate that ras l	3
of the ras which	3
in the role of	3
the implications for the	3
of pneumonia associated with	3
at high risk of	3
use of acei arb	3
and the activation of	3
role of the ras	3
is also found in	3
a homologue of ace	3
virus entering host cells	3
the n domain of	3
throughout the gastrointestinal tract	3
is mediated by the	3
endoplasmic reticulum stress and	3
is responsible for the	3
ras in cardiovascular disease	3
ace as the receptor	3
angiotensin type i receptor	3
to the pathogenesis of	3
inflammation and oxidative stress	3
in patients with acute	3
a potential target for	3
are patients with hypertension	3
spike proteins of severe	3
activate signal transduction pathways	3
and reactive oxygen species	3
converting enzyme in diabetic	3
hypokalaemia compared to those	3
infusion of ang ii	3
risk of death in	3
type receptor and the	3
of at r expression	3
stress likely play upstream	3
the innate immune response	3
degradation of angiotensin ii	3
human recombinant ace reduces	3
growth of cardiac myocytes	3
association with the use	3
medical treatment expert group	3
fibrosis induced by ccl	3
this is a key	3
exerts its actions via	3
has been detected in	3
at r has been	3
all the components required	3
of oxidative stress and	3
binds to the mas	3
ratio of kidney weight	3
the effect of angiotensin	3
expressed at a moderate	3
of spontaneously hypertensive rats	3
and er stress likely	3
not be used in	3
been shown to upregulate	3
was used to detect	3
hypertension and cardiovascular diseases	3
used to detect the	3
which may explain the	3
which cells were pretreated	3
inhibits growth of cardiac	3
stimulation of at receptors	3
the impact of the	3
expression in lung tumor	3
is also associated with	3
ace ace balance is	3
mortality and disease severity	3
of the weight of	3
epub ahead of print	3
reactive oxygen species and	3
a significant reduction of	3
cardiac pathology in covid	3
in the apoe knockout	3
has been demonstrated to	3
role of nep in	3
membrane in order to	3
of the gut microbiota	3
revision of ventilatory support	3
in combination with the	3
a prospective cohort study	3
have higher levels of	3
angiotensin ii receptor antagonists	3
ii in the heart	3
hypertensive rats angiotensin ii	3
a type i transmembrane	3
acute lung injury by	3
treatment with at r	3
has not been reported	3
there is evidence of	3
which is thought to	3
fibrosis and oxidative stress	3
in the aorta of	3
that were limited to	3
is not surprising that	3
in the brains of	3
statistically significant after correction	3
the presence of an	3
after the antibiotic intervention	3
for those with myocardial	3
the balance of the	3
unclear if this is	3
but not angiotensin ii	3
and evolution of coronavirus	3
angiotensin ii angiotensin ii	3
in a family with	3
l which is the	3
the ras have been	3
insensitive carboxypeptidase a novel	3
the at receptor in	3
the role of neprilysin	3
severe critical illness in	3
enzyme in brain tissue	3
intrinsic proinflammatory signaling in	3
significant after correction for	3
of the unfolded protein	3
in patients with portal	3
and those with hypertension	3
k and map k	3
be generated from ang	3
to be taken into	3
is available regarding the	3
at the time of	3
in lung tumor cells	3
and apoptosis in podocytes	3
sky was sensitive to	3
with more severe disease	3
and ang ii are	3
there is evidence for	3
in the bile duct	3
aerosolization of viral particles	3
patients with chronic heart	3
angiotensin receptor blockers have	3
to activate signal transduction	3
the downregulation of ace	3
genetic ace deficiency accentuates	3
c r i p	3
outcomes among patients hospitalized	3
seen in patients with	3
and its immune cross	3
proximal metaphysis of tibia	3
are associated with the	3
on liver fibrosis in	3
upregulation of hepatic angiotensin	3
in favor of the	3
in maintaining the balance	3
feedback mechanism in the	3
of in situ immune	3
have been proposed to	3
have been attributed to	3
the risk of cancer	3
in the lung through	3
there is evidence that	3
by a variety of	3
which is associated with	3
the permeability of the	3
of coronavirus spike proteins	3
at r and a	3
mediated pathophysiology in cvds	3
a decoy peptide corresponding	3
characterization of spike glycoprotein	3
of ace inhibitors or	3
blood pressure regulation and	3
attenuates downregulation of angiotensin	3
which was associated with	3
hypertension in transgenic rats	3
the regulation of captopril	3
the effects of ras	3
outcomes in subjects with	3
in the ace and	3
from the plasma membrane	3
aceis arbs compared to	3
these drugs in covid	3
erk and p mapk	3
in a state of	3
cardiac myocytes through activation	3
the physiological and pathophysiological	3
effects in the cardiovascular	3
the ras in lung	3
rats effect of angiotensin	3
several lines of evidence	3
type receptor in human	3
found to be highly	3
with the dm group	3
of protein kinase b	3
the amount of ang	3
of the central nervous	3
roles in the ras	3
ras inhibitors in covid	3
the function of the	3
transforming signal transduction pathways	3
of the yeast pdr	3
treatment expert group for	3
we propose that covid	3
and diabetes mellitus at	3
mediated virus entering host	3
indirectly via proteolytic processing	3
model of type diabetes	3
effects of aceis and	3
as a homeostatic regulator	3
a pilot clinical trial	3
length human ace in	3
the main effector of	3
the ras system is	3
in wuhan clinical course	3
in the medical literature	3
of trabecular bone at	3
blood flow and oxygenation	3
syndrome during mechanical ventilation	3
to be a potent	3
a r and at	3
in ace null mice	3
with chronic kidney disease	3
of the discovery of	3
in pancreatic cancer cells	3
on vascular smooth muscle	3
proinflammatory signaling in podocytes	3
in patients with obstructive	3
the number of x	3
the at r has	3
of ventilatory support choices	3
of ace due to	3
patients with heart failure	3
the e protein of	3
in addition to an	3
has been suggested to	3
of a large number	3
system be withdrawn in	3
aberrant renin angiotensin system	3
as a target for	3
not lead to a	3
the at receptor can	3
of inhibitors of the	3
it has been previously	3
into the tubular lumen	3
as a novel target	3
actions of angiotensin ii	3
that ang ii is	3
with pulmonary arterial hypertension	3
in myocardial ischemia reperfusion	3
clinical characteristics of cases	3
respect to early anticoagulation	3
on renal function in	3
ace by the spike	3
different definitions of severe	3
generation of ang ii	3
mechanical stress and the	3
type ii transmembrane serine	3
accentuates vascular inflammation and	3
human ace structure of	3
the protective effects of	3
although it has been	3
of the three groups	3
group compared with that	3
an angiotensin ii type	3
a significantly reduced risk	3
of protein kinase c	3
patients with cardiovascular disease	3
is regulated by some	3
patients with pulmonary arterial	3
a disintegrin and metalloprotease	3
deposition of extracellular matrix	3
mediates diabetic renal injury	3
to be present in	3
role of neutral endopeptidase	3
angiotensin system blockade on	3
hypertension in patients with	3
for bone metabolism in	3
evolution of coronavirus spike	3
diabetes infected with covid	3
sodium and water reabsorption	3
blood pressure elevation and	3
patients with essential hypertension	3
formation of ang i	3
cells of the kidney	3
compared with that in	3
of angiotensin ii with	3
the formation of in	3
ang i into ang	3
the complexity of the	3
which are associated with	3
inflammation and atherosclerosis in	3
such as diabetes mellitus	3
the use of either	3
outcomes between acei arb	3
a wide array of	3
in china clinical characteristics	3
of arbs and acei	3
alveolar epithelial cell apoptosis	3
with at r blockers	3
of spike glycoprotein of	3
provided adjusted estimates for	3
cells were pretreated with	3
use of ace inhibitors	3
and function of podocytes	3
is known to cause	3
to kill tumor cells	3
adjusted estimates for severe	3
by the spike protein	3
in the cirrhotic liver	3
for prevention and treatment	3
formation of in situ	3
of ace as the	3
an experimental model of	3
specific intercellular adhesion molecule	3
on virus entry and	3
the proteolytic cleavage of	3
is the value required	3
acei arb was non	3
round of integrative transformation	3
are a number of	3
blockers and the covid	3
activation promotes antithrombotic activity	3
enzyme suppresses pathological hypertrophy	3
induced reactive oxygen species	3
relationship between gut microbiota	3
syndrome coronavirus spike protein	3
and the at r	3
inflammation in patients with	3
the ratio of kidney	3
in this study was	3
may account for the	3
has been described as	3
by the carboxypeptidase ace	3
the tmprss cleavage site	3
inhibition of ang ii	3
flow and oxygenation in	3
upstream roles in angii	3
between men and women	3
reabsorbed in the medullary	3
gene and protein expression	3
ventricular dysfunction in myocardial	3
in animal models and	3
increase of ang ii	3
and the immune system	3
neutral amino acids in	3
the importance of the	3
deeper understanding of the	3
and clinical characteristics of	3
of the ras by	3
converting enzyme inhibitory peptides	3
and smooth muscle cells	3
in experimental biliary fibrosis	3
enzyme in the late	3
may be attributed to	3
the context of the	3
under high glucose conditions	3
ii in vascular smooth	3
coronavirus pneumonia in wuhan	3
has a role in	3
and revision of ventilatory	3
increased risk for covid	3
in the late phase	3
of angiotensin receptor blockers	3
dm group was significantly	3
region for nonproteolytic activation	3
in the medullary collecting	3
and characterization of a	3
ang ii can also	3
available to authorized users	3
the apoe knockout mouse	3
blockade and risk of	3
wuhan clinical course and	3
diabetes mellitus at increased	3
role for at r	3
to the ace receptor	3
be one of the	3
correlated with the exposure	3
the ace receptor is	3
in addition to systemic	3
pulmonary blood flow and	3
has been shown that	3
value required for those	3
has been associated with	3
has been implicated in	3
converting enzyme in acute	3
mrna and protein expression	3
no significant difference in	3
the medullary collecting duct	3
human ace in complex	3
circulating or local ras	3
nep was reported to	3
of ras inhibitors in	3
expert group for covid	3
observed no significant association	3
under the stimulation of	3
high expression of ace	3
role in the development	3
diabetes and cardiovascular disease	3
response to high glucose	3
middle cerebral artery occlusion	3
the late phase of	3
we systematically reviewed the	3
that there was a	3
to those with hyperkalaemia	3
of the actin cytoskeleton	3
the incidence of ventricular	3
of ventricular dysfunction in	3
which is the value	3
did not differ between	3
typical acute respiratory distress	3
characterization of renal angiotensin	3
clinical outcomes in subjects	3
phase ii clinical trials	3
the reninangiotensin system and	3
the transtubular potassium gradient	3
it is interesting to	3
by removing the c	3
reports have demonstrated that	3
the modulation of captopril	3
we suggest that nep	3
angiotensin system inhibitors in	3
and the united states	3
level of ang ii	3
electrosurgical and ultrasonic devices	3
receptor blockers and angiotensin	3
th anniversary of the	3
e protein of avian	3
of the ras receptors	3
acid transporter b at	3
differences in disease severity	3
a deeper understanding of	3
for the novel coronavirus	3
of aceis arbs compared	3
induced vascular senescence and	3
endothelial and smooth muscle	3
a compensatory increase in	3
does not lead to	3
transmembrane domain of the	3
with hypokalaemia compared to	3
system in cardiovascular disease	3
at risk of severe	3
with ace inhibitors and	3
the discovery of the	3
the online version of	3
pathogenesis of severe acute	3
injury in patients with	3
pilot clinical trial of	3
peptide corresponding to the	3
states such as diabetes	3
is a receptor for	3
of randomised controlled trials	3
of the ras axis	3
to the disruption of	3
in situ immune complexes	3
the involvement of the	3
from the use of	3
treated with slgt inhibitors	3
vascular endothelial and smooth	3
and intrarenal ang ii	3
is due to the	3
a homeostatic regulator of	3
the at receptor gene	3
should inhibitors of the	3
smooth muscle cell senescence	3
acei arb relative to	3
effects of ras blockade	3
the results of the	3
is then cleaved by	3
that there is no	3
with chronic heart failure	3
decoy peptide corresponding to	3
in the nucleus tractus	3
thought to be the	3
an acei arb relative	3
the dm group compared	3
incidence of ventricular fibrillation	3
sex differences in immune	3
with mortality among patients	3
high level of expression	3
amino acid transporter b	3
is a type i	3
antithrombotic effect of angiotensin	3
new roles in inflammation	3
china medical treatment expert	3
of pathological cardiac hypertrophy	3
arbs and severe critical	3
ii receptor blockers in	3
diagnostic and therapeutic intervention	3
that of carboxypeptidase a	3
risk of mortality and	3
u s c r	3
has been identified in	3
blood pressure control and	3
the introduction of renin	3
proven to be effective	3
late phase of ventricular	3
role of the ace	3
treatment of patients with	3
the rate of ang	3
generation of reactive oxygen	3
ncov spike in the	3
in order to determine	3
minimum distance from the	3
at r or masr	3
metabolism of ang ii	3
of the ras have	3
of diabetic nephropathy by	3
ras is activated in	3
with or without hypertension	3
activation of nadph oxidase	3
fibrillation has been shown	3
the pi k pathway	3
vasopressin from the rat	3
ii transmembrane serine proteases	3
play a key role	3
a reduced risk of	3
pathways of the renin	3
ii by aminopeptidase a	3
be taken into account	3
as it relates to	3
are not required for	3
converting enzyme by the	3
over the last years	3
and acute kidney injury	3
cleavage of ang i	3
nicotinamide adenine dinucleotide phosphate	3
a typical acute respiratory	3
in the metabolism of	3
from ang ii to	3
production and facilitates viral	3
ncov on the epithelial	3
levels are associated with	3
the active site cleft	3
protective role of ace	3
phase of ventricular dysfunction	3
virus entry and its	3
the level of expression	3
patients at high risk	3
the two axes of	3
dysfunction in myocardial infarcted	3
hf with preserved ejection	3
arb relative to the	3
the novel coronavirus from	3
fluid and electrolyte absorption	3
risk of severe or	3
pressure and renal function	3
senescence of vascular smooth	3
clinical characteristics of covid	3
the catalytic activity of	3
converting enzyme inhibitor on	3
a novel therapeutic target	3
there is increasing evidence	3
the severity of the	3
in an experimental model	3
ang ii to the	3
the weight of the	3
given that ace is	3
ace functions as a	3
and an increase in	3
was significantly associated with	3
ang ii by aminopeptidase	3
the antithrombotic effect of	3
the explanation for this	3
subjects with diabetes infected	3
the value required for	3
levels in experimental biliary	3
severity or risk of	3
with ace related multi	3
therapeutic target for cardiovascular	3
one of the major	3
differ between normal lung	3
patients with severe acute	3
of mortality in covid	3
of studies that provided	3
fulminant hypertension in transgenic	3
a potential pharmacological candidate	3
reproduction in any medium	3
have a greater role	3
with lower risk of	3
cleaved by ace to	3
no obvious feedback activation	3
studies that included hypertensive	3
infarction increases ace expression	3
and the ratio of	3
that there may be	3
underrepresented in the group	3
significantly reduced risk of	3
was digested with aatii	3
the secretion of renin	3
it was not until	3
and apoptosis in the	3
mental retardation and epilepsy	3
heart failure with reduced	3
length human ace structure	3
compared to ras l	3
potential effect of captopril	3
of at r promotes	3
ace mrna and protein	3
pathological changes in the	3
converting enzyme in experimental	3
a large body of	3
of renin angiotensin system	3
er stress likely play	3
by the spike proteins	3
of prr in the	3
if this is a	3
induced senescence in vascular	3
r and masr agonists	3
recombinant ace reduces the	3
be closely related to	3
is also involved in	3
the th anniversary of	3
a small gtpase rac	3
angiotensin system blockers and	3
expression of angiotensin ii	3
with the exposure time	3
the development of dn	3
is a negative regulator	3
in human vascular smooth	3
that inhibition of the	3
were randomly divided into	3
vascular inflammation and atherosclerosis	3
enalapril attenuates downregulation of	3
treatment of cardiovascular disease	3
circular and longitudinal muscle	3
for nonproteolytic activation of	3
enzyme in acute respiratory	3
the experiments to test	2
mechanism in acute kidney	2
gene i d polymorphism	2
and the phenotype alterations	2
a baculovirus expression system	2
unprecedented global morbidity and	2
of angiotensin iii in	2
original studies that provided	2
not increase the risk	2
has been suggested by	2
mas receptor axis is	2
of a duplicated gene	2
pathogenic actions of angiotensin	2
hospital death of patients	2
inhibition attenuates the progression	2
role against cardiovascular events	2
precipitated our interest in	2
but is also found	2
an important stress hormone	2
of cellular senescence via	2
an overly activated ras	2
at r agonist c	2
of the rate of	2
they are responsible for	2
blood pressure and exploratory	2
an arb or an	2
are new opportunities to	2
sarcoidosis and other granulomatous	2
coronavirus modulation of myocardial	2
instead only the association	2
with cardiovascular disease and	2
acute respiratory syndrome than	2
results in decreased expression	2
arbs reduce lung cancer	2
in ras wt samples	2
and the dm ab	2
of the caax box	2
natural stem cell regulator	2
the virus and the	2
microbiota and ras activation	2
in mice the angiotensin	2
model of hypertension derived	2
have shown that in	2
engineered human tissues using	2
may mean that senescence	2
interventions are not directed	2
activation and abrogated the	2
propria mesenchymal cells and	2
receptor antagonist candesartan as	2
been identified as being	2
cirrhosis and portal hypertension	2
postmenopausal females in turn	2
and er stress are	2
regarding the contribution of	2
but there was no	2
tt region from pyes	2
effects and clinical implications	2
both in vitro and	2
have the potential to	2
polymorphism further support the	2
therapeutic agents in covid	2
reveals the potential risk	2
which serves as the	2
located on the x	2
receptor binding domain of	2
intraperitoneally injected with streptozotocin	2
for angiotensin converting enzyme	2
the treatment of human	2
cleaves angii and ang	2
if targeted to the	2
and diseases are still	2
of in vitro and	2
in the face of	2
are not technically separated	2
angiotensinogen to ang i	2
been considered to be	2
genes for two enzymes	2
the coexistence of inherited	2
partial pressure of oxygen	2
into the systemic circulation	2
different extents of adjustment	2
towards the pathophysiology of	2
with a modulation of	2
previous studies have shown	2
the authors concluded that	2
activation of the intrarenal	2
and blood cancer cells	2
expression ratio of osteoprotegerin	2
in rats angiotensin ii	2
research on the potential	2
patients with t dm	2
are the highest in	2
and receptor activator of	2
at and the at	2
at r and healthspan	2
exceptions and the exact	2
ros and results in	2
enzyme protein expression by	2
ras actions including cell	2
likely to have hypertension	2
blood pressure in transgenic	2
drugs and risk of	2
chloride intracellular channel a	2
reiterating that we need	2
we and others have	2
high mobility group box	2
enhancement in the activity	2
blockade on a new	2
pathway in response to	2
drugs used in co	2
mice lacking angiotensin ii	2
an open access article	2
diabetic retinopathy in mice	2
akita or akita mice	2
direct endothelial cell damage	2
by angii was observed	2
with elevated plasma bacterial	2
blood pressure elevation in	2
acute lung failure in	2
of the ras was	2
at the atomic level	2
case series of patients	2
of receptor recognition by	2
might favor virus membrane	2
an increase in benefit	2
more sensitive to the	2
to the late development	2
angiotensin ii induces smooth	2
new congenic model of	2
of large gene lists	2
authentic angiotensin ii in	2
ameliorates cardiac dysfunction observed	2
namely severe acute respiratory	2
ace inhibitors or angiotensin	2
lifespan can be extended	2
mechanisms contributing to arterial	2
office of minority health	2
decrease the amount of	2
in a decrease in	2
in the golgi compartment	2
or agonists of the	2
ang ii and other	2
which simulate human premature	2
its influence in gastrointestinal	2
ros production is activated	2
of acute severe pneumonia	2
permeability of the filtration	2
podocyte injury and proteinuria	2
with the progression of	2
unexpected aspects of covid	2
preferred reporting items for	2
by interacting with the	2
suggested in the at	2
with one of the	2
which may contribute to	2
although the exact mechanism	2
a treatment of covid	2
that in senescence accelerated	2
antagonists are the most	2
patients with cvd and	2
renin prorenin receptor prepared	2
data that may be	2
expression by human coronavirus	2
glucose and lipid metabolism	2
provided adjusted estimates and	2
and clinical studies of	2
for hypertension and other	2
the therapeutic potential of	2
key roles in the	2
is mediated by tace	2
excreted into the tubular	2
we were also able	2
of the exposed cohort	2
the pathogenesis of glomerulosclerosis	2
via integration with the	2
used for the quality	2
with the reduction of	2
no specific recommendations are	2
in normotensive lewis rats	2
receptor might contribute by	2
between the virus and	2
full text free full	2
of inherited predispositions or	2
with severe liver disease	2
ace is a zinc	2
it was reasoned that	2
immunologic effects of the	2
management of patients with	2
an in vivo study	2
in human pulmonary arterial	2
protective effects of the	2
of ras blockade on	2
angii was observed in	2
that reported mortality outcomes	2
renin receptors has made	2
potential role in cardiac	2
in keeping with this	2
juxtaglomerular cells of the	2
abrogated the downregulation of	2
the extracellular space of	2
and beyond the renin	2
lifespan of our population	2
genes homo sapiens kegg	2
limited whereas the condition	2
according to the assay	2
that occur in the	2
saci and the purified	2
activation of the at	2
ii type receptor agonist	2
actions including cell growth	2
angiotensinogen gene is expressed	2
are more susceptible to	2
the degree of proteinuria	2
as well as il	2
basis of receptor recognition	2
funnel plot was used	2
signaling events and whether	2
likely to die from	2
expression and activity of	2
axis in inflammation and	2
and endoplasmic reticulum stress	2
term use of arb	2
progression of podocyte injury	2
patients with vascular disease	2
ace and ace cooperate	2
is in line with	2
an appropriate level of	2
the initial drug development	2
immense threat to healthcare	2
further towards the c	2
the therapeutic role of	2
the ace i d	2
regulation of ace expression	2
as a pharmaceutical target	2
lead to increased capillary	2
is an important complication	2
through the apelin receptors	2
worsens glomerular injury in	2
with age in rodents	2
different to almost all	2
shown that ang ii	2
the vascular system is	2
studies are needed to	2
role in a variety	2
significant association between the	2
renin to the recombinant	2
by a combination of	2
by grants from the	2
care units with the	2
of rat hepatic fibrosis	2
map k serine threonine	2
actions similar to those	2
in the action of	2
been reported to promote	2
even intestinal ischaemia have	2
of severe disease and	2
terminus of ras proteins	2
the ras raf mek	2
system inhibitors with severity	2
flt to gm plays	2
one of the following	2
and transfected the following	2
with vascular disease or	2
in inflammation and fibrosis	2
been considered one of	2
low level and its	2
cell proliferation in the	2
lung fibrosis by inhibiting	2
number of physiological processes	2
individuals with diabetes infected	2
of both the sars	2
renal and cardiac tissue	2
mutation in a family	2
be a new target	2
pleiotropic regulator of the	2
obesity while enhancing insulin	2
in patients with vascular	2
was significantly increased compared	2
the trabecular bone area	2
been encouraging to date	2
relevance in the angii	2
regulates the activity of	2
from the gut microbiota	2
with all the components	2
pronounced in disease conditions	2
recent advances in the	2
environment is not sucient	2
we have shown that	2
found that the expression	2
to icus of the	2
to cells precipitated our	2
and temporal changes of	2
of the ace ectodomain	2
for women than for	2
higher mortality for invasively	2
ace g a polymorphism	2
that our model stimulates	2
essential roles in autocrine	2
degree of heterodimer assembling	2
stress and the induction	2
and nucleotide exchange activities	2
permeability of the yeast	2
more translational research is	2
significantly increased compared with	2
hypoxia and er stress	2
the development of salt	2
this study was referred	2
been shown to impact	2
society of european robotic	2
terms and conditions of	2
by a baculovirus expression	2
cytokines and chemokines in	2
that ras inhibitors may	2
as an average of	2
role for the renin	2
to the proper lengths	2
clinical and experimental evidence	2
peptidoglycans enhancing systemic inflammation	2
that pharmacological inhibition of	2
international clinical trials registry	2
ace in the heart	2
ii in the plasma	2
ace gene do not	2
and or peptidoglycans enhancing	2
diversity analysis was performed	2
of hypertension and diabetes	2
inducing muscle senescence via	2
and inflammation in patients	2
damage in several organs	2
midas vsmc produce altered	2
disease conditions with ras	2
respiratory distress syndrome recombinant	2
the destruction of alveoli	2
their mutual expression levels	2
from the genetic analysis	2
constructed by replacing the	2
in serum markers of	2
expression of nephrin in	2
ace expression at the	2
play important roles in	2
to the severe acute	2
media that lacked uracil	2
aect the ability of	2
can be generated from	2
development of hypertension in	2
it may be useful	2
acute hypoxic pulmonary vasoconstriction	2
caused by ang ii	2
entry and local pulmonary	2
in engineered human tissues	2
and arbs has been	2
lines of evidence support	2
role in the regulation	2
in those infected with	2
deficiency leads to enhanced	2
and protects against diabetic	2
human intestine luminal ace	2
inflammatory responses in aged	2
recent discovery of renin	2
coated with rabbit a	2
no evidence to abandon	2
lung injury provides an	2
system and its role	2
the next round of	2
protein levels and activity	2
to increased capillary permeability	2
mediated through several signaling	2
bone as well as	2
complexity of the ras	2
the observation that the	2
loss of ace increases	2
accelerates maladaptive left ventricular	2
cytokine profile related to	2
the immune system and	2
by ang ii and	2
imbalance of the renin	2
presence of heterogeneity in	2
show instead only the	2
at r biased agonists	2
in glomerular endothelium glycocalyx	2
expression and inflammation in	2
of overstimulation of at	2
entry into the host	2
which has been shown	2
cytokines such as tnf	2
mediated by tace adam	2
in glomerular filtration barrier	2
muscle cell proliferation in	2
system in heart failure	2
and pathophysiology including vasoconstriction	2
expression of angiotensin receptors	2
plays a critical role	2
generally counteracts the classical	2
and ang i into	2
vasoconstriction and increase blood	2
its extracellular domain shedding	2
the urgency to study	2
cleavage of ace by	2
mrna expression and activity	2
the expression of b	2
r or masr inhibits	2
been examined in a	2
potential risk of different	2
organ damage of this	2