This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.
| identifier | question |
|---|---|
| cord-006439-q7m4srvp | New technologies are making it easier to answer old questions- what is the localization of angiotensin receptors- and investigate new ones- what are function of specific subsets of AT 1 R- containng neurons? |
| cord-006439-q7m4srvp | provides a novel look at angiotensin type-2 receptor distribution in the central nervous system A unique"angiotensin- sensitive"neuronal population coordinates neuroendocrine, cardiovascular, and behavioral responses to stress Expression of AT2 receptors in the developing rat fetus Tonin expression in the rat brain and toninmediated central production of angiotensin II Extrarenal angiotensin- forming enzymes Angiotensin generation in the brain and drinking: indications for the involvement of endopeptidase activity distinct from cathepsin D Chronic immunoneutralization of brain angiotensin-(1- 12) lowers blood pressure in transgenic( mRen2)27 hypertensive rats Brain renin- angiotensin system: does it exist? |
| cord-276260-iccaqz8u | Is the use of RAS inhibitors safe in the current era of COVID-19 pandemic? |
| cord-276260-iccaqz8u | Namsolleck, Pawel; Moll, Gert N. title: Does activation of the protective Renin- Angiotensin System have therapeutic potential in COVID-19? |
| cord-276260-iccaqz8u | Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis Angiotensin-(1- 7) and the regulation of antifibrotic signaling pathways COVID-19 and RAS: Unravelling an unclear relationship Cardioprotective angiotensin-(1- 7) peptide acts as a natural- biased ligand at the angiotensin II type 1 receptor COVID-19 as a viral functional ACE2 deficiency disorder with ACE2 related multi- organ disease Contentious issues and evolving concepts in the clinical presentation and management of patients with COVID-19 infection with reference to use of therapeutic and other drugs used in co- morbid diseases A potential therapeutic role for Angiotensin Converting Enzyme 2 in human pulmonary arterial hypertension Endothelial cell dysfunction: a major player in SARS- CoV-2 infection( COVID-19)? |
| cord-277766-rxmpi61o | The( pro)renin receptor: a new addition to the renin- angiotensin system? |
| cord-007707-c38fu1jv | Any value of podocyte B7- 1 as a biomarker in human MCD and FSGS? |
| cord-007707-c38fu1jv | The podocyte's response to injury: role in proteinuria and glomerulosclerosis Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1 Minimal change disease: a"two- hit"podocyte immune disorder? |
| cord-007707-c38fu1jv | in angiotensin II- induced reactive oxygen species generation and podocyte apoptosis Epithelial- to- mesenchymal transition in diabetic nephropathy: fact or fiction? |
| cord-007707-c38fu1jv | the culprit? |
| cord-257558-dgnbfzli | So how does this relate to COVID-19? |
| cord-002632-6he8sjpf | An FDA overview of rodent carcinogenicity studies of angiotensin II AT-1 receptor blockers: pulmonary adenomas and carcinomas Renin- angiotensin system blockade for the risk of cancer and death Angiotensin receptor blockers( ARBs) reduce the risk of lung cancer: a systematic review and meta- analysis Long term use of drugs affecting the renin- angiotensin system and the risk of cancer: a population- based case- control study Angiotensin receptor blockers: are they related to lung cancer? |
| cord-002632-6he8sjpf | Angiotensin receptors: a new role in cancer? |
| cord-002632-6he8sjpf | The reninangiotensin system and cancer: old dog, new tricks G- protein coupled receptors of the renin- angiotensin system: New targets against breast cancer? |
| cord-289905-dvl2pud2 | COVID-19 pneumonia: ARDS or not? |
| cord-289905-dvl2pud2 | COVID-19 pneumonia: different respiratory treatments for different phenotypes? |
| cord-289905-dvl2pud2 | T Unger, UM Steckelings and RAS dos Santos Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-005931-iggkxbbf | Alcohol intake ANG II induces drinking, but does it induce alcohol drinking? |
| cord-005931-iggkxbbf | But, what about renin? |
| cord-298490-p1msabl5 | Human intestine luminal ACE2 and amino acid transporter expression increased by ACE- inhibitors Imbalance of the renin- angiotensin system may contribute to inflammation and fibrosis in IBD: a novel therapeutic target? |
| cord-280662-gakayv6e | an update on mechanisms of physiology and pathophysiology Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-012837-fuwp08qt | The bread and butter of the microbiota- gutbrain axis? |
| cord-259243-1lkzcslx | And, would the use of SLGT2 inhibitors in non- diabetic patients improve clinical prognosis as well? |
| cord-259243-1lkzcslx | Hence, would diabetic patients with CVD and treated with SLGT2 inhibitors present a milder ARDS as compared to those with a different treatment? |
| cord-259243-1lkzcslx | Would they have a better clinical prognosis? |
| cord-303555-mwu72q7w | A Crucial Role in the Action of Insulin, EGF, and pp60src? |
| cord-303555-mwu72q7w | The MEK Kinases MEKK4/ Ssk2p Facilitate Complexity in the Stress Signaling Responses of Diverse Systems Upstream Regulators of the c- Jun Amino- Terminal Kinases? |
| cord-303555-mwu72q7w | The first question the academic investigator should ask is, in their hands, does the dose- response effect on tumor cell growth/ viability correspond to the claimed inhibitory IC50 of the compound against its purified specific target? |
| cord-303555-mwu72q7w | The first thing the independent academic collaborator needs to know is what was the highest safe dose of the compounds used in prior mouse studies? |
| cord-335076-mmpox655 | New approaches to blockade of the reninangiotensin- aldosterone system: chymase as an important target to prevent organ damage Endothelial dysfunction: a strategic target in the treatment of hypertension? |
| cord-351875-e4aw7gkd | In healthy subjects at risk, evidence is not( yet?) |
| cord-311099-59pnm4fn | ACE inhibition Gradual reactivation of vascular angiotensin I to angiotensin II conversion during chronic ACE inhibitor therapy in patients with diabetes mellitus Determinants of increased angiotensin II levels in severe chronic heart failure patients despite ACE inhibition How often are angiotensin II and aldosterone concentrations raised during chronic ACE inhibitor treatment in cardiac failure? |
| cord-311099-59pnm4fn | Bradykinin, angiotensin-(1- 7), and ACE inhibitors: how do they interact? |
| cord-311099-59pnm4fn | Liver fibrosis: a balance of ACEs? |
| cord-269289-6uog10j4 | A few small studies have demonstrated that SARS- CoV-2 can affect the kidneys directly, but it is unclear if this is a key mechanism in acute kidney injury seen in patients with SARS- CoV-2 infection? |
| cord-269289-6uog10j4 | This study claimed that hypokalaemia was prevalent amongst SARS- CoV-2 infected patients, affecting 108 of 175 patients( 62%) that had a serum potassium of 4.0 mmol/ l which is the value required for those with myocardial dysfunction.Hypokalaemia affected 62% of patients with a K less than 3.5? |
| cord-269289-6uog10j4 | Are all factual statements correct and adequately supported by citations? |
| cord-269289-6uog10j4 | Does this significantly alter management in these patients, outside of a research context? |
| cord-269289-6uog10j4 | Partly Are arguments sufficiently supported by evidence from the published literature? |
| cord-269289-6uog10j4 | What is the evidence for hypokalaemia in SARS- CoV-2 infection so far? |
| cord-324364-9p04oeac | CARDIOVID registry Is the use of ACE inb/ ARBs associated with higher in- hospital mortality in Covid-19 pneumonia patients? |
| cord-324364-9p04oeac | Could anti- hypertensive drug therapy affect the clinical prognosis of hypertensive patients with COVID-19 infection? |
| cord-324364-9p04oeac | a retrospective cohort study Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China Association of cardiac injury with mortality in hospitalized patients with COVID-19 in Wuhan, China Cardiovascular implications of fatal outcomes of patients with coronavirus disease 2019( COVID-19) COVID-19 and the cardiovascular system Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-344012-npob20n0 | A first step in understanding SARS pathogenesis Restructuring of the gut microbiome by intermittent fasting prevents retinopathy and prolongs survival in db/ db mice Microbiome and diabetes: where are we now? |
| cord-344012-npob20n0 | COVID-19) A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person- to- person transmission: a study of a family cluster Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome Enteric involvement of severe acute respiratory syndrome- associated coronavirus infection Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus Brain- gut- bone marrow axis: implications for hypertension and related therapeutics Prolonged presence of Sars- CoV-2 viral rna in faecal samples Enteric involvement of coronaviruses: is faecaloral transmission of SARS- CoV-2 possible? |
| cord-344012-npob20n0 | The renin- angiotensin system: going beyond the classical paradigms Emerging evidence for a functional angiotensin- converting enzyme 2-angiotensin-(1- 7)-MAS receptor axis: more than regulation of blood pressure? |
| cord-344012-npob20n0 | should inhibitors of the renin- angiotensin system be withdrawn in patients with covid-19? |
| cord-328846-q52fjx99 | Is cardiovascular aging a disease? |
| cord-328846-q52fjx99 | Mice Angiotensin- converting enzyme deletion allele is beneficial for the longevity of Europeans Variations of the angiotensin II type 1 receptor gene are associated with extreme human longevity Angiotensin II blockade: A strategy to slow ageing by protecting mitochondria? |
| cord-328846-q52fjx99 | What's aging? |
| cord-318327-9sh2eksm | Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin- angiotensin system in myocardial infarction? |
| cord-318327-9sh2eksm | Do inhibitors of angiotensin- Iconverting enzyme protect against risk of cancer? |
| cord-318327-9sh2eksm | Quantitative analysis by the polymerase chain reaction Angiotensin and cell growth: a link to cardiovascular hypertrophy? |
| cord-318327-9sh2eksm | myocardial ischemia/ reperfusion Angiotensin-(1- 7) inhibits growth of cardiac myocytes through activation of the mas receptor Emerging evidence for a functional angiotensin- converting enzyme 2-angiotensin-(1- 7)-MAS receptor axis: more than regulation of blood pressure? |
| cord-322966-o65fo853 | Circulating ACE-2 activity correlated with cardiovascular disease development Reninangiotensin- aldosterone system inhibitors in patients with COVID-19 COVID-19 and angiotensin- converting enzyme inhibitors and angiotensin receptor blockers: what is the evidence? |
| cord-322966-o65fo853 | Could these drugs – which include angiotensin converting enzyme inhibitors( ACEIs) and angiotensin receptors blockers( ARBs) – be harmful or potential key therapeutic agents in COVID-19? |
| cord-322966-o65fo853 | Could these drugs-which include angiotensin converting enzyme inhibitors( ACEIs) and angiotensin receptors blockers( ARBs)-be harmful or potential key therapeutic agents in COVID- 19? |
| cord-322966-o65fo853 | Implications for lipid metabolism remodelling upon coronavirus replication Lysophosphatidylinositol signalling and metabolic diseases Chronic widespread musculoskeletal pain, fatigue, depression and disordered sleep in chronic post- SARS syndrome; a case- controlled study Altered lipid metabolism in recovered SARS patients twelve years after infection Long term bone and lung consequences associated with hospital-acquired severe acute respiratory syndrome: a 15 year follow- up from a prospective cohort study Autoantibodies against human epithelial cells and endothelial cells after severe acute respiratory syndrome( SARS)-associated coronavirus infection Are vitamin D receptor agonists like angiotensin- converting enzyme inhibitors without side effects? |
| cord-322966-o65fo853 | Why do 81% of cases have a mild disease and yet 19% have a more severe disease? |
| cord-322966-o65fo853 | do angiotensin- converting enzyme inhibitors/ angiotensin receptor blockers have a biphasic effect? |
| cord-322966-o65fo853 | key: cord-322966-o65fo853 authors: Arnold, Ruth H. title: COVID-19 – Does This Disease Kill Due to Imbalance of the Renin Angiotensin System( RAS) Caused by Genetic and Gender Differences in the Response to Viral ACE 2 Attacks? date: 2020- 05- 25 journal: Heart Lung Circ DOI: 10.1016/ |
| cord-326498-8oa5gkrp | A novel prognostic biomarker? |
| cord-326498-8oa5gkrp | Another co- evolutionary adaptation? |
| cord-326498-8oa5gkrp | Compared to the Single X- Chromosome in Males? |
| cord-326498-8oa5gkrp | Do men have a higher case fatality rate of severe acute respiratory syndrome than women do? |
| cord-326498-8oa5gkrp | Is Nicotine the Hidden Link? |
| cord-326498-8oa5gkrp | The international imperative to rapidly and inexpensively monitor community- wide Covid-19 infection status and trends Shelter hospital mode: How to prevent novel coronavirus infection 2019( COVID-19) hospital- acquired infection? |
| cord-326498-8oa5gkrp | The tobacco industry in the time of COVID-19: Time to shut it down? |
| cord-313664-qq0h68vc | Arterial aging: is it an immutable cardiovascular risk factor? |
| cord-313664-qq0h68vc | Many questions are also raised, for instance, what would the consequences be if the'beneficial'angiotensin peptide, Ang 1- 7 was not generated at all or'benefical'AT2 receptor mediated effects disappeared completely? |
| cord-313664-qq0h68vc | Novel drugs targeting hypertension: renin inhibitors and beyond Dual blockade of the renin- angiotensin system with angiotensin- converting enzyme inhibitors and angiotensin II receptor blockers in chronic kidney disease Telmisartan, ramipril or both in patients at high risk for vascular events Antidiabetic mechanisms of angiotensin- converting enzyme inhibitors and angiotensin II receptor antagonists: beyond the renin- angiotensin system Renin inhibition with aliskiren: where are we now and where are we going? |
| cord-313664-qq0h68vc | Part of genetic reprogramming? |
| cord-313664-qq0h68vc | The adipose- tissue renin- angiotensin- aldosterone system: role in the metabolic syndrome? |
| cord-313664-qq0h68vc | angiotensin II- dependent or-independent mechanisms? |
| cord-317878-bqpj0ey0 | Do men have a higher case fatality rate of severe acute respiratory syndrome than women do? |
| cord-317878-bqpj0ey0 | From kinetics to dynamics: are there differences between ACE inhibitors? |
| cord-317878-bqpj0ey0 | Implications to myocardial ischemia Interaction between angiotensin type 1, type 2, and Mas receptors to regulate adult neurogenesis in the brain ventricular- subventricular zone Expression of renin- angiotensin system components in the taste organ of mice COVID-19 does not lead to a"typical"acute respiratory distress syndrome Acute respiratory distress syndrome Acute respiratory distress syndrome: an update and review COVID-19 pneumonia: ARDS or not? |
| cord-317878-bqpj0ey0 | Intrarenal renin- angiotensin system: locally synthesized or taken up via endocytosis? |
| cord-317878-bqpj0ey0 | The coming of age of the angiotensin hypothesis in Alzheimer's disease: progress toward disease prevention and treatment? |
| cord-317878-bqpj0ey0 | When? |
| cord-317878-bqpj0ey0 | Which one to give? |
| cord-317878-bqpj0ey0 | Why a fast blood glucose control should be mandatory Hypertension in the African American population: a succinct look at its epidemiology, pathogenesis, and therapy Office of minority health obesity and African Americans Differences in hypertension between blacks and whites: an overview Angiotensinogen and blood pressure among blacks: findings from a community survey in Jamaica African Americans, hypertension and the renin angiotensin system Is hypertension in African- descent populations contributed to by an imbalance in the activities of the ACE2/ Ang-(1- 7)/Mas and the ACE/ Ang II/ AT 1 axes? |
| cord-317878-bqpj0ey0 | Why? |
| cord-317878-bqpj0ey0 | inhibitors of the renin- angiotensin system be withdrawn in patients with COVID-19? |
| cord-317878-bqpj0ey0 | inhibitors/ angiotensin receptor blockers have a biphasic effect? |
| cord-317878-bqpj0ey0 | patients so severely hypoxemic in the first place? |
| cord-349445-yh6ndtgm | : What Is the Evidence? |
| cord-349445-yh6ndtgm | Are certain drugs associated with enhanced mortality in COVID-19? |
| cord-349445-yh6ndtgm | COVID-19: Epidemiology, Evolution, and Cross- Disciplinary Perspectives COVID-19 and the Renin- Angiotensin System SARS- CoV2: should inhibitors of the renin- angiotensin system be withdrawn in patients with COVID-19? |
| cord-349445-yh6ndtgm | Close to a Cure? |
| cord-349445-yh6ndtgm | Covid-19 Can angiotensin receptor- blocking drugs perhaps be harmful in the COVID-19 pandemic? |
| cord-349445-yh6ndtgm | Evidence- Based Med New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? |
| cord-349445-yh6ndtgm | Hence, the question now, may the reviewed actions of NEP pathways be sufficient to impose a new effective strategy for COVID-19 management as compared to the suggested repurposed drugs? |
| cord-349445-yh6ndtgm | Modulators of inflammation in acute lung injury? |
| cord-349445-yh6ndtgm | Neprilysin inhibition: a new therapeutic option for type 2 diabetes? |
| cord-349445-yh6ndtgm | Role in reducing β- amyloid levels Estrogen regulation of the neprilysin gene through a hormone- responsive element Influence of Selected Natural Products on Neutral Endopeptidase Activity and β- Amyloid Production in SK- N- SH Cells Possible role of Resveratrol targeting Estradiol and Neprilysin pathways in Lipopolysaccharide model of Alzheimer disease Epigallocatechin-3-gallate attenuates cognitive deterioration in Alzheimer's disease model mice by upregulating neprilysin expression Effects of Naoerkang on expressions of β- amyloid peptide 1- 42 and neprilysin in hippocampus in a rat model of Alzheimer's disease Decoding the enigma of antiviral crisis: Does one target molecule regulate all? |
| cord-349445-yh6ndtgm | So Far, Pathogens Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study COVID-19: consider cytokine storm syndromes and immunosuppression Correspondence Use of antiviral drugs to reduce COVID-19 Therapeutic options for the 2019 novel coronavirus( 2019-nCoV) Drug treatment options for the 2019-new coronavirus( 2019-nCoV) Molecular immune pathogenesis and diagnosis of COVID-19 Cytokinstormer ved covid-19? |
| cord-349445-yh6ndtgm | v2, ArXiv Prepr Acute respiratory distress syndrome leads to reduced ratio of ACE/ ACE2 activities and is prevented by angiotensin-(1- 7) or an angiotensin II receptor antagonist The Angiotensin- Converting Enzyme 2/ Angiogenesis-(1- 7)/Mas Axis Confers Cardiopulmonary Protection against Lung Fibrosis and Pulmonary Hypertension Decreased levels of serum Angiotensin-(1- 7) in patients with pulmonary arterial hypertension due to congenital heart disease Reninangiotensin- system, a potential pharmacological candidate, in acute respiratory distress syndrome during mechanical ventilation Dose- dependent, therapeutic potential of angiotensin-(1- 7) for the treatment of pulmonary arterial hypertension Angiotensin II type 2 receptor( AT2R) in renal and cardiovascular disease Angiotensin-(1- 7): A Novel Peptide to Treat Hypertension and Nephropathy in Diabetes? |