quadgram

This is a table of type quadgram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

quadgram	frequency
severe acute respiratory syndrome	100
of type i ifn	96
the innate immune response	95
has been shown to	88
type i ifn production	84
have been shown to	76
acute respiratory syndrome coronavirus	70
of type i interferon	67
the innate immune system	64
of type i ifns	63
the type i ifn	58
production of type i	58
in the absence of	58
type i ifn response	56
mitochondrial antiviral signaling protein	54
induction of type i	51
middle east respiratory syndrome	51
type i ifn signaling	50
in the regulation of	50
type i interferon production	49
the activation of the	48
the type i interferon	48
of hepatitis c virus	47
influenza a virus ns	47
on the other hand	47
by hepatitis c virus	46
porcine epidemic diarrhea virus	46
the production of type	44
east respiratory syndrome coronavirus	42
of interferon regulatory factor	42
of the innate immune	40
of the type i	40
been shown to be	39
antiviral innate immune response	37
in the recognition of	37
type i ifn induction	37
type i interferon signaling	37
by the innate immune	37
an important role in	36
the word w j	35
hepatitis c virus infection	35
in the activation of	35
in the context of	34
the category c k	34
the induction of type	34
innate immune response to	32
as well as the	32
is essential for rig	32
the production of ifn	32
type i and iii	32
in cells infected with	31
porcine reproductive and respiratory	30
type i interferon induction	30
identification and characterization of	29
of influenza a virus	29
a virus ns protein	29
reproductive and respiratory syndrome	29
expression of type i	28
viral rna sensor rig	28
the e ubiquitin ligase	28
in the induction of	28
play a role in	28
hepatitis c virus ns	27
it is possible that	27
in addition to the	27
in the case of	27
also been shown to	27
cells were transfected with	26
hepatitis c virus rna	26
hek t cells were	26
of mda and rig	26
the severe acute respiratory	26
of type i interferons	26
mediated type i interferon	26
a member of the	25
in antiviral innate immunity	25
i interferon production by	25
in hek t cells	25
innate immune response by	24
a negative regulator of	24
inhibits type i interferon	24
in type i ifn	24
for the activation of	24
and respiratory syndrome virus	24
i has an essential	24
human respiratory syncytial virus	24
in the presence of	24
it has been shown	24
the induction of ifn	23
and activator of transcription	23
transducer and activator of	23
the innate antiviral response	23
has an essential function	23
an essential function in	23
signal transducer and activator	23
to the activation of	23
the rna helicase rig	23
induced innate antiviral responses	22
of nucleic acid immunity	22
the influenza a virus	22
laboratory of genetics and	22
of type i and	22
the host innate immune	22
the most informative words	22
of genetics and physiology	22
e ubiquitin ligase is	21
and the activation of	21
the crystal structure of	21
antiviral innate immune responses	21
has been reported to	21
ligase is essential for	21
type i ifns and	21
type i interferon response	21
been found to be	21
has been shown that	21
has also been shown	21
recognition of rna viruses	21
type i ifn and	21
structural basis for the	21
ubiquitin ligase is essential	21
the expression of type	21
the ligand for rig	20
a positive regulator of	20
the formation of the	20
i and mda signaling	20
and is targeted by	20
the recognition of rna	20
differential roles of mda	20
a critical role in	20
helicases in the recognition	20
response to viral infection	20
type i ifn responses	20
i helicases in the	20
the ubiquitin ligase trim	20
roles of mda and	20
i ifn production in	20
essential function in double	19
triphosphate rna is the	19
in vitro and in	19
rna is the ligand	19
caspase activation and recruitment	19
targeted by hepatitis c	19
is the ligand for	19
innate immune responses to	19
have been reported to	19
of ns and ns	19
cells were infected with	19
has been found to	19
ebola virus vp protein	19
dexd h box rna	19
to type i ifn	19
o methylation of the	18
for the induction of	18
studies have shown that	18
in plasmacytoid dendritic cells	18
of innate immune responses	18
the interferon antiviral response	18
antiviral responses to single	18
space of meaning for	18
protein that activates nf	18
is one of the	18
is involved in the	18
a mitochondrial antiviral signaling	18
hepatitis c virus replication	18
and characterization of mavs	18
mediated antiviral responses to	18
signaling protein that activates	18
to the category c	18
to be involved in	18
antiviral signaling protein that	18
play an important role	18
it is important to	18
in the formation of	18
in the production of	18
to evade recognition by	18
vitro and in vivo	17
antiviral signal activation by	17
evade recognition by the	17
of the viral genome	17
for the development of	17
plays a role in	17
negative regulation of the	17
innate immune response in	17
of meaning for scientific	17
recognition by the host	17
the hepatitis c virus	17
these results indicate that	17
crystal structure of the	17
in the innate immune	17
a role in the	17
plays an important role	17
the ns protein of	17
activation of the ifn	17
is an adaptor protein	17
ubiquitin ligase trim to	17
rna recognition by rig	17
meaning for scientific texts	17
host innate immune response	17
innate and adaptive immunity	17
informational space of meaning	17
activation of type i	16
an adaptor protein in	16
host viral rna sensor	16
cardif is an adaptor	16
c virus ns a	16
by the host viral	16
trim to evade recognition	16
adaptor protein in the	16
an adaptor triggering rig	16
pathway and is targeted	16
ns targets the ubiquitin	16
targets the ubiquitin ligase	16
meaning of a word	16
the ubiquitination of rig	16
are involved in the	16
of the viral mrna	16
the activation of rig	16
can be found in	16
recognition of viral rna	16
protein in the rig	16
the viral mrna cap	16
the host viral rna	16
activation of innate immune	16
antiviral pathway and is	16
i antiviral pathway and	16
in response to viral	16
a virus ns targets	16
innate immune receptor rig	16
is targeted by hepatitis	16
methylation of the viral	16
the distinction of self	16
ligase trim to evade	16
virus ns targets the	16
degradation by the proteasome	16
linked ubiquitination of rig	16
innate and adaptive immune	15
it has been reported	15
i ifn production and	15
antiviral response by targeting	15
type i interferon and	15
on the cell surface	15
the inhibitory effect of	15
is essential for the	15
induce the expression of	15
suppressor of cytokine signaling	15
a type i ifn	15
i and iii ifns	15
first line of defense	15
finger e ubiquitin ligase	15
influenza a virus infection	15
the antiviral activity of	15
in the pathogenesis of	15
spry domain of trim	14
mediated antiviral signaling by	14
of the rna sensors	14
activation and recruitment domains	14
to the production of	14
an e ubiquitin ligase	14
the early phase of	14
has been reported that	14
polymorphisms of genes encoding	14
the rna sensors rig	14
interaction between trim and	14
as a negative regulator	14
important role in the	14
positive regulator of rig	14
the expression of the	14
retinoic acid inducible gene	14
also been found to	14
induce type i ifn	14
ns and or ns	14
the host immune response	14
be involved in the	14
one of the most	14
at the end of	14
of severe acute respiratory	14
respiratory syncytial virus nonstructural	14
the meaning of a	14
of the transcription factors	13
helicase requires short blunt	13
the host antiviral response	13
t cells were seeded	13
type i interferon pathway	13
translocate to the nucleus	13
the expression levels of	13
induces the expression of	13
the induction of an	13
regulation of innate antiviral	13
the innate immune sensor	13
contained in panhandle of	13
innate antiviral defenses through	13
line of defense against	13
repressor domain in rig	13
through a shared repressor	13
antiviral defenses through a	13
virus kato et al	13
of innate antiviral defenses	13
cells were seeded in	13
the first line of	13
herpes simplex virus type	13
these data suggest that	13
can be activated by	13
be explained by the	13
a shared repressor domain	13
and laboratory of genetics	13
by the influenza a	13
of tlr and tlr	13
a crucial role in	13
of viral nucleic acids	13
is a positive regulator	13
rna as contained in	13
the rna sensor mda	13
defenses through a shared	13
the interaction between rig	13
presence or absence of	13
production in response to	13
as contained in panhandle	13
pattern recognition receptors and	13
of traf and traf	13
i helicase requires short	13
tlr and tlr are	13
the cells were lysed	13
the spry domain of	13
shared repressor domain in	13
the formation of a	13
recognition by the innate	13
ifn production and signaling	13
eukaryotic translation initiation factor	12
shared and unique functions	12
for the distinction of	12
role of unanchored polyubiquitin	12
respiratory syncytial virus infection	12
it was shown that	12
the antiviral immune response	12
functions of the dexd	12
and lgp in antiviral	12
type i interferons and	12
tumor necrosis factor receptor	12
the activation of nf	12
polyubiquitin chains in innate	12
these results suggest that	12
and activation of nf	12
activation of irf and	12
most informative words in	12
the monolayer cells were	12
in myeloid dendritic cells	12
and unique functions of	12
it is likely that	12
of herpes simplex virus	12
an adapter protein required	12
i pathway reveals a	12
adapter protein required for	12
i ifn responses to	12
of unanchored polyubiquitin chains	12
unique functions of the	12
visa is an adapter	12
c k w j	12
at the level of	12
in panhandle of negative	12
in the cytosol of	12
by interfering with trim	12
negative feedback regulation of	12
plays a critical role	12
and induces type i	12
is dependent on the	12
induced type i ifn	12
of the immune response	12
is an adapter protein	12
and the monolayer cells	12
of the dexd h	12
host innate immune responses	12
protein required for virus	12
basis for the activation	12
respiratory syndrome coronavirus papain	12
of innate immune response	12
unanchored polyubiquitin chains in	12
c virus rna replication	12
chains in innate immunity	12
is required for the	12
is critical for the	12
reconstitution of the rig	12
rna and activation of	12
cys and his residues	12
interferon regulatory factor activation	12
lectin receptors and rig	12
lgp in antiviral innate	12
by ifit family members	12
and nuclear translocation of	12
of porcine epidemic diarrhea	12
shown to interact with	12
the end of the	12
a wide range of	12
type lectin receptors and	12
i and mda have	12
the mechanisms by which	12
the activation of innate	12
type i interferon in	12
i by viral rna	12
reveals a signaling role	11
the interferon regulatory factor	11
and cellular antiviral response	11
is mediated by the	11
in the level of	11
plays a crucial role	11
mediated type i ifn	11
propagate antiviral innate immune	11
ns protein of influenza	11
dependent on the rna	11
as found in arenavirus	11
rna viruses such as	11
and the induction of	11
the presence or absence	11
dependent innate immune responses	11
like aggregates to activate	11
the iav control group	11
basis for dsrna recognition	11
type i and type	11
the adaptor protein mita	11
aggregates to activate and	11
to be essential for	11
to evade innate immunity	11
at the same time	11
the adaptive immune response	11
the activation of irf	11
the role of the	11
on the expression of	11
to be activated by	11
the mechanism by which	11
in hepatitis c virus	11
and type i ifn	11
formation of stress granules	11
to the nucleus and	11
to the expression of	11
pathway reveals a signaling	11
to the induction of	11
with the exception of	11
the level of isg	11
structural basis for dsrna	11
of the viral rna	11
that ns and ns	11
been shown to induce	11
inhibits type i ifn	11
viral mrna cap evades	11
been shown to inhibit	11
restriction by ifit family	11
respiratory syncytial virus ns	11
innate immune signaling pathways	11
in innate immune signaling	11
the expression of ifn	11
of the signaling cascade	11
of innate immune signaling	11
signaling role of unanchored	11
ribonucleic acids by retinoic	11
and propagate antiviral innate	11
linked polyubiquitination of the	11
evades host restriction by	11
type i ifns in	11
mrna cap evades host	11
in the expression of	11
nuclear translocation of irf	11
of the immune system	11
in the cytoplasm of	11
cap evades host restriction	11
i and melanoma differentiation	11
innate immune responses in	11
i and iii ifn	11
play important roles in	11
cells infected with the	11
to activate and propagate	11
mavs forms functional prion	11
has been demonstrated to	11
activate and propagate antiviral	11
early phase of viral	11
distinction of self and	11
i and mda are	11
stranded rna as contained	11
of rlr signaling pathway	11
and adaptive immune responses	11
a signaling role of	11
host restriction by ifit	11
lgp is a positive	11
during the early phase	11
requires short blunt double	11
type i ifn in	11
ubiquitination and degradation of	11
myeloid differentiation primary response	11
important to note that	11
the text belongs to	11
in the control of	11
versus the iav control	11
of self and non	11
of a word is	11
have been identified as	10
termini as a strategy	10
on the rna sensor	10
detects cytosolic dna and	10
sensing of viral replication	10
is important to note	10
protein of influenza a	10
of isg and its	10
phase of viral infection	10
of genes encoding c	10
with clustalw implemented in	10
has been identified as	10
a ring finger protein	10
were collected from ensembl	10
molecular signature for the	10
g allele of rs	10
type i ifn expression	10
iii detects cytosolic dna	10
inhibits the activation of	10
provides a molecular signature	10
of a variety of	10
interferons through the rig	10
clustalw implemented in bioedit	10
i interferon signaling by	10
essential role of mda	10
was found to be	10
dna and induces type	10
during influenza virus infection	10
innate antiviral response by	10
and activation of antiviral	10
words in each category	10
which is required for	10
aligned with clustalw implemented	10
used by viruses to	10
as a strategy of	10
t cells were transfected	10
from observing the word	10
respiratory syndrome coronavirus nsp	10
collected from ensembl and	10
is the probability that	10
has not yet been	10
type i interferons through	10
specific recognition of single	10
of innate immune pattern	10
to induce type i	10
cytosolic dna and induces	10
it remains to be	10
a cytosolic dna sensor	10
of antiviral immune responses	10
hepatitis c virus nonstructural	10
pathogen recognition and innate	10
regulate the expression of	10
i interferons through the	10
rna recognition and activation	10
it is interesting to	10
used in this study	10
at an moi of	10
which is essential for	10
is also involved in	10
the ability of the	10
ifn responses to polyriboinosinic	10
is not required for	10
innate immune signaling by	10
of porcine reproductive and	10
of viral rna by	10
has been implicated in	10
unusual viral rna species	10
emcv and jev infection	10
signature for the distinction	10
mrna dependent on the	10
h box rna helicase	10
acid and encephalomyocarditis picornavirus	10
the unfolded protein response	10
to hepatitis c virus	10
as shown in figure	10
ensembl and ncbi databases	10
structural insights into rna	10
polyubiquitination of the rig	10
i ifn production by	10
in influenza a virus	10
in the inhibition of	10
the ebola virus vp	10
drv or b c	10
signal activation by mda	10
respiratory syndrome coronavirus m	10
word w j in	10
the regulation of the	10
i ifn response in	10
is responsible for the	10
in the presence or	10
is associated with the	10
is a negative regulator	10
from ensembl and ncbi	10
of irf and irf	10
rna viruses to avoid	10
polymerase iii detects cytosolic	10
j and m j	10
s j and m	10
it was found that	10
rna polymerase iii detects	10
insights into rna recognition	10
and antiviral signal activation	10
syndrome coronavirus m protein	10
a molecular signature for	10
a large number of	10
recognition and innate immunity	10
interaction between ns and	10
the activity of the	10
an essential component of	10
induces type i interferons	10
viruses to avoid rig	10
polyribocytidylic acid and encephalomyocarditis	10
to activate antiviral signaling	10
of emcv and jev	9
induce the formation of	9
i to promote interferon	9
helicase and activation of	9
have been found to	9
i detects viral genomic	9
the ubiquitin ligase rnf	9
can be considered as	9
acids by retinoic acid	9
and aligned with clustalw	9
production by interfering with	9
reference sequence of human	9
role of tlr in	9
triphosphate sensor of rig	9
regulation of the rig	9
for type i ifn	9
induced oligomerization of the	9
with drv or b	9
will be discussed in	9
ns a cleaves mitochondrial	9
human immunodeficiency virus type	9
c virus core protein	9
conjugation to target proteins	9
i helicase and activation	9
interesting to note that	9
detects viral genomic rna	9
deletion in the alignment	9
is interesting to note	9
proteins have been shown	9
is a cytosolic dna	9
a gap or deletion	9
the expression of rig	9
cleaves mitochondrial antiviral signaling	9
or deletion in the	9
of pattern recognition receptors	9
stimulator of ifn genes	9
it has been demonstrated	9
as well as in	9
the authors declare no	9
the host immune system	9
as the reference sequence	9
the interaction between trim	9
virus protease ns a	9
were immunoprecipitated with anti	9
regulation of type i	9
sensing mechanism of rig	9
by plasmacytoid dendritic cells	9
an antiviral state in	9
these findings suggest that	9
it has been proposed	9
a cleaves mitochondrial antiviral	9
i interferon signaling pathway	9
a strategy of negative	9
induced activation of nf	9
the word in the	9
to rna virus infection	9
may be due to	9
inhibits the type i	9
was shown to be	9
by the fact that	9
the immune response to	9
cells were treated with	9
antiviral signaling protein off	9
induction of an rna	9
innate immunity induced by	9
of the rlr pathway	9
in contrast to the	9
stranded rna and activation	9
through the induction of	9
into rna recognition by	9
regulation of gene expression	9
involved in the recognition	9
positive and negative regulation	9
is represented by a	9
by type i ifns	9
the middle east respiratory	9
the innate immune receptor	9
i ifn induction by	9
rna interference in mammalian	9
adenosine deaminase acting on	9
of the innate antiviral	9
protease ns a cleaves	9
signaling protein off the	9
as shown in fig	9
rna viruses in innate	9
it has also been	9
and activation of the	9
the structure of the	9
peripheral blood mononuclear cells	9
i interferon induction and	9
activation of the innate	9
production induced by rig	9
in the form of	9
the antiviral effect of	9
stranded ribonucleic acids by	9
viral genomic rna during	9
induction during the early	9
of irf and nf	9
of rna recognition and	9
off the mitochondria to	9
c virus protease ns	9
hepatitis c virus protease	9
strand rna viruses to	9
strand rna virus infection	9
cells were incubated with	9
the card domains of	9
dependent innate immune response	9
been shown to play	9
of dexd h box	9
and negative regulation of	9
activation of antiviral immune	9
filaments in an atp	9
regulatory factor activation by	9
structure and function of	9
to type i ifns	9
signaling by rna viruses	9
the transcription factors irf	9
protein off the mitochondria	9
tlr is expressed in	9
role of trims in	9
regulatory domain is the	9
activation of interferon regulatory	9
it is noteworthy that	9
for the treatment of	9
by the ubiquitin ligase	9
gap or deletion in	9
species were collected from	9
rna in the cytosol	9
recognition and activation by	9
mitochondria to evade innate	9
mda signaling by rna	9
oligomerization of the rna	9
modulates type i interferon	9
of middle east respiratory	9
stimulator of interferon genes	9
inflammatory cytokines and chemokines	9
single nucleotide polymorphisms of	9
is an endoplasmic reticulum	9
proteins ns and ns	9
h box rna helicases	9
to the nucleus to	9
new insights into the	9
an innate immune sensor	9
of innate and adaptive	9
interferon antiviral response through	9
the innate immune responses	9
hepatitis c virus core	9
e ubiquitin ligase and	9
i and mda in	9
interference in mammalian cells	9
for the detection of	9
domain is the rna	9
activation of protein kinase	9
an rna polymerase iii	9
mammalian species were collected	9
in the present study	9
by rna viruses in	9
the mitochondria to evade	9
dependent sensing of poly	9
by acting as a	9
the reference sequence of	9
or infected with svv	9
i and mda activates	9
cellular antiviral response by	9
genomic rna during negative	9
of the ifn response	9
recognition of hepatitis c	9
methylation provides a molecular	9
the context of viral	9
of an rna polymerase	9
and mda activates antiviral	9
the course of infection	9
and mda signaling by	9
response to virus infection	9
viruses in innate immunity	9
been implicated in the	9
innate antiviral responses by	9
the rna helicase lgp	9
essential component of the	9
play a critical role	9
an essential role in	8
and the formation of	8
stranded rna via toll	8
virus c protease cleaves	8
viral replication by retinoic	8
as part of the	8
structures generated during virus	8
structural basis of rna	8
required for virus replication	8
to be responsible for	8
i interferon pathway by	8
the effect of ns	8
i repressor domain in	8
a single amino acid	8
i ubiquitination and ifn	8
in response to cytoplasmic	8
the results showed that	8
i signaling by the	8
like protease inhibits the	8
sting is an endoplasmic	8
access article distributed under	8
the absence of the	8
innate immunity by targeting	8
ifn induction by the	8
and severe acute respiratory	8
activation in response to	8
have been identified in	8
the role of tlr	8
translocated into the nucleus	8
of cd t cells	8
in the supernatants of	8
a broad range of	8
like receptor signaling pathway	8
family of transcription factors	8
of the ns protein	8
as well as viral	8
the nuclear translocation of	8
the activation of transcription	8
the authors declare that	8
i recognition of hepatitis	8
card and rd regions	8
an isg e ligase	8
and innate antiviral immunity	8
induces type i interferon	8
increase in the level	8
cell lysates were immunoprecipitated	8
e ligase activity of	8
a distinct role of	8
are responsible for the	8
adaptor that facilitates innate	8
i in antiviral response	8
with the supernatants from	8
triggered type i ifn	8
activation by innate immune	8
an increase in the	8
type i interferon responses	8
induce the production of	8
rna structures generated during	8
to play a role	8
type i ifn treatment	8
of words in the	8
pattern recognition receptors in	8
shown to bind to	8
these results demonstrate that	8
of the creative commons	8
dexd h box helicase	8
to the inhibition of	8
distributed under the terms	8
rna helicase lgp inhibits	8
to the identification of	8
classical swine fever virus	8
the expression of isgs	8
have also been shown	8
the card domain of	8
mda activates antiviral innate	8
domain in human antiviral	8
of antiviral innate immunity	8
hepatitis c virus and	8
the activation of ifn	8
and activation by innate	8
for the inhibition of	8
of cytokines and chemokines	8
interferon regulatory factor family	8
c virus nonstructural protein	8
rnas in mammalian cells	8
by innate immune receptor	8
self mrna dependent on	8
have also been found	8
of viral replication by	8
signaling by the ubiquitin	8
and the production of	8
macrophages and dendritic cells	8
no conflict of interest	8
are essential for the	8
order rna structures generated	8
as a viral deubiquitinase	8
mediated antiviral innate immunity	8
replication by retinoic acid	8
in the meaning space	8
innate immune response and	8
inhibition of type i	8
the function of the	8
to induce the expression	8
endoplasmic reticulum adaptor that	8
of respiratory syncytial virus	8
category c k from	8
facilitates innate immune signalling	8
and the innate immune	8
has been demonstrated that	8
in the immune response	8
mediated recognition of rna	8
stranded rna recognition by	8
it was reported that	8
the role of rnase	8
is required for virus	8
in the release of	8
studies have demonstrated that	8
phosphorylation and activation of	8
that facilitates innate immune	8
the cells were infected	8
antiviral innate immunity the	8
the role of isg	8
the interaction of rig	8
by a vector of	8
type i interferon by	8
lysates were immunoprecipitated with	8
card domains of rig	8
that are involved in	8
article distributed under the	8
type i ifn receptor	8
human antiviral innate immune	8
rd regions of zbrig	8
during hepatitis c virus	8
activates antiviral innate immune	8
the n protein of	8
feedback regulation of rig	8
the creative commons attribution	8
virus nonstructural protein a	8
dependent type i ifn	8
of the severe acute	8
in the nucleus and	8
and the role of	8
regulation of interferon regulatory	8
sendai virus c protein	8
in the current study	8
to a lesser extent	8
beta induction during the	8
protein inhibits type i	8
this work was supported	8
coronavirus open reading frame	8
we found that the	8
deubiquitinating and interferon antagonism	8
infected with drv or	8
resulting in the activation	8
the structural basis of	8
variant allele of rs	8
reticulum adaptor that facilitates	8
in the infected cells	8
the majority of the	8
the transcription factor irf	8
in human antiviral innate	8
melanoma differentiation associated gene	8
immune responses to rna	8
and the helicase domain	8
our understanding of the	8
basis of rna recognition	8
an endoplasmic reticulum adaptor	8
host type i interferon	8
represented by a vector	8
belong to the category	8
innate immune system is	8
analyzed by western blotting	8
on the surface of	8
word is represented by	8
a broad spectrum of	8
as well as a	8
specific involvement of rig	8
generated during virus infection	8
immune signaling by rig	8
acting as a viral	8
syncytial virus ns protein	8
repressor domain in human	8
to west nile virus	8
has also been found	8
rift valley fever virus	8
the expression of trim	8
by west nile virus	7
the formation of traf	7
plays an essential role	7
the mavs signaling pathway	7
influenza virus ns protein	7
with the n protein	7
tumor necrosis factor alpha	7
in the innate antiviral	7
a diverse range of	7
herpes simplex virus ubiquitin	7
expression of hundreds of	7
induction of beta interferon	7
absence of any commercial	7
in different cell types	7
the innate immune signaling	7
a decrease in the	7
viruses have been shown	7
the phosphorylation of stat	7
a novel e ubiquitin	7
regulates the type i	7
membrane association and innate	7
to interact with mavs	7
the c terminus of	7
which results in the	7
immunity induced by composition	7
the importance of the	7
the viral rna sensor	7
financial relationships that could	7
independent sensing of viral	7
to the formation of	7
inflammation and ali bx	7
or financial relationships that	7
syncytial virus nonstructural protein	7
the inhibition of rig	7
the mammalian innate immune	7
of the irf signaling	7
raises the question of	7
to interact with the	7
of the protein kinase	7
nucleocapsid inhibits type i	7
interferon production by interfering	7
like receptors and their	7
of rnase l in	7
which is important for	7
to irf transcription factor	7
the jak stat pathway	7
any commercial or financial	7
antiviral response by the	7
the mechanism through which	7
dendritic cells through tlr	7
the prrsv n protein	7
for the recognition of	7
the formation of sgs	7
to the nucleus where	7
from the word w	7
dna and rna sensing	7
a major role in	7
respiratory syndrome coronavirus nucleocapsid	7
amounts of type i	7
the central nervous system	7
host innate antiviral response	7
against hepatitis c virus	7
that could be construed	7
pathway by acting as	7
protein with tetratricopeptide repeats	7
the nature of the	7
and hepatitis c virus	7
evasion of intracellular dna	7
a pivotal role in	7
isg and its conjugation	7
interferon induction and cellular	7
competent filaments in an	7
mediates membrane association and	7
on the presence of	7
which in turn activates	7
authors declare that the	7
a dexd h box	7
activates the nlrp inflammasome	7
and ali bx zhou	7
antiviral immunity via rig	7
infected or infected with	7
in the development of	7
in a variety of	7
the induction of isg	7
by the activation of	7
stranded rna and inhibits	7
be construed as a	7
i translocon that mediates	7
helicase lgp inhibits tlr	7
dna and rna viruses	7
vp protein binds double	7
inhibition of interferon regulatory	7
mediated ubiquitination of rig	7
of any commercial or	7
declare that the research	7
viral rna detection by	7
leads to the activation	7
one of the first	7
between ns and trim	7
virus ns a protease	7
the three rlr genes	7
arms race between host	7
work was supported by	7
e ubiquitin ligase trim	7
positive strand rna viruses	7
induced inflammation and ali	7
in type i interferon	7
potential conflict of interest	7
of protein synthesis by	7
in the degradation of	7
the host response to	7
our results showed that	7
and is required for	7
that mediates membrane association	7
can be explained by	7
cells in response to	7
the recruitment of the	7
to be further investigated	7
mediated degradation of irf	7
in our understanding of	7
was conducted in the	7
an essential role for	7
mediated cleavage of the	7
to be required for	7
receptors to irf transcription	7
the research was conducted	7
the absence of any	7
class ii cytokine receptor	7
rnas with an overhanging	7
strand rna viruses and	7
of protein kinase r	7
permissiveness to hepatitis c	7
commercial or financial relationships	7
a variant allele of	7
the mitochondrial antiviral signaling	7
on type i ifn	7
induction by the influenza	7
activation of transcription factors	7
were transfected with flag	7
translocon that mediates membrane	7
found to be the	7
the v proteins of	7
of japanese encephalitis virus	7
isg and its conjugates	7
ubiquitin ligase riplet is	7
intracellular dna and rna	7
induced protein with tetratricopeptide	7
the protein kinase pkr	7
that the spry domain	7
the irf signaling pathway	7
ubiquitination and ifn induction	7
relationships that could be	7
an overview of the	7
in the endosomal compartment	7
responses to rna virus	7
the ubiquitin ligase riplet	7
of intracellular dna and	7
the physiological significance of	7
activation of the type	7
syncytial virus nonstructural proteins	7
has been proposed that	7
viral evasion of intracellular	7
found to interact with	7
induction and cellular antiviral	7
found in arenavirus genomes	7
also involved in the	7
association and innate antiviral	7
viral innate immune evasion	7
interferon production induced by	7
innate immune responses and	7
h at room temperature	7
irf transcription factor activation	7
will be necessary to	7
signal activation by rig	7
that the research was	7
based model of rig	7
by the presence of	7
activation of mda requires	7
which is recognized by	7
is also able to	7
have yet to be	7
translocation to the nucleus	7
the antiviral action of	7
the viral life cycle	7
ligase riplet is essential	7
dependent recognition of double	7
a type i interferon	7
results in the activation	7
adaptor protein mita links	7
syndrome coronavirus nucleocapsid inhibits	7
in the antiviral response	7
nonstructural proteins ns and	7
recognition of rna bearing	7
by the induction of	7
innate immune recognition of	7
as a potential conflict	7
in the suppression of	7
h n influenza a	7
at the interface of	7
texts containing the word	7
could be construed as	7
in line with the	7
activation of pkr by	7
is targeted by the	7
containing adaptor inducing ifn	7
conducted in the absence	7
coronavirus nucleocapsid inhibits type	7
during an rsv infection	7
and ifn induction by	7
by interacting with the	7
of mda requires higher	7
deaminase acting on rna	7
between trim and rig	7
w j in the	7
differentiation primary response gene	7
been shown to interact	7
a conformational change that	7
activation of the rig	7
negative regulator of rig	7
word in the text	7
shown to play a	7
construed as a potential	7
in intestinal epithelial cells	7
were found to be	7
at the molecular level	7
beta interferon production by	7
west nile virus infection	7
research was conducted in	7
patients with chronic hepatitis	7
phosphorylation and nuclear translocation	7
the role of trim	7
was identified as a	7
with severe acute respiratory	7
immune cells such as	7
interferon pathway by acting	7
level of isg conjugates	7
the induction of innate	7
riplet is essential for	7
is an innate immune	7
in vitro transcribed rna	7
mediated innate immune signaling	7
the mitochondrial targeting chaperone	7
and rd regions of	7
virus vp protein binds	7
transfected with the indicated	7
ns a and ns	7
impeding the formation of	7
a potential conflict of	7
specific inhibition of rig	7
of protein kinase pkr	7
to be the case	7
the expression of proinflammatory	7
polyubiquitination of the cards	7
with the indicated antibodies	7
the synthesis of unanchored	7
receptors in innate immunity	7
words in two lists	6
been shown to bind	6
previous studies have shown	6
incoming rna virus nucleocapsids	6
mda detects the double	6
the meaning of words	6
suppression of type i	6
genes involved in the	6
activation and recruitment domain	6
the expression level of	6
the interferon response to	6
cd t cells and	6
innate immune sensor retinoic	6
plasmacytoid dendritic cells through	6
the activation of type	6
viral infection switches non	6
expression in response to	6
interfering rna in plasmacytoid	6
replication through a cellular	6
short viral rna molecules	6
is a novel e	6
essential role in the	6
triggering the interferon antiviral	6
c virus replication by	6
discriminating between self and	6
defense and permissiveness to	6
other members of the	6
rna replicative form in	6
belongs to the category	6
it is clear that	6
and tbk are essential	6
interferon antiviral response by	6
response through an ikk	6
stranded rnas in mammalian	6
of the nlrp inflammasome	6
is associated with a	6
induction of the ifn	6
i for short viral	6
cleaved during picornavirus infection	6
trim modulates type i	6
were infected with the	6
aim activates the inflammasome	6
and interferon antagonism activities	6
that the n protein	6
of the adaptor protein	6
innate immune sensing of	6
response to type i	6
basis for discriminating between	6
to determine whether the	6
is produced by positive	6
inhibiting the activation of	6
trigger the production of	6
an antiviral protein that	6
and the release of	6
results indicate that the	6
innate immune response is	6
i as well as	6
the mitochondrial outer membrane	6
rna molecules in infected	6
tbk are essential components	6
distinct role of riplet	6
virus nucleocapsids containing a	6
cells via the tlr	6
interferon signaling pathway through	6
c virus identification and	6
in detectable amounts by	6
pi k akt pathway	6
integration by the innate	6
leading to the activation	6
is essential for innate	6
type i interferon antiviral	6
receptors and cancer risk	6
intracellular antiviral defense and	6
induced proteins with tetratricopeptide	6
to the site of	6
responses by means of	6
herc via isg modification	6
into the nucleus and	6
direct interaction of irf	6
perception and integration by	6
lgp manifests disparate antiviral	6
remains to be seen	6
it is not clear	6
interferon antagonism activities of	6
same nucleotide as the	6
regulates type i interferon	6
functions as a negative	6
response by targeting rig	6
the positive and negative	6
potent induction of ifn	6
the activation of tlr	6
by herc via isg	6
loss of dexd h	6
translocates into the nucleus	6
antibody and analyzed by	6
infected with the indicated	6
stranded rna replicative form	6
six mammalian species were	6
to an increase in	6
there is increasing evidence	6
trim ringfinger e ubiquitin	6
viruses and dna viruses	6
but not in detectable	6
that the text belongs	6
trim to suppress rig	6
mhc class i molecules	6
and the expression of	6
plasmacytoid dendritic cells into	6
ubiquitin ligase and stimulator	6
like receptors and nod	6
unmethylated cpg motifs in	6
inhibition of protein synthesis	6
a direct interaction of	6
a and ns b	6
has yet to be	6
into the cytosol of	6
inhibits host gene expression	6
activities of coronavirus papain	6
of viral replication and	6
c k from the	6
observing the word w	6
structural and functional insights	6
activation by herc via	6
a model in which	6
bodies and stress granules	6
signaling pathway through interaction	6
virus ns a protein	6
of irf with myd	6
virus identification and characterization	6
role of rnase l	6
a great number of	6
and stress granule formation	6
to inhibit type i	6
of the mammalian innate	6
i structural basis for	6
their interaction with the	6
distribution or reproduction is	6
and analyzed by western	6
the phosphorylation of irf	6
sitosterol on the expression	6
also been described to	6
i and type iii	6
functional consequences at the	6
antagonize type i ifn	6
mechanism of signal perception	6
inhibits hepatitis c virus	6
infected cells revealed by	6
domain and a c	6
like receptors and cancer	6
helicase lgp manifests disparate	6
to influenza a virus	6
synthesis of unanchored k	6
detection of viral rna	6
irf with myd and	6
i ifn response to	6
consequences at the molecular	6
by the e ligase	6
the e ligase activity	6
are a family of	6
monolayer cells were transfected	6
inhibition of ifn production	6
involves a direct interaction	6
activate antiviral signaling via	6
inhibitor of nuclear factor	6
components of the irf	6
into high interferon producers	6
antiviral responses by means	6
by japanese encephalitis virus	6
strand rna virus replication	6
the cytoplasm of infected	6
short interfering rna in	6
the role of pattern	6
response to poly i	6
k from the word	6
by in vitro transcription	6
via the tlr myd	6
novel e ubiquitin ligase	6
reproduction is permitted which	6
been identified as a	6
represents the same nucleotide	6
the case of the	6
the eukaryotic translation initiation	6
is permitted which does	6
we will focus on	6
have been demonstrated to	6
is a member of	6
as a positive regulator	6
to antagonize ifn induction	6
proteins with tetratricopeptide repeats	6
by type i ifn	6
of viral nucleic acid	6
antiviral response through an	6
inhibits alpha beta interferon	6
antagonism activities of coronavirus	6
of the transcription factor	6
the interaction of the	6
cd t cells in	6
and permissiveness to hepatitis	6
rna and inhibits alpha	6
the covalent attachment of	6
dimerization and nuclear translocation	6
acid inducible gene i	6
innate immune responses against	6
receptors involves a direct	6
text belongs to the	6
is an antiviral protein	6
in turn leads to	6
the recognition of viral	6
of the category c	6
innate antiviral immune responses	6
viral compounds activate immune	6
represents a gap or	6
triphosphate rna requires base	6
inhibits the expression of	6
dendritic cells into high	6
translocate into the nucleus	6
rna helicase lgp manifests	6
category c k and	6
virus rna replication through	6
m a and m	6
by human ifit proteins	6
and function of the	6
rna viruses and dna	6
on the basis of	6
nuclear translocation of stat	6
authors declare no conflict	6
of an antiviral state	6
the role of trims	6
are listed in table	6
structural basis for viral	6
of semliki forest virus	6
the nucleocapsid protein of	6
antiviral defense and permissiveness	6
leading to the expression	6
structures to activate antiviral	6
spry domain of zbtrim	6
the meaning space is	6
the interaction between ns	6
pp a and pp	6
induced by type i	6
of the lassa virus	6
the expression of hundreds	6
as a vector of	6
between self and non	6
n protein of prrsv	6
between self and nonself	6
and dna viruses but	6
of the host cell	6
expression level of prrs	6
ifit is an antiviral	6
by means of tlr	6
rna replication through a	6
little is known about	6
is illustrated by the	6
with the indicated plasmids	6
rna and dna viruses	6
the arms race between	6
be the case for	6
ifn induction by sh	6
signal perception and integration	6
positive regulation of interferon	6
it has recently been	6
in the ifn response	6
in a mouse model	6
cytoplasm of infected cells	6
linked ubiquitination of traf	6
triphosphorylated genome activate rig	6
i and mda activation	6
for h at room	6
rna recognition by human	6
reul is a novel	6
ringfinger e ubiquitin ligase	6
by short interfering rna	6
the formation of stress	6
orf b and orf	6
and k of the	6
viruses but not in	6
molecular mechanism of signal	6
activation of the antiviral	6
does not comply with	6
box rna helicase lgp	6
in infected cells revealed	6
sars coronavirus nsp protein	6
functions of ns and	6
presented as the mean	6
i and iii interferon	6
viral rna molecules in	6
into the nucleus to	6
antiviral protein that recognizes	6
does not belong to	6
immune cells via the	6
protease inhibits the type	6
in response to poly	6
a cellular rna helicase	6
in a manner that	6
is inhibited by the	6
viral evasion and subversion	6
that is dependent on	6
or reproduction is permitted	6
in chronic hepatitis c	6
antiviral signaling via rig	6
may play a role	6
with myd and traf	6
alpha beta interferon production	6
cells into high interferon	6
and degradation of irf	6
host innate immune system	6
mediated antiviral responses the	6
and integration by the	6
are known to be	6
a vector of rigs	6
to interfere with the	6
innate immune responses by	6
activates the inflammasome and	6
paired structures to activate	6
of the influenza a	6
or b c at	6
detectable amounts by negative	6
ifit impairs translation of	6
ifn production in the	6
for discriminating between self	6
a structural basis for	6
this is illustrated by	6
effector functions of ns	6
the number of texts	6
which does not comply	6
innate immune sensor for	6
cells infected with iav	6
the signaling adaptor mavs	6
involved in the regulation	6
through a cellular rna	6
ligase and stimulator of	6
rna virus nucleocapsids containing	6
by respiratory syncytial virus	6
e ubiquitin ligase that	6
the same nucleotide as	6
structural insights into the	6
the interaction between the	6
i and mda by	6
sequestration by ifit impairs	6
recognition receptors and inflammation	6
terminal regulatory domain is	6
were mock infected or	6
by ifit impairs translation	6
was shown to bind	6
in the immune system	6
compounds activate immune cells	6
essential components of the	6
the antiviral function of	6
c protease cleaves nemo	6
declare no conflict of	6
by impeding the formation	6
interaction of irf with	6
i interferon antiviral response	6
manifests disparate antiviral responses	6
that are essential for	6
interferon production by targeting	6
cleaves nemo to impair	6
critical role in the	6
probability of observing the	6
interaction with the sting	6
each word is represented	6
self and nonself double	6
the respiratory syncytial virus	6
the suppression of rig	6
rna is produced by	6
not in detectable amounts	6
v proteins of paramyxoviruses	6
human peripheral blood mononuclear	6
response to west nile	6
and inhibits alpha beta	6
of signal perception and	6
factor activation by herc	6
of stat and stat	6
mediated innate immune response	6
led to the identification	6
regulating intracellular antiviral defense	6
rna in plasmacytoid dendritic	6
further studies will be	6
not belong to the	6
structural basis for discriminating	6
the transcription of ifn	6
for virus replication and	6
irf and or irf	6
production in infected cells	6
leading to activation of	6
not comply with these	6
beta interferon production induced	6
innate immune response against	6
in the respiratory tract	6
nucleotide as the reference	6
the life cycle of	6
influenza b virus infection	6
remains to be determined	6
pathway through interaction with	6
mock infected or infected	6
of the influenza virus	6
antiviral stress granule formation	6
are essential components of	6
is constitutively expressed in	6
of the role of	6
hepatitis c virus identification	6
of human respiratory syncytial	6
in response to the	6
alpha by short interfering	6
been reported to be	6
activate immune cells via	6
the transcription of type	6
and mapk signaling pathways	6
race between host innate	6
in response to infection	6
its conjugation to target	6
for short viral rna	6
protease cleaves nemo to	6
during the course of	6
in innate immune response	6
dna viruses but not	6
molecules in infected cells	6
can act as a	6
of nuclear factor kappa	6
i and antiviral signaling	6
permitted which does not	6
rna adenosine deaminase adar	6
innate antiviral immune response	6
e ubiquitin ligase rnf	6
in innate immune responses	6
through interaction with the	6
of tumor necrosis factor	6
evasion and subversion of	6
recognition by human ifit	6
negatively regulates the type	6
of acute promyelocytic leukemia	6
comply with these terms	6
recognition receptors in innate	6
for hepatitis c virus	5
as in the case	5
of human immunodeficiency virus	5
a major cause of	5
stress granule containing rig	5
can be used as	5
entry into the brain	5
is known about the	5
l in innate immunity	5
recognition of rna virus	5
be responsible for the	5
the chicken leukocyte receptor	5
infection with live listeria	5
death in response to	5
as an isg e	5
sensing receptors to irf	5
mechanisms of innate immune	5
does not seem to	5
and the mavs traf	5
virus vp protein and	5
site model a and	5
shown in figure a	5
host gene expression by	5
both tlr and tlr	5
the fact that the	5
rna pattern recognition by	5
that binds to the	5
has recently been found	5
of paramyxoviruses bind the	5
diverse range of gene	5
i and iii interferons	5
provide an overview of	5
modulation of the cytoplasmic	5
both in vitro and	5
i ifn signaling by	5
may be responsible for	5
is a prerequisite for	5
listeria by sensing secreted	5
as an ifn antagonist	5
role of adaptor trif	5
protein plays a role	5
as a tumor suppressor	5
blocks the nuclear translocation	5
of isg conjugates in	5
the lc gabarap family	5
the ubiquitin modification system	5
by rnas with short	5
the importance of trim	5
mhc class i gene	5
evades the host immune	5
and oas rnase l	5
in the culture supernatants	5
downstream of tlr and	5
were transfected with the	5
are recognized by the	5
immune response to viruses	5
and mavs in infected	5
of human peripheral blood	5
messenger that activates sting	5
mechanisms of host restriction	5
the nucleus where they	5
release of infectious virus	5
in the list of	5
the supernatants from b	5
inhibition of the type	5
the induction of the	5
hek t cells grown	5
ubiquitination and deubiquitination are	5
trif in the myd	5
regulation of the innate	5
have also been reported	5
a protein covalently linked	5
to trigger ifn activation	5
linked to poliovirus genome	5
live listeria by sensing	5
to escape the host	5
trim in the regulation	5
the regulation of antiviral	5
the activation of tbk	5
rnas with short stem	5
of innate immunity by	5
immunity to virus infection	5
ligase activity of trim	5
allele of rs polymorphism	5
triggers the activation of	5
associated death domain protein	5
required for inhibition of	5
inhibits the induction of	5
the regulation of innate	5
is supported by the	5
the rna polymerase iii	5
with the indicated viruses	5
has also been reported	5
the nucleus to induce	5
inhibits beta interferon production	5
regulates the expression of	5
the effect of trim	5
by inducing degradation of	5
to a decrease in	5
for antiviral innate immunity	5
the large tegument protein	5
i signaling by facilitating	5
the meaning of the	5
activates the type i	5
viral rna by rig	5
is located on the	5
preventing the activation of	5
the assembly of the	5
i ifn response is	5
activation and evasion of	5
type i and ii	5
of ifn regulatory factor	5
covalently linked to poliovirus	5
ectopic expression of ns	5
yet to be determined	5
translocated to the nucleus	5
response by synthetic sirna	5
like receptors activate mavs	5
i is cleaved during	5
it remains unclear whether	5
network of innate immune	5
cascade that leads to	5
also known as ips	5
the virus life cycle	5
can be obtained from	5
role in innate immune	5
is an e ubiquitin	5
endonucleolytic cleavage of mrnas	5
immune sensor retinoic acid	5
linked cyclic dinucleotide second	5
the datamonkey web server	5
detection and innate immunity	5
is a common target	5
also been reported to	5
immune sensor lgp activates	5
in the category c	5
cytoplasmic viral rna sensor	5
mediated antiviral signal activation	5
involved in type i	5
to the dexd h	5
that svv c pro	5
and innate immune signaling	5
the top words in	5
rnas in the cytosol	5
transcription factors irf and	5
innate immunity the rna	5
dependent endonucleolytic cleavage of	5
inhibition of virus replication	5
mediated activation of irf	5
with the help of	5
the ubiquitin e ligase	5
pattern recognition by the	5
n protein inhibits the	5
i and pkr in	5
the loss of rig	5
recent studies suggest that	5
which will be discussed	5
translocates to the nucleus	5
an innate immune response	5
studies are required to	5
insights into the role	5
not recognized by rig	5
been identified and characterized	5
to poliovirus genome rna	5
sensor lgp activates antiviral	5
influenza a virus and	5
of innate immunity and	5
in response to rna	5
rna helicase domain and	5
article can be found	5
on mhc class i	5
text from the corpus	5
of self versus non	5
results in activation of	5
protein covalently linked to	5
of the adaptive immune	5
n influenza a virus	5
are more susceptible to	5
mediated antiviral signal transduction	5
by the ns protein	5
components of innate immune	5
second messenger that activates	5
cited due to space	5
signaling cascade that leads	5
dispensable for viral replication	5
has not been investigated	5
innate immune sensor of	5
resulting in the expression	5
to the recruitment of	5
cell death in response	5
and splice variant in	5
proteins of paramyxoviruses bind	5
by the interferon regulatory	5
the ctd of rig	5
in diverse cellular pathways	5
are presented in table	5
types i and iii	5
innate immune sensor lgp	5
codons under positive selection	5
studies are needed to	5
was thought to be	5
the top n words	5
member of the family	5
be discussed in detail	5
was identified as the	5
have also been described	5
mammalian innate immune response	5
novel antiviral factor promoting	5
and influenza a virus	5
plays a major role	5
in the antiviral immune	5
regulation of innate immunity	5
with the induction of	5
differentiation of acute promyelocytic	5
its degradation by the	5
have been linked to	5
i like receptors activate	5
linear ubiquitin assembly complex	5
the rlr signaling pathway	5
proteins vpr and vif	5
are effectors of the	5
rna recognition by the	5
like receptors involves a	5
to the presence of	5
the inflammasome and cell	5
treated with or without	5
antiviral factor promoting rig	5
stimulation of the mammalian	5
recognition of herpes simplex	5
replication and spread in	5
with the card domain	5
an activator of innate	5
of the rlr family	5
west nile virus ns	5
specific potent induction of	5
found to be essential	5
the degradation of the	5
in response to type	5
protein mita links virus	5
are present in the	5
in host defense against	5
by casein kinase ii	5
cells were mock infected	5
in antiviral innate immune	5
the importance of these	5
lgp activates antiviral signaling	5
i detects infection with	5
dinucleotide second messenger that	5
for its interaction with	5
mechanism of influenza a	5
measles virus c protein	5
and functional insights into	5
internal ribosome entry site	5
usp inhibits type i	5
and evolution of the	5
end of the viral	5
the deconjugases encoded by	5
the tir domain of	5
sensing of nucleic acids	5
activator of innate immune	5
the type i and	5
accordance with accepted academic	5
of signalling by toll	5
have been associated with	5
the west nile virus	5
of the most informative	5
terminal caspase activation and	5
ikkepsilon and tbk are	5
i and mda were	5
expression of proinflammatory cytokines	5
irf is constitutively expressed	5
adaptor trif in the	5
of the lc gabarap	5
type i interferon expression	5
and is involved in	5
measles virus v protein	5
card and splice variant	5
epidemic diarrhea virus c	5
induction cardif is an	5
of traf in the	5
and plasmacytoid dendritic cells	5
which in turn leads	5
independent mechanisms of host	5
signaling by regulating mda	5
supernatants from b c	5
which leads to the	5
to establish an antiviral	5
evidence of positive selection	5
to the cytoplasm and	5
cd t cell responses	5
rnase l in innate	5
trail and sfas ligand	5
of unusual viral rna	5
inflammasome and cell death	5
of mouse hepatitis virus	5
of a novel coronavirus	5
have the ability to	5
inducible nitric oxide synthase	5
the induction of cytokines	5
in two lists are	5
mediated modulation of the	5
role of an antiviral	5
epidemic diarrhea virus and	5
should be noted that	5
to be critical for	5
performed as described previously	5
stat and stat are	5
interferon induction cardif is	5
a limited number of	5
supernatants of a cells	5
and translocate to the	5
into the role of	5
influenza a virus replication	5
explored the possibility that	5
of the hepatitis c	5
these data indicate that	5
discussed in detail below	5
role of trim in	5
production by impeding the	5
reading of the manuscript	5
of infected epithelial cells	5
the binding of the	5
virus infection in vivo	5
enhances the innate antiviral	5
to the mitochondrial membrane	5
the presence of ns	5
japanese encephalitis virus ns	5
as a second messenger	5
immunity the rna helicase	5
after activation of the	5
nsp inhibits host gene	5
protein is required for	5
t cells grown in	5
c at an moi	5
for the control of	5
forms a complex with	5
n hm or pr	5
the cellular response to	5
to trigger the production	5
the innate response to	5
of the meaning of	5
nucleotide coding region sequences	5
in human dendritic cells	5
the cytoplasmic viral rna	5
phosphorylation of stat tyr	5
in antiviral immunity and	5
the lassa virus nucleoprotein	5
with chronic hepatitis c	5
for innate immune signaling	5
eif alpha phosphorylation and	5
an antiviral stress granule	5
sensor and an activator	5
production of proinflammatory cytokines	5
nsp protein induces template	5
as one of the	5
pathway by hepatitis c	5
which is responsible for	5
may be mediated by	5
from the severe acute	5
induced by viral infection	5
ppp rna pattern recognition	5
immune recognition of viral	5
the mavs traf traf	5
the expression of several	5
cellular type i interferon	5
each word w j	5
of innate antiviral responses	5
a wide variety of	5
and japanese encephalitis virus	5
the release of the	5
results in the production	5
protein kinase pkr and	5
the probability that the	5
a possible explanation for	5
of the cytoplasmic viral	5
signaling and effector functions	5
by targeting mitochondria and	5
may account for the	5
its activation of the	5
by interacting with rig	5
in myeloid immune cells	5
role of isg in	5
response structural basis for	5
production by targeting rig	5
with accepted academic practice	5
similar to that of	5
it will be of	5
words for scientific texts	5
as a platform for	5
the ctd and the	5
recognition by the rig	5
epsilon regulates a rig	5
detects infection with live	5
receptor recognizes bacterial dna	5
that the interaction of	5
and regulation of the	5
gene products are effectors	5
the inhibition of ifn	5
antiviral type i interferon	5
hepatitis b virus x	5
for viral replication and	5
terminal tandem card and	5
helicase domain and ctd	5
to be able to	5
be activated by the	5
antiviral innate immunity by	5
and irf visa is	5
with live listeria by	5
induction of stress granules	5
b c at an	5
antiviral signaling by regulating	5
a variety of cellular	5
the antiviral innate immune	5
structural basis for ubiquitin	5
appear to be missing	5
against a number of	5
products are effectors of	5
the transcriptional activation of	5
a vital role in	5
infection hepatitis c virus	5
by phosphorylation of the	5
recognition of viral nucleic	5
of host immune responses	5
at the cell surface	5
response to cytoplasmic dna	5
expression levels of the	5
of pkr by rnas	5
and borna disease virus	5
it should be noted	5
negative regulation of rig	5
shown to inhibit the	5
to act as an	5
a novel mechanism of	5
inhibit the production of	5
by the phosphatase pp	5
the context of the	5
sting regulates intracellular dna	5
the activation of pkr	5
establish an antiviral state	5
at the endoplasmic reticulum	5
observing the word in	5
for the generation of	5
inhibit the activity of	5
and the immune response	5
the activation of ikk	5
a signaling cascade that	5
a cells transfected with	5
secreted bacterial nucleic acids	5
and is critical for	5
signaling pathway by targeting	5
of an antiviral stress	5
for the first time	5
of the trim family	5
h n influenza virus	5
in infected cells by	5
activation of tbk and	5
targeting mitochondria and the	5
virus entry into the	5
production of infectious virus	5
the activation of stat	5
protein kinase pkr by	5
against influenza a virus	5
the translation of viral	5
produced during viral replication	5
release of the viral	5
tandem card and splice	5
enterovirus apro targets mda	5
mavs in infected cells	5
regulation of innate immune	5
antiviral stress granule containing	5
induction by the interferon	5
in the next section	5
leading to the production	5
is able to bind	5
as a regulator of	5
of the antiviral rig	5
type i interferon system	5
is an essential component	5
due to space limitations	5
immune response in the	5
linked polyubiquitin chains to	5
by sensing secreted bacterial	5
the number of matches	5
is cleaved during picornavirus	5
in innate and adaptive	5
of host restriction in	5
a novel antiviral factor	5
roles in viral replication	5
was responsible for the	5
respiratory syncytial virus non	5
a vector of frequencies	5
a better understanding of	5
rna interaction and filament	5
by influenza a virus	5
that the inhibitory effect	5
interaction between traf and	5
that of b c	5
ns targets trim to	5
type i ifn pathway	5
the number of words	5
pkr by rnas with	5
one of the major	5
proteins interact with the	5
critical reading of the	5
ubiquitination and proteasomal degradation	5
by the proteasome is	5
in the process of	5
pkr in viral detection	5
shown to negatively regulate	5
the supernatants of a	5
and type iii ifns	5
dna in the cytosol	5
induced type i interferon	5
need to be further	5
apro targets mda and	5
mediated recognition of single	5
from the er to	5
influenza a virus protein	5
in accordance with accepted	5
when it comes to	5
and type iii ifn	5
of stress granules and	5
stress granule formation by	5
of adaptor trif in	5
the innate and adaptive	5
amino acid substitution in	5
cd t cells to	5
was identified as an	5
by pattern recognition receptors	5
of patients with chronic	5
the integrity of the	5
and pkr in viral	5
were performed as described	5
immunity by targeting mitochondria	5
of gene products are	5
the release of infectious	5
viral detection and innate	5
immune response by synthetic	5
immune response against viruses	5
cyclic dinucleotide second messenger	5
is a novel antiviral	5
replication of hepatitis c	5
are also involved in	5
and an activator of	5
and it has been	5
is represented by the	5
well plates were co	5
the absence of a	5
mediated induction of ifn	5
innate immune sensor rig	5
the ifn antiviral response	5
terminal domain of the	5
viral rna sensing and	5
dna sensor and an	5
i and type ii	5
at least three times	5
for ubiquitination and degradation	5
and stimulator of retinoic	5
type i interferons in	5
rna in the cytoplasm	5
human plasmacytoid dendritic cells	5
mavs traf traf signalosome	5
are not recognized by	5
generated by rnase l	5
innate immune evasion strategies	5
b kinase subunit epsilon	5
the expression of a	5
of the ifn system	5
has been recently reported	5
antiviral signaling by interferon	5
in the united states	5
of frequencies in categories	5
paramyxoviruses bind the ifn	5
sensing secreted bacterial nucleic	5
range of gene products	5
can be used to	5
activates antiviral signaling by	5
of texts containing the	5
we explored the possibility	5
the interaction of ns	5
mitochondria and the mavs	5
of foreign nucleic acids	5
ns protein interacts with	5
this article can be	5
of the interferon antiviral	5
in the detection of	5
is an example of	5
targets mda and mavs	5
and activation of rig	5
leads to the production	5
a novel type of	5
and functional analysis of	5
regulatory factor family of	5
i ifn signaling pathway	5
linked polyubiquitination of rig	5
it is also possible	5
to viral infection and	5
context of viral infection	5
immune response mediated by	5
i and mda to	5
and cell death in	5
influenza a virus inhibits	5
a platform for the	5
representation of the situation	5
dependent activation of pkr	5
intracellular nucleic acid sensors	5
viral interferon regulatory factor	5
is regulated by the	5
of ube l in	5
the development of novel	5
for degradation by the	5
of the flaviviridae family	5
is not the only	5
the innate antiviral immune	5
suppression of innate antiviral	5
i interferon induction cardif	5
also been implicated in	5
of viral rna to	5
during rna virus infection	5
of acute lower respiratory	5
the inhibition of type	5
suppresses innate immunity by	5
the e ligase trim	5
targets trim to suppress	5
b suppresses innate immunity	5
the dub activity of	5
in viral detection and	5
suppresses type i interferon	5
inhibits the ubiquitination of	5
interaction and filament assembly	5
discussed in this review	5
gene induction by the	5
against emcv and jev	5
the viral replication complex	5
between host innate antiviral	5
of unmethylated cpg motifs	5
irf visa is an	5
with the innate immune	5
has been linked to	5
capable of binding to	5
inhibit its activation of	5
mediated antiviral activity ubiquitin	5
i has been shown	5
an essential function of	5
mda and mavs in	5
and inhibit its activation	5
informative words in the	5
interferon regulatory factor is	5
categories that the text	5
the activity of ifn	5
h n hm or	5
as a result of	5
the contribution of the	5
in response to dsrna	5
further studies are required	5
consistent with this notion	5
in the endoplasmic reticulum	5
i has also been	5
through the inhibition of	5
effectors of the type	5
inhibitory effect of ns	5
is possible that the	5
been shown to act	5
by their s j	5
by binding to the	5
splice variant in trim	5
the expression of tbk	5
factor family of transcription	5
involved in the activation	5
critical role of an	5
higher order rna structures	5
motifs in bacterial dna	5
ifn in response to	5
cytosolic dna sensor and	5
a novel mechanism for	5
the presence of the	5
been shown to target	5
of the meaning space	5
of a word in	5
cpg motifs in bacterial	5
translocation of irf and	5
a complex with the	5
expressing plasmid or empty	4
and the dsrna replicative	4
specific protease ul inhibits	4
s j or m	4
viral rna species were	4
viral rna replication and	4
to the cell surface	4
induces its proteasomal degradation	4
coronaviruses as the gene	4
type lectin receptor and	4
k modulates nucleocapsid inhibition	4
for the initiation of	4
interaction between irf and	4
where it binds to	4
denv inhibits type i	4
the interface of innate	4
the brain causing lethal	4
not induce type i	4
polymorphism is associated with	4
the second binding pocket	4
innate immunity structural basis	4
the cytoplasm of cells	4
a number of other	4
antagonizes interferon beta production	4
k k k k	4
protease cleaves mavs and	4
resistance to type i	4
two caspase activation and	4
terminal domain of rig	4
the regulation of rlr	4
the molecular basis of	4
attenuate host type i	4
it is therefore not	4
of the n protein	4
chronic hepatitis c virus	4
ubiquitin ligase mex c	4
the increase in the	4
role of type i	4
deaminases acting on rna	4
in respiratory syncytial virus	4
like protease from the	4
interest to see whether	4
defined on texts that	4
of innate immune proteins	4
of their genetic material	4
with enzyme from interferon	4
as well as nf	4
type i ifn by	4
representation of a situation	4
of innate immunity due	4
the activation of mavs	4
antibody was purchased from	4
i results in activation	4
k and k of	4
c virus ns b	4
a prime and realign	4
i ifns and other	4
stimulated gene functions as	4
cytokine production in response	4
host factors required for	4
i translocation to the	4
nucleotide polymorphisms of the	4
and induces its proteasomal	4
cultured on glass coverslips	4
an undetermined nucleotide and	4
human bronchial epithelial cells	4
in all cell types	4
be ordered by their	4
the presence of viral	4
oasl protein is mediated	4
essential components of innate	4
structure of isg reveals	4
by human respiratory syncytial	4
viral rna in the	4
i like receptor mda	4
role of traf in	4
virus ns protein to	4
been shown that the	4
in the cytosolic dna	4
like receptors and cytosolic	4
ns and ns of	4
of a number of	4
crystal structure of rig	4
receptor mediates west nile	4
m protein inhibits type	4
inhibits stress granule formation	4
acute respiratory distress syndrome	4
with irf to form	4
most informative n words	4
activation by limiting the	4
catalyzes the synthesis of	4
and potential functional mechanisms	4
for the production of	4
of an rsv infection	4
of its ability to	4
like protease has deisgylating	4
expressed on the cell	4
cov orf b protein	4
antiviral immunity in mammals	4
conventional and unconventional mechanisms	4
regulation of rlr signaling	4
adenosine deaminases acting on	4
is the metazoan second	4
by ubiquitin and ubiquitin	4
rnase l releases a	4
the function of interferon	4
further studies are needed	4
novel rna binding structure	4
in the levels of	4
activation of the transcription	4
a critical role for	4
into the brain causing	4
dependent stimulation of the	4
ligands of mda and	4
phosphorylation of stat and	4
by an unknown mechanism	4
respiratory syncytial virus and	4
mrnas transcribed in the	4
nucleoprotein reveals a dsrna	4
roles of trims in	4
of triphosphate by rig	4
to negatively regulate rig	4
virus hepatitis c virus	4
are required for the	4
jak stat signaling pathway	4
vp protein and the	4
pge in the culture	4
with a type i	4
coronavirus nonstructural protein nsp	4
a virus c protease	4
for each word w	4
rational design of new	4
functioning in diverse cellular	4
leads to the phosphorylation	4
of the replication cycle	4
activation of stat by	4
modifier fat attenuates rig	4
lymphotropic virus type i	4
were shown to be	4
second messenger produced by	4
trim recognition and inhibition	4
i and mda share	4
network of modified endoplasmic	4
master sensors of pathogenic	4
immune defense against mouse	4
expressed proteins functioning in	4
mrna stability and translatability	4
is plausible that rnase	4
into a potent pamp	4
rna with a triphosphate	4
vitro hepatitis c virus	4
mediated antiviral signaling pathway	4
to note that the	4
wave of type i	4
card domain of rig	4
to facilitate viral replication	4
to be crucial for	4