trigram

This is a table of type trigram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

trigram	frequency
type i ifn	468
type i interferon	312
hepatitis c virus	308
of type i	280
i and mda	258
innate immune response	236
the activation of	236
the innate immune	218
the expression of	212
been shown to	201
as well as	186
influenza a virus	173
the induction of	150
activation of the	144
in response to	140
innate immune responses	137
the production of	136
type i ifns	133
the formation of	129
the type i	122
has been shown	119
the role of	118
respiratory syncytial virus	117
respiratory syndrome coronavirus	112
is essential for	104
is required for	103
of the rig	103
involved in the	103
interferon regulatory factor	102
severe acute respiratory	101
acute respiratory syndrome	100
of the viral	99
of innate immune	94
e ubiquitin ligase	92
i ifn production	91
the presence of	88
in addition to	85
innate immune system	85
tlr and tlr	85
innate immune signaling	82
the absence of	80
ns and ns	80
it has been	79
have been shown	78
the recognition of	75
hek t cells	74
and activation of	74
of the ifn	71
role in the	69
in the cytoplasm	69
was shown to	69
west nile virus	68
herpes simplex virus	67
the interaction between	67
in innate immunity	66
antiviral innate immunity	66
the interaction of	65
of viral rna	65
one of the	64
the inhibition of	64
pattern recognition receptors	64
i ifn response	64
the regulation of	63
structural basis for	63
antiviral innate immune	63
in the cytosol	63
mitochondrial antiviral signaling	62
a variety of	62
in order to	61
production of type	60
in the absence	60
of the innate	60
type i interferons	60
has also been	58
plasmacytoid dendritic cells	57
a role in	56
antiviral signaling protein	56
shown to be	56
cells infected with	56
the level of	56
to the nucleus	56
virus ns protein	56
i ifn signaling	55
a number of	55
induction of type	55
strand rna viruses	54
is involved in	54
immune response to	54
been found to	53
regulation of the	52
east respiratory syndrome	52
middle east respiratory	52
the activity of	51
on the other	51
in mammalian cells	51
of hepatitis c	51
i interferon production	51
in the regulation	51
leading to the	51
porcine epidemic diarrhea	51
ubiquitination of rig	50
the importance of	50
is associated with	50
type i and	49
the effect of	49
in the nucleus	49
innate antiviral response	49
of the type	48
antiviral response by	48
found to be	48
crystal structure of	48
activation of nf	48
kato et al	48
in infected cells	48
a virus ns	47
the other hand	47
induction of ifn	47
members of the	47
the development of	47
resulting in the	46
the cells were	46
has been reported	46
japanese encephalitis virus	46
by hepatitis c	46
in this review	46
word w j	46
epidemic diarrhea virus	46
to interact with	46
the ability of	45
during viral infection	45
of interferon regulatory	45
is mediated by	45
cd t cells	45
such as the	45
been reported to	45
inducible gene i	44
have also been	44
an important role	44
like receptors and	44
stress granule formation	44
host innate immune	44
in contrast to	43
the immune response	43
is critical for	43
tumor necrosis factor	43
of the interferon	43
structure of the	43
member of the	42
interacts with the	42
is able to	42
activation of rig	42
also known as	42
negative regulation of	42
of the host	42
are involved in	42
activation of irf	41
expression of the	41
essential for rig	41
results in the	41
the number of	41
by the innate	41
recognition by the	41
production of ifn	41
acts as a	40
innate and adaptive	40
i ifn induction	40
leads to the	40
which in turn	40
responsible for the	40
the function of	40
of influenza a	40
of rna viruses	40
the release of	39
innate antiviral responses	39
binds to the	39
like receptor signaling	39
of nucleic acid	39
rna polymerase iii	39
the rna helicase	39
in the recognition	38
important role in	38
i interferon signaling	38
interaction with the	38
the meaning of	38
associated molecular patterns	38
the viral rna	38
viral nucleic acids	38
the ns protein	38
have been identified	38
i and iii	38
the ubiquitin ligase	38
in the activation	37
viral replication and	37
in the context	37
to viral infection	37
recognition of viral	37
and characterization of	37
activated protein kinase	37
the context of	37
mediated type i	37
were transfected with	37
rna recognition by	37
category c k	37
the phosphorylation of	37
nucleic acid immunity	36
the immune system	36
mda and rig	36
the recruitment of	36
irf and irf	36
c virus infection	36
of irf and	36
of innate immunity	35
protein kinase pkr	35
inhibits type i	35
in the presence	35
is responsible for	35
the word w	35
of the virus	35
recognition of rna	35
interferon production by	35
the transcription of	35
mediated antiviral responses	35
role of the	35
dependent on the	35
the n protein	35
the adaptor protein	35
to type i	34
in innate immune	34
the ubiquitination of	34
the category c	34
of mda and	34
of the rna	34
the most informative	34
was found to	34
in the rig	34
rna sensor rig	34
innate immune sensor	33
binding to the	33
hornung et al	33
of viral replication	33
in type i	33
vesicular stomatitis virus	33
antiviral immune responses	33
protein kinase r	33
the binding of	33
i interferon induction	33
the ability to	33
the replication of	33
inhibition of the	33
have shown that	33
the use of	33
are required for	32
wang et al	32
in cells infected	32
associated with the	32
well as the	32
functions as a	32
of the immune	32
is activated by	32
mhc class i	32
due to the	32
and degradation of	32
were infected with	32
play a role	32
t cells were	32
by the host	32
is targeted by	32
stranded rna and	32
dexd h box	32
of the antiviral	32
influenza virus infection	32
in this study	32
ubiquitin ligase trim	31
expression of type	31
activation of ifn	31
of viral infection	31
negative regulator of	31
by interacting with	31
analysis of the	31
into the nucleus	31
ebola virus vp	31
be activated by	31
the degradation of	31
is dependent on	31
ifn production in	31
words in the	30
the cell surface	30
reproductive and respiratory	30
have been reported	30
in antiviral innate	30
rlr signaling pathway	30
in the host	30
immune responses to	30
of innate antiviral	30
ifn induction by	30
nuclear translocation of	30
linked polyubiquitination of	30
the case of	30
emcv and jev	30
porcine reproductive and	30
in the induction	30
innate immune evasion	30
activity of the	30
the innate antiviral	30
the ifn system	30
identification and characterization	29
viral rna sensor	29
the e ubiquitin	29
mediated antiviral signaling	29
also been shown	29
antiviral signaling by	29
human immunodeficiency virus	29
rna virus infection	29
it is possible	29
recognized by rig	29
the viral genome	29
the control of	29
essential for the	29
and respiratory syndrome	29
most informative words	28
the generation of	28
mediated by the	28
an essential function	28
c virus ns	28
immune response in	28
immune responses in	28
to inhibit the	28
recognition by rig	28
has not been	28
degradation of the	28
traf and traf	28
the host innate	28
based on the	28
linked ubiquitination of	28
components of the	28
a member of	28
a negative regulator	28
in the case	28
the ifn response	28
the suppression of	28
ifn production and	27
the identification of	27
innate immunity by	27
a type i	27
required for the	27
i signaling by	27
induced activation of	27
been shown that	27
respiratory syndrome virus	27
appears to be	27
cells were transfected	27
of a word	27
is possible that	27
to induce ifn	27
in hek t	27
in the innate	27
part of the	27
mediated activation of	27
innate immunity and	27
c virus rna	27
mda and lgp	27
remains to be	27
we found that	27
addition to the	27
and innate immunity	27
structural basis of	27
the host immune	27
inhibition of rig	27
to induce the	26
yoneyama et al	26
a critical role	26
response to viral	26
virus nonstructural protein	26
function of the	26
type lectin receptors	26
immune response by	26
basis for the	26
of ns and	26
the helicase domain	26
to bind to	26
some of the	26
of the most	26
newcastle disease virus	26
required for virus	26
the fact that	26
hepatitis b virus	26
interact with the	26
be involved in	26
dna and rna	26
by rna viruses	26
the severe acute	26
has been demonstrated	25
the nucleus and	25
the detection of	25
understanding of the	25
suggesting that the	25
to be a	25
to the activation	25
ligand for rig	25
cov and mers	25
the association of	25
component of the	25
a recent study	25
of viral proteins	25
is important for	25
proteins have been	25
infected with the	25
insights into the	25
viruses such as	25
the host cell	25
essential function in	25
single nucleotide polymorphisms	25
indicating that the	25
regulation of rig	25
its interaction with	25
as shown in	25
our understanding of	24
has an essential	24
t cells and	24
mediated antiviral activity	24
as a result	24
krug et al	24
an antiviral state	24
activation of innate	24
the antiviral response	24
the synthesis of	24
of stress granules	24
induced innate antiviral	24
binding of the	24
to the category	24
antiviral immune response	24
human respiratory syncytial	24
i has an	24
by the viral	24
expression of ifn	24
for scientific texts	24
activator of transcription	24
interferon antiviral response	24
rna helicase rig	24
i ifn responses	24
with the indicated	24
for the activation	24
the accumulation of	24
the lack of	24
regulation of innate	24
spry domain of	24
belongs to the	24
and function of	24
by binding to	24
a series of	24
allele of rs	24
li et al	24
signal transducer and	24
is a novel	24
host innate immunity	24
methylation of the	23
end of the	23
functions of the	23
its ability to	23
seems to be	23
irf and nf	23
transducer and activator	23
pichlmair et al	23
identified as a	23
are responsible for	23
according to the	23
the meaning space	23
the influenza a	23
of influenza virus	23
have been described	23
antiviral responses to	23
in patients with	23
virus infection and	23
of the signaling	23
and activator of	23
is one of	23
response by targeting	23
protein in the	23
virus replication and	23
stat and stat	23
domain of trim	23
showed that the	22
laboratory of genetics	22
by retinoic acid	22
the mechanism of	22
the nucleus to	22
linked polyubiquitin chains	22
the pathogenesis of	22
an adaptor protein	22
been identified as	22
has been found	22
to be the	22
formation of the	22
in vitro and	22
viral rna replication	22
of the first	22
dependent innate immune	22
antiviral activity of	22
svv c pro	22
it is also	22
can be found	22
strand rna virus	22
repressor domain in	22
i ifns and	22
saito et al	22
of genetics and	22
genetics and physiology	22
viral rna species	22
cytokines and chemokines	22
the majority of	22
rna in the	22
are associated with	22
the crystal structure	22
induce type i	22
present in the	22
are recognized by	22
is an essential	22
by interfering with	22
as a negative	22
the involvement of	21
adaptive immune response	21
and the activation	21
interferon signaling by	21
by type i	21
mediated inhibition of	21
can also be	21
is important to	21
translation initiation factor	21
the loss of	21
ubiquitin ligase is	21
has been identified	21
and mda signaling	21
innate immune receptor	21
regulator of rig	21
k and k	21
ifn production by	21
mouth disease virus	21
induces type i	21
ligase is essential	21
critical role in	21
i interferon response	21
be found in	21
a positive regulator	21
and nuclear translocation	21
helicases in the	21
space of meaning	21
i ifn and	21
and innate immune	21
its role in	21
in the ifn	21
sensing of viral	21
ifn regulatory factor	21
but not in	21
viruses have evolved	21
of the ubiquitin	21
the e ligase	21
is crucial for	21
differential roles of	21
interaction between rig	21
to note that	21
mediated innate immune	21
are essential for	21
upon binding to	20
plays a role	20
in the antiviral	20
of tlr and	20
immune signaling by	20
of words in	20
mediated degradation of	20
type iii ifn	20
vitro and in	20
for innate immune	20
these results indicate	20
the nlrp inflammasome	20
self and non	20
increase in the	20
roles of mda	20
i helicases in	20
ring finger protein	20
category rig matrix	20
and is targeted	20
bat cell lines	20
ns protein of	20
contribute to the	20
oshiumi et al	20
the cytosol of	20
mediated recognition of	20
which leads to	20
was identified as	20
structural and functional	20
in which the	20
activation and recruitment	20
studies suggest that	20
cells were lysed	20
their ability to	20
the ligand for	20
the transcription factors	20
positive regulator of	20
to virus infection	20
essential role of	20
type iii ifns	20
induced by rig	20
of rnase l	20
expression levels of	20
the card domain	20
located in the	20
to play a	20
by viral rna	20
critical for the	20
the endoplasmic reticulum	20
the interferon antiviral	20
interfere with the	20
signaling pathway in	20
of protein synthesis	19
polyubiquitination of the	19
immune sensing of	19
of proinflammatory cytokines	19
is necessary for	19
recognition of double	19
in the production	19
adaptive immune responses	19
viral infection and	19
at the end	19
is the ligand	19
to be involved	19
regulation of interferon	19
alpha beta interferon	19
the levels of	19
and in vivo	19
by the proteasome	19
of viral nucleic	19
induced type i	19
virus ns targets	19
antiviral responses by	19
degradation of irf	19
leads to a	19
of the transcription	19
host antiviral response	19
in plasmacytoid dendritic	19
signaling by the	19
rna is the	19
h box rna	19
of tlr in	19
of the trim	19
triphosphate rna is	19
the host antiviral	19
of meaning for	19
viral nucleic acid	19
proteasomal degradation of	19
the possibility that	19
function in double	19
known to be	19
to the cytoplasm	19
virus vp protein	19
play an important	19
targeted by hepatitis	19
cells were infected	19
the dexd h	19
are able to	19
mechanisms by which	19
studies have shown	19
of the rlr	19
domain of the	19
effect of ns	19
the end of	19
with or without	19
i or mda	19
distinction of self	19
caspase activation and	19
related to the	19
innate antiviral immunity	19
domain of rig	19
inhibition of ifn	19
and adaptive immunity	19
yoneyama and fujita	19
and type i	19
by targeting rig	19
cells transfected with	18
phosphorylation of irf	18
evade recognition by	18
the ns a	18
been demonstrated to	18
protein that activates	18
act as a	18
a mitochondrial antiviral	18
most of the	18
activation of pkr	18
acting as a	18
characterization of mavs	18
lead to the	18
been reported that	18
in the text	18
rna recognition and	18
phosphorylation of the	18
of traf and	18
meaning of a	18
for the development	18
has been described	18
the influenza virus	18
results showed that	18
line of defense	18
c virus replication	18
activation of type	18
been implicated in	18
in a cells	18
cellular antiviral response	18
negatively regulates the	18
stranded rna bearing	18
antiviral signal activation	18
of ube l	18
schlee et al	18
responses to single	18
signaling protein that	18
degradation by the	18
host immune response	18
for viral replication	18
a novel mechanism	18
on the cell	18
o methylation of	18
need to be	18
irie et al	18
a role for	18
rna viruses in	18
to evade recognition	18
is a negative	18
innate immunity the	18
of the n	18
activation of interferon	18
to activate rig	18
of rlr signaling	18
it is important	18
results indicate that	18
that activates nf	18
mechanism by which	18
in the formation	18
recognition of single	18
different types of	18
antiviral response through	18
cells were seeded	18
is an adaptor	18
of isg and	18
plays an important	18
by western blotting	18
cell lysates were	18
e ligase activity	18
for the induction	18
virus ns a	18
the rna sensor	17
meaning for scientific	17
first line of	17
molecular mechanism of	17
of cytokine signaling	17
inhibition of interferon	17
the course of	17
mediated cleavage of	17
h n virus	17
cd t cell	17
the spry domain	17
the inhibitory effect	17
the distinction of	17
of the human	17
of the nf	17
of protein kinase	17
data suggest that	17
of the two	17
kappab and irf	17
informational space of	17
signal activation by	17
implicated in the	17
of beta interferon	17
infected with iav	17
and melanoma differentiation	17
belong to the	17
the cleavage of	17
cellular and viral	17
in t cells	17
conflict of interest	17
the authors declare	17
ubiquitination and degradation	17
the cytoplasm of	17
to interfere with	17
the interferon response	17
a family of	17
as described above	17
to the c	17
i and lgp	17
box rna helicase	17
structural insights into	17
mediated induction of	17
virus replication by	17
immune response and	17
the structure of	17
proteins involved in	17
consistent with the	17
the assembly of	17
rna viruses to	17
foreign nucleic acids	17
and iii ifns	17
the hepatitis c	17
to determine the	17
pathway and is	17
of transcription factors	17
in the c	17
semliki forest virus	17
rna viruses and	17
is induced by	17
an essential role	17
are known to	17
ligase trim to	17
inhibitory effect of	17
the roles of	17
and dendritic cells	17
in vitro transcription	17
the antiviral activity	17
found that the	17
i like receptors	17
it is not	17
by blocking the	16
by innate immune	16
unanchored polyubiquitin chains	16
an adaptor triggering	16
the discovery of	16
polymorphisms of genes	16
and the host	16
viral mrna cap	16
upon viral infection	16
an innate immune	16
and adaptive immune	16
immune receptor rig	16
has been proposed	16
immune signaling pathways	16
similar to the	16
important roles in	16
replication and spread	16
i activation by	16
will be discussed	16
the viral mrna	16
the card domains	16
of the cellular	16
in line with	16
cardif is an	16
of ifn production	16
viral and cellular	16
results in a	16
in the cell	16
found in the	16
induction of an	16
mouse hepatitis virus	16
of the irf	16
contributes to the	16
in a dose	16
induced by the	16
antiviral pathway and	16
of a novel	16
in the pathogenesis	16
also involved in	16
at h p	16
rna helicase lgp	16
the host viral	16
trim to evade	16
the transcription factor	16
of trim in	16
i interferon and	16
appear to be	16
isg and its	16
to suppress the	16
in the immune	16
recruitment of the	16
also been found	16
of genes encoding	16
adaptor protein in	16
early phase of	16
thought to be	16
acid inducible gene	16
serves as a	16
phosphorylation of stat	16
innate immune recognition	16
immune response against	16
suppression of rig	16
i antiviral pathway	16
the signaling cascade	16
targets the ubiquitin	16
of retinoic acid	16
ns targets the	16
adaptor triggering rig	16
the rna sensors	16
is also a	16
of the word	16
of trims in	16
in the human	16
suppressor of cytokine	16
host viral rna	16
expression level of	16
to negatively regulate	16
in vitro transcribed	16
characterization of the	16
of the toll	16
of the cards	16
feedback regulation of	16
is the first	16
bind to the	16
proteins that are	16
recognized by the	16
were found to	16
in viral replication	16
modulation of the	16
influenza b virus	16
pathogen recognition and	16
encoded by the	16
versus the iav	16
terminal domain of	15
of nucleic acids	15
of positive selection	15
and a c	15
led to the	15
expression of rig	15
mavs signaling pathway	15
it is likely	15
associated with a	15
has recently been	15
of porcine epidemic	15
activity of trim	15
ubiquitin ligase rnf	15
suggests that the	15
is recognized by	15
the downstream signaling	15
be explained by	15
induction by the	15
antiviral immunity in	15
regulation of antiviral	15
finger e ubiquitin	15
eukaryotic translation initiation	15
not required for	15
tbk and ikk	15
lu et al	15
shown that the	15
formation of a	15
words in categories	15
as described previously	15
innate immune sensors	15
downstream of the	15
is the most	15
an e ubiquitin	15
replication and transcription	15
and or ns	15
as found in	15
is an important	15
viral replication by	15
depending on the	15
myeloid dendritic cells	15
the response to	15
and dna viruses	15
the site of	15
chronic hepatitis c	15
informative words in	15
structure and function	15
the mitochondrial membrane	15
reviewed in ref	15
by the ubiquitin	15
to activate the	15
viral genomic rna	15
of gene expression	15
for activation of	15
assembly of the	15
activation of tbk	15
and inhibition of	15
the protein kinase	15
mediated signaling by	15
shown to inhibit	15
response to infection	15
virus rna replication	15
ablasser et al	15
sitosterol on the	15
as an antiviral	15
stranded rna viruses	15
of isg in	15
of viral dsrna	15
a conformational change	15
was reported to	15
to that of	15
innate antiviral immune	15
as a novel	15
and tlr are	15
recognition receptors and	15
translocate to the	15
due to its	15
i and mavs	15
and cell death	15
a virus infection	15
effector functions of	15
in the past	15
the phosphorylation and	15
yet to be	15
interaction of the	15
expression of isgs	15
be responsible for	15
viral rna to	15
is represented by	15
can be activated	15
the evolution of	15
is independent of	15
induce the expression	15
of the influenza	15
an immune response	15
the observation that	15
stranded rna in	15
kim et al	15
dependent recognition of	15
gack et al	15
roles in the	15
immune responses and	15
of severe acute	15
is regulated by	15
of the text	15
shown to bind	15
of the protein	15
identified as an	15
and recruitment domains	15
dependent protein kinase	15
which is a	15
recognition receptors in	15
to determine whether	15
innate immune pattern	15
antiviral defenses through	15
a word is	15
a vector of	14
to rna virus	14
signaling role of	14
function as a	14
host and viral	14
of the ctd	14
rna and dna	14
interaction between trim	14
cytosolic dna and	14
and the c	14
the sensing of	14
the word in	14
to induce type	14
and stress granule	14
nucleic acid sensors	14
iav control group	14
which can be	14
stranded rna as	14
for each word	14
can act as	14
production and signaling	14
or infected with	14
to activate ifn	14
functions as an	14
not yet been	14
beta interferon production	14
by the ns	14
during virus infection	14
in this section	14
rna sensor mda	14
trim interacts with	14
text belongs to	14
or absence of	14
interaction with mavs	14
human dendritic cells	14
activation of stat	14
dependent innate immunity	14
were treated with	14
ubiquitination of the	14
identified as the	14
the adaptive immune	14
of cytosolic dna	14
production induced by	14
binding oligomerization domain	14
results suggest that	14
positive and negative	14
recognition of the	14
is a positive	14
but not the	14
inflammatory cytokines and	14
absence of the	14
takahasi et al	14
a cells were	14
of the mammalian	14
to inhibit ifn	14
resulting in a	14
retinoic acid inducible	14
syncytial virus nonstructural	14
by the influenza	14
there is no	14
to the production	14
supported by the	14
are capable of	14
of an antiviral	14
rna sensors rig	14
a set of	14
demonstrated that the	14
and proinflammatory cytokines	14
is sufficient to	14
are targeted by	14
ectopic expression of	14
between trim and	14
the viral replication	14
a ring finger	14
cys and his	14
of the ns	14
shown to play	14
are important for	14
by viruses to	14
of the cell	14
ns and or	14
the amount of	14
to activate and	14
gitlin et al	14
followed by the	14
more susceptible to	14
i interferon pathway	14
tbk and irf	14
is inhibited by	14
of the three	14
the early phase	14
in human cells	14
and it is	14
finger antiviral protein	14
can be used	14
h n influenza	14
an increase in	14
region of the	14
and laboratory of	14
an overview of	14
of self and	14
ifit and ifit	14
yang et al	14
to evade innate	14
to be determined	14
innate antiviral defenses	14
in complex with	14
were shown to	14
supplementary figure s	14
explained by the	14
on the rna	14
protein interacts with	14
protein has been	14
dependent rna polymerase	14
helicase domain and	14
induction of isg	14
it was shown	14
the first line	14
regulatory factor activation	14
interfering with trim	14
regulator of the	14
like receptor and	14
of hundreds of	14
shown to induce	14
in dendritic cells	14
diebold et al	14
binding to dsrna	14
unfolded protein response	14
expression of trim	14
suggest that the	14
ifn response in	14
critical role of	14
expression of ns	14
is capable of	13
involvement of rig	13
the rlr pathway	13
crucial role in	13
rna as contained	13
is a key	13
role of tlr	13
the ifn signaling	13
presence or absence	13
these data suggest	13
of cd t	13
in the word	13
and regulation of	13
interaction between the	13
requires short blunt	13
specific recognition of	13
influenza a viruses	13
defenses through a	13
of defense against	13
proteins in the	13
protein is a	13
in a cell	13
and activates the	13
to the n	13
these results suggest	13
in each category	13
activation in the	13
a shared repressor	13
domain in rig	13
the ns proteins	13
interferon induction and	13
localized in the	13
innate immune signalling	13
simplex virus type	13
triphosphate by rig	13
new insights into	13
to suppress rig	13
into the cytoplasm	13
of the adaptor	13
rnase l in	13
may also be	13
be due to	13
and viral rna	13
word in the	13
i and melanoma	13
is supported by	13
to antagonize ifn	13
interacting with the	13
seneca valley virus	13
the contribution of	13
virus c protein	13
as a viral	13
linked to the	13
reported to be	13
innate immune receptors	13
and type iii	13
i ubiquitination and	13
of sendai virus	13
were seeded in	13
induction of the	13
and mda are	13
s j and	13
is expressed in	13
trim in the	13
cytosolic dna sensor	13
ifit family members	13
used by viruses	13
and in the	13
is known to	13
as a strategy	13
host gene expression	13
level of isg	13
for type i	13
induces the expression	13
the impact of	13
important for the	13
of rna recognition	13
the expression levels	13
dependent activation of	13
of pattern recognition	13
ubiquitin e ligase	13
serve as a	13
c k w	13
that can be	13
of antiviral innate	13
study showed that	13
arms race between	13
viral rna by	13
identification of the	13
observed in the	13
genes in the	13
contained in panhandle	13
during viral replication	13
i ifn in	13
activated by the	13
of virus replication	13
and cellular antiviral	13
shared repressor domain	13
during the early	13
interferon regulatory factors	13
as contained in	13
i helicase requires	13
with tetratricopeptide repeats	13
through a shared	13
with the card	13
has been recently	13
the stability of	13
at the level	13
panhandle of negative	13
hemmi et al	13
molecular mechanisms of	13
translocation of irf	13
c protease cleaves	13
activation of antiviral	13
interacts with rig	13
viruses have been	13
evade innate immunity	13
helicase requires short	13
a and b	13
were incubated with	13
virus kato et	13
a crucial role	13
lgp is a	13
at the n	13
ifn responses to	13
of the dexd	13
been identified in	13
a decrease in	13
but not rig	13
are activated by	13
i is the	13
have not been	13
overview of the	13
for the distinction	13
for inhibition of	13
can bind to	13
was supported by	13
polyubiquitin chains in	13
to counteract the	13
signaling pathway by	13
translation of viral	13
viral rna and	13
was the first	13
in terms of	13
and lgp in	13
induction of interferon	13
yellow fever virus	13
innate immune sensing	13
reactive oxygen species	13
viral rna recognition	13
of an rna	13
activation of mda	13
production in response	13
direct interaction of	13
in panhandle of	13
syndrome coronavirus papain	12
have demonstrated that	12
i by viral	12
wide range of	12
transcription factors irf	12
a wide range	12
of isg conjugates	12
evasion of the	12
and induces type	12
inhibition of translation	12
of patients with	12
is likely that	12
in host defense	12
rigs in categories	12
lectin receptors and	12
shown to interact	12
in the expression	12
findings suggest that	12
to form the	12
of these viruses	12
and the monolayer	12
to the host	12
oas rnase l	12
infected with drv	12
model of rig	12
by influenza virus	12
that ns and	12
pedv n protein	12
in this case	12
in myeloid dendritic	12
coronavirus nonstructural protein	12
the existence of	12
dependent signaling pathway	12
visa is an	12
trim negatively regulates	12
adapter protein required	12
necrosis factor receptor	12
an rsv infection	12
unique functions of	12
which has been	12
ns a and	12
the antiviral immune	12
monolayer cells were	12
consistent with this	12
detection by rig	12
antiviral signal transduction	12
receptors and rig	12
shared and unique	12
that binds to	12
by ifit family	12
is thought to	12
as previously described	12
mda and mavs	12
myeloid differentiation primary	12
the translation of	12
it was found	12
be essential for	12
dna in the	12
viral replication in	12
by the e	12
the mechanisms by	12
and rna viruses	12
directly interacts with	12
to form a	12
mediated antiviral response	12
rna with a	12
different cell types	12
domains of rig	12
i activation and	12
is that the	12
ns a protease	12
and the viral	12
only in the	12
an inhibitor of	12
and his residues	12
gao et al	12
levels of ifn	12
role of unanchored	12
the functions of	12
gene expression by	12
n protein inhibits	12
chen et al	12
trim is a	12
revealed that the	12
eif a phosphorylation	12
rna virus replication	12
jak stat pathway	12
of infected cells	12
k w j	12
in activation of	12
receptors and their	12
of herpes simplex	12
the present study	12
heil et al	12
cells in the	12
in influenza virus	12
inhibition of hiv	12
of antiviral immune	12
stimulator of interferon	12
an adapter protein	12
as part of	12
and unique functions	12
production and antiviral	12
of viral infections	12
i and type	12
bound to the	12
cells treated with	12
sars coronavirus papain	12
lgp in antiviral	12
are present in	12
in hepatitis c	12
the mitochondrial antiviral	12
kawai et al	12
as a potential	12
plays a critical	12
is a major	12
mechanism of trim	12
isg e ligase	12
pathway reveals a	12
ubiquitination of traf	12
be discussed in	12
the interferon regulatory	12
small interfering rna	12
intestinal epithelial cells	12
cleavage of the	12
and inflammatory cytokines	12
immune evasion strategies	12
recent studies have	12
tlr is expressed	12
protein of influenza	12
of cellular mrnas	12
the infected cells	12
contribution of the	12
natural killer cells	12
mechanism of rig	12
immune responses by	12
i pathway reveals	12
innate immunity to	12
the treatment of	12
seem to be	12
protein required for	12
reported that the	12
negative feedback regulation	12
in antiviral immunity	12
it will be	12
specific inhibition of	12
rna and activation	12
to be essential	12
the host response	12
of unanchored polyubiquitin	12
ifn induction in	12
ns a protein	12
that the ns	12
has been implicated	12
pattern recognition receptor	12
activation of tlr	12
were analyzed by	12
in the same	12
to act as	12
open reading frame	12
ifn response to	12
antiviral effect of	12
host immune system	12
ubiquitin ligase and	12
to target proteins	12
targeted by the	12
with the n	12
and that the	12
to activation of	12
and mda have	12
virus infection in	12
syncytial virus infection	12
box helicases rig	12
reconstitution of the	12
evolution of the	12
paramyxovirus v proteins	12
protein synthesis by	12
been described to	12
was shown that	12
borne encephalitis virus	12
airway epithelial cells	12
in antiviral response	12
the list of	12
for h at	12
with the ifn	12
in the control	12
genes encoding c	12
single nucleotide polymorphism	12
the mechanism by	12
for the antiviral	12
i interferons and	12
is characterized by	12
the viral capsid	12
it does not	12
is an adapter	12
between self and	12
acute promyelocytic leukemia	12
the monolayer cells	12
i interferon in	12
chains in innate	12
viral rna synthesis	12
this work was	12
protein kinase c	12
signaling cascade that	11
ifn signaling by	11
is the probability	11
large tegument protein	11
regulated by the	11
autocrine and paracrine	11
in a manner	11
marques et al	11
for dsrna recognition	11
in the level	11
the exception of	11
protease ns a	11
irf transcription factor	11
as compared to	11
account for the	11
and analyzed by	11
lung epithelial cells	11
the tlr signaling	11
as in the	11
is a cytosolic	11
the molecular mechanisms	11
antiviral stress granule	11
focus on the	11
the cytoplasm and	11
i in antiviral	11
antiviral state in	11
changes in the	11
host innate antiviral	11
role of isg	11
degradation of rig	11
i ifn expression	11
weber et al	11
on the ifn	11
adaptor protein mita	11
the antiviral effect	11
is not required	11
signaling by targeting	11
the understanding of	11
in the category	11
between ns and	11
aggregates to activate	11
to have a	11
upon binding of	11
hepatitis a virus	11
of the genome	11
signaling pathway through	11
able to bind	11
for virus replication	11
expression of a	11
host restriction by	11
these findings suggest	11
their interaction with	11
forms functional prion	11
formation of stress	11
like receptors the	11
in the inhibition	11
expression of proinflammatory	11
phase of viral	11
of antiviral responses	11
of the chicken	11
entry into the	11
immune response is	11
ribonucleic acids by	11
on the contrary	11
at the same	11
to activate antiviral	11
of infectious virus	11
of dengue virus	11
short blunt double	11
and iii ifn	11
by targeting the	11
words in each	11
detection of viral	11
interferon response to	11
as an e	11
to prevent the	11
to the expression	11
in the infected	11
card domains of	11
cytosolic dna sensing	11
from the word	11
translocation to the	11
with the exception	11
antiviral responses the	11
found in arenavirus	11
virus c protease	11
activate antiviral signaling	11
zhao et al	11
a signaling role	11
alexopoulou et al	11
a molecular signature	11
together with the	11
response by the	11
context of viral	11
large number of	11
impact on the	11
of immune cells	11
jiang et al	11
the jak stat	11
interaction between ns	11
of cellular proteins	11
and the induction	11
virus core protein	11
result in the	11
activation by rig	11
an endoplasmic reticulum	11
basis for dsrna	11
plays a crucial	11
needs to be	11
is composed of	11
the case for	11
activate and propagate	11
of ifn genes	11
rna viruses such	11
as a consequence	11
is a common	11
of the situation	11
into the cytosol	11
in the cns	11
central nervous system	11
evades host restriction	11
of the tlr	11
the translocation of	11
of cytokines and	11
propagate antiviral innate	11
course of infection	11
could not be	11
restriction by ifit	11
and propagate antiviral	11
under positive selection	11
adaptor inducing ifn	11
activation of ikk	11
previous studies have	11
like aggregates to	11
detected by the	11
in the first	11
role in regulating	11
may contribute to	11
habjan et al	11
was purchased from	11
important to note	11
rna helicase domain	11
high levels of	11
t cell responses	11
in influenza a	11
mavs forms functional	11
been linked to	11
used as a	11
differentiation primary response	11
proteins such as	11
a reduction in	11
binding protein that	11
induced expression of	11
required for rig	11
syncytial virus ns	11
to avoid rig	11
of h n	11
were immunoprecipitated with	11
domain and a	11
the text belongs	11
the same time	11
insights into rna	11
data not shown	11
response to poly	11
nonstructural protein a	11
is required to	11
ifn signaling pathway	11
the mechanisms of	11
in the viral	11
in an atp	11
were collected from	11
at least three	11
and antiviral signal	11
observing the word	11
v proteins of	11
recognition and innate	11
recognition and activation	11
i ifns in	11
the top words	11
g allele of	11
role of trim	11
and mda in	11
the ebola virus	11
by inhibition of	11
shown in figure	11
on the expression	11
the trim family	11
cap evades host	11
viral evasion of	11
was responsible for	11
of the meaning	11
like receptors in	11
systemic lupus erythematosus	11
of dexd h	11
have been found	11
the presence or	11
the actin cytoskeleton	11
to be activated	11
mrna cap evades	11
rna interference in	11
induced by ifn	11
a result of	11
kumar et al	11
cpg motifs in	11
to the induction	11
in accordance with	11
in hcv replication	11
the molecular mechanism	11
recruited to the	11
of viral rnas	11
prrsv n protein	11
coronavirus m protein	11
viruses to avoid	11
unusual viral rna	11
in the lung	11
at room temperature	11
of the manuscript	11
to promote viral	11
upon infection with	11
in antiviral defense	11
of which are	11
activation of protein	11
sendai virus c	11
upon rsv infection	11
in uninfected cells	11
the iav control	11
to form an	11
immune system is	11
the endosomal compartment	11
rnase l pathway	11
acids by retinoic	11
order rna structures	11
role of mda	11
for the first	11
resulted in the	11
differences in the	11
play important roles	11
reveals a signaling	11
by acting as	11
involvement of the	11
viruses can also	11
acting on rna	11
we demonstrated that	10
by a viral	10
of a variety	10
with clustalw implemented	10
detects cytosolic dna	10
and contributes to	10
in the rna	10
of the mechanisms	10
are presented in	10
from ensembl and	10
ifn production is	10
a strategy of	10
reveals a novel	10
lymphocytic choriomeningitis virus	10
from observing the	10
the molecular level	10
mrna dependent on	10
indicated that the	10
is an e	10
acid and encephalomyocarditis	10
is interesting to	10
ns interacts with	10
contrast to the	10
mechanism of action	10
role of trims	10
or b c	10
as a signal	10
transcriptional activation of	10
an moi of	10
not belong to	10
processing of genome	10
in the lsc	10
not affected by	10
ns protein in	10
dependent sensing of	10
after viral infection	10
a cytosolic dna	10
acts as an	10
domain is the	10
host immune responses	10
immune recognition of	10
tank binding kinase	10
expression of cytokines	10
inhibits the activation	10
which is an	10
factor activation by	10
regulate the expression	10
adaptor that facilitates	10
represented by a	10
sun et al	10
authors declare no	10
mechanism for the	10
a is a	10
the virus replication	10
indicate that the	10
of the mavs	10
and ncbi databases	10
cytokine production in	10
hcv rna replication	10
and stress granules	10
by inhibiting the	10
levels of the	10
in a similar	10
upon recognition of	10
the form of	10
ns a cleaves	10
signal transduction by	10
is mediated through	10
effect on the	10
the sars coronavirus	10
may be a	10
rna structures generated	10
the initiation of	10
and encephalomyocarditis picornavirus	10
inhibition of irf	10
the mitochondria to	10
the adaptor mavs	10
may be due	10
in the toll	10
i interferons through	10
nuclear factor kappa	10
of pkr by	10
to avoid the	10
such as rig	10
the dengue virus	10
deletion in the	10
can be considered	10
stimulated gene factor	10
to those of	10
the three rlr	10
liu et al	10
generated during virus	10
interferon signaling pathway	10
into rna recognition	10
trim and trim	10
inhibition of virus	10
and m j	10
melanoma differentiation associated	10
card domains and	10
likely to be	10
the respiratory tract	10
is expected to	10
depend on the	10
card and rd	10
of the hcv	10
immune responses against	10
the signaling pathways	10
recognition receptor rig	10
is dispensable for	10
gene expression in	10
kappab by toll	10
signaling by rna	10
version of the	10
of mitochondrial antiviral	10
to trigger ifn	10
of inflammatory cytokines	10
in human monocytes	10
of eif a	10
polymerase iii detects	10
signature for the	10
proteins interact with	10
infected a cells	10
some of these	10
in a sequence	10
can lead to	10
provides a molecular	10
riplet and trim	10
termini as a	10
stimulated with ifn	10
immunoprecipitated with anti	10
influenza virus and	10
of irf activation	10
shown in fig	10
of the c	10
dna and induces	10
of virus infection	10
it has also	10
the combination of	10
the establishment of	10
and activation by	10
loss of rig	10
myeloid immune cells	10
of nuclear factor	10
has shown that	10
transcription of ifn	10
also able to	10
response to virus	10
marq et al	10
lund et al	10
of viruses and	10
site model a	10
essential component of	10
the attachment of	10
mediated antiviral immunity	10
also been reported	10
transcription factor irf	10
a complex with	10
like receptor in	10
and proteasomal degradation	10
activation of a	10
has not yet	10
responses to polyriboinosinic	10
one or two	10
a platform for	10
sensing mechanism of	10
interactions with the	10
the ctd and	10
there is a	10
lysates were immunoprecipitated	10
identification of a	10
to identify the	10
mutations in the	10
a signaling cascade	10
ability of the	10
of the dsrna	10
may not be	10
the probability that	10
mediated antiviral signal	10
drv or b	10
infected with svv	10
a regulator of	10
the effects of	10
the study of	10
collected from ensembl	10
proteins encoded by	10
gene expression and	10
iii detects cytosolic	10
the surface of	10
and viral infection	10
of innate and	10
ube l and	10
for the top	10
induction of innate	10
is a target	10
which is required	10
analysis revealed that	10
interferons through the	10
syndrome coronavirus m	10
mda signaling by	10
xu et al	10
to the mitochondrial	10
were able to	10
are required to	10
trim family proteins	10
regulation of rlr	10
in immune cells	10
production by interfering	10
essential role in	10
domains of the	10
the innate immunity	10
antiviral defense and	10
interact with mavs	10
which is essential	10
in the field	10
clustalw implemented in	10
host defense against	10
and jev infection	10
polyubiquitination of rig	10
h n viruses	10
it is well	10
negatively regulates tlr	10
was found that	10
regulation of type	10
i and sting	10
molecular signature for	10
baum et al	10
c virus nonstructural	10
role for the	10
have evolved to	10
j and m	10
all of which	10
be associated with	10
the exact mechanism	10
used in this	10
for the treatment	10
w j in	10
during influenza virus	10
the viral ns	10
i detects viral	10
required for its	10
response to rna	10
in the last	10
ensembl and ncbi	10
influenza virus ns	10
regions of the	10
wu et al	10
derived dendritic cells	10
in these cells	10
antiviral immunity and	10
it was reported	10
and negative regulation	10
chiu et al	10
implemented in bioedit	10
the results of	10
essential components of	10
studies have demonstrated	10
honda et al	10
infected cells by	10
aligned with clustalw	10
ubiquitination and deubiquitination	10
box rna helicases	10
with the rig	10
which results in	10
antiviral response is	10
and rnase l	10
mechanism through which	10
been proposed that	10
i recognition of	10
cui et al	10
been observed in	10
activation by mda	10
a direct interaction	10
be considered as	10
are found in	10
nucleic acid sensing	10
in this way	10
a negative feedback	10
is also involved	10
a large number	10
polyribocytidylic acid and	10
mediated by rig	10
blood mononuclear cells	10
mice infected with	10
at an moi	10
several studies have	10
a dexd h	10
through the rig	10
and ns a	10
for induction of	10
it is interesting	10
of porcine reproductive	10
each word is	10
phosphorylation and activation	10
to the ifn	10
the endolysosomal compartment	10
the retinoic acid	10
disruption of the	10
the unfolded protein	10
role in innate	10
amino acid sequence	10
antagonize type i	10
an essential component	10
unmethylated cpg motifs	10
pi k akt	10
it remains to	10
irf activation by	10
patients with chronic	10
interferon pathway by	10
in some cases	10
the indicated antibodies	10
is based on	10
in the present	10
swine fever virus	10
it should be	10
release of the	10
the phosphatase pp	10
which is also	10
is a potent	10
data indicate that	10
of host proteins	10
to hepatitis c	10
syndrome coronavirus nsp	10
with the host	10
illustrated by the	10
to elucidate the	10
and signal transduction	9
like receptor activation	9
and figure s	9
role of rnase	9
it is unclear	9
i ifn pathway	9
was able to	9
the requirement for	9
has been observed	9
activation of p	9
by rnase l	9
to the cell	9
the ns b	9
i and the	9
as a positive	9
the most important	9
modulates type i	9
foreign nucleic acid	9
through the induction	9
and effector functions	9
response in the	9
i ifn receptor	9
deaminase acting on	9
and as a	9
off the mitochondria	9
distribution or reproduction	9
induce the formation	9
induction during the	9
virus infection by	9
in viral infection	9
was associated with	9
suppression of innate	9
be necessary to	9
is noteworthy that	9
these viral proteins	9
rna binding proteins	9
were purchased from	9
of the family	9
play a critical	9
the family of	9
as an important	9
the nsd complex	9
ability to induce	9
stimulation of the	9
belonging to the	9
that has been	9
studies will be	9
are resistant to	9
innate immunity in	9
a range of	9
this is a	9
in regulating the	9
for degradation by	9
crucial for the	9
and control of	9
and innate antiviral	9
be used to	9
with type i	9
i to promote	9
with drv or	9
self nucleic acids	9
immunity induced by	9
indicate that ns	9
signaling protein off	9
and mda activates	9
due to their	9
positive regulation of	9
transcribed rna intermediate	9
in spite of	9
that of the	9
and aligned with	9
and expression of	9
change in the	9
of emcv and	9
inhibited by the	9
which binds to	9
inhibits the type	9
host response to	9
g bp and	9
innate immune pathways	9
in the release	9
sensor of rig	9
further studies are	9
in pathogen recognition	9
of the pathogen	9
receptors in the	9
factors such as	9
i has been	9
of the eif	9
each of these	9
or empty vector	9
deduced protein sequences	9
the antiviral rig	9
of trim with	9
the interaction with	9
innate immune activation	9
for the detection	9
evidence suggests that	9
sensing of poly	9
against rna viruses	9
stranded rna via	9
no conflict of	9
through inhibition of	9
dna sensing by	9
to provide a	9
identified in the	9
to be further	9
on the molecular	9
during iav infection	9
interaction of rig	9
the er to	9
of these genes	9
during infection with	9
response to viruses	9
the current study	9
as the reference	9
meylan et al	9
it was also	9
regions of zbrig	9
the emergence of	9
adenosine deaminase acting	9
for proteasomal degradation	9
the host cells	9
effect of the	9
production by targeting	9
stranded ribonucleic acids	9
with mavs and	9
zhong et al	9
to detect and	9
the ring domain	9
closely related to	9
referred to as	9
viral rna is	9
of interferon signaling	9
a gap or	9
well plates were	9
in the supernatants	9
and the helicase	9
basis for viral	9
the ubiquitin system	9
mda activates antiviral	9
one or more	9
i is a	9
viral innate immune	9
of ifn signaling	9
protein inhibits the	9
infected epithelial cells	9
rna by the	9
for interaction with	9
farrell et al	9
is the rna	9
by viral infection	9
genomic rna during	9
ifn antiviral activity	9
and evolution of	9
decrease in the	9
was proposed to	9
and induction of	9
in the future	9
peripheral blood mononuclear	9
self and nonself	9
b c at	9
host type i	9
of antiviral immunity	9
hcv ns a	9
of the infection	9
in the alignment	9
the reference sequence	9
by means of	9
study suggests that	9
be the case	9
virus protease ns	9
it is noteworthy	9
rna during negative	9
and inhibits the	9
synthesis of unanchored	9
the antiviral innate	9
host antiviral responses	9
a cap structure	9
gap or deletion	9
viral rna in	9
serves as an	9
the creative commons	9
sense rna viruses	9
i helicase and	9
regulation of gene	9
depends on the	9
the middle east	9
this results in	9
in the form	9
nucleotide polymorphisms of	9
of rna virus	9
conjugation to target	9
word is represented	9
this is an	9
induced oligomerization of	9
dependent type i	9
the capacity of	9
to block the	9
or deletion in	9
mouse embryonic fibroblasts	9
be recognized by	9
to investigate the	9
is not the	9
and ns b	9
located on the	9
in this context	9
double stranded rna	9
any of the	9
in the myd	9
interference in mammalian	9
binding of rig	9
of long double	9
detects viral genomic	9
is an endoplasmic	9
be targeted by	9
protein involved in	9
immune evasion by	9
mediated antiviral innate	9
the supernatants of	9
remain to be	9
is recruited to	9
ikkepsilon and tbk	9
transfected with the	9
interferon stimulated gene	9
transcription and translation	9
i and ii	9
to promote interferon	9
small interfering rnas	9
by the fact	9
e ligase trim	9
on type i	9
by plasmacytoid dendritic	9
outside of the	9
huang et al	9
ubiquitin ligase activity	9
species were collected	9
i signaling pathway	9
was dependent on	9
cells such as	9
cells via the	9
of middle east	9
was confirmed by	9
borna disease virus	9
of downstream signaling	9
and interferon antagonism	9
membrane association and	9
virus infection the	9
higher levels of	9
of the respiratory	9
leading to a	9
represents the same	9
structures generated during	9
in the intracellular	9
regulatory domain is	9
to be an	9
mass spectrometry analysis	9
protein off the	9
in recent years	9
c virus protease	9
mammalian species were	9
triphosphate sensor of	9
of the indicated	9
stimulator of ifn	9
in the er	9
was also found	9
the ctd of	9
the nuclear translocation	9
results demonstrate that	9
immune cells and	9
was performed using	9
methylation provides a	9
is known about	9
positive strand rna	9
of unanchored k	9
reference sequence of	9
of host immune	9
to contribute to	9
directly or indirectly	9
cells were incubated	9
detection of foreign	9
many of the	9
in the cells	9
infected cells were	9
mechanisms used by	9
results indicated that	9
to the identification	9
immunodeficiency virus type	9
viruses have developed	9
protease domain of	9
proteins and their	9
been described as	9
to evade the	9
viruses in innate	9
variant allele of	9
terminal regulatory domain	9
as mentioned above	9
been demonstrated that	9
implications for the	9
the nucleus where	9
the nuclear factor	9
mitochondria to evade	9
that leads to	9
trim and rig	9
and dengue virus	9
the plasma membrane	9
suppresses type i	9
c virus core	9
innate immunity induced	9
viral rna sensing	9
a cleaves mitochondrial	9
card domain of	9
are expressed in	9
jak stat signaling	9
recognition of hepatitis	9
ifn signaling pathways	9
are critical for	9
interacts with traf	9
of translation initiation	9
was determined by	9
like receptor lgp	9
to viral rna	9
cells were treated	9
the secretion of	9
viral infection is	9
murine hepatitis virus	9
effectors of the	9
well as in	9
ligase activity of	9
mediated ubiquitination of	9
for viral rna	9
by the rig	9
to the viral	9
cleaves mitochondrial antiviral	9
proteins ns and	9
inhibition of type	9
helicase and activation	9
gene induction by	9
evidence for the	9
be able to	9
a viral deubiquitinase	9
and b cells	9
ubiquitin and ubiquitin	9
similar to that	9
an rna polymerase	9
strategy of negative	9
interesting to note	9
the rna exosome	9
considered to be	9
used in the	9
induced proteins with	9
a distinct role	9
nod and nod	9
sequence of human	9
cytoplasmic viral rna	9
bronchial epithelial cells	9
rna and inhibits	9
adaptor protein trif	9
is a critical	9
viral proteins and	9
filaments in an	9
rna replication and	9
cov orf b	9
of interferon genes	9
inhibitor of the	9
regulation of ifn	9
rd regions of	9
the restriction of	9
of the receptor	9
triggered type i	9
i repressor domain	9
the corresponding category	9
oligomerization of the	9
dependent interferon induction	9
antiviral response to	9
signal transduction pathways	9
c k and	9
will focus on	9
detected in the	9
was observed in	8
i for k	8
occurs in the	8
cell lines and	8
and k of	8
the linker region	8
containing the word	8
representation of the	8
in the lungs	8
viruses and the	8
and antiviral signaling	8
the results showed	8
viruses in the	8
a broad range	8
of the mitochondrial	8
molecules such as	8
involved in ifn	8
activation in response	8
activation by innate	8
in nucleic acid	8
that there are	8
cytokines such as	8
is likely to	8
of stat and	8
of the duck	8
dimerization and nuclear	8
as a vector	8
transcription factor activation	8
in human antiviral	8
t cells in	8
adenosine deaminase adar	8
host protein synthesis	8
of traf in	8
the c pro	8
absence of a	8
the c terminus	8
and severe acute	8
that in the	8