quadgram

This is a table of type quadgram and their frequencies. Use it to search & browse the list to learn more about your study carrel.

quadgram	frequency
severe acute respiratory syndrome	2520
in the presence of	1800
acute respiratory syndrome coronavirus	1527
in the absence of	1118
in the case of	955
has been shown to	886
on the other hand	851
for the treatment of	815
of hepatitis c virus	799
as well as the	779
for the detection of	772
middle east respiratory syndrome	755
of severe acute respiratory	748
in the context of	713
in vitro and in	690
porcine reproductive and respiratory	683
reproductive and respiratory syndrome	678
vitro and in vivo	619
and respiratory syndrome virus	607
have been shown to	606
the end of the	596
an important role in	593
east respiratory syndrome coronavirus	560
human immunodeficiency virus type	556
one of the most	541
was found to be	533
is one of the	529
medrxiv a license to	502
a license to display	502
to display the preprint	502
has granted medrxiv a	502
granted medrxiv a license	502
who has granted medrxiv	502
license to display the	502
display the preprint in	502
can be used to	482
is the author funder	473
at the end of	473
been shown to be	471
copyright holder for this	464
the copyright holder for	464
of the viral genome	457
play a role in	450
in the treatment of	443
the preprint in perpetuity	441
a wide range of	434
for the development of	428
the aim of this	428
as a result of	426
of mouse hepatitis virus	425
it has been shown	418
of this study was	417
in addition to the	413
in the present study	403
the presence of a	402
the presence of the	401
this study was to	399
the severe acute respiratory	398
on the basis of	395
european food safety authority	390
the european food safety	389
a large number of	385
aim of this study	377
in the regulation of	373
it is possible that	365
it is important to	365
were found to be	365
holder for this preprint	360
on the surface of	349
has been shown that	347
cells were infected with	340
at the same time	335
was used as a	318
the structure of the	316
at the time of	316
preprint this version posted	315
studies have shown that	315
for this preprint this	315
this preprint this version	315
the hepatitis c virus	314
in the united states	309
play an important role	308
these results suggest that	306
as well as in	305
for the first time	305
in the development of	304
this work was supported	297
of the viral rna	296
of human immunodeficiency virus	296
it is made available	289
international license it is	288
hepatitis c virus rna	288
made available under a	288
license it is made	288
is made available under	288
rna was extracted from	286
to be involved in	285
for the presence of	280
certified by peer review	280
work was supported by	280
of porcine reproductive and	280
not certified by peer	280
was not certified by	279
a member of the	278
the innate immune response	278
used in this study	277
a is the author	272
available under a is	272
under a is the	272
the formation of the	267
similar to that of	266
the role of the	261
plays an important role	259
which was not certified	258
porcine epidemic diarrhea virus	256
as shown in fig	254
in the formation of	253
the expression of the	253
the central nervous system	251
in the pathogenesis of	250
the crystal structure of	248
in contrast to the	248
it was shown that	246
a role in the	244
presence or absence of	236
the total number of	235
important role in the	234
of influenza a virus	233
it is likely that	232
the context of a	232
cells were transfected with	230
we were able to	229
acute respiratory distress syndrome	228
to the development of	227
crystal structure of the	226
it is possible to	226
with severe acute respiratory	224
we found that the	221
in cells infected with	220
cells were treated with	219
hepatitis c virus replication	218
r n a l	217
p r o o	216
o u r n	216
u r n a	216
a l p r	216
n a l p	216
j o u r	216
l p r e	216
r o o f	216
a key role in	215
the antiviral activity of	214
has been carried out	214
hepatitis c virus infection	213
was added to the	213
aim of the study	213
it was found that	213
to that of the	213
the surface of the	212
as shown in figure	212
of viral rna in	211
herpes simplex virus type	211
the size of the	209
has been reported to	208
in the form of	208
it has been reported	208
with the exception of	207
the presence or absence	207
be considered as an	207
it may not be	205
was shown to be	204
is based on the	204
identification and characterization of	204
the viral life cycle	204
not be considered as	203
as well as a	203
these results indicate that	202
of hepatitis b virus	201
in the number of	199
plays a role in	197
is involved in the	196
these data suggest that	195
of a novel coronavirus	195
as regards the issues	194
and the conclusions reached	194
reached in the present	194
addressed and the conclusions	194
view and position as	194
and position as regards	194
the conclusions reached in	194
in the present document	194
safety authority reserves its	194
may not be considered	194
position as regards the	194
food safety authority reserves	194
the issues addressed and	194
authority reserves its rights	194
regards the issues addressed	194
issues addressed and the	194
conclusions reached in the	194
awarded following a tender	193
a contract between the	193
published complying with the	193
adopted by the authority	193
to which the authority	193
this task has been	193
food safety authority and	193
considered as an output	193
principle to which the	193
document is published complying	193
the present document is	193
carried out exclusively by	193
as an output adopted	193
safety authority and the	193
following a tender procedure	193
transparency principle to which	193
out exclusively by the	193
the authority is subject	193
task has been carried	193
which the authority is	193
the transparency principle to	193
of a contract between	193
output adopted by the	193
an output adopted by	193
between the european food	193
context of a contract	193
with the transparency principle	193
complying with the transparency	193
been carried out exclusively	193
present document is published	193
is published complying with	193
contract between the european	193
it has been suggested	192
are involved in the	190
end of the genome	189
the ability of the	189
has been reported that	188
of herpes simplex virus	188
of this study is	187
by the presence of	187
in a mouse model	187
in this study we	186
the rights of the	186
be involved in the	186
avian infectious bronchitis virus	186
without prejudice to the	185
hepatitis c virus ns	185
the innate immune system	185
to the rights of	185
prejudice to the rights	185
by the bodies identified	184
and adopted by the	184
produced and adopted by	184
has been produced and	184
been produced and adopted	184
present document has been	184
the present document has	184
adopted by the bodies	184
the bodies identified above	184
bodies identified above as	184
document has been produced	184
internal ribosome entry site	183
as a function of	182
the length of the	181
at an moi of	180
coronavirus infectious bronchitis virus	179
it should be noted	179
was supported by the	177
the formation of a	176
to the formation of	176
of west nile virus	176
the nature of the	176
peripheral blood mononuclear cells	176
is consistent with the	176
disease control and prevention	176
the development of a	176
at the level of	176
the majority of the	174
our understanding of the	174
can be used for	174
has been suggested that	174
of the hepatitis c	174
a wide variety of	173
to the presence of	173
the results of the	173
of the innate immune	173
the activation of the	171
with respect to the	170
is responsible for the	170
by the authors in	169
may be due to	169
authority and the authors	168
exclusively by the authors	168
the authors in the	168
should be noted that	168
authors in the context	168
a critical role in	168
during the course of	167
for disease control and	167
identified above as authors	167
rights of the authors	167
was performed using the	166
the expression levels of	166
for the production of	166
the world health organization	166
this is the first	165
little is known about	165
the specificity of the	165
to be associated with	164
of type i ifn	162
under the control of	162
of middle east respiratory	162
have been reported to	161
the sequence of the	161
a crucial role in	161
in the production of	161
this study is to	160
can be used as	160
of vesicular stomatitis virus	159
of the immune system	159
has been used to	158
total rna was extracted	158
as compared to the	158
be used as a	158
at room temperature for	158
in the course of	157
was detected in the	156
in a variety of	156
by the addition of	156
for the synthesis of	155
a broad range of	155
the aim of the	154
in patients with severe	154
bovine viral diarrhea virus	153
the use of a	153
the function of the	152
an increase in the	152
the fact that the	152
in the cytoplasm of	151
structure and function of	151
is required for the	151
there was no significant	151
be due to the	151
as a template for	149
the results showed that	149
have shown that the	149
the use of the	148
isolation and characterization of	148
have been used to	146
that can be used	146
of the n protein	146
international committee on taxonomy	145
the limit of detection	145
rna was detected in	145
of the virus in	145
of feline infectious peritonitis	145
mechanism of action of	144
the case of the	144
committee on taxonomy of	143
rift valley fever virus	142
national institutes of health	142
a major role in	142
of the sars coronavirus	142
the rest of the	142
the active site of	142
a final concentration of	142
also been shown to	141
we have shown that	141
patients with chronic hepatitis	140
of hepatitis e virus	140
a better understanding of	140
in the presence or	140
and the number of	140
in vivo and in	140
can be found in	139
may play a role	139
venezuelan equine encephalitis virus	138
is known about the	138
the authors declare no	138
been found to be	138
centers for disease control	138
the activity of the	138
have been found to	138
for the study of	137
the treatment of covid	137
classical swine fever virus	137
the molecular biology of	137
is essential for the	137
has not yet been	136
it has also been	136
it is known that	136
the stability of the	136
the human immunodeficiency virus	136
for the diagnosis of	136
for each of the	135
vivo and in vitro	135
of the host cell	135
influenza a and b	135
feline infectious peritonitis virus	135
no conflict of interest	135
the purpose of this	134
one of the major	134
in the expression of	134
results suggest that the	134
on taxonomy of viruses	133
the international committee on	133
is thought to be	133
the effect of the	133
is not required for	133
the sensitivity of the	133
as part of the	132
of the genomic rna	132
no reuse allowed without	131
in patients with covid	131
reuse allowed without permission	131
the mechanism by which	131
our results suggest that	130
the beginning of the	130
were detected in the	130
with the use of	130
in the field of	130
the authors declare that	130
has been found to	129
h n influenza virus	129
and characterization of a	129
of type i interferon	128
have been identified in	128
min at room temperature	128
the unfolded protein response	127
is a member of	127
in the process of	127
coronavirus mouse hepatitis virus	127
identification of a novel	126
to determine whether the	126
was observed in the	126
the context of the	126
for the identification of	126
has the potential to	126
both in vitro and	126
as a consequence of	126
the causative agent of	125
an essential role in	125
no significant difference in	125
the type i interferon	125
it has been proposed	125
the importance of the	124
studies are needed to	124
orf a and orf	124
may be involved in	123
have the potential to	123
is associated with the	123
used to determine the	123
our results show that	123
the mechanism of action	123
was used as the	123
congo hemorrhagic fever virus	123
had no effect on	123
are likely to be	121
as well as to	121
of respiratory syncytial virus	121
are known to be	121
hepatitis c virus core	121
the replication of the	121
would like to thank	121
is likely to be	120
better understanding of the	120
nucleotide sequence of the	120
to the lack of	120
cd and cd t	120
the antiviral effect of	120
rna dependent rna polymerase	120
for hepatitis c virus	119
has also been shown	119
the basis of the	119
has also been reported	119
the nucleocapsid protein of	119
a high degree of	119
that there is a	119
influenza a h n	118
these data indicate that	118
by the fact that	118
than that of the	118
of the severe acute	118
on the use of	118
as well as for	118
other members of the	117
the presence of an	117
it has been demonstrated	117
results indicate that the	117
the development of new	117
a mouse model of	117
analysis was performed using	116
been reported to be	116
efficacy and safety of	116
in the control of	116
a small number of	116
is known to be	116
higher than that of	116
vascular endothelial growth factor	116
for min at room	115
it remains to be	115
with chronic hepatitis c	115
of the virus to	115
may contribute to the	115
the control of the	114
c virus rna replication	114
was carried out using	114
the life cycle of	114
the course of the	113
the vast majority of	113
and the presence of	113
the early stages of	113
remains to be determined	113
at the beginning of	113
a significant increase in	113
rna was isolated from	113
detection of viral rna	113
the absence of a	112
of the human genome	112
the presence of viral	112
it is not clear	112
the interaction between the	112
has been associated with	112
were included in the	112
in the range of	112
have been reported in	112
on the presence of	112
the analysis of the	112
it is clear that	112
for the generation of	111
a novel coronavirus from	111
pp a and pp	111
in agreement with the	111
of semliki forest virus	111
for the formation of	111
by hepatitis c virus	111
the secondary structure of	111
to interact with the	110
the present study was	110
the absence of the	110
has been proposed that	110
the detection of sars	110
on the cell surface	110
a potent inhibitor of	110
in this study were	110
when compared to the	110
of infectious bronchitis virus	109
the synthesis of the	109
respiratory syndrome coronavirus infection	109
can be detected in	109
to the plasma membrane	109
has been demonstrated that	109
sequence analysis of the	109
in hepatitis c virus	108
is dependent on the	108
of patients infected with	108
of the s protein	108
study was to investigate	108
of a variety of	107
a and orf b	107
innate and adaptive immune	107
is mediated by the	107
similar to those of	107
in the evolution of	107
that they have no	107
in any of the	107
in the current study	106
it is not known	106
to be able to	106
it is difficult to	106
the amino acid sequence	106
in a number of	106
was used for the	106
dna and rna viruses	106
important to note that	106
in the activation of	106
as a negative control	106
the influenza a virus	106
were observed in the	106
human respiratory syncytial virus	106
of the influenza virus	106
have been associated with	106
it is necessary to	106
of the most important	106
is important to note	106
that the presence of	105
characterization of a novel	105
due to the presence	105
as one of the	105
food and drug administration	105
were shown to be	105
play important roles in	105
plays a key role	105
of the immune response	105
in the active site	105
of viral rna synthesis	105
by the use of	105
was used to determine	105
involved in the regulation	104
viral rna mini kit	104
due to the lack	104
holder for this this	104
in patients with chronic	104
in vero e cells	104
the existence of a	104
this this version posted	104
viral rna in the	104
for this this version	104
and function of the	104
the development of the	103
the assembly of the	103
a and pp ab	103
in accordance with the	103
were added to the	103
a limited number of	103
of the present study	103
is possible that the	103
of murine hepatitis virus	103
results showed that the	103
declare that they have	103
at a concentration of	103
could be due to	103
our data suggest that	102
revealed the presence of	102
n and h n	101
regulation of gene expression	101
type i ifn production	101
to the fact that	101
patients with severe covid	101
h n and h	101
a result of the	101
these findings suggest that	101
associated with severe acute	101
purpose of this study	100
of the virus and	100
of a number of	100
the expression level of	100
have been found in	100
between the two groups	99
members of the family	99
transcription polymerase chain reaction	99
is required for efficient	99
were found in the	99
in an attempt to	99
study was to determine	99
in order to determine	98
the upper respiratory tract	98
we would like to	98
new insights into the	98
african swine fever virus	98
was no significant difference	98
structure of the rna	98
a decrease in the	97
followed by cycles of	97
have been detected in	97
were obtained from the	97
of the role of	97
the position of the	97
authors declare that they	97
incubated for h at	97
the quality of the	97
the binding of the	97
of the murine coronavirus	97
to the end of	97
end of the viral	97
with fetal bovine serum	96
the identification of the	96
was to investigate the	96
is supported by the	96
was performed using a	96
we have developed a	96
and the role of	96
declare no conflict of	96
in the replication of	96
studies have demonstrated that	96
and the development of	96
in the central nervous	96
our results indicate that	96
a broad spectrum of	95
are shown in fig	95
the molecular basis of	95
be explained by the	95
at the plasma membrane	95
authors declare no conflict	95
a significant reduction in	95
to play a role	95
h at room temperature	95
lower than that of	95
could be used to	95
dependent rna polymerase from	95
is due to the	94
complete genome sequence of	94
have not yet been	94
replication in cell culture	94
to those of the	94
in the genome of	94
was performed as described	94
the inhibitory effect of	94
of the genome of	94
is associated with a	93
the spread of the	93
is shown in fig	93
in the control group	93
to be the most	93
eukaryotic translation initiation factor	93
in the near future	93
complete nucleotide sequence of	92
of the international committee	92
structural basis for the	92
we have previously shown	92
be related to the	92
chronic obstructive pulmonary disease	92
viral rna was detected	92
a multiplicity of infection	92
the expression of a	92
innate immune response to	92
be responsible for the	91
no relationships to disclose	91
qiaamp viral rna mini	91
in comparison to the	91
has been proposed to	91
in the majority of	91
study was to evaluate	91
as described in the	91
and characterization of the	91
of type i ifns	91
a final volume of	90
the middle east respiratory	90
was not detected in	90
was approved by the	90
the results of this	90
was carried out in	90
a high level of	90
white spot syndrome virus	90
been shown that the	90
in the human genome	90
mouse hepatitis virus strain	90
plays a critical role	90
samples were collected from	90
to the production of	90
c virus core protein	90
spread of the virus	90
data suggest that the	89
the interaction of the	89
in the respiratory tract	89
of influenza a viruses	89
were significantly higher in	89
closely related to the	89
systematic review and meta	89
did not show any	89
and cd t cells	89
type i and type	89
are summarized in table	88
to a lesser extent	88
the genome of the	88
of tobacco mosaic virus	88
in response to the	88
of the most common	88
detection and quantification of	88
the detection of the	88
by western blot analysis	88
the presence of sars	88
respiratory syncytial virus infection	88
for the design of	88
has been observed in	88
patients with severe acute	88
the host immune response	87
cells were incubated with	87
to better understand the	87
appears to be a	87
this is consistent with	87
washed three times with	87
has been identified as	87
is present in the	87
in terms of the	87
is not essential for	87
supplemented with fetal bovine	87
g for min at	86
from patients with pneumonia	86
is similar to that	86
one of the main	86
amino acid sequence of	86
could be detected in	86
were used for the	86
can be divided into	86
in the viral genome	86
in the detection of	86
of hepatitis a virus	86
hepatitis virus strain a	86
the early phase of	86
of gene expression in	86
was found in the	85
the early stage of	85
to the cell surface	85
that are involved in	85
of hospitalized patients with	85
after the onset of	85
is considered to be	85
can be used in	85
is the most common	84
are shown in table	84
has been demonstrated to	84
has been implicated in	84
sensitivity and specificity of	84
have been developed to	84
amino acid sequences of	84
was to evaluate the	84
it is also possible	84
tomato bushy stunt virus	84
our results showed that	84
in close proximity to	84
to bind to the	84
the molecular mechanisms of	84
play a key role	84
of cd t cells	83
mutational analysis of the	83
in relation to the	83
as a positive control	83
for the expression of	83
compared to that of	83
with hepatitis c virus	83
the release of the	83
in viral rna synthesis	83
to the use of	83
on the role of	83
of an rna virus	83
are listed in table	83
origin and evolution of	82
of the study was	82
cells infected with the	82
the study of the	82
article is protected by	82
for the use of	82
we show that the	82
the lack of a	82
levels of viral rna	82
is protected by copyright	82
hospitalized patients with covid	82
the virus life cycle	82
a central role in	82
on the expression of	82
are shown in figure	82
compared to the control	82
this article is protected	82
for the control of	81
been shown to play	81
the effects of the	81
blood samples were collected	81
and hepatitis c virus	81
at different time points	81
was significantly higher in	81
in cell culture and	81
for the analysis of	81
shown to interact with	81
at a multiplicity of	81
has led to the	81
total rna was isolated	81
be used for the	80
have a role in	80
the performance of the	80
to be important for	80
and the cells were	80
in order to identify	80
have been implicated in	80
the aim of our	80
for h at room	80
in the management of	80
respiratory syndrome coronavirus nsp	80
in cells transfected with	80
of the presence of	80
on the one hand	79
is related to the	79
the course of infection	79
secondary structure of the	79
similar results were obtained	79
rna and dna viruses	79
it was observed that	79
as well as other	79
a pivotal role in	78
and the use of	78
for the replication of	78
of newcastle disease virus	78
reverse transcription polymerase chain	78
to be essential for	78
the location of the	78
it is interesting to	78
did not affect the	78
no significant differences in	78
the inhibition of the	78
using a combination of	78
in an in vitro	78
in view of the	78
was added to each	78
studies are required to	78
viral rna was extracted	78
have been identified as	77
this suggests that the	77
the herpes simplex virus	77
previous studies have shown	77
with the help of	77
to the identification of	77
of the number of	77
was to determine the	77
study was supported by	77
have previously shown that	77
structure of the sars	77
that most of the	77
these results demonstrate that	77
but not in the	77
in the synthesis of	77
preprint the copyright holder	77
a component of the	77
in the induction of	77
at the university of	77
highly pathogenic avian influenza	77
the development of novel	77
to be responsible for	76
into the host cell	76
of viral rna and	76
coronavirus associated with severe	76
the relationship between the	76
in each of the	76
may be related to	76
are present in the	76
of japanese encephalitis virus	76
of each of the	76
type i interferon response	76
shown in figure a	76
a total of patients	76
are responsible for the	76
the west nile virus	76
the detection of viral	76
the coronavirus mouse hepatitis	76
it is noteworthy that	76
was extracted from the	76
the regulation of the	76
and middle east respiratory	75
the coronavirus infectious bronchitis	75
novel coronavirus associated with	75
been shown to have	75
of interferon regulatory factor	75
the evolution of the	75
of the dengue virus	75
comparable to that of	75
there is no evidence	75
in line with the	75
of the novel coronavirus	75
in the nucleus and	75
members of the genus	75
for rapid detection of	75
cells as well as	75
and functional analysis of	75
h n influenza a	75
detection of novel coronavirus	75
well as in the	75
the mechanisms by which	75
the possibility that the	75
results show that the	75
play a crucial role	75
has been detected in	74
this version posted september	74
of the m protein	74
of the spike protein	74
the study was to	74
to investigate the effect	74
investigate the effect of	74
the origin of the	74
have no competing interests	74
and it has been	74
were identified in the	74
in the vicinity of	74
of patients with covid	74
cells were cultured in	74
can also be used	74
a novel coronavirus associated	74
at the cell surface	74
in addition to its	74
rna viruses such as	74
of the nucleic acid	74
h n influenza viruses	74
crystal structure of a	74
c virus ns a	74
the potential role of	74
the spike protein of	73
alone or in combination	73
there was a significant	73
the structure and function	73
and is associated with	73
of avian infectious bronchitis	73
may be associated with	73
the cells were washed	73
as well as by	73
it is thought that	73
in the design of	73
one of the two	73
is important for the	73
the untranslated region of	73
in the host cell	73
with the presence of	73
and adaptive immune responses	73
is supported by a	73
the objective of this	73
internal ribosomal entry site	73
in the viral life	73
kindly provided by dr	73
in vitro transcribed rna	73
the best of our	72
to the best of	72
shown to be a	72
key role in the	72
may serve as a	72
both dna and rna	72
the efficiency of the	72
are thought to be	72
a systematic review and	72
that the expression of	72
best of our knowledge	72
is part of the	72
does not appear to	72
in order to investigate	72
of the cell cycle	72
is believed to be	72
and is required for	72
they have no competing	72
there is evidence that	72
figure a and b	72
incubated for min at	72
outbreak associated with a	72
in the endoplasmic reticulum	72
used as a template	72
hek t cells were	72
foot and mouth disease	72
it is believed that	72
there were no significant	72
be one of the	72
of the type i	72
untranslated region of the	71
which is consistent with	71
to the activation of	71
associated with a new	71
the viral genome and	71
in viral replication and	71
the identity of the	71
over a period of	71
of the genome and	71
type i interferon production	71
it was reported that	71
assay for detection of	71
hepatitis c virus in	71
supported in part by	71
plays a crucial role	71
that the majority of	71
a functional receptor for	71
the impact of the	71
in spite of the	71
in the generation of	71
at the site of	71
the s protein of	71
as the number of	71
a part of the	71
has yet to be	71
increase in the number	71
for severe acute respiratory	71
one of the first	71
a retrospective cohort study	71
of the central nervous	71
is shown in figure	71
by agarose gel electrophoresis	71
terminal domain of the	70
a new coronavirus of	70
for their ability to	70
version of this article	70
in a recent study	70
viral rna synthesis and	70
the national institutes of	70
with the development of	70
this version posted august	70
with a new coronavirus	70
that the number of	70
pneumonia outbreak associated with	70
epidermal growth factor receptor	70
a pneumonia outbreak associated	70
in the present work	70
west nile virus infection	70
in order to evaluate	70
the integrity of the	70
see materials and methods	70
did not result in	70
new coronavirus of probable	70
a significant decrease in	70
included in this study	70
the first time that	70
of probable bat origin	70
to be required for	70
coronavirus of probable bat	70
cells were seeded in	70
crucial role in the	70
are consistent with the	69
the results show that	69
production of type i	69
regulate the expression of	69
in influenza a virus	69
play a critical role	69
cells were grown in	69
room temperature for min	69
a significant role in	69
for up to days	69
in the assembly of	69
a major cause of	69
it was demonstrated that	69
for viral replication and	69
be found in the	69
was obtained from the	69
was reported to be	69
is similar to the	69
referred to as the	69
of genes involved in	69
for a total of	69
functional analysis of the	69
for the detection and	69
is located in the	69
role in the regulation	69
to the discovery of	69
cells were fixed with	68
with regard to jurisdictional	68
the large number of	68
maps and institutional affiliations	68
springer nature remains neutral	68
remains neutral with regard	68
was carried out by	68
is closely related to	68
nature remains neutral with	68
in a patient with	68
in chronic hepatitis c	68
have also been reported	68
at least in part	68
inhibit the replication of	68
in the genomes of	68
neutral with regard to	68
of the viral life	68
regard to jurisdictional claims	68
of the h n	68
by in vitro transcription	68
prevention and treatment of	68
viral rna replication and	68
the start of the	68
performed as previously described	68
and severe acute respiratory	68
response to viral infection	68
the results suggest that	68
required for viral replication	68
mitochondrial antiviral signaling protein	67
published maps and institutional	67
were used in the	67
was significantly higher than	67
in published maps and	67
our aim was to	67
to jurisdictional claims in	67
cells transfected with the	67
claims in published maps	67
influenza a virus infection	67
phylogenetic analysis of the	67
jurisdictional claims in published	67
due to the high	67
this version posted june	67
the polymerase chain reaction	67
despite the fact that	67
a new class of	67
the viral genomic rna	67
in the level of	67
of the nucleocapsid protein	66
safety and efficacy of	66
of dna and rna	66
of viral rna replication	66
the absence of any	66
an increasing number of	66
were performed using the	66
infected with novel coronavirus	66
the type i ifn	66
as well as with	66
in an effort to	66
clinical features of patients	66
were washed three times	66
of the creative commons	66
the immune response to	66
the creative commons attribution	66
been shown to inhibit	66
distributed under the terms	66
an equal volume of	66
objective of this study	66
in this work we	66
a single amino acid	66
of one of the	66
the onset of symptoms	66
the average number of	66
at a dose of	66
molecular biology of coronaviruses	66
has been reported in	66
to determine if the	66
further studies are needed	66
for the inhibition of	66
the host response to	65
is yet to be	65
and can be used	65
the s ribosomal subunit	65
blood and blood products	65
patients with pneumonia in	65
the efficacy and safety	65
that the use of	65
the open reading frame	65
response to virus infection	65
the viral replication cycle	65
we are grateful to	65
the largest rna virus	65
the cytoplasm of infected	65
ns a and ns	65
due to the fact	65
the synthesis of a	65
national center for biotechnology	65
of the plasma membrane	65
are one of the	65
to a final concentration	65
coronavirus from patients with	65
in the lungs of	65
for the majority of	65
as well as their	65
in the recognition of	65
cd t cell responses	65
to the number of	65
a consequence of the	65
have been observed in	65
novel coronavirus from patients	65
of small interfering rna	65
interesting to note that	65
in most of the	65
of our study was	65
the number of reads	65
of viral nucleic acids	65
in cells treated with	65
on the day of	64
the s and s	64
in the study of	64
different regions of the	64
of reactive oxygen species	64
the genome sequence of	64
a novel coronavirus in	64
report of the international	64
by polymerase chain reaction	64
at room temperature and	64
be noted that the	64
the production of infectious	64
significant difference in the	64
to note that the	64
the national institute of	64
were carried out in	64
of classical swine fever	64
the middle of the	64
respiratory syndrome coronavirus in	64
in the last years	64
the nucleotide sequence of	64
with pneumonia in china	64
is also possible that	64
nucleotide and amino acid	64
be detected in the	64
have been developed for	64
aim of our study	64
the virus in the	64
this study was supported	64
limit of detection of	64
positive strand rna viruses	63
of porcine epidemic diarrhea	63
the determination of the	63
role in the pathogenesis	63
of the in vitro	63
the viral rna genome	63
it is well known	63
of the amino acid	63
region of the genome	63
we were unable to	63
by binding to the	63
viral load in the	63
these results indicated that	63
more than of the	63
and the expression of	63
to play an important	63
is interesting to note	63
in order to obtain	63
used to evaluate the	63
with novel coronavirus in	63
presence of viral rna	63
has been reported for	63
been implicated in the	63
has been suggested to	63
patients infected with novel	63
play an essential role	63
have been described in	63
could be used for	63
in one of the	63
progress has been made	63
at least one of	63
a mutation in the	62
was also detected in	62
can be applied to	62
was used to detect	62
of the use of	62
seems to be a	62
upper and lower respiratory	62
replication of the viral	62
features of patients infected	62
reduce the risk of	62
authors would like to	62
as is the case	62
the viral rna polymerase	62
as an internal control	62
is used as a	62
play a major role	62
in the middle of	62
to the host cell	62
in this study was	62
the crystal structures of	62
for the induction of	62
induce the formation of	62
the members of the	62
is the first report	62
with a history of	62
or in combination with	62
in the serum of	62
the national center for	62
is critical for the	62
assay for the detection	61
the past few years	61
from the nucleus to	61
the level of the	61
in the inhibition of	61
and activator of transcription	61
the coding region of	61
significant differences in the	61
cytoplasm of infected cells	61
it is conceivable that	61
included in the study	61
which is essential for	61
not included in the	61
for a variety of	61
the plasma membrane of	61
of the interaction between	61
the relative abundance of	61
of blood and blood	61
article distributed under the	61
innate and adaptive immunity	61
at the molecular level	61
by the innate immune	61
can be explained by	61
it was suggested that	61
this version posted may	61
small cell lung cancer	61
the results indicate that	61
the understanding of the	61
is a potent inhibitor	61
the viral genome is	61
this is the case	61
transducer and activator of	61
plays an essential role	61
as part of a	61
and incubated for h	61
the lower respiratory tract	61
for a number of	60
a negative regulator of	60
to ensure that the	60
the antiviral effects of	60
in balb c mice	60
not appear to be	60
sars coronavirus nucleocapsid protein	60
online version of this	60
have been proposed to	60
to interfere with the	60
a reduction in the	60
mode of action of	60
were no significant differences	60
of red blood cells	60
each of the three	60
it is worth noting	60
was not associated with	60
major role in the	60
avian coronavirus infectious bronchitis	60
we have demonstrated that	60
the viral replication complex	60
an overview of the	60
as in the case	60
no effect on the	60
of the coronavirus mouse	60
a h n virus	60
is a functional receptor	60
for a long time	60
the pcr products were	60
the authors would like	60
has been used in	60
the molecular mechanism of	60
the online version of	60
hepatitis c virus and	60
as shown in table	60
was similar to that	60
induction of type i	60
critically ill patients with	59
also been reported to	59
strand rna virus replication	59
during the study period	59
university school of medicine	59
test was used to	59
was associated with a	59
chronic hepatitis c virus	59
we conclude that the	59
have the ability to	59
access article distributed under	59
active site of the	59
was isolated from the	59
signal transducer and activator	59
used for the detection	59
is well known that	59
and the production of	59
the mechanism of the	59
by severe acute respiratory	59
a low level of	59
that are able to	59
to an increase in	59
the exception of the	59
in hek t cells	59
replication of the virus	59
in a previous study	59
of type i interferons	59
our study was to	59
and clinical characteristics of	59
the most commonly used	59
plays a major role	59
binding domain of the	59
supported by grants from	59
we have found that	59
s in supplementary material	59
that some of the	58
center for biotechnology information	58
regions of the genome	58
heterogeneous nuclear ribonucleoprotein a	58
used to assess the	58
were carried out using	58
rna was extracted using	58
the center of the	58
added to each well	58
for the determination of	58
with the addition of	58
was supported by grants	58
be the result of	58
that are associated with	58
as an alternative to	58
is worth noting that	58
compared with the control	58
patients infected with sars	58
of chronic hepatitis c	58
the most widely used	58
proteolytic processing of the	58
the distribution of the	58
of nsp and nsp	58
have also been shown	58
type i ifn signaling	58
study was designed to	58
of novel coronavirus pneumonia	58
in the early s	58
i and type ii	58
reverse genetics system for	58
the sequences of the	58
which is involved in	58
a change in the	58
of the viral replication	58
was also found to	58
of the influenza a	58
were used to determine	58
diagnosis and treatment of	58
the host immune system	58
was found that the	58
we also found that	58
the treatment of patients	58
by a combination of	57
our data show that	57
analysis of the sars	57
to be used as	57
the extent to which	57
were incubated for h	57
the virus and the	57
performed as described previously	57
as a source of	57
in the upper respiratory	57
the severity of the	57
coding region of the	57
replication and transcription of	57
of the viral proteins	57
replication of hepatitis c	57
the treatment of sars	57
the generation of a	57
aim of the present	57
were included in this	57
will be required to	57
in comparison with the	57
novel coronavirus in wuhan	57
likely due to the	57
for the purpose of	57
without the need for	57
for the discovery of	57
respiratory syndrome coronavirus replication	57
infectious bursal disease virus	57
in the infected cells	57
of mutations in the	57
a comparison of the	57
of the active site	57
the sensitivity and specificity	57
cells in response to	57
in health and disease	57
the purpose of the	57
was used in the	57
hepatitis b virus infection	57
the development of an	57
the nuclear pore complex	57
and the absence of	57
it has been found	57
be used as an	57
of borna disease virus	57
is likely that the	57
was shown that the	57
expression of type i	56
has been described in	56
the gene of interest	56
could be used as	56
based on these results	56
influenza a virus ns	56
the cells were incubated	56
antiviral innate immune response	56
of the effect of	56
have been demonstrated to	56
we did not observe	56
by grants from the	56
in the diagnosis of	56
specific cd t cells	56
we have investigated the	56
the core of the	56
there is a need	56
with acute respiratory distress	56
is located at the	56
read and approved the	56
there was no difference	56
with regard to the	56
was identified as a	56
coronavirus ribosomal frameshifting signal	56
replication by rna interference	56
entry into host cells	56
in human immunodeficiency virus	56
at different stages of	56
cd t cells in	56
we sought to determine	56
member of the family	56
with the plasma membrane	56
treatment of chronic hepatitis	56
in the supplemental material	56
in the region of	56
involved in the formation	56
essential for viral replication	56
and the lack of	55
in the amount of	55
results of this study	55
in the cytoplasm and	55
was supported by a	55
the scope of this	55
at the surface of	55
of viral gene expression	55
gene expression in the	55
genome sequence of the	55
of viral nucleic acid	55
are required for the	55
inhibits the replication of	55
is also involved in	55
would be expected to	55
pcr was performed using	55
a and b viruses	55
to the site of	55
in the levels of	55
in the face of	55
of host protein synthesis	55
and approved the final	55
time polymerase chain reaction	55
on the development of	55
the hepatitis e virus	55
treatment of patients with	55
was kindly provided by	55
expression in response to	55
as a target for	55
in the identification of	55
to be present in	55
dependent rna polymerase of	55
are associated with the	55
has been used for	55
these results show that	55
the host innate immune	55
to further investigate the	55
and the effect of	55
and the formation of	55
it was possible to	55
been identified as a	55
the treatment of chronic	54
the production of a	54
of differentially expressed genes	54
is the case for	54
the hepatitis b virus	54
in order to prevent	54
in the same way	54
at a density of	54
to act as a	54
the identification of a	54
is in agreement with	54
parts of the world	54
might be due to	54
virus replication in the	54
resulted in a significant	54
has been found that	54
is the use of	54
regulates the expression of	54
used to study the	54
cells were fixed and	54
determine the effect of	54
a powerful tool for	54
of bovine viral diarrhea	54
the difference between the	54
over the course of	54
been suggested that the	54
been shown to interact	54
and phylogenetic analysis of	54
incubated at room temperature	54
with that of the	54
coronavirus in patients with	54
statistical analysis was performed	54
was used to identify	54
in this study are	54
for the activation of	54
development and evaluation of	54
identification of a new	54
type i interferon signaling	54
through the use of	54
to test this hypothesis	54
of the viral envelope	54
one or more of	54
were present in the	54
the present study we	54
has been used as	53
investigate the role of	53
the n protein of	53
the gene encoding the	53
to the generation of	53
it has recently been	53
which can be used	53
the product of the	53
at an early stage	53
the presence of mg	53
by the immune system	53
results indicated that the	53
in a final volume	53
was performed on the	53
would be interesting to	53
of brome mosaic virus	53
the presence of these	53
in the release of	53
the nucleus to the	53
respiratory tract infections in	53
to be related to	53
in order to understand	53
in the nucleus of	53
has been made in	53
detection and characterization of	53
cells were maintained in	53
it would be interesting	53
the ends of the	53
the cells were then	53
the structure of a	53
is a prerequisite for	53
it will be interesting	53
is defined as the	53
to determine the effect	53
was found to have	53
from the plasma membrane	53
probably due to the	53
and expression of the	53
which is known to	53
our data indicate that	53
present study was to	53
at g for min	53
been proposed to be	53
these data demonstrate that	52
functional receptor for the	52
performed according to the	52
more likely to be	52
the presence of virus	52
of zika virus in	52
and its role in	52
in a wide range	52
were washed twice with	52
protein of severe acute	52
the qiaamp viral rna	52
are located in the	52
cells were incubated for	52
for the prevention of	52
it is tempting to	52
in all of the	52
an increased risk of	52
cell leukemia virus type	52
into the host genome	52
terminal region of the	52
used as a control	52
was performed according to	52
has been found in	52
with a variety of	52
a potential target for	52
samples from patients with	52
mouse hepatitis virus a	52
was estimated to be	52
this version posted july	52
results are consistent with	52
the complexity of the	52
of innate immune responses	52
the free energy of	52
transcription and replication of	52
open reading frame of	52
gene expression and replication	52
are essential for the	52
of rna secondary structure	52
of a series of	52
from the endoplasmic reticulum	52
carried out in a	51
has been demonstrated in	51
for the initiation of	51
the region of the	51
may be responsible for	51
the genomic rna of	51
be attributed to the	51
are more likely to	51
have been linked to	51
mechanisms of action of	51
was supported in part	51
not present in the	51
does not seem to	51
viruses belonging to the	51
will be interesting to	51
de groot et al	51
in vitro selection of	51
hepatitis b surface antigen	51
found to be the	51
southern bean mosaic virus	51
epidemiology of novel coronavirus	51
further studies are required	51
for the management of	51
amino acids of the	51
the therapeutic potential of	51
c for min and	51
to the release of	51
hepatitis c virus nonstructural	51
compared to those of	51
in vitro translation of	51
was determined to be	51
for the delivery of	51
ebola and marburg viruses	51
on the number of	51
on the mechanism of	50
region of the viral	50
which is available to	50
was carried out with	50
protein is required for	50
were significantly higher than	50
a portion of the	50
for virus origins and	50
largest rna virus genome	50
the possible role of	50
virus origins and receptor	50
hepatitis b virus replication	50
essential for virus replication	50
genes involved in the	50
in the human population	50
when compared with the	50
innate immune response by	50
as the gene source	50
might be involved in	50
to the control group	50
in the plasma membrane	50
cd t cells and	50
the goal of this	50
the synthesis of viral	50
and functional characterization of	50
coronaviruses as the gene	50
the leading cause of	50
and epidemiology of novel	50
in order to study	50
the case of a	50
were incubated with the	50
the gene source of	50
are among the most	50
as a loading control	50
will be discussed in	50
the production of the	50
in peripheral blood mononuclear	50
the ratio of the	50
has been identified in	50
implications for virus origins	50
of the ebola virus	50
in the immune response	50
in addition to these	50
was also observed in	50
origins and receptor binding	50
regions of the viral	50
in the early stages	50
the cells were harvested	50
the porcine reproductive and	50
on the type of	50
have yet to be	50
of rna viruses in	50
minutes at room temperature	50
was performed with the	50
to the surface of	50
a vital role in	50
approved for the treatment	50
evs were isolated from	50
which is required for	50
the inhibitory effects of	50
the adaptive immune response	50
for viral rna synthesis	50
to the inhibition of	50
the centers for disease	50
associated with an increased	50
of the expression of	49
experiments were performed in	49
taking into account the	49
or more of the	49
available to authorized users	49
the addition of a	49
cause of severe acute	49
with the number of	49
fluorescence resonance energy transfer	49
hepatitis b and c	49
the viral load in	49
and is blocked by	49
for in vitro transcription	49
in a similar manner	49
which is responsible for	49
viral replication and transcription	49
understanding of the molecular	49
as well as an	49
this is due to	49
of the human immunodeficiency	49
the a and b	49
may be important for	49
to the viral rna	49
the formation of an	49
in our understanding of	49
is determined by the	49
and specificity of the	49
the loss of the	49
of allergy and infectious	49
the difference in the	49
entry into the host	49
and lower respiratory tract	49
is blocked by a	49
in addition to this	49
american type culture collection	49
of cd and cd	49
can lead to the	49
had no role in	49
in the setting of	49
that are essential for	49
can be considered as	49
the top of the	49
considered to be a	49
a total volume of	49
in vivo delivery of	49
by the lack of	49
in viral rna replication	49
data indicate that the	49
by small interfering rnas	49
shed light on the	49
has been applied to	49
of rift valley fever	49
in order to achieve	49
the jak stat pathway	49
the absence or presence	49
the duration of the	49
is available to authorized	49
with the aim of	49
this version posted april	49
a function of the	49
these results suggested that	49
of the endoplasmic reticulum	49
and respiratory syncytial virus	49
the addition of the	49
respiratory syndrome coronavirus and	49
transcriptase polymerase chain reaction	49
study was approved by	49
significantly higher than that	49
the amino acid sequences	49
a nested set of	49
of viral replication and	48
remains to be elucidated	48
here we show that	48
a novel class of	48
the safety and efficacy	48
the ns a protein	48
the first report of	48
and in some cases	48
can serve as a	48
proteins involved in the	48
nucleus to the cytoplasm	48
aimed to investigate the	48
to the active site	48
are found in the	48
ace and tmprss and	48
entry depends on ace	48
is composed of a	48
absence or presence of	48
in humans and animals	48
in vitro antiviral activity	48
of the effects of	48
due to lack of	48
and west nile virus	48
cell entry depends on	48
in the peripheral blood	48
with an increase in	48
on ace and tmprss	48
detect the presence of	48
was determined by the	48
and tmprss and is	48
of novel coronavirus in	48
reticulovesicular network of modified	48
been used as a	48
in the presence and	48
in patients infected with	48
cells were washed twice	48
a number of different	48
depends on ace and	48
can be achieved by	48
transmission of the virus	48
for the preparation of	48
is referred to as	48
associated with acute respiratory	48
at c for min	48
makes it possible to	48
was not affected by	48
inhibition of hepatitis c	48
the conformation of the	48
critical role in the	48
dependent rna polymerase and	48
with the ability to	48
is associated with an	48
also been found to	48
a review of the	48
may play an important	48
by a variety of	48
is associated with increased	48
type i interferon induction	48
early stages of infection	47
blocked by a clinically	47
the rough endoplasmic reticulum	47
was not due to	47
and replication of the	47
to the pathogenesis of	47
expression in mammalian cells	47
of the th century	47
by interacting with the	47
experiments were carried out	47
was based on the	47
defective interfering particles of	47
of three independent experiments	47
tmprss and is blocked	47
analysis revealed that the	47
approved the final manuscript	47
it is essential to	47
innate immune responses to	47
a clinically proven protease	47
t cells in the	47
be considered as a	47
cells were incubated at	47
by a clinically proven	47
protein is involved in	47
was performed as previously	47
red clover necrotic mosaic	47
structural and accessory proteins	47
the accuracy of the	47
and the level of	47
in combination with a	47
the complete nucleotide sequence	47
to be due to	47
on ice for min	47
there were no differences	47
the evolutionary history of	47
it is not possible	47
are the most common	47
it was concluded that	47
the efficacy of the	47
institute of allergy and	47
with a mixture of	47
the properties of the	47
and evaluation of a	47
by nanoparticle tracking analysis	47
member of the genus	47
its interaction with the	47
been shown to bind	47
on the host cell	47
in response to virus	47
an infectious cdna clone	47
the expression of genes	47
to the emergence of	47
in vitro transcription of	47
be used to identify	47
of some of the	47
the cells were fixed	47
we propose that the	47
is likely due to	47
shown to play a	47
in infected cells and	47
the production of type	47
of type i and	47
to the expression of	47
h n avian influenza	47
at the expense of	47
the enzymatic activity of	47
has also been observed	47
in combination with other	47
has been linked to	47
animal care and use	47
also play a role	47
internal initiation of translation	47
through the activation of	47
this may be due	47
we observed that the	47
to the study of	47
carried out in the	47
to hepatitis c virus	47
national institute of allergy	47
have been reported for	47
here we report the	47
that is required for	47
respiratory syndrome coronavirus nucleocapsid	47
novel coronavirus in patients	47
the protein data bank	47
was significantly lower in	47
the expression of these	47
the detection limit of	47
clinically proven protease inhibitor	46
in the innate immune	46
host innate immune response	46
confirmed the presence of	46
and the ability to	46
could not be detected	46
is caused by a	46
it was proposed that	46
of h n influenza	46
of the rna genome	46
the results of these	46
have demonstrated that the	46
the influence of the	46
as the template for	46
moloney murine leukemia virus	46
with the fact that	46
are included in the	46
for the evaluation of	46
used in the treatment	46
presence and absence of	46
and their role in	46
of influenza a and	46
leads to the formation	46
genomic characterisation and epidemiology	46
which has been shown	46
virological assessment of hospitalized	46
initiation of rna synthesis	46
is a component of	46
authors read and approved	46
these observations suggest that	46
human rhinovirus c protease	46
our results demonstrate that	46
for the construction of	46
detection of influenza a	46
it has been observed	46
the frequency of the	46
were more likely to	46
a systematic review of	46
a molecular weight of	46
used for statistical analysis	46
that are required for	46
has not been reported	46
crystal structures of the	46
in the absence or	46
of rna secondary structures	46
the design of the	46
investigate the effects of	46
was also shown to	46
all members of the	46
due to the low	46
close proximity to the	46
spike protein of sars	46
new coronavirus associated with	46
as well as its	46
the composition of the	46
is a multifunctional protein	46
a number of other	46
is not possible to	46
shown to be involved	46
guanine nucleotide exchange factor	46
and an increase in	46
with the formation of	46
be associated with the	46
be used to detect	46
the first step in	46
characterisation and epidemiology of	46
the amount of viral	46
at a final concentration	46
has proven to be	46
antiviral activity of the	46
also found to be	46
compared to the wild	46
a large proportion of	46
significant difference between the	46
it is not surprising	46
a total of samples	46
by the end of	46
used for the treatment	46
and evolution of the	46
a new coronavirus associated	46
of modified endoplasmic reticulum	45
the viruses and their	45
even in the absence	45
patients with coronavirus disease	45
were infected with the	45
the first step of	45
conserved features of genome	45
of the respiratory tract	45
the vesicular stomatitis virus	45
by rna polymerase ii	45
infected or infected with	45
of reads mapping to	45
of genome and proteome	45
of the west nile	45
have been used for	45
unique and conserved features	45
essential role in the	45
the emergence of the	45
the first and second	45
against hepatitis c virus	45
a reticulovesicular network of	45
the role of this	45
in order to increase	45
type i ifn response	45
is the number of	45
the translation of the	45
was used to assess	45
this indicates that the	45
of the target gene	45
and conserved features of	45
for viral rna replication	45
of the e protein	45
translation initiation factor eif	45
isolation of a novel	45
the coronavirus group lineage	45
fusion of the viral	45
conformational changes in the	45
of the flaviviridae family	45
based on the use	45
of the structural proteins	45
is an open access	45
features of genome and	45
been identified in the	45
an inhibitor of the	45
in response to viral	45
from each of the	45
open access article distributed	45
the result of a	45
tempting to speculate that	45
network of modified endoplasmic	45
which are involved in	45
influenza a virus in	45
is derived from the	45
the presence of mm	45
of viruses in the	45
which is associated with	45
type i and iii	45
do not appear to	45
which leads to the	45
genome and proteome of	45
the result of the	45
the characterization of the	45
the remainder of the	45
over the last years	45
the h n virus	45
can be seen in	45
for minutes at room	45
to investigate the role	45
of the unfolded protein	45
was used as an	45
infectious cdna clone of	45
characteristics of cases of	45
is not known whether	45
before and after the	45
carried out using the	45
the cytoplasm of the	45
the internal ribosome entry	45
an open access article	45
were also detected in	45
it is unlikely that	45
were carried out with	45
it is unclear whether	45
from the coronavirus group	45
study the effect of	45
been shown to induce	45
care and use committee	45
off from the coronavirus	44
activation of rnase l	44
in the use of	44
a risk factor for	44
t rna polymerase promoter	44
were not significantly different	44
virus in cell culture	44
appears to be the	44
coronavirus nonstructural protein nsp	44
been suggested to be	44
the development of antiviral	44
genome replication and transcription	44
as a tool for	44
to a decrease in	44
not seem to be	44
and a number of	44
resuspended in ml of	44
to be effective in	44
a template for the	44
the catalytic activity of	44
to the absence of	44
titers were determined by	44
formation of stress granules	44
at each time point	44
in the liver and	44
inhibition of hepatitis b	44
a and ns b	44
the last few years	44
dependent rna polymerase activity	44
of the viral mrna	44
of mice infected with	44
influenza a virus replication	44
lower respiratory tract infections	44
on the nature of	44
have been suggested to	44
of one or more	44
is crucial for the	44
with chronic hepatitis b	44
the genetic diversity of	44
with the host cell	44
c virus ns b	44
we showed that the	44
of p and p	44
strand rna viruses and	44
in the modulation of	44
it may be possible	44
the n protein is	44
our findings suggest that	44
respiratory syndrome coronavirus spike	44
were transfected with the	44
rna synthesis by the	44
is not well understood	44
one of the three	44
identical to that of	44
the discovery of the	44
genome sequence of a	44
for min followed by	44
and to a lesser	44
will be needed to	44
was also used to	44
than those of the	44
reading of the manuscript	44
is not fully understood	44
respiratory syndrome coronavirus nonstructural	44
with the novel coronavirus	44
note springer nature remains	43
the absence of an	43
play a pivotal role	43
in the brains of	43
the intensity of the	43
in order to be	43
were found to have	43
leading to the formation	43
dependent on the presence	43
mediated by the viral	43
novel coronavirus from a	43
genomic and subgenomic rna	43
single open reading frame	43
that there is no	43
in the spike protein	43
mouse hepatitis virus rna	43
rna secondary structure prediction	43
replicate in the cytoplasm	43
these data show that	43
the helicase activity of	43
the establishment of a	43
of the infected cells	43
in order to avoid	43
is characterized by a	43
upper respiratory tract infections	43
cell culture and in	43
in hospitalized patients with	43
the results of our	43
of the capsid protein	43
with feline infectious peritonitis	43
the production of ifn	43
innate immune response in	43
fever with renal syndrome	43
of gene expression by	43
will be necessary to	43
this research was supported	43
production of infectious virus	43
order to determine the	43
patients with novel coronavirus	43
the organization of the	43
have been used in	43
as a cause of	43
for the assembly of	43
the importance of this	43
the normalized shannon entropy	43
em structure of the	43
phase i clinical trial	43
used to calculate the	43
respiratory syncytial virus and	43
rna replication and transcription	43
human parainfluenza virus type	43
in a murine model	43
expressed in escherichia coli	43
is mediated by a	43
to investigate the effects	43
tumor necrosis factor alpha	43
in the life cycle	43
the mode of action	43
to be used in	43
viruses and their replication	43
of the gene encoding	43
used in combination with	43
from the end of	43
of the university of	43
as well as on	43
for the regulation of	43
human respiratory disease in	43
the induction of ifn	43
and the evolution of	43
of viral rna was	43
with human respiratory disease	43
most closely related to	43
of g s in	43
to contribute to the	43
was used for statistical	43
proteolytic cleavage of the	43
was used to evaluate	42
a significant proportion of	42
by means of the	42
this article is an	42
involved in the pathogenesis	42
with a number of	42
a significant number of	42
samples were obtained from	42
could be explained by	42
article can be found	42
expression of the viral	42
a man with pneumonia	42
the atpase activity of	42
allergy and infectious diseases	42
supported by a reticulovesicular	42
the concentration of the	42
the induction of apoptosis	42
hepatitis e virus infection	42
to confirm that the	42
different from that of	42
for min at rt	42
the viral rna and	42
replication is supported by	42
of the s rrna	42
a region of the	42
no conflicts of interest	42
are presented in table	42
have been made to	42
was carried out at	42
used as a model	42
in the golgi complex	42
in support of this	42
as a model system	42
as a model for	42
c virus replication by	42
was identified as the	42
by a reticulovesicular network	42
was performed to determine	42
inhibition of viral replication	42
may act as a	42
as well as of	42
understand the role of	42
the results indicated that	42
is based on a	42
recent studies have shown	42
a subset of the	42
in the emergence of	42
the control of a	42
assessment of hospitalized patients	42
similar to that observed	42
s in the supplemental	42
to the endoplasmic reticulum	42
replication of mouse hepatitis	42
of the viral polymerase	42
is encoded by the	42
reading frame of the	42
may be used to	42
this study aimed to	42
in cd t cells	42
have been isolated from	42
and found that the	42
induced pluripotent stem cells	42
able to interact with	42
coronavirus associated with human	42
of the structure of	42
s protein of sars	42
the presence and absence	42
of viral and cellular	42
were used in this	42
associated with human respiratory	42
and has been shown	42
forward and reverse primers	42
fold serial dilutions of	42
it is not yet	42
we aimed to investigate	42
least one of the	42
in contrast to other	42
one of the best	42
respiratory disease in china	42
of amino acid residues	42
to be positive for	42
first line of defense	42
supplementary figure s a	42
molecular evolutionary genetics analysis	42
exclude the possibility that	42
were performed as described	42
can be detected by	42
been identified as the	42
to be used for	42
clinical characteristics of cases	42
the potential to be	42
were used to generate	42
by the severe acute	42
with the viral rna	42
viral gene expression and	42
control of gene expression	42
safety and immunogenicity of	42
infectious hepatitis c virus	42
was determined using the	42
the treatment of severe	41
both of which are	41
in different types of	41
with pneumonia in saudi	41
based on the results	41
detection and identification of	41
to gain insight into	41
and analysis of the	41
the base of the	41
amino acids in the	41
has the ability to	41
no significant difference between	41
from a man with	41
the mouse hepatitis virus	41
the bottom of the	41
the early secretory pathway	41
at the protein level	41
is not yet known	41
and antiviral activity of	41
brome mosaic virus rna	41
was present in the	41
to study the effect	41
target for the development	41
of the rna polymerase	41
by the viral polymerase	41
novel coronavirus pneumonia in	41
the dynamics of the	41
of the virus genome	41
it is reported that	41
of the human coronavirus	41
is tempting to speculate	41
be taken into account	41
of the orf a	41
significantly higher in the	41
did not lead to	41
a a a a	41
it is reasonable to	41
has been described for	41
were mapped to the	41
the plasma membrane and	41
the introduction of a	41
some of which are	41
to participate in the	41
a virus ns protein	41
article is an open	41
in the crystal structure	41
the terms and conditions	41
a number of viruses	41
and proteome of sars	41