This is a table of type quadgram and their frequencies. Use it to search & browse the list to learn more about your study carrel.
quadgram | frequency |
---|---|
severe acute respiratory syndrome | 2520 |
in the presence of | 1800 |
acute respiratory syndrome coronavirus | 1527 |
in the absence of | 1118 |
in the case of | 955 |
has been shown to | 886 |
on the other hand | 851 |
for the treatment of | 815 |
of hepatitis c virus | 799 |
as well as the | 779 |
for the detection of | 772 |
middle east respiratory syndrome | 755 |
of severe acute respiratory | 748 |
in the context of | 713 |
in vitro and in | 690 |
porcine reproductive and respiratory | 683 |
reproductive and respiratory syndrome | 678 |
vitro and in vivo | 619 |
and respiratory syndrome virus | 607 |
have been shown to | 606 |
the end of the | 596 |
an important role in | 593 |
east respiratory syndrome coronavirus | 560 |
human immunodeficiency virus type | 556 |
one of the most | 541 |
was found to be | 533 |
is one of the | 529 |
medrxiv a license to | 502 |
a license to display | 502 |
to display the preprint | 502 |
has granted medrxiv a | 502 |
granted medrxiv a license | 502 |
who has granted medrxiv | 502 |
license to display the | 502 |
display the preprint in | 502 |
can be used to | 482 |
is the author funder | 473 |
at the end of | 473 |
been shown to be | 471 |
copyright holder for this | 464 |
the copyright holder for | 464 |
of the viral genome | 457 |
play a role in | 450 |
in the treatment of | 443 |
the preprint in perpetuity | 441 |
a wide range of | 434 |
for the development of | 428 |
the aim of this | 428 |
as a result of | 426 |
of mouse hepatitis virus | 425 |
it has been shown | 418 |
of this study was | 417 |
in addition to the | 413 |
in the present study | 403 |
the presence of a | 402 |
the presence of the | 401 |
this study was to | 399 |
the severe acute respiratory | 398 |
on the basis of | 395 |
european food safety authority | 390 |
the european food safety | 389 |
a large number of | 385 |
aim of this study | 377 |
in the regulation of | 373 |
it is possible that | 365 |
it is important to | 365 |
were found to be | 365 |
holder for this preprint | 360 |
on the surface of | 349 |
has been shown that | 347 |
cells were infected with | 340 |
at the same time | 335 |
was used as a | 318 |
the structure of the | 316 |
at the time of | 316 |
preprint this version posted | 315 |
studies have shown that | 315 |
for this preprint this | 315 |
this preprint this version | 315 |
the hepatitis c virus | 314 |
in the united states | 309 |
play an important role | 308 |
these results suggest that | 306 |
as well as in | 305 |
for the first time | 305 |
in the development of | 304 |
this work was supported | 297 |
of the viral rna | 296 |
of human immunodeficiency virus | 296 |
it is made available | 289 |
international license it is | 288 |
hepatitis c virus rna | 288 |
made available under a | 288 |
license it is made | 288 |
is made available under | 288 |
rna was extracted from | 286 |
to be involved in | 285 |
for the presence of | 280 |
certified by peer review | 280 |
work was supported by | 280 |
of porcine reproductive and | 280 |
not certified by peer | 280 |
was not certified by | 279 |
a member of the | 278 |
the innate immune response | 278 |
used in this study | 277 |
a is the author | 272 |
available under a is | 272 |
under a is the | 272 |
the formation of the | 267 |
similar to that of | 266 |
the role of the | 261 |
plays an important role | 259 |
which was not certified | 258 |
porcine epidemic diarrhea virus | 256 |
as shown in fig | 254 |
in the formation of | 253 |
the expression of the | 253 |
the central nervous system | 251 |
in the pathogenesis of | 250 |
the crystal structure of | 248 |
in contrast to the | 248 |
it was shown that | 246 |
a role in the | 244 |
presence or absence of | 236 |
the total number of | 235 |
important role in the | 234 |
of influenza a virus | 233 |
it is likely that | 232 |
the context of a | 232 |
cells were transfected with | 230 |
we were able to | 229 |
acute respiratory distress syndrome | 228 |
to the development of | 227 |
crystal structure of the | 226 |
it is possible to | 226 |
with severe acute respiratory | 224 |
we found that the | 221 |
in cells infected with | 220 |
cells were treated with | 219 |
hepatitis c virus replication | 218 |
r n a l | 217 |
p r o o | 216 |
o u r n | 216 |
u r n a | 216 |
a l p r | 216 |
n a l p | 216 |
j o u r | 216 |
l p r e | 216 |
r o o f | 216 |
a key role in | 215 |
the antiviral activity of | 214 |
has been carried out | 214 |
hepatitis c virus infection | 213 |
was added to the | 213 |
aim of the study | 213 |
it was found that | 213 |
to that of the | 213 |
the surface of the | 212 |
as shown in figure | 212 |
of viral rna in | 211 |
herpes simplex virus type | 211 |
the size of the | 209 |
has been reported to | 208 |
in the form of | 208 |
it has been reported | 208 |
with the exception of | 207 |
the presence or absence | 207 |
be considered as an | 207 |
it may not be | 205 |
was shown to be | 204 |
is based on the | 204 |
identification and characterization of | 204 |
the viral life cycle | 204 |
not be considered as | 203 |
as well as a | 203 |
these results indicate that | 202 |
of hepatitis b virus | 201 |
in the number of | 199 |
plays a role in | 197 |
is involved in the | 196 |
these data suggest that | 195 |
of a novel coronavirus | 195 |
as regards the issues | 194 |
and the conclusions reached | 194 |
reached in the present | 194 |
addressed and the conclusions | 194 |
view and position as | 194 |
and position as regards | 194 |
the conclusions reached in | 194 |
in the present document | 194 |
safety authority reserves its | 194 |
may not be considered | 194 |
position as regards the | 194 |
food safety authority reserves | 194 |
the issues addressed and | 194 |
authority reserves its rights | 194 |
regards the issues addressed | 194 |
issues addressed and the | 194 |
conclusions reached in the | 194 |
awarded following a tender | 193 |
a contract between the | 193 |
published complying with the | 193 |
adopted by the authority | 193 |
to which the authority | 193 |
this task has been | 193 |
food safety authority and | 193 |
considered as an output | 193 |
principle to which the | 193 |
document is published complying | 193 |
the present document is | 193 |
carried out exclusively by | 193 |
as an output adopted | 193 |
safety authority and the | 193 |
following a tender procedure | 193 |
transparency principle to which | 193 |
out exclusively by the | 193 |
the authority is subject | 193 |
task has been carried | 193 |
which the authority is | 193 |
the transparency principle to | 193 |
of a contract between | 193 |
output adopted by the | 193 |
an output adopted by | 193 |
between the european food | 193 |
context of a contract | 193 |
with the transparency principle | 193 |
complying with the transparency | 193 |
been carried out exclusively | 193 |
present document is published | 193 |
is published complying with | 193 |
contract between the european | 193 |
it has been suggested | 192 |
are involved in the | 190 |
end of the genome | 189 |
the ability of the | 189 |
has been reported that | 188 |
of herpes simplex virus | 188 |
of this study is | 187 |
by the presence of | 187 |
in a mouse model | 187 |
in this study we | 186 |
the rights of the | 186 |
be involved in the | 186 |
avian infectious bronchitis virus | 186 |
without prejudice to the | 185 |
hepatitis c virus ns | 185 |
the innate immune system | 185 |
to the rights of | 185 |
prejudice to the rights | 185 |
by the bodies identified | 184 |
and adopted by the | 184 |
produced and adopted by | 184 |
has been produced and | 184 |
been produced and adopted | 184 |
present document has been | 184 |
the present document has | 184 |
adopted by the bodies | 184 |
the bodies identified above | 184 |
bodies identified above as | 184 |
document has been produced | 184 |
internal ribosome entry site | 183 |
as a function of | 182 |
the length of the | 181 |
at an moi of | 180 |
coronavirus infectious bronchitis virus | 179 |
it should be noted | 179 |
was supported by the | 177 |
the formation of a | 176 |
to the formation of | 176 |
of west nile virus | 176 |
the nature of the | 176 |
peripheral blood mononuclear cells | 176 |
is consistent with the | 176 |
disease control and prevention | 176 |
the development of a | 176 |
at the level of | 176 |
the majority of the | 174 |
our understanding of the | 174 |
can be used for | 174 |
has been suggested that | 174 |
of the hepatitis c | 174 |
a wide variety of | 173 |
to the presence of | 173 |
the results of the | 173 |
of the innate immune | 173 |
the activation of the | 171 |
with respect to the | 170 |
is responsible for the | 170 |
by the authors in | 169 |
may be due to | 169 |
authority and the authors | 168 |
exclusively by the authors | 168 |
the authors in the | 168 |
should be noted that | 168 |
authors in the context | 168 |
a critical role in | 168 |
during the course of | 167 |
for disease control and | 167 |
identified above as authors | 167 |
rights of the authors | 167 |
was performed using the | 166 |
the expression levels of | 166 |
for the production of | 166 |
the world health organization | 166 |
this is the first | 165 |
little is known about | 165 |
the specificity of the | 165 |
to be associated with | 164 |
of type i ifn | 162 |
under the control of | 162 |
of middle east respiratory | 162 |
have been reported to | 161 |
the sequence of the | 161 |
a crucial role in | 161 |
in the production of | 161 |
this study is to | 160 |
can be used as | 160 |
of vesicular stomatitis virus | 159 |
of the immune system | 159 |
has been used to | 158 |
total rna was extracted | 158 |
as compared to the | 158 |
be used as a | 158 |
at room temperature for | 158 |
in the course of | 157 |
was detected in the | 156 |
in a variety of | 156 |
by the addition of | 156 |
for the synthesis of | 155 |
a broad range of | 155 |
the aim of the | 154 |
in patients with severe | 154 |
bovine viral diarrhea virus | 153 |
the use of a | 153 |
the function of the | 152 |
an increase in the | 152 |
the fact that the | 152 |
in the cytoplasm of | 151 |
structure and function of | 151 |
is required for the | 151 |
there was no significant | 151 |
be due to the | 151 |
as a template for | 149 |
the results showed that | 149 |
have shown that the | 149 |
the use of the | 148 |
isolation and characterization of | 148 |
have been used to | 146 |
that can be used | 146 |
of the n protein | 146 |
international committee on taxonomy | 145 |
the limit of detection | 145 |
rna was detected in | 145 |
of the virus in | 145 |
of feline infectious peritonitis | 145 |
mechanism of action of | 144 |
the case of the | 144 |
committee on taxonomy of | 143 |
rift valley fever virus | 142 |
national institutes of health | 142 |
a major role in | 142 |
of the sars coronavirus | 142 |
the rest of the | 142 |
the active site of | 142 |
a final concentration of | 142 |
also been shown to | 141 |
we have shown that | 141 |
patients with chronic hepatitis | 140 |
of hepatitis e virus | 140 |
a better understanding of | 140 |
in the presence or | 140 |
and the number of | 140 |
in vivo and in | 140 |
can be found in | 139 |
may play a role | 139 |
venezuelan equine encephalitis virus | 138 |
is known about the | 138 |
the authors declare no | 138 |
been found to be | 138 |
centers for disease control | 138 |
the activity of the | 138 |
have been found to | 138 |
for the study of | 137 |
the treatment of covid | 137 |
classical swine fever virus | 137 |
the molecular biology of | 137 |
is essential for the | 137 |
has not yet been | 136 |
it has also been | 136 |
it is known that | 136 |
the stability of the | 136 |
the human immunodeficiency virus | 136 |
for the diagnosis of | 136 |
for each of the | 135 |
vivo and in vitro | 135 |
of the host cell | 135 |
influenza a and b | 135 |
feline infectious peritonitis virus | 135 |
no conflict of interest | 135 |
the purpose of this | 134 |
one of the major | 134 |
in the expression of | 134 |
results suggest that the | 134 |
on taxonomy of viruses | 133 |
the international committee on | 133 |
is thought to be | 133 |
the effect of the | 133 |
is not required for | 133 |
the sensitivity of the | 133 |
as part of the | 132 |
of the genomic rna | 132 |
no reuse allowed without | 131 |
in patients with covid | 131 |
reuse allowed without permission | 131 |
the mechanism by which | 131 |
our results suggest that | 130 |
the beginning of the | 130 |
were detected in the | 130 |
with the use of | 130 |
in the field of | 130 |
the authors declare that | 130 |
has been found to | 129 |
h n influenza virus | 129 |
and characterization of a | 129 |
of type i interferon | 128 |
have been identified in | 128 |
min at room temperature | 128 |
the unfolded protein response | 127 |
is a member of | 127 |
in the process of | 127 |
coronavirus mouse hepatitis virus | 127 |
identification of a novel | 126 |
to determine whether the | 126 |
was observed in the | 126 |
the context of the | 126 |
for the identification of | 126 |
has the potential to | 126 |
both in vitro and | 126 |
as a consequence of | 126 |
the causative agent of | 125 |
an essential role in | 125 |
no significant difference in | 125 |
the type i interferon | 125 |
it has been proposed | 125 |
the importance of the | 124 |
studies are needed to | 124 |
orf a and orf | 124 |
may be involved in | 123 |
have the potential to | 123 |
is associated with the | 123 |
used to determine the | 123 |
our results show that | 123 |
the mechanism of action | 123 |
was used as the | 123 |
congo hemorrhagic fever virus | 123 |
had no effect on | 123 |
are likely to be | 121 |
as well as to | 121 |
of respiratory syncytial virus | 121 |
are known to be | 121 |
hepatitis c virus core | 121 |
the replication of the | 121 |
would like to thank | 121 |
is likely to be | 120 |
better understanding of the | 120 |
nucleotide sequence of the | 120 |
to the lack of | 120 |
cd and cd t | 120 |
the antiviral effect of | 120 |
rna dependent rna polymerase | 120 |
for hepatitis c virus | 119 |
has also been shown | 119 |
the basis of the | 119 |
has also been reported | 119 |
the nucleocapsid protein of | 119 |
a high degree of | 119 |
that there is a | 119 |
influenza a h n | 118 |
these data indicate that | 118 |
by the fact that | 118 |
than that of the | 118 |
of the severe acute | 118 |
on the use of | 118 |
as well as for | 118 |
other members of the | 117 |
the presence of an | 117 |
it has been demonstrated | 117 |
results indicate that the | 117 |
the development of new | 117 |
a mouse model of | 117 |
analysis was performed using | 116 |
been reported to be | 116 |
efficacy and safety of | 116 |
in the control of | 116 |
a small number of | 116 |
is known to be | 116 |
higher than that of | 116 |
vascular endothelial growth factor | 116 |
for min at room | 115 |
it remains to be | 115 |
with chronic hepatitis c | 115 |
of the virus to | 115 |
may contribute to the | 115 |
the control of the | 114 |
c virus rna replication | 114 |
was carried out using | 114 |
the life cycle of | 114 |
the course of the | 113 |
the vast majority of | 113 |
and the presence of | 113 |
the early stages of | 113 |
remains to be determined | 113 |
at the beginning of | 113 |
a significant increase in | 113 |
rna was isolated from | 113 |
detection of viral rna | 113 |
the absence of a | 112 |
of the human genome | 112 |
the presence of viral | 112 |
it is not clear | 112 |
the interaction between the | 112 |
has been associated with | 112 |
were included in the | 112 |
in the range of | 112 |
have been reported in | 112 |
on the presence of | 112 |
the analysis of the | 112 |
it is clear that | 112 |
for the generation of | 111 |
a novel coronavirus from | 111 |
pp a and pp | 111 |
in agreement with the | 111 |
of semliki forest virus | 111 |
for the formation of | 111 |
by hepatitis c virus | 111 |
the secondary structure of | 111 |
to interact with the | 110 |
the present study was | 110 |
the absence of the | 110 |
has been proposed that | 110 |
the detection of sars | 110 |
on the cell surface | 110 |
a potent inhibitor of | 110 |
in this study were | 110 |
when compared to the | 110 |
of infectious bronchitis virus | 109 |
the synthesis of the | 109 |
respiratory syndrome coronavirus infection | 109 |
can be detected in | 109 |
to the plasma membrane | 109 |
has been demonstrated that | 109 |
sequence analysis of the | 109 |
in hepatitis c virus | 108 |
is dependent on the | 108 |
of patients infected with | 108 |
of the s protein | 108 |
study was to investigate | 108 |
of a variety of | 107 |
a and orf b | 107 |
innate and adaptive immune | 107 |
is mediated by the | 107 |
similar to those of | 107 |
in the evolution of | 107 |
that they have no | 107 |
in any of the | 107 |
in the current study | 106 |
it is not known | 106 |
to be able to | 106 |
it is difficult to | 106 |
the amino acid sequence | 106 |
in a number of | 106 |
was used for the | 106 |
dna and rna viruses | 106 |
important to note that | 106 |
in the activation of | 106 |
as a negative control | 106 |
the influenza a virus | 106 |
were observed in the | 106 |
human respiratory syncytial virus | 106 |
of the influenza virus | 106 |
have been associated with | 106 |
it is necessary to | 106 |
of the most important | 106 |
is important to note | 106 |
that the presence of | 105 |
characterization of a novel | 105 |
due to the presence | 105 |
as one of the | 105 |
food and drug administration | 105 |
were shown to be | 105 |
play important roles in | 105 |
plays a key role | 105 |
of the immune response | 105 |
in the active site | 105 |
of viral rna synthesis | 105 |
by the use of | 105 |
was used to determine | 105 |
involved in the regulation | 104 |
viral rna mini kit | 104 |
due to the lack | 104 |
holder for this this | 104 |
in patients with chronic | 104 |
in vero e cells | 104 |
the existence of a | 104 |
this this version posted | 104 |
viral rna in the | 104 |
for this this version | 104 |
and function of the | 104 |
the development of the | 103 |
the assembly of the | 103 |
a and pp ab | 103 |
in accordance with the | 103 |
were added to the | 103 |
a limited number of | 103 |
of the present study | 103 |
is possible that the | 103 |
of murine hepatitis virus | 103 |
results showed that the | 103 |
declare that they have | 103 |
at a concentration of | 103 |
could be due to | 103 |
our data suggest that | 102 |
revealed the presence of | 102 |
n and h n | 101 |
regulation of gene expression | 101 |
type i ifn production | 101 |
to the fact that | 101 |
patients with severe covid | 101 |
h n and h | 101 |
a result of the | 101 |
these findings suggest that | 101 |
associated with severe acute | 101 |
purpose of this study | 100 |
of the virus and | 100 |
of a number of | 100 |
the expression level of | 100 |
have been found in | 100 |
between the two groups | 99 |
members of the family | 99 |
transcription polymerase chain reaction | 99 |
is required for efficient | 99 |
were found in the | 99 |
in an attempt to | 99 |
study was to determine | 99 |
in order to determine | 98 |
the upper respiratory tract | 98 |
we would like to | 98 |
new insights into the | 98 |
african swine fever virus | 98 |
was no significant difference | 98 |
structure of the rna | 98 |
a decrease in the | 97 |
followed by cycles of | 97 |
have been detected in | 97 |
were obtained from the | 97 |
of the role of | 97 |
the position of the | 97 |
authors declare that they | 97 |
incubated for h at | 97 |
the quality of the | 97 |
the binding of the | 97 |
of the murine coronavirus | 97 |
to the end of | 97 |
end of the viral | 97 |
with fetal bovine serum | 96 |
the identification of the | 96 |
was to investigate the | 96 |
is supported by the | 96 |
was performed using a | 96 |
we have developed a | 96 |
and the role of | 96 |
declare no conflict of | 96 |
in the replication of | 96 |
studies have demonstrated that | 96 |
and the development of | 96 |
in the central nervous | 96 |
our results indicate that | 96 |
a broad spectrum of | 95 |
are shown in fig | 95 |
the molecular basis of | 95 |
be explained by the | 95 |
at the plasma membrane | 95 |
authors declare no conflict | 95 |
a significant reduction in | 95 |
to play a role | 95 |
h at room temperature | 95 |
lower than that of | 95 |
could be used to | 95 |
dependent rna polymerase from | 95 |
is due to the | 94 |
complete genome sequence of | 94 |
have not yet been | 94 |
replication in cell culture | 94 |
to those of the | 94 |
in the genome of | 94 |
was performed as described | 94 |
the inhibitory effect of | 94 |
of the genome of | 94 |
is associated with a | 93 |
the spread of the | 93 |
is shown in fig | 93 |
in the control group | 93 |
to be the most | 93 |
eukaryotic translation initiation factor | 93 |
in the near future | 93 |
complete nucleotide sequence of | 92 |
of the international committee | 92 |
structural basis for the | 92 |
we have previously shown | 92 |
be related to the | 92 |
chronic obstructive pulmonary disease | 92 |
viral rna was detected | 92 |
a multiplicity of infection | 92 |
the expression of a | 92 |
innate immune response to | 92 |
be responsible for the | 91 |
no relationships to disclose | 91 |
qiaamp viral rna mini | 91 |
in comparison to the | 91 |
has been proposed to | 91 |
in the majority of | 91 |
study was to evaluate | 91 |
as described in the | 91 |
and characterization of the | 91 |
of type i ifns | 91 |
a final volume of | 90 |
the middle east respiratory | 90 |
was not detected in | 90 |
was approved by the | 90 |
the results of this | 90 |
was carried out in | 90 |
a high level of | 90 |
white spot syndrome virus | 90 |
been shown that the | 90 |
in the human genome | 90 |
mouse hepatitis virus strain | 90 |
plays a critical role | 90 |
samples were collected from | 90 |
to the production of | 90 |
c virus core protein | 90 |
spread of the virus | 90 |
data suggest that the | 89 |
the interaction of the | 89 |
in the respiratory tract | 89 |
of influenza a viruses | 89 |
were significantly higher in | 89 |
closely related to the | 89 |
systematic review and meta | 89 |
did not show any | 89 |
and cd t cells | 89 |
type i and type | 89 |
are summarized in table | 88 |
to a lesser extent | 88 |
the genome of the | 88 |
of tobacco mosaic virus | 88 |
in response to the | 88 |
of the most common | 88 |
detection and quantification of | 88 |
the detection of the | 88 |
by western blot analysis | 88 |
the presence of sars | 88 |
respiratory syncytial virus infection | 88 |
for the design of | 88 |
has been observed in | 88 |
patients with severe acute | 88 |
the host immune response | 87 |
cells were incubated with | 87 |
to better understand the | 87 |
appears to be a | 87 |
this is consistent with | 87 |
washed three times with | 87 |
has been identified as | 87 |
is present in the | 87 |
in terms of the | 87 |
is not essential for | 87 |
supplemented with fetal bovine | 87 |
g for min at | 86 |
from patients with pneumonia | 86 |
is similar to that | 86 |
one of the main | 86 |
amino acid sequence of | 86 |
could be detected in | 86 |
were used for the | 86 |
can be divided into | 86 |
in the viral genome | 86 |
in the detection of | 86 |
of hepatitis a virus | 86 |
hepatitis virus strain a | 86 |
the early phase of | 86 |
of gene expression in | 86 |
was found in the | 85 |
the early stage of | 85 |
to the cell surface | 85 |
that are involved in | 85 |
of hospitalized patients with | 85 |
after the onset of | 85 |
is considered to be | 85 |
can be used in | 85 |
is the most common | 84 |
are shown in table | 84 |
has been demonstrated to | 84 |
has been implicated in | 84 |
sensitivity and specificity of | 84 |
have been developed to | 84 |
amino acid sequences of | 84 |
was to evaluate the | 84 |
it is also possible | 84 |
tomato bushy stunt virus | 84 |
our results showed that | 84 |
in close proximity to | 84 |
to bind to the | 84 |
the molecular mechanisms of | 84 |
play a key role | 84 |
of cd t cells | 83 |
mutational analysis of the | 83 |
in relation to the | 83 |
as a positive control | 83 |
for the expression of | 83 |
compared to that of | 83 |
with hepatitis c virus | 83 |
the release of the | 83 |
in viral rna synthesis | 83 |
to the use of | 83 |
on the role of | 83 |
of an rna virus | 83 |
are listed in table | 83 |
origin and evolution of | 82 |
of the study was | 82 |
cells infected with the | 82 |
the study of the | 82 |
article is protected by | 82 |
for the use of | 82 |
we show that the | 82 |
the lack of a | 82 |
levels of viral rna | 82 |
is protected by copyright | 82 |
hospitalized patients with covid | 82 |
the virus life cycle | 82 |
a central role in | 82 |
on the expression of | 82 |
are shown in figure | 82 |
compared to the control | 82 |
this article is protected | 82 |
for the control of | 81 |
been shown to play | 81 |
the effects of the | 81 |
blood samples were collected | 81 |
and hepatitis c virus | 81 |
at different time points | 81 |
was significantly higher in | 81 |
in cell culture and | 81 |
for the analysis of | 81 |
shown to interact with | 81 |
at a multiplicity of | 81 |
has led to the | 81 |
total rna was isolated | 81 |
be used for the | 80 |
have a role in | 80 |
the performance of the | 80 |
to be important for | 80 |
and the cells were | 80 |
in order to identify | 80 |
have been implicated in | 80 |
the aim of our | 80 |
for h at room | 80 |
in the management of | 80 |
respiratory syndrome coronavirus nsp | 80 |
in cells transfected with | 80 |
of the presence of | 80 |
on the one hand | 79 |
is related to the | 79 |
the course of infection | 79 |
secondary structure of the | 79 |
similar results were obtained | 79 |
rna and dna viruses | 79 |
it was observed that | 79 |
as well as other | 79 |
a pivotal role in | 78 |
and the use of | 78 |
for the replication of | 78 |
of newcastle disease virus | 78 |
reverse transcription polymerase chain | 78 |
to be essential for | 78 |
the location of the | 78 |
it is interesting to | 78 |
did not affect the | 78 |
no significant differences in | 78 |
the inhibition of the | 78 |
using a combination of | 78 |
in an in vitro | 78 |
in view of the | 78 |
was added to each | 78 |
studies are required to | 78 |
viral rna was extracted | 78 |
have been identified as | 77 |
this suggests that the | 77 |
the herpes simplex virus | 77 |
previous studies have shown | 77 |
with the help of | 77 |
to the identification of | 77 |
of the number of | 77 |
was to determine the | 77 |
study was supported by | 77 |
have previously shown that | 77 |
structure of the sars | 77 |
that most of the | 77 |
these results demonstrate that | 77 |
but not in the | 77 |
in the synthesis of | 77 |
preprint the copyright holder | 77 |
a component of the | 77 |
in the induction of | 77 |
at the university of | 77 |
highly pathogenic avian influenza | 77 |
the development of novel | 77 |
to be responsible for | 76 |
into the host cell | 76 |
of viral rna and | 76 |
coronavirus associated with severe | 76 |
the relationship between the | 76 |
in each of the | 76 |
may be related to | 76 |
are present in the | 76 |
of japanese encephalitis virus | 76 |
of each of the | 76 |
type i interferon response | 76 |
shown in figure a | 76 |
a total of patients | 76 |
are responsible for the | 76 |
the west nile virus | 76 |
the detection of viral | 76 |
the coronavirus mouse hepatitis | 76 |
it is noteworthy that | 76 |
was extracted from the | 76 |
the regulation of the | 76 |
and middle east respiratory | 75 |
the coronavirus infectious bronchitis | 75 |
novel coronavirus associated with | 75 |
been shown to have | 75 |
of interferon regulatory factor | 75 |
the evolution of the | 75 |
of the dengue virus | 75 |
comparable to that of | 75 |
there is no evidence | 75 |
in line with the | 75 |
of the novel coronavirus | 75 |
in the nucleus and | 75 |
members of the genus | 75 |
for rapid detection of | 75 |
cells as well as | 75 |
and functional analysis of | 75 |
h n influenza a | 75 |
detection of novel coronavirus | 75 |
well as in the | 75 |
the mechanisms by which | 75 |
the possibility that the | 75 |
results show that the | 75 |
play a crucial role | 75 |
has been detected in | 74 |
this version posted september | 74 |
of the m protein | 74 |
of the spike protein | 74 |
the study was to | 74 |
to investigate the effect | 74 |
investigate the effect of | 74 |
the origin of the | 74 |
have no competing interests | 74 |
and it has been | 74 |
were identified in the | 74 |
in the vicinity of | 74 |
of patients with covid | 74 |
cells were cultured in | 74 |
can also be used | 74 |
a novel coronavirus associated | 74 |
at the cell surface | 74 |
in addition to its | 74 |
rna viruses such as | 74 |
of the nucleic acid | 74 |
h n influenza viruses | 74 |
crystal structure of a | 74 |
c virus ns a | 74 |
the potential role of | 74 |
the spike protein of | 73 |
alone or in combination | 73 |
there was a significant | 73 |
the structure and function | 73 |
and is associated with | 73 |
of avian infectious bronchitis | 73 |
may be associated with | 73 |
the cells were washed | 73 |
as well as by | 73 |
it is thought that | 73 |
in the design of | 73 |
one of the two | 73 |
is important for the | 73 |
the untranslated region of | 73 |
in the host cell | 73 |
with the presence of | 73 |
and adaptive immune responses | 73 |
is supported by a | 73 |
the objective of this | 73 |
internal ribosomal entry site | 73 |
in the viral life | 73 |
kindly provided by dr | 73 |
in vitro transcribed rna | 73 |
the best of our | 72 |
to the best of | 72 |
shown to be a | 72 |
key role in the | 72 |
may serve as a | 72 |
both dna and rna | 72 |
the efficiency of the | 72 |
are thought to be | 72 |
a systematic review and | 72 |
that the expression of | 72 |
best of our knowledge | 72 |
is part of the | 72 |
does not appear to | 72 |
in order to investigate | 72 |
of the cell cycle | 72 |
is believed to be | 72 |
and is required for | 72 |
they have no competing | 72 |
there is evidence that | 72 |
figure a and b | 72 |
incubated for min at | 72 |
outbreak associated with a | 72 |
in the endoplasmic reticulum | 72 |
used as a template | 72 |
hek t cells were | 72 |
foot and mouth disease | 72 |
it is believed that | 72 |
there were no significant | 72 |
be one of the | 72 |
of the type i | 72 |
untranslated region of the | 71 |
which is consistent with | 71 |
to the activation of | 71 |
associated with a new | 71 |
the viral genome and | 71 |
in viral replication and | 71 |
the identity of the | 71 |
over a period of | 71 |
of the genome and | 71 |
type i interferon production | 71 |
it was reported that | 71 |
assay for detection of | 71 |
hepatitis c virus in | 71 |
supported in part by | 71 |
plays a crucial role | 71 |
that the majority of | 71 |
a functional receptor for | 71 |
the impact of the | 71 |
in spite of the | 71 |
in the generation of | 71 |
at the site of | 71 |
the s protein of | 71 |
as the number of | 71 |
a part of the | 71 |
has yet to be | 71 |
increase in the number | 71 |
for severe acute respiratory | 71 |
one of the first | 71 |
a retrospective cohort study | 71 |
of the central nervous | 71 |
is shown in figure | 71 |
by agarose gel electrophoresis | 71 |
terminal domain of the | 70 |
a new coronavirus of | 70 |
for their ability to | 70 |
version of this article | 70 |
in a recent study | 70 |
viral rna synthesis and | 70 |
the national institutes of | 70 |
with the development of | 70 |
this version posted august | 70 |
with a new coronavirus | 70 |
that the number of | 70 |
pneumonia outbreak associated with | 70 |
epidermal growth factor receptor | 70 |
a pneumonia outbreak associated | 70 |
in the present work | 70 |
west nile virus infection | 70 |
in order to evaluate | 70 |
the integrity of the | 70 |
see materials and methods | 70 |
did not result in | 70 |
new coronavirus of probable | 70 |
a significant decrease in | 70 |
included in this study | 70 |
the first time that | 70 |
of probable bat origin | 70 |
to be required for | 70 |
coronavirus of probable bat | 70 |
cells were seeded in | 70 |
crucial role in the | 70 |
are consistent with the | 69 |
the results show that | 69 |
production of type i | 69 |
regulate the expression of | 69 |
in influenza a virus | 69 |
play a critical role | 69 |
cells were grown in | 69 |
room temperature for min | 69 |
a significant role in | 69 |
for up to days | 69 |
in the assembly of | 69 |
a major cause of | 69 |
it was demonstrated that | 69 |
for viral replication and | 69 |
be found in the | 69 |
was obtained from the | 69 |
was reported to be | 69 |
is similar to the | 69 |
referred to as the | 69 |
of genes involved in | 69 |
for a total of | 69 |
functional analysis of the | 69 |
for the detection and | 69 |
is located in the | 69 |
role in the regulation | 69 |
to the discovery of | 69 |
cells were fixed with | 68 |
with regard to jurisdictional | 68 |
the large number of | 68 |
maps and institutional affiliations | 68 |
springer nature remains neutral | 68 |
remains neutral with regard | 68 |
was carried out by | 68 |
is closely related to | 68 |
nature remains neutral with | 68 |
in a patient with | 68 |
in chronic hepatitis c | 68 |
have also been reported | 68 |
at least in part | 68 |
inhibit the replication of | 68 |
in the genomes of | 68 |
neutral with regard to | 68 |
of the viral life | 68 |
regard to jurisdictional claims | 68 |
of the h n | 68 |
by in vitro transcription | 68 |
prevention and treatment of | 68 |
viral rna replication and | 68 |
the start of the | 68 |
performed as previously described | 68 |
and severe acute respiratory | 68 |
response to viral infection | 68 |
the results suggest that | 68 |
required for viral replication | 68 |
mitochondrial antiviral signaling protein | 67 |
published maps and institutional | 67 |
were used in the | 67 |
was significantly higher than | 67 |
in published maps and | 67 |
our aim was to | 67 |
to jurisdictional claims in | 67 |
cells transfected with the | 67 |
claims in published maps | 67 |
influenza a virus infection | 67 |
phylogenetic analysis of the | 67 |
jurisdictional claims in published | 67 |
due to the high | 67 |
this version posted june | 67 |
the polymerase chain reaction | 67 |
despite the fact that | 67 |
a new class of | 67 |
the viral genomic rna | 67 |
in the level of | 67 |
of the nucleocapsid protein | 66 |
safety and efficacy of | 66 |
of dna and rna | 66 |
of viral rna replication | 66 |
the absence of any | 66 |
an increasing number of | 66 |
were performed using the | 66 |
infected with novel coronavirus | 66 |
the type i ifn | 66 |
as well as with | 66 |
in an effort to | 66 |
clinical features of patients | 66 |
were washed three times | 66 |
of the creative commons | 66 |
the immune response to | 66 |
the creative commons attribution | 66 |
been shown to inhibit | 66 |
distributed under the terms | 66 |
an equal volume of | 66 |
objective of this study | 66 |
in this work we | 66 |
a single amino acid | 66 |
of one of the | 66 |
the onset of symptoms | 66 |
the average number of | 66 |
at a dose of | 66 |
molecular biology of coronaviruses | 66 |
has been reported in | 66 |
to determine if the | 66 |
further studies are needed | 66 |
for the inhibition of | 66 |
the host response to | 65 |
is yet to be | 65 |
and can be used | 65 |
the s ribosomal subunit | 65 |
blood and blood products | 65 |
patients with pneumonia in | 65 |
the efficacy and safety | 65 |
that the use of | 65 |
the open reading frame | 65 |
response to virus infection | 65 |
the viral replication cycle | 65 |
we are grateful to | 65 |
the largest rna virus | 65 |
the cytoplasm of infected | 65 |
ns a and ns | 65 |
due to the fact | 65 |
the synthesis of a | 65 |
national center for biotechnology | 65 |
of the plasma membrane | 65 |
are one of the | 65 |
to a final concentration | 65 |
coronavirus from patients with | 65 |
in the lungs of | 65 |
for the majority of | 65 |
as well as their | 65 |
in the recognition of | 65 |
cd t cell responses | 65 |
to the number of | 65 |
a consequence of the | 65 |
have been observed in | 65 |
novel coronavirus from patients | 65 |
of small interfering rna | 65 |
interesting to note that | 65 |
in most of the | 65 |
of our study was | 65 |
the number of reads | 65 |
of viral nucleic acids | 65 |
in cells treated with | 65 |
on the day of | 64 |
the s and s | 64 |
in the study of | 64 |
different regions of the | 64 |
of reactive oxygen species | 64 |
the genome sequence of | 64 |
a novel coronavirus in | 64 |
report of the international | 64 |
by polymerase chain reaction | 64 |
at room temperature and | 64 |
be noted that the | 64 |
the production of infectious | 64 |
significant difference in the | 64 |
to note that the | 64 |
the national institute of | 64 |
were carried out in | 64 |
of classical swine fever | 64 |
the middle of the | 64 |
respiratory syndrome coronavirus in | 64 |
in the last years | 64 |
the nucleotide sequence of | 64 |
with pneumonia in china | 64 |
is also possible that | 64 |
nucleotide and amino acid | 64 |
be detected in the | 64 |
have been developed for | 64 |
aim of our study | 64 |
the virus in the | 64 |
this study was supported | 64 |
limit of detection of | 64 |
positive strand rna viruses | 63 |
of porcine epidemic diarrhea | 63 |
the determination of the | 63 |
role in the pathogenesis | 63 |
of the in vitro | 63 |
the viral rna genome | 63 |
it is well known | 63 |
of the amino acid | 63 |
region of the genome | 63 |
we were unable to | 63 |
by binding to the | 63 |
viral load in the | 63 |
these results indicated that | 63 |
more than of the | 63 |
and the expression of | 63 |
to play an important | 63 |
is interesting to note | 63 |
in order to obtain | 63 |
used to evaluate the | 63 |
with novel coronavirus in | 63 |
presence of viral rna | 63 |
has been reported for | 63 |
been implicated in the | 63 |
has been suggested to | 63 |
patients infected with novel | 63 |
play an essential role | 63 |
have been described in | 63 |
could be used for | 63 |
in one of the | 63 |
progress has been made | 63 |
at least one of | 63 |
a mutation in the | 62 |
was also detected in | 62 |
can be applied to | 62 |
was used to detect | 62 |
of the use of | 62 |
seems to be a | 62 |
upper and lower respiratory | 62 |
replication of the viral | 62 |
features of patients infected | 62 |
reduce the risk of | 62 |
authors would like to | 62 |
as is the case | 62 |
the viral rna polymerase | 62 |
as an internal control | 62 |
is used as a | 62 |
play a major role | 62 |
in the middle of | 62 |
to the host cell | 62 |
in this study was | 62 |
the crystal structures of | 62 |
for the induction of | 62 |
induce the formation of | 62 |
the members of the | 62 |
is the first report | 62 |
with a history of | 62 |
or in combination with | 62 |
in the serum of | 62 |
the national center for | 62 |
is critical for the | 62 |
assay for the detection | 61 |
the past few years | 61 |
from the nucleus to | 61 |
the level of the | 61 |
in the inhibition of | 61 |
and activator of transcription | 61 |
the coding region of | 61 |
significant differences in the | 61 |
cytoplasm of infected cells | 61 |
it is conceivable that | 61 |
included in the study | 61 |
which is essential for | 61 |
not included in the | 61 |
for a variety of | 61 |
the plasma membrane of | 61 |
of the interaction between | 61 |
the relative abundance of | 61 |
of blood and blood | 61 |
article distributed under the | 61 |
innate and adaptive immunity | 61 |
at the molecular level | 61 |
by the innate immune | 61 |
can be explained by | 61 |
it was suggested that | 61 |
this version posted may | 61 |
small cell lung cancer | 61 |
the results indicate that | 61 |
the understanding of the | 61 |
is a potent inhibitor | 61 |
the viral genome is | 61 |
this is the case | 61 |
transducer and activator of | 61 |
plays an essential role | 61 |
as part of a | 61 |
and incubated for h | 61 |
the lower respiratory tract | 61 |
for a number of | 60 |
a negative regulator of | 60 |
to ensure that the | 60 |
the antiviral effects of | 60 |
in balb c mice | 60 |
not appear to be | 60 |
sars coronavirus nucleocapsid protein | 60 |
online version of this | 60 |
have been proposed to | 60 |
to interfere with the | 60 |
a reduction in the | 60 |
mode of action of | 60 |
were no significant differences | 60 |
of red blood cells | 60 |
each of the three | 60 |
it is worth noting | 60 |
was not associated with | 60 |
major role in the | 60 |
avian coronavirus infectious bronchitis | 60 |
we have demonstrated that | 60 |
the viral replication complex | 60 |
an overview of the | 60 |
as in the case | 60 |
no effect on the | 60 |
of the coronavirus mouse | 60 |
a h n virus | 60 |
is a functional receptor | 60 |
for a long time | 60 |
the pcr products were | 60 |
the authors would like | 60 |
has been used in | 60 |
the molecular mechanism of | 60 |
the online version of | 60 |
hepatitis c virus and | 60 |
as shown in table | 60 |
was similar to that | 60 |
induction of type i | 60 |
critically ill patients with | 59 |
also been reported to | 59 |
strand rna virus replication | 59 |
during the study period | 59 |
university school of medicine | 59 |
test was used to | 59 |
was associated with a | 59 |
chronic hepatitis c virus | 59 |
we conclude that the | 59 |
have the ability to | 59 |
access article distributed under | 59 |
active site of the | 59 |
was isolated from the | 59 |
signal transducer and activator | 59 |
used for the detection | 59 |
is well known that | 59 |
and the production of | 59 |
the mechanism of the | 59 |
by severe acute respiratory | 59 |
a low level of | 59 |
that are able to | 59 |
to an increase in | 59 |
the exception of the | 59 |
in hek t cells | 59 |
replication of the virus | 59 |
in a previous study | 59 |
of type i interferons | 59 |
our study was to | 59 |
and clinical characteristics of | 59 |
the most commonly used | 59 |
plays a major role | 59 |
binding domain of the | 59 |
supported by grants from | 59 |
we have found that | 59 |
s in supplementary material | 59 |
that some of the | 58 |
center for biotechnology information | 58 |
regions of the genome | 58 |
heterogeneous nuclear ribonucleoprotein a | 58 |
used to assess the | 58 |
were carried out using | 58 |
rna was extracted using | 58 |
the center of the | 58 |
added to each well | 58 |
for the determination of | 58 |
with the addition of | 58 |
was supported by grants | 58 |
be the result of | 58 |
that are associated with | 58 |
as an alternative to | 58 |
is worth noting that | 58 |
compared with the control | 58 |
patients infected with sars | 58 |
of chronic hepatitis c | 58 |
the most widely used | 58 |
proteolytic processing of the | 58 |
the distribution of the | 58 |
of nsp and nsp | 58 |
have also been shown | 58 |
type i ifn signaling | 58 |
study was designed to | 58 |
of novel coronavirus pneumonia | 58 |
in the early s | 58 |
i and type ii | 58 |
reverse genetics system for | 58 |
the sequences of the | 58 |
which is involved in | 58 |
a change in the | 58 |
of the viral replication | 58 |
was also found to | 58 |
of the influenza a | 58 |
were used to determine | 58 |
diagnosis and treatment of | 58 |
the host immune system | 58 |
was found that the | 58 |
we also found that | 58 |
the treatment of patients | 58 |
by a combination of | 57 |
our data show that | 57 |
analysis of the sars | 57 |
to be used as | 57 |
the extent to which | 57 |
were incubated for h | 57 |
the virus and the | 57 |
performed as described previously | 57 |
as a source of | 57 |
in the upper respiratory | 57 |
the severity of the | 57 |
coding region of the | 57 |
replication and transcription of | 57 |
of the viral proteins | 57 |
replication of hepatitis c | 57 |
the treatment of sars | 57 |
the generation of a | 57 |
aim of the present | 57 |
were included in this | 57 |
will be required to | 57 |
in comparison with the | 57 |
novel coronavirus in wuhan | 57 |
likely due to the | 57 |
for the purpose of | 57 |
without the need for | 57 |
for the discovery of | 57 |
respiratory syndrome coronavirus replication | 57 |
infectious bursal disease virus | 57 |
in the infected cells | 57 |
of mutations in the | 57 |
a comparison of the | 57 |
of the active site | 57 |
the sensitivity and specificity | 57 |
cells in response to | 57 |
in health and disease | 57 |
the purpose of the | 57 |
was used in the | 57 |
hepatitis b virus infection | 57 |
the development of an | 57 |
the nuclear pore complex | 57 |
and the absence of | 57 |
it has been found | 57 |
be used as an | 57 |
of borna disease virus | 57 |
is likely that the | 57 |
was shown that the | 57 |
expression of type i | 56 |
has been described in | 56 |
the gene of interest | 56 |
could be used as | 56 |
based on these results | 56 |
influenza a virus ns | 56 |
the cells were incubated | 56 |
antiviral innate immune response | 56 |
of the effect of | 56 |
have been demonstrated to | 56 |
we did not observe | 56 |
by grants from the | 56 |
in the diagnosis of | 56 |
specific cd t cells | 56 |
we have investigated the | 56 |
the core of the | 56 |
there is a need | 56 |
with acute respiratory distress | 56 |
is located at the | 56 |
read and approved the | 56 |
there was no difference | 56 |
with regard to the | 56 |
was identified as a | 56 |
coronavirus ribosomal frameshifting signal | 56 |
replication by rna interference | 56 |
entry into host cells | 56 |
in human immunodeficiency virus | 56 |
at different stages of | 56 |
cd t cells in | 56 |
we sought to determine | 56 |
member of the family | 56 |
with the plasma membrane | 56 |
treatment of chronic hepatitis | 56 |
in the supplemental material | 56 |
in the region of | 56 |
involved in the formation | 56 |
essential for viral replication | 56 |
and the lack of | 55 |
in the amount of | 55 |
results of this study | 55 |
in the cytoplasm and | 55 |
was supported by a | 55 |
the scope of this | 55 |
at the surface of | 55 |
of viral gene expression | 55 |
gene expression in the | 55 |
genome sequence of the | 55 |
of viral nucleic acid | 55 |
are required for the | 55 |
inhibits the replication of | 55 |
is also involved in | 55 |
would be expected to | 55 |
pcr was performed using | 55 |
a and b viruses | 55 |
to the site of | 55 |
in the levels of | 55 |
in the face of | 55 |
of host protein synthesis | 55 |
and approved the final | 55 |
time polymerase chain reaction | 55 |
on the development of | 55 |
the hepatitis e virus | 55 |
treatment of patients with | 55 |
was kindly provided by | 55 |
expression in response to | 55 |
as a target for | 55 |
in the identification of | 55 |
to be present in | 55 |
dependent rna polymerase of | 55 |
are associated with the | 55 |
has been used for | 55 |
these results show that | 55 |
the host innate immune | 55 |
to further investigate the | 55 |
and the effect of | 55 |
and the formation of | 55 |
it was possible to | 55 |
been identified as a | 55 |
the treatment of chronic | 54 |
the production of a | 54 |
of differentially expressed genes | 54 |
is the case for | 54 |
the hepatitis b virus | 54 |
in order to prevent | 54 |
in the same way | 54 |
at a density of | 54 |
to act as a | 54 |
the identification of a | 54 |
is in agreement with | 54 |
parts of the world | 54 |
might be due to | 54 |
virus replication in the | 54 |
resulted in a significant | 54 |
has been found that | 54 |
is the use of | 54 |
regulates the expression of | 54 |
used to study the | 54 |
cells were fixed and | 54 |
determine the effect of | 54 |
a powerful tool for | 54 |
of bovine viral diarrhea | 54 |
the difference between the | 54 |
over the course of | 54 |
been suggested that the | 54 |
been shown to interact | 54 |
and phylogenetic analysis of | 54 |
incubated at room temperature | 54 |
with that of the | 54 |
coronavirus in patients with | 54 |
statistical analysis was performed | 54 |
was used to identify | 54 |
in this study are | 54 |
for the activation of | 54 |
development and evaluation of | 54 |
identification of a new | 54 |
type i interferon signaling | 54 |
through the use of | 54 |
to test this hypothesis | 54 |
of the viral envelope | 54 |
one or more of | 54 |
were present in the | 54 |
the present study we | 54 |
has been used as | 53 |
investigate the role of | 53 |
the n protein of | 53 |
the gene encoding the | 53 |
to the generation of | 53 |
it has recently been | 53 |
which can be used | 53 |
the product of the | 53 |
at an early stage | 53 |
the presence of mg | 53 |
by the immune system | 53 |
results indicated that the | 53 |
in a final volume | 53 |
was performed on the | 53 |
would be interesting to | 53 |
of brome mosaic virus | 53 |
the presence of these | 53 |
in the release of | 53 |
the nucleus to the | 53 |
respiratory tract infections in | 53 |
to be related to | 53 |
in order to understand | 53 |
in the nucleus of | 53 |
has been made in | 53 |
detection and characterization of | 53 |
cells were maintained in | 53 |
it would be interesting | 53 |
the ends of the | 53 |
the cells were then | 53 |
the structure of a | 53 |
is a prerequisite for | 53 |
it will be interesting | 53 |
is defined as the | 53 |
to determine the effect | 53 |
was found to have | 53 |
from the plasma membrane | 53 |
probably due to the | 53 |
and expression of the | 53 |
which is known to | 53 |
our data indicate that | 53 |
present study was to | 53 |
at g for min | 53 |
been proposed to be | 53 |
these data demonstrate that | 52 |
functional receptor for the | 52 |
performed according to the | 52 |
more likely to be | 52 |
the presence of virus | 52 |
of zika virus in | 52 |
and its role in | 52 |
in a wide range | 52 |
were washed twice with | 52 |
protein of severe acute | 52 |
the qiaamp viral rna | 52 |
are located in the | 52 |
cells were incubated for | 52 |
for the prevention of | 52 |
it is tempting to | 52 |
in all of the | 52 |
an increased risk of | 52 |
cell leukemia virus type | 52 |
into the host genome | 52 |
terminal region of the | 52 |
used as a control | 52 |
was performed according to | 52 |
has been found in | 52 |
with a variety of | 52 |
a potential target for | 52 |
samples from patients with | 52 |
mouse hepatitis virus a | 52 |
was estimated to be | 52 |
this version posted july | 52 |
results are consistent with | 52 |
the complexity of the | 52 |
of innate immune responses | 52 |
the free energy of | 52 |
transcription and replication of | 52 |
open reading frame of | 52 |
gene expression and replication | 52 |
are essential for the | 52 |
of rna secondary structure | 52 |
of a series of | 52 |
from the endoplasmic reticulum | 52 |
carried out in a | 51 |
has been demonstrated in | 51 |
for the initiation of | 51 |
the region of the | 51 |
may be responsible for | 51 |
the genomic rna of | 51 |
be attributed to the | 51 |
are more likely to | 51 |
have been linked to | 51 |
mechanisms of action of | 51 |
was supported in part | 51 |
not present in the | 51 |
does not seem to | 51 |
viruses belonging to the | 51 |
will be interesting to | 51 |
de groot et al | 51 |
in vitro selection of | 51 |
hepatitis b surface antigen | 51 |
found to be the | 51 |
southern bean mosaic virus | 51 |
epidemiology of novel coronavirus | 51 |
further studies are required | 51 |
for the management of | 51 |
amino acids of the | 51 |
the therapeutic potential of | 51 |
c for min and | 51 |
to the release of | 51 |
hepatitis c virus nonstructural | 51 |
compared to those of | 51 |
in vitro translation of | 51 |
was determined to be | 51 |
for the delivery of | 51 |
ebola and marburg viruses | 51 |
on the number of | 51 |
on the mechanism of | 50 |
region of the viral | 50 |
which is available to | 50 |
was carried out with | 50 |
protein is required for | 50 |
were significantly higher than | 50 |
a portion of the | 50 |
for virus origins and | 50 |
largest rna virus genome | 50 |
the possible role of | 50 |
virus origins and receptor | 50 |
hepatitis b virus replication | 50 |
essential for virus replication | 50 |
genes involved in the | 50 |
in the human population | 50 |
when compared with the | 50 |
innate immune response by | 50 |
as the gene source | 50 |
might be involved in | 50 |
to the control group | 50 |
in the plasma membrane | 50 |
cd t cells and | 50 |
the goal of this | 50 |
the synthesis of viral | 50 |
and functional characterization of | 50 |
coronaviruses as the gene | 50 |
the leading cause of | 50 |
and epidemiology of novel | 50 |
in order to study | 50 |
the case of a | 50 |
were incubated with the | 50 |
the gene source of | 50 |
are among the most | 50 |
as a loading control | 50 |
will be discussed in | 50 |
the production of the | 50 |
in peripheral blood mononuclear | 50 |
the ratio of the | 50 |
has been identified in | 50 |
implications for virus origins | 50 |
of the ebola virus | 50 |
in the immune response | 50 |
in addition to these | 50 |
was also observed in | 50 |
origins and receptor binding | 50 |
regions of the viral | 50 |
in the early stages | 50 |
the cells were harvested | 50 |
the porcine reproductive and | 50 |
on the type of | 50 |
have yet to be | 50 |
of rna viruses in | 50 |
minutes at room temperature | 50 |
was performed with the | 50 |
to the surface of | 50 |
a vital role in | 50 |
approved for the treatment | 50 |
evs were isolated from | 50 |
which is required for | 50 |
the inhibitory effects of | 50 |
the adaptive immune response | 50 |
for viral rna synthesis | 50 |
to the inhibition of | 50 |
the centers for disease | 50 |
associated with an increased | 50 |
of the expression of | 49 |
experiments were performed in | 49 |
taking into account the | 49 |
or more of the | 49 |
available to authorized users | 49 |
the addition of a | 49 |
cause of severe acute | 49 |
with the number of | 49 |
fluorescence resonance energy transfer | 49 |
hepatitis b and c | 49 |
the viral load in | 49 |
and is blocked by | 49 |
for in vitro transcription | 49 |
in a similar manner | 49 |
which is responsible for | 49 |
viral replication and transcription | 49 |
understanding of the molecular | 49 |
as well as an | 49 |
this is due to | 49 |
of the human immunodeficiency | 49 |
the a and b | 49 |
may be important for | 49 |
to the viral rna | 49 |
the formation of an | 49 |
in our understanding of | 49 |
is determined by the | 49 |
and specificity of the | 49 |
the loss of the | 49 |
of allergy and infectious | 49 |
the difference in the | 49 |
entry into the host | 49 |
and lower respiratory tract | 49 |
is blocked by a | 49 |
in addition to this | 49 |
american type culture collection | 49 |
of cd and cd | 49 |
can lead to the | 49 |
had no role in | 49 |
in the setting of | 49 |
that are essential for | 49 |
can be considered as | 49 |
the top of the | 49 |
considered to be a | 49 |
a total volume of | 49 |
in vivo delivery of | 49 |
by the lack of | 49 |
in viral rna replication | 49 |
data indicate that the | 49 |
by small interfering rnas | 49 |
shed light on the | 49 |
has been applied to | 49 |
of rift valley fever | 49 |
in order to achieve | 49 |
the jak stat pathway | 49 |
the absence or presence | 49 |
the duration of the | 49 |
is available to authorized | 49 |
with the aim of | 49 |
this version posted april | 49 |
a function of the | 49 |
these results suggested that | 49 |
of the endoplasmic reticulum | 49 |
and respiratory syncytial virus | 49 |
the addition of the | 49 |
respiratory syndrome coronavirus and | 49 |
transcriptase polymerase chain reaction | 49 |
study was approved by | 49 |
significantly higher than that | 49 |
the amino acid sequences | 49 |
a nested set of | 49 |
of viral replication and | 48 |
remains to be elucidated | 48 |
here we show that | 48 |
a novel class of | 48 |
the safety and efficacy | 48 |
the ns a protein | 48 |
the first report of | 48 |
and in some cases | 48 |
can serve as a | 48 |
proteins involved in the | 48 |
nucleus to the cytoplasm | 48 |
aimed to investigate the | 48 |
to the active site | 48 |
are found in the | 48 |
ace and tmprss and | 48 |
entry depends on ace | 48 |
is composed of a | 48 |
absence or presence of | 48 |
in humans and animals | 48 |
in vitro antiviral activity | 48 |
of the effects of | 48 |
due to lack of | 48 |
and west nile virus | 48 |
cell entry depends on | 48 |
in the peripheral blood | 48 |
with an increase in | 48 |
on ace and tmprss | 48 |
detect the presence of | 48 |
was determined by the | 48 |
and tmprss and is | 48 |
of novel coronavirus in | 48 |
reticulovesicular network of modified | 48 |
been used as a | 48 |
in the presence and | 48 |
in patients infected with | 48 |
cells were washed twice | 48 |
a number of different | 48 |
depends on ace and | 48 |
can be achieved by | 48 |
transmission of the virus | 48 |
for the preparation of | 48 |
is referred to as | 48 |
associated with acute respiratory | 48 |
at c for min | 48 |
makes it possible to | 48 |
was not affected by | 48 |
inhibition of hepatitis c | 48 |
the conformation of the | 48 |
critical role in the | 48 |
dependent rna polymerase and | 48 |
with the ability to | 48 |
is associated with an | 48 |
also been found to | 48 |
a review of the | 48 |
may play an important | 48 |
by a variety of | 48 |
is associated with increased | 48 |
type i interferon induction | 48 |
early stages of infection | 47 |
blocked by a clinically | 47 |
the rough endoplasmic reticulum | 47 |
was not due to | 47 |
and replication of the | 47 |
to the pathogenesis of | 47 |
expression in mammalian cells | 47 |
of the th century | 47 |
by interacting with the | 47 |
experiments were carried out | 47 |
was based on the | 47 |
defective interfering particles of | 47 |
of three independent experiments | 47 |
tmprss and is blocked | 47 |
analysis revealed that the | 47 |
approved the final manuscript | 47 |
it is essential to | 47 |
innate immune responses to | 47 |
a clinically proven protease | 47 |
t cells in the | 47 |
be considered as a | 47 |
cells were incubated at | 47 |
by a clinically proven | 47 |
protein is involved in | 47 |
was performed as previously | 47 |
red clover necrotic mosaic | 47 |
structural and accessory proteins | 47 |
the accuracy of the | 47 |
and the level of | 47 |
in combination with a | 47 |
the complete nucleotide sequence | 47 |
to be due to | 47 |
on ice for min | 47 |
there were no differences | 47 |
the evolutionary history of | 47 |
it is not possible | 47 |
are the most common | 47 |
it was concluded that | 47 |
the efficacy of the | 47 |
institute of allergy and | 47 |
with a mixture of | 47 |
the properties of the | 47 |
and evaluation of a | 47 |
by nanoparticle tracking analysis | 47 |
member of the genus | 47 |
its interaction with the | 47 |
been shown to bind | 47 |
on the host cell | 47 |
in response to virus | 47 |
an infectious cdna clone | 47 |
the expression of genes | 47 |
to the emergence of | 47 |
in vitro transcription of | 47 |
be used to identify | 47 |
of some of the | 47 |
the cells were fixed | 47 |
we propose that the | 47 |
is likely due to | 47 |
shown to play a | 47 |
in infected cells and | 47 |
the production of type | 47 |
of type i and | 47 |
to the expression of | 47 |
h n avian influenza | 47 |
at the expense of | 47 |
the enzymatic activity of | 47 |
has also been observed | 47 |
in combination with other | 47 |
has been linked to | 47 |
animal care and use | 47 |
also play a role | 47 |
internal initiation of translation | 47 |
through the activation of | 47 |
this may be due | 47 |
we observed that the | 47 |
to the study of | 47 |
carried out in the | 47 |
to hepatitis c virus | 47 |
national institute of allergy | 47 |
have been reported for | 47 |
here we report the | 47 |
that is required for | 47 |
respiratory syndrome coronavirus nucleocapsid | 47 |
novel coronavirus in patients | 47 |
the protein data bank | 47 |
was significantly lower in | 47 |
the expression of these | 47 |
the detection limit of | 47 |
clinically proven protease inhibitor | 46 |
in the innate immune | 46 |
host innate immune response | 46 |
confirmed the presence of | 46 |
and the ability to | 46 |
could not be detected | 46 |
is caused by a | 46 |
it was proposed that | 46 |
of h n influenza | 46 |
of the rna genome | 46 |
the results of these | 46 |
have demonstrated that the | 46 |
the influence of the | 46 |
as the template for | 46 |
moloney murine leukemia virus | 46 |
with the fact that | 46 |
are included in the | 46 |
for the evaluation of | 46 |
used in the treatment | 46 |
presence and absence of | 46 |
and their role in | 46 |
of influenza a and | 46 |
leads to the formation | 46 |
genomic characterisation and epidemiology | 46 |
which has been shown | 46 |
virological assessment of hospitalized | 46 |
initiation of rna synthesis | 46 |
is a component of | 46 |
authors read and approved | 46 |
these observations suggest that | 46 |
human rhinovirus c protease | 46 |
our results demonstrate that | 46 |
for the construction of | 46 |
detection of influenza a | 46 |
it has been observed | 46 |
the frequency of the | 46 |
were more likely to | 46 |
a systematic review of | 46 |
a molecular weight of | 46 |
used for statistical analysis | 46 |
that are required for | 46 |
has not been reported | 46 |
crystal structures of the | 46 |
in the absence or | 46 |
of rna secondary structures | 46 |
the design of the | 46 |
investigate the effects of | 46 |
was also shown to | 46 |
all members of the | 46 |
due to the low | 46 |
close proximity to the | 46 |
spike protein of sars | 46 |
new coronavirus associated with | 46 |
as well as its | 46 |
the composition of the | 46 |
is a multifunctional protein | 46 |
a number of other | 46 |
is not possible to | 46 |
shown to be involved | 46 |
guanine nucleotide exchange factor | 46 |
and an increase in | 46 |
with the formation of | 46 |
be associated with the | 46 |
be used to detect | 46 |
the first step in | 46 |
characterisation and epidemiology of | 46 |
the amount of viral | 46 |
at a final concentration | 46 |
has proven to be | 46 |
antiviral activity of the | 46 |
also found to be | 46 |
compared to the wild | 46 |
a large proportion of | 46 |
significant difference between the | 46 |
it is not surprising | 46 |
a total of samples | 46 |
by the end of | 46 |
used for the treatment | 46 |
and evolution of the | 46 |
a new coronavirus associated | 46 |
of modified endoplasmic reticulum | 45 |
the viruses and their | 45 |
even in the absence | 45 |
patients with coronavirus disease | 45 |
were infected with the | 45 |
the first step of | 45 |
conserved features of genome | 45 |
of the respiratory tract | 45 |
the vesicular stomatitis virus | 45 |
by rna polymerase ii | 45 |
infected or infected with | 45 |
of reads mapping to | 45 |
of genome and proteome | 45 |
of the west nile | 45 |
have been used for | 45 |
unique and conserved features | 45 |
essential role in the | 45 |
the emergence of the | 45 |
the first and second | 45 |
against hepatitis c virus | 45 |
a reticulovesicular network of | 45 |
the role of this | 45 |
in order to increase | 45 |
type i ifn response | 45 |
is the number of | 45 |
the translation of the | 45 |
was used to assess | 45 |
this indicates that the | 45 |
of the target gene | 45 |
and conserved features of | 45 |
for viral rna replication | 45 |
of the e protein | 45 |
translation initiation factor eif | 45 |
isolation of a novel | 45 |
the coronavirus group lineage | 45 |
fusion of the viral | 45 |
conformational changes in the | 45 |
of the flaviviridae family | 45 |
based on the use | 45 |
of the structural proteins | 45 |
is an open access | 45 |
features of genome and | 45 |
been identified in the | 45 |
an inhibitor of the | 45 |
in response to viral | 45 |
from each of the | 45 |
open access article distributed | 45 |
the result of a | 45 |
tempting to speculate that | 45 |
network of modified endoplasmic | 45 |
which are involved in | 45 |
influenza a virus in | 45 |
is derived from the | 45 |
the presence of mm | 45 |
of viruses in the | 45 |
which is associated with | 45 |
type i and iii | 45 |
do not appear to | 45 |
which leads to the | 45 |
genome and proteome of | 45 |
the result of the | 45 |
the characterization of the | 45 |
the remainder of the | 45 |
over the last years | 45 |
the h n virus | 45 |
can be seen in | 45 |
for minutes at room | 45 |
to investigate the role | 45 |
of the unfolded protein | 45 |
was used as an | 45 |
infectious cdna clone of | 45 |
characteristics of cases of | 45 |
is not known whether | 45 |
before and after the | 45 |
carried out using the | 45 |
the cytoplasm of the | 45 |
the internal ribosome entry | 45 |
an open access article | 45 |
were also detected in | 45 |
it is unlikely that | 45 |
were carried out with | 45 |
it is unclear whether | 45 |
from the coronavirus group | 45 |
study the effect of | 45 |
been shown to induce | 45 |
care and use committee | 45 |
off from the coronavirus | 44 |
activation of rnase l | 44 |
in the use of | 44 |
a risk factor for | 44 |
t rna polymerase promoter | 44 |
were not significantly different | 44 |
virus in cell culture | 44 |
appears to be the | 44 |
coronavirus nonstructural protein nsp | 44 |
been suggested to be | 44 |
the development of antiviral | 44 |
genome replication and transcription | 44 |
as a tool for | 44 |
to a decrease in | 44 |
not seem to be | 44 |
and a number of | 44 |
resuspended in ml of | 44 |
to be effective in | 44 |
a template for the | 44 |
the catalytic activity of | 44 |
to the absence of | 44 |
titers were determined by | 44 |
formation of stress granules | 44 |
at each time point | 44 |
in the liver and | 44 |
inhibition of hepatitis b | 44 |
a and ns b | 44 |
the last few years | 44 |
dependent rna polymerase activity | 44 |
of the viral mrna | 44 |
of mice infected with | 44 |
influenza a virus replication | 44 |
lower respiratory tract infections | 44 |
on the nature of | 44 |
have been suggested to | 44 |
of one or more | 44 |
is crucial for the | 44 |
with chronic hepatitis b | 44 |
the genetic diversity of | 44 |
with the host cell | 44 |
c virus ns b | 44 |
we showed that the | 44 |
of p and p | 44 |
strand rna viruses and | 44 |
in the modulation of | 44 |
it may be possible | 44 |
the n protein is | 44 |
our findings suggest that | 44 |
respiratory syndrome coronavirus spike | 44 |
were transfected with the | 44 |
rna synthesis by the | 44 |
is not well understood | 44 |
one of the three | 44 |
identical to that of | 44 |
the discovery of the | 44 |
genome sequence of a | 44 |
for min followed by | 44 |
and to a lesser | 44 |
will be needed to | 44 |
was also used to | 44 |
than those of the | 44 |
reading of the manuscript | 44 |
is not fully understood | 44 |
respiratory syndrome coronavirus nonstructural | 44 |
with the novel coronavirus | 44 |
note springer nature remains | 43 |
the absence of an | 43 |
play a pivotal role | 43 |
in the brains of | 43 |
the intensity of the | 43 |
in order to be | 43 |
were found to have | 43 |
leading to the formation | 43 |
dependent on the presence | 43 |
mediated by the viral | 43 |
novel coronavirus from a | 43 |
genomic and subgenomic rna | 43 |
single open reading frame | 43 |
that there is no | 43 |
in the spike protein | 43 |
mouse hepatitis virus rna | 43 |
rna secondary structure prediction | 43 |
replicate in the cytoplasm | 43 |
these data show that | 43 |
the helicase activity of | 43 |
the establishment of a | 43 |
of the infected cells | 43 |
in order to avoid | 43 |
is characterized by a | 43 |
upper respiratory tract infections | 43 |
cell culture and in | 43 |
in hospitalized patients with | 43 |
the results of our | 43 |
of the capsid protein | 43 |
with feline infectious peritonitis | 43 |
the production of ifn | 43 |
innate immune response in | 43 |
fever with renal syndrome | 43 |
of gene expression by | 43 |
will be necessary to | 43 |
this research was supported | 43 |
production of infectious virus | 43 |
order to determine the | 43 |
patients with novel coronavirus | 43 |
the organization of the | 43 |
have been used in | 43 |
as a cause of | 43 |
for the assembly of | 43 |
the importance of this | 43 |
the normalized shannon entropy | 43 |
em structure of the | 43 |
phase i clinical trial | 43 |
used to calculate the | 43 |
respiratory syncytial virus and | 43 |
rna replication and transcription | 43 |
human parainfluenza virus type | 43 |
in a murine model | 43 |
expressed in escherichia coli | 43 |
is mediated by a | 43 |
to investigate the effects | 43 |
tumor necrosis factor alpha | 43 |
in the life cycle | 43 |
the mode of action | 43 |
to be used in | 43 |
viruses and their replication | 43 |
of the gene encoding | 43 |
used in combination with | 43 |
from the end of | 43 |
of the university of | 43 |
as well as on | 43 |
for the regulation of | 43 |
human respiratory disease in | 43 |
the induction of ifn | 43 |
and the evolution of | 43 |
of viral rna was | 43 |
with human respiratory disease | 43 |
most closely related to | 43 |
of g s in | 43 |
to contribute to the | 43 |
was used for statistical | 43 |
proteolytic cleavage of the | 43 |
was used to evaluate | 42 |
a significant proportion of | 42 |
by means of the | 42 |
this article is an | 42 |
involved in the pathogenesis | 42 |
with a number of | 42 |
a significant number of | 42 |
samples were obtained from | 42 |
could be explained by | 42 |
article can be found | 42 |
expression of the viral | 42 |
a man with pneumonia | 42 |
the atpase activity of | 42 |
allergy and infectious diseases | 42 |
supported by a reticulovesicular | 42 |
the concentration of the | 42 |
the induction of apoptosis | 42 |
hepatitis e virus infection | 42 |
to confirm that the | 42 |
different from that of | 42 |
for min at rt | 42 |
the viral rna and | 42 |
replication is supported by | 42 |
of the s rrna | 42 |
a region of the | 42 |
no conflicts of interest | 42 |
are presented in table | 42 |
have been made to | 42 |
was carried out at | 42 |
used as a model | 42 |
in the golgi complex | 42 |
in support of this | 42 |
as a model system | 42 |
as a model for | 42 |
c virus replication by | 42 |
was identified as the | 42 |
by a reticulovesicular network | 42 |
was performed to determine | 42 |
inhibition of viral replication | 42 |
may act as a | 42 |
as well as of | 42 |
understand the role of | 42 |
the results indicated that | 42 |
is based on a | 42 |
recent studies have shown | 42 |
a subset of the | 42 |
in the emergence of | 42 |
the control of a | 42 |
assessment of hospitalized patients | 42 |
similar to that observed | 42 |
s in the supplemental | 42 |
to the endoplasmic reticulum | 42 |
replication of mouse hepatitis | 42 |
of the viral polymerase | 42 |
is encoded by the | 42 |
reading frame of the | 42 |
may be used to | 42 |
this study aimed to | 42 |
in cd t cells | 42 |
have been isolated from | 42 |
and found that the | 42 |
induced pluripotent stem cells | 42 |
able to interact with | 42 |
coronavirus associated with human | 42 |
of the structure of | 42 |
s protein of sars | 42 |
the presence and absence | 42 |
of viral and cellular | 42 |
were used in this | 42 |
associated with human respiratory | 42 |
and has been shown | 42 |
forward and reverse primers | 42 |
fold serial dilutions of | 42 |
it is not yet | 42 |
we aimed to investigate | 42 |
least one of the | 42 |
in contrast to other | 42 |
one of the best | 42 |
respiratory disease in china | 42 |
of amino acid residues | 42 |
to be positive for | 42 |
first line of defense | 42 |
supplementary figure s a | 42 |
molecular evolutionary genetics analysis | 42 |
exclude the possibility that | 42 |
were performed as described | 42 |
can be detected by | 42 |
been identified as the | 42 |
to be used for | 42 |
clinical characteristics of cases | 42 |
the potential to be | 42 |
were used to generate | 42 |
by the severe acute | 42 |
with the viral rna | 42 |
viral gene expression and | 42 |
control of gene expression | 42 |
safety and immunogenicity of | 42 |
infectious hepatitis c virus | 42 |
was determined using the | 42 |
the treatment of severe | 41 |
both of which are | 41 |
in different types of | 41 |
with pneumonia in saudi | 41 |
based on the results | 41 |
detection and identification of | 41 |
to gain insight into | 41 |
and analysis of the | 41 |
the base of the | 41 |
amino acids in the | 41 |
has the ability to | 41 |
no significant difference between | 41 |
from a man with | 41 |
the mouse hepatitis virus | 41 |
the bottom of the | 41 |
the early secretory pathway | 41 |
at the protein level | 41 |
is not yet known | 41 |
and antiviral activity of | 41 |
brome mosaic virus rna | 41 |
was present in the | 41 |
to study the effect | 41 |
target for the development | 41 |
of the rna polymerase | 41 |
by the viral polymerase | 41 |
novel coronavirus pneumonia in | 41 |
the dynamics of the | 41 |
of the virus genome | 41 |
it is reported that | 41 |
of the human coronavirus | 41 |
is tempting to speculate | 41 |
be taken into account | 41 |
of the orf a | 41 |
significantly higher in the | 41 |
did not lead to | 41 |
a a a a | 41 |
it is reasonable to | 41 |
has been described for | 41 |
were mapped to the | 41 |
the plasma membrane and | 41 |
the introduction of a | 41 |
some of which are | 41 |
to participate in the | 41 |
a virus ns protein | 41 |
article is an open | 41 |
in the crystal structure | 41 |
the terms and conditions | 41 |
a number of viruses | 41 |
and proteome of sars | 41 |