This is a list of all the questions and their associated study carrel identifiers. One can learn a lot of the "aboutness" of a text simply by reading the questions.
| identifier | question |
|---|---|
| cord-001065-j4hvyyoi | The prevalence of viruses of honey bees in Britain Honey bee viruses: A cause for concern? |
| cord-001616-9sc2xmqr | How is the end of an Ebola outbreak decided and declared? |
| cord-000902-ew8orn0z | Whole genome molecular phylogeny of large dsDNA viruses using composition vector method Evolutionary genomics of nucleo- cytoplasmic large DNA viruses Here a virus, there a virus, everywhere the same virus? |
| cord-001985-iwfidoer | Are we missing half of the viruses in the ocean? |
| cord-002581-r7mskri0 | The New England journal of medicine Placental Inflammatory Response to Zika Virus may Affect Fetal Brain Development Zika virus intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg? |
| cord-001958-2gt3fwpy | T cell memory Comparison of lyophilized versus liquid modified vaccinia Ankara( MVA) formulations and subcutaneous versus intradermal routes of administration in healthy vaccinia- naive subjects Modified vaccinia virus Ankara as antigen delivery system: how can we best use its potential? |
| cord-003817-k3m72uxw | cellular attachment and infection Immature dengue virus: a veiled pathogen? |
| cord-003767-9xbu4hnq | Life history determines genetic structure and evolutionary potential of host- parasite interactions Are viruses alive? |
| cord-002338-ri7v2ka3 | a tool for phylogenetic analysis and post- analysis of large phylogenies Creating the CIPRES Science Gateway for inference of large phylogenetic trees How many bootstrap replicates are necessary? |
| cord-003482-f1uvohf0 | Considering the evidence that African bats are naturally susceptible to ZIKV and that little brown bats develop disease, the question emerged: could bats serve as a natural reservoir host for ZIKV in the New World? |
| cord-000050-tfcerilc | Molecular determinants within the surface proteins involved in the pathogenicity of H5N1 influenza viruses in chickens Are we ready for pandemic influenza? |
| cord-000359-y0m1utug | The Weekly Epidemiological Nipah virus outbreak from date palm juice Person- to- person transmission of Nipah virus in a Bangladeshi community Risk of nosocomial transmission of Nipah virus in a Bangladesh hospital Person- to- person transmission of Nipah virus during outbreak in Faridpur District Nipah virus- a potential agent of bioterrorism? |
| cord-003917-bswndfvk | Neglected Tropical Diseases? |
| cord-003403-ypefqm71 | A West Nile virus DNA vaccine induces neutralizing antibody in healthy adults during a phase 1 clinical trial Coimmunization with an optimized IL15 plasmid adjuvant enhances humoral immunity via stimulating B cells induced by genetically engineered DNA vaccines expressing consensus JEV and WNV E DIII Induction of potent Th1-type immune responses from a novel DNA vaccine for west nile virus New York isolate( WNV- NY1999) Development of vaccines against Zika virus Zika virus structural biology and progress in vaccine development Role of Zika Virus prM protein in viral pathogenicity and use in vaccine development Zika virus emergence in mosquitos in Southeastern Senegal Evolutionary enhancement of Zika virus infectivity in Aedes aegypti mosquitoes Assessing Seasonal risks for the introduction and mosquito- borne spread of Zika virus in Europe Zika virus vector competency of mosquitoes Aedes hensilli as a potential vector of Chikungunya and Zika viruses Outbreak of Zika virus infection, Chiapas State, Mexico, 2015, and first confirmed transmission by aedes aegypti mosquitoes in the Americas Autophagy and viral diseases transmitted by Aedes aegypti and Aedes albopictus Zika virus: Following the path of dengue and chikungunya? |
| cord-000265-llilwq1u | Clinical characteristics of 26 human cases of highly pathogenic avian influenza A( H5N1) virus infection in China Clinical features and rapid viral diagnosis of human disease associated with avian influenza A H5N1 virus Influenza A/ H5N1 virus infection in humans in Cambodia Fatal avian influenza A( H5N1) in a child presenting with diarrhea followed by coma Pathology of fatal human infection associated with avian influenza A H5N1 virus Influenza virus entry and infection require host cell N- linked glycoprotein Fatal outcome of human influenza A( H5N1) is associated with high viral load and hypercytokinemia Re- emergence of fatal human influenza A subtype H5N1 disease Induction of proinflammatory cytokines in human macrophages by influenza A( H5N1) viruses: a mechanism for the unusual severity of human disease? |
| cord-000933-nn9gj0z1 | Dual wavelength imaging allows analysis of membrane fusion of influenza virus inside cells Pharmacological inhibition of endocytic pathways: is it specific enough to be useful? |
| cord-001834-6xf4o3oy | : What can we look forward to? |
| cord-002933-zmx4k46v | Why do dengue viruses universally cleave human but not monkey STING? |
| cord-002410-2zi5iv2t | The family of IL-10-related cytokines and their receptors: related, but to what extent? |
| cord-000539-uh3q65we | A Strain- Dependent Pathogenesis in Fatal H1N1 and H5N1 Subtype Infections of Mice Animal models for the study of influenza pathogenesis and therapy Transmission and pathogenesis of swine- origin 2009 A( H1N1) influenza viruses in ferrets and mice Variations in the Hemagglutinin of the 2009 H1N1 Pandemic Virus: Potential for Strains with Altered Virulence Phenotype? |
| cord-000539-uh3q65we | Pandemic Influenza A( H1N1) Virus Affects Receptor Binding Observed association between the HA1 mutation D222 G in the 2009 pandemic influenza A(H1N1) virus and severe clinical outcome Markers for predicting the development of acute respiratory distress syndrome Radiological prognostic factors in patients with pandemic H1N1( pH1N1) infection requiring hospital admission Serial Histopathological Examination of the Lungs of Mice Infected with Influenza A Virus PR8 Strain Pulmonary surfactant in health and human lung diseases: state of the art Serial changes in surfactant- associated proteins in lung and serum before and after onset of ARDS Genomic analysis of increased host immune and cell death responses induced by 1918 influenza virus Induction of proinflammatory cytokines in human macrophages by influenza A( H5N1) viruses: a mechanism for the unusual severity of human disease? |
| cord-003122-a3f4l6iu | How single mutations affect viral escape from broad and narrow antibodies to H1 influenza hemagglutinin Immunogen design for HIV-1 and influenza Is it possible to develop a"universal"influenza virus vaccine? |
| cord-003122-a3f4l6iu | neuraminidases Neuraminidase receptor binding variants of human influenza A(H3N2) viruses resulting from substitution of aspartic acid 151 in the catalytic site: a role in virus attachment? |
| cord-000937-8vk89i4h | A novel DNA virus( TTV) associated with elevated transaminase levels in posttransfusion hepatitis of unknown etiology TT- virus infection in North American blood donors, patients with fulminant hepatic failure, and cryptogenic cirrhosis TT viruses: oncogenic or tumorsuppressive properties? |
| cord-000937-8vk89i4h | clusters of orthologous genes and reconstruction of viral genome evolution GB virus C replicates in primary T and B lymphocytes GB virus type C/ hepatitis G virus: a non- pathogenic flavivirus associated with prolonged survival in HIV- infected individuals GB virus C: the good boy virus? |
| cord-002327-tocqabgu | A T cell- inducing influenza vaccine for the elderly: safety and immunogenicity of MVA- NPCM1 in adults aged over 50 years Coadministration of seasonal influenza vaccine and MVA- NPCM1 simultaneously achieves potent humoral and cell- mediated responses Broad protection against avian influenza virus by using a modified vaccinia Ankara virus expressing a mosaic hemagglutinin gene Universal influenza vaccines, science fiction or soon reality? |
| cord-002327-tocqabgu | A pandemic warning? |
| cord-003926-ycdaw2vh | Isolations and serological specificity Zika virus: Following the path of dengue and chikungunya? |
| cord-003926-ycdaw2vh | Tip of the iceberg? |
| cord-003044-9uqa39j9 | Can we identify host genes in functional classes whose expression depends on viral fitness? |
| cord-003044-9uqa39j9 | To what extent does viral fitness result from specific molecular interactions with host factors and regulatory networks during infection? |
| cord-004830-vmka378d | Contaminating antibodies against cellular components were removed from the antisera by absorption with solid immunoadsorbents containing allantoic fluid as host antigens(]? |
| cord-006997-sghhdjyi | DOI: 10.1016/0035- 9203(78)90308- 5 sha: 141642b67f075b89d40bea1fd758c1564c0a9334 doc_id: 6997 cord_uid: sghhdjyi nan Viruses and diarrhoea in West Africa and London: a collaborative study M Diarrhoea, particularly of children, is a major unsolved world- wide nroblem( ELLIOTT. 1976) and there is dispute abou? |
| cord-003492-rodqdtfj | Do they protect against disease or enhance it? |
| cord-003492-rodqdtfj | inflammasome- mediated IL-1β induction Porcine reproductive and respiratory syndrome virus( PRRSV) inhibits RNAmediated gene silencing by targeting ago-2 Novel insights into host responses and reproductive pathophysiology of porcine reproductive and respiratory syndrome caused by PRRSV-2 Comparison of host genetic factors influencing pig response to infection with two North American isolates of porcine reproductive and respiratory syndrome virus Variation among sows in response to porcine reproductive and respiratory syndrome 1 Genetic resistance-an alternative for controlling PRRS? |
| cord-002407-25cawzi0 | ( H2N2) Cold- adapted live- attenuated influenza vaccines developed in russia: Can they contribute to meeting the needs for influenza control in other countries? |
| cord-002407-25cawzi0 | Development of new generation influenza vaccines: Recipes for success? |
| cord-001397-nrq4ncdf | Why is tick- borne encephalitis increasing? |
| cord-001397-nrq4ncdf | an update Internally deleted WNV genomes isolated from exotic birds in New Mexico: function in cells, mosquitoes, and mice Modeling antibody- enhanced Dengue virus infection and disease in mice: protection or pathogenesis? |
| cord-007733-zh8e76w7 | How much experience do we have with pandemic influenza virus vaccines? |
| cord-001974-wjf3c7a7 | How Does Multiple Testing Correction Work? |
| cord-001974-wjf3c7a7 | What's in Your next- Generation Sequence Data? |
| cord-003598-m2fsrwvw | Innate immune responses to influenza A H5N1: friend or foe? |
| cord-003598-m2fsrwvw | Old drugs losing effectiveness against flu; could statins fill gap? |
| cord-000708-iuo2cw23 | These results indicate that, first of all, it is common for herpesviruses to incorporate cellular proteins into their viral particles and, secondly, that www.frontiersin.org? |
| cord-000708-iuo2cw23 | has multiple functions in gene regulation and cell cycle control and is a prime target for viral manipulation Viruses and the human DEAD- box helicase DDX3: inhibition or exploitation? |
| cord-005885-r3qtoqu1 | Laut einschlägiger Empfehlungen des Robert Koch- Instituts( https://www.rki.de/DE/Content/ Infekt/ Krankenhaushygiene/ Kommission/ Downloads/ UebersInfektionserkrMassn_2016.pdf?__ blob= publicationFile; letzter Abruf 30.08.2019) sollen in Einrichtungen des Gesundheitswesens an Masern Erkrankte nach Auftreten des Exanthems für 4 Tage-also bis zum 5. |
| cord-007575-5ekgabx5 | Diffuse pneumonia and acute respiratory failure due to infectious mononucleosis Clinical, virologic, and serologic evidence of Epstein- Barr virus infection in association with childhood pneumonia Pneumonia associated with rising cytomegalovirus antibody titres in a healthy adult Does cytomegalovirus playa role in communityacquired pneumonia? |
| cord-003792-v48xeqdz | How important is vertical transmission in mosquitoes for the persistence of dengue? |
| cord-003792-v48xeqdz | How important is vertical transmission of dengue viruses by mosquitoes( Diptera: Culicidae)? |
| cord-008149-kdlcaium | How is Europe positioned for a re- emergence of Schmallenberg virus? |
| cord-007094-ur9sz21s | Symposium Studies of the mechanism of spontaneous germline ecotropic provirus acquisition in mice Mouse antibody production test: Can we do without it? |
| cord-007149-m4xsx9ev | The generation of human monocyte/ macrophage cell lines DNA- mediated gene transfer in friend leukemia cells by cotransfection of simian virus 40 DNA with herpes simplex virus thymidine kinase DNA Macrophage nomenclature; where are we going Retroviral transforming genes in normal cells? |
| cord-007792-596jxrm5 | The evolution of human infl uenza viruses Developing new antiviral agents for infl uenza treatment: what does the future hold? |
| cord-004501-guiy89x8 | Up to now we have concluded that current antiviral therapy has not yet achieved the ideal shape and efficiency and also that the complex biological barriers are major obstacles, but can we critically say that nanotechnology could be the identified solution? |
| cord-004501-guiy89x8 | Viral pneumonia La Revue de Médecine Interne Viral myocarditis Viral infections in type 1 diabetes mellitus- Why the β cells? |
| cord-007784-fq2urilg | Why do swine make such good mixing vessels? |
| cord-004827-bnf3mvaf | ( Samuel Roberts Noble Foundation, Ardmore OK) asked"What determines the quasispecies population size? |
| cord-004827-bnf3mvaf | The question arose: how can one recognize if a calculated fold is real? |
| cord-003861-qeao4ghg | What does virus evolution tell us about virus origins? |
| cord-003861-qeao4ghg | Why are RNA virus mutation rates so damn high? |
| cord-003861-qeao4ghg | Why do RNA viruses recombine? |
| cord-001831-3aonqyub | Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: Clinical features and pathogenesis Progressive multifocal leukoencephalopathy and other forms of JC virus disease JC virus: An oncogenic virus in animals and humans? |
| cord-001831-3aonqyub | The minimalist architectures of viroporins and their therapeutic implications Mechanisms of membrane permeabilization by picornavirus 2B viroporin Protein- Protein Interactions of Viroporins in Coronaviruses and Paramyxoviruses: New Targets for Antivirals? |
| cord-001831-3aonqyub | key: cord-001831- 3aonqyub authors: Royle, Jamie; Dobson, Samuel John; Müller, Marietta; Macdonald, Andrew title: Emerging Roles of Viroporins Encoded by DNA Viruses: Novel Targets for Antivirals? |
| cord-005246-cskb0njm | conqueror, conquest? |
| cord-005246-cskb0njm | the requirements for high level expression of proteins, including glycoproteins Protection of mice against lethal Japanese encephalitis with a recombinant baculovirus vaccine Use of recombinant fusion proteins and monoclonal antibodies to define linear and discontinuous antigenic sites on the dengue virus envelope glycoprotein Carboxy- terminally truncated dengue virus envelope glycoproteins expressed on the cell surface and secreted extracellularly exhibit increased immunogenicity in mice Biological characterization of plaque- size variants of yellow fever virus in mosquitoes and mice Yellow fever: Victor, Victoria? |
| cord-003130-p2h8p5bm | Red arrow= secretory pathway, blue arrow="? |
| cord-003130-p2h8p5bm | To what extent has climate change contributed to the recent epidemiology of tick- borne diseases? |
| cord-003130-p2h8p5bm | Why is tick- borne encephalitis increasing? |
| cord-007843-yqdqm4rh | Unique challenges of hepatitis C in infants, children, and adolescents Hepatitis C management simplification from test to cure: a framework for primary care providers Live attenuated influenza vaccine: is past performance a guarantee of future results? |
| cord-006892-n2ncamqh | Better influenza vaccines for older people: what will it take? |
| cord-006892-n2ncamqh | different virus- like particles be used for primeboost vaccination? |
| cord-010016-fs8pjy1z | authors: WEBB, H. E.; FAZAKERLEY, J. K. title: CAN VIRAL ENVELOPE GLYCOLIPIDS PRODUCE AUTO‐IMMUNITY, WITH REFERENCE TO THE CNS AND MULTIPLE SCLEROSIS? |
| cord-007764-7750z41g | Addressing parents'concerns: do vaccines contain harmful preservatives, adjuvants, additives, or residuals? |
| cord-007764-7750z41g | Is it to be distributed as a liquid or as a lyophilized powder, to be reconstituted with diluent prior to use? |
| cord-005081-kxrzv16n | The natural question has been raised for years: Is it possible to develop some universal anti influenza A vaccine based on the agent's conservative proteins? |
| cord-005081-kxrzv16n | What are basic prospects opening before the vac cines constructed using state of the art genetic engi neering techniques? |
| cord-000012-p56v8wi1 | Science Are there bugs in our genome? |
| cord-000012-p56v8wi1 | The genome of Melanoplus sanguinipes entomopoxvirus Cloning and expression of a gene encoding a Campoletis sonorensis polydnavirus structural protein A gene encoding a polydnavirus structural polypeptide is not encapsidated What does structure tell us about virus evolution? |
| cord-000012-p56v8wi1 | redox considerations for HIV and SARS- coronavirus Genetic recombination of the DNA plant virus PBCV-1 in a chlorella alga Common origin of four diverse families of large eukaryotic DNA viruses Evolutionary genomics of nucleo- cytoplasmic large DNA viruses Effects of the nonoccluded virus of Spodoptera frugiperda( Lepidoptera: Noctuidae) on the development of a parasitoid Parasitoid- mediated transmission of an iridescent virus Non- poly- DNA viruses, their parasitic wasp, and hosts The few virus- like genes of Cotesia congragata Self- synthesizing DNA transposons in eukaryotes Marvericks, a novel class of giant transposable elements widespread in eukaryotes and related to DNA viruses Evolution of viruses by acquisition of cellular RNA or DNA nucleotide sequences and genes: an introduction Microbialgenes in the human genome: lateral transfer or gene loss? |
| cord-006129-5rog0s98 | Are viral- encoded microRNAs mediating latent HIV-1 infection? |
| cord-006129-5rog0s98 | Current perspectives in microRNAs( miRNA) Host- virus interaction: a new role for microRNAs Silencing viral microRNA as a novel antiviral therapy? |
| cord-007731-wu7i548j | A H5N1 replication sites in humans Avian infl uenza and sialic acid receptors: more than meets the eye? |
| cord-000804-0hlj6r10 | Is Marburg virus enzootic in Gabon? |
| cord-000804-0hlj6r10 | The morbid anatomy of Marburg virus disease Marburg and Ebola hemorrhagic fevers: does the primary course of infection depend on the accessibility of organ- specific macrophages? |
| cord-000804-0hlj6r10 | Viral hemorrhagic fever- a vascular disease? |
| cord-006790-lye0qjw8 | On the second day after disease onset lymphocyte( 0.5 9 10 9/l), CD4? |
| cord-006790-lye0qjw8 | T cell( 25 cell/ ll) and CD8? |
| cord-010235-hu6o1ggc | The Federal Judicial Center's Reference Manual on Scientific Evidence, intended as a guide for judges, lawyers, and experts, asks a fundamental question: Is the expert qualified? |
| cord-011917-6u0t4hy8 | The establishment of surrogates and correlates of protection: Useful tools for the licensure of effective influenza vaccines? |
| cord-002757-upwe0cpj | : can we retain the clinical use of mold- active antifungal azoles? |
| cord-002757-upwe0cpj | Contribution of Working Groups I, II and III to the Fifth Assessment Report of the Intergovernmental Panel on Climate Change Impact of climate change in the epidemiology of vector- borne diseases in domestic carnivores Impact of climate change on human infectious diseases: empirical evidence and human adaptation Climate change and health: global to local influences on disease risk Climate change and mosquito- borne disease Climate of origin affects tick( Ixodes ricinus) host- seeking behavior in response to temperature: implications for resilience to climate change? |
| cord-002757-upwe0cpj | The burden of co- infection with human immunodeficiency virus type 1 and malaria in pregnant women in sub- saharan Africa Is there an interaction between human immunodeficiency virus and Plasmodium falciparum? |
| cord-012582-k1mjik27 | In this context, a relevant question arises: What can chemistry do in the search for new strategies and approaches to solve this emergent problem? |
| cord-002728-6oyw5sqv | Environ Microbiol Rep Exploiting gut bacteriophages for human health Characterization of a bacteriophage- derived murein peptidase for elimination of antibiotic- resistant Staphylococcus aureus Ecology of prokaryotic viruses Bacteriophage receptors, mechanisms of phage adsorption and penetration into host cell Comparative( meta)genomic analysis and ecological profiling of human gut- specific bacteriophage φB124- 14 CRISPR targeting reveals a reservoir of common phages associated with the human gut microbiome Dysbiosis in inflammatory bowel disease: a role for bacteriophages? |
| cord-002728-6oyw5sqv | Here a virus, there a virus, everywhere the same virus? |
| cord-002728-6oyw5sqv | What are exosomes, exactly? |
| cord-010343-tqqt0hj7 | The potential spread of infection caused by aerosol contamination of surfaces after flushing a domestic toilet Effects of cleaning and disinfection in reducing the spread of Norovirus contamination via environmental surfaces Contamination of the hospital environment with gastroenteric viruses: comparison of two pediatric wards over a winter season How long do nosocomial pathogens persist on inanimate surfaces? |
| cord-013176-6ckuya1w | : Is There Sufficient Evidence to Define a Health- Promoting Polyphenol- Rich Dietary Pattern? |
| cord-002337-8v907g24 | For example, should we interpret high sustained levels of human spillover as evidence of increased risk because of the number of human infections, or as evidence of decreasing risk because of the number of times the strain has failed to achieve sustained transmission? |
| cord-002337-8v907g24 | Granularity of pandemic risk prediction-for what taxonomic level does it make sense? |
| cord-002337-8v907g24 | More deliberate approaches to the design of surveillance systems would also depend on answering the question addressed in Box 2: how different must a virus be from previously characterized viruses to merit separate evaluation of its pandemic risk? |
| cord-002337-8v907g24 | the next generation How sticky should a virus be? |
| cord-005281-wy0zk9p8 | CRISPR/ Cas systems Cpf1 is a single RNA- guided endonuclease of a class 2 CRISPR- Cas system How many antiviral small interfering RNAs may be encoded by the mammalian genomes? |
| cord-005281-wy0zk9p8 | Can viruses make us human? |
| cord-005281-wy0zk9p8 | The next genetics revolution? |
| cord-013526-6fip93l2 | Extracellular Vesicles Mediate Receptor- Independent Transmission of Novel Tick- Borne Bunyavirus Extracellular vesicles: a new communication paradigm? |
| cord-009561-pg4jmvw4 | Virus isolated from the brain of a patient with multiple sclerosis Transmission experiments with multiple sclerosis Decreased percentage of polyrnorphonuclear neutrophils in mouse peripheral blood after inoculation with material from multiple sclerosis patients Fusion of culcured multiple sclerosis brain cells with indicator cellspresence of nucleocapsids and virions and isolation of parainfluenza- type virus Viruses in multiple sclerosis? |
| cord-009561-pg4jmvw4 | What have we learned from other demyelinating diseases? |
| cord-011106-h20vbmbo | Biochemical and Biophysical Research Communications Intranasal inactivated influenza vaccines: A reasonable approach to improve the efficacy of influenza vaccine? |
| cord-007170-svsfu7fj | A possible etiological factor in human affective disorders? |
| cord-007170-svsfu7fj | Borna virus cDNA encoding a protein recognized by antibodies in humans with behavioral diseases Analysis of Borna disease virus- specific RNAs in infected cells and tissues Replication of Borna disease virus in cell cultures Influence of interferon on persistent infection caused by Borna disease virus in vitro Borna disease, a possible hazard for man? |
| cord-012418-6ralcn8p | Related Compounds Inhibition of virus multiplication by foreign nucleic acid Approaching the asymptote? |
| cord-015764-ly68q5z0 | une nouvelle stratégie thérapeutique dans les viroses graves? |
| cord-016538-4og05fuo | Are there aspects of virus- host interactions that are unique to woody and perennial plants compared to annual herbaceous plants? |
| cord-016754-6fv8mjld | Demonstration of person- to- person transmission by temporal clustering of cases Natural history of human calicivirus infection: a prospective cohort study Rotavirus and central nervous system symptoms: cause or contaminant? |
| cord-016995-5izyl234 | Thai dogs carry bird- flu virus, but will they spread it? |
| cord-008686-9ybxuy00 | ( H 7 N 9) viruses in the fifth wave-Increasing threat to both birds and humans? |
| cord-008686-9ybxuy00 | Given the results that are currently available from this study, one of the key questions is: from where did the NL63 and OC43 coronaviruses arise? |
| cord-008686-9ybxuy00 | Influenza Other Respir Viruses Is higher viral load in the upper respiratory tract associated with severe pneumonia? |
| cord-013073-siy7dvlo | The question is, where does the virus persist during the off- season time of more than 6 months? |
| cord-013073-siy7dvlo | coincident or causal? |
| cord-014908-jys1y0k9 | derivative bearing[ Os(5,6-dimethyl-1,10-phenanthroline)2Cl]2? |
| cord-011438-imbpgsub | NO apoptosis or turning it ON? |
| cord-011438-imbpgsub | Seasonal and Pandemic Human Influenza Viruses Attach Better to Human Upper Respiratory Tract Epithelium than Avian Influenza Viruses Human and Avian Influenza Viruses Target Different Cells in the Lower Respiratory Tract of Humans and Other Mammals Avian influenza and sialic acid receptors: More than meets the eye? |
| cord-007362-pjpkz6wv | Peracute death with an overall lack of gross lesions or with hemorrhages of the Peyer's patches as the only grossly apparent lesion may be a frequent event in this syndrome? |
| cord-007362-pjpkz6wv | Serological titers to bovine herpesvirus 1, bovine viral diarrhea virus, parainfluenza 3 virus, bovine respiratory syncytial virus and Pasteurella haemolytica in feedlot calves with respiratory disease Promethean viruses? |
| cord-007362-pjpkz6wv | it may be questioned whether the BVDV infection is the cause of the atrophy or whether other events( parturition stress, neonatal infection, insufficient nutrition) around the time of delivery are the( additional?) cause(s) of an acute involution, which could have been reversible and inconsequential given time and appropriate care. |
| cord-004211-58x3nnsc | The Epidemiology of Rift Valley Fever in Mayotte: insights and perspectives from 11 years of data Rift Valley fever, Mayotte Rift valley fever in humans and animals in Mayotte, an endemic situation? |
| cord-004211-58x3nnsc | The first imported case of Rift Valley fever in China reveals a genetic reassortment of different viral lineages Emerging Rift Valley fever in China: what should be known? |
| cord-004211-58x3nnsc | a clinical study of severe illness in humans Sequential Rift Valley fever outbreaks in eastern Africa caused by multiple lineages of the virus Has Rift Valley fever virus evolved with increasing severity in human populations in East Africa? |
| cord-004211-58x3nnsc | over Ready to submit your research? |
| cord-006089-08g206kf | Cumulative number of confirmed human cases of avian influenza A/(H5N1) reported to WHO Molecular basis for the generation in pigs of influenza A viruses with pandemic potential Human and avian influenza viruses target different cell types in cultures of human airway epithelium Avian flu: influenza virus receptors in the human airway Influenza virus strains selectively recognize sialyloligosaccharides on human respiratory epithelium; the role of the host cell in selection of hemagglutinin receptor specificity H5N1 virus attachment to lower respiratory tract Differences between influenza virus receptors on target cells of duck and chicken Quail carry sialic acid receptors compatible with binding of avian and human influenza viruses Avian H5N1 influenza in cats Avian influenza H5N1 in tigers and leopards Bird flu spreads among Java's pigs Feline friend or potential foe? |
| cord-006089-08g206kf | Molecular virology: was the 1918 pandemic caused by a bird flu Molecular virology: Was the 1918 pandemic caused by a bird flu? |
| cord-006089-08g206kf | The nucleoprotein as a possible major factor in determining host specificity of influenza H3N2 viruses Updating the accounts: global mortality of the 1918- 1920'Spanish'influenza pandemic Molecular virology: was the 1918 flu avian in origin? |
| cord-006640-25ykas09 | Clinical management of Ebola virus disease in the United States and Europe Experimental therapies for Ebola virus disease: what have we learned? |
| cord-006640-25ykas09 | How will physicians confront the next influenza pandemic? |
| cord-006640-25ykas09 | In defense of case reports and case series When are randomised trials unnecessary? |
| cord-003302-vxk7uqlc | In essence, they have asked'why did young adults die?' |
| cord-003302-vxk7uqlc | The pandemic influenza preparedness framework: a visible procurement option for developing states? |
| cord-003302-vxk7uqlc | They could also have asked'why did children live?' |
| cord-003302-vxk7uqlc | the predominant cause of death in the 1918- 1919 influenza pandemic? |
| cord-017959-g0nf1iwm | Recent multistate outbreaks of human salmonella infections acquired from turtles: a continuing public health challenge Host range and emerging and reemerging pathogens Overviews of pathogen emergence: which pathogens emerge, when and why? |
| cord-001542-f089bs8r | -beta an alternative treatment for chronic hepatitis C? |
| cord-001542-f089bs8r | Do therapeutic antibodies hold the key to an effective treatment for Ebola hemorrhagic fever? |
| cord-001542-f089bs8r | Early epidemic dynamics of the West African 2014 Ebola outbreak: estimates derived with a simple two- parameter model Filoviruses": a real pandemic threat? |
| cord-001542-f089bs8r | Is β- interferon a promising therapeutic option for the management of hepatitis C? |
| cord-001542-f089bs8r | VP40 be a drug target? |
| cord-009577-29u7pdpk | By taking genomic segments from neuroinvasive and noninvasive strains, one can ask the question: which genome segment is responsible for the ability to penetrate the CNS? |
| cord-009577-29u7pdpk | Enhancer elements Continuous cultures of fused cells secreting antibodies of predetermined specificity Moloney sarcoma virus Enhancement of the infectivity of influenza A and B viruses by proteolytic cleavage of the hemagglutinin polypeptide Is the acetylcholine receptor a rabies virus receptor? |
| cord-009577-29u7pdpk | Tyler and collaborators exploited this fact to test reassortants of type 1 and type 3 viruses and again ask the question: which gene segmeiit accounts for the different patterns of spread in these two strains? |
| cord-007796-zggk0x2q | : Is there a causal relationship? |
| cord-007796-zggk0x2q | NF- kappa B Do rhinoviruses cause pneumonia in children? |
| cord-007796-zggk0x2q | Pathophysiological mechanisms for the respiratory syncytial virus- reactive airway disease link Respiratory syncytial virus and subsequent asthma: One step closer to unravelling the Gordian knot? |
| cord-007796-zggk0x2q | Predictive value for subsequent development of persistent wheezing Are we ready for universal influenza vaccination in paediatrics? |
| cord-017758-zfudssm9 | Emerging hemorrhagic fever in China caused by a novel bunyavirus SFTSV Characterization of severe fever with thrombocytopenia syndrome in rural regions of Zhejiang A study of seroprevalence and rates of asymptomatic viremia of severe fever with thrombocytopenia syndrome virus among Chinese blood donors Systemic review of severe fever with thrombocytopenia syndrome: virology, epidemiology, and clinical characteristics Seroprevalence of antibodies against SFTS virus infection in farmers and animals Acute thrombocytopenia, leucopenia, and multiorgan dysfunction: the first case of SFTS Bunyavirus outside of China? |
| cord-018319-tylkbh4h | Can respiratory syncytial virus and influenza A be distinguished clinically in institutionalized older persons? |
| cord-018463-a6qu0cuv | Are there sure measures for preventing misuse by modern biomedical techniques leading to results harmful for humans? |
| cord-017752-ofzm3x3a | A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma Is cancer dangerous to the immune system? |
| cord-018302-lmly43rd | hematopoietic cell transplant recipients Comparison of nasopharyngeal fl ocked swabs and nasopharyngeal wash collection methods for respiratory virus detection in hospitalized children using real- time polymerase chain reaction Implementation of fi lmarray respiratory viral panel in a core laboratory improves testing turnaround time and patient care Comparison of three commercial RT- PCR systems for the detection of respiratory viruses Evaluation of quantitative and type- specifi c real- time RT- PCR assays for detection of respiratory syncytial virus in respiratory specimens from children Application of TaqMan low- density arrays for simultaneous detection of multiple respiratory pathogens Detection and quantifi cation of human metapneumovirus in pediatric specimens by real- time RT- PCR Respiratory syncytial virus lower respiratory disease in hematopoietic cell transplant recipients: viral RNA detection in blood, antiviral treatment, and clinical outcomes Evaluation of R- Mix FreshCells in shell vials for detection of respiratory viruses Rapid detection of respiratory viruses by shell vial culture and direct staining by using pooled and individual monoclonal antibodies Clinically useful method for the isolation of respiratory syncytial virus Detection of human metapneumovirus antigens in nasopharyngeal secretions by an immunofl uorescent- antibody test Nosocomial transmission of respiratory syncytial virus in immunocompromised adults Antigenic and nucleic acid analysis of nosocomial isolates of respiratory syncytial virus Molecular characterization of strains of respiratory syncytial virus identifi ed in a hematopoietic stem cell transplant outpatient unit over 2 years: community or nosocomial infection? |
| cord-013412-gj443yei | Is antimicrobial resistance a slowly emerging disaster? |
| cord-013412-gj443yei | The G- Quadruplex/ Helicase World as a Potential Antiviral Approach against COVID-19 Targets and tools in antiviral therapy G- quadruplexes in pathogens: A common route to virulence control? |
| cord-013412-gj443yei | Type III Photochemical Mechanism? |
| cord-016990-ot1wi3xi | : a review of ten years'experience Pulmonary complications of solid organ and hematopoietic stem cell transplantation Lungs are a major organ site of cytomegalovirus latency and recurrence Spectrum of pulmonary diseases associated with the acquired immune deficiency syndrome Cytomegalovirus- induced alveolar hemorrhage in patients with AIDS: a new clinical entity? |
| cord-016990-ot1wi3xi | How do viral infections predispose patients to bacterial infections? |
| cord-016652-x8t3lf1x | I rex- encoded protein is essential for cytoplasmic accumulation of unspliced viral mRNA Identification of nucleophosmin/ B23, an acidic nucleolar protein, as a stimulatory factor for in vitro replication of adenovirus DNA complexed with viral basic core proteins Induction of apoptosis by viruses: what role does the nucleolus play? |
| cord-016652-x8t3lf1x | the nucleolus-a gateway to viral infection? |
| cord-007445-2folsh35 | A number of long- term prospective studies of children admitted to a hospital with documented RSV- induced bronchiolitis have shown that about 75% experience wheezing in the first 2 years after the initial illness, more than 50% still wheeze 3 years later, and approximately 40% continue to wheeze after 5 years?,, 49, 733 91, 117, Additional insight into these areas recently was provided by the results of an ll- year prospective study involving 880 children who were enrolled at birth, followed for the development of lower respiratory tract illnesses( LRIs) in the first 3 years of life, and then evaluated for the presence or absence of physician- diagnosed asthma or a history of current wheezing at ages 6 and 11 years.14 |
| cord-007445-2folsh35 | Interactions between these two factors appear to be bidirectional and dynamic, in that the atopic state can influence the lower airway response to viral infections? |
| cord-007445-2folsh35 | These experiments are of interest based on the adverse clinical response noted in many infants who received a formalin- inactivated RSV vaccine and subsequently became infected with RSV? |
| cord-007445-2folsh35 | in which 25% to 50% of human peripheral blood T cells express the early activation marker CD69 after 24 hours in culture with RV.36 RANTES, induced by respiratory viruses, at high concentrations can also induce antigen- independent T- cell activation? |
| cord-003961-gs75ebo4 | And does eHEV have a different uncoating mechanism from naked HEV? |
| cord-003961-gs75ebo4 | Does eHEV entry involve membrane fusion? |
| cord-003961-gs75ebo4 | Infection beyond the liver? |
| cord-003961-gs75ebo4 | The structure of the poliovirus 135S cell entry intermediate at 10-angstrom resolution reveals the location of an externalized polypeptide that binds to membranes TIM- family proteins promote infection of multiple enveloped viruses through virion- associated phosphatidylserine TIM1( HAVCR1): an Essential"Receptor"or an"Accessory Attachment Factor"for Hepatitis A Virus? |
| cord-003961-gs75ebo4 | and how is its cell tropism determined? |
| cord-017249-la5sum39 | Infl uenza- associated hospitalizations in the United States Estimating the burden of 2009 pandemic infl uenza A( H1N1) in the United States Critically ill patients with 2009 infl uenza A(H1N1) infection in Canada Prevention and control of infl uenza with vaccines The role of host genetics in susceptibility to infl uenza: a systematic review Mortality and morbidity burden associated with A/ H1N1pdm infl uenza virus: who is likely to be infected, experience clinical symptoms, or die from the H1N1pdm 2009 pandemic virus? |
| cord-017249-la5sum39 | The impact of infl uenza epidemics on hospitalizations Overview of infl uenza surveillance in the United States Syndromic surveillance for local outbreaks of lower- respiratory infections: would it work? |
| cord-018477-hgvqd1ej | How Do Viruses Spread in the Organism? |
| cord-009702-02bo7pnl | How efficient are the vaccines? |
| cord-009702-02bo7pnl | On another aspect of epidemic control what proportion of a susceptible population was it necessary to vaccinate to halt the spread of infection? |
| cord-009702-02bo7pnl | Was the use of insecticidal sprays of any value? |
| cord-016309-6mw8okmt | Combination chemotherapy: interaction of 5-methoxymethyldeoxyuridine with adenine arabinoside, 5-ethyldeoxyuridine, 5-iododeoxyuridine, and phosphonoacetic acid against herpes simplex virus types 1 and 2 Single- chain fragment variable antibody against the capsid protein of bovine immunodeficiency virus and its use in ELISA Cham Bracklein T et al( 2006) Activity of feline interferon- omega after ocular or oral administration in cats as indicated by Mx protein expression in conjunctival and white blood cells High- content screening in infectious diseases History and progress of antiviral drugs: from acyclovir to directacting antiviral agents( DAAs) for Hepatitis C Natural products to drugs: natural product- derived compounds in clinical trials Efficacy, toxicology and clinical applications of ribavirin against virulent RNA viral infections Synthesis and antiviral evaluation of trisubstituted indole N- nucleosides as analogues of 2, 5, 6-trichloro-1-(β- D- ribofuranosyl) benzimidazole( TCRB) Expression and characterization of a recombinant porcinized antibody against the E2 protein of classical swine fever virus Drug repurposing: new treatments for zika virus infection? |
| cord-016309-6mw8okmt | Synthesis and antiviral activity Is AZT/3TC therapy effective against FIV infection or immunopathogenesis? |
| cord-015871-1tuf4zxi | When are observational studies as credible as randomised trials? |
| cord-015871-1tuf4zxi | Wherefore interferon? |
| cord-015871-1tuf4zxi | Yet, despite this effect, why does CCHFV still run its devastating course? |
| cord-019051-gtruu1op | Antibody response and protective effect against acute respiratory disease due to adenovirus type 7 A newly discovered human pneumovirus isolated from young children with respiratory tract disease Human metapneumovirus International Committee on Taxonomy of Viruses Characterization of human metapneumoviruses isolated from patients in North America Global genetic diversity of human metapneumovirus fusion gene Use of the P gene to genotype human metapneumovirus identifies 4 viral subtypes Analysis of the genomic sequence of a human metapneumovirus Respiratory syncytial virus and parainfluenzavirus Individual contributions of the human metapneumovirus F, G, and SH surface glycoproteins to the induction of neutralizing antibodies and protective immunity Human metapneumovirus and lower respiratory tract disease in otherwise healthy infants and children Detection of severe human metapneumovirus infection by real- time polymerase chain reaction and histopathological assessment Human metapneumovirus infections in hospitalized children Brief communication: Fatal human metapneumovirus infection in stem- cell transplant recipients Human metapneumovirus Perspective on the host response to human metapneumovirus infection: What can we learn from respiratory syncytial virus infections? |
| cord-021805-2j07zw6q | Human coronaviruses: what do they cause? |
| cord-018166-savdgy0u | The epidemiology of paralytic poliomyelitis in Hawaii USEPA Manual Methods for Virology Effect of activated sludge wastewater treatment plant on ambient air densities of aerosols containing bacteria and viruses Concentration of viruses from large volumes of tap water using pleated membrane filters Comparison between adsortion of poliovirus and rotavirus by aluminum hydroxide and activated sludge flocs Viruses and the Gut Epidemiological research on the relationship between microbial quality of coastal seawater and rotavirus induced gastroenteritis among bathers on the Mediterranean Israeli beaches Survival of bacterial indicator organisms and enteric viruses in the Mediterranean coastal waters of Tel- Aviv Viral antibodies in agricultural populations exposed to aerosols from wastewater irrigation during a viral disease outbreak Effect of the fat content of ground beef on the heat inactivation of poliovirus Viral pollution of seawater at Barcelona Adenovirus type 3 epidemic associated with intermittent chlorination of a swimming pool Survival of human enteroviruses in the Hawaiian Ocean environment: evidence for virus inactivating microorganisms Adsorption- elution with negatively and positively- charged glass powder for the concentration of hepatitis A virus from water Genotyping of rotaviruses isolated from sewage Presence of viral genomes in mineral water: a sufficient condition to assume infectious risk? |
| cord-018166-savdgy0u | marin à partir d'échantillons de volumes différents An outbreak of calicivirus associated gastroenteritis in an elderly persons home: a possible zoonosis? |
| cord-021116-rh0e4n2w | When dealing with sickness and contagion( and how else to define suicidal mania that spreads like wildfire in fundamentalist cultures and in rigid communities of machine- like automatons?) |
| cord-022084-hap7flng | The Argentinian experience Regional perspectives on influenza surveillance in South America Clinical and epidemiologic importance of influenza A viruses resistant to amantadine and rimantadine Pandemic influenza: Is an antiviral response realistic? |
| cord-018437-yjvwa1ot | The size and conformation of Kaposi's sarcoma- associated herpesvirus( human herpesvirus 8) DNA in infected cells and virions Characterization of a novel coronavirus associated with severe acute respiratory syndrome Nucleotide sequence of the Kaposi sarcoma- associated herpesvirus( HHV8) Human bocavirus: passenger or pathogen in acute respiratory tract infections? |
| cord-018437-yjvwa1ot | What does virus evolution tell us about virus origins? |
| cord-008556-oetrdm8g | Can ACG serve as an initiation codon for protein synthesis in eukaryotic cells? |
| cord-008556-oetrdm8g | How do eucaryotic ribosomes select initiation regions in messenger RNA? |
| cord-008556-oetrdm8g | Poliovirus protease does not mediate cleavage of the 220,000-Da component of the cap binding protein complex Translational control of protein synthesis after infection by VSV VSV mRNA and inhibition of translation of cellular mRNA- is there a P function in VSV? |
| cord-008556-oetrdm8g | What if complementation were to require, in addition to enu, a second minor protein- either a truncated form of enu that initiates a little farther downstream or a small protein encoded in an alternate reading frame? |
| cord-008556-oetrdm8g | What mechanism enables influenza mRNAs to bypass the block that retains host mRNAs in the nucleus? |
| cord-022674-90g0461f | The adsorption of viruses onto filters, and presumably other solid adsorbents as well, is governed both by electrostatic interactions, which predominate at lower pH levels( 14) and by hydrophobic interactions, which predominate at higher pH levels(? |
| cord-017748-xy26tk0t | A virus subtypes with DNA vaccines Protection against avian influenza H9N2 virus challenge by immunization with hemagglutinin- or neuraminidaseexpressing DNA in BALB/ c mice Protection against multiple influenza A subtypes by vaccination with highly conserved nucleoprotein Protection of mice and poultry from lethal H5N1 avian influenza virus through adenovirus- based immunization Development of adenoviral- vector- based pandemic influenza vaccine against antigenically distinct human H5N1 strains in mice Safety and immunogenicity of a recombinant hemagglutinin vaccine for H5 influenza in humans Protection against H1, H5, H6 and H9 influenza A infection with liposomal matrix 2 epitope vaccines Prospects for universal influenza virus vaccine Influenza type A virus escape mutants emerge in vivo in the presence of antibodies to the ectodomain of matrix protein 2 Making better influenza virus vaccines? |
| cord-017748-xy26tk0t | avian H9N2 influenza A virus in Hong Kong in Rapid evolution of H5N1 influenza viruses in chickens in Hong Kong Molecular characterization of H9N2 influenza viruses: were they the donors of the"internal"genes of H5N2 viruses in Hong Kong? |
| cord-017748-xy26tk0t | how prepared are we for a pandemic? |
| cord-020789-slsfhrkx | Bocaviren ist richtig? |
| cord-020789-slsfhrkx | zu Entero- und Rhinoviren ist falsch? |
| cord-017527-ylng1us2 | : how aware are Mammalian cell culturists of the problem and how to monitor it? |
| cord-017527-ylng1us2 | A novel coronavirus associated with SARS Cell culture contamination: an overview Improving the biosafety of cell sorting by adaptation of a cell sorting system to a biosafety cabinet Bovine viral diarrhea virus contamination of nutrient serum, cell cultures and viral vaccines Ocular vaccinia infection in laboratory worker A tale of two clades: monkeypox viruses Molecular cloning and disease association of hepatitis G virus: a transfusion- transmissible agent Infection of laboratory workers with hantavirus acquired from immunocytomas propagated in laboratory rats Cross- species transfer of viruses: implications for the use of viral vectors in biomedical research, gene therapy and as live- virus vaccines Henrietta Lacks, HeLa cells, and cell culture contamination CD4-independent infection by human immunodeficiency virus type I after phenotypic mixing with human T- cell leukemia viruses Where all the cell lines gone? |
| cord-017527-ylng1us2 | Brief report, infections of a laboratory worker with simian immunodeficiency virus How long do nosocomial pathogens persist on inanimate surfaces? |
| cord-022305-uvor9rts | Natural host: Rat; mouse? |
| cord-003232-nquw7qga | An Open Receptor- Binding Cavity of Hemagglutinin- Esterase- Fusion Glycoprotein from Newly- Identified Influenza D Virus: Basis for Its Broad Cell Tropism Metagenomic characterization of the virome associated with bovine respiratory disease in feedlot cattle identified novel viruses and suggests an etiologic role for influenza D virus A metagenomics and case- control study to identify viruses associated with bovine respiratory disease Where have we been, where are we now, and where do we want to go? |
| cord-003232-nquw7qga | In particular, we feel that researchers should focus on answering the key questions,"what is the role of bats in the ecology and evolution of IAVs?","are IDVs involved in the epidemic influenza infections in people?", and"are birds susceptible to infection by IDVs?" |
| cord-003232-nquw7qga | In particular, we feel that researchers should focus on answering the key questions,"what is the role of bats in the ecology and evolution of IAVs?","are IDVs involved in the epidemic influenza infections in people?", and"are birds susceptible to infection by IDVs?" |
| cord-003232-nquw7qga | In particular, we feel that researchers should focus on answering the key questions,"what is the role of bats in the ecology and evolution of IAVs?","are IDVs involved in the epidemic influenza infections in people?", and"are birds susceptible to infection by IDVs?" |
| cord-003232-nquw7qga | In particular, we feel that researchers should focus on answering the key questions,"what is the role of bats in the ecology and evolution of IAVs?","are IDVs involved in the epidemic influenza infections in people?", and"are birds susceptible to infection by IDVs?" |
| cord-003232-nquw7qga | In particular, we feel that researchers should focus on answering the key questions,"what is the role of bats in the ecology and evolution of IAVs?","are IDVs involved in the epidemic influenza infections in people?", and"are birds susceptible to infection by IDVs?" |
| cord-003232-nquw7qga | In particular, we feel that researchers should focus on answering the key questions,"what is the role of bats in the ecology and evolution of IAVs?","are IDVs involved in the epidemic influenza infections in people?", and"are birds susceptible to infection by IDVs?" |
| cord-018058-n3majqes | Since When Have We Known of Viruses?" |
| cord-018058-n3majqes | What Is the Importance of the Henle- Koch Postulates? |
| cord-018058-n3majqes | What Is the Interrelationship Between Virus Research, Cancer Research, Neurobiology and Immunology? |
| cord-017764-h1w9gbxk | An Inhibitor of the Mathematical modeling of HCV infection: what can it teach us in the era of direct- acting antiviral agents? |
| cord-017764-h1w9gbxk | How were new medicines discovered? |
| cord-017764-h1w9gbxk | Impact of highthroughput screening on biomedical research Cell- based assays to identify inhibitors of viral disease Anti- infectives: can cellular screening deliver? |
| cord-017331-ru7mvfc0 | 2009 H1N1 and swine H1N1 and H3N2 triple reassortant influenza viruses Bird life in the National Park A review of West Nile and Usutu virus co- circulation in Europe: how much do transmission cycles overlap? |
| cord-017331-ru7mvfc0 | A study of the hemorrhagic septicemia Pasteurellae Campylobacter jejuni and Proventricular Dilatation Disease in parrots: there may be a correlation? |
| cord-017331-ru7mvfc0 | Les blastomycètes pathogènes Does the roosting behavior of birds affect transmission dynamics of West Nile virus? |
| cord-020235-stcrozdw | Are the sites of insertion of viral DNA specific? 2. |
| cord-020235-stcrozdw | What type of recombinatorial events occur in viral DNA integration? |
| cord-022453-xe5v7947 | The combination of various antiviral monoclonal antibodies with anti- Z?. |
| cord-022947-ruizhgwh | Questions to be answered, with regard to estuarine and marine water standards include:( i) for which activities are water quality standards needed;( ii) are corresponding fresh water indicators adequate and appropriate indicators of health hazards or increased risk of disease arising from the presence of pathogenic organisms of fecal origin; and( iii) are such indicators appropriate and satisfactory, even for fresh water? |
| cord-020969-lh2ergpm | A look to future directions in gene therapy research for monogenic diseases Update on adenovirus and its vectors Herpes simplex virus 1( HSV-1) for cancer treatment Virus vectors and their applications The use of oncolytic vaccinia viruses in the treatment of cancer: A new role for an old ally? |
| cord-020969-lh2ergpm | In addition, the expression needs to continue for the life of the patient, which means either a very stable( integrated?) |
| cord-022830-tvt58gtn | Molecular methods used to estimate thermal inactivation of a prototype human norovirus: more heat resistant than previously believed? |
| cord-017070-05vlz5dn | Neutralizing antibodies in patients with severe acute respiratory syndrome- associated coronavirus infection Antibody responses against SARS- coronavirus and its nucleocaspid in SARS patients Development of a safe neutralization assay for SARS- CoV and characterization of S- glycoprotein SARS corona virus peptides recognized by antibodies in the sera of convalescent cases S protein of severe acute respiratory syndrome- associated coronavirus mediates entry into hepatoma cell lines and is targeted by neutralizing antibodies in infected patients Prior infection and passive transfer of neutralizing antibody prevent replication of severe acute respiratory syndrome coronavirus in the respiratory tract of mice Severe acute respiratory syndrome coronavirus infection of golden Syrian hamsters Replication of SARS coronavirus administered into the respiratory tract of African Green, rhesus and cynomolgus monkeys Treating severe acute respiratory syndrome with hyperimmune globulins SARS: what have we learned? |
| cord-017070-05vlz5dn | The neurological manifestations of Nipah virus encephalitis, a novel paramyxovirus Nipah viral encephalitis or Japanese encephalitis? |
| cord-017070-05vlz5dn | The prospects for vaccines against HIV-1: more than a field of long- term nonprogression? |
| cord-017070-05vlz5dn | and the hMAb combination 4E10/2F5/2G12 Neutralizing antibody responses to HIV: role in protective immunity and challenges for vaccine design Identifying epitopes of HIV-1 that induce protective antibodies Antibodies: can they protect against HIV infection? |
| cord-021413-1ht1xm88 | Infantile enteritis viruses: morphogenesis and morphology Is lactase the receptor and uncoating enzyme for infantile enteritis( rota) viruses? |
| cord-021413-1ht1xm88 | This aspect of reovirus 3 infection has been covered above( Section III, B, l,2a, ¿?). |
| cord-018040-k0h5ejjt | Statements like"What message are we sending to our elementary students when we inoculate them for a sexually transmitted disease in the third grade?" |
| cord-018040-k0h5ejjt | What may be the mechanism of higher immunogenicity exhibited by particulate antigens compared to soluble ones and does the size of these particles matter? |
| cord-018040-k0h5ejjt | Who's afraid of Gardasil? |
| cord-022383-pz0htccp | Excre tion and transmission of virus occurs via the respiratory tract( Jacoby |
| cord-022163-7klzsrpu | Henipavirus and Tioman virus antibodies in pteropodid bats Replication and persistence of measles virus in defi ned subpopulations of human leukocytes Newcastle disease virus- vectored Nipah encephalitis vaccines induce B and T cell responses in mice and long- lasting neutralizing antibodies in pigs Virus infections in the nervous system Effects of canine distemper virus infection on lymphoid function in vitro and in vivo Rhabdovirus- based vaccine platforms against Henipaviruses Eph, a protein family coming of age: more confusion, insight, or complexity? |
| cord-022163-7klzsrpu | The distribution of henipaviruses in Southeast Asia and Australasia: is Wallace's line a barrier to Nipah virus? |
| cord-018555-3lta1tbp | In an evolutionary context, which is where the concept of adaptation lies, why would a symbiont switch to being pathogenic, either at some stage in its life cycle or in some hosts at the same stage but not in others? |
| cord-018555-3lta1tbp | The question arises,"Is becoming a pathogen an adaptation for a symbiont?" |
| cord-018555-3lta1tbp | What if transmission occurs not so much from living infected hosts but from hosts after they die? |
| cord-025995-nxeg03xj | Yaeger and O'Brien[ 55] compared the degree of poliovirus inactiva-? tion in eight different soils saturated with riverwater, groundwater, or septic wastewater and in the same soils that were allowed to dry out during the course of the experiment. |
| cord-018724-ss8x2g3b | How does the genome structure and lifestyle of a virus affect its population variation? |
| cord-018724-ss8x2g3b | Lifestyles of plant viruses Persistent plant viruses: molecular hitchhikers or epigenetic elements? |
| cord-018724-ss8x2g3b | The remarkable evolutionary history of endornaviruses Plant virus metagenomics: advances in virus discovery Metavir 2: new tools for viral metagnome comparison and assembled virome analysis The role of viruses in biological invasions: friend or foe? |
| cord-010248-ln800g5z | How do virus- infected cells activate the alternative pathway? |
| cord-010248-ln800g5z | Since patients'sera enhanced cytotoxicity, these observations are at variance with the earlier report of Ahmed et a,?. |
| cord-010248-ln800g5z | Spontaneous lysis of infected cells in MEM was 5? |
| cord-010248-ln800g5z | The major remaining questions concerning the mechanism of this reaction are as follows: Do cells infected with other viruses activate the alternative pathway? |
| cord-010248-ln800g5z | What is the mechanism by which IgG induces lysis? |
| cord-024188-d7tnku8z | Cloning of a human parvovirus by molecular screening of respiratory tract samples Identification of a third human polyomavirus Human bocavirus and acute wheezing in children Virus discovery by sequence- independent genome amplification Fungal infections in primary immunodeficiencies Frequent detection of human rhinoviruses, paramyxoviruses, coronaviruses, and bocavirus during acute respiratory tract infections Presence of the newly discovered human polyomaviruses KI and WU in Australian patients with acute respiratory tract infection Merkel cell polyomavirus in respiratory specimens: a possible route of transmission? |
| cord-018441-r6wwpfcy | Where did the virus come from? |
| cord-018441-r6wwpfcy | Where did this virus come from and how did it arise? |
| cord-018441-r6wwpfcy | Why did this outbreak occur in 1993? |
| cord-009383-ozx5u0t3 | ( 1996 Roy( what's already available? |
| cord-009383-ozx5u0t3 | ( 2) Will the vectored vaccine give a manufacturing advantage compared to what's already available? |
| cord-009383-ozx5u0t3 | ( 3) Will the vectored vaccine provide improved safety compared to what's already available? |
| cord-009383-ozx5u0t3 | ( 5) Will the vectored vaccine increase the duration of immunity compared to what's already available? |
| cord-009383-ozx5u0t3 | ( 6) Will the vectored vaccine be more convenient to store compared to what's already available? |
| cord-009383-ozx5u0t3 | ( 7) Is the vectored vaccine compatible with other vaccines? |
| cord-027654-k0uby99n | SIVmacinduced immunodefi ciency AAV vectors: is clinical success on the horizon? |
| cord-009836-7o6htufh | -the war being lost What can we learn about human immunodeficiency virus infection from a study of lymphocytic choriomeningitis virus? |
| cord-009836-7o6htufh | : how important are they in viral evasion of immune clearance in vivo? |
| cord-009836-7o6htufh | Chisari FV Hepatitis B virus( HBV) sequence variation in cytotoxic T lymphocyte epitopes is not common in patients with chronic HBV infection Chisari FV Is antigenic variability a strategy adopted by hepatitits B virus to escape cytotoxic T- lymphocyte surveillance? |
| cord-009836-7o6htufh | This patient clearly bad the capacity to make CTL responses to a broad range of epitopes in HIV; why then was his initial response so highly foctised on a single epitope? |
| cord-009836-7o6htufh | Why ca n't cytotoxic T cells handle HIV? |
| cord-009836-7o6htufh | as the host immune response is aiso adaptive, can it in turn evoive in response to the emergence of escape viral variants? |
| cord-026130-ki7bn67o | : What has CT taught us? |
| cord-022354-aqtceqqo | Thus even in this well- defined situation, where an amino acid sequence is known to play a functional role in the sorting process, it can be impossible to predict with confidence its location in the protein; how then might we expect to identify additional sorting sequences that may or may not exist within the structural domain of a transported protein? |
| cord-022354-aqtceqqo | What then is the function of the cytoplasmic domain of the env glycoprotein? |
| cord-014397-7b88ycv8 | A sialoglycopeptide from human erythrocytes with receptor- like properties for encephalomyocarditis and influenza viruses Resistance in transgenic tobacco plants expressing a nonstructural gene sequence of tobacco mosaic virus is a consequence of markedly reduced virus replication Does the beta- andrenergic factor receptor function as reovirus receptor? |
| cord-014397-7b88ycv8 | Determinants essential for the transmissible gastroenteritis virus receptor interaction reside within a domain of aminopeptidase N that is distinct from the enzymatic site Molecular characterization of gene- for- gene systems in plant fungus interactions and the application of avirulence genes in control of plant pathogens Risk assessment: do we let history repeat itself? |
| cord-014397-7b88ycv8 | Plant viral resistance Will transgenic crops generate new viruses and new diseases? |
| cord-014397-7b88ycv8 | The mammalian cell- virus relationship Attachment of poliovirus to cultivated cells of primate and nonprimate origin Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily Binding to sialic acids is not an essential step for entry of animal rotaviruses to epithelial cells in culture Genetic exchange between bacteriophage T4 and filamentous fungi? |
| cord-014397-7b88ycv8 | Why did certain mechanisms develop and others not? |
| cord-003466-599x0euj | Outflanking antibody Immunodominance on the road to universal influenza vaccination Is it possible to develop a"universal"influenza virus vaccine? |
| cord-003466-599x0euj | Potential for a universal influenza vaccine Is it possible to develop a"universal"influenza virus vaccine? |
| cord-003466-599x0euj | Potential target antigens and critical aspects for a universal influenza vaccine Is it possible to develop a"universal"influenza virus vaccine? |
| cord-003466-599x0euj | The next influenza pandemic: can it be predicted? |
| cord-003466-599x0euj | Universal influenza vaccines: to dream the possible dream? |
| cord-003466-599x0euj | Universal vaccines and vaccine platforms to protect against influenza viruses in humans and agriculture Is it possible to develop a"universal"influenza virus vaccine? |
| cord-003466-599x0euj | What can we learn from reconstructing the extinct 1918 pandemic influenza virus? |
| cord-022393-s26d54ew | A new zoonosis? |
| cord-022393-s26d54ew | In Principles and practices of infectious diseases Laboratory animal allergy in a pharmaceutical company Important animal allergens are lipocalin proteins: why are they allergenic? |
| cord-021894-lq8yr710 | A clustering approach to identify severe bronchiolitis profiles in children Deciphering clinical phenotypes in acute viral lower respiratory tract infection: bronchiolitis is not an island Variability in the diagnostic labeling of nonbacterial lower respiratory tract infections: a multicenter study of children who presented to the emergency department South African guideline for the diagnosis, management and prevention of acute viral bronchiolitis in children Rapid point of care diagnostic tests for viral and bacterial respiratory tract infections- needs, advances, and future prospects Co- infections in children hospitalised for bronchiolitis: role of roomsharing Antibiotics for bronchiolitis in children under two years of age High incidence of pulmonary bacterial co- infection in children with severe respiratory syncytial virus( RSV) bronchiolitis Pulmonary and systemic bacterial co- infections in severe RSV bronchiolitis Concurrent bacterial infection and prolonged mechanical ventilation in infants with respiratory syncytial virus lower respiratory tract disease Nasogastric hydration versus intravenous hydration for infants with bronchiolitis: a randomised trial Oxygen saturation targets in infants with bronchiolitis( BIDS): a double- blind, randomised, equivalence trial Predictors of major intervention in infants with bronchiolitis Intermittent monitoring of oxygen saturation in infants and children with acute bronchiolitis: peekaboo pediatrics or good clinical care? |
| cord-021894-lq8yr710 | The G glycoprotein of respiratory syncytial virus depresses respiratory rates through the CX3C motif and substance P Risk factors for requiring intensive care among children admitted to ward with bronchiolitis Effect of oxygen supplementation on length of stay for infants hospitalized with acute viral bronchiolitis Hospital course and discharge criteria for children hospitalized with bronchiolitis Inter- observer agreement between physicians, nurses, and respiratory therapists for respiratory clinical evaluation in bronchiolitis Bronchiolitis: recommendations for diagnosis, monitoring and management of children one to 24 months of age Is nasal suctioning warranted before measuring O2 saturation in infants with bronchiolitis? |
| cord-021894-lq8yr710 | The burden of respiratory syncytial virus infection in young children Hospitalizations associated with influenza and respiratory syncytial virus in the United States Increased risk of wheeze and decreased lung function after respiratory syncytial virus infection G489 blood gas analysis in acute bronchiolitis- who and when? |
| cord-027473-8zerjwa0 | First respiratory transmitted food borne outbreak? |
| cord-009615-xcz8m9a7 | An electron microscopic study Are astrocytes infected in progressive multifocal leukoencephalopathy( PML)? |
| cord-009615-xcz8m9a7 | Can they also be accommodated by a latent- virus model? |
| cord-009615-xcz8m9a7 | Could brain infection with a latent virus capable of limited reactivation in glial cells explain this wealth of data? |
| cord-009615-xcz8m9a7 | Is it time to change the paradigm? |
| cord-009615-xcz8m9a7 | Sclerose en plaques et gliome cerebral Glioblastoma associated with multiple sclerosis: Coincidence or induction? |
| cord-009615-xcz8m9a7 | The development of rational strategies for selective immunotherapy against autoimmune demyelinating disease T cell vaccination in multiple sclerosis: A preliminary report Multiple sclerosis: Additional thoughts Debate: Do TCR genes influence susceptibility to autoimmune disease in humans? |
| cord-009615-xcz8m9a7 | What would determine whether a latent virus infection remains entirely benign, or erupts as a chronic demyelinating disease such as MS? |
| cord-025181-eg108wcd | But, type I interferon are vital for CD4? |
| cord-025181-eg108wcd | and CD8? |
| cord-048368-wm4c7rk6 | Until 2005 avian influenza was regional problem of sev-[ 4] and question"why had only some wild waterfowl died?"is still unclear. |
| cord-103688-n7hzpbyf | What is Blockchain Technology and its Significance in the Current Healthcare System? |
| cord-016171-17ut32bu | : why smallpox? |
| cord-016171-17ut32bu | Did bioweapons test cause a deadly smallpox outbreak? |
| cord-016171-17ut32bu | The general made this suggestion in July 1763, as strategy against tribes near Fort Pitt, Pennsylvania, involved in Pontiac's Rebellion:"Could it not be contrived to send a small pox among the disaffected tribes of Indians?" |
| cord-016171-17ut32bu | Two funeral- associated smallpox outbreaks in Sierra Leone Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox Exploring the potential of variola virus infection of cynomolgus macaques as a model for human smallpox Terrorists'most likely weapon here? |
| cord-016171-17ut32bu | What should be done to reduce the threat of smallpox further? |
| cord-102383-m5ahicqb | Human interactome of the influenza B virus NS1 protein Whither systems medicine? |
| cord-214795-8jweuq50 | A deep matrix factorization method for learning attribute representations Arbidol: A potential antiviral drug for the treatment of SARS- CoV-2 by blocking the trimerization of viral spike glycoprotein? |
| cord-017537-ztdz4a2s | Are we many on Earth? |
| cord-017537-ztdz4a2s | Is there enough work for the immune system of each living multicellular organism to distinguish"self"from possibly harmful"not self"? |
| cord-017537-ztdz4a2s | The basic question is: when the new pandemic will strike? |
| cord-017537-ztdz4a2s | There are no longer cases detected in the world population since 1990, but can we destroy the samples of smallpox virus existing in some virology laboratories around the world? |
| cord-017537-ztdz4a2s | Today, how scared should we be of biological and chemical terrorism? |
| cord-030961-5gzc7193 | Influenza virus binds its host cell using multiple dynamic interactions How does a virus bud? |
| cord-007417-az8xd66p | : Is there a link? |
| cord-007417-az8xd66p | A critical role for dendritic cells? |
| cord-007417-az8xd66p | A prospective cohort study Are rhinovirus- induced airway responses in asthma aggravated by chronic allergen exposure? |
| cord-007417-az8xd66p | Enhanced pulmonary histopathology is observed in cotton rats immunized with formalin- inactivated respiratory syncytial virus( RSV) or purified F glycoprotein and challenged with RSV 3- 6 months after immunization Allergens, viruses, and asthma exacerbations Gender analysis in acute bronchiolitis due to respiratory syncytial virus Age and sex as factors of response to RSV infections among those with previous history of wheezing Nerve growth factor: The central hub in the development of allergic asthma? |
| cord-007417-az8xd66p | The antibody response to primary and secondary infection with respiratory syncytial virus: Kinetics of class- specific responses Relationship between respiratory syncytial virus bronchiolitis and future obstructive airway diseases Phenotypes in asthma: Useful guides for therapy, distinct biological processes, or both? |
| cord-007417-az8xd66p | The cold case: Are rhinoviruses perfectly adapted pathogens? |
| cord-007417-az8xd66p | The first sign of childhood asthma? |
| cord-252456-971d0sir | Pathog Dis Novel coronavirus takes flight from bats? |
| cord-027752-xcpv9k22 | Has not the time arrived to launch a campaign and to come to grips with the enemy? |
| cord-027752-xcpv9k22 | Is it too much to ask that work on similar lines be undertaken on the cause of influenza? |
| cord-017364-d9zmdm23 | Does severe RSV disease cause asthma? |
| cord-017364-d9zmdm23 | Is there a genetic basis for susceptibility to severe disease? |
| cord-017364-d9zmdm23 | What are the defi nitive mechanisms of immunity in humans? |
| cord-017364-d9zmdm23 | What drives the seasonality of RSV? |
| cord-017364-d9zmdm23 | Why does reinfection occur throughout life? |
| cord-023608-w2g7v7g1 | Or perhaps the( immuno)pathology of virus infections may boost some specific enzyme reactions in the infected organs? |
| cord-023608-w2g7v7g1 | So perhaps it is time to consider some less explored scaffolds in the search for new nucleos(t)ide antivirals? |
| cord-023608-w2g7v7g1 | Why is then the structural diversity of antiviral nucleos(t)ide drugs still quite limited? |
| cord-022960-u4s23x1r | Why is this study important? |
| cord-022960-u4s23x1r | Why is this study important? |
| cord-022960-u4s23x1r | Why is this study important? |
| cord-021990-a8ku5rke | Did the person attend parties where large amounts of alcohol and/ or drugs were consumed( e.g.,"spring break"in the USA)? |
| cord-021990-a8ku5rke | Did the person travel to countries where sex workers are readily available? |
| cord-021990-a8ku5rke | If the traveler is strongly suspected of having an STD, did he/ she visit a destination where chancroid, granuloma inguinale( GI), or lymphogranuloma venereum( LGV)( L serovars of Chlamydia trachomatis) is prevalent? |
| cord-021990-a8ku5rke | Was the person traveling without his/ her spouse/ family and therefore outside his/ her usual social structure? |
| cord-254200-9bpdfxrt | First report of human immunodeficiency virus transmission via an RNA- screened blood donation Failure and success of HIV tests for the prevention of HIV transmission by blood and tissue donations Large- scale screening for human parvovirus B19 DNA by PCR: application to the quality control of plasma for fractionation Heparan sulfate: anchor for viral intruders? |
| cord-171099-d0qr84xg | A series of PDB related databases for everyday needs Structure and stability of the lamin A tail domain and HGPS mutant Evaluating Hierarchical Structure in Music Annotations Sounds interesting: can sonification help us design new proteins? |
| cord-018639-0g1ov96t | An interdisciplinary approach to analysing the bushmeat trade in central and west Human demography and reserve size predict wildlife extinction in West Africa Economic and geographic drivers of wildlife consumption in rural Africa Is the best the enemy of the good? |
| cord-018639-0g1ov96t | The historical question of acquired immunodefi ciency syndrome in the 1960s in the Congo River basin area in relation to cryptococcal meningitis Could risk of disease change bushmeat- butchering behavior? |
| cord-018639-0g1ov96t | The threat to primates and other mammals from the bushmeat trade in Africa, and how this threat could be diminished 1 Economic commodity or environmental crisis? |
| cord-018639-0g1ov96t | Why do Mbuti hunters use nets? |
| cord-018639-0g1ov96t | a disease risk worth taking to put food on the table? |
| cord-252147-bvtchcbt | Is declining innovation in the pharmaceutical industry a myth? |
| cord-023092-unjv71qv | Are the animals with a titre of 1,600 at a higher risk to contract FIP than those with the lower titres? |
| cord-023092-unjv71qv | How is it possible that this kitten has been infected? |
| cord-023092-unjv71qv | Which measures are to be recommended? |
| cord-102908-sr7j8z9c | One, two or three? |
| cord-102908-sr7j8z9c | We used differential binary labelling and statistical modelling to extract estimates of stoichiometry, our strategy is outlined in Figure 1; note that this approach can be generalised to apply to many other multi- component systems( i.e. how many protein x are found in assembly y?). |
| cord-016475-7ldxvbpz | Are we ready for pandemic influenza? |
| cord-016475-7ldxvbpz | Attenuated Or Inactivated Influenza- A Virus- Vaccine Caspases: the executioners of apoptosis Protein kinases-- the major drug targets of the twenty- first century? |
| cord-016475-7ldxvbpz | GG167 Influenza Study Group Safety and efficacy of the neuraminidase inhibitor GG167 in experimental human influenza Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza: randomized controlled trials for prevention and treatment MAPK- regulated transcription: a continuously variable gene switch? |
| cord-016475-7ldxvbpz | In vitro characterization of A-315675, a highly potent inhibitor of A and B strain influenza virus neuraminidases and influenza virus replication Novel generations of influenza vaccines Cold- adapted live attenuated influenza vaccines developed in Russia: can they contribute to meeting the needs for influenza control in other countries? |
| cord-016475-7ldxvbpz | Influenza: emergence and control Preparation of a standardized, efficacious agricultural H5N3 vaccine by reverse genetics Effective construction of DNA vaccines against variable influenza genes by homologous recombination Influenza virus induction of apoptosis by intrinsic and extrinsic mechanisms Influenza virus- induced AP-1-dependent gene expression requires activation of the JNK signaling pathway Influenza- virus- induced signaling cascades: targets for antiviral therapy? |
| cord-016475-7ldxvbpz | The influenza B virus nonstructural NS1 protein is essential for efficient viral growth and antagonizes beta interferon induction A pandemic warning? |
| cord-255479-yd5cbwnx | Notes from the field: chikungunya virus spreads in the Americas-Caribbean and South America Number of reported cases of chikungunya fever in the Americas, by country or territory 2013- 2014 cumulative cases Chikungunya and dengue: a case of mistaken identity? |
| cord-254592-wa5il5go | The Lancet Estimates of Ebola virus case- fatality ratio in the 2014 West African outbreak Current knowledge on lower virulence of Reston Ebola virus Prediction and prevention of the next pandemic zoonosis Host- parasite relations, vectors, and the evolution of disease severity Pathogen survival in the external environment and the evolution of virulence Mechanisms of pathogenesis, infective dose and virulence in human parasites Challenging the trade- off model for the evolution of virulence: is virulence management feasible? |
| cord-255137-utg8k7qs | The ascension of wildlife rabies: a cause for public health concern or intervention? |
| cord-253825-d9borky8 | a broad- spectrum antiviral compound that blocks viral fusion Arbidol: a broad- spectrum antiviral that inhibits acute and chronic HCV infection Similar uptake but different trafficking and escape routes of reovirus virions and ISVPs imaged in polarized MDCK cells Design of inhibitors of influenza virus membrane fusion: synthesis, structure- activity relationship and in vitro antiviral activity of a novel indole series Antiviral activity of arbidol, a broad- spectrum drug for use against respiratory viruses, varies according to test conditions Antiviral chemotherapeutic agents against respiratory viruses: where are we now and what's in the pipeline? |
| cord-252048-ftbjsoup | Coronavirus avian infectious bronchitis virus Infectious bronchitis virus-evidence for recombination within the massachusetts serotype Infectious bronchitis Does IBV change slowly despite the capacity of the spike protein to vary greatly? |
| cord-161674-nk0wie0w | So Far? |
| cord-161674-nk0wie0w | The role of microRNAs in respiratory viral infection: friend or foe? |
| cord-256325-q70rky3r | This raises the question: do henipavirus M proteins traffic through the nucleolus for other reasons? |
| cord-255690-xc4bxin4 | chloroquine based ARV regimen combined with hydroxyurea and lamivudine: a new economical triple therapy Therapeutic potential of chloroquine added to zidovudine plus didanosine for HIV-1 infected children Mother- tochild transmission of HIV-1: timing and implications for prevention Effects of chloroquine on viral infections: an old drug against today's diseases? |
| cord-000114-f0vud3gu | A single amino- acid in the Pb2-gene of influenza- a virus is a determinant of host range Duck migration and past influenza A( H5N1) outbreak areas Highly pathogenic avian influenza H5N1 Spring migration of Northern Pintails from California's Central Valley wintering area tracked with satellite telemetry: routes, timing, and destinations Highly pathogenic avian influenza virus( H5N1) isolated from whooper swans Wet markets-a continuing source of severe acute respiratory syndrome and influenza? |
| cord-000114-f0vud3gu | Can the use of transgenic animals containing the natural resistance gene(s) of mallard ducks prevent pathogenic influenza virus infection? |
| cord-000114-f0vud3gu | Distribution patterns and biological significance Are ducks contributing to the endemicity of highly pathogenic H5N1 influenza virus in Asia? |
| cord-000114-f0vud3gu | Do ducks( wild or domestic) serve as the reservoirs of the Asian H5N1 HPAI viruses? |
| cord-000114-f0vud3gu | Is antigenic diversity driven naturally in ducks or is it the consequence of vaccine usage? |
| cord-000114-f0vud3gu | Is eradication of Asian H5N1 HPAI viruses achievable? |
| cord-000114-f0vud3gu | The immunogenicity and efficacy against H5N1 challenge of reverse genetics- derived H5N3 influenza vaccine in ducks and chickens Intestinal influenza: replication and characterization of influenza viruses in ducks Persistence of avian influenza viruses in water Water- borne transmission of influenza A viruses? |
| cord-000114-f0vud3gu | What dose of vaccine antigen is required to prevent transmissible levels of excretion of H5N1 HPAI viruses by ducks of different species( and geese and swans)? |
| cord-000114-f0vud3gu | What genomic characteristics of ducks are associated with natural resistance in some species? |
| cord-018164-h5k1zsyg | Are Viruses Alive? |
| cord-018164-h5k1zsyg | How Are Viruses Spread? |
| cord-018164-h5k1zsyg | Is a bean seed alive? |
| cord-018164-h5k1zsyg | Were these genes derived from the host cell since they mimic host functions and interfere with these functions, or were they acquired by the host eons ago from the virus? |
| cord-018164-h5k1zsyg | What Is a Virus? |
| cord-018164-h5k1zsyg | Where did those mimicking genes come from? |
| cord-256837-100ir651 | how does HIV-1 exacerbate tuberculosis? |
| cord-255697-trig04hd | How long do nosocomial pathogens persist on inanimate surfaces? |
| cord-256510-orr2roxz | Do viruses subvert cholesterol homeostasis to induce host cubic membranes? |
| cord-022822-7346069t | Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus Respiratory syncytial virus-viral biology and the host response Immune Responses and Disease Enhancement during Respiratory Syncytial Virus Infection'The beta2 integrin CD11c distinguishes a subset of cytotoxic pulmonary T cells with potent antiviral effects in vitro and in vivo Asthma as a risk factor for invasive pneumococcal disease Chlamydophila pneumoniae and Mycoplasma pneumoniae: a role in asthma pathogenesis?'. |
| cord-022822-7346069t | How is virus induced inflammation and antiviral immunity regulated at the molecular and cellular level and can targets for the development of new therapies be identified by better understanding these mechanisms? |
| cord-022822-7346069t | What are the roles of and interactions between innate and acquired immune responses in inducing wheezing in response to viral and bacterial respiratory infection in infants who may be predisposed to, or individuals who have developed asthma? |
| cord-022822-7346069t | and/or bacteria induced pathology in wheezing illness, both as a result of failure of clearance and of potentially immunopathogenic immune responses? |
| cord-023678-9q68ftr9 | Does a tissue culture monolayer show CPE? |
| cord-023678-9q68ftr9 | Has an animal died? |
| cord-023678-9q68ftr9 | Is an egg infected? |
| cord-023678-9q68ftr9 | It is thus a quantal assay in that each tube provides only one piece of information, i.e., is there CPE or not? |
| cord-255075-6azu6k3h | A one- size- fits- all flu vaccine? |
| cord-255075-6azu6k3h | What's the point? |
| cord-257321-l1swyr6g | A comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special? |
| cord-021465-2pj26fmv | The chicken MHC complex Common antigenicity of avian reoviruses Is the gene pool of influenza viruses in shorebirds and gulls different from that in wild ducks? |
| cord-021465-2pj26fmv | The ecology of influenza viruses in ducks and analysis of influenza viruses with monoclonal antibodies Are seals frequently infected with avian influenza viruses? |
| cord-021465-2pj26fmv | The viruses of the future? |
| cord-021465-2pj26fmv | This may be true under truly"natural"conditions; but what happens under human- dictated conditions such as vaccination and by defining the host population through breeding and housing? |
| cord-021465-2pj26fmv | What viruses other than the orthomyxoviruses may someday establish a similar relationship where transmission to a mammalian intermediate or even direct transmission may allow introduction into the human population? |
| cord-022439-8wy7rpqv | Antibody- all relevant epitopes recognized? |
| cord-022439-8wy7rpqv | Interferon induction in interstitial cells? |
| cord-022439-8wy7rpqv | Molecular mimicry: frequency of reac tivity of monoclonal antiviral antibodies with normal tissues Monoclonal antibody to coxsackievirus B reacts with myocardium Polymyositis and molecular mimicry: a mechanism of auto immunity On the use of se quence homologies to predict protein structure: Identical pentapeptides can have completely different conformations Which structural features determine protein antigenicity? |
| cord-022439-8wy7rpqv | Receptor availability? |
| cord-022439-8wy7rpqv | la antigens? |
| cord-102704-wfuzk2dp | An open- source platform for biological- image analysis Rabies transmitted by vampire bats to humans: an emerging zoonotic disease in Latin 594 America? |
| cord-102704-wfuzk2dp | Serological investigation of rabies virus neutralizing antibodies in bats captured in 469 the eastern Brazilian Amazon One Health, emerging infectious diseases and 472 wildlife: two decades of progress? |
| cord-102704-wfuzk2dp | What do they mean for rabies epidemiology? |
| cord-257299-z9u12yqb | Can mumps vaccine induce remission in recurrent respiratory papilloma? |
| cord-020756-d9f5fd7x | H5N1 Virus Attachment to Lower Respiratory Tract Importance of conserved amino acids at the cleavage site of the haemagglutinin of a virulent avian influenza A virus Are we ready for pandemic influenza? |
| cord-020756-d9f5fd7x | Molecular characterization of H9N2 influenza viruses: were they the donors of the"internal"genes of H5N1 viruses in Hong Kong? |
| cord-020756-d9f5fd7x | Nonhomologous recombination between the hemagglutinin gene and the nucleoprotein gene of an influenza virus Influenza A pandemics of the 20th century with special reference to 1918: virology, pathology and epidemiology Virus- neutralizing antibodies of immunoglobulin G( IgG) but not of IgM or IgA isotypes can cure influenza virus pneumonia in SCID mice Functional anatomy of human lacrimal duct epithelium Human infection with influenza H9N2 Cocirculation of avian H9N2 and contemporary"human"H3N2 influenza A viruses in pigs in southeastern China: potential for genetic reassortment? |
| cord-020756-d9f5fd7x | Recent human influenza A( H1N1) viruses are closely related genetically to strains isolated in 1950 Human influenza virus hemagglutinin with high sensitivity to proteolytic activation Avian influenza and sialic acid receptors: more than meets the eye? |
| cord-020756-d9f5fd7x | Will vaccines be available for the next influenza pandemic? |
| cord-259627-8stewshp | photoantimicrobials for blood product disinfection? |
| cord-257255-n5o368ih | The magnitude of the global problem of diarrhoeal disease: a ten year update Handwashing to prevent diarrhoea in day- care centres Viral gastroenteritis How hygienic should our homes be? |
| cord-254194-962vynwk | A hazardous threat to the environment and human health? |
| cord-254194-962vynwk | Does the antibacterial activity of silver nanoparticles depend on the shape of the nanoparticle? |
| cord-252012-hdjbxah8 | Do rhinoviruses reduce the probability of viral co- detection during acute respiratory tract infections? |
| cord-252012-hdjbxah8 | a review and discussion of their role in infection Evidence of human bocavirus circulating in children and adults Bocavirus infection in hospitalized children Human bocavirus: a novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand Clinical characteristics of human bocavirus infections compared with other respiratory viruses in Spanish children Human bocavirus detection in nasopharyngeal aspirates of children without clinical symptoms of respiratory infection Human bocavirus infection in young children in the United States: molecular epidemiological profile and clinical characteristics of a newly emerging respiratory virus Human bocavirus in Italian patients with respiratory diseases Epidemiological profile and clinical associations of human bocavirus and other human parvoviruses Sole pathogen in acute bronchiolitis: is there a role for other organisms apart from respiratory syncytial virus? |
| cord-252012-hdjbxah8 | the viruses and their replication Sialic acid species as a determinant of the host range of Influenza A viruses Influenza virus and acute asthma in children Is influenza vaccination in asthma helpful? |
| cord-258489-pyfc7jde | Cowpea mosaic virus- based systems for the production of antigens and antibodies in plants Is the infiltration- centrifugation technique appropriate for the isolation of apoplastic fluid? |
| cord-018364-b06084r1 | ( 1) Is the traveler febrile?;( 2) Is the traveler demonstrating symptoms of Ebola?; and( 3) Has the traveler marked"yes"to any questions on the health declaration form? |
| cord-018364-b06084r1 | ( 1) Is the traveler febrile?;( 2) Is the traveler demonstrating symptoms of Ebola?; and( 3) Has the traveler marked"yes"to any questions on the health declaration form? |
| cord-018364-b06084r1 | ( 1) Is the traveler febrile?;( 2) Is the traveler demonstrating symptoms of Ebola?; and( 3) Has the traveler marked"yes"to any questions on the health declaration form? |
| cord-018364-b06084r1 | Are these same numbers valid for travelers or should different cut offs be used? |
| cord-018364-b06084r1 | In theory, this is an excellent regulation, but how can millions of travelers be efficiently screened and detained if needed? |
| cord-018364-b06084r1 | Lastly, what determines what constitutes a fever? |
| cord-259927-xh9cw9ao | Can a school- based hand hygiene program reduce asthma exacerbations among elementary school children? |
| cord-257008-7q5s1vu1 | Can the legacy of industrial pollution influence antimicrobial resistance in estuarine sediments? |
| cord-022252-9yiuuye3 | ( An era of new'magic bullets'?) |
| cord-022252-9yiuuye3 | Could it be that host responses to LPS are, like the complement or the clotting systems, useful in moderation but harmful in excess? |
| cord-022252-9yiuuye3 | Cytolytic pore- forming proteins and peptides: is there a common structural motif? |
| cord-022252-9yiuuye3 | How does CT work? |
| cord-022252-9yiuuye3 | What is the role played by Shiga toxin? |
| cord-256917-6h1ip37z | : Can we win against pathogenic viruses? |
| cord-256917-6h1ip37z | The reproductive number of COVID-19 is higher compared to SARS coronavirus COVID-19, SARS and MERS: are they closely related? |
| cord-257019-lj1yzjn0 | Are antigenic changes involved in measles virus persistence? |
| cord-257019-lj1yzjn0 | Would you interpret from that data that those immunoglobulins were not directed to similar viral constituents because of the disparity in the response seen but indeed that some of those responses were directed at different, presumably oligo, determinants? |
| cord-257652-ndt8f812 | What does virus evolution tell us about virus origins? |
| cord-255339-oudj079q | An undescribed virus disease of sheep cattle and man from East Africa Has Rift Valley fever virus evolved with increasing severity in human populations in East Africa? |
| cord-255339-oudj079q | Will Egypt be the epicenter of the next influenza pandemic? |
| cord-262722-cz3ce29n | Nanometer calibration particles: what is available and what is needed? |
| cord-260168-rb7j94dh | Diff erential expression of chemokines and their receptors in adult and neonatal macrophages infected with human or avian infl uenza viruses Induction of proinfl ammatory cytokines in human macrophages by infl uenza A( H5N1) viruses: a mechanism for the unusual severity of human disease? |
| cord-255181-du6rqc6i | -a threat under control? |
| cord-255181-du6rqc6i | Wet markets-a continuing source of severe acute respiratory syndrome and influenza? |
| cord-261160-g92zhv19 | Lactate dehydrogenase- elevating virus: an ideal persistent virus? |
| cord-258333-jmk8hdk2 | Can respiratory syncytial virus and influenza A be distinguished clinically in institutionalized older persons? |
| cord-258333-jmk8hdk2 | Respiratory syncytial virus or influenza? |
| cord-035163-tqh5wv12 | Aside from the characteristics described in Table 1, what other commonalities exist for these emerging/ re- emerging zoonotic viruses? |
| cord-035163-tqh5wv12 | Can we use these commonalities as the basis for proposing approaches for IPAC? |
| cord-035163-tqh5wv12 | How can airborne transmission of COVID-19 indoors be minimized? |
| cord-035163-tqh5wv12 | Survival characteristics of airborne human coronavirus Should test methods for disinfectants use vertebrate virus dried on carriers to advance virucidal claims? |
| cord-258783-ev0h95b9 | The hemagglutinin of canine distemper virus determines tropism and cytopathogenicity Host- virus specificity of morbilliviruses predicted by structural modeling of the marine mammal SLAM, a receptor Canine distemper virus- A morbillivirus in search of new hosts? |
| cord-020712-l9cn0n99 | As a conventional measure to show the difference in the pH dependence, the pH at half- maximal fusion, pH,,?. |
| cord-020712-l9cn0n99 | Is phosphatidylserine a VSV binding site? |
| cord-020712-l9cn0n99 | Is the primary sequence also essential for the fusion function? |
| cord-020712-l9cn0n99 | L'irolog? |
| cord-020712-l9cn0n99 | Lateral mobility of band 3 proteins in erythrocyte membranes is largely restricted under physiological conditions; the diffusion constant is of the order of cm? |
| cord-020712-l9cn0n99 | Proteolytic cleavage of the E? glycoprotein of murine Coronavirus: Activation of cell- fusing activity of virions by trypsin and separation of two different YOK cleavage |
| cord-020712-l9cn0n99 | Why is a specific amino acid sequence of F glycoprotein required for the membrane fusion reaction between envelope of HVJ( Sendai virus) and target cell membranes? |
| cord-260496-s2ba7uy3 | Such genomic divergences both maintain viral specificity and allow the emergence of new families raising the question: are these divergences selected by the specificity or are they specificityselectors while maintaining the viral integrity? |
| cord-018017-c8myq6bi | If infections are the greatest threat to human life, they should be critical drivers of evolution? |
| cord-018017-c8myq6bi | In fact, why study anything that is not the most highly impactful area? |
| cord-018017-c8myq6bi | Most prominent was, why study an area of science that has no significant impact? |
| cord-018017-c8myq6bi | On which disease should we focus? |
| cord-018017-c8myq6bi | This question demands a definition, what constitutes high impact? |
| cord-018017-c8myq6bi | What presents the greatest threat to human life today? |
| cord-018017-c8myq6bi | Why not? |
| cord-076082-4kpkhz0o | Can cats spread avian flu? |
| cord-076082-4kpkhz0o | Could cats, or other non- avian species, have played a role in spreading the reassortant viruses in Java? |
| cord-076082-4kpkhz0o | Similarly, could cats act as amplifying hosts facilitating viral expansion and cross- species transmission, as civets did in the SARS outbreaks[ 52]? |
| cord-076082-4kpkhz0o | What factors have contributed to the apparent difference in the growth of genetic diversity? |
| cord-259260-qcfgigga | Vimentin: Central hub in EMT induction? |
| cord-263245-2qub96mz | , the new European test virus for enveloped viruses Can vaccinia virus be replaced by MVA virus for testing virucidal activity of chemical disinfectants? |
| cord-261417-4pf5nsw2 | Noncoding RNA- guided recruitment of transcription factors: A prevalent but undocumented mechanism? |
| cord-016663-qnp99m7o | And drinking camel urine? |
| cord-016663-qnp99m7o | And pisse? |
| cord-016663-qnp99m7o | But what about Paris? |
| cord-016663-qnp99m7o | Is a trench a"place"? |
| cord-016663-qnp99m7o | Is translation really needed? |
| cord-016663-qnp99m7o | Now the disease is well known, but where did it arise and how did it get its unusual name? |
| cord-016663-qnp99m7o | What could be the connection between the vitamins essential to our health, a Polish biochemist, and camel dung in the Middle East? |
| cord-016663-qnp99m7o | What is this toponymous disease that many health professionals have never heard of? |
| cord-016663-qnp99m7o | Where else but the Middle East do humans live in close communion with camels? |
| cord-257553-479x7av6 | 95 Cluster of cases of severe acute respiratory syndrome among Toronto healthcare workers after implementation of infection control precautions: a case series Which preventive measures might protect health care workers from SARS? |
| cord-257553-479x7av6 | Early treatment improves outcomes in acute hepatitis C virus infection: a meta- analysis Two drugs or three? |
| cord-262748-v4xue7ha | Virus membrane- fusion proteins: more than one way to make a hairpin Can self- inhibitory peptides be derived from the interfaces of globular protein- protein interactions? |
| cord-263165-bv4dh9eu | m klinischen Verlauf der Coronavirusinfektion der Schweine Lactogenic immunity to transmissible gastroenteritis of swine Relationship among transmissible gastroenteritis virus antibody titers in serum, colostrum, and milk from vaccinated sows, and protection in their suckling pigs Isolation of a porcine respiratory, non- enteric, coronavirus related to transmissible gastroenteritis New porcine coronavirus? |
| cord-263315-g7os15m1 | Can Anopheles Gambiae Be Infected with Wolbachia Pipientis? |
| cord-263157-8jin6oru | However, an important question arose from these pioneer studies: is the virion- associated incoming genomic viral RNA targeted by RNAi? |
| cord-261241-eqf6ame6 | Excess mortality among the elderly in 12 European countries Increased risk of noninfluenza respiratory virus infections associated with receipt of inactivated influenza vaccine Does viral interference affect spread of influenza? |
| cord-008716-38sqkh9m | Are there immunological consequences of passive immunoprophylaxis? |
| cord-008716-38sqkh9m | Cytotoxic T- cell immunity to influenza Does prematurity alter the course of respiratory syncytial virus infection? |
| cord-008716-38sqkh9m | Given these experiences, could we expect another new strain to behave differently today? |
| cord-008716-38sqkh9m | Negative- strand virus M and retrovirus MA proteins: all in a family? |
| cord-008716-38sqkh9m | Prevalence of various respiratory viruses in the middle ear during acute otitis media A longitudinal study of respiratory viruses and bacteria in the etiology of acute otitis media with effusion Recovery of a new agent from patients with acute respiratory disease Characterization of the influenza A virus gene pool in avian species in southern China: was H6N1 a derivative or a precursor of H5N1? |
| cord-008716-38sqkh9m | The IMpact- RSV Study Group Molecular characterization of H9N2 influenza viruses: were they the donors of the'internal'genes of H5N1 viruses in Hong Kong? |
| cord-008716-38sqkh9m | What are our options for vaccination against potentially pandemic viruses? |
| cord-008716-38sqkh9m | What are the general principles underlying vaccine development for these viruses? |
| cord-008716-38sqkh9m | What are the viruses with pandemic potential? |
| cord-008716-38sqkh9m | What quantity of antiviral drugs is available for emergency use? |
| cord-008716-38sqkh9m | Which vaccines are available? |
| cord-265445-bazcczdj | Impaired immune response in severe human lower tract respiratory infection by respiratory syncytial virus Comparison of virological profiles of respiratory syncytial virus and rhinovirus in acute lower tract respiratory infections in very young Chilean infants, according to their clinical outcome Pandemic A(H1N1)2009 influenza virus detection by real time RT- PCR: is viral quantification useful? |
| cord-263764-2ewz8ok4 | How contagious are common respiratory tract infections? |
| cord-259235-p0yj9qug | The severe acute respiratory syndrome Chikungunya in the Americas Zika virus: following the path of dengue and chikungunya? |
| cord-259235-p0yj9qug | key: cord-259235-p0yj9qug authors: de Lamballerie, Xavier title: Diagnostic et traitement des viroses émergentes: comment aller de l’avant? |
| cord-260705-huyyw5z6 | How do viruses interact with stress- associated RNA granules? |
| cord-260705-huyyw5z6 | Virus factories: Associations of cell organelles for viral replication and morphogenesis A guide to viral inclusions, membrane rearrangements, factories, and viroplasm produced during virus replication Virus factories, double membrane vesicles and viroplasm generated in animal cells Aggresomes and pericentriolar sites of virus assembly: Cellular defense or viral design? |
| cord-266985-9qwttt2y | Thus, in the case of NoV, it may be possible to simplify step 2 into assuming that p 2? 1 for those individuals who are genetically susceptible in having a functional FUT2 gene, while p 2= 0 for those who are genetically resistant through having a nonfunctional FUT2 gene. |
| cord-245161-xbw72k4m | Can N95 Respirators Be Reused after Disinfection? |
| cord-245161-xbw72k4m | How Many Times? |
| cord-245161-xbw72k4m | The iron- sulfur clusters of dehydratases are primary intracellular targets of copper toxicity Effects of temperature and humidity on the efficacy of methicillin- resistant Staphylococcus aureus challenged antimicrobial materials containing silver and copper Inactivation of murine norovirus on a range of copper alloy surfaces is accompanied by loss of capsid integrity Inactivation of norovirus on dry copper alloy surfaces Inactivation of influenza A virus on copper versus stainless steel surfaces Self- Disinfecting Copper Beds Sustain Terminal Cleaning and Disinfection Effects throughout Patient Care Photocatalytic disinfection using titanium dioxide: spectrum and mechanism of antimicrobial activity Understanding the antimicrobial mechanism of TiO₂-based nanocomposite films in a pathogenic bacterium Fabrication of Visible Light- Induced Antibacterial and Self- Cleaning Cotton Fabrics Using Manganese Doped TiO2 Nanoparticles Virus and Bacteria Self- Shielding System Self- disinfecting surfaces: review of current methodologies and future prospects Hygienic hand antiseptics: should they not have activity and label claims against viruses? |
| cord-245161-xbw72k4m | What determines the drop size in sprays? |
| cord-245161-xbw72k4m | you're out: how many swipes are needed to decontaminate plastic with disposable wipes? |
| cord-263017-rh86g4jk | and how do these vary amongst different strains and species; 2) What specific chemical modifications take place in the genome and capsid during disinfection and what effects do these modifications have on virus structure and function; 3) How similar are disinfectant- induced modifications amongst various enteric viruses? |
| cord-263017-rh86g4jk | how important are chloramine transfer reactions and protein tertiary structure? |
| cord-267326-355q6k6k | H7 carrying the Stx 2 gene in sewage from different countries Characterization of metagenomes in urban aquatic compartments reveals high prevalence of clinically relevant antibiotic resistance genes in wastewaters Variation of bacterial communities with water quality in an urban tropical catchment Unhealthy landscapes: policy recommendations on land use change and infectious disease emergence Disease emergence from global climate and land use change Agricultural intensification, priming for persistence and the emergence of Nipah virus: a lethal bat- borne zoonosis Gut DNA viromes of Malawian twins discordant for severe acute malnutrition Surveillance of enteric viruses and coliphages in a tropical urban catchment Obtaining genomes from uncultivated environmental microorganisms using FACS- based single- cell genomics Viral and microbial community dynamics in four aquatic environments Occurrence of Pepper Mild Mottle Virus( PMMoV) in Groundwater from a Karst Aquifer System in the Yucatan Peninsula VirSorter: mining viral signal from microbial genomic data Evolution and diversity of the Microviridae viral family through a collection of 81 new complete genomes assembled from virome reads Metavir 2: new tools for viral metagenome comparison and assembled virome analysis Evaluating the efficacy of commercial kits for viral DNA/ RNA extraction Metagenomic characterisation of the viral community of lough neagh, the largest freshwater lake in Ireland Eukaryotic viruses in wastewater samples from the United States Relationship of microbiota and cyanobacterial secondary metabolites in planktothricoides- dominated bloom Viral metagenomics on animals as a tool for the detection of zoonoses prior to human infection? |
| cord-267194-i6vetquk | is it and what is the host doing to clear it? |
| cord-269324-zh1a3gwh | Detrimental contribution of the Toll- like receptor( TLR)3 to influenza A virus- induced acute pneumonia Inhibition of retinoic acid- inducible gene I- mediated induction of beta interferon by the NS1 protein of influenza A virus Type 1 interferons and the virus- host relationship: a lesson in détente Homozygous deletion of the CYP21A- TNXA- RP2-C4B gene region conferring C4B deficiency associated with recurrent respiratory infections Association between mannose- binding lectin gene polymorphisms and susceptibility to severe acute respiratory syndrome coronavirus infection Association of SARS susceptibility with single nucleic acid polymorphisms of OAS1 and MxA genes: a case- control study Influenza vaccination as secondary prevention for cardiovascular disease: a science advisory from the American Heart Association/ American College of Cardiology MBL genotype and risk of invasive pneumococcal disease: a casecontrol study Genetic susceptibility to infectious diseases: big is beautiful, but will bigger be even better? |
| cord-263484-afcgqjwq | The value of patient self- report for disease surveillance Using internet search queries for infectious disease surveillance: screening diseases for suitability Using social media for actionable disease surveillance and outbreak management: a systematic literature review Social media as a sentinel for disease surveillance: what does sociodemographic status have to do with It? |
| cord-263484-afcgqjwq | Will Ebola change the game? |
| cord-266199-smlq11y9 | state- of- the- art Ten years of PCV2 vaccines and vaccination: is eradication a possibility? |
| cord-269975-1ebmq7t8 | Is in vitro antibiotic combination more effective than single- drug therapy against anthrax? |
| cord-268501-z4oztgi0 | , Clarisa B. title: What Would Jenner and Pasteur Have Done About COVID-19 Coronavirus? |
| cord-267567-w39f584z | Early dengue virus protein synthesis induces extensive rearrangement of the endoplasmic reticulum independent of the UPR and SREBP-2 pathway Bacterial membrane lipids: where do we stand? |
| cord-253466-7gpije5d | , 2004) induces vesicles and dispersal of the Golgi apparatus, which begs the questions, does this mutant use a different process for forming the replication complex, or do the mutations in 3A allow the proteins to compete with BFA for GBF1 recruitment? |
| cord-253466-7gpije5d | African swine fever virus is wrapped by the endoplasmic reticulum Cellular COPII proteins are involved in production of the vesicles that form the poliovirus replication complex Vaccinia virus membrane proteins p8 and p16 are cotranslationally inserted into the rough endoplasmic reticulum and retained in the intermediate compartment Daxx: Death or survival protein? |
| cord-253466-7gpije5d | Biogenesis from scratch? |
| cord-253466-7gpije5d | Hijacking components of the secretory pathway for replication of poliovirus RNA Does common architecture reveal a viral lineage spanning all three domains of life? |
| cord-253466-7gpije5d | Viral interactions with the cytoskeleton of mammalian cells Ultrastructure and origin of membrane vesicles associated with the severe acute respiratory syndrome coronavirus replication complex Assembly of vaccinia virus revisited: De novo membrane synthesis or acquisition from the host? |
| cord-266762-z08rn959 | A tale of 2 alpha- herpesviruses: lessons for vaccinologists Molecular and cellular insights into T cell exhaustion Coinhibitory pathways in immunotherapy for cancer Immunity and immunopathology to viruses: what decides the outcome? |
| cord-267733-fuz8r3vj | The world health organization and global smallpox eradication Vaccinia virus transcription Vaccinia virus vectors: New strategies for producing recombinant vaccines Poxvirus genome evolution by gene gain and loss Poxvirus cell entry: How many proteins does it take? |
| cord-268417-6eyetb5i | The latter possibility poses the question, Why, then, does it block the action of neutralizing antibody? |
| cord-022128-r8el8nqm | A unique intra- molecular fidelity- modulating mechanism identified in a viral RNA- dependent RNA polymerase Defective or effective? |
| cord-022128-r8el8nqm | Coxsackievirus B3 mutator strains are attenuated in vivo A single- nucleotide synonymous mutation in the gag gene controlling human immunodeficiency virus type 1 virion production Is sex necessary for the proliferation and transmission of Pneumocystis? |
| cord-022128-r8el8nqm | Linking RNA sequence, structure, and function on massively parallel highthroughput sequences Defective interfering influenza virus RNAs: time to reevaluate their clinical potential as broad- spectrum antivirals? |
| cord-022128-r8el8nqm | Pnemocystis genetic variability: cryptic biological species or clonal near- clades? |
| cord-022128-r8el8nqm | Quasispecies diversity determines pathogenesis through cooperative interactions in a viral population Replication slippage involves DNA polymerase pausing and dissociation Genome instability: a conserved mechanism of ageing? |
| cord-022128-r8el8nqm | Ribavirin resistance in hepatitis C virus replicon- containing cell lines conferred by changes in the cell line or mutations in the replicon RNA Altering the intracellular environment increases the frequency of tandem repeat deletion during Moloney murine leukemia virus reverse transcription Transfection- mediated generation of functionally competent Tula hantavirus with recombinant S RNA segment Low- fidelity polymerases of alphaviruses recombine at higher rates to overproduce defective interfering particles Mechanisms of retroviral mutation Reproductive clonality in protozoan pathogens ─ truth or artefact? |
| cord-022128-r8el8nqm | reveals the dynamic nature of viral genome evolution Molecular Basis of Virus Evolution Functional and genetic plasticities of the poliovirus genome: quasi- infectious RNAs modified in the 5'-untranslated region yield a variety of pseudorevertants Nonreplicative homologous RNA recombination: promiscuous joining of RNA pieces? |
| cord-264699-l8db5gll | Metabolic abnormalities and cardiovascular disease risk factors in adults with human immunodeficiency virus infection and lipodystrophy Metabolic complications associated with antiretroviral therapy Metabolic disorders among HIV- infected patients treated with protease inhibitors: a review HIV- associated lipodystrophy syndrome Human immunodeficiency virus type-1 accessory protein Vpr: a causative agent of the AIDS- related insulin resistance/ lipodystrophy syndrome? |
| cord-264699-l8db5gll | The hypothalamic- pituitary- adrenal axis and immune- mediated inflammation Effectiveness of prolonged glucocorticoid treatment in acute respiratory distress syndrome: the right drug, the right way? |
| cord-016808-gy8d8285 | , i.e., is there a single evolutionary tree or branch of viruses? |
| cord-016808-gy8d8285 | Do viruses form lineages across different domains of life? |
| cord-016808-gy8d8285 | Here a virus, there a virus, everywhere the same virus? |
| cord-016808-gy8d8285 | In other words, is there a place(s) for viruses on universal trees of life proposed for its three kingdoms, Archea, Eubacteria, and Eukarya? |
| cord-016808-gy8d8285 | Three RNA cells for ribosomal lineages and three DNA viruses to replicate their genomes: A hypothesis for the origin of cellular domain Origin of HIV-1 in the chimpanzee Pan troglodytes troglodytes Functional and genetic plasticities of the poliovirus genome: Quasi- infectious RNAs modified in the 5-untranslated region yield a variety of pseudorevertants Nonreplicative RNA recombination in poliovirus Nonreplicative homologous RNA recombination: Promiscuous joining of RNA pieces? |
| cord-016808-gy8d8285 | To what extent is the Muller's ratchet inevitable and irreversible? |
| cord-016808-gy8d8285 | What are relationships between viruses and cellular organisms? |
| cord-016808-gy8d8285 | What does then force them to evolve and to form new species and genera? |
| cord-016808-gy8d8285 | how does virus X remain virus X? |
| cord-016499-5iqpl23p | Antimicrobials for acute otitis media? |
| cord-016499-5iqpl23p | Do rhinoviruses reduce the probability of viral codetection during acute respiratory tract infections? |
| cord-016499-5iqpl23p | Human major group rhinoviruses downmodulate the accessory function of monocytes by inducing IL-10 Rhinovirus- induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production Interleukin-11: stimulation in vivo and in vitro by respiratory viruses and induction of airways hyperresponsiveness Nasal- secretion leukocyte populations determined by fl ow cytometry during acute rhinovirus infection Expression of intercellular adhesion molecule-1( ICAM-1) in nasal epithelial cells of atopic subjects: a mechanism for increased rhinovirus infection? |
| cord-016499-5iqpl23p | Infl uenza vaccination in the prevention of acute otitis media in children Effi cacy of a pneumococcal conjugate vaccine against acute otitis media Rhinovirus in acute otitis media Temporal relationships between colds, upper respiratory viruses detected by polymerase chain reaction, and otitis media in young children followed through a typical cold season Presence of viral nucleic acids in the middle ear: acute otitis media pathogen or bystander? |
| cord-016499-5iqpl23p | Is acute otitis media a treatable disease? |
| cord-016499-5iqpl23p | So, what do cohort studies, supported by comprehensive PCR- based testing, tell us about asymptomatic virus infections? |
| cord-016499-5iqpl23p | The cold case: Are rhinoviruses perfectly adapted pathogens? |
| cord-016499-5iqpl23p | The common cold: control? |
| cord-016499-5iqpl23p | The impact of dual viral infection in infants admitted to a pediatric intensive care unit associated with severe bronchiolitis Rhinovirus infections of children in hospital; isolation of three possibly new rhinovirus serotypes Do rhinoviruses reduce the probability of viral co- detection during acute respiratory tract infections? |
| cord-016499-5iqpl23p | This feature raises an issue: did the use of older subjects in many common cold studies underplay the pathogenic potential of the HRVs because protective or partially cross- protective antibodies moderated the impact of infection? |
| cord-016499-5iqpl23p | human rhinovirus type 17 Antigenic variation of rhinovirus type 22 Isolation of rhinovirus intertypes related to either rhinoviruses 12 and 78 or 36 and 58 Is a rhinovirus vaccine possible? |
| cord-018811-zhwr3h07 | But what then? |
| cord-018811-zhwr3h07 | But why did some die and exactly how were they killed by such a minute and fragile form of life that we know as the orthomyxovirus influenza? |
| cord-018811-zhwr3h07 | Could it be a Gram- negative bacterium such as H. influenzae, already described by Pfeiffer as the cause of the previous influenza pandemic of 1889? |
| cord-018811-zhwr3h07 | Gauguin in his last great painting"Who are we, where have we come from, where are we going?"asks crucial questions about the future of humankind. |
| cord-018811-zhwr3h07 | Or could it be a virus? |
| cord-018811-zhwr3h07 | These internally situated proteins are certainly immunogenic( particular NP) but could the immunity induced, either T cell or antibody, be broadly reacting? |
| cord-018811-zhwr3h07 | Twenty- First Century Vaccines Induce Protection Across the Different Virus Subtypes? |
| cord-018811-zhwr3h07 | Was the immune reaction and ensuing cytokine storm overwhelming or was virus replication in the endothelial cells of the air sacs more important? |
| cord-018811-zhwr3h07 | Why not create a reassortant in the laboratory with six replicative genes of A/ PR/8/34 to give high replication while having the two new HA and neuraminidase( NA) genes of the new epidemic virus? |
| cord-268788-jcu3pasy | The viruses and their replication Does IBV change slowly despite the capacity of the spike protein to vary greatly? |
| cord-260956-w6wxsg4p | Newcastle disease vaccines — A solved problem or a continuous challenge? |
| cord-260956-w6wxsg4p | Newcastle disease virus outbreaks: vaccine mismatch or inadequate application? |
| cord-260956-w6wxsg4p | vaccines represent the future? |
| cord-271927-u8p6c9w4 | What are some of the specific ways in which past pandemics were brought under control? |
| cord-268540-wrjzr3ws | ( COVID-19) Chloroquine is a potent inhibitor of SARS coronavirus infection and spread Synergistic antiviral effect of hydroxychloroquine and azithromycin in combination against SARS- CoV-2: what molecular dynamics studies of virus- host interactions reveal Deployment of convalescent plasma for the prevention and treatment of COVID-19 Plasma therapy against infectious pathogens, as of yesterday, today and tomorrow Meta- analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment? |
| cord-267671-ys43n672 | Veterinary Microbiology and Microbial Disease Uteroovarian infection in aged B6C3F1 mice Breast cancer: should gastrointestinal bacteria be on our radar screen? |
| cord-272405-jmwn8pdn | when and why? |
| cord-270647-vn4kirrx | Direct multiplexed whole genome sequencing of respiratory tract samples reveals full viral genomic information Human bocavirus infection as a cause of severe acute respiratory tract infection in children Metagenomic analysis of viral genetic diversity in respiratory samples from children with severe acute respiratory infection in China Metagenomic analysis of the respiratory virome associated with acute respiratory illness of unknown etiology in infants Is there still room for novel viral pathogens in pediatric respiratory tract infections? |
| cord-267003-k7eo2c26 | How do viral infections predispose patients to bacterial infections? |
| cord-267003-k7eo2c26 | a community- based birth cohort study Respiratory viral infections in adults Emerging respiratory agents: new viruses for old diseases? |
| cord-273343-als886fe | The canine distemper epidemic in Serengeti: are lions victims of a new highly virulent canine distemper virus strain, or is pathogen circulation stochasticity to blame? |
| cord-254100-u6x5zd4i | An umbraviral protein, involved in long- distance RNA movement, binds viral RNA and forms unique, protective ribonucleoprotein complexes Eukaryotic elongation factor 1A interacts with Turnip mosaic virus RNA- dependent RNA polymerase and VPg- Pro in virus- induced vesicles Regulation of host cell translation by viruses and effects on cell function Insights into nuclear organisation in plants as revealed by the dynamic distribution of Arabidopsis SR splicing factors Evolutionary origins of the RNA- guided nucleotide- modification complexes: from the primitive translation apparatus? |
| cord-254100-u6x5zd4i | The capsid protein of satellite panicum mosaic virus contributes to systemic invasion and interacts with its helper virus Getting the message across: How do plant cells exchange macromolecular complexes? |
| cord-254100-u6x5zd4i | The nucleolus-a gateway to viral infection? |
| cord-254100-u6x5zd4i | What's new in the nucleolus? |
| cord-254100-u6x5zd4i | viroid RNA in vitro and in vivo Pumpimg RNA: Nuclear bodybuilding along the RNP pipeline Nuclear bodies: random aggregates of sticky proteins or crucibles of macromolecular assembly? |
| cord-254527-zddwajzg | An improved manufacturing process for Xyntha/ ReFacto AF Evaluation of the virus clearance capacity and robustness of the manufacturing process for the recombinant factor VIII protein, turoctocog alfa Alternative affinity ligands for immunoglobulins Protein A chromatography for antibody purification Trends in upstream and downstream process development for antibody manufacturing The role of more than 40 years of improvement in protein A chromatography in the growth of the therapeutic antibody industry Quality by design approach for viral clearance by protein A chromatography Identification of protein A media performance attributes that can be monitored as surrogates for retrovirus clearance during extended reuse Robustness of virus removal by protein A chromatography is independent of media lifetime Clearance of the rodent retrovirus, XMuLV, by protein A chromatography Virus elimination during the purification of monoclonal antibodies by column chromatography and additional steps Many factor VIII products available in the treatment of hemophilia A: an embarrassment of riches? |
| cord-254527-zddwajzg | Pathogen inactivation and removal methods for plasma- derived clotting factor concentrates A review of the invasive mosquitoes in Europe: ecology, public health risks, and control options Viral vaccines and their manufacturing cell substrates: new trends and designs in modern vaccinology Vaccination against dengue: challenges and current developments Ebola virus vaccines: where do we stand? |
| cord-254527-zddwajzg | Production of recombinant coagulation factors: Are humans the best host cells? |
| cord-254527-zddwajzg | Recent developments in chromatographic purification of biopharmaceuticals Evolving trends in mAb production processes Affinity chromatography for vaccines manufacturing: finally ready for prime time? |
| cord-254527-zddwajzg | What perspectives for PS- based chromatography materials in this background of technological development? |
| cord-255734-038xu4hq | Can the virus establish persistent infection and can humans be repeatedly infected? |
| cord-255734-038xu4hq | Finally, if SARS fails to return, how will vaccine manufacturers test candidate vaccines for efficacy? |
| cord-255734-038xu4hq | If we define the ability of the virus to replicate in monocytes/ macrophages can we be assured that antibody- dependent enhancement will not be a problem for a SARS vaccine? |
| cord-255734-038xu4hq | What are the viral virulence factors and can we use this information to develop an attenuated strain? |
| cord-255734-038xu4hq | What is the role of lymphocytic infiltrates and do alveolar macrophages enhance disease or control infection? |
| cord-271709-5frm3dnb | Do rhinoviruses reduce the probability of viral co- detection during acute respiratory tract infections? |
| cord-271709-5frm3dnb | Rhinoviruses delayed the circulation of the pandemic influenza A( H1N1) 2009 virus in France Does viral interference affect spread of influenza? |
| cord-263619-p17oomzn | IL-10 during measles in Zambian children Atypical exanthem following exposure to natural measles: eleven cases in children previously inoculated with killed vaccine Communicating science to the public: MMR vaccine and autism Measles eradication: is it in our future? |
| cord-263619-p17oomzn | The development of a plant- based vaccine for measles Effect of subclinical infection on maintaining immunity against measles in vaccinated children in West Africa Has the 2005 measles mortality reduction goal been achieved? |
| cord-263619-p17oomzn | The effect of dose and strain of live attenuated measles vaccines on serological responses in young infants Can measles be eradicated globally? |
| cord-271171-tohbzenc | The SARS, MERS and novel coronavirus( COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? |
| cord-271171-tohbzenc | What if the virus mutation occurs causing re- infection( Figure 2) or what if there comes a second wave of infection affecting large numbers? |
| cord-269126-d81z6t0a | Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection? |
| cord-269126-d81z6t0a | Why calcium channel blockers? |
| cord-269426-82g5eiyg | A replication- incompetent adenovirus vector with the preterminal protein gene deleted efficiently transduces mouse ears Nucleotide sequencing and generation of an infectious clone of adeno- associated virus 3 Live- attenuated HIV vaccines: how safe is safe enough? |
| cord-273372-69rlh9or | And yet we began to wonder, why has there been relatively little focus on small molecules apart from a recent review of Ebola virus therapeutic strategies in general 9? |
| cord-271105-eyigl0wz | How long do nosocomial pathogens persist on inanimate surfaces? |
| cord-271105-eyigl0wz | Some principles of virucidal testing Hygienic hand antiseptics: should they not have activity and label claims against viruses? |
| cord-270772-zshjrc87 | An integration of in vitro, animal and clinical data will allow researchers 12 Engineering for viral resistance Papers of particular interest, published within the period of review, have been highlighted as: of special interest of outstanding interest World Health Organization: Influenza( seasonal) Estimated global mortality associated with the first 12 months of 2009 pandemic influenza A H1N1 virus circulation: a modelling study Two years after pandemic influenza A/2009/ H1N1: what have we learned? |
| cord-270772-zshjrc87 | Emergence in China of human disease due to avian influenza A(H10N8)-cause for concern? |
| cord-255096-27dfbhsl | , protozoan parasites of molluscs, through 2D electrophoresis and mass spectrometry Range extension by the oyster parasite Perkinsus marinus into the northeastern United States: response to climate change? |
| cord-255096-27dfbhsl | A boom- bust phylum? |
| cord-255096-27dfbhsl | Epidemiological studies on the explosive epidemic disease of prawn in 1993- 1994 Diseases of spiny lobsters: a review Common disease: are causative alleles common or rare? |
| cord-255096-27dfbhsl | The elusive baseline of marine disease: are diseases in ocean ecosystems increasing? |
| cord-255096-27dfbhsl | The order herpesvirales Early mortality syndrome outbreaks: a microbial management issue in shrimp farming? |
| cord-270161-vaejyy4i | The naïve boar stud PRRS dilemma e prevention, detection or both? |
| cord-270161-vaejyy4i | will oral fluid replace serum for PRRS surveillance? |
| cord-272981-8gahvdt0 | All animals tested except? |
| cord-023143-fcno330z | *? |
| cord-023143-fcno330z | , Cara Wilsont, Kelledy Mansons, Michael Wyands, Bruce Walker?, Ronald C. Desrosiers |
| cord-023143-fcno330z | However, productive virus replication is minimized by antiviral CD8 T cells which suppress( kill?) |
| cord-023143-fcno330z | PrP genes were used to demonstrate that the"specie9 bank?' |
| cord-023143-fcno330z | The interferons( IFNs) a n? a family of cytokines whose functions include the protection of cells against viral infection. |
| cord-023143-fcno330z | Thes? |
| cord-023143-fcno330z | ofthe influenza HA protein from this second promoter in baby hamster kidney( BHK) cells was approximately 50?? |
| cord-023143-fcno330z | ofthe influenza HA protein from this second promoter in baby hamster kidney( BHK) cells was approximately 50?? |
| cord-268645-5op2m7pu | Hendra and Nipah viruses: why are they so deadly? |
| cord-268645-5op2m7pu | The SARS coronavirus: a postgenomic era Global trends in emerging infectious diseases Identification and complete genome analysis of three novel paramyxoviruses, Tuhoko virus 1, 2 and 3, in fruit bats from China Fruit bats as reservoirs of Ebola virus Bat guano virome: predominance of dietary viruses from insects and plants plus novel mammalian viruses Circovirus in tissues of dogs with vasculitis and hemorrhage Bats are natural reservoirs of SARS- like coronaviruses Prevalence and genetic diversity of adenoassociated viruses in bats from China Epidemic dynamics at the human- animal interface A comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special? |
| cord-274112-6t0wpiqy | A pandemic warning? |
| cord-014462-11ggaqf1 | Both ATP and GTP were utilized as phosporyl donors and Mn 2? |
| cord-014462-11ggaqf1 | Cut off was calculated as Mean negative control? |
| cord-014462-11ggaqf1 | FMDV P1- 3CD''O''vaccine gene constructs in pCDNA3.1? entrapped by the nanoparticles was prepared by using different molarity of calcium chloride and disodium hydrogen orthophosphate. |
| cord-014462-11ggaqf1 | Helicase activity of NSs was absolutely dependent on ATP and Mg 2? |
| cord-014462-11ggaqf1 | How do Indian journals perform in Maintaining quality? |
| cord-014462-11ggaqf1 | How do motivate the scientists to improve their scientific output? |
| cord-014462-11ggaqf1 | How to motivate the scientists to improve their scientific output? |
| cord-014462-11ggaqf1 | In this regard, rNSs is a unique enzyme which does not have the canonical helicase motifs but can catalyze dsDNA/ dsRNA unwinding in an ATP and Mg 2? |
| cord-014462-11ggaqf1 | Should we compare the growth of Indian science with other developed countries? |
| cord-014462-11ggaqf1 | What ails Indian Science? |
| cord-014462-11ggaqf1 | What criteria should be adopted to judge the quality and standard of scientific research? |
| cord-006252-cbelsymu | Are the side effects a frequent concern? |
| cord-006252-cbelsymu | Are the side effects a frequent concern? |
| cord-006252-cbelsymu | But why is influenza a problem year after year? |
| cord-006252-cbelsymu | But why is influenza a problem year after year? |
| cord-006252-cbelsymu | How effective is influenza vaccine? |
| cord-006252-cbelsymu | How effective is influenza vaccine? |
| cord-006252-cbelsymu | Is it easy to diagnose? |
| cord-006252-cbelsymu | Is it easy to diagnose? |
| cord-006252-cbelsymu | What efforts have been and can be made to improve vaccine acceptance? |
| cord-006252-cbelsymu | What efforts have been and can be made to improve vaccine acceptance? |
| cord-006252-cbelsymu | What is influenza? |
| cord-006252-cbelsymu | What is influenza? |
| cord-006252-cbelsymu | Why the difference? |
| cord-006252-cbelsymu | Why the difference? |
| cord-104317-t30dg6oj | : next- generation sequencing applied to phage populations in the human gut GB Virus C/ Hepatitis G Virus Infection: A Favorable Prognostic Factor in Human Immunodeficiency Virus- Infected Patients? |
| cord-104317-t30dg6oj | Culture An inquiry into the causes and effects of the variolae vaccinae, a disease discovered in some of the western counties of England, particularly Gloucestershire, and known by the name of the cow pox Coevolution of hosts and parasites Vertical transmission of viruses What is a quasispecies? |
| cord-104317-t30dg6oj | Phage Therapy in the Food Industry Complete nucleotide sequences of four dsRNAs associated with a new chrysovirus infecting Aspergillus fumigatus Mycoviruses: future therapeutic agents of invasive fungal infections in humans? |
| cord-104317-t30dg6oj | Positional cloning of the mouse retrovirus restriction gene Fv1 Rmcf2, a xenotropic provirus in the Asian mouse species Mus castaneus, blocks infection by polytropic mouse gammaretroviruses From ancestral infectious retroviruses to bona fide cellular genes: Role of the captured syncytins in placentation Retroviruses and the Placenta Retroviral gene therapy: safety issues and possible solutions Decade- Long Safety and Function of Retroviral- Modified Chimeric Antigen Receptor T Cells Bacteriophage adhering to mucus provide a non- host- derived immunity Reinventing phage therapy: are the parts greater than the sum? |
| cord-104317-t30dg6oj | Public Health and Medical Uncertainty Current and emerging infectious risks of blood transfusions AIDS pathogenesis: what have two decades of HIV research taught us? |
| cord-104317-t30dg6oj | While the virus has a safe home during persistence, the question arises that if a virus is not replicating, or is present at very low levels, how is it transmitted to the next host? |
| cord-027550-yyqsatqw | : Predicting asthma following RSV- positive bronchiolitis in early childhood Viral lower respiratory tract infections and preterm infants'healthcare utilisation Respiratory syncytial virus infection and chronic respiratory morbidity-is there a functional or genetic predisposition? |
| cord-027550-yyqsatqw | : Where are we? |
| cord-027550-yyqsatqw | Are we missing respiratory viral infections in infants and children? |
| cord-027550-yyqsatqw | Burden of RSV disease in Europe Are we missing respiratory viral infections in infants and children? |
| cord-027550-yyqsatqw | Is radiological appearance of lower respiratory tract infection due to respiratory syncytial virus a predictor of clinical outcome? |
| cord-027550-yyqsatqw | What is new with the vaccines? |
| cord-027550-yyqsatqw | What is precision medicine? |
| cord-027550-yyqsatqw | can we distinguish Respiratory Viral Infections based on clinical Symptoms? |
| cord-267134-5gz2dotn | Could BCG vaccination induce protective trained immunity for SARS- CoV-2? |
| cord-267134-5gz2dotn | Host signaling and proteolytic pathways in the resolution or the exacerbation of coronavirus( CoV-2) infection in COVID-19 disease: what therapeutic targets? |
| cord-267134-5gz2dotn | Innate Immune Signaling and Proteolytic Pathways in the Resolution or Exacerbation of SARS- CoV-2 in Covid-19: Key Therapeutic Targets? |
| cord-273708-2q64at3z | May Polyphenols Have a Role Against Coronavirus Infection? |
| cord-276212-ys5njiw0 | NL63 infection and other coronavirus infections in children hospitalized with acute respiratory disease in Hong Kong Are meteorological parameters associated with acute respiratory tract infections? |
| cord-258626-p469ysi8 | ( although a specific disease may not commonly be seen, the organism is ubiquitous in the environment and therefore poses risk to the individual or population);( 3) the risk of the individual for exposure to the disease( indoor- only animal vs free- roaming individual, regional variations of occurrence);( 4) the efficacy of the vaccine( does the vaccine prevent infection or simply ameliorate some signs or length of disease?);( 5) the risks associated with administering the vaccine( are the risks associated with that vaccine greater than the risk of the disease?);( 6) the potential for zoonotic disease;( 7) the route of infection or transmissibility. |
| cord-258626-p469ysi8 | ( although a specific disease may not commonly be seen, the organism is ubiquitous in the environment and therefore poses risk to the individual or population);( 3) the risk of the individual for exposure to the disease( indoor- only animal vs free- roaming individual, regional variations of occurrence);( 4) the efficacy of the vaccine( does the vaccine prevent infection or simply ameliorate some signs or length of disease?);( 5) the risks associated with administering the vaccine( are the risks associated with that vaccine greater than the risk of the disease?);( 6) the potential for zoonotic disease;( 7) the route of infection or transmissibility. |
| cord-258626-p469ysi8 | Criteria for assigning vaccines into these categories, and a third category,"generally not recommended,"are based on:( 1) morbidity and mortality associated with the specific disease( does the organism cause serious illness or does it cause a mild, transient disease that may pose only minimal risk to the individual or population?); |
| cord-258626-p469ysi8 | If an owner brings a Labrador retriever puppy to the veterinarian for"whatever vaccines he needs,"it is up to the practitioner to ask"will he be a hunting dog, will he be used in field trials, will he be exposed to wildlife and waterways?" |
| cord-258626-p469ysi8 | Who better to disseminate knowledge about veterinary medicine to the general public than veterinarians? |
| cord-023724-5at0rhqk | ( Long- term) pathogenic consequences? |
| cord-023724-5at0rhqk | A high proportion of the human population has already been vaccinated- lifelong protection may result in poor response to recombinant vaccines(?). |
| cord-023724-5at0rhqk | Difficult to grow to high titer and purify for direct administration( patient cells must be cultured in vitro); can not infect nondividing cells- most somatic cells( except lentiviruses?); insertional mutagenesis/ activation of cellular oncogenes. |
| cord-023724-5at0rhqk | How do CRISPRs work? |
| cord-023724-5at0rhqk | How do plant viruses induce disease? |
| cord-023724-5at0rhqk | How do viruses avoid inhibition by endogenous cellular microRNAs? |
| cord-023724-5at0rhqk | Integrate into cell genome, giving long- lasting( lifelong?) |
| cord-023724-5at0rhqk | So how do bacteria survive against this constant onslaught? |
| cord-023724-5at0rhqk | So who( apart from bacteria) cares about CRISPRs? |
| cord-276348-vr5fit8r | Is RSV disease a true consequence of all these different pathogenic mechanisms proposed, or are they set in motion as a result of the activation of different immunoregulatory pathways during the replication of the virus in the mucosa? |
| cord-260472-xvvfguht | George N. title: Antimicrobial strategies: An option to treat allergy? |
| cord-260472-xvvfguht | Rhinovirus- induced interferon- gamma and airway responsiveness in asthma Antigen- nonspecific recruitment of Th2 cells to the lung as a mechanism for viral infection- induced allergic asthma Personal exposure to nitrogen dioxide( NO2) and the severity of virus- induced asthma in children Epidemiology of childhood asthma Are non- allergenic environmental factors important in asthma? |
| cord-260472-xvvfguht | The development of asthma in children infected with Chlamydia pneumoniae is dependent on the modifying effect of mannose- binding lectin The effect of telithromycin in acute exacerbations of asthma Vaccines, vaccination, and vaccinology Prophylaxis with palivizumab against respiratory syncytial virus infection in infants with congenital heart diseasedwho should receive it? |
| cord-260472-xvvfguht | The incidence of respiratory tract infection in adults requiring hospitalization for asthma Epidemiology of respiratory viruses in patients hospitalized with near- fatal asthma, acute exacerbations of asthma, or chronic obstructive pulmonary disease Is asthma an infectious disease?: |
| cord-260472-xvvfguht | Thomas A. Neff lecture Chlamydophila pneumoniae and Mycoplasma pneumoniae: a role in asthma pathogenesis? |
| cord-270670-cubh9jxc | A principle of natural self- organization Genetic lesions associated with Muller's ratchet in an RNA virus Molecular biology, pathogenesis, and control of animal viruses Lethal mutagens: broad- spectrum antivirals with limited potential for development of resistance? |
| cord-270670-cubh9jxc | Can studies on complexity be of use to infectious diseases? |
| cord-276052-gk6n8slx | to detect novel paramyxoviruses Bats and viruses: friend or foe? |
| cord-276583-j8bf0eme | Molecular evolutionary genetics analysis software- version 4.0 Avian influenza virus monitoring in wintering waterbirds in Iran Fields virology, vols 1 and 2 Glycosylation requirements for intracellular transport and function of the hemagglutinin of influenza virus Genetic analysis of hemagglutinin protein of H9N2 isolated from live bird markets in Tehran Province in Molecular characterization of H9N2 influenza viruses: were they the donors of the"internal"genes of H5N1 viruses in Hong Kong? |
| cord-277107-gs7j6fxo | a narrative review Current scenario of HIV/ AIDS, treatment options, and major challenges with compliance to antiretroviral therapy From where did the 2009'swine- origin'influenza A virus( H1N1) emerge? |
| cord-266136-81sx505i | Ou alors l'épidémie à hMPV qui coïncide fréquemment avec celle due au hRSV jouet- elle un rôle? |
| cord-266136-81sx505i | dans la population entre les épidémies? |
| cord-266136-81sx505i | de vie des nourrissons liée notamment à la fréquentation précoce des collectivités d'enfants et des lieux publics, ou des 2? |
| cord-266136-81sx505i | pédiatriques ou hospitalisés pour une BA par rapport à l'ensemble des enfants atteints? |
| cord-264916-c4n0kyog | The severe acute respiratory syndrome coronavirus in tears Tears and conjunctival scrapings for coronavirus in patients with SARS Ocular screening in severe acute respiratory syndrome SARS virus in tears? |
| cord-264916-c4n0kyog | Therefore, a question arises: if the receptors for the virus are present in ocular surface tissues, why the incidence of ocular surface infection is so low and isolating the virus from ocular surfaces presents such a challenge? |
| cord-264916-c4n0kyog | Would a rose by another name smell as sweet? |
| cord-264916-c4n0kyog | breath condensate pH in adult Croatian population without respiratory disorders: how healthy a population should be to provide normative data? |
| cord-256615-gvq8uyfk | How can we be better prepared to identify emerging pathogens early? |
| cord-256615-gvq8uyfk | How many pathogenic viruses remain to be discovered? |
| cord-256615-gvq8uyfk | Is it feasible to predict which animal viruses have the potential to cause disease in humans? |
| cord-256615-gvq8uyfk | The global distribution and burden of dengue Airborne transmission of influenza A/ H5N1 virus between ferrets Role of receptor binding specificity in influenza A virus transmission and pathogenesis Venezuelan equine encephalitis emergence: enhanced vector infection from a single amino acid substitution in the envelope glycoprotein Chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come? |
| cord-256615-gvq8uyfk | The human virome: new tools and concepts Human polyomaviruses in disease and cancer Bats and their virome: an important source of emerging viruses capable of infecting humans Overviews of pathogen emergence: which pathogens emerge, when and why? |
| cord-256615-gvq8uyfk | What is the best strategy for identifying and limiting the menace from novel, zoonotic viruses? |
| cord-276039-nqqwnmwc | The recent discovery of endogenous viruses, and FV in fishes Overviews of pathogen emergence: which pathogens emerge, when and why? |
| cord-272052-8vvpm4tx | A feline leukaemia virus- and sarcoma virus- induced tumourspecific antigen Retrospective study of 46 cases of feline haemobartonellosis in Israel and their relationships with FeLV and FIV infections Feline leukemia virus-most important oncogene in cats? |
| cord-272052-8vvpm4tx | Exogenous glucocorticoids alter parameters of early feline immunodeficiency virus infection Feline immunodeficiency virus integration in B- cell lymphoma identifies a candidate tumor suppressor gene on human chromosome 15q15 Molecular and immunophenotypical characterization of a feline immunodeficiency virus( FIV)-associated lymphoma: a direct role for FIV in B- lymphocyte transformation? |
| cord-272052-8vvpm4tx | Molecular analysis of tumours from feline immunodeficiency virus( FIV)-infected cats: an indirect role for FIV? |
| cord-275602-cog4nma0 | Why Indian? |
| cord-275602-cog4nma0 | why NDM-1? |
| cord-276364-zyw5aukk | deranges dengue virion maturation Knockdown of autophagy enhances the innate immune response in hepatitis C virus- infected hepatocytes Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro Cholesterol manipulation by West Nile virus perturbs the cellular immune response Perturbation of intracellular cholesterol and fatty acid homeostasis during flavivirus infections Autophagy in cell death: an innocent convict? |
| cord-276506-dj7dyo0x | The technical assistance of? |
| cord-270940-acwkh6ed | Have changes taken place in the viruses themselves? |
| cord-270940-acwkh6ed | Molecular evolution and distribution of dengue viruses type 1 and 2 in nature Epidemiology and clinical features of imported dengue fever in Europe: sentinel surveillance data from TropNetEurop Origins, evolution, and vector/ host coadaptations within the genus Flavivirus Diagnosis of tick- borne encephalitis West Nile virus: a growing concern? |
| cord-270940-acwkh6ed | What are the reasons for the appearance of all these emerging and re- emerging viruses? |
| cord-252871-qfrpuy3t | : do we need a fourth domain of life to explain the origin of eukaryotes? |
| cord-252871-qfrpuy3t | Can protein structure- based methods improve the evolutionary studies of viruses? |
| cord-252871-qfrpuy3t | Do well defined boundaries exist between cellular and viral lineages? |
| cord-252871-qfrpuy3t | How are RNA and DNA viruses evolutionarily related? |
| cord-252871-qfrpuy3t | How do we explain the origin and abundance of virus- specific genes in viral genomes? |
| cord-252871-qfrpuy3t | How to visualize and illustrate viruses( virus factories) if virions can not and should not be used to describe viruses? |
| cord-252871-qfrpuy3t | The path from the RNA world Three RNA cells for ribosomal lineages and three DNA viruses to replicate their genomes: A hypothesis for the origin of cellular domain Mimivirus: The emerging paradox of quasi- autonomous viruses Phylogenetic tree building in the genomic age Benefits of using molecular structure and abundance in phylogenomic analysis Can sequence phylogenies safely infer the origin of the global virome? |
| cord-252871-qfrpuy3t | Viral eukaryogenesis: was the ancestor of the nucleus a complex DNA virus? |
| cord-266822-ecq50ye2 | Has estimation of numbers of cases of pandemic influenza H1N1 in England in 2009 provided a useful measure of the occurrence of disease? |
| cord-266822-ecq50ye2 | Success factors of European syndromic surveillance systems: a worked example of applying qualitative comparative analysis Innovative digital tools and surveillance systems for the timely detection of adverse events at the point of care: a proof- of- concept study Enabling precision medicine with digital case classification at the point- of- care Can mobile technologies improve on- time vaccination? |
| cord-266822-ecq50ye2 | Supplementary Data) Case- control study of clinical features of influenza in hospitalized patients Is influenza an influenza- like illness? |
| cord-266822-ecq50ye2 | What is the clinical relevance of respiratory syncytial virus bronchiolitis?: |
| cord-273326-gmw8gl2r | The crystal structure of Zika virus NS5 reveals conserved drug targets Antibody- dependent enhancement and zika: Real threat or phantom menace? |
| cord-273326-gmw8gl2r | Zika virus infection damages the testes in mice Zika virus infection of rhesus macaques leads to viral persistence in multiple tissues Zika virus: What have we learnt since the start of the recent epidemic? |
| cord-278465-tjjkz16y | molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods Individual variation in influenza A virus infection histories and longterm immune responses in mallards Prevalence of avian paramyxovirus type 1 in Mallards during autumn migration in the western Baltic Sea region Unleashing the Potential of Urban Growth Minor differences in body condition and immune status between avian influenza virus- infected and noninfected mallards: a sign of coevolution? |
| cord-279798-b5tduubu | Quantitative real- time PCR of enteric viruses in influent and effluent samples from wastewater treatment plants in Italy Monitoring and evaluation of infectious rotaviruses in various wastewater effluents and receiving waters revealed correlation and seasonal pattern of occurrences Detection and typing of norovirus from frozen strawberries involved in a large- scale gastroenteritis outbreak in Germany Quantifying health risks in wastewater irrigation Virtual groundwater transfers from overexploited aquifers in the United States Predictive microbiology theory and application: is it all about rates? |
| cord-276193-cngz535o | A pandemic warning? |
| cord-276193-cngz535o | improves the immunogenicity of modified vaccinia virus Ankara expressing HIV-1 antigens Designing cell lines for viral vaccine production: where do we stand? |
| cord-278973-82n0d1dh | : can we confidently link bats with emerging deadly viruses? |
| cord-276715-d1nh2dvb | Is low copper status immunosuppressive? |
| cord-276715-d1nh2dvb | authors: Raha, Syamal; Mallick, Rahul; Basak, Sanjay; Duttaroy, Asim K. title: Is Copper beneficial for COVID-19 patients? |
| cord-280048-b4dz1lnn | How could the problem we approached? |
| cord-279557-hk77e3pp | A simple, fast, and accurate algorithm to estimate large phylogenies by maximum likelihood Family cluster of Middle East Respiratory Syndrome coronavirus infections Detection of herpes simplex virus DNA by real- time PCR Real- time reverse transcription- PCR assay for comprehensive detection of human rhinoviruses Respiratory herpes simplex virus type 1 infection/ colonisation in the critically ill: marker or mediator? |
| cord-278511-je1509ar | How can this be addressed? |
| cord-274080-884x48on | Molecular mechanism of divalentmetal- induced activation of NS3 helicase and insights into Zika virus inhibitor design HCV infection by cell- to- cell transmission: choice or necessity? |
| cord-274080-884x48on | Novel ESCRT functions in cell biology: spiraling out of control? |
| cord-259233-smmhhroe | Cold Spring Harbor Perspectives in Late budding domains and host proteins in enveloped virus release Mechanisms for enveloped virus budding: can some viruses do without an ESCRT? |
| cord-259233-smmhhroe | Could CD4 capture by CD8+ T cells play a role in HIV spreading? |
| cord-259233-smmhhroe | Exosomes and retroviruses: the chicken or the egg? |
| cord-259233-smmhhroe | Herpesviruses remodel host membranes for virus egress Human immunodeficiency virus-1 inhibition of immunoamphisomes in dendritic cells impairs early innate and adaptive immune responses ORF1a- encoded replicase subunits are involved in the membrane association of the arterivirus replication complex Kunjin virus: an Australian variant of West Nile? |
| cord-259233-smmhhroe | Trojan exosomes riding the Trojan horse? |
| cord-259233-smmhhroe | Virus assembly and plasma membrane domains: which came first? |
| cord-259233-smmhhroe | and what is its purpose? |
| cord-030279-pv770doe | Accidents involving dangerous pathogens such as the causative agents of anthrax and bird flu were reported Biosafety in the Balance'Anthrax? |
| cord-030279-pv770doe | Are we sufficiently resilient to cope with the emotional distress, anxiety, shame, stigma and guilt that the awareness of severe medical conditions that we or our closed ones are suffering or likely to develop? |
| cord-030279-pv770doe | Extending Responsible Research and Innovation in Synthetic Biology to New Actors, Research Report for the Wellcome Trust Project'Building Sustainable Capacity in Dual Use Bioethics Secret Project Manufactured Mock Anthrax', The Washington Times Biological Weapons and America's Secret War Global Governance and the Twenty- First Century Technology Converging technologies for Improving Human Performance: Nanotechnology, Biotechnology, Information technology and Cognitive Science Report of the WHO Informal Consultation on Dual Use Research of Concern Biological Threat Assessment: Is the Cure Worse than the Disease? |
| cord-030279-pv770doe | How to account for this discrepancy? |
| cord-030279-pv770doe | Nature News Anthrax letters'attack and the controversy of the US biodefence programme see Jeanne Guillemin Army Suspends Germ Research at Maryland Lab Back to Bioweapons? |
| cord-030279-pv770doe | On the framing of risk in biotechnology, see Geert van Calster,'Risk Regulation, EU Law and Emerging Technologies: Smother or Smooth? |
| cord-030279-pv770doe | Panacea or Pandora's Box?', News Release On the security implications of synthetic biology, see International Council for the Life Sciences Synthetic Biology and Biosecurity Awareness in Europe |
| cord-030279-pv770doe | The Achilles'Helix From Eugenics to Patents Three- Person"Embryos to Combat Genetic Disease', The Guardian Innovative Genetic Treatment to Prevent Mitochondrial Disease, Press Release Three- Parent Embryos for Mitochondrial Disease? |
| cord-030279-pv770doe | Use of Gas against Terrorists during the Moscow Theatre Siege Was Justified, but the Rescue Operation afterwards Was Poorly Planned and Implemented Spasenie zalozhnikov ili unichtozhenie terroristov?', Novaya Gazeta |
| cord-267261-8z4aqfff | Avian influenza A virus( H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome Transmission of H7N7 avian influenza A virus to human beings during a large outbreak in commercial poultry farms in the Netherlands Additional glycosylation at the receptor binding site of the hemagglutinin( HA) for H5 and H7 viruses may be an adaptation to poultry hosts, but does it influence pathogenicity? |
| cord-267261-8z4aqfff | Characterization of H9 subtype influenza viruses from the ducks of southern China: a candidate for the next influenza pandemic in humans? |
| cord-267261-8z4aqfff | H3N2 influenza A viruses in pigs in southeastern China: potential for genetic reassortment? |
| cord-267261-8z4aqfff | Nipah virus- a potential agent of bioterrorism? |
| cord-279691-v5kpmk0b | How are the nsps of CoVs able to induce the observed membrane rearrangements? |
| cord-282344-o1rkx2z4 | How contagious are common respiratory tract infections? |
| cord-271122-3fsl5589 | What is stress, and how does it affect reproduction? |
| cord-271122-3fsl5589 | Why is it getting more difficult to successfully artificially inseminate dairy cows? |
| cord-271122-3fsl5589 | how soon does the cow know she is pregnant? |
| cord-276585-m1dkkbq7 | : West Nile virus spread to Galapagos Quantitative risk assessment of the pathways by which West Nile virus could reach Hawaii Processive proofreading by the adenovirus DNA polymerase- association with the priming protein reduces exonucleolytic degradation Hybridization as a source of variation for adaptation to new environments Structure of SARS coronavirus spike receptor- binding domain complexed with receptor Infectious disease dynamics: what characterizes a successful invader? |
| cord-276585-m1dkkbq7 | : what are the relative roles of ecology and evolution? |
| cord-276585-m1dkkbq7 | The origins of acquired immune deficiency syndrome viruses: where and when? |
| cord-281429-6lv3di4x | Shedding of Japanese encephalitis virus in oral fluid of infected swine North American domestic pigs are susceptible to experimental infection with Japanese encephalitis virus Japanese encephalitis virus tropism in experimentally infected pigs How much does direct transmission between pigs contribute to Japanese encephalitis virus circulation? |
| cord-278635-vwdxr1bl | A defective interfering influenza RNA inhibits infectious influenza virus replication in human respiratory tract cells: a potential new human antiviral Cell culture- based production of defective interfering particles for influenza antiviral therapy Influenza virus DI particles: Defective interfering or delightfully interesting? |
| cord-278635-vwdxr1bl | The defective component of viral populations Incomplete forms of influenza virus Functional characterization of naturally occurring variants of human hepatitis B virus containing the core internal deletion mutation Defective interfering viral particles in acute dengue infections Internally deleted WNV genomes isolated from exotic birds in New Mexico: function in cells, mosquitoes, and mice SMRT sequencing revealed the diversity and characteristics of defective interfering RNAs in influenza A( H7N9) virus infection Influenza defective interfering viral RNA is formed by internal deletion of genomic RNA Segment- specific noncoding sequences of the influenza virus genome RNA are involved in the specific competition between defective interfering RNA and its progenitor RNA segment at the virion assembly step Defective interfering influenza virus RNAs: time to reevaluate their clinical potential as broad- spectrum antivirals? |
| cord-264408-vk4lt83x | ( l- sIGN) is a receptor for severe acute respiratory syndrome coronavirus Glycomic characterization of respiratory tract tissues of ferrets: implications for its use in influenza virus infection studies Comparative analysis of monkeypox virus infection of cynomolgus macaques by the intravenous or intrabronchial inoculation route Phenotypic changes in langerhans'cells after infection with arboviruses: a role in the immune response to epidermally acquired viral infection? |
| cord-264408-vk4lt83x | A novel model of lethal Hendra virus infection in African green monkeys and the effectiveness of ribavirin treatment Clinical outcome of henipavirus infection in hamsters is determined by the route and dose of infection recent progress in henipavirus research: molecular biology, genetic diversity, animal models Mucosal arenavirus infection of primates can protect them from lethal hemorrhagic fever sArs vaccines: where are we? |
| cord-264408-vk4lt83x | A simple technique for infection of mosquitoes with viruses; transmission of Zika virus Human papillomavirus research: do we still need animal models? |
| cord-264408-vk4lt83x | An unusual hantavirus outbreak in southern Argentina: person- to- person transmission? |
| cord-264408-vk4lt83x | emerg sArs: what have we learned? |
| cord-285148-bch7814v | Up- regulation of interferonstimulated genes If interferon production in response to virus infection is impaired in asthmatics what are the possible molecular mechanisms underlying this? |
| cord-278913-u6vihq3u | What Caused the Black Death? |
| cord-278913-u6vihq3u | and How will they Impact Health Care? |
| cord-290034-4b0mshqa | Should New Antiviral Therapies and Vaccines Be Adopted? |
| cord-270091-sqrh8ylt | A review Cryoglobulinemia: recent findings in cutaneous and extracutaneous manifestations Dermatological manifestations of hepatitis C Hepatitis C and the skin Peripheral neuropathy in mixed cryoglobulinemia: clinical and electrophysiologic investigations Hepatitis C infection, cryoglobulinemia, and vasculitic neuropathy Cryoglobulinaemic neuropathy: lack of progression in patients with good haematological control Cryoglobulinemic peripheral neuropathy: neurophysiologic evaluation in twenty- two patients Peripheral neuropathy associated with essential mixed cryoglobulinaemia: a role for hepatitis C virus infection? |
| cord-270091-sqrh8ylt | A syndrome with distinct clinical and pathologic features A case of central nervous system vasculitis related to an episode of Guillain- Barre syndrome Vasculitis in cytomegalovirus infection Polyarteritis nodosa associated with acute cytomegalovirus infection Polyarteritis nodosa and cytomegalovirus: diagnosis by polymerase chain reaction Cytomegalovirus infection in systemic necrotizing vasculitis: causative agent or opportunistic infection? |
| cord-270091-sqrh8ylt | A trigger mechanism? |
| cord-270091-sqrh8ylt | Atteinte neurologique centrale et virus de l'hépatite C Essential mixed cryoglobulinemia as a cause of ischemic cerebrovascular accident Essential mixed cryoglobulinemia as a cause of gastrointestinal hemorrhage Hepatitis C and mixed cryoglobulinemia: a case of primary gastrointestinal necrotising vasculitis Relapsing ischemic encephaloenteropathy and cryoglobulinemia Hepatitis C and Sjögren's syndrome Sicca syndrome associated with hepatitis C virus infection Sicca syndrome and hepatitis C virus infection: a Gougerot- Sjogren pseudo- syndrome? |
| cord-270091-sqrh8ylt | révélatrice d'une infection à parvovirus B19 Henoch- Schoenlein purpura and human parvovirus infection Henoch- Schonlein purpura and human parvovirus B19 Prevalence of human parvovirus B19 in children with Henoch- Schoenlein purpura Testing for parvovirus B19 in Henoch- Schonlein syndrome? |
| cord-026340-2nf97zvc | : what to expect for COVID-19? |
| cord-026340-2nf97zvc | Does CQ have anti- viral effects? |
| cord-026340-2nf97zvc | How did COVID-19 originate? |
| cord-026340-2nf97zvc | How does CQ help eliminate malarial parasite? |
| cord-026340-2nf97zvc | How effective can be CQ against SARS? |
| cord-026340-2nf97zvc | How long has it been since we know chloroquine( CQ, 9-aminoquinoline)? |
| cord-026340-2nf97zvc | PPT1 promotes tumor growth and is the molecular target of chloroquine derivatives in cancer Inhibition of betulinic acid to growth and angiogenesis of human colorectal cancer cell in nude mice Effects of chloroquine on viral infections: an old drug against today's diseases? |
| cord-026340-2nf97zvc | What are the possible ways SARS- CoV2 infect a host cell? |
| cord-026340-2nf97zvc | What are the symptoms of COVID-19? |
| cord-026340-2nf97zvc | What governs the affinity of a virus towards the human host cell? |
| cord-026340-2nf97zvc | What is COVID-19? |
| cord-285935-5rsk6g7l | How Far Are We? |
| cord-282628-6uoberfu | How do the virulence factors of shigella work together to cause disease? |
| cord-282628-6uoberfu | What is flux balance analysis? |
| cord-280878-1kt51viz | A new structural label for infrared spectroscopy Conductance and amantadine binding of a pore formed by a lysine- flanked transmembrane domain of SARS coronavirus envelope protein Model of a putative pore: The pentameric α- helical bundle of SARS coronavirus E protein in lipid bilayers Protein- protein interactions of viroporins in coronaviruses and paramyxoviruses: New targets for antivirals? |
| cord-280878-1kt51viz | The SARS coronavirus E protein interacts with PALS1 and alters tight junction formation and epithelial morphogenesis Functional role of human immunodeficiency virus type 1 vpu Detection of drug- induced conformational change of a transmembrane protein in lipid bilayers using site- directed spin labeling Do viral proteins possess unique biophysical features? |
| cord-286219-qcx5ehnh | What has the study of the K3 and K5 viral ubiquitin E3 ligases taught us about ubiquitin- mediated receptor regulation? |
| cord-274306-cxvnv8dy | H5N1 de Hong- Kong avait- il entraîné des infections d'une telle gravité chez l'homme? |
| cord-274306-cxvnv8dy | a mechanism for unusual severity of human disease? |
| cord-274306-cxvnv8dy | cul- de- sac épidémiologique ou prémices d'une nouvelle pandémie? |
| cord-274306-cxvnv8dy | les changements climatiques sont- ils en cause? |
| cord-286719-1xjmlwqr | Cytomegalovirus: pathogen, paradigm, and puzzle International consensus guidelines on the management of cytomegalovirus in solid organ transplantation Neonatal cytomegalovirus blood load and risk of sequelae in symptomatic and asymptomatic congenitally infected newborns Is HCMV a tumor promoter? |
| cord-279418-3r1ijafm | Endoplasmic Reticulum- Golgi Intermediate Compartment Membranes and Vimentin Filaments Participate in Vaccinia Virus Assembly Replication of African Swine Fever Virus DNA in Infected Cells Cytoplasmic Organization of POXvirus DNA Replication Aggresomes and Pericentriolar Sites of Virus Assembly: Cellular Defense or Viral Design? |
| cord-279418-3r1ijafm | This arrangement leads to the interaction of both( n+1) th Virus factories: associations of cell organelles for viral replication and morphogenesis Virus factories, double membrane vesicles and viroplasm generated in animal cells Virus factories: biogenesis and structural design Biomolecular condensates: organizers of cellular biochemistry Germline P Granules Are Liquid Droplets That Localize by Controlled Dissolution/ Condensation Droplet organelles? |
| cord-021375-lca26xum | ( Crawford 2007, 213) How do we live in harmony with the microbial world but still prevent infectious diseases from developing? |
| cord-021375-lca26xum | : On the Possibility of Life in Capitalist Ruins Human Endogenous Retroviruses( Hervs) and Autoimmune Rheumatic Disease: Is There a Link? |
| cord-021375-lca26xum | Alive? |
| cord-021375-lca26xum | As the human can not be thought without the virus, and attempts to alter or eliminate it( in)directly also affect the human, how might we think differently about urban spaces and public health if we consider the human and the virus not as opposed but as fundamentally interrelated? |
| cord-021375-lca26xum | Considering recent advances in gene sequencing in microbiology, through which a"vast diversity of microbial life in, on and around the human body"( Lorimer 2017, 544) has been identified as residing in complex relationality with one another, how befitting is it to fight infectious diseases by indiscriminately eliminating microbes through the use of antimicrobials and practicing urban hygiene as in the case of Hong Kong? |
| cord-021375-lca26xum | Creating the North American Landscape What Is a Pathogen? |
| cord-021375-lca26xum | How can a microbial approach to global health security protect life? |
| cord-021375-lca26xum | How can this emerging ontological and epistemological understanding of human life inform the governance of disease? |
| cord-021375-lca26xum | How do we move from a potentially destructive antimicrobial perspective such as is embodied in Hong Kong to a microbial perspective in which we take responsibility for our vital relation with the microbial world? |
| cord-021375-lca26xum | How then can human efforts be conceived to control pathogenic, while fostering benign, viral circulation? |
| cord-021375-lca26xum | Human Placental Morphogenesis Only Human? |
| cord-021375-lca26xum | What are the implications of this understanding of the human body as mostly microbial to the way we fight infectious diseases in global cities and elsewhere? |
| cord-021375-lca26xum | What happens when the enemy is not the virus or other microbes but us( Methot and Alizon 2014, 778)? |
| cord-278684-txlvla0j | Actions and mechanisms of action Natural and experimental Borna disease in animals Borna disease, a possible hazard for man? |
| cord-278684-txlvla0j | Borna disease virus: A possible etiologic factor for human affective disorders? |
| cord-284523-lknyehsa | A 2( sPLA 2): friends or foes? |
| cord-284523-lknyehsa | Are they actors in antibacterial and anti- HIV resistance? |
| cord-281844-c0uhcatg | Role of respiratory viruses and allergen sensitization Associations between environmental exposures and asthma control and exacerbations in young children: a systematic review Smoke- free legislation and hospitalizations for childhood asthma Personal exposure to nitrogen dioxide( NO 2) and the severity of virus- induced asthma in children Health effects of indoor nitrogen dioxide and passive smoking on urban asthmatic children Environmental tobacco smoke exposure and nocturnal symptoms among inner- city children with asthma Results of a home- based environmental intervention among urban children with asthma Guidelines reduce X- ray and blood gas utilization in acute asthma Basic Research on virus- induced asthma exacerbation: inhibition of inflammatory chemokine expression by fluticasone propionate Respiratory viral infections in children with asthma: do they matter and can we prevent them? |
| cord-281844-c0uhcatg | key: cord-281844-c0uhcatg authors: Costa, Lusmaia D.C.; Costa, Paulo Sucasas; Camargos, Paulo A.M. title: Exacerbation of asthma and airway infection: is the virus the villain? |
| cord-273777-qb0vp9gr | An In Vitro Study Fertility and infertility: Definition and epidemiology Anaerobes and Bacterial Vaginosis in Pregnancy: Virulence Factors Contributing to Vaginal Colonisation Risks associated with bacterial vaginosis in infertility patients: A systematic review and meta- analysis Bacterial vaginosis and infertility: Cause or association? |
| cord-273777-qb0vp9gr | Healthy human gut phageome Dysbiosis in inflammatory bowel disease: A role for bacteriophages? |
| cord-273777-qb0vp9gr | Vaginal bacterial phaginosis? |
| cord-273777-qb0vp9gr | cord-273777-qb0vp9gr authors: Happel, Anna- Ursula; Varsani, Arvind; Balle, Christina; Passmore, Jo- Ann; Jaspan, Heather title: The Vaginal Virome — Balancing Female Genital Tract Bacteriome, Mucosal Immunity, and Sexual and Reproductive Health Outcomes? |
| cord-286559-y8z0pwgn | Walking along the rabies genome: is the large G- L intergenic region a remnant gene? |
| cord-283880-lrrkuist | A novel rhabdovirus associated with acute hemorrhagic fever in central Africa Viral evolution: beyond drift and shift Rapid metagenomic identification of viral pathogens in clinical samples by real- time nanopore sequencing analysis Depletion of Abundant Sequences by Hybridization( DASH): using Cas9 to remove unwanted high- abundance species in sequencing libraries and molecular counting applications Viral metagenomics: are we missing the giants? |
| cord-283880-lrrkuist | a paradigm shift in evolutionary biology? |
| cord-277309-kelebqr6 | : what can they teach us about the severe acute respiratory syndrome? |
| cord-277309-kelebqr6 | A comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special? |
| cord-277309-kelebqr6 | Current Opinion in Virology 2019, 34:79- 89 Bats as a continuing source of emerging infections in humans Mass extinctions, biodiversity and mitochondrial function: are bats'special'as reservoirs for emerging viruses? |
| cord-277392-s0bldxg9 | How do animal DNA viruses get to the nucleus? |
| cord-277392-s0bldxg9 | How do these particles manage to leave the cell surface? |
| cord-277392-s0bldxg9 | WHY DO THESE OBSCURE DETAILS MATTER? |
| cord-277392-s0bldxg9 | Why all the fuss? |
| cord-288879-rj03dsib | This leads to the question: what possible functions could they serve for the virus itself or interaction with host cells? |
| cord-286137-4cbh3u3z | Could nutrition also actively shape how viruses evolve? |
| cord-286137-4cbh3u3z | So, do viruses harboring higher genetic diversity initially fare better in establishing an infection and displaying virulent phenotypes? |
| cord-281281-knelqmzx | A fight for supremacy Type 1 interferons and the virus- host relationship: A lesson in détente Viruses and Interferons Recent insights into emerging coronaviruses Clinical characteristics of coronavirus disease 2019 in China Coronavirus infections and immune responses Complement activation contributes to severe acute respiratory syndrome coronavirus pathogenesis Complement as a target in COVID-19? |
| cord-281281-knelqmzx | Should we stimulate or suppress immune responses in COVID-19? |
| cord-280429-4fota9rl | A new DNA binding protein highly conserved in diverse crenarchaeal viruses Structure of A197 from Sulfolobus turreted icosahedral virus: A crenarchaeal viral glycosyltransferase exhibiting the GT- A fold The bacterial conjugation protein TrwB resembles ring helicases and F1-ATPase Structure of the VirB4 ATPase, alone and bound to the core complex of a type IV secretion system Polintons: A hotbed of eukaryotic virus, transposon and plasmid evolution Virophages or satellite viruses? |
| cord-280429-4fota9rl | Archaeal viruses: Living fossils of the ancient virosphere? |
| cord-280429-4fota9rl | What does structure tell us about virus evolution? |
| cord-288734-xinkqs6u | Ebola hemorrhagic fever: why were children spared? |
| cord-275538-c44gmu22 | Efficacy of the vaccine( does the vaccine prevent infection or simply ameliorate some signs or length of the disease?) |
| cord-275538-c44gmu22 | If an owner brings a Labrador Retriever puppy to the veterinarian for''whatever vaccines it needs,''it is up to the practitioner to ask:''Will it be a hunting dog, will it be used in field trials, or will it be exposed to wildlife and waterways?'' |
| cord-275538-c44gmu22 | Morbidity and mortality associated with the specific disease( does the organism cause serious illness, or does it cause a mild transient disease that may pose only minimal risk to the individual or population?) |
| cord-275538-c44gmu22 | Risks associated with administering the vaccine( are the risks associated with that vaccine greater than the risk of the disease?) |
| cord-283405-aozxvxxs | Do the placental barrier, parasite genotype and Toll- like receptor polymorphisms contribute to the course of primary infection with various Toxoplasma gondii genotypes in pregnant women? |
| cord-283405-aozxvxxs | The effects of yellow fever immunization( 17DD) inadvertently used in early pregnancy during a mass campaign in Brazil Should expectant mothers be vaccinated against flu? |
| cord-283405-aozxvxxs | What does epidemiology tell us about risk factors for herpes zoster? |
| cord-022262-ck2lhojz | But what about receptor specificity of these viruses? |
| cord-022262-ck2lhojz | Do these considerations allow us to safely conclude that, after its global eradication, poliovirus will have no chance to re- emerge through enterovirus evolution? |
| cord-022262-ck2lhojz | Does the history of the polyprotein determine how picornaviruses may evolve in the future? |
| cord-022262-ck2lhojz | For example, the precursor 3CD pr~ can be cleaved into 3C pr~ and 3CD p~ by a( cis?) cleavage in which the 3C/3CD pr~ proteinase is involved. |
| cord-022262-ck2lhojz | Genetic analyses have indicated that template switching occurs( predominantly?) |
| cord-022262-ck2lhojz | How do the multiple mechanisms alluded to interlace to produce a specific picornavirus disease syndrome? |
| cord-022262-ck2lhojz | How it is Likely to Evolve in the Future? |
| cord-022262-ck2lhojz | Moreover, if the genome has to be translated for replication to occur, how can inhibition of translation promote RNA synthesis? |
| cord-022262-ck2lhojz | The mechanism of RNA recombination in poliovirus Primary structure, gene organization and polypeptide expression of poliovirus RNA The poliovirus receptor protein is produced both as membrane- bound and secreted forms Transgenic mice susceptible to poliovirus Q[3 replicase as repressor of Q[3 RNA- directed protein synthesis Evolution of RNA genomes: does the high mutation rate necessitate high rate of evolution of viral proteins? |
| cord-022262-ck2lhojz | We have discussed different aspects relevant to picornavirus evolution, but we did not address one crucial question: Are picornaviruses a successful family? |
| cord-022262-ck2lhojz | What are the mechanisms by which the picornaviruses and other RNA virus families have diversified? |
| cord-022262-ck2lhojz | What is the identity of picornaviruses? |
| cord-022262-ck2lhojz | What is the mechanism by which poliovirus may eliminate foreign sequences? |
| cord-290282-oxyzndsj | The nucleolus- a gateway to viral infection? |
| cord-269623-9pxdeva3 | Does influenza vaccination prevent asthma exacerbations in children? |
| cord-269623-9pxdeva3 | Is this a sign that I really did become a better doctor or is it a symptom of ageing? |
| cord-269623-9pxdeva3 | Learning from experience? |
| cord-269623-9pxdeva3 | Lethal H5N1 influenza viruses escape host anti- viral cytokine responses Induction of proinflammatory cytokines in human macrophages by influenza A( H5N1) viruses: a mechanism for the unusual severity of human disease? |
| cord-269623-9pxdeva3 | The efficacy of influenza vaccine in elderly persons: a meta- analysis and review of the literature Relation between influenza vaccination and outpatient visits, hospitalization, and mortality in elderly persons with chronic lung disease Is immunizing all patients with chronic lung disease in the community against influenza cost- effective? |
| cord-269623-9pxdeva3 | Were my early errors more influential on my subsequent practice or are my current errors not recognised or not made known to me by sympathetic colleagues? |
| cord-269623-9pxdeva3 | were they the donors of the''internal''genes of H5N1 viruses in Hong Kong? |
| cord-282204-j1slaefb | -a review Clinical characterization of acute and convalescent illness of confirmed chikungunya cases from Chiapas, S. Mexico: a cross sectional study Evaluation of mosquito fish Gambusia affinis in the control of mosquito breeding in rice fields Laboratory diagnosis of chikungunya virus: do we really need it? |
| cord-282204-j1slaefb | Guidelines on Clinical Management of Chikungunya Fever Guidelines on Clinical Management Monitoring and Managing Insecticide Resistance in Aedes mosquito Populations- Interim Guidance for Entomologists Imipramine inhibits Chikungunya virus replication in human skin fibroblasts through interference with Transgenic mosquitoes-fact or fiction? |
| cord-282204-j1slaefb | past, present, and future Mosquito control with green nanopesticides: towards the one Health approach? |
| cord-290432-4dli5emd | Australian Government Disease burden and health- care clinic attendances for young children in remote aboriginal communities of northern Australia Can linked emergency department data help assess the out- of- hospital burden of acute lower respiratory infections? |
| cord-287466-ag5y781z | Black tiger breeding program yields record shrimp harvests in Australia Induction of antiviral immunity by double- stranded RNA in a marine invertebrate Double- stranded RNA induces sequence- specific antiviral silencing in addition to nonspecific immunity in a marine shrimp, convergence of RNA interference and innate immunity in the invertebrate antiviral response? |
| cord-287466-ag5y781z | Structure of newly found lymphoid organ Suppression of PmRab7 by dsRNA inhibits WSSV or YHV infection in shrimp Putative spawner- isolated mortality virus associated with mid- crop mortality syndrome in farmed Penaeus monodon from northern Australia Multiplex real- time PCR and high- resolution melting analysis for detection of white spot syndrome virus, yellow- head virus, and Penaeus monodon densovirus in penaeid shrimp Similarity between the histopathology of white spot syndrome virus and yellow head syndrome virus and its relevance to diagnosis of YHV disease in the Americas Latent yellow- head infections in Penaeus monodon and implications regarding disease resistance or tolerance Nidovirus transcription, how to make sense …? |
| cord-253705-utp8po48 | ( 1- 1) Why do some of these viruses have both functions on the same molecule, while others have the functions on separate molecules? |
| cord-253705-utp8po48 | ( 1- 2) Why do Sia- binding enveloped MERS- CoV and TGEV and non- enveloped viruses( even though the genus Siadenovirus contains a putative sialidase homologue gene for which the function is not known[ 143]) not encode an RDE? |
| cord-253705-utp8po48 | ( 1- 3) While influenza A viruses must acquire the ability to bind to α2- 6Sia human- type receptors for efficient transmission among humans, why do NAs of all influenza A viruses keep cleavage specificity for α2- 3Sia? |
| cord-253705-utp8po48 | Are there different roles? |
| cord-253705-utp8po48 | For example, why do all three known enteric HAdVs have two spikes( fibers), while other HAdVs need only one primary receptor- binding spike? |
| cord-253705-utp8po48 | How can these viruses be released from traps by decoy Sia receptors such as those on mucins? |
| cord-253705-utp8po48 | How can these viruses be released/ spread from α2- 6Sia- decoy mucins or infected cells? |
| cord-253705-utp8po48 | Why are HE proteins present in some but not all toroviruses and coronaviruses? |
| cord-253705-utp8po48 | Why do all VPs contain the same receptor- binding site? |
| cord-253705-utp8po48 | Why do short fibers of HAdV species F not bind to Sia like short fibers of species G do? |
| cord-289360-h6wvx7gw | A strategy to estimate unknown viral diversity in mammals Is the debate and"pause"on experiments that alter pathogens with pandemic potential influencing future plans of graduate students and postdoctoral fellows? |
| cord-289360-h6wvx7gw | mBio Is virology dead? |
| cord-275795-ee7qyw5h | Alpha- beta T cells provide protection against lethal encephalitis in the murine model of VEEV infection Correlates of protective immunity in poxvirus infection: where does antibody stand? |
| cord-275795-ee7qyw5h | Circulating rotavirus- specific T cells have a poor functional profile Fulfilling the promise of rotavirus vaccines: how far have we come since licensure? |
| cord-275795-ee7qyw5h | Intracellular IFN- gamma expression in natural killer cells precedes lung CD8 þ T cell recruitment during respiratory syncytial virus infection HBV pathogenesis in animal models: recent advances on the role of platelets Basis of rabies virus neurovirulence in mice: expression of major histocompatibility complex class I and class II mRNAs Postlicensure effectiveness of varicella vaccine during an outbreak in a child care center Management of rabies in humans Vaccinia virus vaccines: past, present and future Hepatitis A virus in West Africa: is an epidemiological transition beginning? |
| cord-275795-ee7qyw5h | The T¼4 envelope of Sindbis virus is organized by interactions with a complementary T¼3 capsid Bystander target cell lysis and cytokine production by dengue virus- specific human CD4(þ) cytotoxic T- lymphocyte clones What is immune privilege( not)? |
| cord-275795-ee7qyw5h | The global burden of viral hepatitis from Analysis of T cell responses during active varicella- zoster virus reactivation in human ganglia REVIEW PAPER: pathology of animal models of alphavirus encephalitis Interview about immune privilege with Memory CD8 T cells in RSV infection: friend or foe? |
| cord-293472-d3iwlpsr | Does this patient have influenza? |
| cord-285462-9i61rsei | : how eff ective are political fact- checkers? |
| cord-285462-9i61rsei | A feasibility analysis of emergency management with cloud computing integration Natural language processing to the rescue? |
| cord-285462-9i61rsei | An urgent need for clarity during the COVID-19 infodemic Defining misinformation, disinformation and malinformation: An urgent need for clarity during the COVID-19 infodemic A resistant strain: Revealing the online grassroots rise of the antivaccination movement COVID-19 Snapshot MOnitoring( COSMO): monitoring knowledge, risk perceptions, preventive behaviours, and public trust in the current coronavirus outbreak An economic constraint: can we'expand the frontier'in the fight against Covid-19? Working paper# covid-19 on twitter: |
| cord-284880-xsh3wkqy | : Is there a risk of transmission by ventilation or air conditioning systems? |
| cord-284880-xsh3wkqy | Influenza virus transmission is dependent on relative humidity and temperature Droplet fate in indoor environments, or can we prevent the spread of infection? |
| cord-284880-xsh3wkqy | Why, when and how do HVAC- systems pollute the indoor environment and what to do about it? |
| cord-284479-75zgljet | Can you teach old drugs new tricks? |
| cord-284479-75zgljet | How Far Are We? |
| cord-284479-75zgljet | Luciferase- expressing Ebolaviruses as tools for screening of antivirals Emerging virus diseases: can we ever expect the unexpected? |
| cord-282742-eyukbot7 | Short RNAs that silence gene expression Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells Pathogenesis of flavivirus infections: Using and abusing the host cell Mechanisms of posttranscriptional regulation by microRNAs: Are the answers in sight? |
| cord-282742-eyukbot7 | Target recognition and regulatory functions Control of arbovirus diseases: Is the vector the weak link? |
| cord-282742-eyukbot7 | genome Human cellular microRNA hsa- miR-29a interferes with viral nef protein expression and HIV-1 replication RNA interference mediated inhibition of dengue virus multiplication and entry in HepG2 cells Approaches for chemically synthesized siRNA and vector- mediated RNAi Effective siRNA targeting of the 3'untranslated region of the West Nile virus genome Use of RNA interference to prevent lethal murine west nile virus infection Yellow fever vaccine- How does it work and why do rare cases of serious adverse events take place? |
| cord-292575-vsswxwdi | recommendations from the CDC Working Group Microbial threat lists: obstacles in the quest for biosecurity? |
| cord-288238-36hiiw91 | Does nitric oxide play a critical role in viral infections? |
| cord-288238-36hiiw91 | Why do cancers have high aerobic glycolysis? |
| cord-288238-36hiiw91 | van der Poll T. Hyperglycemia enhances coagulation and reduces neutrophil degranulation, whereas hyperinsulinemia inhibits fibrinolysis during human endotoxemia High glucose disrupts oligosaccharide recognition function via competitive inhibition: a potential mechanism for immune dysregulation in diabetes mellitus Polymorphonuclear leukocytes in non- insulin- dependent diabetes mellitus: abnormalities in metabolism and function Increased susceptibility of diabetic mice to influenza virus infection: compromise of collectin- mediated host defense of the lung by glucose? |
| cord-292657-gq3965se | The presence of SARS- CoV-2 RNA in feces of COVID-19 patients Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China Origin and evolution of pathogenic coronaviruses Phylogenetic network analysis of SARS- CoV-2 genomes Bat origin of human coronaviruses Influenza virus infectivity is retained in aerosols and droplets independent of relative humidity Effect of host species on the distribution of mutational fitness effects for an RNA virus Molecular evolution of MERS coronavirus: dromedaries as a recent intermediate host or longtime animal reservoir? |
| cord-288111-0ufc54kw | Histopathologic abnormalities consist of new demyelinative lesions infiltrated by mononuclear cells located primarily in the brain stem and the spinal cord.? |
| cord-288111-0ufc54kw | In this context it is of interest to note that in postinfectious encephalomyelitis in man associated with rubella, varicella, or measles, an MBP- specific lymphoproliferative response has been observed?'4. |
| cord-288111-0ufc54kw | This observation led to an interesting experiment in which a rabbit was immunized with a synthetic peptide from such a sequence of the hepatitis B virus polymerase?' |
| cord-293732-rxd1lyi7 | Will Coronavirus Pandemic Diminish by Summer? |
| cord-290617-45be6gxe | G cytidine deaminase association with coronavirus nucleocapsid protein Evidence for host- dependent RNA editing in the transcriptome of SARS- CoV-2 Human coronaviruses: what do they cause? |
| cord-290617-45be6gxe | Why is CpG suppressed in the genomes of virtually all small eukaryotic viruses but not in those of large eukaryotic viruses? |
| cord-278876-il7g78w1 | Characterization of the human papillomavirus( HPV) integration sites into genital cancers Lethal mutagenesis of hepatitis C virus induced by favipiravir Virus and host factors affecting the clinical outcome of bluetongue virus infection Ongoing clinical trials of human immunodeficiency virus latency- reversing and immunomodulatory agents Is virology dead? |
| cord-278876-il7g78w1 | Is microcephaly among some neonates just the tip of the neurological iceberg? |
| cord-278876-il7g78w1 | When and how should infants be tested for possible congenital Zika infection? |
| cord-278876-il7g78w1 | Why does the overall risk of microcephaly and other birth defects seem to differ in other parts of Latin America and the Caribbean, compared to Brazil? |
| cord-278876-il7g78w1 | straight or cocktail? |
| cord-290548-0wezrr1b | A pandemic warning? |
| cord-290548-0wezrr1b | title: Villains or heroes? |
| cord-294585-dl5v9p50 | the development of haemophilia A therapeutics-from whole blood transfusion to recombinant DNA to gene therapy Sterilization of hepatitis and HTLV- III viruses by exposure to tri( n- butyl) phosphate and sodium cholate Current status of solvent/ detergenttreated frozen plasma Venous thromboembolism associated with the management of acute thrombotic thrombocytopenic purpura A process for solvent/ detergent treatment of plasma for transfusion at blood centers using a disposable bag system Removal of small non- enveloped viruses by nanofiltration Virus inactivation in blood components by photoactive phenothiazine dyes Methylene blue treated fresh- frozen plasma: what is its contribution to blood safety? |
| cord-270803-jtv5jmkn | Mass extinctions, biodiversity and mitochondrial function: are bats ‘ special ’ as reservoirs for emerging viruses? |
| cord-270803-jtv5jmkn | Olival KJ, Epstein JH, Wang L- F, Field HE, Daszak P: Are bats unique virus reservoirs? |
| cord-270803-jtv5jmkn | Purely a numbers game: more bat species= more viruses? |
| cord-270803-jtv5jmkn | So the question ‘ Are bats different, special or exceptional? ’ |
| cord-270803-jtv5jmkn | So the question'Are bats different, special or exceptional?'has become a focal point in the field of virology, bat biology and virus- host co- evolution. |
| cord-270803-jtv5jmkn | The most recent paper out of a series studies on astroviruses conducted by the Hong Kong group, which demonstrated that the genetic diversity of astroviruses in bats is greater than those in other mammals Evolutionary insights into the ecology of coronaviruses Emergence and persistence of hantaviruses Virus evolution and genetic diversity of hantaviruses and their rodent hosts Evolution of the Old World Arenaviridae and their rodent hosts: generalised host- transfer or association by descent? |
| cord-270803-jtv5jmkn | The question'Are bats different?'has been raised at many international conferences and has been the topic of several previous reviews[ 1, 2,20,23]. |
| cord-270803-jtv5jmkn | they linked? |
| cord-285547-7m3dh8hu | H9N2 influenza viruses from Israeli poultry: a five- year outbreak Human infection with an avian H9N2 influenza A virus in Hong Kong in 2003 H9N2 subtype influenza A viruses in poultry in Pakistan are closely related to the H9N2 viruses responsible for human infection in Hong Kong Continuing evolution of H9N2 influenza viruses in Southeastern China Phylogeography and evolutionary history of reassortant H9N2 viruses with potential human health implications Genetic evolution of H9 subtype influenza viruses from live poultry markets in Shanghai Molecular characterization of H9N2 influenza viruses: were they the donors of the''internal''genes of H5N1 viruses in Hong Kong? |
| cord-285547-7m3dh8hu | The genesis and evolution of H9N2 influenza viruses in poultry from southern China Characterization of a non- pathogenic H5N1 influenza virus isolated from a migratory duck flying from Siberia in Hokkaido Evaluation of the reverse transcription loopmediated isothermal amplification( RT- LAMP) as a screening method for the detection of influenza viruses in the fecal materials of water birds Genetic diversity of H9N2 influenza viruses from pigs in China: a potential threat to human health? |
| cord-285547-7m3dh8hu | The neighbor- joining method: a new method for reconstructing phylogenetic trees Characterization of H5N1 highly pathogenic avian influenza virus strains isolated from migratory waterfowl in Mongolia on the way back from the southern Asia to their northern territory Pandemic influenza: a zoonosis? |
| cord-288703-wdh1jiry | In your opinion, are we on track to achieve those goals? |
| cord-288703-wdh1jiry | What is the current status of visceral leishmaniasis? |
| cord-288703-wdh1jiry | Which pressing steps should be taken to reduce it? |
| cord-288703-wdh1jiry | Why? |
| cord-292830-gcfx1095 | ; could statins fill gap? |
| cord-292830-gcfx1095 | A DNA transfection system for generation of influenza A virus from eight plasmids Pleiotropic mechanisms of ribavirin antiviral activities Emerging virus diseases: can we ever expect the unexpected? |
| cord-292416-3hhi4wps | The next outbreak? |
| cord-292416-3hhi4wps | what can they teach us about the severe acute respiratory syndrome? |
| cord-294568-12eyo13f | Human bocavirus in Chile: clinical characteristics and epidemiological profile in children with acute respiratory tract infections Does respiratory virus coinfection increases the clinical severity of acute respiratory infection among children infected with respiratory syncytial virus? |
| cord-294568-12eyo13f | Is virus coinfection a predictor of severity in children with viral respiratory infections? |
| cord-293540-45awgabp | 2 Is the aim of these strategies to protect sex workers or to protect public health via protection of sex workers? |
| cord-293540-45awgabp | If the outcome is the same either way, does the intent make a diff erence? |
| cord-286741-h3oix9zc | History of swine influenza viruses in Asia Genetics, evolution, and the zoonotic capacity of European swine influenza viruses Sowing the seeds of a pandemic? |
| cord-286741-h3oix9zc | However, DPP4 of frequently used small The designation of"O"means that there are many studies using the animal for the purposed study The designation of"?"means that there are no or not many studies using the animal for the purposed study animal models like mouse, hamster, and ferret did not bind to MERS- CoV[ 128]. |
| cord-286741-h3oix9zc | The designations of"O"and"?"are the same as in Table 1 appeared to be well replicated( 59/63) in the middle or lower respiratory tract, regardless of the presence of swine PB2 or avian PB2, although all but one reassortants( 62/63) contained the swine HA. |
| cord-290352-0pc5eji4 | Initial genetic characterization of the 1918"Spanish"influenza virus Pathology of fatal human infection associated with avian influenza A H5N1 virus Avian influenza A( H5N1) in 10 patients in Vietnam Safety and immunogenicity of a recombinant hemagglutinin vaccine for H5 influenza in humans Human illness from avian influenza H7N3, British Columbia Influenza H5N1 replication sites in humans Probable person- to- person transmission of avian influenza A( H5N1) Responsiveness to a pandemic alert: use of reverse genetics for rapid development of influenza vaccines Are we ready for pandemic influenza? |
| cord-290352-0pc5eji4 | The structure and receptor binding properties of the 1918 influenza hemagglutinin Cellular transcriptional profiling in influenza A virus- infected lung epithelial cells: the role of the nonstructural NS1 protein in the evasion of the host innate defense and its potential contribution to pandemic influenza Comparison of efficacies of RWJ-270201, zanamivir, and oseltamivir against H5N1, H9N2, and other avian influenza viruses Emergence of multiple genotypes of H5N1 avian influenza viruses in Hong Kong SAR H5N1 influenza: a protean pandemic threat Molecular characterization of H9N2 influenza viruses: were they the donors of the"internal"genes of H5N1 viruses in Hong Kong? |
| cord-290352-0pc5eji4 | a mechanism for the unusual severity of human disease? |
| cord-291113-iizj932l | About It? |
| cord-291113-iizj932l | Some Factors Affecting the Survival of Airborne Viruses Do exposures to aerosols pose a risk to dental professionals? |
| cord-298019-gf2asni1 | The preference of tryptophan for membrane interfaces Use of hydrophobic moment plot methodology to aid the identification of oblique orientated α- helices Antimicrobial peptides and viral fusion peptides: how different they are? |
| cord-297203-f3f31h4r | Replication- deficient ebolavirus as a vaccine candidate Single- dose immunization with virus replicon particles confers rapid robust protection against Rift Valley fever virus challenge Virus- like particles in vaccine development Virus- like particles as particulate vaccines Formulation and stabilization of recombinant protein based virus- like particle vaccines Vaccines for the 21st century DNA vaccines: recent developments and future possibilities DNA vaccines-back in the saddle again? |
| cord-297203-f3f31h4r | The yellow fever 17D virus as a platform for new live attenuated vaccines From research to hase III: preclinical, industrial and clinical development of the Sanofi Pasteur tetravalent dengue vaccine Creation of a recombinant Rift Valley fever virus with a two- segmented genome IRES dependent replication of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells IRES- based Venezuelan equine encephalitis vaccine candidate elicits protective immunity in mice Modulation of poliovirus replicative fitness in HeLa cells by deoptimization of synonymous codon usage in the capsid region Development of live attenuated arenavirus vaccines based on codon deoptimization Adenoviruses as vaccine vectors Pre- existing immunity against Ad vectors: humoral, cellular, and innate response, what's important? |
| cord-297662-slmlhqnb | What Do We Know? |
| cord-302111-kg0dmgq0 | cause recurrent wheeze of early childhood and asthma? |
| cord-293421-0ksn0fc7 | I? |
| cord-293421-0ksn0fc7 | spir{}chete Borrelia blt~:&~dorfi, Ji itsing th{: i}{}lymerase clmi, t reaction P{}h'nlerase chain reaction: a rev{}l- uti{}n ill diagn{}sis{'} f ocular lcishmaniosis? |
| cord-292075-t9z7zqz4 | Quelle sera l'influence du changement climatique sur les diffusions des maladies émergentes? |
| cord-292075-t9z7zqz4 | la voie digestive à partir de la viande de singe mal cuite est- il possible? |
| cord-292075-t9z7zqz4 | épidémique du VIH dans les années 80? |
| cord-293975-np9xdag5 | An antisense? |
| cord-293975-np9xdag5 | Infection of perirhinal cortex was seen in all cases at day 3? |
| cord-293975-np9xdag5 | viru? |
| cord-287286-4l963z2q | Are these changes in gene expression a result of a virus- host interaction disruption? |
| cord-287286-4l963z2q | But why are such changes occurring at a low frequency in infected populations? |
| cord-287286-4l963z2q | But why do only a few HPV infections result in malignancy? |
| cord-287286-4l963z2q | If the immature virus contains an incomplete shell, how is the virus released from the cell? |
| cord-031840-k9l91unc | But what is the meaning of COVID-19 when the current pandemic is over? |
| cord-031840-k9l91unc | But what is"normal"in this case? |
| cord-031840-k9l91unc | But what then does it mean, the pandemic? |
| cord-031840-k9l91unc | COVID-19 can justifiably be called"novel,"but is n't every virus novel in its own way and at some moment in time? |
| cord-031840-k9l91unc | How does such depiction envisage China's relations with neighboring countries and its position in the area? |
| cord-031840-k9l91unc | How, then, is the East Asian encounter with COVID-19 depicted in the Chinese public discourse? |
| cord-031840-k9l91unc | If so, in what way and to what extent? |
| cord-031840-k9l91unc | In addition to biomedical measures, a more critical question for the coronavirus crisis is"what method does the matter demand"( Thompson, 2018, p. 13)? |
| cord-031840-k9l91unc | Is n't being novel the normal course of event in life and in life sciences as well? |
| cord-031840-k9l91unc | Is the world, old or new, ever normal? |
| cord-031840-k9l91unc | There are norms regulating life, but has there ever been a"normal life"as such? |
| cord-031840-k9l91unc | What does it mean, the plague? |
| cord-031840-k9l91unc | What does"being normal"mean exactly? |
| cord-031840-k9l91unc | Will it be remembered? |
| cord-280427-smqc23vr | Are other species such as mosquitoes, houseflies responsible for the transmission of virus to humans? |
| cord-280427-smqc23vr | Are there any precautions to be taken with live animals or animal products? |
| cord-280427-smqc23vr | Can companion animals become infected with Covid-19? |
| cord-280427-smqc23vr | Can your pet get COVID-19? |
| cord-280427-smqc23vr | How to protect pets if you are sick? |
| cord-280427-smqc23vr | The role of environmental factors to transmission of SARS- CoV-2( COVID-19) Is COVID-19 the first pandemic that evolves into a panzootic? |
| cord-292353-z86rjwle | : Variations on a theme? |
| cord-292353-z86rjwle | Are the 5'ends of influenza viral mRNAs synthesized in vivo donated by host mRNAs? |
| cord-292353-z86rjwle | Friend or foe in immunity to infection? |
| cord-297131-3a9vjpvn | Vaccines of the future? |
| cord-297131-3a9vjpvn | Why are pharmaceutical companies gradually abandoning vaccines? |
| cord-297960-4x1j0iqg | : can we ever expect the unexpected? |
| cord-297960-4x1j0iqg | How Do intrinsically disordered viral proteins hijack the cell? |
| cord-295445-f4p00yaw | Chlorine: is it really so bad and what are the alternatives? |
| cord-295445-f4p00yaw | I. Collection of virus samples Oncogenic papillomavirus and polyomavirus in water environments: is there a potential for waterborne transmission? |
| cord-302486-z36hcvrx | Negative staining method for high resolution electron microscopy of viruses Detection of prions in blood Multiplex realtime quantitative RT- PCR assay for hepatitis B virus, hepatitis C virus, and human immunodeficiency virus type 1 DNA microarrays of the complex human cytomegalovirus genome: profiling kinetic class with drug sensitivity of viral gene expression A role for arrays in clinical virology: fact or fiction? |
| cord-298905-c2uuvfm5 | Is phosphatidyl- serine a VSV- binding site? |
| cord-298905-c2uuvfm5 | the acetylcholine receptor a rabies virus receptor? |
| cord-298051-ej8qxkce | How is DNA amplification monitored in real time during qPCR? |
| cord-298051-ej8qxkce | What about viruses with an RNA genome? |
| cord-294812-nnlzwaf1 | The aetiology of tuberculosis( translation of Die Aetiologie der Tuberculose( 1882) Sequence- based identification of microbial pathogens: a reconsideration of Koch's postulates The environment and disease: association or causation? |
| cord-294812-nnlzwaf1 | Viral infections in immunocompromised patients: what's new with respiratory viruses? |
| cord-294812-nnlzwaf1 | Viruses associated with pneumonia in adults Emerging respiratory agents: new viruses for old diseases? |
| cord-287851-9p0dr7rl | Anti- infl ammatory eff ects of pioglitazone and/or simvastatin in high cardiovascular risk patients with elevated high sensitivity C- reactive protein: the PIOSTAT Study Statin/ fi brate combination in patients with metabolic syndrome or diabetes: evaluating the risks of pharmacokinetic drug interactions Duration and intensity of NF- κB activity determine the severity of endotoxin- induced acute lung injury NFkappaB negatively regulates interferon- induced gene expressions and anti- infl uenza activity Eff ects of chloroquine on viral infections: an old drug against today's diseases? |
| cord-287851-9p0dr7rl | Can the same approach be used for pandemic treatment and prophylaxis? |
| cord-287851-9p0dr7rl | Confronting an influenza pandemic with inexpensive generic agents: can it be done? |
| cord-287851-9p0dr7rl | Is an eff ective"bottom up"approach using one or more widely available generic agents a realistic possibility? |
| cord-287851-9p0dr7rl | prospective cohort study Statin use and mortality in sepsis due to pneumonia Increased survival after gemfi brozil treatment of severe mouse infl uenza Peroxisome proliferator- activated receptors and acute lung injury Regulation of infl ammation by PPARs: a future approach to treat lung infl ammatory diseases? |
| cord-289593-81vu2kbu | Asthma and allergy patterns over 18 years after severe RSV bronchiolitis in the first year of life Determinants of asthma after severe respiratory syncytial virus bronchiolitis Risk of childhood asthma following infant bronchiolitis during the respiratory syncytial virus season Rhinovirus- induced wheezing in infancy- the first sign of childhood asthma? |
| cord-289593-81vu2kbu | In young children, persistent wheezing is associated with bronchial bacterial infection: a retrospective analysis Bacterial flora of the lower respiratory tract in children with bronchial asthma Bronchoalveolar cells in children< 3 years old with severe recurrent wheezing Investigation of young children with severe recurrent wheeze: any clinical benefit? |
| cord-289593-81vu2kbu | The outcome after severe bronchiolitis is related to gender and virus Virus infection and allergy in the development of asthma: what is the connection? |
| cord-289593-81vu2kbu | la colonisation par un certain type de bactéries, ou qui favoriserait l'asthme dès qu'une telle colonisation survient? |
| cord-289593-81vu2kbu | ou jouent- elles un rôle actif? |
| cord-298489-uqrzzh0e | A major epidemic of chikungunya virus infection on Réunion Island Chikungunya: A potentially emerging epidemic? |
| cord-298489-uqrzzh0e | So how did the virus originally emerge and cause human disease? |
| cord-300837-d0a8y5qh | ephrin- B2 A neutralization test for specific detection of Nipah virus antibodies using pseudotyped vesicular stomatitis virus expressing green fluorescent protein Retrovirus vectors: toward the plentivirus? |
| cord-300837-d0a8y5qh | paramyxovirus F Enveloped viruses: a common mode of membrane fusion? |
| cord-304807-j2k1oel2 | Inactivated or damaged? |
| cord-296819-gztmidn2 | Detection of JEV RNA sequences in birds collected in Italy Retrospective screening of serum and cerebrospinal fluid samples from patients with acute meningo- encephalitis does not reveal past Japanese encephalitis virus infection Tick- borne encephalitis( TBE) trends in epidemiology and current and future management Yellow fever and dengue: a threat to Europe? |
| cord-296819-gztmidn2 | Does the Japanese encephalitis virus( JEV) represent a threat for human health in Europe? |
| cord-296819-gztmidn2 | First international proficiency study on West Nile virus molecular detection Second external quality assessment of the molecular diagnostic of West Nile virus: are there improvements towards the detection of WNV? |
| cord-255217-l2ak5ygj | At what range of temperatures are common respiratory viruses sensitive? |
| cord-255217-l2ak5ygj | At what range of temperatures are common respiratory viruses sensitive? |
| cord-255217-l2ak5ygj | What is it that makes respiratory viruses such successful parasites of the human airway? |
| cord-255217-l2ak5ygj | What is it that makes respiratory viruses such successful parasites of the human airway? |
| cord-255217-l2ak5ygj | What is the mechanism for their temperature sensitivity? |
| cord-255217-l2ak5ygj | What is the mechanism for their temperature sensitivity? |
| cord-255217-l2ak5ygj | What is the range of temperature along the human airway? |
| cord-255217-l2ak5ygj | What is the range of temperature along the human airway? |
| cord-255217-l2ak5ygj | What is the role of temperature sensitivity in respiratory zoonoses? |
| cord-255217-l2ak5ygj | What is the role of temperature sensitivity in respiratory zoonoses? |
| cord-255217-l2ak5ygj | What is viral temperature sensitivity? |
| cord-255217-l2ak5ygj | What is viral temperature sensitivity? |
| cord-255217-l2ak5ygj | Why is temperature sensitivity important for the success of common respiratory viruses? |
| cord-255217-l2ak5ygj | their role in transmission of respiratory viral infections, including SARS- CoV-2 Transmission routes of respiratory viruses among humans Asymptomatic spread of flu is not proved Does influenza transmission occur from asymptomatic infection or prior to symptom onset? |
| cord-299379-ch7a39d6 | Application of immunofluorescence Prevalence and seasonal distribution of respiratory viruses during the 2014- 2015 season in Istanbul Respiratory virus infection in infants and children Does respiratory virus coinfection increases the clinical severity of acute respiratory infection among children infected with respiratory syncytial virus? |
| cord-299379-ch7a39d6 | Ten years( 2004- 2014) of influenza surveillance in Northern Italy Multipathogen infections in hospitalized children with acute respiratory infections Causative agents of severe community acquired viral pneumonia among children in Eastern Thailand Concurrent serious bacterial infections in 912 infants and children hospitalized for treatment of respiratory syncytial virus lower respiratory tract infection Human bocavirus: passenger or pathogen in acute respiratory tract infections? |
| cord-303186-2hxlx1j2 | Distinct characteristics and complex evolution of PEDV strains US- like strain of porcine epidemic diarrhea virus outbreaks in Taiwan Molecular characterization of pig epidemic diarrhoea viruses isolated in Japan from Antibody responses in serum, colostrum, and milk of swine after infection or vaccination with transmissible gastroenteritis virus Lactogenic immunity and vaccines for porcine epidemic diarrhea virus( PEDV): historical and current concepts Does circulating antibody play a role in the protection of piglets against porcine epidemic diarrhea virus? |
| cord-301064-ex6qb6zj | Where do all these manuscripts get published? |
| cord-301064-ex6qb6zj | Why? |
| cord-300810-a1skdp67 | 55, 158-l 62 Is the acetylcholine receptor a rabies virus receptor? |
| cord-300810-a1skdp67 | Why are certain neurons not permissive for AvOl? |
| cord-300133-yc2wxgid | , Guinea Does this patient have Ebola virus disease? |
| cord-300133-yc2wxgid | virus, virus antigen, and IgG and IgM antibody findings among EHF patients in Kikwit, Democratic Republic of the Congo Diagnosis of Ebola haemorrhagic fever by RT- PCR in an epidemic setting Rapid diagnosis of Ebola hemorrhagic fever by reverse transcription- PCR in an outbreak setting and assessment of patient viral load as a predictor of outcome Laboratory diagnosis of Ebola and Marburg hemorrhagic fever Guidance for collection, transport, and submission of specimens for Ebola virus testing in the United States Extreme PCR: a breakthrough innovation for outbreaks? |
| cord-304850-9xetsc2c | What links bats to emerging infectious diseases? |
| cord-276616-odmnvv7m | A more direct immunological approach would be to look for antibody to other disease entities; for example, with what frequency are antibodies to BLV encountered in cattle in cases of BSE? |
| cord-276616-odmnvv7m | Could vaccination against infection with this virus have increased the susceptibility to scrapie? |
| cord-276616-odmnvv7m | For instance, can the material of which prions are a component( SAF) act as a viral promoter of other neurotropic viruses? |
| cord-276616-odmnvv7m | Is Spiroplasma mirum, proposed as a possible cause of scrapie, merely a passenger responding to a suppressed immune state in the same way as Pneumocystis carini in patients with AIDS( Redfield and Burke, 1988)? |
| cord-276616-odmnvv7m | Is such triggering of a quiescent virus possible? |
| cord-276616-odmnvv7m | Scrapie agent proteins do not accumulate in grey tumour mice Purification of scrapie agents: how far have we come? |
| cord-276616-odmnvv7m | The response in mice to heat treated scrapie agent Assay of ethane and pentane from isolated organs and cells Basis of hepatitis delta virus disease? |
| cord-276616-odmnvv7m | with what frequency are maedi- visna antibodies encountered in sheep with scrapie? |
| cord-301362-f3lp10lm | The molecular pathogenesis of Semliki Forest virus: a model virus made useful? |
| cord-299786-wuve0tjz | Human skin Langerhans cells are targets of dengue virus infection Dengue haemorrhagic fever and dengue shock syndrome: Are they tumour necrosis factor- mediated disorders? |
| cord-299786-wuve0tjz | I major histocompatibility complex antigens on infected cells Phenotypic changes in Langerhans'cells after infection with arboviruses: A role in the immune response to epidermally acquired viral infection? |
| cord-305263-fgwf6wy3 | alpha-2a with or without ribavirin for HBeAg- negative chronic hepatitis B Increasing proportion of herpes simplex virus type I as a cause of genital herpes infection in college students Herpes simplex virus encephalitis: new infection or reactivation? |
| cord-306983-6w2fvtfy | Influenza A virus associated with acute encephalopathy PCR on cerebrospinal fluid to show influenza- associated acute encephalopathy or encephalitis Systemic cytokine responses in patients with influenza- associated encephalopathy Induction of proinflammatory cytokines in human macrophages by influenza A( H5N1) viruses: a mechanism for the unusual severity of human disease? |
| cord-277641-nb1p1akx | Cabinet Who cares for the'low- skilled'care worker? |
| cord-277641-nb1p1akx | Could our enemy's enemy be our friend? |
| cord-277641-nb1p1akx | Did we really need to drive so much, and fly so much, and shop so much for things that do n't really matter? |
| cord-277641-nb1p1akx | Do we really even need to earn at all? |
| cord-277641-nb1p1akx | Do we really need to earn so much? |
| cord-277641-nb1p1akx | How can we ensure that the lessons we have quickly learned from coronavirus are not forgotten? |
| cord-277641-nb1p1akx | Why do we need to go into the office if( as has turned out to be true for very many) we can work from home? |
| cord-277641-nb1p1akx | Why do we spend hours commuting every day to work when that means we see so little of our families? |
| cord-023488-jf2xl3vl | : can we ever expect the unexpected? |
| cord-023488-jf2xl3vl | And when did HIV spread from the first human cases to become a global plague? |
| cord-023488-jf2xl3vl | Are camels the main source of human infections? |
| cord-023488-jf2xl3vl | From an epidemiological viewpoint, why did this outbreak of Ebola explode into a massive pandemic, in contrast to the many prior outbreaks that were limited to no more than a few hundred cases at most? |
| cord-023488-jf2xl3vl | How do camels become infected? |
| cord-023488-jf2xl3vl | Is computer modeling a useful adjunct to the analysis or control of emerging viral diseases? |
| cord-023488-jf2xl3vl | Is this an evolving outbreak, and if so, what is driving it? |
| cord-023488-jf2xl3vl | The emergence of HIV may be divided into two phases: What was the zoonotic source of HIV and when did it cross into humans? |
| cord-023488-jf2xl3vl | The first question that confronts the investigator faced with a disease of unknown etiology is whether or not it has an infectious etiology? |
| cord-023488-jf2xl3vl | What has caused this disease to emerge in 2012, or had it preexisted but was just recognized at that time? |
| cord-023488-jf2xl3vl | What is the origin of this new disease? |
| cord-023488-jf2xl3vl | Where did it come from? |
| cord-023488-jf2xl3vl | Where will it end? |
| cord-023488-jf2xl3vl | Why did it cause a pandemic? |
| cord-023488-jf2xl3vl | Why did the international health community fail to control it? |
| cord-023488-jf2xl3vl | Why then did poliomyelitis emerge abruptly as an epidemic disease? |
| cord-295873-kykyubdq | Does viral interference affect spread of influenza? |
| cord-295873-kykyubdq | Respiratory viral infection in infants: causes, clinical symptoms, virology, and immunology Frequency of viruses associated with acute respiratory infections in children younger than five years of age at a locality of Mexico City Wheezy babies- wheezy adults? |
| cord-295873-kykyubdq | lower respiratory disease Phylogenetic analysis reveals the global migration of seasonal influenza A viruses Do rhinoviruses reduce the probability of viral co- detection during acute respiratory tract infections? |
| cord-295640-mhfu0e9r | Besides, M2e specific cellular immune response may stimulate CD4? |
| cord-295640-mhfu0e9r | Healthy human subjects have CD4? |
| cord-295640-mhfu0e9r | However, it may protect animals against challenge by ADCC, antibody- dependent cellular phagocytosis, or antibody- dependent complement deposition, and NP cellular immune response may stimulate CD4? |
| cord-295640-mhfu0e9r | and CD8? |
| cord-305302-go87uu06 | How can we define such emerging entities? |
| cord-306733-df36w6l7 | What Does Plant- Based Vaccine Technology Offer to the Fight against COVID-19? |
| cord-309048-emmtplv3 | So what have plant viruses ever done for virology and molecular biology? |
| cord-308385-bcph664h | What's going on with the diamond princess? |
| cord-290385-0smnl70i | A new threat looming over the Mediterranean basin: emergence of viral diseases transmitted by Aedes albopictus mosquitoes Dengue and dengue vectors in the WHO European region: past, present, and scenarios for the future Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia Probable non- vector- borne transmission of Zika virus Potential sexual transmission of Zika virus Evidence of perinatal transmission of Zika virus, French Polynesia Detection of Zika virus in saliva Dengue infection in pregnancy: prevalence, vertical transmission, and pregnancy outcome Maternal dengue and pregnancy outcomes: a systematic review Maternal and fetal consequences of dengue fever during pregnancy Maternal and perinatal outcomes of dengue in PortSudan, Eastern Sudan Breast milk as a possible route of vertical transmission of dengue virus? |
| cord-290385-0smnl70i | The emergence of influenza A H7N9 in human beings 16 years after influenza A H5N1: a tale of two cities Emergence in China of human disease due to avian influenza A(H10N8) e cause for concern? |
| cord-290385-0smnl70i | Two years after pandemic influenza A/2009/ H1N1: what have we learned? |
| cord-290385-0smnl70i | intrauterine infection causes fetal brain abnormality and microcephaly: tip of the iceberg? |
| cord-290385-0smnl70i | pii: S0037e86822015005003102 El Niño and climate change- contributing factors in the dispersal of Zika virus in the Americas? |
| cord-290385-0smnl70i | the beginning of another SARS- like pandemic? |
| cord-307817-2vy28i4m | Pyridinone derivatives: specific human immunodeficiency virus type 1 reverse transcriptase inhibitors with antiviral activity Structure- activity relationship studies on clinically relevant HIV-1 NNRTIs Non- nucleoside inhibitors of the HCV NS5B polymerase: progress in the discovery and development of novel agents for the treatment of HCV infections Next- generation integrase inhibitors: where to after raltegravir? |
| cord-283756-ycjzitlk | An Updated Review Focusing on the Pteropid Reservoir and Features of Transmission A real pandemic threat? |
| cord-283756-ycjzitlk | Are bats special? |
| cord-283756-ycjzitlk | For example, are older juvenile bats and non- breeding adult bats more likely to range further in migration( and hence spread disease to other hosts) than younger juveniles or the breeding adults, or to be caught by bushmeat hunters( as they are less experienced in survival)? |
| cord-283756-ycjzitlk | The Distribution of Henipaviruses in Southeast Asia and Australasia: Is Wallace's Line a Barrier to Nipah Virus? |
| cord-283756-ycjzitlk | The scale of illegal meat importation from Africa to Europe via Paris Frozen porcupines and bats confiscated in Paris exotic food raid Zoonotic Disease Risk and the Bushmeat Trade: Assessing Awareness Among Hunters and Traders in Sierra Leone Is that a rodent in your luggage? |
| cord-283756-ycjzitlk | Vector Borne and Zoonotic Dis Short report: Detection of Nipah virus RNA in fruit bat( Pteropus giganteus) from India Antibodies to Nipah or Nipah- like Viruses in Bats Henipavirus- related Sequences in Fruit Bat Bushmeat Co- circulation of diverse paramyxoviruses in an urban African fruit bat population Henipavirus and Tioman virus antibodies in pteropodid bats Continent- wide panmixia of an African fruit bat facilitates transmission of potentially zoonotic viruses Marburg Virus Infection Detected in a Common African Bat Isolation of Genetically Diverse Marburg Viruses from Egyptian Fruit Bats Seasonal Pulses of Marburg Virus Circulation in Juvenile Rousettus aegyptiacus Bats Coincide with Periods of Increased Risk of Human Infection Large serological survey showing cocirculation of Ebola and Marburg viruses in Gabonese bat populations, and a high seroprevalence of both viruses in Rousettus aegyptiacus Is Marburg Virus Enzootic in Gabon? |
| cord-305488-vk59ghjm | Avian paramyxovirus serotype-1: a review of disease distribution, clinical symptoms, and laboratory diagnostics Newcastle disease virus outbreaks: vaccine mismatch or inadequate application? |
| cord-305742-wf6qxplf | What is Life? |
| cord-304481-yqc8r3ll | A comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special? |
| cord-304481-yqc8r3ll | What links bats to emerging infectious diseases? |
| cord-309120-05bg7rfa | medRxiv Mechanistic insights into the effect 861 of humidity on airborne influenza virus survival, transmission and incidence Environmental sampling for respiratory pathogens in Jeddah airport during the 2013 Hajj 865 season Deviations in influenza seasonality: odd coincidence or 868 obscure consequence? |
| cord-305165-3twlnkac | New porcine coronavirus? |
| cord-304569-o39kl5k4 | A H10N8--a virus on the verge? |
| cord-017008-c7skxte0 | : what is the relationship? |
| cord-017008-c7skxte0 | And more importantly, what was the rate of transmission between hosts? |
| cord-017008-c7skxte0 | Both ecological and functional perspectives on host- pathogens ’ interactions are required to answer the opening question but also to devise appropriate health- care measures in order to prevent( and predict?) |
| cord-017008-c7skxte0 | But what aspects of his work exactly are evolutionary or Darwinian? |
| cord-017008-c7skxte0 | Despite the( crucial) facts that antibiotics were available during the second two pandemics, and that medical care had signifi cantly improved and was more effi cient after 1950, this raises the question: why was the 1918- 19 pandemic so deadly to humans? |
| cord-017008-c7skxte0 | Did the 1918- 19 infl uenza pandemic originate in China? |
| cord-017008-c7skxte0 | Enhanced virulence of infl uenza A viruses with the haemagglutinin of the 1918 pandemic virus? |
| cord-017008-c7skxte0 | For instance, how close were the troops? |
| cord-017008-c7skxte0 | How likely is it that this genetic information be used for harmful purposes? |
| cord-017008-c7skxte0 | How many soldiers were there? |
| cord-017008-c7skxte0 | In sum, both ecological and functional perspectives on host- pathogens'interactions are required to answer the opening question of this essay but also to devise appropriate health- care measures in order to prevent( and predict?) |
| cord-017008-c7skxte0 | In: The threat of pandemic infl uenza: are we ready? |
| cord-017008-c7skxte0 | Is Mayr's proximate- ultimate dichotomy still useful? |
| cord-017008-c7skxte0 | Should n't host and pathogens 2 peacefully coevolve, and thus maximize both their chances of survival, instead of engaging in a near- infi nite arms race? |
| cord-017008-c7skxte0 | So why was the Spanish infl uenza so devastating? |
| cord-017008-c7skxte0 | The question"why do parasites harm their hosts?"is recurrent in evolutionary biology and ecology, and has several implications for the medical sciences, particularly public health and epidemiology. |
| cord-017008-c7skxte0 | What if someone with nefarious intentions reconstructs the virus? |
| cord-017008-c7skxte0 | What if, by accident or not, the virus escapes into the environment? |
| cord-017008-c7skxte0 | What is a pathogen? |
| cord-017008-c7skxte0 | Why do parasites harm their hosts? |
| cord-017008-c7skxte0 | “ Why do parasites harm their host? ” is a recurrent question in evolutionary biology and ecology, and has several implications for the biomedical sciences, particularly public health and epidemiology. |
| cord-309489-ubf55eux | Polio: The Final Assault? |
| cord-291063-de7v4e5s | Are viral- encoded microRNAs mediating latent HIV-1 infection? |
| cord-291063-de7v4e5s | LNA- mediated microRNA silencing in non- human primates Oligonucleotide antiviral therapeutics: antisense and RNA interference for highly pathogenic RNA viruses Silencing of microRNAs in vivo with'antagomirs Specificity, duplex degradation and subcellular localization of antagomirs Regulation of microRNA by antagomirs: a new class of pharmacological antagonists for the specific regulation of gene function? |
| cord-291063-de7v4e5s | Silencing Viral MicroRNA as a Novel Antiviral Therapy? |
| cord-291063-de7v4e5s | The properties and functions of virus encoded microRNA, siRNA, and other small noncoding RNAs Small RNAs: delivering the future Lentivirusmediated antagomir expression for specific inhibition of miRNA function Antisense, RNAi, and gene silencing strategies for therapy: mission possible or impossible? |
| cord-291063-de7v4e5s | ammunition to target miRNAs implicated in human disease? |
| cord-291946-kq0rsuxj | : Can we ever expect the unexpected? |
| cord-291946-kq0rsuxj | But where do they come from? |
| cord-291946-kq0rsuxj | How then did this mammalian retrovirus get into birds? |
| cord-291946-kq0rsuxj | Thus, the answer to the question''where did these viruses come from?''will increasingly become''they came from ancient forms of other viruses,''although in some cases, such as those described for REV[ 21], they come through a thoroughly circuitous route. |
| cord-291946-kq0rsuxj | Ultimately, though, where did these viruses come from? |
| cord-292286-ygomb3oi | Computational screen and experimental validation of anti- influenza effects of quercetin and chlorogenic acid from traditional Chinese medicine Molecular docking of potential inhibitors for influenza H7N9 Quercetin: bioflavonoids as part of interferon- free hepatitis C therapy? |
| cord-292286-ygomb3oi | Further studies indicated that baicalin can directly induce IFN- c production in human CD4? |
| cord-292286-ygomb3oi | T cells and CD8? |
| cord-292286-ygomb3oi | The green tea catechin, epigallocatechin gallate inhibits Chikungunya virus infection Colonic metabolites of berry polyphenols: the missing link to biological activity? |
| cord-292286-ygomb3oi | show anti- Mayaro virus activity Effects of baicalein on Sendai virus in vivo are linked to serum baicalin and its inhibition of hemagglutinin- neuraminidase Chitosan nanoparticles enhance the intestinal absorption of the green tea catechins(?) |
| cord-290133-4ou7ubb4 | Even if it can remain aerosolized and viable for a prolonged period of time, just how infectious is it by this route? |
| cord-290133-4ou7ubb4 | If it can be aerosolized, for how long does it remain viable, and how far can it be carried? |
| cord-290133-4ou7ubb4 | In vitro activity of potential anti- poxvirus agents Expression of mouse interleukin-4 by a recombinant ectromelia virus suppresses cytolytic lymphocyte responses and overcomes genetic resistance to mousepox Smallpox: anything to declare? |
| cord-290133-4ou7ubb4 | Is the N95 respirator appropriate for occupational protection against SARS? |
| cord-290133-4ou7ubb4 | The case for voluntary smallpox vaccination Smallpox and smallpox vaccination The 1972 smallpox outbreak in Khulna Municipality, Bangladesh Can postexposure vaccination against smallpox succeed? |
| cord-290133-4ou7ubb4 | The questions are these:( 1) Can smallpox virus be aerosolized? |
| cord-290481-i2ppvsh5 | What could be the reason for multiplication of diverse suppressors in closteroviruses as opposed to single suppressors of smaller viruses? |
| cord-290481-i2ppvsh5 | What is the driving force behind the increase in viral genome complexity? |
| cord-290481-i2ppvsh5 | What is the functional significance of the increase in genome complexity seen in closteroviruses relative to the simpler plant viruses? |
| cord-290481-i2ppvsh5 | What would be considered an'environmental catastrophe'for a virus? |
| cord-290481-i2ppvsh5 | Why then the largest DNA viruses with the ∼1200 kb genomes are so much larger than the largest RNA viruses with the ∼30 kb genomes? |
| cord-290481-i2ppvsh5 | a titanic achievement? |
| cord-290540-r0d6oaez | How do FIP- inducing coronaviruses arise? |
| cord-290540-r0d6oaez | One important question is: do we really want to protect against the FIPV infection? |
| cord-290540-r0d6oaez | So who is the enemy? |
| cord-290540-r0d6oaez | What are the correlates of protection? |
| cord-290540-r0d6oaez | What is the origin of the coronaviruses causing FIP? |
| cord-290540-r0d6oaez | What is the origin of the serotype II, what is the molecular basis for the serotypes? |
| cord-309179-5hlatbqe | A large infantile gastroenteritis outbreak in Albania caused by multiple emerging rotavirus genotypes Are waterborne astrovirus implicated in acute digestive morbidity( E.MI.R.A. study)? |
| cord-300435-vs0ntcsb | Are viruses driving microbial diversification and diversity? |
| cord-300435-vs0ntcsb | The ϕ6 cystovirus protein P7 becomes accessible to antibodies in the transcribing nucleocapsid: a probe for viral structural elements An epidemiologic study of the relationship between hepatitis A and water supply characteristics and treatment Disassembly of the cystovirus ϕ6 envelope by montmorillonite clay Montmorillonite- mediated aggregation induces deformation of influenza virus particles Here a virus, there a virus, everywhere the same virus? |
| cord-298678-hjxph9jm | An outbreak of viral gastroenteritis associated with consumption of sandwiches: implications for the control of transmission by food handlers Food- borne outbreaks of hepatitis A in a low endemic country: an emerging problem? |
| cord-298678-hjxph9jm | an age- and sex- matched case- control study Norwalk virus: how infectious is it? |
| cord-298678-hjxph9jm | the link between food and patient investigations in an international context Review: norovirus prevalence in Belgian, Canadian and French fresh produce: a threat to human health? |
| cord-295433-olmein3q | A comparison of bats and rodents as reservoirs of zoonotic viruses: Are bats special? |
| cord-295433-olmein3q | Bats and zoonotic viruses: Can we confidently link bats with emerging deadly viruses? |
| cord-295433-olmein3q | Further Evidence for Bats as the Evolutionary Source of Middle East Respiratory Syndrome Coronavirus Middle East respiratory syndrome( MERS): Bats or dromedary, which of them is responsible? |
| cord-295433-olmein3q | How do these viruses modulate the numerous host responses in bats and how does that affect virus replication? |
| cord-258389-1u05w7r4 | Are cells obtained directly from organs and tissues in primary cell culture? |
| cord-258389-1u05w7r4 | Do stem cells can not differentiate into other kinds of cells? |
| cord-258389-1u05w7r4 | Does passage effect leads to an increase in the virulence of cultured viruses? |
| cord-258389-1u05w7r4 | Drugs must be tested, manufactured? |
| cord-258389-1u05w7r4 | Is Bevacizumab approved for the treatment of colorectal cancer? |
| cord-258389-1u05w7r4 | Is IFN- α used for the treatment of multiple sclerosis? |
| cord-258389-1u05w7r4 | Is identity testing a way to determine purity of culture? |
| cord-258389-1u05w7r4 | Is secondary culture used for studying transformed cells? |
| cord-258389-1u05w7r4 | Is the VLP- based HPV vaccine approved by the FDA? |
| cord-258389-1u05w7r4 | Living cells are used in organ- on- a- chip microfluidic cell culture Can embryonic cells be cultured without any feeder layer? |
| cord-258389-1u05w7r4 | Serum is one of the basic components of cell culture media( true/ false)? |
| cord-258389-1u05w7r4 | What are the different phases of the growth curve? |
| cord-258389-1u05w7r4 | What is the Hayflick effect? |
| cord-258389-1u05w7r4 | What is the source of cells for primary monolayer cell culture? |
| cord-258389-1u05w7r4 | What was the first recombinant human protein? |
| cord-309067-aemjbkfj | Is the genetic region that is targeted highly conserved or heterologous among isolates? |
| cord-307899-427a7i3h | To control atrophic rhinitis, avirulent live, or inactivated organisms alone or in combination with P. multocida, Erysipelothrix rhusiopathiae and!? |
| cord-309381-cb80ntxs | The annual impact of seasonal influenza in the US: Measuring disease burden and costs The continual threat of influenza virus infections at the human- animal interface: What is new from a one health perspective? |
| cord-298733-jole21wq | But how did it come to pass that there was a Common Cold Unit at all, and was it really a good idea to have one? |
| cord-298733-jole21wq | Was it really a good idea? |
| cord-298733-jole21wq | Was it worth it? |
| cord-298733-jole21wq | Would research have gone on equally well without it? |
| cord-296309-i1mpov7k | 3 Control for stochastic sampling variation and qualitative sequencing error in next generation sequencing Tales from the crypt and coral reef: the successes and challenges of identifying new herpesviruses using metagenomics Human cancers and mammalian retroviruses: should we worry about bovine leukemia virus? |
| cord-296309-i1mpov7k | We will discuss the strengths, weaknesses and technical challenges of different viral WGS methods Why sequence whole genomes? |
| cord-296309-i1mpov7k | What does the future hold? |
| cord-296309-i1mpov7k | Why do we need deep sequencing? |
| cord-296309-i1mpov7k | benefit health now Clinical management of HIV-1 resistance HIV-1 genotypic drug resistance testing: digging deep, reaching wide? |
| cord-302277-c66xm2n4 | An overview of the molecular mechanisms by which bacteria interact with one another to construct complex multispecies biofilms Phylogeny of Porphyromonas gingivalis by ribosomal intergenic spacer region analysis Association of Bacteroides forsythus and a novel Bacteroides phylotype with periodontitis Diversity of bacterial populations on the tongue dorsa of patients with halitosis and healthy patients Prevalence of bacteria of division TM7 in human subgingival plaque and their association with disease Single- cell enumeration of an uncultivated TM7 subgroup in the human subgingival crevice Genetic relatedness and phenotypic characteristics of Treponema associated with human periodontal tissues and ruminant foot disease New bacterial species associated with chronic periodontitis Beyond the specific plaque hypothesis: are highly leukotoxic strains of Actinobacillus actinomycetemcomitans a paradigm for periodontal pathogenesis? |
| cord-302277-c66xm2n4 | Contemporaneous and successive mixed Plasmodium falciparum and Plasmodium vivax infections are associated with Ascaris lumbricoides: an immunomodulating effect? |
| cord-302277-c66xm2n4 | Herpesviruses: a unifying causative factor in periodontitis? |
| cord-302277-c66xm2n4 | how big a risk? |
| cord-309635-1tgovkr7 | How can neuraminidase- based immunity contribute to better influenza virus vaccines? |
| cord-311748-yr2ep7uf | Microbiological Risk Assessment Series Development of a multiplex bead- based assay for detection of hepatitis C virus Nested multiplex PCR assay for detection of human enteric viruses in shellfi sh and sewage Nanotechnologies for pathogen detection: Future alternatives? |
| cord-310942-191m0e65 | Russel J. title: Beneficial actions of melatonin in the management of viral infections: a new use for this “ molecular handyman ”? |
| cord-307364-j86t65qu | Nidovirus transcription: how to make sense …? |
| cord-304251-dohglrm1 | -a reality in near future? |
| cord-304251-dohglrm1 | : a singlecenter series of 67 patients and review of clinical outcome and trends Chikungunya: a potentially emerging epidemic? |
| cord-304251-dohglrm1 | Viruses: are they really culprits for periodontal disease? |
| cord-302055-s155i4e9 | What do physicians and other clinicians need to do? |
| cord-302055-s155i4e9 | Where can one obtain the most reliable advice? |
| cord-302055-s155i4e9 | s155i4e9 nan W hat do we know about this virus? |
| cord-302047-vv5gpldi | : What Have we Learned? |
| cord-302047-vv5gpldi | First, how stable are natural virus genomes, and under what conditions do they become unstable? |
| cord-302047-vv5gpldi | Second, since horizontal gene transfer( HGT) plays an important role in virus evolution, under what conditions are transferred sequences likely to be retained? |
| cord-295041-5vpawtef | ( SARS- CoV-2) Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host- virus interaction, and proposed neurotropic mechanisms Can the enteric nervous system be an alternative entrance door in SARS- CoV2 neuroinvasion? |
| cord-295041-5vpawtef | A mechanism of virus- induced demyelination Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system? |
| cord-295041-5vpawtef | COVID-19 in a MS patient treated with ocrelizumab: does immunosuppression have a protective role? |
| cord-295041-5vpawtef | How Covid-19 can damage the brain Neurological manifestations in severe acute respiratory syndrome Guillain- Barré syndrome associated with SARS- CoV-2 infection: causality or coincidence? |
| cord-295041-5vpawtef | More Prevalent Than Acknowledged? |
| cord-295041-5vpawtef | causative or coincidental? |
| cord-310171-1fmsxx2s | in Australian cystic fibrosis patients: identification of novel risk factors? |
| cord-277400-w7mvk3x4 | It was not detected in any other viral family beside Leviviridae( and only in 0.26% eukaryotic proteomes) and thus could be used to characterize Leviviruses( Leviviridae- like lineage? |
| cord-277400-w7mvk3x4 | Ninth Report of the International Committee on Taxonomy of Viruses Origins and evolution of viruses of eukaryotes: the ultimate modularity The ancient Virus World and evolution of cells Virus evolution: how far does the double beta- barrel viral lineage extend? |
| cord-277400-w7mvk3x4 | Second, only a qualitative assessment of viral diversity( e.g., whether retrotranscribing viruses are likely to be present in samples or not?) seems possible utilizing capsid as taxonomic marker. |
| cord-277400-w7mvk3x4 | Structural comparison of the plant satellite viruses National center for biotechnology information viral genomes project Crystal structure of the top domain of African horse sickness virus VP7: comparisons with bluetongue virus VP7 Does common architecture reveal a viral lineage spanning all three domains of life? |
| cord-277400-w7mvk3x4 | Therefore, more work is required to establish if the capsids from retrotranscribing viruses form independent lineages or just one( i.e., Retrotranscribing- like lineage?). |
| cord-277400-w7mvk3x4 | Together, the major and minor coat proteins( negligible presence in cellular proteomes, Table 1) can perhaps characterize inoviruses( i.e., Inovirus- like lineage?). |
| cord-277400-w7mvk3x4 | What does structure tell us about virus evolution? |
| cord-277400-w7mvk3x4 | new developments Distant mimivirus relative with a larger genome highlights the fundamental features of Megaviridae Common ancestry of herpesviruses and tailed DNA bacteriophages Expression of animal virus genomes Do viruses form lineages across different domains of life? |
| cord-277400-w7mvk3x4 | the concept of the viral'self,"'in Emerging Topics in Physical Virology Structure unifies the viral universe Are viruses a source of new protein folds for organisms? |
| cord-286298-pn9nwl64 | : What is the role of radiologists? |
| cord-286298-pn9nwl64 | Are aerosol, saliva, feces, urine, and foodborne the only routes of transmission? |
| cord-286298-pn9nwl64 | Can Chinese medicine be used for prevention of corona virus disease 2019( COVID-19)? |
| cord-286298-pn9nwl64 | Could Intravenous Immunoglobulin Collected from Recovered Coronavirus Patients Protect against COVID-19 and Strengthen the Immune System of New Patients? |
| cord-286298-pn9nwl64 | These unresolved questions include: What is the origin of SARS- CoV-2? |
| cord-286298-pn9nwl64 | What are the other unknown routes of transmission? |
| cord-286298-pn9nwl64 | What is the intermediate host that transmitted the virus from bats? |
| cord-286298-pn9nwl64 | Why does the virus cause severe disease and mortality in the elderly or those with co- morbidities, while it is milder in children? |
| cord-286298-pn9nwl64 | interferon signals in lung stromal cells protect from influenza virus infection Rescue fecal microbiota transplantation for antibiotic- associated diarrhea in critically ill patients Long- Term safety and efficacy of fecal microbiota transplant in active ulcerative colitis Microbiota and its role on viral evasion: Is it with us or against us? |
| cord-310870-w8wu8vno | Test method and requirements Similarities and differences in the responses of microorganisms to biocides Is hepatitis B- virucidal validation of biocides possible with the use of surrogates? |
| cord-315346-ebfjba4y | Is Routine Patient Care an Aerosol Generating Procedure? |
| cord-310439-z0bxsjug | The control of African cassava mosaic virus disease: Phytosanitation and/or resistance? |
| cord-316245-n6tmn4ph | role of polymerase chain reaction and demonstration of multiple infections Comparison of nasopharyngeal flocked swabs and nasopharyngeal wash collection methods for respiratory virus detection in hospitalized children using real- time polymerase chain reaction Evidence from multiplex molecular assays for complex multipathogen interactions in acute respiratory infections Are meteorological parameters associated with acute respiratory tract infections? |
| cord-311382-ioemd0ij | What was the primary mode of smallpox transmission? |
| cord-310795-n78s0sg2 | a three- year prospective study Do rhinoviruses reduce the probability of viral co- detection during acute respiratory tract infections? |
| cord-311823-85wj08gr | Does the converse hold true for a virus such as HCV, which typically establishes a persistent infection characterized by mild( or slowly progressing) disease? |
| cord-311823-85wj08gr | How then can greater benefits be gained from using functional genomics to study virus- host interactions? |
| cord-313301-7mkadtp9 | Recurrent mutations associated with isolation and passage of SARS coronavirus in cells from non- human primates Mechanisms of avian retrovial host range extension Deletion mutations of the genome segments of wound tumor virus Speciation via habitat selection: the evolution of reproductive isolation as a correlated character Laboratory experiments on speciation: what have we learned in 40 years? |
| cord-312332-rwmuucsp | Do cellular RBPs participate in viral particle assembly? |
| cord-307046-ko3bdvo0 | -Where do you draw the line? |
| cord-307046-ko3bdvo0 | Does this number reflect the true diversity of viruses circulating in the vast territory of northern Eurasia? |
| cord-307046-ko3bdvo0 | alongside viruses for which we have a viable isolate? |
| cord-317198-mean7sj9 | What is the role of respiratory viruses in community acquired pneumonia; what is the best therapy for influenza and other viral causes of CAP? |
| cord-312688-12san3m7 | The virion glycoproteins of Ebola viruses are encoded in two reading frames and are expressed through transcriptional editing Effects of chloroquine on viral infections: an old drug against today's diseases? |
| cord-307813-elom30nx | A decoy peptide that disrupts TIRAP recruitment to TLRs is protective in a murine model of influenza Novel strategies for targeting innate immune responses to influenza Highly pathogenic avian influenza A H5N1 and pandemic H1N1 virus infections have different phenotypes in toll- like receptor 3 knockout mice Inhibition of toll- like receptor signaling as a promising therapy for inflammatory diseases: a journey from molecular to nano therapeutics Small- molecule inhibitors of the TLR3/ dsRNA complex Radix isatidis polysaccharides inhibit influenza a virus and influenza A virus- induced inflammation via suppression of Host TLR3 signaling in vitro Novel effect of methionine enkephalin against influenza A virus infection through inhibiting TLR7-MyD88-TRAF6-NF- kappaB p65 signaling pathway Influenza virus and glycemic variability in diabetes: a killer combination? |
| cord-307813-elom30nx | Innate lymphoid cells in asthma: will they take your breath away? |
| cord-307813-elom30nx | a mechanism for the unusual severity of human disease? |
| cord-315131-4yb2b70g | The KDEL retrieval system is exploited by Pseudomonas exotoxin A, but not by Shiga- like toxin-1, during retrograde transport from the Golgi complex to the endoplasmic reticulum Facing inward from compartment shores: How many pathways were we looking for? |
| cord-309346-4mdxe6ri | Does this patient have influenza? |
| cord-309346-4mdxe6ri | Investigating such a lot Of illnesses which no one's got, When everybody, young and old, Is frantic with the common cold? |
| cord-309346-4mdxe6ri | Sabemos tratar el catarro común? |
| cord-315167-ph15z424 | passenger or pathogen in acute respiratory tract infections? |
| cord-314254-9ye8tfvz | A strategy to estimate unknown viral diversity in mammals Virology: the virus whose family expanded Bats and viruses: friend or foe? |
| cord-314254-9ye8tfvz | Evolving epidemiology of hepatitis C virus Hepatitis C and liver transplantation Novel therapies for hepatitis C- one pill fits all? |
| cord-310141-2jofy8fo | Antiviral RNAi therapy: emerging approaches for hitting a moving target Nucleic acids- based therapeutics in the battle against pathogenic viruses RNAi: the nuts and bolts of the RISC machine RNA interference: new mechanisms for targeted treatment? |
| cord-310141-2jofy8fo | how many mechanisms? |
| cord-310141-2jofy8fo | nude mice Filoviridae: a taxonomic home for Marburg and Ebola viruses? |
| cord-314190-fvdock94 | Is nasal suctioning warranted before measuring O 2 saturation in infants with bronchiolitis? |
| cord-314190-fvdock94 | are they internally valid, reliable and predictive of oxygen use in children with acute bronchiolitis? |
| cord-304343-m7tbdfri | FIP200, a counterpart of yeast Atg17? |
| cord-304343-m7tbdfri | Lipid starvation or indigestion? |
| cord-304343-m7tbdfri | Quantitative proteomics identifies ncoa4 as the cargo receptor mediating ferritinophagy Role of autophagy in a model of obesity: A long- term high fat diet induces cardiac dysfunction Is autophagy associated with diabetes mellitus and its complications? |
| cord-304343-m7tbdfri | What do we really know in vivo? |
| cord-295792-hajvtzj9 | Are all children well protected from acquiring the infection or only from the risk of becoming ill after being infected? |
| cord-295792-hajvtzj9 | Assuming that children as secondary cases become infected in second, third or even fourth order after the initial case, would their clinical manifestations be more attenuated? |
| cord-295792-hajvtzj9 | COVID-19 infection: the perspectives on immune responses Are children less susceptible to COVID19? |
| cord-295792-hajvtzj9 | Can melatonin reduce the severity of COVID-19 pandemic? |
| cord-295792-hajvtzj9 | Considering this state of cell differentiation in childhood and that the distribution of ACE2 receptors is uneven in different organs and populations, are there differences in the extent and function of ACE2 in the alveolar tissue of children and adults? |
| cord-295792-hajvtzj9 | So what is the chance of transmission of active virus from the respiratory tract of the child? |
| cord-295792-hajvtzj9 | The impact of pneumococcal vaccination on bacterial and viral Pneumonia in western australian children: Record Linkage Cohort Study of 469589 Births Does pneumococcal vaccine reduce influenza morbidity in humans? |
| cord-309642-wwaa6ls0 | Some aspects of pulmonary defence Retroviral transforming genes in normal cells? |
| cord-309642-wwaa6ls0 | The immunopathogenesis of dengue haemorrhagic fever Virally induced alterations in cellular permeability: A basis of cellular and physiological damage? |
| cord-303533-6s01qplg | Does nidovirus RNA synthesis take place anywhere except inside DMVs? |
| cord-303533-6s01qplg | How do viral and host proteins interact as replicative organelles are formed? |
| cord-303533-6s01qplg | What are the differences in protein composition and conformation in spherules, convoluted membranes, and DMVs? |
| cord-303533-6s01qplg | What happens to the RNA that accumulates inside DMVs? |
| cord-303533-6s01qplg | key: cord-303533- 6s01qplg authors: Neuman, Benjamin W.; Angelini, Megan M.; Buchmeier, Michael J. title: Does form meet function in the coronavirus replicative organelle? |
| cord-315037-lmur80te | Are we ready for novel detection methods to treat respiratory pathogens in hospital- acquired pneumonia? |
| cord-315037-lmur80te | Benefits for infection control and bed management Viral respiratory tract infections in allogeneic hematopoietic stem cell transplantation recipients in the era of molecular testing The use of antimicrobial agents after diagnosis of viral respiratory tract infections in hospitalized adults: Antibiotics or anxiolytics? |
| cord-297790-tpjxt0w5 | A comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special? |
| cord-297790-tpjxt0w5 | A molecular phylogeny for bats illuminates biogeography and the fossil record Host and viral traits predict zoonotic spillover from mammals Are disease reservoirs special? |
| cord-297790-tpjxt0w5 | Are bats exceptional viral reservoirs? |
| cord-297790-tpjxt0w5 | Do our life history traits make us susceptible to generating damaging immune responses to RNA viruses or does the physiology of bats make them particularly tolerant or resistant? |
| cord-297790-tpjxt0w5 | Mass extinctions, biodiversity and mitochondrial function: are bats'special'as reservoirs for emerging viruses? |
| cord-297790-tpjxt0w5 | What links bats to emerging infectious diseases? |
| cord-287711-gw8mgg4m | ( 2004) illustrated the ability of Al 3? |
| cord-287711-gw8mgg4m | (, 2007a proposed a variation in the method that consisted in pre- conditioning the filter with Al 3? ions. |
| cord-287711-gw8mgg4m | Despite these promising data, the two viradel methods based on electronegative filters( i.e., addition of MgCl 2 to water samples or filter coating with Al 3? |
| cord-287711-gw8mgg4m | Hence, most tests reported so far for virus concentration from water samples using cellulose ester filters( essentially HA filters) have been performed after addition of multivalent cations( mainly Mg 2?) to the water samples with or without pH adjustment to an acidic level. |
| cord-287711-gw8mgg4m | Self assembled into nanosheets to yield''mille feuille''structures, they showed efficient removal of parvoviruses( Gustafsson et al. 2016b): maybe a new filtration media for viral clearance? |
| cord-287711-gw8mgg4m | The presence of salts enhanced virus adsorption to cellulose ester membranes, this effect increasing with the cation valence( i.e., Al 3? |
| cord-287711-gw8mgg4m | The triple layered A1HC filter media from EMD Millipore include two depth filtration layers( cellulose? diatomaceous earth) of different grades and a 0.1 lm- pore- size microporous membrane pre- filter made of mixed cellulose esters( van Reis and Zydney 2007). |
| cord-287711-gw8mgg4m | [ Mg 2? |
| cord-287711-gw8mgg4m | [ Na?) |
| cord-287711-gw8mgg4m | n95 or surgical masks? |
| cord-317851-lj07947c | What properties make RNA viruses excellent models for experimental evolution? |
| cord-308201-lavcsqov | A reconsideration of Koch's postulates The Environment and Disease: Association or Causation? |
| cord-308201-lavcsqov | New respiratory viral infections Emerging respiratory agents: New viruses for old diseases? |
| cord-308201-lavcsqov | What's new with respiratory viruses? |
| cord-308201-lavcsqov | authors: Desforges, Marc; Le Coupanec, Alain; Dubeau, Philippe; Bourgouin, Andréanne; Lajoie, Louise; Dubé, Mathieu; Talbot, Pierre J. title: Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? |
| cord-316996-8yimrpaz | Microbiol Microbial sialidases: does bigger always mean better? |
| cord-316996-8yimrpaz | The human Cas1 protein: a sialic acid- specific Oacetyltransferase? |
| cord-291534-c6cjxq07 | A potential issue with using defensins as a topical antiviral treatment is that, despite CHDPs( including defensins) being required for in vitro anti- HIV activity of vaginal fluid from healthy women, defensins may also cause immune activation and subsequent loss of CD4? |
| cord-291534-c6cjxq07 | Both down- regulate the co- receptor CXCR4 expression( but not CCR5) on the surface of CD4? |
| cord-291534-c6cjxq07 | Gene structure and developmental expression Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract Neisseria gonorrhoeae- induced human defensins 5 and 6 increase HIV infectivity: role in enhanced transmission Paneth cell defensins: endogenous peptide components of intestinal host defense Mouse neutrophils lack defensins Strain- specific polymorphisms in Paneth cell alpha- defensins of C57BL/6 mice and evidence of vestigial myeloid alpha- defensin pseudogenes Antibacterial activity and specificity of the six human{ alpha}-defensins Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? |
| cord-291534-c6cjxq07 | In addition b- defensins are described as having a range of immunomodulatory properties, including chemotaxis of CD4? |
| cord-291534-c6cjxq07 | Initial studies on retrocyclins found no direct inactivation of HIV-1, but demonstrated strong inhibition of proviral DNA formation and protection of primary human CD4? |
| cord-291534-c6cjxq07 | LL-37 has been shown to inhibit the replication of a range of HIV-1 isolates in primary CD4? |
| cord-291534-c6cjxq07 | Of these, RC100 was found to inhibit primary CD4? |
| cord-291534-c6cjxq07 | a- Defensins have been demonstrated to directly inactivate HIV-1, with the observation of reduced cytopathogenicity in a CD4? |
| cord-291534-c6cjxq07 | dendritic and T cell CCR6 Human beta- defensin-3 promotes wound healing in infected diabetic wounds beta- Defensins: multifunctional modulators of infection, inflammation and more? |
| cord-319210-yqimufdh | Does a retrovirally encoded superantigen cause multiple sclerosis? |
| cord-317244-4su5on6s | Bat white- nose syndrome: an emerging fungal pathogen? |
| cord-317244-4su5on6s | Is Marburg Virus Enzootic in Gabon? |
| cord-301592-n5ns3m34 | : is it such a big deal anymore? |
| cord-301592-n5ns3m34 | Aetiology of acute pharyngitis: the role of atypical bacteria Febrile exudative tonsillitis: viral or streptococcal? |
| cord-301592-n5ns3m34 | Are empiric antibiotics for acute exudative tonsillitis needed in children? |
| cord-301592-n5ns3m34 | Latent species C adenoviruses in human tonsil tissues Are procalcitonin or other infection markers useful in the detection of group A streptococcal acute tonsillitis? |
| cord-301592-n5ns3m34 | What is the added benefit of oropharyngeal swabs compared to nasal swabs alone for respiratory virus detection in hospitalized children aged< 10 years? |
| cord-021966-5m21bsrw | > Having chosen an antigen and presentation system, what is the best way to produce it on a large scale? |
| cord-021966-5m21bsrw | A review of the Vaccine Adverse Event Reporting System database Vaccine safety surveillance using large linked databases: opportunities, hazards and proposed guidelines Permanent brain damage and pertussis vaccination: is the end of the saga in sight? |
| cord-021966-5m21bsrw | Can a specific antigen( or antigens) be identified that represents the target of protective host immune responses? |
| cord-021966-5m21bsrw | Can the pathogen be grown in culture? |
| cord-021966-5m21bsrw | Even larger phase IIb studies can provide additional data on vaccine safety and immunogenicity in subjects generally representative of those for whom the vaccine might be recommended, but importantly, also provide the first opportunity to address to answer the question,'Does this vaccine work in humans?' |
| cord-021966-5m21bsrw | If natural immunity capable of preventing re- infection follows an initial infection with the pathogen, can a specific host immune effector mechanism( e.g., antibody, CD8 T- cell) be identified as the likely agent( or'correlate') of immune protection? |
| cord-021966-5m21bsrw | If so, can a threshold level of this specific immune correlate needed for protection from re- infection be defined? |
| cord-021966-5m21bsrw | If so, does the pathogen cause such a life- threatening disease that an attenuated version of the virus would face an impossible barrier for demonstration of safety? |
| cord-021966-5m21bsrw | If the infection occurs relatively rarely in an overall population, can a subset of the population be identified that has a higher risk of infection so as to accelerate the achievement of statistically significant protection? |
| cord-021966-5m21bsrw | If the protective immune response is mediated by antibodies, can the target antigen( be it a protein or polysaccharide) be produced in scalable quantities in a form that mimics its native structure so that it can effectively elicit antibody responses that can block the key functional role(s) of the target molecule in the pathogen lifecycle or otherwise lead to the clearance of an incipient pathogen infection? |
| cord-021966-5m21bsrw | Is immunity to a given antigen associated with protection against disease following re- exposure in the context of natural infection? |
| cord-021966-5m21bsrw | Is the antigen of interest sufficiently immunogenic on its own, or is augmentation of the desired immune response by conjugation to a specific carrier or addition of an adjuvant necessary to elicit a sufficient and sufficiently durable immune response in individuals in the target population for vaccination? |
| cord-021966-5m21bsrw | Is this subset sufficiently similar to the rest of the population to enable extrapolation of the clinical results to the broader target population as a whole? |
| cord-021966-5m21bsrw | Recent advances in the development of HIV-1 vaccines using replication- incompetent adenovirus vectors One step forward, two steps back-will there ever be an AIDS vaccine? |
| cord-021966-5m21bsrw | The MMR vaccination and autism controversy in United Kingdom 1998- 2005: inevitable community outrage or a failure of risk communication? |
| cord-021966-5m21bsrw | What are the major unmet medical and public health needs today? |
| cord-021966-5m21bsrw | What is known about the natural history and pathogenic mechanisms of the infection of interest? |
| cord-021966-5m21bsrw | What is the attack rate of the infection in the general population? |
| cord-021966-5m21bsrw | What is the most effective way to present the antigens of the pathogen of interest to the immune system? |
| cord-021966-5m21bsrw | What tests to evaluate vaccine immunogenicity will need to carried out on clinical samples obtained from participants in the clinical trials? |
| cord-021966-5m21bsrw | What types of potential safety concerns can be anticipated for the vaccine in question? |
| cord-021966-5m21bsrw | Will measurement of antibody titers, T- cell responses, pathogen presence and quantity, pathogen serotype, and any other parameter peculiar to the disease in question represent the primary criteria for vaccine effect? |
| cord-321053-lgae22f8 | Novel therapies for hepatitis C-one pill fits all? |
| cord-320693-de1lmzl1 | : do they have a future as therapeutics? |
| cord-316273-vo6j8zb0 | In vivo evolution of HIV-1 co- receptor usage and sensitivity to chemokine- mediated suppression Inhibition of VSV binding and infectivity by phosphatidylserine: is phosphatidylserine a VSV- binding site? |
| cord-316273-vo6j8zb0 | the Ebola virus glycoprotein Conserved structural features in the interaction between retroviral surface and transmembrane glycoproteins? |
| cord-320055-6ycp8m89 | Questions to be answered, with regard to estuarine and marine water standards include:( i) for which activities are water quality standards needed;( ii) are corresponding fresh water indicators adequate and appropriate indicators of health hazards or increased risk of disease arising from the presence of pathogenic organisms of fecal origin; and( iii) are such indicators appropriate and satisfactory, even for fresh water? |
| cord-323333-keshu99t | Ensuring the pathogen safety of intravenous immunoglobulin and other human plasma- derived therapeutic proteins Production of intravenous immunoglobulin and other plasma- derived products: focus on pathogen safety Quality control of IgG preparations by protein analysis Autoimmunity and immunotherapy Three generations of immunoglobulin G preparations for clinical use Viral safety issues in IGIV products Human prion diseases Memory, synaptic translation, and... prions? |
| cord-303297-fiievwy7 | COVID-19 patients after successful treatment or recovery again become severely infected with other strains of this virus? |
| cord-303297-fiievwy7 | Even though the exact origin of the virus remains unclear, it is possible to infect a Chinese horseshoe bat or a pangolin with the SARS- CoV-2 and evaluate the success of the infection to determine the origin of the new virus responsible for the pandemic: did it come from animals or from a laboratory? |
| cord-303297-fiievwy7 | However, is it in our power to do so when the official number of diagnosed cases has already exceeded 1 million people worldwide? |
| cord-303297-fiievwy7 | Is it important today to stop the spread of infection as quickly as possible? |
| cord-303297-fiievwy7 | What about reinfection with other possible strains of people who recovered from initial infection with one strain? |
| cord-303297-fiievwy7 | What about reinfection? |
| cord-317277-rr9zue4l | They might be giants: does syncytium formation sink or spread HIV infection? |
| cord-317277-rr9zue4l | Viral extracellular biofilms: a novel spreading trick of viruses? |
| cord-323009-frej2qmb | What are the implications for childhood pneumonia of successfully introducing Hib and pneumococcal vaccines in developing countries Childhood pneumonia- progress and challenges Epidemiological and clinical study of viral respiratory tract infections in children from Italy Occurrence of respiratory virus: time, place and person Respiratory viral infections in infants: causes, clinical symptoms, virology, and immunology Influenza in Africa Epidemiological and virological influenza survey in Dakar Pandemic A(H1N1)2009 influenza virus detection by real time RT- PCR: is viral quantification useful? |
| cord-321741-aq76s37x | JNJ872 inhibits influenza A virus replication without altering cellular antiviral responses Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota- independent manner T7 RNA polymerase- dependent and-independent systems for cDNA- based rescue of Rift Valley fever virus Animal models of Chikungunya virus infection and disease Emerging virus diseases: can we ever expect the unexpected? |
| cord-324775-3x5os79m | Risk of respiratory syncytial virus infection for infants from low- income families in relationship to age, sex, ethnic group, and maternal antibody level Viral infections in relation to age, atrophy, and season of admission among children hospitalized for wheezing Parainfluenza viruses What have we learned from the Tucson Children's Respiratory Study? |
| cord-322904-9mta0aem | How do animal DNA viruses get to the nucleus? |
| cord-323404-3mw4q7m3 | strain A59 is released from opposite sides of different epithelial cell types Antigenic and molecular analyses reveal that the equine rotavirus strain H-1 is closely related to porcine, but not equine, rotaviruses: interspecies transmission from pigs to horses? |
| cord-304747-ojyxs3cp | At what age does infection typically occur? |
| cord-304747-ojyxs3cp | If so, what kind of disease does it cause? |
| cord-304747-ojyxs3cp | SV40 small t antigen enhances the transformation activity of limiting concentrations of SV40 large T antigen Creation of human tumour cells with defined genetic elements Is there a role for SV40 in human cancer? |
| cord-304747-ojyxs3cp | This discovery raises many questions for further investigation, such as, Is WU virus a human pathogen? |
| cord-304747-ojyxs3cp | Where in the body does WU virus reside? |
| cord-319754-5isw53wl | An Essential"Receptor"or an"Accessory Attachment Factor"for Hepatitis A Virus? PIP5K- driven PtdIns(4,5)P2 synthesis: Regulation and cellular functions Function and dysfunction of the PI system in membrane trafficking PIP2: Choreographer of actin- adaptor proteins in the HIV-1 dance Synchronized HIV assembly by tunable PIP2 changes reveals PIP2 requirement for stable Gag anchoring Quantification of phosphoinositides reveals strong enrichment of PIP2 in HIV-1 compared to producer cell membranes Investigation of the Lipid Binding Properties of the Marburg Virus Matrix Protein VP40 Type I phosphatidylinositol-4-phosphate |
| cord-319754-5isw53wl | Signaling Multifaceted roles for lipids in viral infection Ultrastructure of the replication sites of positive- strand RNA viruses Does form meet function in the coronavirus replicative organelle? |
| cord-310255-aixq5mhf | : Are there ways to improve its productivity? |
| cord-310255-aixq5mhf | Can an FDA- approved Alzheimer's drug be repurposed for alleviating neuronal symptoms of zika virus? |
| cord-310255-aixq5mhf | Structures and functions beyond cell membrane permeabilization Emerging roles of viroporins encoded by DNA viruses: Novel targets for antivirals? |
| cord-310255-aixq5mhf | Viral dependence on cellular ion channels- An emerging antiviral target? |
| cord-318551-c1qr27lg | The nucleolus- a gateway to viral infection? |
| cord-318551-c1qr27lg | What then might be the most appropriate strategy to unambiguously distinguish between factors involved in replication and/or transcription but not in translation, between( À) and( þ) strand RNA synthesis, and between those directly involved in a given mechanism and those that affect this mechanism indirectly? |
| cord-299207-lw0cv74b | A pandemic warning? |
| cord-299207-lw0cv74b | Are ducks contributing to the endemicity of highly pathogenic H5N1 influenza virus in Asia? |
| cord-299207-lw0cv74b | How do these factors affect the transmission? |
| cord-299207-lw0cv74b | However, how to determine the possible number of outbreaks per day denoted by K(n)? |
| cord-299207-lw0cv74b | WHO Protective cross- reactive cellular immunity to lethal A/ Goose/ Guangdong/1/96-like H5N1 influenza virus is correlated with the proportion of pulmonary CD8+ T cells expressing gamma interferon Cross- reactive, cell- mediated immunity and protection of chickens from lethal H5N1 influenza virus infection in Hong Kong poultry markets Pandemic influenza: a zoonosis? |
| cord-299207-lw0cv74b | Why do we need R in our model? |
| cord-317619-o7qfugjw | Herpes simplex virus from respiratory tract secretions: epidemiology, clinical characteristics, and outcome in immunocompromised and nonimmunocompromised hosts Life- threatening human herpes virus-6 infection in early childhood: presenting symptom of a primary immunodeficiency? |
| cord-317619-o7qfugjw | Herpes simplex virus type 1 and respiratory disease in critically- ill patients: real pathogen or innocent bystander? |
| cord-325280-4whzcmqv | what's the future holding for us? |
| cord-323700-5awng7h1 | A novel duplex real- time PCR for HPIV-4 detects co- circulation of both viral subtypes among ill children during Real- time quantitative PCR assays for detection and monitoring of pathogenic human viruses in immunosuppressed pediatric patients Rapid detection of herpes simplex virus and varicella- zoster virus infections by real- time PCR A 5'-nuclease real- time reverse transcriptase- polymerase chain reaction assay for the detection of a broad range of influenza A subtypes, including H5N1 Is chronic rhinosinusitis caused by persistent respiratory virus infection? |
| cord-325875-93krp81r | These specimens offer new possibilities for surveillance, but are they diagnostically equivalent? |
| cord-317501-yblzopc3 | Is Mycobacterium tuberculosis a closer relative to Gram- positive or Gram- negative bacterial pathogens? |
| cord-317501-yblzopc3 | The production of a genus- specific recombinant antibody( scFv) using a recombinant potyvirus protease Identification of a putative Crf splice variant and generation of recombinant antibodies for the specific detection of Aspergillus fumigatus Construction of human antibody gene libraries and selection of antibodies by phage display Highthroughput screening of single- chain antibodies using multiplexed flow cytometry Generating recombinant antibodies to the complete human proteome High level transient production of recombinant antibodies and antibody fusion proteins in HEK293 cells Recombinant human monoclonal antibodies to Ebola virus Making antibodies by phage display technology Which are the antibodies to watch in 2013? |
| cord-317501-yblzopc3 | The therapeutic monoclonal antibody market Highaffinity, human antibody- like antibody fragment( singlechain variable fragment) neutralizing the lethal factor( LF) of Bacillus anthracis by inhibiting protective antigen- LF complex formation Tumor necrosis factor alpha drugs in rheumatoid arthritis: systematic review and metaanalysis of efficacy and safety Anti- epidermal growth factor receptor monotherapy in the treatment of metastatic colorectal cancer: where are we today? |
| cord-308857-otsrexqu | A major question remains open to date,"how can the symptoms of COVID-19 be detected in their early stages? |
| cord-308857-otsrexqu | A more specific question is whether ultra- violet( UV) light can kill coronavirus? |
| cord-308857-otsrexqu | COVID-19: A new digital dawn? |
| cord-308857-otsrexqu | Will 10 million people die a year due to antimicrobial resistance by 2050? |
| cord-308857-otsrexqu | [ 104] asked"Will 10 million people die a year due to AMR by 2050? |
| cord-325635-don9qjpz | Refugees A community- based study of acute respiratory tract infection in Thai children Influenza pandemic plans: what about displaced populations? |
| cord-318686-we6pveus | A comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special? |
| cord-318686-we6pveus | Bat airway epithelial cells: a novel tool for the study of zoonotic viruses More novel hantaviruses and diversifying reservoir hosts- time for development of reservoir- derived cell culture models? |
| cord-312461-5qzpo6l1 | At what stage of illness are rescue oxygenation devices warranted? |
| cord-312461-5qzpo6l1 | For example, what adjunctive therapies are useful? |
| cord-312461-5qzpo6l1 | The pathogenic potential of a microbe Exserohilum rostratum fungal meningitis associated with methylprednisolone injections Microbial threat lists: obstacles in the quest for biosecurity? |
| cord-312461-5qzpo6l1 | What coinfections may be present? |
| cord-321835-qn33sx8x | Pyramidal and extrapyramidal involvement in experimental infection of cynomolgus monkeys with enterovirus 71 Enterovirus 71 infection and vaccines Isolation of a cytopathogenic agent from human adenoids undergoing spontaneous degeneration in tissue culture Outbreak of febrile respiratory illness caused by adenovirus at a south Korean military training facility: clinical and radiological characteristics of adenovirus pneumonia Adenovirus vaccines Human adenovirus type 7 outbreak in police training center Dramatic decline of respiratory illness among US military recruits after the renewed use of adenovirus vaccines Acute respiratory disease associated with adenovirus serotype 14-four states Severe pneumonia due to adenovirus serotype 14: a new respiratory threat? |
| cord-321835-qn33sx8x | Types of Influenza Viruses Influenza A(H3N2) virus in swine at agricultural fairs and transmission to humans Are people living near modern swine production facilities at increased risk of influenza virus infection? |
| cord-325230-3kg4oe4g | another mechanism for host protein synthesis shutoff? |
| cord-322082-80ym2rsq | How can neuraminidase- based immunity contribute to better influenza virus vaccines? |
| cord-322082-80ym2rsq | influenza viruses circulating in humans What is a pandemic? |
| cord-298745-3rrlap70 | So what precipitated their emergence? |
| cord-298745-3rrlap70 | What are the potential impacts on humans and domestic species? |
| cord-298745-3rrlap70 | What are the spillover mechanisms? |
| cord-298745-3rrlap70 | What factors precipitated their emergence? |
| cord-298745-3rrlap70 | What is their geographic occurrence? |
| cord-298745-3rrlap70 | Why did they emerge at this time? |
| cord-298745-3rrlap70 | beyond their natural ecological niche, precipitating their emergence? |
| cord-323195-buzcb8ya | Can we distinguish respiratory viral infections based on clinical features? |
| cord-323195-buzcb8ya | Time to revisit infection control strategies? |
| cord-327199-ggomuomb | HECT ubiquitin ligases link viral and cellular PPXY motifs to the vacuolar protein- sorting pathway Visualization of intracellular transport of vesicular stomatitis virus nucleocapsids in living cells Mechanisms for enveloped virus budding: can some viruses do without an ESCRT? |
| cord-324984-ojrpsdt9 | , in patients infected with HIV-1 Chemokine control of West Nile virus infection Virological and immunological response to antiretroviral regimens containing maraviroc in HIV type 1-infected patients in clinical practice: role of different tropism testing results and of concomitant treatments Intensification of a raltegravir- based regimen with maraviroc in early HIV-1 infection Maraviroc and reverse transcriptase inhibitors combinations as potential preexposure prophylaxis candidates( S)-methyl-1-piperazinyl]-4-methylpiperidine( Sch-417690/ Sch- D), a potent, highly selective, and orally bioavailable CCR5 antagonist Pharmacokinetics and short- term safety of 873140, a novel CCR5 antagonist, in healthy adult subjects An imidazopiperidine series of CCR5 antagonists for the treatment of HIV: the discovery of N-{(1S)-1-(3-Fluorophenyl)-3-[(3-endo)-3-(5-isobutyryl-2-methyl-4,5,6,7-tetrahydro-1H- imidazo[4, 5-c]pyridin-1-yl)-8-azabicyclo[3.2.1]oct-8-yl]propyl}acetamide( PF-232798) Is PF-232798 a possible successor to maraviroc? |
| cord-324984-ojrpsdt9 | molecular chaperone inhibitors: are we there yet? |
| cord-323793-c69joaqs | Can graphene take part in the fight against COVID-19? |
| cord-323793-c69joaqs | So what happens when a graphene surface comes in contact with viruses? |
| cord-320015-lbr2q4qh | Characterization of primary and memory CD8 T- cell responses against ranavirus( FV3) in Xenopus laevis Xenopus laevis: A possible vector of Ranavirus infection? |
| cord-320015-lbr2q4qh | a purine nucleoside phosphorylase Genomic sequence of a ranavirus( family Iridoviridae) associated with salamander mortalities in North America Poxviruses: past, present, and future How similar are poxviruses? |
| cord-327855-txryqil7 | involvement of RNase L, protein kinase R, and alternative pathways Activation of NF- κB by double- stranded RNA( dsRNA) in the absence of protein kinase R and RNase L demonstrates the existence of two separate dsRNA triggered antiviral programs Membrane permeability induced by hepatitis A virus proteins 2B and 2BC and proteolytic processing of HAV 2BC Replication of hepatitis A viruses with chimeric 5 nontranslated regions Cleavage of poly( A)-binding protein by coxsackievirus 2A protease in vitro and in vivo: another mechanism for host protein synthesis shutoff? |
| cord-324950-ux7shvji | : over 100 M website views per year Ready to submit your research? |
| cord-324950-ux7shvji | Why, when and how should exposure be considered at the within- host scale? |
| cord-325611-tu1bn4hu | Bellamya chinensis Cyclovirus in nasopharyngeal aspirates of Chilean children with respiratory infections Is there still room for novel viral pathogens in pediatric respiratory tract infections? |
| cord-327777-pg98zc6o | A fast and effective stochastic algorithm for estimating maximum- likelihood phylogenies Persistent infections support maintenance of a coronavirus in a population of Australian bats( Myotis macropus) Persistence and evolution of feline coronavirus in a closed cat- breeding colony Hibernation: The immune system at rest? |
| cord-307744-wbr84taq | Did the son get a more virulent selection of virus after it passed through his mother, who was an older and weaker host? |
| cord-307744-wbr84taq | Does a younger host make the virus weaker? |
| cord-307744-wbr84taq | How Do Virus- Mosquito Interactions Lead to Viral Emergence? |
| cord-307744-wbr84taq | In other words, if the infection was acquired from a younger person, could the illness be milder? |
| cord-307744-wbr84taq | In other words, would the mother and son have survived, had the direction of transmission been reversed? |
| cord-307744-wbr84taq | The question is, did the general practitioners receive a more virulent form of the SARS- CoV-2 virus from their older patients? |
| cord-324295-9c1zxjng | The next big threat to global health? |
| cord-324295-9c1zxjng | What is the potential impact of the Amazon wildfires on vector- borne and zoonotic emerging diseases? |
| cord-319379-qe56u93a | Chloroquine for the 2019 novel coronavirus SARSCoV-2? |
| cord-319379-qe56u93a | The species severe acute respiratory syndrome- related coronavirus: classifying 2019-nCoV and naming it SARS- CoV-2 Will novel virus go pandemic or be contained? |
| cord-319379-qe56u93a | identifies four small- molecule inhibitors of middle east respiratory syndrome coronavirus replication in cell culture Repurposing of clinically developed drugs for treatment of middle east respiratory syndrome coronavirus infection Drug repurposing for new, efficient, broad spectrum antivirals Drug repurposing strategies for COVID-19 In silico studies on therapeutic agents for COVID-19: Drug repurposing approach New concepts in antimalarial use and mode of action in dermatology Chloroquine and Hydroxychloroquine Toxicity, Stat Pearls Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases Effects of chloroquine on viral infections: an old drug against today's diseases? |
| cord-325969-9zhmmvdg | Two years after pandemic influenza A/2009/ H1N1: what have we learned? |
| cord-325969-9zhmmvdg | What role do viruses play in nosocomial pneumonia? |
| cord-320935-3n157yl4 | : what is its fate in urban water cycle and how can the water research community respond? |
| cord-320935-3n157yl4 | COVID-19: gastrointestinal manifestations and potential fecal- oral transmission Enteric involvement of coronaviruses: is faecal- oral transmission of SARS- CoV-2 possible? |
| cord-320935-3n157yl4 | Put a lid on it: are faecal bio- aerosols a route of transmission for SARS- CoV-2? |
| cord-277417-f71jwdzj | A meta- analysis of trends in prognostic markers of HIV disease progression and transmission Association between the rate of CD4+ T cell decrease and the year of human immunodeficeny virus( HIV) type 1 seroconversion among persons enrolled in the Swiss HIV cohort study Is HIV-1 evolving to a less virulent form in humans? |
| cord-277417-f71jwdzj | A phylogenomic analysis of Marek's disease virus reveals independent paths to virulence in Eurasia and North America Immunity promotes virulence evolution in a malaria model Has the rate of progression to AIDS changed in recent years? |
| cord-277417-f71jwdzj | Can Ebola virus evolve to be less virulent in humans? |
| cord-277417-f71jwdzj | Can we read the future from a tree? |
| cord-277417-f71jwdzj | Convergent evolution of lysozyme sequences? |
| cord-277417-f71jwdzj | Did Zika virus mutate to cause severe outbreaks? |
| cord-277417-f71jwdzj | Globalization, land use, and the invasion of West Nile virus H5N1 influenza: a protean pandemic threat Are we ready for pandemic influenza? |
| cord-277417-f71jwdzj | Is there any consistent association between host- jumping and virulence such that predictions can be made about how virulence might evolve following emergence? |
| cord-277417-f71jwdzj | The human immunodeficiency virus Italian seroconversion study Is the virulence of HIV changing? |
| cord-277417-f71jwdzj | This paper provides an overview of the theory that there is a trade- off between virulence and transmissibility, highlighting areas in which the theory has been challenged and extended over the past 20 years Adaptive virulence evolution: the good old fitness- based approach Virulence and transmissibility of pathogens: what is the relationship? |
| cord-277417-f71jwdzj | Virological factors that increase the transmissibility of emerging human viruses Coevolution of hosts and parasites Evolution in Health and Disease Challenging the trade- off model for the evolution of virulence: is virulence management feasible? |
| cord-277417-f71jwdzj | What level of virulence is optimized by natural selection and why? |
| cord-277417-f71jwdzj | Why do RNA viruses recombine? |
| cord-277417-f71jwdzj | Will a virus become more or less virulent in a new host? |
| cord-277417-f71jwdzj | why they are not jacks of all trades? |
| cord-330827-gu2mt6zp | -Are we there yet? |
| cord-312964-vsrqmmv7 | Are antibiotics indicated as initial treatment for children with acute otitis media? |
| cord-312964-vsrqmmv7 | As yet, the epidemiology of OM caused by vURI is not completely developed( eg, Which viruses are most important? |
| cord-312964-vsrqmmv7 | Does virus infect the ME mucosa?), and the specific target population for aggressive intervention is not well characterized. |
| cord-312964-vsrqmmv7 | What is the time lapse between infection, symptoms, and complications?), the mechanism underlying OM pathogenesis is not fully understood( eg, Are there specific chemical signals that can be modulated to preserve host defense but prevent OM? |
| cord-312964-vsrqmmv7 | What is the time lapse between infection, symptoms, and complications?), the mechanism underlying OM pathogenesis is not fully understood( eg, Are there specific chemical signals that can be modulated to preserve host defense but prevent OM? |
| cord-312964-vsrqmmv7 | What's new with common colds? |
| cord-313356-ninzeazy | Is COVID-19 Receiving ADE From Other Coronaviruses? |
| cord-313356-ninzeazy | What is the mean persistence of coronaviruses compared to SARS- CoV-2? |
| cord-313356-ninzeazy | What is the persistence of SARS- CoV-2 on surfaces? |
| cord-313356-ninzeazy | What lessons have we learned? |
| cord-313356-ninzeazy | What should we know and what could we do? |
| cord-311908-sgdq6j6x | A randomized, placebo- controlled, double- blind study Clinical viral infections and multiple sclerosis Effects of in¯uenza vaccination and in¯uenza illness on exacerbations in multiple sclerosis Analysis of the molecular basis of neuropathogenesis of RNA viruses in experimental animals: relevance for human disease? |
| cord-311908-sgdq6j6x | Mechanism of action Chemokines and chemokine receptors in CNS pathology Encephalitis after hepatitis B vaccinationÐRecurrent disseminated encephalitis or MS? |
| cord-311908-sgdq6j6x | Multiple sclerosis and childhood infections Serendipity and multiple sclerosis epidemiology Is sporadic MS caused by an infection of adolescence and early childhood? |
| cord-311908-sgdq6j6x | Russell WC Viral etiology of multiple sclerosis: where does the truth lie? |
| cord-311908-sgdq6j6x | apoptosis or necrosis? |
| cord-332165-31tbc31x | The three- dimensional structure of reovirus obtained by cryo- electron microscopy Structure of the reovirus core at 3.6? |
| cord-331584-z43ifmr3 | 367pp Are we ready for pandemic influenza H5N1? |
| cord-326960-9phlylce | H1N1 influenza: What have we learned? |
| cord-326960-9phlylce | vu all over again? |
| cord-330647-w1bpeqzg | Are health care workers protected? |
| cord-319933-yp9ofhi8 | * Viral shedding patterns of coronavirus in patients with probable severe acute respiratory syndrome SARS vaccines: where are we? |
| cord-319933-yp9ofhi8 | An unusual hantavirus outbreak in southern Argentina: person- to- person transmission? |
| cord-319933-yp9ofhi8 | Efficacy assessment of a cell- mediated immunity HIV-1 vaccine( the step study): a double- blind, randomised, placebo- controlled, test- of- concept trial Human papillomavirus in cervical cancer Human papillomavirus research: do we still need animal models? |
| cord-319933-yp9ofhi8 | Phenotypic changes in Langerhans'cells after infection with arboviruses: a role in the immune response to epidermally acquired viral infection? |
| cord-306424-gf0bglm0 | IFN- lambda( IFN-??) is expressed in a tissue- dependent fashion and primarily acts on epithelial cells in vivo Severe acute respiratory syndrome- related coronavirus is inhibited by interferon- alpha Interferon- beta and interferongamma synergistically inhibit the replication of severe acute respiratory syndrome- associated coronavirus( SARS- CoV) Evaluation of immunomodulators, interferons and known in vitro SARS- CoV inhibitors for inhibition of SARS- CoV replication in BALB/ c mice Single- dose intranasal administration with mDEF201 |
| cord-306424-gf0bglm0 | IFN- lambda( IFN-??) is expressed in a tissue- dependent fashion and primarily acts on epithelial cells in vivo Severe acute respiratory syndrome- related coronavirus is inhibited by interferon- alpha Interferon- beta and interferongamma synergistically inhibit the replication of severe acute respiratory syndrome- associated coronavirus( SARS- CoV) Evaluation of immunomodulators, interferons and known in vitro SARS- CoV inhibitors for inhibition of SARS- CoV replication in BALB/ c mice Single- dose intranasal administration with mDEF201 |
| cord-306424-gf0bglm0 | Membranous replication factories induced by plus- strand RNA viruses Does form meet function in the coronavirus replicative organelle? |
| cord-306424-gf0bglm0 | interferon induction Cardif is an adaptor protein in the RIG- I antiviral pathway and is targeted by hepatitis C virus Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF VISA is an adapter protein required for virus- triggered IFN-?.?. |
| cord-306424-gf0bglm0 | interferon induction Cardif is an adaptor protein in the RIG- I antiviral pathway and is targeted by hepatitis C virus Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF VISA is an adapter protein required for virus- triggered IFN-?.?. |
| cord-306424-gf0bglm0 | what and how? |
| cord-294323-mryiqmsw | Oseltamivir and zanamivir are recommended for all individuals with suspected or confirmed influenza requiring hospitalization and patients in high- risk groups, such as children under the age of two years, adults 65 years or older, pregnant women, immunosuppressed individuals, and?? |
| cord-294323-mryiqmsw | Oseltamivir and zanamivir are recommended for all individuals with suspected or confirmed influenza requiring hospitalization and patients in high- risk groups, such as children under the age of two years, adults 65 years or older, pregnant women, immunosuppressed individuals, and?? |
| cord-294323-mryiqmsw | The origin of the 1918 pandemic influenza virus: a continuing enigma Influenza: the mother of all pandemics Updating the accounts: global mortality of the 1918- 1920"Spanish"influenza pandemic Characterization of the 1918 influenza virus polymerase genes Is the gene pool of influenza viruses in shorebirds and gulls different from that in wild ducks? |
| cord-294323-mryiqmsw | Usually,?? |
| cord-294323-mryiqmsw | Usually,?? |
| cord-294323-mryiqmsw | antiviral?? |
| cord-294323-mryiqmsw | antiviral?? |
| cord-294323-mryiqmsw | women who have given birth within the previous two weeks??. |
| cord-294323-mryiqmsw | women who have given birth within the previous two weeks??. |
| cord-332457-gan10za0 | Fourth national climate assessment, volume II Influenza seasonality in the tropics and subtropicswhen to vaccinate? |
| cord-324696-htx0ul4o | Current opinion in virology Middle East respiratory syndrome coronavirus in bats, Saudi Arabia Bats as'special'reservoirs for emerging zoonotic pathogens Bats are a major natural reservoir for hepaciviruses and pegiviruses Bats and zoonotic viruses: can we confidently link bats with emerging deadly viruses? |
| cord-324696-htx0ul4o | Mass extinctions, biodiversity and mitochondrial function: are bats'special'as reservoirs for emerging viruses? |
| cord-324696-htx0ul4o | While the role of bats in IAV evolution is not yet known, recent evidence raises a primary question,"can bats support co- infection of avian and human IAVs?". |
| cord-334771-uy3s6443 | Epidemiology of Japanese encephalitis in India: national conference on Japanese encephalitis Jamshedpur fever Etiology of the 1965 epidemic of febrile illness in Nagpur city, Maharashtra state Isolation of Chandipura virus from the blood in acute encephalopathy syndrome Outbreak of killer brain disease in children: mystery or missed diagnosis? |
| cord-022348-w7z97wir | And if so, what is the virus adapting to? |
| cord-022348-w7z97wir | Are They Adapting or Merely Changing? |
| cord-022348-w7z97wir | But if it were non- linear? |
| cord-022348-w7z97wir | Can quasispecies define a transient molecular clock? |
| cord-022348-w7z97wir | Conservative perhaps, but is there any suggestion that viruses are more or less so than other replicons? |
| cord-022348-w7z97wir | Could symptomatic infections reflect bottleneck transmission of those fitter clones with asymptomatic( subclinical) infection representing fitness- compromised clones? |
| cord-022348-w7z97wir | Does the VP1 gene of foot- and- mouth disease virus behave as a molecular clock? |
| cord-022348-w7z97wir | For outbred populations, is it in fact virulence? |
| cord-022348-w7z97wir | Given the inevitability of mutation, is it possible that over the aeons natural selection has selected for proteins that are robust, those that are capable of absorbing endless substitutions? |
| cord-022348-w7z97wir | How are innate and adaptive immune responses coupled and how are they influenced by genetic polymorphisms? |
| cord-022348-w7z97wir | How good are viruses as machines? |
| cord-022348-w7z97wir | How many rounds of infection are necessary to fix mutations? |
| cord-022348-w7z97wir | Is not fourth best in any large population remarkable? |
| cord-022348-w7z97wir | Might this finding suggest that the optimum is actually away from mass production? |
| cord-022348-w7z97wir | Problems arise transposing it to the in vivo situation, notably: 9 First and foremost: how does one determine fitness in vivo? |
| cord-022348-w7z97wir | Should such measurements score intrahost viral titres or transmission probabilities from an index case? |
| cord-022348-w7z97wir | We come to the basic question- to what extent is genetic variation exploited by an RNAvirus, if at all? |
| cord-022348-w7z97wir | What fraction of amino acid residues is necessary for function? |
| cord-022348-w7z97wir | What is the value of n? |
| cord-022348-w7z97wir | What might a viral species be? |
| cord-022348-w7z97wir | While they are fit enough to survive, are they the best possible? |
| cord-022348-w7z97wir | Why do they mutate rapidly yet remain phenotypically stable? |
| cord-022348-w7z97wir | Why is the evolution of RNA viruses so conservative? |
| cord-022348-w7z97wir | Why is this? |
| cord-022348-w7z97wir | Yet is that correct? |
| cord-022348-w7z97wir | Yet who can remember the name of any Olympic athlete who came in fourth? |
| cord-305327-hayhbs5u | Are we prepared for the worst of these hypothetic pandemics abundantly illustrated in the cinema and unfortunately sometimes overwhelmed when reality goes beyond fiction? |
| cord-305327-hayhbs5u | Are we prepared for the worst? |
| cord-305327-hayhbs5u | Did we learn from the past epidemics? |
| cord-305327-hayhbs5u | Let us first honestly address the fundamental questions about epdimeics and preparedness: What did we learn from all the past epidemics, what will we remember in times of need? |
| cord-305327-hayhbs5u | Perhaps, in a shrinking global community, after too many Ebola virus disease outbreaks, we will learn and be prepared for future epidemic challenges? |
| cord-305327-hayhbs5u | The Rockefeller Foundation From the Ebola river to the Ebola virus disease pandemic: what have we learned? |
| cord-305327-hayhbs5u | The smallpox pandemic of Smallpox: 12,000 years from plagues to eradication: a dermatologic ailment shaping the face of society Strategies for mitigating an influenza pandemic Dengue, urbanization and globalization: the unholy trinity of the 21st century SARS: an emerging global microbial threat Predicting epidemic risk from past temporal contact data Ebola control: effect of asymptomatic infection and acquired immunity Shedding of Ebola virus in an asymptomatic pregnant woman Understanding the emergence of Ebola virus disease in sierra leone: stalking the virus in the threatening wake of emergence Perspectives on West Africa Ebola virus disease outbreak Aedes alpobictus and the world trade in used tires, 1988- 1995: the shape of things to come? |
| cord-315339-dcui85lw | : is it infectious? |
| cord-315339-dcui85lw | In vitro comparison of the biologic activities of monoclonal monomeric IgA, polymeric IgA, and secretory IgA Role of IgA versus IgG in the control of influenza viral infection in the murine respiratory tract Cytotoxic T lymphocyte memory: role in cross- protective immunity against influenza? |
| cord-315339-dcui85lw | N- trimethyl chitosan( TMC) nanoparticles loaded with influenza subunit antigen for intranasal vaccination: biological properties and immunogenicity in a mouse model Incidence of acute respiratory illnesses among enlisted service members during their first year of military service: did the 2011 resumption of adenovirus vaccination of basic trainees have an effect? |
| cord-315339-dcui85lw | The absence of enhanced disease with wild type respiratory syncytial virus infection occurring after receipt of live, attenuated, respiratory syncytial virus vaccines Orthomyxoviruses M cell- targeted DNA vaccination Pathogen recognition and development of particulate vaccines: does size matter? |
| cord-315339-dcui85lw | modified vaccinia virus Ankara expressing the spike glycoprotein of severe acute respiratory syndrome coronavirus induces protective neutralizing antibodies primarily targeting the receptor binding region Seasonal influenza infection and live vaccine prime for a response to the 2009 pandemic H1N1 vaccine Induction of proinflammatory cytokines in human macrophages by influenza A( H5N1) viruses: a mechanism for the unusual severity of human disease? |
| cord-314825-fzba05wn | 2009 outbreak on pig farm Evidence of reassortment of pandemic H1N1 influenza virus in swine in Argentina: Are we facing the expansion of potential epicenters of influenza emergence? |
| cord-314825-fzba05wn | An influenza epicentre? |
| cord-314825-fzba05wn | Human to pig transmission in Norway? |
| cord-314825-fzba05wn | influenza viruses from pigs: Antigenic drift or interspecies transmission? |
| cord-319208-jrxz59bb | Are lanyards a risk for nosocomial transmission of potentially pathogenic bacteria? |
| cord-319208-jrxz59bb | Nosocomial respiratory syncytial virus infections in children's wards How long do nosocomial pathogens persist on inanimate surfaces? |
| cord-319208-jrxz59bb | Pathogenic bacteria on identity badges and lanyards Hospital identity badges: a possible source of healthcare- acquired infection? |
| cord-319208-jrxz59bb | What's hanging around your neck? |
| cord-319208-jrxz59bb | authors: Ting, Chun Yi; Cheng, Daryl R.; Kotsanas, Despina; Kirkwood, Carl D.; Bogdanovic- Sakran, Nada; Stuart, Rhonda L.; Buttery, Jim P. title: Are identity badges and lanyards in pediatrics potentially contaminated with viral pathogens? |
| cord-332088-5c77h0of | : can we confidently link bats with emerging deadly viruses? |
| cord-331673-xv1tcugl | Far from Clinical Use? |
| cord-331673-xv1tcugl | Hypericin- Loaded Graphene Oxide Protects Ducks against a Novel Duck Reovirus Graphene- Based"Hot Plate"for the Capture and Destruction of the Herpes Simplex Virus Type 1 Heparan Sulfate Proteoglycans and Viral Attachment: True Receptors or Adaptation Bias? |
| cord-333262-xvfl7ycj | ( G?) means an optional glycine insertion. |
| cord-329527-0rlotyz3 | Taxonomy of the order Mononegavirales: update 2016 H1N1 encephalitis with malignant edema and review of neurologic complications from influenza Neurological complications of middle east respiratory syndrome coronavirus: a report of two cases and review of the literature Human metapneumovirus persists in BALB/ c mice despite the presence of neutralizing antibodies Taxonomy of the order Mononegavirales: update 2018 Bronchiolitis- associated encephalopathy in critically- ill infants: an underestimated complication? |
| cord-329527-0rlotyz3 | what have we learnt from the ordeal? |
| cord-334082-fyxn0g3v | Expression of animal virus genomes Here a virus, there a virus, everywhere the same virus? |
| cord-334108-4ey725dv | an emerging problem? |
| cord-337673-1nau263l | nature abhors a double- strand Role for a bidentate ribonuclease in the initiation step of RNA interference RNA interference is mediated by 21-and 22-nucleotide RNAs Argonaute2, a link between genetic and biochemical analyses of RNAi Single- stranded antisense siRNAs guide target RNA cleavage in RNAi Transgenes and gene suppression: telling us something new? |
| cord-336929-2rnkotqy | key: cord-336929- 2rnkotqy authors: Vieira, Flávia Sarmento; Corrêa, Gladys; Einicker‐Lamas, Marcelo; Coutinho‐Silva, Robson title: Host‐cell lipid rafts: a safe door for micro‐organisms? |
| cord-325325-xw7627x9 | Ribavirin aerosol treatment of influenza Absence of interferon in lungs from fatal cases of influenza Meta- analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment? |
| cord-325325-xw7627x9 | The run on tamiflu-- should physicians prescribe on demand? |
| cord-325325-xw7627x9 | influenza A viruses in mice Lethal H5N1 influenza viruses escape host anti- viral cytokine responses Induction of proinflammatory cytokines in human macrophages by influenza A( H5N1) viruses: a mechanism for the unusual severity of human disease? |
| cord-334365-idjvbcy4 | What Were We Doing before COVID-19 Changed the World? |
| cord-336447-hpnkou41 | A systematic review of asymptomatic infections with COVID-19 Evaluation of COVID-19 RT- q PCR test in multi- sample pools Preliminary prediction of the basic reproduction number of the Wuhan novel coronavirus 2019-nCoV Diagnosis of the coronavirus disease( COVID-19): rRT- PCR or CT? |
| cord-328252-dk54w8z9 | 3C- Like Protease Regulates Its Interferon Antagonism by Cleaving NEMO Ubiquitin in the activation and attenuation of innate antiviral immunity Deubiquitination, a new function of the severe acute respiratory syndrome coronavirus papain- like protease? |
| cord-328252-dk54w8z9 | Cell Host Microbe Quo vadis? |
| cord-328252-dk54w8z9 | to Usurp Ubiquitin and SUMO Host Pathways Human coronaviruses: what do they cause? |
| cord-294312-ju6vuywm | Are there places in the world where one might travel without worrying about rabies? |
| cord-294312-ju6vuywm | Are there special government laboratories that conduct specialized rabies testing? |
| cord-294312-ju6vuywm | Atypical rabies encephalitis in a six- year old boy: clinical, radiological, and laboratory findings Rabies: still a uniformly fatal disease? |
| cord-294312-ju6vuywm | Can I get rabies if I handle blood, feces, or urine? |
| cord-294312-ju6vuywm | Can international public health teams actually halt and remove a moving viral epizootic outbreak in a geographical area? |
| cord-294312-ju6vuywm | Can scientists actually determine the origin of a rabies virus variant by way of genetic testing and methodologies? |
| cord-294312-ju6vuywm | Do coldblooded animals, insects, or birds have a risk for acquiring this deadly disease? |
| cord-294312-ju6vuywm | Is there a relationship between rabies and zombies? |
| cord-294312-ju6vuywm | Is there a way to vaccinate wildlife using a recombinant vaccine dropped from aircraft? |
| cord-294312-ju6vuywm | The first question that comes to mind is"where did the United Kingdom homeopathic pharmacy obtain rabid dog saliva?" |
| cord-294312-ju6vuywm | Where exactly do most cases of rabies occur in the world? |
| cord-294312-ju6vuywm | Which type of animals are often more"at risk"for contracting rabies virus, otherwise known as highrisk animals? |
| cord-330131-yfhrmbvx | The SARS case study: an alarm clock? |
| cord-330131-yfhrmbvx | Then, what about their degradation and salvage? |
| cord-325750-x7jpsnxg | , Mandrillus leucophaeus Isolation of a cDNA from the virus responsible for enterically transmitted non- A, non- B hepatitis Quantitative monitoring of gene expression patterns with a complementary DNA microarray Viral discovery and sequence recovery using DNA microarrays Identification of a novel Gammaretrovirus in prostate tumors of patients homozygous for R462Q RNASEL variant Prostate cancer: XMRV-contaminant, not cause? |
| cord-325750-x7jpsnxg | For example, how far has this new viral metagenomics discipline evolved in its first decade? |
| cord-325750-x7jpsnxg | The discovery of the poliovirus Smallpox and Its Eradication The Greatest Killer-Smallpox in History Discovery of the first virus, the tobacco mosaic virus: 1892 or 1898? |
| cord-325750-x7jpsnxg | What has been learned so far that can be applied to viral discovery and the forecasting of future viral outbreaks? |
| cord-304876-txaoz7oh | Are there clinically relevant nucleoside analogs that are potent against one or multiple respiratory viruses? |
| cord-304876-txaoz7oh | Are there specific amino acid within the active site of(-)ssRNA virus polymerases responsible for the discrimination of 2 0-C- methyl nucleotides? |
| cord-304876-txaoz7oh | Could the exonuclease/ proofreading activity of CoV polymerases excise chain terminators and resume RNA synthesis? |
| cord-304876-txaoz7oh | How were these molecules first identified, and which ones have been approved for commercial use? |
| cord-304876-txaoz7oh | In this case, could the resistance mutations identified in nsp12 alter the chain termination profile of GS-5734, and make it more susceptible to excision? |
| cord-304876-txaoz7oh | What are the current approaches to develop new nucleoside analogs against respiratory RNA viruses? |
| cord-304876-txaoz7oh | What are the molecular determinants of polymerase selectivity against nucleotide analogs? |
| cord-304876-txaoz7oh | Why are n't molecules like ribavirin and its analogs more widely used to treat respiratory viral infections? |
| cord-335116-c83xyev5 | : is it really necessary? |
| cord-335116-c83xyev5 | Relevance of biofilms in pediatric tonsillar disease Is there any correlation between allergy and adenotonsillar tissue hypertrophy? |
| cord-335647-dhcxj7cj | : an introduction Influenza virus binds its host cell using multiple dynamic interactions A surface plasmon resonance assay for the binding of influenza virus hemagglutinin to its sialic acid receptor Variation and infectivity neutralization in influenza Meta- analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment? |
| cord-336212-ueh4q408 | Is There a Case for Quarantine? |
| cord-336212-ueh4q408 | To Eradicate the Virus or Alleviate Fear? |
| cord-339172-210dwhgj | if RNA synthesis would indeed occur inside closed DMVs or VPs, how then are import and export across the double membrane achieved? |
| cord-339744-xrit0w5i | Avian- to- human transmission of H9N2 subtype influenza a viruses: relationship between H9N2 and H5N1 human isolates Cocirculation of avian H9N2 and contemporary"human"H3N2 influenza a viruses in pigs in southeastern China: potential for genetic reassortment? |
| cord-341050-hnuogpqn | Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides Carbohydrate- binding agents: a potential future cornerstone for the chemotherapy of enveloped viruses? |
| cord-304498-ty41xob0 | Does the ExoN mutator phenotype result in more rapid adaptation or attenuation associated with lethal mutational load and rapid extinction during infection in vivo? |
| cord-304498-ty41xob0 | Does the mutator phenotype increase susceptibility to mutagens for lethal mutagenesis? |
| cord-304498-ty41xob0 | How do CoVs maintain a large and complex genome over time while allowing sufficient mutation rates for adaptation and trans- species movement? |
| cord-304498-ty41xob0 | In this case the central unanswered research question remains: by what mechanism does nsp14 increase fidelity? |
| cord-304498-ty41xob0 | Is the fidelity of wt CoV replication fixed by highly selected interactions between the RdRp, ExoN and possibly other viral and cellular proteins or is it flexible in response to altered environmental conditions as has been shown for bacteria such as E. coli? |
| cord-304498-ty41xob0 | What are the limitations to CoV genome diversity in vitro and in vivo? |
| cord-304498-ty41xob0 | clues that the last universal common ancestor possessed an RNA genome? |
| cord-304498-ty41xob0 | subgenomic mouse hepatitis virus replicative intermediates function in RNA synthesis Nidovirus transcription: how to make sense …? |
| cord-340907-j9i1wlak | The question that we must first address is: what constitutes an under- represented sequence in a coding region? |
| cord-339386-sxyeuiw1 | The adaptation of two human coronavirus strains( OC38 and OC43) to growth in cell monolayers Detection of the new human coronavirus HKU1: a report of 6 cases Culturing the unculturable: human coronavirus HKU1 infects, replicates, and produces progeny virions in human ciliated airway epithelial cell cultures Pleomorphic virus- like particles in human faeces Chronic enterocyte infection with coronavirus: one possible cause of the syndrome of tropical sprue? |
| cord-335774-15fhg8o9 | Vector- Borne Zoonotic Dis Phylogeny and origins of hantaviruses harbored by bats, insectivores, and rodents Short report: Phylogenetically distinct hantaviruses in the masked shrew( Sorex cinereus) and dusky shrew( Sorex monticolus) in the United States Isolation and characterization of a hantavirus from lemmus sibiricus: Evidence for host switch during hantavirus evolution Complete genome sequences of Monongahela hantavirus from Pennsylvania Genetic diversity and distribution of Peromyscus- borne hantaviruses in North America Two cases of hantavirus pulmonary syndrome in Randolph county, West Virginia: A coincidence of time and place? |
| cord-335774-15fhg8o9 | Vector- Borne Zoonotic Dis The velocity of climate change Prairie conservation in North America Perspectives on grassland conservation efforts: Should we rewild to the past or conserve for the future? |
| cord-320713-b37c8aye | How do microRNAs regulate gene expression? |
| cord-320713-b37c8aye | How does influenza virus regulate gene expression at the level of mRNA translation? |
| cord-320713-b37c8aye | What determines whether mammalian ribosomes resume scanning after translation of a short upstream open reading frame? |
| cord-320713-b37c8aye | another mechanism for host protein synthesis shutoff? |
| cord-320713-b37c8aye | is the eIF4E cap- binding factor required for viral mRNA translation? |
| cord-320713-b37c8aye | mRNAs Does phosphorylation of the cap- binding protein eIF4E play a role in translation initiation? |
| cord-337361-salby0fu | How do viruses interact with stress- associated RNA granules? |
| cord-337361-salby0fu | Why do RNA viruses recombine? |
| cord-340610-ex2yjyum | The effect of nasal polyp epithelial cells on eosinophil activation Staphylococcus aureus invades the epithelium in nasal polyposis and induces IL-6 in nasal epithelial cells in vitro Influenza A viruses: new research developments Interactions between respiratory syncytial virus and the host cell: opportunities for antivirus strategies? |
| cord-338331-27ic5zen | CDC protocol of realtime RTPCR for influenza A( H1N1) Guidelines for autopsy investigation of sudden cardiac death Rapid detection of respiratory tract viral infections and coinfections in patients with influenza- like illnesses by use of reverse transcription- PCR DNA microarray systems Pandemic A(H1N1)2009 influenza virus detection by real time RT- PCR: is viral quantification useful? |
| cord-331244-zaguyxm5 | An influenza epicenter? |
| cord-331244-zaguyxm5 | Characterisation of H9 subtype influenza viruses from the ducks of southern china: a candidate for the next influenza pandemic in humans? |
| cord-331244-zaguyxm5 | influenza A viruses Pathogenicity and antigenicity of a new influenza A( H5N1) virus isolated from duck meat Induction of proinflammatory cytokines in human macrophages by influenza A H5N1 viruses: a mechanism for the unusual severity of human disease? |
| cord-340537-pdvpmydk | The pathologist Novel human virus? |
| cord-340042-intxyu46 | Structural basis of receptor recognition by SARS- CoV-2 Vaccination against Toxoplasma gondii: an increasing priority for collaborative research? |
| cord-332361-pdoln3nr | Emerging respiratory agents: new viruses for old diseases? |
| cord-332361-pdoln3nr | Incidence and clinical features of hospitalization because of respiratory syncytial virus lower respiratory illness among children less than two years of age in a rural Asian setting Are meteorological parameters associated with acute respiratory tract infections? |
| cord-332361-pdoln3nr | Presumably this is overall rate and standard deviation? |
| cord-333730-qsx0m68e | An open pilot study On chikungunya acute infection and chloroquine treatment Confronting an influenza pandemic with inexpensive generic agents: can it be done? |
| cord-333730-qsx0m68e | Anti- malaria drug chloroquine is highly effective in treating avian influenza A H5N1 virus infection in an animal model Influenza A/ H1N1 vaccination of patients with SLE: can antimalarial drugs restore diminished response under immunosuppressive therapy? |
| cord-333730-qsx0m68e | inhibition with baricitinib in the treatment of autoinflammatory interferonopathies Baricitinib for COVID-19: a suitable treatment? |
| cord-332181-k90i33gp | ( Miles, Helbig,& Michael, 2011, p.11) Pointedly, a number of other politicians even claimed that calls by scientist and the government for more research on Hendra was further evidence that current policies put the needs of flying foxes above the health and welfare of'real'people:"Why do n't we, as an immediate first response, reduce flying fox numbers?. |
| cord-332181-k90i33gp | Why is the government throwing money at research, which will not protect families now?" |
| cord-332181-k90i33gp | public and private faces of expert opinion during the 2009 swine flu pandemic Public apprehension of emerging infectious diseases: are changes afoot? |
| cord-341303-1iayp8oa | How can a technician gain the confidence necessary to call a specimen positive or negative when tissue culture results either disagree or are unavailable? |
| cord-339973-kj56zi59 | Specifically, we asked, could noninvasive bioaerosol sampling detect respiratory viruses in Singapore's MRT network? |
| cord-340629-1fle5fpz | Novel human astroviruses: Novel human diseases? |
| cord-339885-mpzgrogd | Another question was that did all patients with viral community- acquired pneumonia, especially those without evidence of bacteria infection, need to be treated with antibiotics? |
| cord-339885-mpzgrogd | Hence, one of our puzzled questions remained that among viral pneumonia patients, who needed to be treated with antiviral agents? |
| cord-336948-8yqdhcnz | A central question that requires an answer is then: how many viruses are in these small particles? |
| cord-336948-8yqdhcnz | In other words: given an arbitrary number of contamination or infection scenarios, which is the minimum number of sensors needed to detect them, and where should they be placed? |
| cord-336948-8yqdhcnz | The coronavirus pandemic and aerosols: does COVID-19 transmit via expiratory particles? |
| cord-332632-u2ud0vmq | : what resistance and tolerance can teach us about treating infectious diseases Increased ribonuclease expression reduces inflammation and prolongs survival in TLR7 transgenic mice Immune responses against classical swine fever virus: between ignorance and lunacy, Front Innate immunity: quo vadis? |
| cord-332632-u2ud0vmq | TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus Nucleic acids and endosomal pattern recognition: how to tell friend from foe? |
| cord-332632-u2ud0vmq | What can pestiviral endonucleases teach us about innate immunotolerance? |
| cord-332632-u2ud0vmq | von der Biologie zur Bekämpfung Pestivirus control programs: how far have we come and where are we going? |
| cord-337577-dqikrmk7 | A meta- analysis Hemagglutination inhibition antibody titers as a correlate of protection for inactivated influenza vaccines in children Tetanus toxoid immunization to reduce mortality from neonatal tetanus Antibody responses to envelope glycoproteins in HIV-1 infection Where does HIV hide? |
| cord-337577-dqikrmk7 | What level of hepatitis B antibody is protective? |
| cord-337577-dqikrmk7 | where do we stand? |
| cord-304424-048xo7jn | A novel paramyxovirus? |
| cord-304424-048xo7jn | And what exactly did the host look like then? |
| cord-304424-048xo7jn | Are we missing half of the viruses in the ocean? |
| cord-304424-048xo7jn | At what point in host evolution does an RNA viral pathogen arrive? |
| cord-304424-048xo7jn | CRISPR- Cas9 Species- level deconvolution of metagenome assemblies with Hi- C- based contact probability maps Virus discovery: are we scientists or genome collectors? |
| cord-304424-048xo7jn | Metagenomics for the discovery of novel human viruses Global epidemiology of noninfluenza RNA respiratory viruses: data gaps and a growing need for surveillance Viral metagenomics on animals as a tool for the detection of zoonoses prior to human infection? |
| cord-304424-048xo7jn | Other than sampling more broadly and maintaining the exponential growth in Genbank, what are orthogonal challenges for future RNA virus metagenomic studies? |
| cord-304424-048xo7jn | Tombusviridae and Nodaviridae? |
| cord-304424-048xo7jn | What do you get when you cross a picornavirus and a calicivirus? |
| cord-304424-048xo7jn | Where do we begin with RNA virus metagenomics? |
| cord-304424-048xo7jn | Why has RNA virus metagenomics been so successful? |
| cord-345157-fhmhpobi | Who regulates whom? |
| cord-316951-1swlhdz5 | Does it disseminate to other tissues in the host? |
| cord-316951-1swlhdz5 | How does it enter the cell? |
| cord-316951-1swlhdz5 | How does the infection alter the cell? |
| cord-316951-1swlhdz5 | How does the virus enter the host? |
| cord-316951-1swlhdz5 | How is it shed and transmitted? |
| cord-316951-1swlhdz5 | How is the virus released? |
| cord-316951-1swlhdz5 | Pathogenesis also can be defined at the level of the virus- What is the virus receptor? |
| cord-316951-1swlhdz5 | Where does it replicate? |
| cord-334027-xhfmio7k | Could bats act as reservoir hosts for Rift Valley fever virus? |
| cord-334027-xhfmio7k | Do they circulate in rodents and bats? |
| cord-334027-xhfmio7k | Modelling filovirus maintenance in nature by experimental transmission of Marburg virus between Egyptian rousette bats Vertebrate Reservoirs of Arboviruses: Myth, Synonym of Amplifier, or Reality? |
| cord-334027-xhfmio7k | key: cord-334027-xhfmio7k authors: Fagre, Anna C.; Kading, Rebekah C. title: Can Bats Serve as Reservoirs for Arboviruses? |
| cord-333655-lylt7qld | I inhibitor 1-deoxymannojirimycin potentiates the antiviral activity of carbohydrate- binding agents against wild- type and mutant HIV-1 strains containing glycan deletions in gp120 Carbohydrate- binding agents: a potential future cornerstone for the chemotherapy of enveloped viruses? |
| cord-333655-lylt7qld | Lack of complex N- glycans on HIV-1 envelope glycoproteins preserves protein conformation and entry function Impact of mannose- binding lectin on susceptibility to infectious diseases Lectin- carbohydrate interactions: different folds, common recognition principles Noroviruses everywhere: has something changed? |
| cord-333655-lylt7qld | Mannan- binding lectin deficiency-Good news, bad news, does n't matter? |
| cord-344782-ond1ziu5 | Molecular comparison of isolates of an emerging fish pathogen, Koi herpesvirus, and the effect of water temperature on mortality of experimentally infected Koi Is horizontal transmission of the ostreid herpesvirus OsHV-1 in Crassostrea gigas affected by unselected or selected survival status in adults to juveniles? |
| cord-345020-ai5tib7h | Rhinoviruses delayed the circulation of the pandemic influenza A( H1N1) 2009 virus in France Does viral interference affect spread of influenza? |
| cord-347509-2ysw9a0a | Arterial stiffness is associated with low thigh muscle mass in middle- aged to elderly men Is frailty associated with cardiovascular drug use? |
| cord-336157-aqc9zrrm | Does this mean that if we develop vaccines and antiviral drugs to prevent or treat humans against infection by pathogenic arboviruses we will resolve the challenges associated with emerging arboviruses? |
| cord-336157-aqc9zrrm | Rapid determination of viral RNA sequences in mosquitoes collected in the field Detection and monitoring of mosquito flaviviruses in Spain between Surveillance of mosquito- borne viruses in Alberta using reverse transcription polymerase chain reaction with generic primers Detection of novel insect flavivirus sequences integrated in Aedes albopictus( Diptera: Culicidae) in Northern Italy Surveillance of arboviruses in Spanish wetlands: detection of new flavi- and phleboviruses Arboviral survey of mosquitoes in two northern Italian regions in Insect- specific flaviviruses from Culex mosquitoes in Colorado, with evidence of vertical transmission RNAi targeting of West Nile virus in mosquito midguts promotes virus diversification Chikungunya virus adapts to tiger mosquito via evolutionary convergence: a sign of things to come? |
| cord-336157-aqc9zrrm | Therefore, should we attempt global eradication of arthropods? |
| cord-336157-aqc9zrrm | What are the major objectives that need to be addressed if we are to win the war against these versatile viruses that appear to have an infinitesimal variety Factors, strategies and challenges for arbovirus control G Liang et al 3 of strategies to confuse and disorganize our ability to bring them under control? |
| cord-346673-kyc1wks5 | Do rhinoviruses reduce the probability of viral co- detection during acute respiratory tract infections? |
| cord-331714-2qj2rrgd | A/ Anglia/42/72 from semisynanthropic bird species in Rovno Province, the Ukrainian SSR Human and avian viruses of the Hong Kong series Isolation of an influenza virus from a tree sparrow and the infection rate of the virus in wild birds in the mid- Dnieper Region A new avian influenza virus from feral birds in the USSR: recombination in nature? |
| cord-331714-2qj2rrgd | Could they act as matrix protein surrogates? |
| cord-331714-2qj2rrgd | Pathological studies of chickens experimentally infected with two highly pathogenic avian influenza viruses Comparative pathology of chickens experimentally inoculated with avian influenza viruses of low and high pathogenecity Is virulence of H5N2 influenza viruses in chicken associated with loss of carbohydrate from the hemagglutinin? |
| cord-331714-2qj2rrgd | Serological study of influenza virus antibody in deer Comparison of influenza viruses isolated from man and from whales Characterization of two influenza A viruses from a pilot whale Are seals frequently infected with avian influenza viruses? |
| cord-344889-1y4ieamp | when are bacteria important? |
| cord-348876-v55piprx | Emerg Infect Dis Antigenic and genetic characteristics of H5N1 viruses and candidate vaccine viruses developed for potential use in humanvaccines DNA vaccines: ready for prime time? |
| cord-340194-ibli36rq | Are bats spreading Ebola across sub- Saharan Africa? |
| cord-340194-ibli36rq | Ebola Reston in pigs and humans Emerging disease or diagnosis? |
| cord-348141-eskefcwk | Why do viruses cause cancer? |
| cord-339230-cc7gcy5b | Hypersusceptibility to invasive pneumococcal infection in experimental sickle cell disease involves platelet- activating factor receptor Liveattenuated influenza vaccine, but not pneumococcal conjugate vaccine, protects against increased density and duration of pneumococcal carriage after influenza infection in pneumococcal colonized mice Is the CD200/ CD200 receptor interaction more than just a myeloid cell inhibitory signal? |
| cord-339230-cc7gcy5b | I. Experimental transmission and pathology Influenza virus induces bacterial and nonbacterial otitis media Interactions between Streptococcus pneumoniae and influenza virus: a mutually beneficial relationship? |
| cord-339230-cc7gcy5b | What really happened during the 1918 influenza pandemic? |
| cord-344749-omzhhr0k | The pathogenesis of infection with minute virus of mice depends on expression of the small nonstructural protein NS2 and on the genotype of the allotropic determinants VP1 and VP2 Viruses Immunity to Avian leukosis virus: where are we now and what should we do? |
| cord-335279-cfv18qn0 | A Review of Current Understanding and Vaccine Development Viral Equine Encephalitis, a Growing Threat to the Horse Population in Europe? |
| cord-335279-cfv18qn0 | How, When and Why? |
| cord-335279-cfv18qn0 | The First Detection of Equine Coronavirus in Adult Horses and Foals in Ireland Development and Validation of a S1 Protein- Based ELISA for the Specific Detection of Antibodies against Equine Coronavirus Equine Rhinitis A Virus Infection in Thoroughbred Racehorses- A Putative Role in Poor Performance? |
| cord-335279-cfv18qn0 | key: cord-335279-cfv18qn0 authors: Paillot, Romain title: Special Issue “ Equine Viruses ”: Old “ Friends ” and New Foes? |
| cord-346906-1wmp43ti | What transmission precautions best control influenza spread in a hospital? |
| cord-332992-8rmqg4rf | : what do we know so far? |
| cord-332992-8rmqg4rf | Front Public Health Trained immunity: a tool for reducing susceptibility to and the severity of SARS- CoV-2 infection Complement as a target in COVID-19? |
| cord-332992-8rmqg4rf | Indeed, demographic differences as well as differences in health status, health care, COVID-19 treatment and cause of death assessment( i.e. did a person die with or die from COVID-19?), may explain the differences in reported case- fatality rates between different countries. |
| cord-332992-8rmqg4rf | SARS- CoV-2 Are pangolins the intermediate host of the 2019 novel coronavirus( SARS- CoV-2)? |
| cord-332992-8rmqg4rf | The possible mechanisms of action of 4-aminoquinolines( chloroquine/ hydroxychloroquine) against SARS- CoV-2 infection( COVID-19): a role for iron homeostasis? |
| cord-331289-02411gfv | A review on its molecular characteristics and role in medicine Hepatitis B virus testing by minipool nucleic acid testing: does it improve blood safety? |
| cord-331289-02411gfv | A single mutation in chikungunya virus affects vector specificity and epidemic potential Parvovirus transmission by blood products-a cause for concern? |
| cord-331289-02411gfv | Is the incidence and prevalence of inhibitors greater with recombinant products? |
| cord-331289-02411gfv | Prevalence of nucleic acid sequences specific for human parvoviruses, hepatitis A and hepatitis E viruses in coagulation factor concentrates Evidence for the continued transmission of parvovirus B19 in patients with bleeding disorders treated with plasma- derived factor concentrates Human parvovirus B19 Viral pathogens Hepatitis E screening for blood donations: an urgent need? |
| cord-331289-02411gfv | Use and interpretation The reliability of HBV core antibody in serological screening for hepatitis B virus World Health Organisation( WHO) Laboratory diagnostics for hepatitis C virus infection Hepatitis C virus core antigen testing: role in diagnosis, disease monitoring and treatment Hepatitis C diagnostics: clinical evaluation of the HCVcore antigen determination Transfusion- transmitted hepatitis E: is screening warranted? |
| cord-339423-5qym9dsf | Le comportement alimentaire a- t- il été responsable de l'épidémie de SRAS? |
| cord-339423-5qym9dsf | ces émergences multiples sont elles le fruit du hasard ou s'agit- il plutôt d'un phénomène auquel il va falloir que l'on s'habitue? |
| cord-339423-5qym9dsf | memory and extinction Genetic variability: the key problem in the prevention and therapy of RNA- based virus infections Outbreak of poliomyelitis in Hispaniola associated with circulating type 1 vaccine- derived poliovirus Recombinant vaccine- derived poliovirus in Madagascar Prairie dog: cuddly pet or Trojan horse? |
| cord-344006-0iq9s94n | In patients of COVID-19, what are the symptoms and clinical features of mild and moderate cases? |
| cord-344006-0iq9s94n | what next? |
| cord-341923-jwckbdnb | Developing new antiviral agents for influenza treatment: what does the future hold? |
| cord-341923-jwckbdnb | H1N1 influenza A virusassociated acute lung injury: response to combination oseltamivir and prolonged corticosteroid treatment A rationale for using steroids in the treatment of severe cases of H5N1 avian influenza Delayed antiviral plus immunomodulator treatment still reduces mortality in mice infected by high inoculum of influenza A/ H5N1 virus Confronting an influenza pandemic with inexpensive generic agents: can it be done? |
| cord-341923-jwckbdnb | convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment? |
| cord-341101-5yvjbr5q | A new virus isolated from the human respiratory tract Identification of a new human coronavirus Characterization and complete genome sequence of a novel coronavirus, coronavirus HKU1, from patients with pneumonia Coronavirus as a possible cause of severe acute respiratory syndrome Identification of a novel coronavirus in patients with severe acute respiratory syndrome Koch's postulates fulfilled for SARS virus Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia A Novel Coronavirus from Patients with Pneumonia in China Severe acute respiratory syndrome- related coronavirus: The species and its viruses-a statement of the Coronavirus Study Group Outbreak of pneumonia of unknown etiology in Wuhan, China: The mystery and the miracle Drug treatment options for the 2019-new coronavirus( 2019-nCoV) Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies Chloroquine and hydroxychloroquine as available weapons to fight COVID-19 COVID-19: a recommendation to examine the effect of hydroxychloroquine in preventing infection and progression Comparison of the antiviral activity in vitro of some non- steroidal antiinflammatory drugs Antihistaminics, local anesthetics, and other amines as antiviral agents Effect of chloroquine on the growth of animal viruses Effects of chloroquine on viral infections: an old drug against today's diseases? |
| cord-341101-5yvjbr5q | Focus on recent advancements Pharmacokinetics and cellular uptake of 4-aminoquinoline antimalarials Therapy and pharmacological properties of hydroxychloroquine and chloroquine in treatment of systemic lupus erythematosus, rheumatoid arthritis and related diseases Melanin: blackguard or red herring? |
| cord-323683-9h9mld6x | How does wastewater treatment affect the distribution and fate of viruses and how well do viruses survive after the disposal of untreated effulent? |
| cord-323683-9h9mld6x | How many types of viruses are present in effluent, how numerous are they and what is their pathogenic potential? |
| cord-323683-9h9mld6x | Is disinfection of effluents necessary? |
| cord-323683-9h9mld6x | So how worried need we be about viruses in effluent? |
| cord-323683-9h9mld6x | What methods are available and practicable for the removal of viruses from effluents, how do these work and is there a recommended procedure? |
| cord-336510-qzm9wgde | NF- kappa B induction of major histocompatibility class I and beta 2-microglobulin gene expression in transfected human neuroblastoma cells Complex formation of the interferon( IFN) consensus sequence- binding protein with IRF-1 is essential for murine macrophage IFN- gamma- induced iNOS gene expression Does nitric oxide play a critical role in viral infections? |
| cord-336510-qzm9wgde | NO or no NO? |
| cord-336510-qzm9wgde | The acquisition of herpes simplex virus during pregnancy Neonatal herpes simplex virus infection in relation to asymptomatic maternal infection at the time of labor Herpes simplex virus infections of women and their offspring: implications for a developed society Neonatal herpes simplex virus infections: is there a role for immunoglobulin in disease prevention and therapy? |
| cord-336510-qzm9wgde | interferon- beta mRNA levels in human fibroblasts Is Wiskott- Aldrich syndrome a cell trafficking disorder? |
| cord-333810-57d4oopv | A- t- on un début d'explication du fait que les chauves- souris sont des réservoirs de nombreux virus? |
| cord-333810-57d4oopv | Comment les grands singes peuvent- ils se contaminer? |
| cord-333810-57d4oopv | do nt le réservoir est constitué de rongeurs? |
| cord-333810-57d4oopv | où les singes contraints de modifier leur alimentation consommaient des fruits contaminés par les chauves- souris, est- ce exact? |
| cord-333810-57d4oopv | à celui que vous avez exposé ont- ils été observés? |
| cord-343963-99rd3o79 | Hepatitis C Virus induces the mitochondrial translocation of Parkin and subsequent mitophagy Autophagy and RNA virus interactomes reveal IRGM as a common target MicroRNAs and immunity: novel players in the regulation of normal immune function and inflammation How do microRNAs regulate gene expression? |
| cord-343963-99rd3o79 | NS5A nonstructural protein: a new paradigm for phosphorylation- dependent viral RNA replication? |
| cord-344009-hm36pepp | One of the salient questions regarding the biology of HIV is: how did it emerge as a human virus? |
| cord-344009-hm36pepp | Under these circumstances, how could eradication occur? |
| cord-344009-hm36pepp | Why was 500,000 the limiting population size, at least in the cities included in Bartlett's study? |
| cord-344576-upsc9cf8 | The global spread of Zika virus: is public and media concern justified in regions currently unaffected? |
| cord-344576-upsc9cf8 | WHO Concern over Zika virus grips the world WHO Director- General summarizes the outcome of the Emergency Committee regarding clusters of microcephaly and Guillain- Barré syndrome Zika virus, what CDC is doing? |
| cord-337712-ylqgraos | Can we contain the COVID-19 outbreak with the same measures as for SARS? |
| cord-337712-ylqgraos | The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin- like cleavage site absent in CoV of the same clade A genomic perspective on the origin and emergence of SARS- coV-2 Structure of the SARS- CoV-2 spike receptor- binding domain bound to the ACE2 receptor Structural and functional basis of SARS- coV-2 entry by using human ACE2 SARS- coV-2 ORF3b is a potent interferon antagonist whose activity is increased by a naturally occurring elongation variant A pneumonia outbreak associated with a new coronavirus of probable bat origin Evolutionary origins of the SARS- CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic Arepangolins the intermediate host of the 2019 novel coronavirus( SARS- CoV-2)? |
| cord-337712-ylqgraos | numerous options, no certainty for a versatile virus Antivirals against Coronaviruses: candidate drugs for SARS- coV-2 treatment? |
| cord-329050-vzsy6xw1 | COVID-19 subverted global health? |
| cord-329050-vzsy6xw1 | What can birds tell us about the migration physiology of bats? |
| cord-329050-vzsy6xw1 | Why are birds and bats reservoirs of so many zoonotic viruses Chen et al., 2014; Hayman, 2016; Olival et al., 2017; Miłek and Blicharz- Domańska, 2018; Venkatesh et al., 2018; Wong et al., 2019)? |
| cord-329050-vzsy6xw1 | Why are there so many species in the tropics? |
| cord-329050-vzsy6xw1 | flu from bats or a relic from the past? |
| cord-329050-vzsy6xw1 | with focus on epidemiology and diagnosis in wild birds Reproduction and survival in the city: which fitness components drive urban colonization in a reed- nesting waterbird? |
| cord-349011-kxhpdvri | Where in the Cell Are You? |
| cord-343690-rafvxgx1 | -most important oncogene in cats? |
| cord-343690-rafvxgx1 | Feline husbandry, disease and management in the multiple cat environment Molecular analysis of tumours from feline immunodeficiency virus( fiv)-infected cats: An indirect role for fiv? |
| cord-343690-rafvxgx1 | Neoplasia associated with feline immunodeficiency virus infection in cats of southern california Large granular lymphoma in an fiv- positive and felv- negative cat Lymphosarcoma in experimentally induced feline immunodeficiency virus infection Retrospective study of 60 cases of feline lymphosarcoma Exogenous glucocorticoids alter parameters of early feline immunodeficiency virus infection Molecular and immunophenotypical characterization of a feline immunodeficiency virus( fiv)-associated lymphoma: A direct role for fiv in b- lymphocyte transformation? |
| cord-345689-5ns1onkw | How to manipulate these pathogens that are highly pathogenic, in large quantities? |
| cord-341298-mqpovrms | Molecular evidence of HIV-1 transmission in a criminal case Detecting biothreat agents: The laboratory response network Select agent regulations Aum Shinrikyo: Once and future threat? |
| cord-341298-mqpovrms | The 1990 Florida dental investigation Agroterrorism targeting livestock: A review with a focus on early detection systems Did bioweapons test cause a deadly smallpox outbreak? |
| cord-341298-mqpovrms | The Russian biological weapons program: Vanished or disappeared? |
| cord-350964-0jtfc271 | How Important Are Rats As Vectors of Leptospirosis in the Mekong Delta of Vietnam? |
| cord-348860-zaimorg0 | Kaposi's sarcoma- associated herpesvirus: a new DNA tumor virus A genomic perspective on protein families Microarrays under the microscope Microarray techniques in pathology: tool or toy? |
| cord-348860-zaimorg0 | Many experimental studies have gone into establishing the different cellular pathways modulated by the virus, and whether a common theme exists for all viruses or each virus behaves differently? |
| cord-035015-slgywe0c | :"Mitohormesis"for health and vitality Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging? |
| cord-035015-slgywe0c | A Meta- Analysis Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS- CoV-2 Related Disease( COVID-19) Mitochondria accumulate large amounts of quercetin: prevention of mitochondrial damage and release upon oxidation of the extramitochondrial fraction of the flavonoid Quercetin induces mitochondrial biogenesis through activation of HO-1 in HepG2 cells From sunscreens to medicines: Can a dissipation hypothesis explain the beneficial aspects of many plant compounds? |
| cord-035015-slgywe0c | A Systematic Review and Meta- Analysis Caloric Restriction Reprograms the Single- Cell Transcriptional Landscape of Rattus norvegicus Mitochondria-- a nexus for aging, calorie restriction, and sirtuins? |
| cord-035015-slgywe0c | Can an Old Ally Defeat a New Enemy? |
| cord-035015-slgywe0c | Can we test the hypothesis that mitochondrial health= immune health and enhanced resistance to the virus? |
| cord-035015-slgywe0c | Could damaged mitochondria in the lung and/or heart lead to an exacerbation of symptoms if too much oxygen is given to a patient? |
| cord-035015-slgywe0c | Does SARS- CoV-2 modulate mitochondrial function, either indirectly or directly, and if so, in what cells? |
| cord-035015-slgywe0c | Does mitochondrial function explain why morbidity may be greater among men than women? |
| cord-035015-slgywe0c | For instance, would measured VO 2 max show an inverse relationship with morbidity? |
| cord-035015-slgywe0c | In contrast, would those populations showing the highest fitness levels and functioning be more resistant? |
| cord-035015-slgywe0c | Insights into Oxidative Damage Is exercise protective against influenza- associated mortality? |
| cord-035015-slgywe0c | Interplay between MAPK signaling pathway and mitochondrial dynamics Cyclosporine and COVID-19: Risk or favorable? |
| cord-035015-slgywe0c | Intracellular redox state as target for anti- influenza therapy: are antioxidants always effective? |
| cord-035015-slgywe0c | Is there a link between mitochondrial haplotype and resistance? |
| cord-035015-slgywe0c | Mild depolarization of the inner mitochondrial membrane is a crucial component of an anti- aging program Redox- optimized ROS balance: a unifying hypothesis Redox- optimized ROS balance and the relationship between mitochondrial respiration and ROS Mitochondrial uncoupling and longevity-A role for mitokines? |
| cord-035015-slgywe0c | Neuropilin-1 is a host factor for SARS- CoV-2 infection Immune cell extracellular vesicles and their mitochondrial content decline with ageing T cells with dysfunctional mitochondria induce multimorbidity and premature senescence Antigen- specific adaptive immunity to SARS- CoV-2 in acute COVID-19 and associations with age and disease severity Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19 Mitochondrial Dysfunction and the Aging Immune System immunosenescence and inflammaging: a role for mitokines? |
| cord-035015-slgywe0c | Pandemic Lifestyle- induced metabolic inflexibility and accelerated ageing syndrome: insulin resistance, friend or foe? |
| cord-035015-slgywe0c | So why would SARS- CoV-2 do this? |
| cord-035015-slgywe0c | This therefore raises the question, would enhancing/ supporting mitochondrial health help in this population if they become infected and would understanding the role of mitochondria help in deciding treatment regimens? |
| cord-035015-slgywe0c | Thus, would blood- derived epigenetic markers of metabolic age correlate with disease severity before, during and after infection? |
| cord-035015-slgywe0c | What are the SARS- CoV-2 receptors and where are they found? |
| cord-035015-slgywe0c | Why is Life the way it is? |
| cord-035015-slgywe0c | Would pollution lower resistance to the virus? |
| cord-035015-slgywe0c | a modelling study Inflammation resolution: a dual- pronged approach to averting cytokine storms in COVID-19? |
| cord-350151-s75d1hat | Si riscontrano anche delle infezioni simultanee tra influenza e Legionella pneumophila, mentre una coinfezione da Mycoplasma pneumoniae sembra essere insolita( effetto antagonista tra i due microrganismi?) |
| cord-341138-mxjsp3cm | Firstly, when was the introduction of these viruses into their host populations? |
| cord-341138-mxjsp3cm | Fourthly, why are the gibbons in the SEATO facility infected and not animals in the wild? |
| cord-341138-mxjsp3cm | Secondly, why is WMV more closely related to MbRV than to GaLV, even though WMV is the result of an infection of a woolly monkey with GaLV, whereas MbRV is suggested to be the precursor of the GaLV? |
| cord-341138-mxjsp3cm | Three isolates belonging to a new subgroup from the brains of normal gibbons Is gibbon ape leukaemia virus still a threat? |
| cord-346916-jj4l9ydl | : what have we learned and where are we headed? |
| cord-346916-jj4l9ydl | Toll- like receptor 3 in viral pathogenesis: friend or foe? |
| cord-351197-xv6ymc4l | What is for dinner? |
| cord-331343-qzvwwca9 | 15 Let us go back to the plot: what do we know of the novel arenavirus found by Palacios and colleagues? |
| cord-331343-qzvwwca9 | 3, 22 Therefore, to what extent should we be worried by rodent infections in our transplant patients, and should we be screening donors for these emerging pathogens? |
| cord-331343-qzvwwca9 | Does a betaretrovirus infection trigger primary biliary cirrhosis? |
| cord-331343-qzvwwca9 | However, is it avoidable? |
| cord-331343-qzvwwca9 | Will the brute- force approach of high- throughput sequencing catch on for virus discovery? |
| cord-333463-u7je0d1o | ( via IFN- g secretion) contribute to these phenotypes? |
| cord-333463-u7je0d1o | Dampened responsiveness to type I IFN? |
| cord-333463-u7je0d1o | MHC class I? |
| cord-333463-u7je0d1o | Strain specific? |
| cord-333463-u7je0d1o | Strain specific? |
| cord-333463-u7je0d1o | Yellow Fever Flaviviridae Monkeys( lemurs?) |
| cord-342412-azkamnpa | Diagnostic Medical Parasitology Diagnostic Medical Parasitology Acute otitis media in the era of effective pneumococcal conjugate vaccine: will new pathogens emerge? |
| cord-342412-azkamnpa | Emerg Infect Dis Long- term studies of hantavirus reservoir populations in the southwestern United States: Rationale, potential, and methods West Nile Virus: a growing concern? |
| cord-342412-azkamnpa | First outbreak of vancomycin- resistant enterococci in a tertiary hospital in Turkey Epidemic and nonepidemic multidrug- resistant Enterococcus faecium Evaluation of performance and potential clinical impact of ProSpecT Shiga toxin Escherichia coli microplate assay for detection of Shiga Toxin- producing E. coli in stool samples Invasive serotype a Haemophilus influenzae infections with a virulence genotype resembling Haemophilus influenzae type b: emerging pathogen in the vaccine era? |
| cord-342412-azkamnpa | a 6-year follow- up Emerging rickettsioses of the Thai- Myanmar border Is murine typhus re- emerging in Portugal? |
| cord-340423-f8ab7413 | How does the genome structure and lifestyle of a virus affect its population variation? |
| cord-340423-f8ab7413 | Nonreplicative homologous RNA recombination: promiscuous joining of RNA pieces? |
| cord-340423-f8ab7413 | The question that arises is: How do RNA viruses withstand mutation? |
| cord-340423-f8ab7413 | Why do RNA viruses recombine? |
| cord-339152-wfakzb6w | : where are we? |
| cord-339152-wfakzb6w | COVID-19 Trained innate immunity not always amicable Scores of coronavirus vaccines are in competition-how will scientists choose the best? |
| cord-339152-wfakzb6w | Covid-19: what do we know so far about a vaccine? |
| cord-339152-wfakzb6w | How severe and prevalent are Ebola and Marburg viruses? |
| cord-351571-gwtkrt5u | Do rhinoviruses reduce the probability of viral co- detection during acute respiratory tract infections? |
| cord-344970-ud1lhkyi | Coronavirus replication complex formation utilizes components of cellular autophagy Regulation of cAMP- mediated signal transduction via interaction of caveolins with the catalytic subunit of protein kinase A Membrane rafts in host- pathogen interactions Statins: could an old friend help the fight against COVID-19? |
| cord-344970-ud1lhkyi | The role of lipid metabolism in COVID-19 virus infection and as a drug target Use of statins in patients with chronic Hepatitis C Natural small molecules as inhibitors of coronavirus lipiddependent attachment to host cells: a possible strategy for reducing SARS- COV-2 infectivity? |
| cord-332205-ydijp66b | Can you believe that there is not even a unified database for viruses? |
| cord-332205-ydijp66b | Can you imagine that nearly all existing bioinformatical tools are not specifically designed for the context of viruses? |
| cord-332205-ydijp66b | Did you know that virologists currently only know of about 3,200 viral species but that more than 320,000 mammal- associated viruses[ 4] are thought to await discovery? |
| cord-332205-ydijp66b | Global transport networks and infectious disease spread Natural alternatives to in- feed antibiotics in pig production: can immunomodulators play a role? |
| cord-332205-ydijp66b | Interested? |
| cord-332205-ydijp66b | Perhaps there was no time left to take care of viruses? |
| cord-332205-ydijp66b | Why is this? |
| cord-353290-1wi1dhv6 | Why is CpG suppressed in the genomes of virtually all small eukaryotic viruses but not in those of large eukaryotic viruses? |
| cord-353297-jizitnfl | Did bioweapons test cause a deadly smallpox outbreak? |
| cord-352379-q5inrxcm | On the other hand, feline coronavirus vaccines have been proven to be not only inefficacious; worse yet, the?, have been shown to lead to even more severe viral infections in the vaccinated cats[ 78]. |
| cord-346063-7u1a198p | Do any antiviral agents other than neuraminidase inhibitors have potential in the control( prevention or therapy) of influenza A( H5N1) infections? |
| cord-346063-7u1a198p | In an avian flu pandemic, which drugs could be used to treat or prevent infection with influenza A( H5N1) virus? |
| cord-318495-1w74wf02 | Can DVGs be harnessed for the control of virus pathogenesis and spread? |
| cord-318495-1w74wf02 | Do DVGs exist for a reason? |
| cord-318495-1w74wf02 | Does the higher order structure of the influenza virus ribonucleoprotein guide sequence rearrangements in influenza viral RNA? |
| cord-318495-1w74wf02 | How do alterations in the DVG population impact virus evolution and adaptation to new hosts? |
| cord-318495-1w74wf02 | How do host factors impact DVG accumulation and activity? |
| cord-318495-1w74wf02 | Random products or encoded in the viral genome? |
| cord-318495-1w74wf02 | Recent work has provided new appreciation for DVG diversity and the potentially critical role of DVGs in defining the clinical outcome of infections; however, a number of questions remain unanswered: what are the molecular mechanisms driving the generation of DVGs? |
| cord-318495-1w74wf02 | Virus- associated small satellite RNAs and viroids display similarities in their replication strategies What has been happening with viroids? |
| cord-318495-1w74wf02 | Why keep waste lying around? |
| cord-318495-1w74wf02 | neurochemical abnormalities in the central nervous system Defective interfering particles: effects in modulating virus growth and persistence Persistence of virulent Semliki Forest virus in mouse brain following co- inoculation with defective interfering particles Defective interfering virus particles modulate virulence Continuous influenza virus production in cell culture shows a periodic accumulation of defective interfering particles Multiple- hit inhibition of infection by defective interfering particles Defective interfering particles of human parainfluenza virus type 3 are associated with persistent infection in cell culture Defective interfering influenza virus RNAs: time to reevaluate their clinical potential as broad- spectrum antivirals? |
| cord-353509-yfkiaq80 | Does SARS- CoV-2 has a longer incubation period than SARS and MERS? |
| cord-342936-43u7afl3 | A new C- type lectin similar to the human immunoreceptor DC- SIGN mediates symbiont acquisition by a marine nematode Mannose- binding lectin( MBL) and HIV Mannose- binding lectin: do we need it? |
| cord-342936-43u7afl3 | Plant lectins are potent inhibitors of coronaviruses by interfering with two targets in the viral replication cycle Cyanovirin- N binds to the viral surface glycoprotein, GP1, 2 and inhibits infectivity of Ebola virus Safety concerns for the potential use of cyanovirin as a microbicidal anti- HIV agent in Abstracts of the 14th Conference on Retroviruses and Opportunistic Infections Glycosylation and the immune system Dendritic- cell interactions with HIV: infection and viral dissemination Carbohydrate- binding agents: a potential future cornerstone for the chemotherapy of enveloped viruses? |
| cord-342936-43u7afl3 | The role of DC- SIGN and DC- SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination? |
| cord-342936-43u7afl3 | What are the unique features of the CBA concept that differentiate this therapeutic approach from those that are currently available( BOX 2)? |
| cord-354536-c9v9kbw8 | The Ebola epidemic crystallizes the potential of passive antibody therapy for infectious diseases Selection of Vaccinia Virus- Neutralizing Antibody from a Phage- Display Human- Antibody Library Screening of FDA- approved drugs using a MERS- CoV clinical isolate from South Korea identifies potential therapeutic options for Passive Immunotherapy: Assessment of Convalescent Serum Against Ebola Virus Makona Infection in Nonhuman Primates Enhancement of infectivity of a non- syncytium inducing HIV-1 by sCD4 and by human antibodies that neutralize syncytium inducing HIV-1 Convalescent plasma: new evidence for an old therapeutic tool? |
| cord-339382-ii4xurmr | ( PCV2) vaccination of conventional pigs prevents viremia against PCV2 isolates of different genotypes and geographic origins Serologic response to porcine circovirus type 1( PCV1) in infants vaccinated with the human rotavirus vaccine, Rotarix ™: a retrospective laboratory analysis Chicken infectious anemia virus: an example of the ultimate host- parasite relationship Novel gyroviruses, including chicken anaemia virus, in clinical and chicken samples from South Africa Characterization of a novel gyrovirus in human stool and chicken meat Polyomaviruses and human cancer: molecular mechanisms underlying patterns of tumorigenesis Human exposure to bovine polyomavirus: a zoonosis? |
| cord-339382-ii4xurmr | A metagenomic assessment of viral contamination on fresh parsley plants irrigated with fecally tainted river water Adenovirus and norovirus contaminants in commercially distributed shellfish Les adénovirus non- humains- Un risque zoonotique? |
| cord-339382-ii4xurmr | Can plant virus infect human being? |
| cord-339382-ii4xurmr | teno sus virus species k2b from pigs in the United States and lack of association with post- weaning multisystemic wasting syndrome or mulberry heart disease Torque teno sus virus in pigs: an emerging pathogen? |
| cord-352619-s2x53grh | A review of porcine circovirus 2-associated syndromes and diseases Porcine circovirus diseases Experimental reproduction of severe wasting disease by co- infection of pigs with porcine circovirus and porcine parvovirus Concurrent infections are important for expression of porcine circovirus associated disease Circovirus in domestic and wild carnivores: An important opportunistic agent? |
| cord-354035-i3sl2r0k | Viruses Emerging influenza strains in the last two decades: a threat of a new pandemic? |
| cord-343350-04e6wvov | ( Boone) post- larvae Fenneropenaeus indicus is protected from white spot disease by oral administration of inactivated white spot syndrome virus Doublestranded RNA induces sequence- specific antiviral silencing in addition to nonspecific immunity in a marine shrimp: convergence of RNA interference and innate immunity in the invertebrate antiviral response? |
| cord-343350-04e6wvov | An RNA- directed nuclease mediates post- transcriptional gene silencing in Drosophila cells Argonaute2, a link between genetic and biochemical analyses of RNAi Single- stranded antisense siRNAs guide target RNA cleavage in RNAi RNA silencing: no mercy for viruses? |
| cord-343350-04e6wvov | Is RNA interference involved in intrinsic antiviral immunity in mammals? |
| cord-343350-04e6wvov | Viral subversion of the immune system Regulation of apoptosis by viral gene products Does hyperthermia increase apoptosis in white spot syndrome virus( WSSV)-infected Litopenaeus vannamei? |
| cord-349358-leicos9j | Again, as with other drugs in development against HIV infection, we are confronted with the following major questions: what are the potential side effects from such an approach, and what would be the therapeutic dose window? |
| cord-349358-leicos9j | In other words, what would be the preferred delivery system to use in animals and later on in humans? |
| cord-343347-guciupc8 | Efficacy or effectiveness? |
| cord-343347-guciupc8 | In 2010, Weinberg and Szilagyl eloquently approached the issues of efficacy and effectiveness clarifying the road to correctly answer the relevant but complex question:"How well does the candidate vaccine prevent the disease for which it was developed? |
| cord-343347-guciupc8 | The aging innate immune system Reduction in acute gastroenteritis hospitalizations among us children after introduction of rotavirus vaccine: analysis of hospital discharge data from 18 US states Resolving the pneumococcal vaccine controversy: are there alternatives to randomized clinical trials? |
| cord-353190-7qcoxl81 | Different roles for CD4þ and CD8þ T lymphocytes and macrophage subsets in the control of a generalized virus infection Correlates of protective immunity in poxvirus infection: where does antibody stand? |
| cord-355685-wgad0eoh | Towards prediction paradise? |
| cord-336554-n8n5ii5k | An analysis based on decade- long structural studies of SARS Do viral infections mimic bacterial sepsis? |
| cord-336554-n8n5ii5k | COVID-19 treatment by repurposing drugs until the vaccine is in sight Tissue specific up regulation of ACE2 in rabbit model of atherosclerosis by atorvastatin: role of epigenetic histone modifications ACE 2: more of Ang 1- 7 or less Ang II? |
| cord-336554-n8n5ii5k | COVID-19? |
| cord-336554-n8n5ii5k | Dexamethasone for COVID-19? |
| cord-336554-n8n5ii5k | Ribavirin, remdesivir, sofosbuvir, galidesivir, and tenofovir against SARS- CoV-2 RNA dependent RNA polymerase( RdRp): a molecular docking study Computational target- based drug repurposing of elbasvir, an antiviral drug predicted to bind multiple SARS- CoV-2 proteins COVID-19 and chronological aging: senolytics and other anti- aging drugs for the treatment or prevention of corona virus infection? |
| cord-336554-n8n5ii5k | an open- label, randomised, phase 2 trial Mechanisms of coronavirus cell entry mediated by the viral spike protein SARS- CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? |
| cord-341155-3d64mso0 | Hepatitis C- contamination of toothbrushes: myth or reality? |
| cord-341155-3d64mso0 | The role of household contacts in the transmission of group A streptococci Salivary cytomegalovirus( CMV) shedding, glycoprotein B genotype distribution, and CMV disease in human immunodeficiency virus- seropositive patients Detection of Ebola virus in oral fluid specimens during outbreaks of Ebola virus hemorrhagic fever in the Republic of Congo Ecology of Haemophilus influenzae and Haemophilus parainfluenzae in sputum and saliva and effects of antibiotics on their distribution in patients with lower respiratory tract infections Varicellazoster virus DNA level and facial paralysis in Ramsay Hunt syndrome Quantitation of varicella- zoster virus DNA in patients with Ramsay Hunt syndrome and zoster sine herpete Practice of feeding premasticated food to infants: a potential risk factor for HIV transmission Detection of human Betaherpesvirinae in saliva and urine from immunocompromised and immunocompetent subjects Human herpesvirus 8 primary infection occurs during childhood in Cameroon, Central Africa Saliva as a diagnostic tool for periodontal disease: current state and future directions Global burden and epidemiology of tuberculosis Epstein- Barr virus reactivation and upper- respiratory illness in elite swimmers Oral fluid, a substitute for serum to monitor measles IgG antibody? |
| cord-341155-3d64mso0 | The utility of whole saliva to detect the oral presence of periodontopathic bacteria Do periodontopathogens disappear after full- mouth tooth extraction? |
| cord-341155-3d64mso0 | report of two cases Oral Helicobacter pylori: can we stomach it? |
| cord-354582-fniymnmf | The SARS, MERS and novel coronavirus( COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? |
| cord-355906-yeaw9nr8 | Case series from a tertiary care hospital in Sri Lanka Breast milk as a possible route of vertical transmission of dengue virus? |
| cord-352475-cmmpy5u7 | A new hope for antivirals Anti- Viral Surface Coating to Prevent Spread of Novel Coronavirus( COVID-19) Through Touch Nanoparticles as antiviral agents against adenoviruses Antiviral activity of silver nanoparticle/ chitosan composites against H1N1 influenza A virus Reusable and recyclable graphene masks with outstanding superhydrophobic and photothermal performances Antiviral activity of graphene- silver nanocomposites against non- enveloped and enveloped viruses Cuprous Oxide Particle Dispersion Liquid Antibacterial/ Antiviral Coating Material, and Method for Forming Antibacterial Coating Composition, Resin Composition and Antiviral Product Fluid Compositions that can Form a Coating Having Antiviral Properties Anti- infective properties of the golden spice curcumin Synthesis of chitosan incorporated neem seed extract( Azadirachta indica) for medical textiles Physical distancing, face masks, and eye protection to prevent person- to- person transmission of SARS- CoV-2 and COVID-19: A systematic review and meta- analysis A novel cysteine- linked antibacterial surface coating significantly inhibits bacterial colonization of nasal silicone prongs in a phase one pre- clinical trial Public health- Next flu pandemic: What to do until the vaccine arrives? |
| cord-352475-cmmpy5u7 | Are they"Fenton- like"or not? |
| cord-351365-dc9t3vh3 | Fact or fiction? |
| cord-351365-dc9t3vh3 | What Is a Quasispecies? |
| cord-344093-3bniy5b5 | Viral infection and pulmonary hypertension: is there an association? |
| cord-344093-3bniy5b5 | a mechanism for the unusual severity of human disease? |
| cord-344093-3bniy5b5 | inhibits lung edema clearance during influenza infection Approaching the asymptote? |
| cord-344093-3bniy5b5 | interferon: friend or foe? |
| cord-308066-lrbi5198 | : is there a host restricted circulation of influenza viruses in sympatric ducks and coots? |
| cord-308066-lrbi5198 | Can we continue to prepare and respond to such pathogens by strictly defensive measures aimed at the human H S? |
| cord-308066-lrbi5198 | China culls wild animals to prevent new SARS threat Venezuelan equine encephalitis Characterization of H5N1 influenza viruses that continue to circulate in geese in southeastern China Occurrence of rabies in a wolf population in northeastern Alaska Rabies virus in the decomposed brain of an Ethiopian wolf detected by nested reverse transcription- polymerase chain reaction Factors influencing the incidence and scale of bovine tuberculosis in cattle in southwest England Transmissible spongiform encephalopathies in nondomestic animals: origin, transmission and risk factors Emergence of raccoon rabies in Connecticut, 1991- 1994: spatial and temporal characteristics of animal infection and human contact Experimental rabies infection in wild rodents Disease management strategies for wildlife Naturally acquired simian retrovirus infections in central African hunters Foot- and- mouth disease in the UK: what should we do next time? |
| cord-308066-lrbi5198 | How are we surveilling and preparing for the next pandemic of influenza? |
| cord-308066-lrbi5198 | Koch's postulates fulfilled Are predators good for your health? |
| cord-308066-lrbi5198 | So given the proven record of achievement of a medical or technological approach to defending humans from invasion by infectious organisms, is there much to be gained by examining processes, antecedent to human spillover, for potential vulnerabilities and as intervention targets, as a complement to ongoing efforts to improve human- based disease prevention activities? |
| cord-308066-lrbi5198 | The evolution of H5N1 influenza viruses in ducks in southern China Risk factors for Nipah virus infection among abattoir workers in Singapore Zoonotic viruses of wildlife: hither from yon Passive surveillance as an instrument to identify risk factors for fatal Rocky Mountain spotted fever: is there more to learn? |
| cord-308066-lrbi5198 | The impact of badger removal on the control of tuberculosis in cattle herds in Ireland Molecular characterization of H9N2 influenza viruses: were they the donors of the"internal"genes of H5N1 viruses in Hong Kong? |
| cord-308066-lrbi5198 | What Are the Tools? |
| cord-308066-lrbi5198 | Whose problem is it? |
| cord-308066-lrbi5198 | Would there be a payoff from large investments to improve surveillance and knowledge of known or potential zoonotic pathogens circulating among wildlife H R populations? |
| cord-308066-lrbi5198 | infected non- human primates( NHP) in Africa Preventing the westward spread of rabies Costs and benefits of rabies control in wildlife in France Occurrence of rabies in wolves of Alaska California state mosquito- borne virus surveillance and response plan: a retrospective evaluation using conditional simulations Animal origins of SARS coronavirus: possible links with the international trade in small carnivores Implications of BSE policy for livestock production and veterinary services in the United Kingdom Principles and practice of public health surveillance Molecular strategies for interrupting arthropodborne virus transmission by mosquitoes Mammals, small and large: the ecological implications of size Bovine spongiform encephalopathy( BSE): the end of the beginning or the beginning of the end? |
| cord-308066-lrbi5198 | would such a vaccine immunize sufficient numbers of waterfowl to reduce the susceptible population if widely dispersed among migratory staging areas? |
| cord-354151-psog34u3 | Do rhinoviruses reduce the probability of viral co- detection during acute respiratory tract infections? |
| cord-354151-psog34u3 | Does viral interference affect spread of influenza? |
| cord-351170-belbcrcd | ( QMRA) Performance of Viruses and Bacteriophages for Fecal Source Determination in a Multi- laboratory, Comparative Study Are Microbial Indicators and Pathogens Correlated? |
| cord-351170-belbcrcd | : Can We Kill Them All? |
| cord-351170-belbcrcd | The Perfect Human Pathogens? |
| cord-354068-4qlk6y7h | A hitherto unknown infectious disease contracted from monkeys Filoviridae: A taxonomic home for marburg and ebola viruses? |
| cord-354068-4qlk6y7h | Recombinant human activated protein c for the postexposure treatment of ebola hemorrhagic fever Marburg and ebola hemorrhagic fevers: Does the primary course of infection depend on the accessibility of organ- specific macrophages? |
| cord-329145-424vv8a8 | ( quotation marks dropped:''KE261''? |
| cord-329145-424vv8a8 | Furthermore, as in other nomenclatures described above, it is unclear which vernacular name of a given animal ought to be used( for instance: should''cougar''be used, or should''puma,''''mountain lion''or''mountain cat''be chosen?). |
| cord-329145-424vv8a8 | However, its implementation is complicated by the requirement that virus species names be listed when in practice virus names are( and should be) used instead[ 4, 7, 15,[ 28][ 29][ 30] and the problem that host designation permits the use of non- standardized host names that lack specificity( such as''hot pepper''? |
| cord-329145-424vv8a8 | Instead, the authors provide simple examples for the''species of origin''denominator, such as''mouse''or''bat,''which could be more descriptive( which kind of''mouse''or''bat''?), given that there are over a thousand different animals assigned to a roughly equal number of different mouse and bat species. |
| cord-329145-424vv8a8 | Its disadvantages are that( a) it has become partially redundant because the three''antigenic types''of''influenza virus''have been reclassified as three different viruses belonging to three different species( influenza A/ B/ C virus, species Influenza A/ B/ C virus);( b) host designation permits the use of non- standardized animal names that lack specificity( such as''duck''? |
| cord-329145-424vv8a8 | Should all other biologists follow the lead of virologists and stop italicizing the names of living organisms? |
| cord-329145-424vv8a8 | which kind of duck?); and( c) it does not distinguish between strains and variants. |
| cord-329145-424vv8a8 | which kind of hot pepper?). |
| cord-350925-1h6pbfwp | : It May Be Molecular methods used to estimate thermal inactivation of a prototype human norovirus: More heat resistant than previously believed? |
| cord-350925-1h6pbfwp | Possible role of Dewar photoproducts in solar mutagenesis COVID-19, SARS and MERS: are they closely related? |
| cord-350925-1h6pbfwp | The SARS, MERS and novel coronavirus( COVID-19) epidemics, the newest and biggest global health threats: what lessons have we learned? |
| cord-330852-n7j0c4ne | ( Fig. 6.5D)? |
| cord-330852-n7j0c4ne | ( Patargias et al., 2006): is the p7 bundle just sensitive to protons but does not conduct them? |
| cord-330852-n7j0c4ne | How can a protein be defined as a channel? |
| cord-330852-n7j0c4ne | How does knowledge about the mechanism of function fit into this wish? |
| cord-330852-n7j0c4ne | Or is p7 also a proton conductor similar to M2? |
| cord-330852-n7j0c4ne | Or is the interaction with the host to be seen as a kind of"host based ligand"closing the channel while without the host protein the channel is open; or do other ligands trigger activity? |
| cord-330852-n7j0c4ne | What makes knowledge of the mechanism of function so important? |
| cord-330852-n7j0c4ne | With further analogy to M2, the question arises, can the protein also be built by less than the six units as it is proposed to date? |
| cord-342124-jdv17u86 | Are bats special? |
| cord-342124-jdv17u86 | Are bats"special"as reservoirs for emerging viruses? |
| cord-342124-jdv17u86 | Review of general concepts and use in preventive veterinary medicine Bats and zoonotic viruses: Can we confidently link bats with emerging deadly viruses? |
| cord-342124-jdv17u86 | Why infectious disease research needs community ecology Bats are able to maintain long- term social relationships despite the high fission- fusion dynamics of their groups Drivers of disease emergence and spread: Is wildlife to blame? |
| cord-355181-affuyn8z | : Can an endodontist take the lead in point- of- care COVID-19 testing? |
| cord-355181-affuyn8z | Can Antimicrobial Copper- Based Alloys Help Suppress Infectious Transmission of Viruses Originating from Human Contact with High- Touch Surfaces? |
| cord-355181-affuyn8z | What does viral RNA load really mean? |
| cord-354848-7aakik9a | The rise of Zika infection and microcephaly: what can we learn from a public health emergency? |
| cord-354848-7aakik9a | What changes in current practice are likely to improve outcomes? |
| cord-354848-7aakik9a | What is current practice? |
| cord-355872-z6vsjmxn | : can we ever expect the unexpected? |
| cord-355872-z6vsjmxn | A strategy to estimate unknown viral diversity in mammals Public health threat of new, reemerging, and neglected zoonoses in the industrialized world Viral metagenomics on animals as a tool for the detection of zoonoses prior to human infection? |
| cord-355872-z6vsjmxn | How does one predict when and where a pathogen will jump a species barrier or emerge into a new population that could rapidly spread into new geographic regions? |
| cord-347039-eap592i7 | Are MHC proteins cellular receptors for CMV? |
| cord-347039-eap592i7 | I fold a recognition- associated structure? |
| cord-347039-eap592i7 | Important questions to be answered include:( 1) Do other activating NK- cell receptors have specialized functions in virus recognition? |
| cord-347039-eap592i7 | What is the extent of the repertoire of target molecules for NK- cell- activating receptors? |
| cord-356188-rwf78stz | : what decides the outcome? |
| cord-356188-rwf78stz | The effect of influenza on hospitalizations, outpatient visits, and courses of antibiotics in children Children hospitalized with 2009 novel influenza A(H1N1) in California Age- specific differences in influenza A epidemic curves: do children drive the spread of influenza epidemics? |
| cord-356188-rwf78stz | The role of the antibody response in influenza virus infection Antigenic fingerprinting of H5N1 avian influenza using convalescent sera and monoclonal antibodies reveals potential vaccine and diagnostic targets Pre- existing immunity against swine- origin H1N1 influenza viruses in the general human population Human dendritic cell deficiency: the missing ID? |
| cord-355771-pxkkd3s1 | Could the current heightened public awareness of viruses and their devastating physiological power result in heightened excitement for virus- based cancer therapies? |
| cord-355771-pxkkd3s1 | Development of viral vaccine platforms has already seen a surge of interest, but what about viral immunotherapies for the treatment of cancer? |
| cord-355771-pxkkd3s1 | Will our new 2020'virological'reality produce a wave of support for the development of oncolytic viruses( OV) as a means to'flatten the curve'of one of the leading causes of death worldwide? |
| cord-350948-oog6m4h3 | : cord-350948-oog6m4h3 authors: Leclercq, Loïc; Nardello- Rataj, Véronique title: How to improve the chemical disinfection of contaminated surfaces by viruses, bacteria and fungus? |
| cord-350948-oog6m4h3 | : update on replication and pathogenesis Action of disinfectants on canine coronavirus replication in vitro Role of the lipid rafts in the life cycle of canine coronavirus Principles of viral control and transmission Disinfection, Sterilization, and Preservation Epstein- Barr virus- induced membrane antigens: immunochemical characterization of Triton X-100 solubilized viral membrane antigens from EBV- superinfected Raji cells Aqueous mixtures of di- n- decyldimethylammonium chloride/ polyoxyethylene alkyl ether: dramatic influence of tail/ tail and head/ head interactions on co- micellization and biocidal activity The herpes packaging of viral DNA Chemical disinfeciton of nonporous inanimate surface experimentally contaminated with four human pathogenic viruses Are Quaternary Ammonium Compounds, the Workhorse Disinfectants, Effective against Severe Acute Respiratory Syndrome- Coronavirus-2? |
| cord-350948-oog6m4h3 | Supramolecular assistance between cyclodextrins and didecyldimethylammonium chloride against enveloped viruses: Toward eco- biocidal formulations Modeling of multiple equilibria in the self- aggregation of di- n- decyldimethylammonium chloride/ octaethylene glycol monododecyl ether/ cyclodextrin ternary systems Structure- activity relationship of cyclodextrin/ biocidal double- tailed ammonium surfactant host- guest complexes: towards a delivery molecular mechanism? |
| cord-350948-oog6m4h3 | Towards greener medical applications? |
| cord-337659-x4oywbrj | But, just how much of an improvement would that be? |
| cord-337659-x4oywbrj | In considering the gaps in the U.S. agriculture and food defense capabilities, the main question that must be addressed is: Exactly what level of security do the people of the USA want the agricultural industry to achieve, and our government to enforce, in terms of food safety and biosecurity? |
| cord-337659-x4oywbrj | Molecular evolution and the feasibility of an avian influenza virus becoming a pandemic strain-A conceptual shift Pandemic influenza: are we ready? |
| cord-337659-x4oywbrj | Or, will this threat diminish before it evolves into a more human- specific virus? |
| cord-337659-x4oywbrj | So, how can this be achieved? |
| cord-337659-x4oywbrj | So, how could this be improved? |
| cord-337659-x4oywbrj | This was considered an accidental outbreak, but what if it had been a deliberate attack? |
| cord-337659-x4oywbrj | Will this fine dividing line be crossed soon? |
| cord-347710-ff64y6ef | : where do we stand? |
| cord-347710-ff64y6ef | Hsp90 inhibitors: a potential treatment for latent EBV infection? |
| cord-347710-ff64y6ef | The hepatitis E virus open reading frame 3 product interacts with microtubules and interferes with their dynamics The ins and outs of tubulin acetylation: more than just a post- translational modification? |
| cord-347710-ff64y6ef | diagnostic, prognostic, predictive, and treatment implications Altered states: selectively drugging the Hsp90 cancer chaperone Heat shock proteins promote cancer: it's a protection racket Heat shock proteins and cancer: intracellular chaperones or extracellular signalling ligands? |
| cord-339062-tq0f6d01 | 2) apparently generated all epizootic IAB and IC strains responsible for major outbreaks? |
| cord-339062-tq0f6d01 | As equine populations decline in Latin America, and human and domestic animal populations increase, will the scale and frequency of VEE epizootics decrease? |
| cord-339062-tq0f6d01 | Can epizootic VEEV strains persist in nature in the absence of efficient equine amplification and transmission? |
| cord-339062-tq0f6d01 | Can humans or domestic animals such as cattle replace equines as amplification hosts? |
| cord-339062-tq0f6d01 | Do slight differences in the gene and protein profiles of other enzootic VEEV lineages prevent adaptation to equine hosts and/or epizootic vectors by altering the effect of minor genetic mutations? |
| cord-339062-tq0f6d01 | Is epizootic adaptation to equine and mosquito hosts species- specific, resulting in a loss of fitness for the sylvatic hosts that are required for permanent viral circulation? |
| cord-339062-tq0f6d01 | Why do female Aedes aegypti( Diptera: Culicidae) feed preferentially and frequently on human blood? |
| cord-339062-tq0f6d01 | Why is genotype IV restricted to the Indonesian/ Malaysian region, whereas recent genotypes are geographically more widespread? |
| cord-350747-5t5xthk6 | First, why is elongation on the first template interrupted? |
| cord-350747-5t5xthk6 | Poliovirus neurovirulence depends on the presence of a cryptic AUG upstream of the initiator codon Nonreplicative homologous RNA recombination: promiscuous joining of RNA pieces? |
| cord-350747-5t5xthk6 | Second, does the incomplete nascent strand dissociate alone or together with RdRP? |
| cord-350747-5t5xthk6 | Third, how is the site of the acceptor template chosen to resume synthesis? |
| cord-303265-v6ci69n0 | An optimal degree of physical and chemical heterogeneity for the origin of life? |
| cord-303265-v6ci69n0 | Did they originate before or after a cellular world was in place? |
| cord-303265-v6ci69n0 | Do viruses exist essentially as selfish parasites, or have they played constructive roles in the biosphere? |
| cord-303265-v6ci69n0 | Does virus variation play a role in the unfolding of viral disease processes? |
| cord-303265-v6ci69n0 | Have viruses been maintained as modulators of the population numbers of their host species? |
| cord-303265-v6ci69n0 | How did replicating and coding RNAs first get together? |
| cord-303265-v6ci69n0 | Is cyanoacetylene prebiotic? |
| cord-303265-v6ci69n0 | Is it quasispecies dynamics that characterize RNA and many DNA viruses, a remnant of an adaptive strategy that presided all life forms in the remote past? |
| cord-303265-v6ci69n0 | Is the behavior of present- day viruses at the population level only an inheritance of their origins or a present- day necessity? |
| cord-303265-v6ci69n0 | Or have they? |
| cord-303265-v6ci69n0 | Origin of hepatitis delta virus Bacteriophages and pathogenicity: more than just providing a toxin? |
| cord-303265-v6ci69n0 | What is the origin of viruses? |
| cord-303265-v6ci69n0 | What selective forces have maintained multiple viruses as parasites of unicellular and multicellular organisms? |
| cord-303265-v6ci69n0 | What selective forces might have led to the integration of these features? |
| cord-303265-v6ci69n0 | Why have a few viral forms not outcompeted most other forms? |
| cord-303265-v6ci69n0 | Why should we feel disappointed by our inability to even foresee the possible answers to these luring questions? |
| cord-001521-l36f1gp7 | ( H1N1) 2009 viruses Pandemic A(H1N1)2009 influenza virus detection by real- time RT- PCR: is viral quantification useful? |
| cord-001521-l36f1gp7 | ( iv) What are the epidemiologic and logistical factors that determine the demand- supply balance of passive immunotherapy? |
| cord-001521-l36f1gp7 | 4?? |
| cord-001521-l36f1gp7 | 4?? |
| cord-001521-l36f1gp7 | 4??? |
| cord-001521-l36f1gp7 | 4??? |
| cord-001521-l36f1gp7 | 4??? |
| cord-001521-l36f1gp7 | ? |
| cord-001521-l36f1gp7 | A quantitative risk assessment of exposure to adventitious agents in a cell culture- derived subunit influenza vaccine John's Hopkins Bloomberg School of Public Health Design of an automated laboratory for high- throughput influenza surveillance Human influenza surveillance: the demand to expand Influenza: an emerging disease Avian- to- human transmission of the PB1 gene of influenza A viruses in the 1957 and 1968 pandemics Proinflammatory cytokine responses induced by influenza A( H5N1) viruses in primary human alveolar and bronchial epithelial cells Induction of proinflammatory cytokines in human macrophages by influenza A( H5N1) viruses: a mechanism for the unusual severity of human disease? |
| cord-001521-l36f1gp7 | Consequently, the more important question is''why did children live?'' |
| cord-001521-l36f1gp7 | Ever since, influenza virologists have sought to answer the question''why did young adults die?''by defining the molecular characteristics of the 1918 virus that were responsible for its virulence. |
| cord-001521-l36f1gp7 | H3N2 influenza A viruses in pigs in southeastern China: potential for genetic reassortment? |
| cord-001521-l36f1gp7 | H3N2 influenza A viruses in pigs in southeastern China: potential for genetic reassortment? |
| cord-001521-l36f1gp7 | H5N1 virus Evidence of a cross- protective immune response to influenza A in the cotton rat model Heterosubtypic immunity to influenza A virus: where do we stand? |
| cord-001521-l36f1gp7 | H9N2 influenza A viruses from poultry in Asia have human virus- like receptor specificity Characterization of H9 subtype influenza viruses from the ducks of southern China: a candidate for the next influenza pandemic in humans? |
| cord-001521-l36f1gp7 | H9N2 influenza A viruses from quail in southern China Characterization of the pathogenicity of members of the newly established H9N2 influenza virus lineages in Asia Sequence analysis of the hemagglutinin gene of H9N2 Korean avian influenza viruses and assessment of the pathogenic potential of isolate MS96 Molecular characterization of H9N2 influenza viruses: were they the donors of the''internal''genes of H5N1 viruses in Hong Kong? |
| cord-001521-l36f1gp7 | How does CS-8958 move from the cell membrane to ER ⁄ Golgi? |
| cord-001521-l36f1gp7 | How many severe cases can be offered passive immunotherapy? |
| cord-001521-l36f1gp7 | In the Control of Epidemic and Pandemic Influenza 12- 13 Characterization of an influenza A H5N2 reassortant as a candidate for live- attenuated and inactivated vaccines against highly pathogenic H5N1 viruses with pandemic potential Are there alternative avian influenza viruses for generation of stable attenuated avian- human influenza A reassortant viruses? |
| cord-001521-l36f1gp7 | In vitro and in vivo assay systems for study of influenza virus inhibitors New low- viscosity overlay medium for viral plaque assays Antibacterial and antifungal activities of Cistus incanus and C. monspeliensis leaf extracts Flavan-3-ols and proanthocyanidins from Cistus incanus Inhibition of the infectivity of influenza virus by tea polyphenols Attenuation of inducible respiratory immune responses by oseltamivir treatment in mice infected with influenza A virus Anti- inflammatory activity of macrolides: a new therapeutic potential? |
| cord-001521-l36f1gp7 | Is laninamivir indeed trapped inside ER ⁄ Golgi, and does it make a complex with NA in mice? |
| cord-001521-l36f1gp7 | New technologies for meeting the global demand for pandemic vaccines Confronting the next influenza pandemic with inexpensive generic agents: can it be done? |
| cord-001521-l36f1gp7 | Novel type II transmembrane serine proteases, MSPL and TMPRSS13, proteolytically activate membrane fusion activity of hemagglutinin of highly pathogenic avian influenza viruses and induce their multicycle replication Is virulence of H5N2 influenza viruses in chickens associated with loss of carbohydrate from the hemagglutinin? |
| cord-001521-l36f1gp7 | Pandemic Influenza Preparedness and Response Prophylaxis or treatment? |
| cord-001521-l36f1gp7 | Qué podemos decir ahora? |
| cord-001521-l36f1gp7 | RT- PCR technique for profiling human cytokines, based on external RNA standards, readily automatable for clinical use Role of hypercytokinemia in NF- kap- paB p50 deficient mice after H5N1 influenza A virus infection Developing new antiviral agents for influenza treatment: what does the future hold? |
| cord-001521-l36f1gp7 | The average daily passenger number is 2489 based on the 2009 Annual Statistical Report on Tourism, Tourism Bureau, Taiwan( http://admin.taiwan.net.tw/english/statistics/year.asp? relno=61). |
| cord-001521-l36f1gp7 | The protein- protein interaction map of Helicobacter pylori Development of a real- time RT- PCR for the detection of Swine- lineage Influenza A( H1N1) virus infections Long- term storage and recovery of buccal cell DNA from treated cards Pandemic A(H1N1)2009 influenza virus detection by real time RT- PCR: is viral quantification useful? |
| cord-001521-l36f1gp7 | The role of influenza virus gene constellation and viral morphology on cytokine induction, pathogenesis, and viral virulence Induction of proinflammatory cytokines in human macrophages by influenza A( H5N1) viruses: a mechanism for the unusual severity of human disease? |
| cord-001521-l36f1gp7 | These observations raise the following question: could the host response be modified so patients with severe seasonal and pandemic influenza might have a better chance of surviving? |
| cord-001521-l36f1gp7 | WHO manual on animal influenza diagnosis and surveillance Antigenic characterization of influenza B virus with a new microneutralisation assay: comparison to haemagglutination and sequence analysis Seroprotection rate, meanfold increase, seroconversion rate: which parameter adequately expresses seroresponse to influenza vaccination? |
| cord-001521-l36f1gp7 | Was bacterial pneumonia the predominant cause of death in the 1918- 1919 influenza pandemic? |
| cord-001521-l36f1gp7 | What are the ratelimiting factors in the supply of passive immunotherapy? |
| cord-001521-l36f1gp7 | What is the optimal therapy for patients with H5N1 influenza Meta- analysis: convalescent blood products for Spanish influenza pneumonia: a future H5N1 treatment? |
| cord-001521-l36f1gp7 | What percentage of convalescent individuals( donor percentage) is needed in order for the program to significantly reduce pandemic mortality? |
| cord-001521-l36f1gp7 | World Health Organization WHO outbreak communications guidelines, Geneva: World Health Organization Characterization of H9 subtype influenza viruses from the ducks of southern China: a candidate for the next influenza pandemic in humans? |
| cord-001521-l36f1gp7 | a mechanism for the unusual severity of human disease? |
| cord-001521-l36f1gp7 | did the 2009'swine- origin'influenza A virus( H1N1) emerge? |
| cord-001521-l36f1gp7 | human to pig transmission in Norway? |
| cord-001521-l36f1gp7 | viruses due to substitution of aspartic acid 151 in the catalytic site-role in virus attachment? |
| cord-349225-504kr50e | : what's the end game? |
| cord-349225-504kr50e | Are the functions of an individual viral gene modulated by its genetic context, and is there any evidence for cooperativity? |
| cord-349225-504kr50e | Is complexity and redundancy a viral strategy that enables viruses to infect individuals resistant to some functions? |
| cord-349225-504kr50e | Is there a hierarchy in terms of general importance or do some functions operate only in certain tissues? |
| cord-349225-504kr50e | Many questions therefore remain unanswered, including which genes are needed during primary infection to'conquer the territory'; which genes are required to support active replication; and which genes are required to ensure transmission to a new host in the face of a vigorous host immune response? |
| cord-349225-504kr50e | Moreover, why is there such complexity and functional redundancy? |
| cord-345654-vyz6f3he | Can we rule out that a dedicated research effort with sufficient funds and expertise could produce a highly virulent and transmissible synthetic virus? |
| cord-345654-vyz6f3he | Culicoides and the emergence of bluetongue virus in northern Europe Incriminating bluetongue virus vectors with climate envelope models Why did bluetongue spread the way it did? |
| cord-345654-vyz6f3he | The evolution of host specialization: are trade- offs overrated? |
| cord-345654-vyz6f3he | The experimental evolution of specialists, generalists, and the maintenance of diversity Arbovirus evolution in vivo is constrained by host alternation Trade- offs in host range evolution of plant viruses Emerging viruses: why they are not jacks of all trades? |
| cord-345654-vyz6f3he | Why do RNA viruses recombine? |
| cord-345654-vyz6f3he | Why do bacteria engage in homologous recombination? |
| cord-344408-4ko557n1 | A comparison of bats and rodents as reservoirs of zoonotic viruses: are bats special? |
| cord-344408-4ko557n1 | Froglog Amphibian Conservation Summit Emerging infectious diseases and amphibian population declines Climate and amphibian declines Climate change and amphibian declines: is there a link? |
| cord-344408-4ko557n1 | Is it, then, the responsibility of farmers and vets to ensure that people do not become infected, or of public health practitioners or the general public through improved kitchen hygiene and behaviours? |
| cord-344408-4ko557n1 | The origins of plagues: old and new Risk factors for human disease emergence Population biology of multihost pathogens Population biology of emerging and re- emerging pathogens Host range and emerging and reemerging pathogens Global trends in emerging infectious diseases Middle East Respiratory Syndrome coronavirus in bats, Saudi Arabia Bats: important reservoir hosts of emerging viruses What links bats to emerging infectious diseases? |
| cord-344408-4ko557n1 | What would these global strategies entail? |
| cord-344408-4ko557n1 | an assessment Dynamics and genetics of a disease- driven species decline to near extinction: lessons for conservation Bat white- nose syndrome: an emerging fungal pathogen? |
| cord-344408-4ko557n1 | cord-344408- 4ko557n1 authors: Cunningham, Andrew A.; Daszak, Peter; Wood, James L. N. title: One Health, emerging infectious diseases and wildlife: two decades of progress? |
| cord-350235-yoy3hj3j | W hat is COVID-19? |
| cord-350235-yoy3hj3j | What are the causes, parameters, and effects of this disease? |
| cord-350235-yoy3hj3j | What are the causes, parameters, and effects of this disease? |
| cord-350235-yoy3hj3j | What are the shortand long- term prospects? |
| cord-350235-yoy3hj3j | What are the short‐ and long‐term prospects? |
| cord-350235-yoy3hj3j | What is COVID‐19? |
| cord-355259-779czzzx | ( 2) Can viral neuraminidase use mucin sialic acids as substrates and catalyze the cleavage of them away? |
| cord-355259-779czzzx | ( 3) Is this cleavage sufficient to liberate the virions and allow them to penetrate through the mucus layer? |
| cord-355259-779czzzx | In the present study, we aimed to address the following questions:( 1) Is the virus entrapped or able to penetrate through the native respiratory mucus? |
| cord-355259-779czzzx | Predicting'airborne'influenza viruses:( trans-) mission impossible? |
| cord-355259-779czzzx | Since the majority of viral particles were incapable of penetrating through the mucus layer, why do influenza viruses invade the respiratory tract of the animals after all[ 1, 3, 45]? |
| cord-252769-fe50u028 | , de que fizemos eco, é possível retirar consequências para o quotidiano na procura da prevenção da asma e da atopia? |
| cord-252769-fe50u028 | An association between genes and the environment Gene environment interaction in allergic disease: more questions, more answers? |
| cord-252769-fe50u028 | And the high risk of asthma in children who attend nursery schools, with the greatest amount of infections in the lower respiratory tract 69? |
| cord-252769-fe50u028 | And what about bacterial infections? |
| cord-252769-fe50u028 | Como sair desta encruzilhada? |
| cord-252769-fe50u028 | Endotoxin-stimulated innate immunity: a contributing factor for asthma Does environmental endotoxin exposure prevents asthma? |
| cord-252769-fe50u028 | Frequency of infections in the first years of life and risk of asthma, atopy and airway hyperresponsiveness among schoolage children Is the prevalence of wheeze in children altered by neonatal BCG vaccination? |
| cord-252769-fe50u028 | How would the parallel increase in auto- immune inflammatory diseases, Th 1, expression and asthma and allergy 71 or the fact that autoimmune diseases are higher in asthmatics 64 be explained on that basis? |
| cord-252769-fe50u028 | If we were, how would one explain the rise in the asthma rate seen in the poorer USA neighbourhoods 67? |
| cord-252769-fe50u028 | In 2003, Holtzman 75 unveiled a theory that could be true in some cases: the asthmatic risco de asma em crianças que frequentam infantários, com maior número de infecções do tracto respiratório inferior 69? |
| cord-252769-fe50u028 | In the midst of so much confusion, is it possible to reach any conclusions on asthma and allergy prevention which are applicable to the here and now? |
| cord-252769-fe50u028 | Is virus on its own the culprit or is it the last straw to break the back of a particularly fragile situation, possibly genetically caused? |
| cord-252769-fe50u028 | Mas, claro, isto não significa apoiar certos fundamentalismos already carried out into endotoxins, provide future guidance? |
| cord-252769-fe50u028 | Nesta lógica, como se explica o aumento de prevalência da asma nos bairros pobres dos Estados Unidos 67? |
| cord-252769-fe50u028 | Not all farming environments protect against the development of asthma and wheeze in children Hygiene hypothesis and endotoxin: what is the evidence? |
| cord-252769-fe50u028 | On roots of childhood asthma: the role of respiratory infections Probiotic for the prevention of treatment or allergic diseases Hay fever, hygiene and household size Primary and secondary prevention of allergic asthma Role of microbial burden in aetiology of allergy and asthma Hygiene hypothesis: fact or fiction? |
| cord-252769-fe50u028 | Or how in Africa and Latin America, in areas rife with bilharzia, which promotes Th 2 secretion and IgE synthesis, is the prevalence of that parasite in an inverse correlation with asthma and allergy 68? |
| cord-252769-fe50u028 | Or is it a mere marker? |
| cord-252769-fe50u028 | Ou será um mero marcador? |
| cord-252769-fe50u028 | Será que os estudos genéticos, como os feitos para as endotoxinas, nos poderão orientar futuramente? |
| cord-252769-fe50u028 | Será que temos de mudar os nossos padrões de vida? |
| cord-252769-fe50u028 | The increased prevalence of allergy and the hygiene hypothesis: missing immune deviation, reduced immune suppression, or both? |
| cord-252769-fe50u028 | The many faces of the hygiene hypothesis Asthmatic bronchial epithelial cells have a deficient innate response to infection with rhinovirus Respiratory viral infections and asthma pathogenesis: a critical role for dendritic cells? |
| cord-252769-fe50u028 | Unraveling the complexities Early-- life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma A reformulation of the hygiene hypothesis: maternal infeccious diseases confer protection against asthma in the infant? |
| cord-252769-fe50u028 | What is the path out of this crossroads? |
| cord-252769-fe50u028 | Will we have to change the way we lead our lives? |
| cord-252769-fe50u028 | a gota que faz extravasar a água numa situação de particular fragilidade, eventualmente com causa genética? |
| cord-252769-fe50u028 | cells in the big picture of immunology A reformulation of the hygiene hypothesis: maternal infectious diseases confer protection against asthma in the infant? |
| cord-252769-fe50u028 | facto de as doen ças autoimunes terem elevada prevalência nos asmáticos 64? |
| cord-252769-fe50u028 | the virus, the disease and the immune response Is asthma an infectious disease? |
| cord-346853-0c1qdjb5 | Although the focus on changing human ecology and phylogenetic history was an important and necessary first step, and it will often be impossible to disentangle ecology and genetics when explaining the emergence of a specific pathogen, it is also essential to ask what evolutionary processes are responsible for the appearance and spread of pathogens? |
| cord-346853-0c1qdjb5 | Are certain types of virus more likely to emerge than others? |
| cord-346853-0c1qdjb5 | Are viruses from phylogenetically related host species more likely to undergo cross- species transmission than those viruses from distantly related host species? |
| cord-346853-0c1qdjb5 | Does viral emergence require adaptation to the new host species? |
| cord-346853-0c1qdjb5 | Is recombination a prerequisite for viral emergence? |
| cord-346853-0c1qdjb5 | Perhaps the central question in this respect is whether, following cross- species transmission, emergent viruses must adapt to replicate in their new species, or whether the process of emergence is essentially blind to natural selection? |
| cord-346853-0c1qdjb5 | Specifically, are those viruses from our closest relatives, the simian primates, more able to infect us than those from other mammalian orders? |
| cord-346853-0c1qdjb5 | The key question, therefore, is whether these mutations appear de novo in humans, in the short transmission networks of people who initially suffer avian influenza, or whether they preexist in the avian population, and if the appropriate strain is transmitted, then will emergence follow? |
| cord-346853-0c1qdjb5 | Why might this be so? |
| cord-318853-mxyxwkhx | 5 5'UTR geq/ ml at 16 weeks be visible immunologically, but envelope proteins derived from EeRNA sequences corresponding to~10 6- 7 5'UTR geq/ ml at 4- 6 weeks remain unseen? |
| cord-318853-mxyxwkhx | Analysis of cloned DNA gives cleaner data than PCR sequencing but if 100 clones( and multiple HCV quasispecies clones are highly unlikely to be identical) provides definitive sequence, would we process the 101 st to reveal different and, potentially, critical sequence variations? |
| cord-318853-mxyxwkhx | And if we did, how would we recognise its importance? |
| cord-318853-mxyxwkhx | As clear evidence exists for viral disruption of leptin function[ 106] and virus- associated weight gain in humans[ 107] and monkeys[ 108], is it possible the global epidemics of type II diabetes mellitus, insulin resistance, hyperlipidaemia and obesity now prevalent[ 109][ 110][ 111][ 112][ 113][ 114][ 115][ 116], are just that; epidemics fundamentally caused by viruses that co- opt insulin or leptin or other associated receptors for cell access and generate protein quasispecies that disrupt receptor function? |
| cord-318853-mxyxwkhx | But does this certitude reflect reality, at least for viral RNA quasispecies? |
| cord-318853-mxyxwkhx | But why should specific EeRNA sequence frequencies-in other words, HCV RNA pol fidelity-increase after week 8, facilitating adaptive immune responses? |
| cord-318853-mxyxwkhx | Could it also be that ethnically based epidemics of obesity, diabetes mellitus, hypertension and reno- vascular disease( the'metabolic syndrome'), as seen in PIMA Indians, Nauruans and Australian Aborigines[ 115] have developed not primarily because of exposure to"Western"foods and lifestyles-that, after all, are all- pervasive without necessarily having so dramatic an effect on other groups-but because of chronic or recurrent exposure to viruses, or genotypes of viruses to which their particular repertoire of receptor polymorphisms confer no protection? |
| cord-318853-mxyxwkhx | Finally, if immune mechanisms are unable to clear RNA viruses like HCV and do not cause the reduced viral replication seen during acute infection, are they any more likely to be effective against other RNA viruses? |
| cord-318853-mxyxwkhx | I receptor signaling system in JC virus T antigen- induced primitive neuroectodermal tumors-medulloblastomas Hepatitis C virus down- regulates insulin receptor substrates 1 and 2 through up- regulation of suppressor of cytokine signaling 3 Vaccinia virus and the EGF receptor: a portal for infectivity? |
| cord-318853-mxyxwkhx | Is important sequence likely to be present at frequencies of http://www.virologyj.com/content/2/1/70< 1%? |
| cord-318853-mxyxwkhx | Is it possible foetal tolerance is mediated by regulating the fidelity of foetal DNA dependent RNA transcriptases to ensure any cell- surface antigens are expressed heterogeneously and at levels below the threshold of maternal immune responsiveness? |
| cord-318853-mxyxwkhx | Is it possible that self- limiting infections like influenza and SARS also autoregulate their replication, and, like HCV or HBV, become partially dormant, yet remain transcriptionally active, in the face of an active and powerful immune response? |
| cord-318853-mxyxwkhx | The expected consequences disruption of receptor function by variant viral proteins might explain many common biochemical pathologies; For example, what effect would chronic blockade of parathyroid( PTH) receptors by viral proteins have on PTH levels, the parathyroid glands, or bone? |
| cord-318853-mxyxwkhx | This is certainly an accurate synthesis of an extensive and highly complex literature but does it make any sense? |
| cord-318853-mxyxwkhx | What practical meaning does"immune control"have for the individual? |
| cord-318853-mxyxwkhx | Why should HCV replicating at 10 6- 7 geq/ ml at week 6 be invisible to the immune system but visible when replicating at 10 5 geq/ ml long term? |
| cord-271790-3s8o774l | , de que fizemos eco, é possível retirar consequências para o quotidiano na procura da prevenção da asma e da atopia? |
| cord-271790-3s8o774l | An association between genes and the environment Gene environment interaction in allergic disease: more questions, more answers? |
| cord-271790-3s8o774l | And the high risk of asthma in children who attend nursery schools, with the greatest amount of infections in the lower respiratory tract 69? |
| cord-271790-3s8o774l | And what about bacterial infections? |
| cord-271790-3s8o774l | Como sair desta encruzilhada? |
| cord-271790-3s8o774l | Endotoxin-stimulated innate immunity: a contributing factor for asthma Does environmental endotoxin exposure prevents asthma? |
| cord-271790-3s8o774l | Frequency of infections in the first years of life and risk of asthma, atopy and airway hyperresponsiveness among schoolage children Is the prevalence of wheeze in children altered by neonatal BCG vaccination? |
| cord-271790-3s8o774l | How would the parallel increase in auto- immune inflammatory diseases, Th 1, expression and asthma and allergy 71 or the fact that autoimmune diseases are higher in asthmatics 64 be explained on that basis? |
| cord-271790-3s8o774l | If we were, how would one explain the rise in the asthma rate seen in the poorer USA neighbourhoods 67? |
| cord-271790-3s8o774l | In 2003, Holtzman 75 unveiled a theory that could be true in some cases: the asthmatic risco de asma em crianças que frequentam infantários, com maior número de infecções do tracto respiratório inferior 69? |
| cord-271790-3s8o774l | In the midst of so much confusion, is it possible to reach any conclusions on asthma and allergy prevention which are applicable to the here and now? |
| cord-271790-3s8o774l | Is virus on its own the culprit or is it the last straw to break the back of a particularly fragile situation, possibly genetically caused? |
| cord-271790-3s8o774l | Mas, claro, isto não significa apoiar certos fundamentalismos already carried out into endotoxins, provide future guidance? |
| cord-271790-3s8o774l | Nesta lógica, como se explica o aumento de prevalência da asma nos bairros pobres dos Estados Unidos 67? |
| cord-271790-3s8o774l | Not all farming environments protect against the development of asthma and wheeze in children Hygiene hypothesis and endotoxin: what is the evidence? |
| cord-271790-3s8o774l | On roots of childhood asthma: the role of respiratory infections Probiotic for the prevention of treatment or allergic diseases Hay fever, hygiene and household size Primary and secondary prevention of allergic asthma Role of microbial burden in aetiology of allergy and asthma Hygiene hypothesis: fact or fiction? |
| cord-271790-3s8o774l | Or how in Africa and Latin America, in areas rife with bilharzia, which promotes Th 2 secretion and IgE synthesis, is the prevalence of that parasite in an inverse correlation with asthma and allergy 68? |
| cord-271790-3s8o774l | Or is it a mere marker? |
| cord-271790-3s8o774l | Ou será um mero marcador? |
| cord-271790-3s8o774l | Será que os estudos genéticos, como os feitos para as endotoxinas, nos poderão orientar futuramente? |
| cord-271790-3s8o774l | Será que temos de mudar os nossos padrões de vida? |
| cord-271790-3s8o774l | The increased prevalence of allergy and the hygiene hypothesis: missing immune deviation, reduced immune suppression, or both? |
| cord-271790-3s8o774l | The many faces of the hygiene hypothesis Asthmatic bronchial epithelial cells have a deficient innate response to infection with rhinovirus Respiratory viral infections and asthma pathogenesis: a critical role for dendritic cells? |
| cord-271790-3s8o774l | Unraveling the complexities Early-- life respiratory viral infections, atopic sensitization, and risk of subsequent development of persistent asthma A reformulation of the hygiene hypothesis: maternal infeccious diseases confer protection against asthma in the infant? |
| cord-271790-3s8o774l | What is the path out of this crossroads? |
| cord-271790-3s8o774l | Will we have to change the way we lead our lives? |
| cord-271790-3s8o774l | a gota que faz extravasar a água numa situação de particular fragilidade, eventualmente com causa genética? |
| cord-271790-3s8o774l | cells in the big picture of immunology A reformulation of the hygiene hypothesis: maternal infectious diseases confer protection against asthma in the infant? |
| cord-271790-3s8o774l | facto de as doen ças autoimunes terem elevada prevalência nos asmáticos 64? |
| cord-271790-3s8o774l | the virus, the disease and the immune response Is asthma an infectious disease? |
| cord-341029-49360l2a | : Inferences on protein evolution Are viruses a source of new protein folds for organisms? |
| cord-341029-49360l2a | Applying both comparative genomic and phylogenomic strategies, we asked a number of crucial questions: Can we quantify viral diversity? |
| cord-341029-49360l2a | Are viruses infecting different organisms evolutionarily related? |
| cord-341029-49360l2a | Are viruses monophyletic or polyphyletic? |
| cord-341029-49360l2a | Can we identify protein folds that define viral lineages based on common virion architectures? |
| cord-341029-49360l2a | Here, the more relevant question was asked: Do viruses infecting distantly related hosts share common protein folds? |
| cord-341029-49360l2a | How many unique protein folds exist in the virosphere? |
| cord-341029-49360l2a | The origins and ongoing evolution of viruses Viral proteins functioning in organelles: A cryptic origin? |
| cord-341029-49360l2a | What is the predominant direction of gene transfer( cell- to- virus or virus- to- cell)? |
| cord-341029-49360l2a | What were the earliest replicons? |
| cord-341029-49360l2a | Where do viruses lie on the tree of life? |
| cord-316063-9bg2dm8e | Even the Daily Mail- typically unwavering in its automatic support for the government- ask incredulously of the pair,'What Planet Are They On?'. |
| cord-316063-9bg2dm8e | Improvisation and the Theatre Endless War? |
| cord-316063-9bg2dm8e | Johnson's'unexpected mugger'comment, one viewer asks rhetorically,'it was n't really that unexpected though, was it?', another reacts that'we saw this coming over the hill from China, so I do n't think it was that much of a surprise'.' |
| cord-316063-9bg2dm8e | Legitimacy was high throughout this middle period of redress, partly because government Opinium and YouGov polling on public perception of the government's handling of the crisis actions appeared to be conforming to their projected definition of the situation, which itself coincided with dominant public answers to the question of'what is it that's going on here?'. |
| cord-316063-9bg2dm8e | Melancholia or convivial culture? |
| cord-316063-9bg2dm8e | Stubborn inductees have their own ways of answering the question of'what is it that's going on here?' |
| cord-316063-9bg2dm8e | The British Political Elite Coronavirus: Can herd immunity protect the population? |
| cord-316063-9bg2dm8e | The Guardian Coronavirus lockdown: What are the new rules announced by Boris Johnson? |
| cord-316063-9bg2dm8e | The Independent The hero beyond himself: Heroic death in ancient Greek poetry and art Panorama- Has the Government Failed the NHS? |
| cord-316063-9bg2dm8e | The Spectator Contagious: Cultures, Carriers, and the Outbreak Narrative Alert for what?' |
| cord-316063-9bg2dm8e | The ambiguities described above- in narrativizing what the real threat was( was it still the virus? |
| cord-316063-9bg2dm8e | The top scientific advisors were never asked to sign off on the slogan, and Prof. John Dury, who sits on the behavioural subcommittee of SAGE typically tasked with devising public communications during emergencies asked'Who is advising on the current messaging? |
| cord-316063-9bg2dm8e | These proclamations, however, were contradicted by the broadening out of the metaphors used to describe the antagonist( from'foreign invader'to'mugger'), the ambiguity as to what the primary threat in fact was( was it the virus, or the'cost to our way of life'incurred by controlling the spread of the virus?), and by the rolling back of the restrictions that had previously been in place. |
| cord-316063-9bg2dm8e | What Is an Epidemic? |
| cord-316063-9bg2dm8e | Why War?: |
| cord-316063-9bg2dm8e | Why do empty signifiers matter to politics? |
| cord-316063-9bg2dm8e | Wrong? |
| cord-316063-9bg2dm8e | was it now the effects of countering the virus?), at what level of gravity this threat should be understood, what powers of agency existed to fight the virus, and indeed what the new messaging condensed in the revised slogans |
| cord-350703-vrqltz3s | For example, for an anti- DENV drug, in what cells and tissues does the virus replicate during the acute phase of infection in humans? |
| cord-350703-vrqltz3s | He will also provide a look ahead: what research is needed, where do we go from here? |
| cord-350703-vrqltz3s | How can ISAR members make use of our social media sites? |
| cord-350703-vrqltz3s | How could we engineer compounds to be selectively loaded onto these sites? |
| cord-350703-vrqltz3s | What are the principal diseases for which antivirals are needed? |
| cord-350703-vrqltz3s | What aspects have you found most satisfying? |
| cord-350703-vrqltz3s | What has been your own experience? |
| cord-350703-vrqltz3s | What is your personal experience with social networking and science? |
| cord-350703-vrqltz3s | What new approaches are you using in your research? |
| cord-323311-xl2fv0qx | ( i) Is systems biology too complicated and too expensive to become the pre- eminent approach in virology and immunology? |
| cord-323311-xl2fv0qx | ( ii) Are mathematicians and computer scientists up to the challenges? |
| cord-323311-xl2fv0qx | ( ii) Do bat CoVs persist in bat populations and/or individual bats? |
| cord-323311-xl2fv0qx | ( ii) Is CCHFV able to enter and replicate into these cell lines? |
| cord-323311-xl2fv0qx | ( iii) Do bats control viral infection differently from other mammals? |
| cord-323311-xl2fv0qx | ( iv) How can new principal investigators best be identified and appointed? |
| cord-323311-xl2fv0qx | Amongst Small- Scale Dairy Farmers in Zimbabwe? |
| cord-323311-xl2fv0qx | Does CCHFV modulate the in vitro cellular response? |
| cord-323311-xl2fv0qx | How does functional response compare across the three species? |
| cord-323311-xl2fv0qx | How will new technologies like Next Generation Sequencing impact virus systems biology research, especially in the context of RNA sequencing? |
| cord-323311-xl2fv0qx | In response to the perennial question after any scientific experiment,''Where do we go from here?'' |
| cord-323311-xl2fv0qx | The research objectives were to consider:( i) how does CCHFV affect hepatocarcinoma cell lines? |
| cord-323311-xl2fv0qx | The underlying question which Professor Gray and his research team is tackling is: Which human, animal and environmental factors predict disease? |
| cord-323311-xl2fv0qx | What Confidence Do We Really Have? |
| cord-323311-xl2fv0qx | What are the potential interactions of infected bats with the human population? |
| cord-323311-xl2fv0qx | What are the top functions altered during infection? |
| cord-323311-xl2fv0qx | What did this 6th International Conference on Emerging Zoonoses achieve? |
| cord-323311-xl2fv0qx | What triggers the spillover of bat viruses into other animals? |
| cord-323311-xl2fv0qx | Why do bats seem to be able to co- exist with a great diversity of viruses without showing disease signs? |
| cord-323311-xl2fv0qx | Will the food safety modernization act help prevent Outbreaks of foodborne illness? |
| cord-323311-xl2fv0qx | how to translate breakthroughs into public health practice Development of an algorithm for assessing the risk to food safety posed by a new animal disease and Investigation Teams, and members of the Outbreak Control Integrative deep sequencing of the mouse lung transcriptome reveals differential expression of diverse classes of small RNAs in response to respiratory virus infection Differential activation profiles of Crimean- Congo hemorrhagic fever virus- and Dugbe virus- infected antigen- presenting cells Vaccinomics and personalized vaccinology: is science leading us toward a new path of directed vaccine development and discovery? |
| cord-323311-xl2fv0qx | to better understand influenza virus pathogenesis through a cross- species analysis that considered three crucial questions:( i) which genes change over the course of acute infection? |
| cord-323311-xl2fv0qx | what is the prevalence and diversity of bat CoVs in New World bats? |
| cord-257220-fe2sacjj | , CD25? |
| cord-257220-fe2sacjj | Are there any other porcine virus that infect macrophages and are eliminated in 7- 14 days? |
| cord-257220-fe2sacjj | Are those with a suppressor phenotype functionally suppressive? |
| cord-257220-fe2sacjj | CD25? |
| cord-257220-fe2sacjj | CD25? |
| cord-257220-fe2sacjj | CD25? |
| cord-257220-fe2sacjj | CD8? |
| cord-257220-fe2sacjj | CD8? |
| cord-257220-fe2sacjj | Comparative cellular studies of isolator piglets infected with PRRSV and SIV failed to reveal any evidence of immune suppression, i.e., lack of evidence for elevation of Fox3p CD4? |
| cord-257220-fe2sacjj | Could an abundance of selfreactive Th2 cells, some of which may crossreact with PRRSV, be sufficient to drive rapid differentiation to plasma cells or perhaps IL-6 from infected MQ? |
| cord-257220-fe2sacjj | Could it be the lack of functional Tregs that permits runaway B cell proliferation and differentiation? |
| cord-257220-fe2sacjj | Development of T cells in thymus is well described in textbooks, and at a certain stage, CD4? |
| cord-257220-fe2sacjj | Do neutralizing antibodies bind those viral epitopes that prevent their recognition by the receptors on potentially permissive cells or do they inhibit the fusion of the viral membrane with the endocytic membrane? |
| cord-257220-fe2sacjj | Do these IFNa- impaired macrophages preferentially or inappropriately stimulate certain T cell subsets or do they promote differentiation of MDSC? |
| cord-257220-fe2sacjj | Does it also cause more severe immune dysregulation? |
| cord-257220-fe2sacjj | Elevation of P3 expressing, CD4? |
| cord-257220-fe2sacjj | For example, does PRRSV infect lymphocytes or only macrophages/ dendritic cells? |
| cord-257220-fe2sacjj | Foxp3? |
| cord-257220-fe2sacjj | How easy is that? |
| cord-257220-fe2sacjj | However, is the effect of HP- PRRSV merely a quantitative difference or does it have a qualitative effect? |
| cord-257220-fe2sacjj | In isolator piglets, only the subset of CD2? |
| cord-257220-fe2sacjj | Is simple blocking by antibodies enough or is help needed from an immune complex? |
| cord-257220-fe2sacjj | Namely, does HP- PRRSV primarily target the thymus so its greatest impact is on T cell cells development? |
| cord-257220-fe2sacjj | Porcine reproductive and respiratory syndrome virus induces CD4? |
| cord-257220-fe2sacjj | ROS- dependent suppression of CD4? |
| cord-257220-fe2sacjj | Since PRRSV targets macrophages, could their infection result in differentiation of myeloid cells to MDSC? |
| cord-257220-fe2sacjj | So what is the purpose of PRRS research: to simulate the farm experience and produce a vaccine''in the blind''or to first understand how the virus affects the host? |
| cord-257220-fe2sacjj | Some have reported the presence of CD4? |
| cord-257220-fe2sacjj | The extraordinary hypergammaglobulinemia simultaneously occurs as B cells rapidly differentiate to plasma cells in a manner in which the intermediate stage of activated B cells( CD2? |
| cord-257220-fe2sacjj | The same applies to cytokines: what cells are making which cytokines and where are these cells histologically located since cytokines typically act at short distances? |
| cord-257220-fe2sacjj | This is a valid assay for the cell line and the PRRSV strain used but does it test whether neutralization has occurred in vivo in infected animals in which different target cells and virus variants are interacting? |
| cord-257220-fe2sacjj | We hypothesize that the suppression of innate immunity can be an important contributing factor to the modulation of host immune responses because type I IFNs promote antigen presentation and natural killer cell functions, enhance antibody production of B cells, and play an important role in the differentiation of both CD4? |
| cord-257220-fe2sacjj | and CD8? |
| cord-257220-fe2sacjj | and CD8? |
| cord-257220-fe2sacjj | cells with a suppressor phenotype( CD4? |
| cord-257220-fe2sacjj | interleukin-10 and regulatory T- lymphocytes( Treg) Induction of inducible CD4? |
| cord-257220-fe2sacjj | porcine reproductive and respiratory syndrome virus Age- dependent resistance to porcine reproductive and respiratory syndrome virus replication in swine Identification of immunodominant T cell epitopes present in glycoprotein 5 of the North American genotype of porcine reproductive and respiratory syndrome virus Cell- mediated immunity to porcine reproductive and respiratory syndrome virus in swine Evaluation of protective immunity in gilts inoculated with the NADC-8 isolate of porcine reproductive and respiratory syndrome virus( PRRSV) and challenged- exposed with an antigenically distinct isolate Control and elimination of porcine reproductive and respiratory syndrome virus Effect on total pigs weaned of herd closure for elimination of porcine reproductive and respiratory syndrome virus Functional impairment of PRRSV- specific peripheral CD3? |
| cord-333351-homxj9uz | Certains au moins des virus propagés par les chauves- souris frugivores sont- ils, à l'origine, des virus de végétaux? |
| cord-333351-homxj9uz | Ces passages sont- ils rares, accidentels? |
| cord-333351-homxj9uz | Dès lors, que faire? |
| cord-333351-homxj9uz | Est- ce en relation avec un fonctionnement particulier du système immunitaire? |
| cord-333351-homxj9uz | Existe- t- il des saisons ou des écosystèmes plus propices que d'autres? |
| cord-333351-homxj9uz | La détection des émergences est- elle simplement liée à une amélioration des activités de surveillance et de dépistage des virus, à l'action conjointe de plusieurs de ces facteurs? |
| cord-333351-homxj9uz | Les chauves- souris insectivores sont- elles, pour certains virus, de simples hôtes- relais entre les insectes et les mammifères? |
| cord-333351-homxj9uz | Pourquoi certaines régions semblent épargnées, par exemple par les virus Ebola? |
| cord-333351-homxj9uz | Pourquoi les infections par certains virus, comme Hendra, Menangle et d'autres, demeurent- elles rares et sporadiques, du moins jusqu'à présent, alors que d'autres virus donnent lieu à des épidémies/ épizooties massives? |
| cord-333351-homxj9uz | Quelles sont les raisons de cette tolérance? |
| cord-333351-homxj9uz | Sont- ils liés à un contact écologique fortuit, à des bouleversements écologiques liés aux activités humaines, à un changement du climat? |
| cord-333351-homxj9uz | Sur ce point, la fréquence des infections persistantes à virus à ARN pourrait traduire un fonctionnement particulier des mécanismes immunitaires( immunité innée?) |
| cord-333351-homxj9uz | The distribution of henipaviruses in Southeast Asia and Australasia: is Wallace's line a barrier to Nipah virus? |
| cord-333351-homxj9uz | animal n'a- t- il pas eu lieu plus tôt? |
| cord-333351-homxj9uz | délimiter les zones à risque d'émergence? |
| cord-333351-homxj9uz | en rapport avec ces millions d'années de coexistence des Chiroptères et des virus? |
| cord-333351-homxj9uz | les Chiroptères? |
| cord-333351-homxj9uz | qui, chez les autres mammifères, permettent l'élimination de ces virus? |
| cord-333351-homxj9uz | virales infectieuses? |
| cord-264884-ydkigome | ,, 2005? |
| cord-264884-ydkigome | A subset of human immunodefi ciency virus type 1 long- term nonprogressors is characterized by the unique presence of ancestral sequences in the viral population Does common architecture reveal a viral lineage spanning all three domains of life? |
| cord-264884-ydkigome | Accordingly, when contemplating the amazing complexity of the P1 immunity and how it evolved, Yarmolinsky posed the question;"Could the byzantine complexity of the controls at ImmI be the outcome, not of successive host- parasite accommodations, but of competition among related phages?" |
| cord-264884-ydkigome | Also, how do we defi ne information content or integrity of a consortia? |
| cord-264884-ydkigome | Can cooperation( or consortia behavior) result from any of these models? |
| cord-264884-ydkigome | Can this be considered an example of symbiosis in the accepted sense? |
| cord-264884-ydkigome | Could the adaptation to a host- specifi c persistence- based basal life strategy provide some explanations for the evolution of the higher fi delity RNA replicase of these coronaviruses? |
| cord-264884-ydkigome | DNA Viral eukaryogenesis: was the ancestor of the nucleus a complex DNA virus? |
| cord-264884-ydkigome | Did the need and selection for a larger genome override the use of error to generate adaptability as seen in poliovirus and HIV-1? |
| cord-264884-ydkigome | Does such a distributed pattern of evolution and gene novelty also apply to the phycodnaviruses? |
| cord-264884-ydkigome | Here a virus, there a virus, everywhere the same virus? |
| cord-264884-ydkigome | How can genetic complexity be created in such a circumstance? |
| cord-264884-ydkigome | How do we defi ne such fi tness since the mixture clearly matters? |
| cord-264884-ydkigome | How does MHV attain such stable and prevalent persistence in natural population yet retain the ability to cause disease in naive populations? |
| cord-264884-ydkigome | How generally important is this poliovirus in vivo quasispecies result? |
| cord-264884-ydkigome | How important are viruses in general to evolutionary biology? |
| cord-264884-ydkigome | How is information stability and higher fi tness attained with such errors? |
| cord-264884-ydkigome | How might such selection operate in natural populations? |
| cord-264884-ydkigome | How might we explain the increased fi delity and genome size of the nidoviruses? |
| cord-264884-ydkigome | How then do we link poxvirus evolution to other more ancient DNA viruses, such as PBCV-1 which has the same DNA replication mechanism, but distinct replication proteins? |
| cord-264884-ydkigome | If so, what selective pressures might have changed this seemingly basic feature? |
| cord-264884-ydkigome | If so, why is it that in sheep a distinctly different lineage of retrovirus( enJSRV) was also selected to provide a related placental function to a another mammal with signifi cantly different placental reproductive biology? |
| cord-264884-ydkigome | If we can accept the above conclusion concerning the role for viruses in the evolution of prokaryotes, we must then ask why such a successful evolutionary strategy was not apparently maintained in eukaryotes? |
| cord-264884-ydkigome | Is there any evidence that this result with poliovirus indeed represents a general virus- host evolutionary relationship in natural settings? |
| cord-264884-ydkigome | Protein repertoire of double- stranded DNA bacteriophages Characterization of the primary immunity region of the Escherichia coli linear plasmid prophage N15 Parvovirus variation for disease: a difference with RNA viruses? |
| cord-264884-ydkigome | Was there some change in viral adaptation in which quasispecies and generation of mixtures was no longer as important for adaptation? |
| cord-264884-ydkigome | Was this ERVL colonization of relevance to the ancient co- speciation of simian foamy virus and their primate host( Switzer et al., 2005)? |
| cord-264884-ydkigome | What could be more fascinating than a green sea slug- an animal that can use light for photosynthesis? |
| cord-264884-ydkigome | What do we know about the natural biology of these viruses, which might provide some insight into this? |
| cord-264884-ydkigome | What does structure tell us about virus evolution? |
| cord-264884-ydkigome | What exactly was the relevance of HERV endogenization to human survival and adaptations? |
| cord-264884-ydkigome | What is the fi tness consequence to the colony harboring MHV relative to its uninfected neighbor? |
| cord-264884-ydkigome | What maintains the MHV fi tness of natural persistence? |
| cord-264884-ydkigome | What then is the evolutionary relationship that links all of these seemingly distinct viruses? |
| cord-264884-ydkigome | What then is the fi tness and evolutionary consequence to E. coli harboring P1? |
| cord-264884-ydkigome | What was the role for SIV in the evolution of primate MHC( Vogel et al., 1999)? |
| cord-264884-ydkigome | Why is this relationship stable? |
| cord-264884-ydkigome | Why should prokaryotes and eukaryotes differ is such a fundamental way? |
| cord-264884-ydkigome | Why? |
| cord-264884-ydkigome | Why? |
| cord-264884-ydkigome | human and chimpanzee MHC I( Watkins, 1995; Kulski et al., 1999)? |
| cord-264884-ydkigome | tailed DNA bacteriophages Do viruses form lineages across different domains of life? |
| cord-340489-yo3cp5vs | Auf Befragen gibt er an Welche Frage ist zunächst zu stellen? |
| cord-340489-yo3cp5vs | Ist die Candidapneumonie eine häufige Erkrankung? |
| cord-340489-yo3cp5vs | Sie zunächst? |
| cord-340489-yo3cp5vs | Sprosspilzinfektionen endogen oder exogen erworben? |
| cord-340489-yo3cp5vs | Untersuchung veranlasst? |
| cord-340489-yo3cp5vs | Was empfehlen Sie dem Patienten? |
| cord-340489-yo3cp5vs | Welche sind die 3 wichtigsten Antimykotika- Substanzklassen? |
| cord-340489-yo3cp5vs | Welche therapeutischen Maßnahmen sind angezeigt? |
| cord-340489-yo3cp5vs | Werden Fadenpilzinfektionen endogen oder exogen erworben? |
| cord-340489-yo3cp5vs | Wie lautet Ihre Verdachtsdiagnose? |
| cord-340489-yo3cp5vs | Wie soll man HIV- infizierte Schwangere behandeln? |
| cord-340489-yo3cp5vs | Wie wird der Patient initial behandelt? |
| cord-340489-yo3cp5vs | Windpockenerkrankungen oder eine Gingivostomatitis herpetica behandelt werden? |
| cord-340489-yo3cp5vs | b. Welche Untersuchungen werden durchgeführt? |
| cord-340489-yo3cp5vs | c. Wie wird der Patient behandelt? |
| cord-340489-yo3cp5vs | d. Was wird dem Patienten gesagt? |
| cord-340489-yo3cp5vs | einer antiretroviralen Therapie bei HIV- Infektion? |
| cord-340489-yo3cp5vs | oder häufig gegen Fluconazol resistent? |
| cord-340489-yo3cp5vs | unteren Atemwege mit Candida species? |
| cord-340489-yo3cp5vs | unterschieden? |
| cord-340489-yo3cp5vs | werden? |
| cord-340489-yo3cp5vs | werden? |
| cord-353609-no3mbg5d | A virus reveals population structure and recent demographic history of its carnivore host Parasites: Proxies for host genealogy and ecology? |
| cord-353609-no3mbg5d | And how might co- infections with these undiscovered viruses influence the dynamics of the more well known viruses? |
| cord-353609-no3mbg5d | And what are the relative roles of genetic relatedness and contact rate for transmission? |
| cord-353609-no3mbg5d | And what are the relative roles of genetic relatedness and contact rate for transmission? |
| cord-353609-no3mbg5d | Are we in the midst of the sixth mass extinction? |
| cord-353609-no3mbg5d | As such, wild populations of rodents can be valuable as model disease systems to address relevant questions like: Are there key hosts for transmission? |
| cord-353609-no3mbg5d | As technology becomes more affordable, and thus accessible, there will be increasing opportunities to ask large- scale questions such as: How does the virosphere vary across space and time? |
| cord-353609-no3mbg5d | Can we use this to define risk of cross- species transmission or to inform conservation efforts? |
| cord-353609-no3mbg5d | Could parasites destabilize mouse populations? |
| cord-353609-no3mbg5d | For instance, what characteristics of hosts and viruses make them more or less likely to be involved in cross- species transmission? |
| cord-353609-no3mbg5d | How do these pathogens flow through populations? |
| cord-353609-no3mbg5d | How does it vary across species? |
| cord-353609-no3mbg5d | How does prevalence vary seasonally or over time? |
| cord-353609-no3mbg5d | How many species? |
| cord-353609-no3mbg5d | Pending questions include: Which geographic areas will experience more disease and conservation problems? |
| cord-353609-no3mbg5d | The peopling of the Pacific from a bacterial perspective Distinguishing human ethnic groups by means of sequences from Heliclobacter pylori: Lessons from Ladakh A parasite reveals cryptic phylogeographic history of its host Are lice good proxies for host history? |
| cord-353609-no3mbg5d | What characteristics of hosts and viruses make them more or less likely to be involved in cross- species transmission events? |
| cord-353609-no3mbg5d | What is the contact rate between the reservoir and humans? |
| cord-353609-no3mbg5d | Which areas pose the highest risk for pandemic spread of pathogens? |